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Conserved domains on  [gi|47458043|ref|NP_998819|]
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armadillo repeat-containing protein 8 isoform 1 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
35-198 1.08e-05

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 47.19  E-value: 1.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458043  35 GNNKQKANLIVLGAVPRLLYLLQQEtsSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKF-IEACLr 113
Cdd:COG5064 273 GPNEKIQAVLDVGIPGRLVELLSHE--SAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIrKEACW- 349

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458043 114 clrTI--FTSPVTPEELLYTDATVIPHLMALLSRSRY-TQEYIC----QIFSHCCKGPDHQTILFNHGAVQNIAHLLTSL 186
Cdd:COG5064 350 ---TIsnITAGNTEQIQAVIDANLIPPLIHLLSSAEYkIKKEACwaisNATSGGLNRPDIIRYLVSQGFIKPLCDLLDVV 426

                       170
                ....*....|..
gi 47458043 187 SYKVRMQALKCF 198
Cdd:COG5064 427 DNKIIEVALDAI 438
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
35-198 1.08e-05

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 47.19  E-value: 1.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458043  35 GNNKQKANLIVLGAVPRLLYLLQQEtsSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKF-IEACLr 113
Cdd:COG5064 273 GPNEKIQAVLDVGIPGRLVELLSHE--SAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIrKEACW- 349

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458043 114 clrTI--FTSPVTPEELLYTDATVIPHLMALLSRSRY-TQEYIC----QIFSHCCKGPDHQTILFNHGAVQNIAHLLTSL 186
Cdd:COG5064 350 ---TIsnITAGNTEQIQAVIDANLIPPLIHLLSSAEYkIKKEACwaisNATSGGLNRPDIIRYLVSQGFIKPLCDLLDVV 426

                       170
                ....*....|..
gi 47458043 187 SYKVRMQALKCF 198
Cdd:COG5064 427 DNKIIEVALDAI 438
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
35-198 1.08e-05

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 47.19  E-value: 1.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458043  35 GNNKQKANLIVLGAVPRLLYLLQQEtsSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKF-IEACLr 113
Cdd:COG5064 273 GPNEKIQAVLDVGIPGRLVELLSHE--SAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIrKEACW- 349

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458043 114 clrTI--FTSPVTPEELLYTDATVIPHLMALLSRSRY-TQEYIC----QIFSHCCKGPDHQTILFNHGAVQNIAHLLTSL 186
Cdd:COG5064 350 ---TIsnITAGNTEQIQAVIDANLIPPLIHLLSSAEYkIKKEACwaisNATSGGLNRPDIIRYLVSQGFIKPLCDLLDVV 426

                       170
                ....*....|..
gi 47458043 187 SYKVRMQALKCF 198
Cdd:COG5064 427 DNKIIEVALDAI 438
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
14-320 6.19e-05

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 44.88  E-value: 6.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458043  14 LFDPDPQKVLQGVIDMKNAV-IGNNKQKANLIVLGAVPRLLYLLQqETSSTELKTECAVVLGSLAMGTENNVKSLLDCHI 92
Cdd:COG5064  80 LFSDDIEQQLQAVYKFRKLLsKETSPPIQPVIDAGVVPRFVEFMD-EIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGA 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458043  93 IPALLQGLLSPDLKFIEACLRCLRTIF-TSPVTPEELLYTDAtvIPHLMALLSRSRYTQEYI---CQIFSHCCKG----P 164
Cdd:COG5064 159 VPLFIQLLSSTEDDVREQAVWALGNIAgDSEGCRDYVLQCGA--LEPLLGLLLSSAIHISMLrnaTWTLSNLCRGknppP 236

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458043 165 DHQTIlfnHGAVQNIAHLLTSLSYKVRMQALKCFSVLAfenpQVSMTLVNVLVDGELLPQIfVKMLQRDkpiemqltSAK 244
Cdd:COG5064 237 DWSNI---SQALPILAKLIYSRDPEVLVDACWAISYLS----DGPNEKIQAVLDVGIPGRL-VELLSHE--------SAK 300

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458043 245 CLTYMCRA-GAIRTDD--------NCIVLKTLPCLVRMcSKERLleeRVEGAETLAYLIEPDVElQRIASITDHLIAMLA 315
Cdd:COG5064 301 IQTPALRSvGNIVTGSddqtqviiNCGALKAFRSLLSS-PKENI---RKEACWTISNITAGNTE-QIQAVIDANLIPPLI 375


                ....*
gi 47458043 316 DYFKY 320
Cdd:COG5064 376 HLLSS 380
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
8-111 2.04e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 40.26  E-value: 2.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47458043   8 RHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLqqETSSTELKTECAVVLGSLAMGTENNVKSL 87
Cdd:COG5064 288 GRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLL--SSPKENIRKEACWTISNITAGNTEQIQAV 365

                        90       100
                ....*....|....*....|....*
gi 47458043  88 LDCHIIPALLQGLLSPDLKF-IEAC 111
Cdd:COG5064 366 IDANLIPPLIHLLSSAEYKIkKEAC 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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