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Conserved domains on  [gi|114687015|ref|XP_001140006|]
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dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform X1 [Pan troglodytes]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 19-354 1.54e-27

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam03901:

Pssm-ID: 473917  Cd Length: 414  Bit Score: 114.00  E-value: 1.54e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114687015   19 AVATVHLVICPYT---KVEESFNLQATHDLLYHWQDLEQYDHLEFPGVVPRTFLgpvviAVFSSPAVYVLSLLEMSKFYS 95
Cdd:pfam03901   5 LLLALRLLLALLVqtsDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYP-----LLFALPYYLLARLFGDSKYLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114687015   96 QLIVRGVLGLGVIFGLWTLQKEVRRHFGAMVATMFCWVTAMQFHLMFYCTRTLPNVLALPVVLLALTAWLRH---EWARF 172
Cdd:pfam03901  80 FYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYgntSVSNY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114687015  173 IWLSAFAIIVF-----RAELCLFLGLLLLLALGN-RKVSVVRTLHHAIPAGILCLGLT----VAVDSYFWRQLTWPEGKV 242
Cdd:pfam03901 160 KYLKAVLLIAAlailgRPTSALLWLPLVLYLLLRlRGKRLKLFLFLAISLGLLVALLVlgavILIDSYFYGRFVFTPLNF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114687015  243 LWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGLV------DRRTHALTVLALGFVALYSLLPHKELRFIIYA 316
Cdd:pfam03901 240 LKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLvlllrkVSRLSQLLAPILIWLFIYSLQPHKEERFLYPV 319

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 114687015  317 FPMLNITAARGCS-YLLNNYKKSWLYKAGSLLVIGHLVV 354
Cdd:pfam03901 320 YPLILLSAAIALTrLSRRSWKVRKKLSLLFLLLFFNVSL 358
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 19-354 1.54e-27

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 114.00  E-value: 1.54e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114687015   19 AVATVHLVICPYT---KVEESFNLQATHDLLYHWQDLEQYDHLEFPGVVPRTFLgpvviAVFSSPAVYVLSLLEMSKFYS 95
Cdd:pfam03901   5 LLLALRLLLALLVqtsDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYP-----LLFALPYYLLARLFGDSKYLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114687015   96 QLIVRGVLGLGVIFGLWTLQKEVRRHFGAMVATMFCWVTAMQFHLMFYCTRTLPNVLALPVVLLALTAWLRH---EWARF 172
Cdd:pfam03901  80 FYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYgntSVSNY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114687015  173 IWLSAFAIIVF-----RAELCLFLGLLLLLALGN-RKVSVVRTLHHAIPAGILCLGLT----VAVDSYFWRQLTWPEGKV 242
Cdd:pfam03901 160 KYLKAVLLIAAlailgRPTSALLWLPLVLYLLLRlRGKRLKLFLFLAISLGLLVALLVlgavILIDSYFYGRFVFTPLNF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114687015  243 LWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGLV------DRRTHALTVLALGFVALYSLLPHKELRFIIYA 316
Cdd:pfam03901 240 LKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLvlllrkVSRLSQLLAPILIWLFIYSLQPHKEERFLYPV 319

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 114687015  317 FPMLNITAARGCS-YLLNNYKKSWLYKAGSLLVIGHLVV 354
Cdd:pfam03901 320 YPLILLSAAIALTrLSRRSWKVRKKLSLLFLLLFFNVSL 358
PLN02816 PLN02816
mannosyltransferase
 214-319 1.57e-06

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 50.42  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114687015 214 IPAGILCLGLTVAVDSYFWRQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGLVDRRTHALTV 293
Cdd:PLN02816 244 IPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKSKNQKLSA 323

                         90       100
                 ....*....|....*....|....*.
gi 114687015 294 LALGFVALYSLLPHKELRFIIYAFPM 319
Cdd:PLN02816 324 LILWVLAIYSILGHKEFRFVLPVLPI 349
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 19-354 1.54e-27

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 114.00  E-value: 1.54e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114687015   19 AVATVHLVICPYT---KVEESFNLQATHDLLYHWQDLEQYDHLEFPGVVPRTFLgpvviAVFSSPAVYVLSLLEMSKFYS 95
Cdd:pfam03901   5 LLLALRLLLALLVqtsDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYP-----LLFALPYYLLARLFGDSKYLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114687015   96 QLIVRGVLGLGVIFGLWTLQKEVRRHFGAMVATMFCWVTAMQFHLMFYCTRTLPNVLALPVVLLALTAWLRH---EWARF 172
Cdd:pfam03901  80 FYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYgntSVSNY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114687015  173 IWLSAFAIIVF-----RAELCLFLGLLLLLALGN-RKVSVVRTLHHAIPAGILCLGLT----VAVDSYFWRQLTWPEGKV 242
Cdd:pfam03901 160 KYLKAVLLIAAlailgRPTSALLWLPLVLYLLLRlRGKRLKLFLFLAISLGLLVALLVlgavILIDSYFYGRFVFTPLNF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114687015  243 LWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGLV------DRRTHALTVLALGFVALYSLLPHKELRFIIYA 316
Cdd:pfam03901 240 LKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLvlllrkVSRLSQLLAPILIWLFIYSLQPHKEERFLYPV 319

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 114687015  317 FPMLNITAARGCS-YLLNNYKKSWLYKAGSLLVIGHLVV 354
Cdd:pfam03901 320 YPLILLSAAIALTrLSRRSWKVRKKLSLLFLLLFFNVSL 358
PLN02816 PLN02816
mannosyltransferase
 214-319 1.57e-06

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 50.42  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114687015 214 IPAGILCLGLTVAVDSYFWRQLTWPEGKVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGLVDRRTHALTV 293
Cdd:PLN02816 244 IPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKSKNQKLSA 323

                         90       100
                 ....*....|....*....|....*.
gi 114687015 294 LALGFVALYSLLPHKELRFIIYAFPM 319
Cdd:PLN02816 324 LILWVLAIYSILGHKEFRFVLPVLPI 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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