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Conserved domains on  [gi|124805371|ref|XP_001350421|]
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Plasmodium exported protein (PHISTa-like), unknown function [Plasmodium falciparum 3D7]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRESAN super family cl23884
Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium ...
 149-207 1.30e-05

Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localize to membranes.


The actual alignment was detected with superfamily member TIGR01639:

Pssm-ID: 451595  Cd Length: 61  Bit Score: 41.47  E-value: 1.30e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 124805371  149 KYYDTLEQWNEEKIQNKLDKLDDIHSKLDKLIIWAQIQGSERLKTYSMVYTLRRLFKSL 207
Cdd:TIGR01639   2 KYNDLSKKLTKEELNEMINSLDEIPNRNDMLIIWNQVHGIERDKFVKMQENLKEYIQKL 60
PTZ00131 super family cl33167
glycophorin-binding protein; Provisional
 10-89 1.32e-04

glycophorin-binding protein; Provisional


The actual alignment was detected with superfamily member PTZ00131:

Pssm-ID: 185467 [Multi-domain]  Cd Length: 413  Bit Score: 42.06  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805371  10 ISNSARLNNKSVNSKNCTIYSFEqdEENRRNLSSRLLSTMHSS--ITILGVIFILILNVCLTKESSSSLIQINFNNSRKL 87
Cdd:PTZ00131   9 IKSAGDSNCKNFNSKNSSKYSLM--DVQEKNEKKNSLGAFHSKkiILIFGIIYVALLNAYICGDKYEKAADYGFREGRIL 86


                 ..
gi 124805371  88 AD 89
Cdd:PTZ00131  87 AE 88
 
Name Accession Description Interval E-value
P_fal_TIGR01639 TIGR01639
Plasmodium falciparum uncharacterized domain TIGR01639; This model represents a conserved ...
 149-207 1.30e-05

Plasmodium falciparum uncharacterized domain TIGR01639; This model represents a conserved sequence region of about 60 amino acids found in over 40 predicted proteins of Plasmodium falciparum. It is not found elsewhere, including closely related species such as Plasmodium yoelii. No member of this family is characterized.


Pssm-ID: 130700  Cd Length: 61  Bit Score: 41.47  E-value: 1.30e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 124805371  149 KYYDTLEQWNEEKIQNKLDKLDDIHSKLDKLIIWAQIQGSERLKTYSMVYTLRRLFKSL 207
Cdd:TIGR01639   2 KYNDLSKKLTKEELNEMINSLDEIPNRNDMLIIWNQVHGIERDKFVKMQENLKEYIQKL 60
PTZ00131 PTZ00131
glycophorin-binding protein; Provisional
 10-89 1.32e-04

glycophorin-binding protein; Provisional


Pssm-ID: 185467 [Multi-domain]  Cd Length: 413  Bit Score: 42.06  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805371  10 ISNSARLNNKSVNSKNCTIYSFEqdEENRRNLSSRLLSTMHSS--ITILGVIFILILNVCLTKESSSSLIQINFNNSRKL 87
Cdd:PTZ00131   9 IKSAGDSNCKNFNSKNSSKYSLM--DVQEKNEKKNSLGAFHSKkiILIFGIIYVALLNAYICGDKYEKAADYGFREGRIL 86


                 ..
gi 124805371  88 AD 89
Cdd:PTZ00131  87 AE 88
PRESAN pfam09687
Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium ...
 156-219 3.37e-04

Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localize to membranes.


Pssm-ID: 430754  Cd Length: 125  Bit Score: 39.18  E-value: 3.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124805371  156 QWNEEKIQNKLDKLDDIHSKLDKLIIWAQIQGSERLKTYSMVYTLRRLFKSLLKEYNLKQKDKE 219
Cdd:pfam09687   1 NLTEEEINKKINSLNEVVSKKDMYIIWNYVNKNEKKKYYNMIEKLWKYFEELAKKYNIPEEYKK 64
 
Name Accession Description Interval E-value
P_fal_TIGR01639 TIGR01639
Plasmodium falciparum uncharacterized domain TIGR01639; This model represents a conserved ...
 149-207 1.30e-05

Plasmodium falciparum uncharacterized domain TIGR01639; This model represents a conserved sequence region of about 60 amino acids found in over 40 predicted proteins of Plasmodium falciparum. It is not found elsewhere, including closely related species such as Plasmodium yoelii. No member of this family is characterized.


Pssm-ID: 130700  Cd Length: 61  Bit Score: 41.47  E-value: 1.30e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 124805371  149 KYYDTLEQWNEEKIQNKLDKLDDIHSKLDKLIIWAQIQGSERLKTYSMVYTLRRLFKSL 207
Cdd:TIGR01639   2 KYNDLSKKLTKEELNEMINSLDEIPNRNDMLIIWNQVHGIERDKFVKMQENLKEYIQKL 60
PTZ00131 PTZ00131
glycophorin-binding protein; Provisional
 10-89 1.32e-04

glycophorin-binding protein; Provisional


Pssm-ID: 185467 [Multi-domain]  Cd Length: 413  Bit Score: 42.06  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805371  10 ISNSARLNNKSVNSKNCTIYSFEqdEENRRNLSSRLLSTMHSS--ITILGVIFILILNVCLTKESSSSLIQINFNNSRKL 87
Cdd:PTZ00131   9 IKSAGDSNCKNFNSKNSSKYSLM--DVQEKNEKKNSLGAFHSKkiILIFGIIYVALLNAYICGDKYEKAADYGFREGRIL 86


                 ..
gi 124805371  88 AD 89
Cdd:PTZ00131  87 AE 88
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 1-87 2.24e-04

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 41.70  E-value: 2.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124805371    1 MRSLKTPGYISNSARLNNKSVNSKNCTIYSFEQDEENRRNLSS-RLLSTMHSSITILGVIFILILNVCLTKESSSSLIQI 79
Cdd:PTZ00341    1 MKPFHAYSSAFSKQYMDTKNVKAKNPTIYSFDDEEKQNENKSFlKSLCSKRGVLPIIGILYIILNGNFGYNGSSNSGAQF 80


                  ....*...
gi 124805371   80 NFNNSRKL 87
Cdd:PTZ00341   81 TDRCSRNL 88
PRESAN pfam09687
Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium ...
 156-219 3.37e-04

Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localize to membranes.


Pssm-ID: 430754  Cd Length: 125  Bit Score: 39.18  E-value: 3.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124805371  156 QWNEEKIQNKLDKLDDIHSKLDKLIIWAQIQGSERLKTYSMVYTLRRLFKSLLKEYNLKQKDKE 219
Cdd:pfam09687   1 NLTEEEINKKINSLNEVVSKKDMYIIWNYVNKNEKKKYYNMIEKLWKYFEELAKKYNIPEEYKK 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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