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Conserved domains on  [gi|124513944|ref|XP_001350328|]
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cytochrome c oxidase subunit 2, putative [Plasmodium falciparum 3D7]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COX2 super family cl33359
cytochrome c oxidase subunit II; Provisional
 172-216 3.23e-12

cytochrome c oxidase subunit II; Provisional


The actual alignment was detected with superfamily member MTH00154:

Pssm-ID: 214438 [Multi-domain]  Cd Length: 227  Bit Score: 63.69  E-value: 3.23e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 124513944 172 FFW--IPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:MTH00154  63 IIWtiLPAIILIFIALPSLRLLYLLDEVNNPSITLKTIGHQWYWSYE 109
DsbD super family cl21514
Cytochrome C biogenesis protein transmembrane region; This family consists of the ...
 59-101 8.29e-03

Cytochrome C biogenesis protein transmembrane region; This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange proteins. These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family.


The actual alignment was detected with superfamily member PRK10019:

Pssm-ID: 473893  Cd Length: 279  Bit Score: 36.69  E-value: 8.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 124513944  59 NNAHTKNNHEHEsHTKGFYHHIDHHHGDPRAHLNEDGTRKPEY 101
Cdd:PRK10019 113 ERNWLENMHHHD-HDHDHDHDHEHHHDHGHHHHHEHGATAEEY 154
 
Name Accession Description Interval E-value
COX2 MTH00154
cytochrome c oxidase subunit II; Provisional
 172-216 3.23e-12

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214438 [Multi-domain]  Cd Length: 227  Bit Score: 63.69  E-value: 3.23e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 124513944 172 FFW--IPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:MTH00154  63 IIWtiLPAIILIFIALPSLRLLYLLDEVNNPSITLKTIGHQWYWSYE 109
CyoA COG1622
Heme/copper-type cytochrome/quinol oxidase, subunit 2 [Energy production and conversion];
166-216 9.33e-09

Heme/copper-type cytochrome/quinol oxidase, subunit 2 [Energy production and conversion];


Pssm-ID: 441229 [Multi-domain]  Cd Length: 229  Bit Score: 53.68  E-value: 9.33e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 124513944 166 LKVEFLFFWIPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:COG1622   77 TKLEIVWTVIPIIIVIVLAVPTLRVLHALDDAPEDPLTVEVTGYQWKWLFR 127
CcO_II_C cd13912
C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal ...
 202-216 3.36e-04

C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit II contains a copper-copper binuclear site called CuA, which is believed to be involved in electron transfer from cytochrome c to the binuclear center (active site) in subunit I.


Pssm-ID: 259979 [Multi-domain]  Cd Length: 130  Bit Score: 39.48  E-value: 3.36e-04
                         10
                 ....*....|....*
gi 124513944 202 MTVKVIGRQWYWIYE 216
Cdd:cd13912    3 LTIKAIGHQWYWSYE 17
COX2 pfam00116
Cytochrome C oxidase subunit II, periplasmic domain;
202-225 1.20e-03

Cytochrome C oxidase subunit II, periplasmic domain;


Pssm-ID: 395066 [Multi-domain]  Cd Length: 120  Bit Score: 37.77  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|....
gi 124513944  202 MTVKVIGRQWYWIYEVespPDDDD 225
Cdd:pfam00116   1 LTIKAIGHQWYWSYEY---TDFGD 21
PRK10019 PRK10019
nickel/cobalt efflux transporter RcnA;
59-101 8.29e-03

nickel/cobalt efflux transporter RcnA;


Pssm-ID: 236641  Cd Length: 279  Bit Score: 36.69  E-value: 8.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 124513944  59 NNAHTKNNHEHEsHTKGFYHHIDHHHGDPRAHLNEDGTRKPEY 101
Cdd:PRK10019 113 ERNWLENMHHHD-HDHDHDHDHEHHHDHGHHHHHEHGATAEEY 154
 
Name Accession Description Interval E-value
COX2 MTH00154
cytochrome c oxidase subunit II; Provisional
 172-216 3.23e-12

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214438 [Multi-domain]  Cd Length: 227  Bit Score: 63.69  E-value: 3.23e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 124513944 172 FFW--IPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:MTH00154  63 IIWtiLPAIILIFIALPSLRLLYLLDEVNNPSITLKTIGHQWYWSYE 109
COX2 MTH00168
cytochrome c oxidase subunit II; Provisional
 168-216 5.99e-12

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177223 [Multi-domain]  Cd Length: 225  Bit Score: 62.69  E-value: 5.99e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124513944 168 VEFLFFWIPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:MTH00168  61 IEFVWTIIPAFILISLALPSLRLLYLMDEIDKPDLTIKAVGHQWYWSYE 109
COX2 MTH00139
cytochrome c oxidase subunit II; Provisional
 168-216 1.30e-11

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214429 [Multi-domain]  Cd Length: 226  Bit Score: 62.04  E-value: 1.30e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124513944 168 VEFLFFWIPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:MTH00139  61 VETIWTVLPAFILLFLALPSLRLLYLMDEVSDPYLTFKAVGHQWYWSYE 109
COX2 MTH00098
cytochrome c oxidase subunit II; Validated
 168-216 5.25e-11

cytochrome c oxidase subunit II; Validated


Pssm-ID: 177160 [Multi-domain]  Cd Length: 227  Bit Score: 60.12  E-value: 5.25e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124513944 168 VEFLFFWIPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:MTH00098  61 VETIWTILPAIILILIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYE 109
COX2 MTH00051
cytochrome c oxidase subunit II; Provisional
 168-217 1.36e-10

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177126 [Multi-domain]  Cd Length: 234  Bit Score: 59.02  E-value: 1.36e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 124513944 168 VEFLFFWIPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYEV 217
Cdd:MTH00051  63 IEIIWTLIPAAILIFIAFPSLKLLYLMDEVIDPALTIKAIGHQWYWSYEY 112
COX2 MTH00023
cytochrome c oxidase subunit II; Validated
 168-216 1.64e-10

cytochrome c oxidase subunit II; Validated


Pssm-ID: 214402 [Multi-domain]  Cd Length: 240  Bit Score: 58.99  E-value: 1.64e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124513944 168 VEFLFFWIPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:MTH00023  70 LEIVWTIIPAVILVFIALPSLKLLYLMDEVVSPALTIKAIGHQWYWSYE 118
COX2 MTH00117
cytochrome c oxidase subunit II; Provisional
 168-216 2.90e-10

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177178 [Multi-domain]  Cd Length: 227  Bit Score: 58.00  E-value: 2.90e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124513944 168 VEFLFFWIPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:MTH00117  61 VELIWTILPAIVLILLALPSLRILYLMDEINNPHLTIKAIGHQWYWSYE 109
COX2 MTH00140
cytochrome c oxidase subunit II; Provisional
 172-219 3.53e-10

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214430 [Multi-domain]  Cd Length: 228  Bit Score: 58.03  E-value: 3.53e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 124513944 172 FFW--IPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYEVES 219
Cdd:MTH00140  63 TIWtiVPALILVFLALPSLRLLYLLDETNNPLLTVKAIGHQWYWSYEYSD 112
COX2 MTH00076
cytochrome c oxidase subunit II; Provisional
 167-216 6.18e-10

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 164646 [Multi-domain]  Cd Length: 228  Bit Score: 57.10  E-value: 6.18e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 124513944 167 KVEFLFFWIPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:MTH00076  60 EIEMVWTIMPAIILIVIALPSLRILYLMDEINDPHLTVKAIGHQWYWSYE 109
COX2 MTH00008
cytochrome c oxidase subunit II; Validated
 167-216 1.02e-09

cytochrome c oxidase subunit II; Validated


Pssm-ID: 164584 [Multi-domain]  Cd Length: 228  Bit Score: 56.40  E-value: 1.02e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 124513944 167 KVEFLFFWIPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:MTH00008  60 QIETIWTILPALILLFLAFPSLRLLYLMDEVSNPSITLKTIGHQWYWSYE 109
COX2 MTH00038
cytochrome c oxidase subunit II; Provisional
 175-216 1.78e-09

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177113 [Multi-domain]  Cd Length: 229  Bit Score: 55.86  E-value: 1.78e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 124513944 175 IPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:MTH00038  68 VPAFILIFIALPSLQLLYLMDEVNNPFLTIKAIGHQWYWSYE 109
COX2 MTH00185
cytochrome c oxidase subunit II; Provisional
 167-216 6.60e-09

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 164736 [Multi-domain]  Cd Length: 230  Bit Score: 54.12  E-value: 6.60e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 124513944 167 KVEFLFFWIPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:MTH00185  60 EIEIVWTILPAIILIMIALPSLRILYLMDEINDPHLTIKAMGHQWYWSYE 109
CyoA COG1622
Heme/copper-type cytochrome/quinol oxidase, subunit 2 [Energy production and conversion];
166-216 9.33e-09

Heme/copper-type cytochrome/quinol oxidase, subunit 2 [Energy production and conversion];


Pssm-ID: 441229 [Multi-domain]  Cd Length: 229  Bit Score: 53.68  E-value: 9.33e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 124513944 166 LKVEFLFFWIPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:COG1622   77 TKLEIVWTVIPIIIVIVLAVPTLRVLHALDDAPEDPLTVEVTGYQWKWLFR 127
COX2 MTH00129
cytochrome c oxidase subunit II; Provisional
 168-216 1.90e-08

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177187 [Multi-domain]  Cd Length: 230  Bit Score: 52.79  E-value: 1.90e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124513944 168 VEFLFFWIPTLIIFSIAIPCFTMLYMLDEIVHTTMTVKVIGRQWYWIYE 216
Cdd:MTH00129  61 IEIIWTVLPAVILILIALPSLRILYLMDEINDPHLTIKAMGHQWYWSYE 109
COX2 MTH00027
cytochrome c oxidase subunit II; Provisional
 168-218 1.60e-06

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214405 [Multi-domain]  Cd Length: 262  Bit Score: 47.71  E-value: 1.60e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 124513944 168 VEFLFFWIPTLIIFSIAIPCFTMLYMLDEIVHTT-MTVKVIGRQWYWIYEVE 218
Cdd:MTH00027  92 IEVIWTLIPAFILILIAFPSLRLLYIMDECGFSAnITIKVTGHQWYWSYSYE 143
COX2 MTH00047
cytochrome c oxidase subunit II; Provisional
 168-219 1.22e-05

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214412 [Multi-domain]  Cd Length: 194  Bit Score: 44.56  E-value: 1.22e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 124513944 168 VEFLFFWIPTLIIFsiaIPCFTMLYML--DEIVHTTMTVKVIGRQWYWIYEVES 219
Cdd:MTH00047  49 LELLWTVVPTLLVL---VLCFLNLNFItsDLDCFSSETIKVIGHQWYWSYEYSF 99
COX2 MTH00080
cytochrome c oxidase subunit II; Provisional
 169-216 4.29e-05

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177149 [Multi-domain]  Cd Length: 231  Bit Score: 43.07  E-value: 4.29e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 124513944 169 EFLFFWIPTLIIFSIAIPCFTMLYMLDEI-VHTTMTVKVIGRQWYWIYE 216
Cdd:MTH00080  64 ELLCSVFPVLILLMQMVPSLSLLYYYGLMnLDSNLTVKVTGHQWYWSYE 112
CcO_II_C cd13912
C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal ...
 202-216 3.36e-04

C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit II contains a copper-copper binuclear site called CuA, which is believed to be involved in electron transfer from cytochrome c to the binuclear center (active site) in subunit I.


Pssm-ID: 259979 [Multi-domain]  Cd Length: 130  Bit Score: 39.48  E-value: 3.36e-04
                         10
                 ....*....|....*
gi 124513944 202 MTVKVIGRQWYWIYE 216
Cdd:cd13912    3 LTIKAIGHQWYWSYE 17
COX2 pfam00116
Cytochrome C oxidase subunit II, periplasmic domain;
202-225 1.20e-03

Cytochrome C oxidase subunit II, periplasmic domain;


Pssm-ID: 395066 [Multi-domain]  Cd Length: 120  Bit Score: 37.77  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|....
gi 124513944  202 MTVKVIGRQWYWIYEVespPDDDD 225
Cdd:pfam00116   1 LTIKAIGHQWYWSYEY---TDFGD 21
PRK10019 PRK10019
nickel/cobalt efflux transporter RcnA;
59-101 8.29e-03

nickel/cobalt efflux transporter RcnA;


Pssm-ID: 236641  Cd Length: 279  Bit Score: 36.69  E-value: 8.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 124513944  59 NNAHTKNNHEHEsHTKGFYHHIDHHHGDPRAHLNEDGTRKPEY 101
Cdd:PRK10019 113 ERNWLENMHHHD-HDHDHDHDHEHHHDHGHHHHHEHGATAEEY 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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