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Conserved domains on  [gi|297491095|ref|XP_002698636|]
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olfactory receptor 13A1 [Bos taurus]

Protein Classification

7tmA_OR13-like domain-containing protein( domain architecture ID 11607068)

7tmA_OR13-like domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
36-305 2.71e-157

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 440.54  E-value: 2.71e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15232    1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15232   81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15232  161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15232  241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
 
Name Accession Description Interval E-value
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
36-305 2.71e-157

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 440.54  E-value: 2.71e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15232    1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15232   81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15232  161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15232  241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
42-315 1.31e-44

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 153.81  E-value: 1.31e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095   42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  122 ELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLLLSCS 201
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  202 PTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISP--ASSYSP 279
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHrfGHNVPP 240
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 297491095  280 ERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGRL 315
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
38-160 6.61e-04

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 40.92  E-value: 6.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLytvALMGNAVIIAVGSHSaSLQSPMYFFLCNLAAMDIVCTSsVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:PHA03087  46 VYSTIFFF---GLVGNIIVIYVLTKT-KIKTPMDIYLLNLAVSDLLFVM-TLPFQIYYYILFQWSFGEFACKIVSGLYYI 120
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVW 160
Cdd:PHA03087 121 GFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIW 163
 
Name Accession Description Interval E-value
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
36-305 2.71e-157

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 440.54  E-value: 2.71e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15232    1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15232   81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15232  161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15232  241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-305 9.13e-128

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 365.65  E-value: 9.13e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd13954    1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd13954   81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd13954  161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd13954  241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
36-312 4.39e-117

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 339.05  E-value: 4.39e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15225    1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15225   81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15225  161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15225  241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
37-305 8.01e-114

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 330.62  E-value: 8.01e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  37 PLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLT 116
Cdd:cd15230    2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 117 WSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLL 196
Cdd:cd15230   82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 197 LLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASS 276
Cdd:cd15230  162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241
                        250       260
                 ....*....|....*....|....*....
gi 297491095 277 YSPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15230  242 YSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
37-312 4.12e-111

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 323.79  E-value: 4.12e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  37 PLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLT 116
Cdd:cd15235    3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 117 WSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLL 196
Cdd:cd15235   83 AFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 197 LLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASS 276
Cdd:cd15235  163 KLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSS 242
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 297491095 277 YSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15235  243 YSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
36-305 8.82e-109

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 317.50  E-value: 8.82e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15911    1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15911   81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15911  161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15911  241 NTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
39-305 2.28e-108

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 316.70  E-value: 2.28e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  39 FCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWS 118
Cdd:cd15227    4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 119 ASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLLL 198
Cdd:cd15227   84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 199 SCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSYS 278
Cdd:cd15227  164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243
                        250       260
                 ....*....|....*....|....*..
gi 297491095 279 PERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15227  244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
22-316 3.33e-108

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 317.38  E-value: 3.33e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  22 EFVLQGFSELPRLRLPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEEN 101
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 102 TISFPGCMAQLFFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCG 181
Cdd:cd15943   81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 182 PNVIAHFFCEIPPLLLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSV 261
Cdd:cd15943  161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 297491095 262 YYSAVFCAYISPASSYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGRLV 316
Cdd:cd15943  241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
38-312 4.31e-108

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 316.13  E-value: 4.31e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15231    3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15231   83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15231  163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15231  243 SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
23-309 5.56e-107

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 313.87  E-value: 5.56e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  23 FVLQGFSELPRLRLPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENT 102
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 103 ISFPGCMAQLFFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGP 182
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 183 NVIAHFFCEIPPLLLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVY 262
Cdd:cd15408  161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 297491095 263 YSAVFCAYISPASSYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIK 309
Cdd:cd15408  241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
36-314 9.41e-107

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 313.04  E-value: 9.41e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15417    1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15417   81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15417  161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGR 314
Cdd:cd15417  241 SHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
38-305 1.29e-104

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 307.23  E-value: 1.29e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVII-AVGSHSaSLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLT 116
Cdd:cd15918    3 LFGLFLGMYLVTVLGNLLIIlAIGSDS-HLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 117 WSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLL 196
Cdd:cd15918   82 LFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 197 LLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASS 276
Cdd:cd15918  162 KLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSS 241
                        250       260
                 ....*....|....*....|....*....
gi 297491095 277 YSPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15918  242 HSASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
37-312 2.00e-103

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 304.52  E-value: 2.00e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  37 PLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIvCTSSV-LPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15229    2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDI-CYSSVtVPKMLENLLSERKTISVEGCIAQIFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15229   81 FFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15229  161 LPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNS 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15229  241 ASSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
36-305 2.95e-103

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 303.64  E-value: 2.95e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15912    1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15912   81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15912  161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15912  241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
23-316 3.00e-102

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 301.89  E-value: 3.00e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  23 FVLQGFSELPRLRLPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENT 102
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 103 ISFPGCMAQLFFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGP 182
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 183 NVIAHFFCEIPPLLLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVY 262
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 297491095 263 YSAVFCAYISPASSYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGRLV 316
Cdd:cd15410  241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
36-314 3.17e-102

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 301.54  E-value: 3.17e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15411    1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15411   81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15411  161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGR 314
Cdd:cd15411  241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
36-314 4.62e-101

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 298.45  E-value: 4.62e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15419    1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15419   81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15419  161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGR 314
Cdd:cd15419  241 VSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
27-316 1.63e-100

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 297.36  E-value: 1.63e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  27 GFSELPRLRLPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFP 106
Cdd:cd15406    1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 107 GCMAQLFFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIA 186
Cdd:cd15406   81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 187 HFFCEIPPLLLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAV 266
Cdd:cd15406  161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 297491095 267 FCAYISPASSYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGRLV 316
Cdd:cd15406  241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
37-314 1.55e-99

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 294.70  E-value: 1.55e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  37 PLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLT 116
Cdd:cd15409    2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 117 WSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLL 196
Cdd:cd15409   82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 197 LLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASS 276
Cdd:cd15409  162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 297491095 277 YSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGR 314
Cdd:cd15409  242 YALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
38-312 1.06e-98

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 292.15  E-value: 1.06e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15421    3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15421   83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15421  163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15421  243 SPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
23-314 1.75e-95

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 284.71  E-value: 1.75e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  23 FVLQGFSELPRLRLPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENT 102
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 103 ISFPGCMAQLFFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGP 182
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 183 NVIAHFFCEIPPLLLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVY 262
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 297491095 263 YSAVFCAYISPASSYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGR 314
Cdd:cd15945  241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
37-305 5.46e-94

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 279.88  E-value: 5.46e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  37 PLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLT 116
Cdd:cd15431    2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 117 WSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAgLMTRLSFCGPNVIAHFFCEIPPLL 196
Cdd:cd15431   82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPV-LTMPLHFCGPNVINHFFCEVQALL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 197 LLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASS 276
Cdd:cd15431  161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240
                        250       260
                 ....*....|....*....|....*....
gi 297491095 277 YSPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15431  241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
36-305 1.29e-93

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 279.12  E-value: 1.29e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15947    1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15947   81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15947  161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15947  241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
38-312 2.39e-93

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 278.83  E-value: 2.39e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15420    3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15420   83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15420  163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15420  243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
36-312 6.91e-93

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 277.74  E-value: 6.91e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15412    1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15412   81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15412  161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15412  241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQAL 277
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
37-314 1.51e-92

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 276.90  E-value: 1.51e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  37 PLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQL-FFL 115
Cdd:cd15413    2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLaFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASsELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15413   82 TFIIS-ELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15413  161 LALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKS 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGR 314
Cdd:cd15413  241 SHSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
36-305 2.57e-92

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 275.69  E-value: 2.57e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15237    1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15237   81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15237  161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15237  241 THSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
37-312 6.52e-92

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 275.22  E-value: 6.52e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  37 PLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLT 116
Cdd:cd15234    2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 117 WSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLL 196
Cdd:cd15234   82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 197 LLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASS 276
Cdd:cd15234  162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 297491095 277 YSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15234  242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
37-314 3.03e-90

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 270.82  E-value: 3.03e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  37 PLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLT 116
Cdd:cd15415    2 PLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 117 WSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLL 196
Cdd:cd15415   82 VFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 197 LLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASS 276
Cdd:cd15415  162 KLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQ 241
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 297491095 277 YSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGR 314
Cdd:cd15415  242 YSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
36-314 6.22e-90

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 270.01  E-value: 6.22e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15416    1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15416   81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15416  161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGR 314
Cdd:cd15416  241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
36-317 2.21e-88

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 266.21  E-value: 2.21e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15414    1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15414   81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15414  161 LSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSS 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGRLVQ 317
Cdd:cd15414  241 SSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIR 282
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
38-305 7.12e-88

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 264.55  E-value: 7.12e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15915    3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15915   83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRM-RSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASS 276
Cdd:cd15915  163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242
                        250       260
                 ....*....|....*....|....*....
gi 297491095 277 YSPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15915  243 DSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
36-312 1.26e-87

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 264.28  E-value: 1.26e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGN---AVIIAVGSHsasLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQL 112
Cdd:cd15407    1 IPLFIIFTLIYLITLVGNlgmILLILLDSR---LHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQM 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 113 FFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEI 192
Cdd:cd15407   78 FFFVVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 193 PPLLLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYIS 272
Cdd:cd15407  158 PPVLALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQ 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 297491095 273 PASSYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15407  238 PSSSHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAF 277
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
38-305 4.46e-86

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 259.91  E-value: 4.46e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15224    3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15224   83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15224  163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242
                        250       260
                 ....*....|....*....|....*...
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15224  243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
23-316 7.84e-86

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 260.10  E-value: 7.84e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  23 FVLQGFSELPRLRLPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENT 102
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 103 ISFPGCMAQLFFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGP 182
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 183 NVIAHFFCEIPPLLLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVY 262
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 297491095 263 YSAVFCAYISPASSYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGRLV 316
Cdd:cd15944  241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
38-312 5.19e-85

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 257.69  E-value: 5.19e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15434    3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15434   83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15434  163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSV 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15434  243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
38-305 6.72e-85

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 256.76  E-value: 6.72e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15939    3 CFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15939   83 FGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASiLRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15939  163 LACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241
                        250       260
                 ....*....|....*....|....*...
gi 297491095 278 SPErsKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15939  242 PID--KVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
38-312 3.90e-84

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 255.40  E-value: 3.90e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15429    3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15429   83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15429  163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15429  243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
36-312 7.17e-83

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 251.95  E-value: 7.17e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15405    1 IPLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15405   81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15405  161 LQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSS 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15405  241 VGSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
38-305 2.30e-82

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 250.37  E-value: 2.30e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15430    3 LFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15430   83 MGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15430  163 LACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKN 242
                        250       260
                 ....*....|....*....|....*...
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15430  243 AQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
35-315 2.82e-82

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 250.85  E-value: 2.82e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  35 RLPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFF 114
Cdd:cd15418    1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 115 LTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPP 194
Cdd:cd15418   81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 195 LLLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPA 274
Cdd:cd15418  161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 297491095 275 SSYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGRL 315
Cdd:cd15418  241 SSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
38-312 1.53e-81

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 248.55  E-value: 1.53e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15233    3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15233   83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15233  163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15233  243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
36-312 2.20e-81

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 248.16  E-value: 2.20e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15432    1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15432   81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15432  161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15432  241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
37-312 2.53e-81

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 248.13  E-value: 2.53e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  37 PLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVG-LAFEENTISFPGCMAQLFFL 115
Cdd:cd15916    2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGfLEPGGKVISFGGCVAQLYFF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15916   82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15916  162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 297491095 276 SYSPERskVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15916  242 KEALDG--VIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
38-312 6.03e-80

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 244.65  E-value: 6.03e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15424    3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15424   83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15424  163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15424  243 TPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
36-305 1.13e-79

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 243.65  E-value: 1.13e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15226    1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15226   81 HFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASIlRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15226  161 IKLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFS 239
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 276 SYSPErsKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15226  240 TFPVD--KFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
38-312 2.93e-78

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 240.03  E-value: 2.93e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15228    3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALcalnGSLHAGLMTRLSF----CGPNVIAHFFCEIP 193
Cdd:cd15228   83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWIT----SSFHATILTSLTFtlpyCGSNVVDYFFCDIF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 194 PLLLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISP 273
Cdd:cd15228  159 PVLKLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQP 238
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 297491095 274 ASsySPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15228  239 TP--SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
38-305 1.55e-77

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 238.04  E-value: 1.55e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15914    3 LFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15914   83 LGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15914  163 LACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSY 242
                        250       260
                 ....*....|....*....|....*...
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15914  243 SLDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
37-305 7.64e-76

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 233.75  E-value: 7.64e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  37 PLFCCFFS-LYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15913    1 ILLFSFFSvIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15913   81 FSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15913  161 LALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGS 240
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15913  241 GNSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
39-312 1.11e-75

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 233.89  E-value: 1.11e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  39 FCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWS 118
Cdd:cd15236    4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 119 ASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLLL 198
Cdd:cd15236   84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 199 SCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSYS 278
Cdd:cd15236  164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243
                        250       260       270
                 ....*....|....*....|....*....|....
gi 297491095 279 PERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15236  244 SDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
36-305 1.39e-75

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 233.10  E-value: 1.39e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15940    1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15940   81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASiLRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15940  161 IKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVS-LRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST 239
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 276 SYSPErsKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15940  240 SFSED--KVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
38-312 2.62e-75

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 232.76  E-value: 2.62e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15428    3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15428   83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15428  163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSST 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15428  243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
36-312 4.88e-75

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 231.94  E-value: 4.88e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15942    1 APLFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15942   81 HFLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15942  161 LKLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGS 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 297491095 276 SYSpeRSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15942  241 QDP--LDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
38-312 4.80e-74

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 229.35  E-value: 4.80e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVII-AVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGL-AFEENTISFPGCMAQLFFL 115
Cdd:cd15941    3 FFLLFLLIYLLTVLGNLLILlTIGSDPHLHGLPMYHFLGHLSFLDACLSSVTVPKVLAGLlTLSGRTISFEGCVVQLYAF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15941   83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15941  163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 297491095 276 SYSPerSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15941  243 SQAG--AGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
38-312 2.65e-73

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 227.75  E-value: 2.65e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15433    3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15433   83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15433  163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRY 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15433  243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
36-305 6.48e-73

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 226.06  E-value: 6.48e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15936    1 FFLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWalcaLNGSLHA----GLMTRLSFCGPNVIAHFFCE 191
Cdd:cd15936   81 HFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSW----LGGFAHSivqvALLLQLPFCGPNVLDNFYCD 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 192 IPPLLLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASIlRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYI 271
Cdd:cd15936  157 VPQVIKLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKI-RTHVTEGKRKALSTCASQITVVTLIFVPCIYIYA 235
                        250       260       270
                 ....*....|....*....|....*....|....
gi 297491095 272 SPASSYSPErsKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15936  236 RPFQTFPMD--KAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
38-305 3.71e-70

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 219.27  E-value: 3.71e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15946    3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15946   83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15946  163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242
                        250       260
                 ....*....|....*....|....*...
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15946  243 SPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
38-305 2.19e-69

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 217.05  E-value: 2.19e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15938    3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15938   83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIvasILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASSY 277
Cdd:cd15938  163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239
                        250       260
                 ....*....|....*....|....*...
gi 297491095 278 SPErsKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15938  240 PVD--KHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
36-305 2.12e-68

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 214.63  E-value: 2.12e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIA-VGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFF 114
Cdd:cd15935    1 LLLFVLVLACYAAILLGNLLIVVtVHADPHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 115 LTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPP 194
Cdd:cd15935   81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 195 LLLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASiLRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPA 274
Cdd:cd15935  161 VIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPF 239
                        250       260       270
                 ....*....|....*....|....*....|.
gi 297491095 275 SSYSpeRSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15935  240 SSSS--VDKVASVFYTLITPALNPLIYTLRN 268
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
38-312 1.56e-66

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 210.23  E-value: 1.56e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15223    3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLL 197
Cdd:cd15223   83 FTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 LSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYIS--PAS 275
Cdd:cd15223  163 LACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTyrFGK 242
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15223  243 TIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
36-305 2.43e-64

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 204.20  E-value: 2.43e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15937    1 LLLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15937   81 HFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASiLRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPAS 275
Cdd:cd15937  161 IKLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFR 239
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 276 SYSPErsKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd15937  240 SFPMD--KVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
42-308 1.03e-55

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 182.49  E-value: 1.03e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:cd15917    7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLLLSCS 201
Cdd:cd15917   87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 202 PTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISP--ASSYSP 279
Cdd:cd15917  167 DTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHrfGHHVPP 246
                        250       260
                 ....*....|....*....|....*....
gi 297491095 280 ERSKVSAVLYTMLSPTLNPIVYSLRNTEI 308
Cdd:cd15917  247 HVHILLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
42-308 1.65e-55

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 181.84  E-value: 1.65e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:cd15950    7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLLLSCS 201
Cdd:cd15950   87 ESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 202 PTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYY-SAVFCAYISPASSYSPE 280
Cdd:cd15950  167 DPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYiPGLLSIYTQRFGQGVPP 246
                        250       260
                 ....*....|....*....|....*....
gi 297491095 281 RSKV-SAVLYTMLSPTLNPIVYSLRNTEI 308
Cdd:cd15950  247 HTQVlLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
42-308 2.46e-55

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 181.33  E-value: 2.46e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:cd15221    7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWA--LCALNGSLHagLMTRLSFCGPNVIAHFFCEIPPLLLLS 199
Cdd:cd15221   87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVArsFCIVFPFVF--LLKRLPYCGHNVIPHTYCEHMGIARLA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 200 CSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISP--ASSY 277
Cdd:cd15221  165 CADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHrfGRHI 244
                        250       260       270
                 ....*....|....*....|....*....|.
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRNTEI 308
Cdd:cd15221  245 PRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
42-308 2.60e-53

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 176.15  E-value: 2.60e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:cd15222    7 FCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALngsLHA---GLMTRLSFCGPNVIAHFFCEIPPLLLL 198
Cdd:cd15222   87 ESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVL---LLLplpFLLKRLPFCHSNVLSHSYCLHQDVMKL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 199 SCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYI--SPASS 276
Cdd:cd15222  164 ACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMvhRFGKH 243
                        250       260       270
                 ....*....|....*....|....*....|..
gi 297491095 277 YSPERSKVSAVLYTMLSPTLNPIVYSLRNTEI 308
Cdd:cd15222  244 ASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
42-308 1.28e-51

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 171.79  E-value: 1.28e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:cd15952    7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSRMSPRLcrslaVGVWALCALNGSL-----HAGLMTRLSFCGPNVIAHFFCEIPPLL 196
Cdd:cd15952   87 ESAVLVAMAFDRYVAICNPLRYTTILTNKV-----ISVIALGIVLRPLllvlpFVFLILRLPFCGHNIIPHTYCEHMGIA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 197 LLSCSPTLVNSIMTVLADAFYgVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISPASS 276
Cdd:cd15952  162 KLACASIRINIIYGLFAISVL-VLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFG 240
                        250       260       270
                 ....*....|....*....|....*....|....
gi 297491095 277 YSPERSK--VSAVLYTMLSPTLNPIVYSLRNTEI 308
Cdd:cd15952  241 HNIPRYIhiLLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
42-308 1.25e-50

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 169.06  E-value: 1.25e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:cd15951    7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLLLSCS 201
Cdd:cd15951   87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 202 PTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISP--ASSYSP 279
Cdd:cd15951  167 DTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHrfGHNVPP 246
                        250       260
                 ....*....|....*....|....*....
gi 297491095 280 ERSKVSAVLYTMLSPTLNPIVYSLRNTEI 308
Cdd:cd15951  247 HVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
42-308 1.55e-50

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 168.98  E-value: 1.55e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:cd15953    7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSRMS-PRLCRSLAVGVW--ALCALNGSLhagLMTRLSFCGPNVIAHFFCEIPPLLLL 198
Cdd:cd15953   87 ESAVLVAMAFDRYVAICNPLRYATILTnSRIAKLGLVGLIrgVLLILPLPL---LLSRLPFCANRIIPHTYCEHMAVVKL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 199 SCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISP--ASS 276
Cdd:cd15953  164 ACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHrfGQG 243
                        250       260       270
                 ....*....|....*....|....*....|..
gi 297491095 277 YSPERSKVSAVLYTMLSPTLNPIVYSLRNTEI 308
Cdd:cd15953  244 IAPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
42-309 2.21e-46

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 158.14  E-value: 2.21e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:cd15948    8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLLLSCS 201
Cdd:cd15948   88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACG 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 202 PTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYI--SPASSYSP 279
Cdd:cd15948  168 DTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTmhRFARHVAP 247
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 280 ERSKVSAVLYTMLSPTLNPIVYSLRNTEIK 309
Cdd:cd15948  248 HVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
42-315 1.31e-44

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 153.81  E-value: 1.31e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095   42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  122 ELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLLLSCS 201
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  202 PTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISP--ASSYSP 279
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHrfGHNVPP 240
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 297491095  280 ERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHALGRL 315
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
42-308 4.07e-42

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 146.93  E-value: 4.07e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:cd15956    7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSRMSpRLCRSLAVGVWALCALNGSLHAGLMT-RLSFCGPNVIAHFFCEIPPLLLLSC 200
Cdd:cd15956   87 ESGVLVAMALDRFVAICNPLHYATILT-LEVVAKAGLLLALRGVAIVIPFPLLVcRLSFCASHTIAHTYCEHMAVVKLAC 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 201 SPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISP--ASSYS 278
Cdd:cd15956  166 GATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHrfGHSVP 245
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 279 PERSKVSAVLYTMLSPTLNPIVYSLRNTEI 308
Cdd:cd15956  246 SAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
42-308 1.85e-39

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 140.34  E-value: 1.85e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:cd15954    7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPLLLLSCS 201
Cdd:cd15954   87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 202 PTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISP---ASSYS 278
Cdd:cd15954  167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHrfgGHHIT 246
                        250       260       270
                 ....*....|....*....|....*....|
gi 297491095 279 PERSKVSAVLYTMLSPTLNPIVYSLRNTEI 308
Cdd:cd15954  247 PHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
23-309 2.65e-39

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 140.30  E-value: 2.65e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  23 FVLQGFSELPRLRLPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENT 102
Cdd:cd15949    4 FILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 103 ISFPGCMAQLFFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSprlcRSLAVGVWALCALNGSLHAG----LMTRLS 178
Cdd:cd15949   84 IPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILT----NTTVIRIGLAAVIRGVLYISplplLVRRLP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 179 FCGPNVIAHFFCEIPPLLLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLV 258
Cdd:cd15949  160 WYRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCA 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 297491095 259 VSVYYSAVFCAYISP--ASSYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIK 309
Cdd:cd15949  240 ILAFYVPIAVSSLIHrfGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
42-308 1.11e-37

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 135.67  E-value: 1.11e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:cd15955    7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMT-RLSFCGPNVIAHFFCEIPPLLLLSC 200
Cdd:cd15955   87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMAVVKLAA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 201 SPTLVNSIMTV-LADAFYGVlNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYYSAVFCAYISP--ASSY 277
Cdd:cd15955  167 DDVRVNKIYGLfVAFSILGF-DIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHrfGHHV 245
                        250       260       270
                 ....*....|....*....|....*....|.
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRNTEI 308
Cdd:cd15955  246 APYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
52-301 1.26e-33

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 124.34  E-value: 1.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095   52 GNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEEN-TISFPGCMAQLFFLTWSASSELLLLTAMA 130
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFGLLTLPFWLVYYLLHGDwPFGSALCKLVGALFYVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  131 YDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNviaHFFCEIPPLLLLSCSPTLVNSIMT 210
Cdd:pfam00001  81 IDRYLAIVHPLRYRRIRTPRRAKVLILLVWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEVLSKPVSYTLLSSV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  211 VLadafyGVLNFLLTLVSYGCIVASILRMRSAAGR--------RRAFSTCSSHLLVVSVYYSAVFCAYISPASSYSPERS 282
Cdd:pfam00001 158 LG-----FLLPLLVILVCYTRIIRTLRKSASKQKSeertqrreRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELS 232
                         250       260
                  ....*....|....*....|....*
gi 297491095  283 KV------SAVLYTMLSPTLNPIVY 301
Cdd:pfam00001 233 RLldkalsITLWLAYVNSCLNPIIY 257
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
38-305 6.08e-24

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 98.90  E-value: 6.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCGPNVIAHFFCEIPPlll 197
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTL--- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 lscsptlvNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSH-----------LLVVSV----- 261
Cdd:cd00637  158 --------SKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRrrrerkvtktlLIVVVVfllcw 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 297491095 262 --YYSAVFCAYISPASSYSPERSKVSAVLYTMLSPTLNPIVYSLRN 305
Cdd:cd00637  230 lpYFILLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
38-312 3.95e-13

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 67.97  E-value: 3.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTV-ALMGNA-VIIAVGSHSaSLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd14967    1 LLAVFLSLIILvTVFGNLlVILAVYRNR-RLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLhaGLMTRLSFCGPNVIAHFFCEIPpl 195
Cdd:cd14967   80 VLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLP--PLVGWRDETQPSVVDCECEFTP-- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 lllscsptlvNSIMTVLADAFYGVLNFLLTLVSYGCIVasilrmRSAAGRRRAFSTCSshlLVVSV-------YYSAVFC 268
Cdd:cd14967  156 ----------NKIYVLVSSVISFFIPLLIMIVLYARIF------RVARRELKAAKTLA---IIVGAfllcwlpFFIIYLV 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 297491095 269 AYISPASSYSPERSKVSAVLyTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd14967  217 SAFCPPDCVPPILYAVFFWL-GYLNSALNPIIYALFNRDFRRAF 259
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
38-162 1.98e-12

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 66.47  E-value: 1.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSL-YTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLT 116
Cdd:cd14993    2 VLIVLYVVvFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQG 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 297491095 117 WSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd14993   82 VSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVI 127
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
45-248 7.38e-10

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 58.80  E-value: 7.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  45 LYTVALMGN--AVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAfeeNTISFPG----CMAQLFFLTWS 118
Cdd:cd14981   10 MFVFGVLGNllALIVLARSSKSHKWSVFYRLVAGLAITDLLGILLTSPVVLAVYA---SNFEWDGgqplCDYFGFMMSFF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 119 ASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLH-AGLMTRLSFCgpnviahffceipplll 197
Cdd:cd14981   87 GLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPlLGLGSYVLQY----------------- 149
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 297491095 198 lSCSPTLVNSIMTVLADAFY-------GVLNFLLTLVSYGCIVASILRMRSAAGRRRA 248
Cdd:cd14981  150 -PGTWCFLDFYSKNTGDAAYaylysilGLLILLVTLLCNLLVIITLLRMRRRKKRHRR 206
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
42-169 9.08e-10

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 58.27  E-value: 9.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLF------FL 115
Cdd:cd15103    7 FLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIdnvidsMI 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSL 169
Cdd:cd15103   87 CSSLLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGIL 140
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
37-175 9.18e-10

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 58.60  E-value: 9.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  37 PLFC-CFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALvGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15394    1 PLIIpLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTL-AYAFEPRGWVFGRFMCYFVFL 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 297491095 116 TWSAS--SELLLLTAMAYDRYVAICRPLHysSRMSPRLCRSLAVGVWaLCALNGSLHAGLMT 175
Cdd:cd15394   80 MQPVTvyVSVFTLTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIW-LLSCGLALPAAAHT 138
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
52-312 2.67e-09

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 57.22  E-value: 2.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  52 GNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLLTAMAY 131
Cdd:cd14969   17 LNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALAF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 132 DRYVAICRPLhYSSRMSPRLCRSLAVGVWALCalngslhaglmtrlsfcgpnviahFFCEIPPLL----------LLSCS 201
Cdd:cd14969   97 ERYLVIVRPL-KAFRLSKRRALILIAFIWLYG------------------------LFWALPPLFgwssyvpeggGTSCS 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 202 PTL----VNS---IMTVLADAFygVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSH-----------LLVVSVY- 262
Cdd:cd14969  152 VDWyskdPNSlsyIVSLFVFCF--FLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTkkaekkvakmvLVMIVAFl 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 297491095 263 -----YSAV-FCAYISPASSYSPERSKVSAVLyTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd14969  230 iawtpYAVVsLYVSFGGESTIPPLLATIPALF-AKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
40-312 1.91e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 54.61  E-value: 1.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  40 CCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLpKALVGLAFEENTISFPGCMAQLFFLTWSA 119
Cdd:cd14972    3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFV-FTFLSVLLVSLTPSPATWLLRKGSLVLSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 120 SSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLhaglmtrlsfcgPNVIAHffCEIPPllLLS 199
Cdd:cd14972   82 LASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALL------------PVLGWN--CVLCD--QES 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 200 CSPTL----VNSIMTVLADAFygvLNFLLTLVSYGCI--------VASILRMRSAAGRRRAFSTCSSH----LLVVSVYY 263
Cdd:cd14972  146 CSPLGpglpKSYLVLILVFFF---IALVIIVFLYVRIfwclwrhaNAIAARQEAAVPAQPSTSRKLAKtvviVLGVFLVC 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 297491095 264 SAVFCAYISpASSYSPERSKVSAVLYTMLSPTL-----NPIVYSLRNTEIKHAL 312
Cdd:cd14972  223 WLPLLILLV-LDVLCPSVCDIQAVFYYFLVLALlnsaiNPIIYAFRLKEMRRAV 275
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
45-162 2.26e-08

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 54.55  E-value: 2.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  45 LYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKAL-VGLAFEentISFPGCMAQLFFLTWSASSEL 123
Cdd:cd15069   10 IAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAItISLGFC---TDFHSCLFLACFVLVLTQSSI 86
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 297491095 124 LLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd15069   87 FSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVL 125
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
47-312 8.49e-08

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 52.63  E-value: 8.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  47 TVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISfpgcMAQLFFLTWSASSELLLL 126
Cdd:cd15962   12 TVIACENAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETIS----LITVGFLVASFTASVSSL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 127 TAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALcalngSLHAGLMTRLsfcGPNVIAHFfceipplllLSCSPT--L 204
Cdd:cd15962   88 LAITVDRYLSLYNALTYYSEKTVLGVHLMLAATWGV-----SLCLGLLPVL---GWNCLEER---------ASCSIVrpL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 205 VNSIMTVLADAFYGVLNFLLTLvsYGCIVASILRMRSAAGRRRAFSTCS---------SHLLVVSVYYSAV---FCAYIS 272
Cdd:cd15962  151 TKSNVTLLSASFFFIFILMLHL--YIKICKIVCRHAHQIALQQHFLTAShyvatkkgvSTLAIILGTFGASwlpFAIYCV 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 297491095 273 PASSYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15962  229 VGDHEYPAVYTYATLLPATYNSMINPIIYAYRNQEIQRSM 268
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
47-165 1.67e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 51.47  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  47 TVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDI-VCTSSVLPKALVGLafeenTISFPG----CMAQLFF--LTWSA 119
Cdd:cd15196   12 VLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLlVALFNVLPQLIWDI-----TYRFYGgdllCRLVKYLqvVGMYA 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 297491095 120 SSELLLLTAMayDRYVAICRPLHySSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15196   87 SSYVLVATAI--DRYIAICHPLS-SHRWTSRRVHLMVAIAWVLSLL 129
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
42-165 1.69e-07

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 51.46  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTValMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:cd15321   15 FLILFTI--FGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTS 92
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15321   93 SIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAV 136
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
42-169 1.76e-07

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 51.45  E-value: 1.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTI---SFPGCMAQLF--FLT 116
Cdd:cd15353    7 FVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTdaqSFTVNIDNVIdsVIC 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 297491095 117 WSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSL 169
Cdd:cd15353   87 SSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVL 139
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
42-312 2.79e-07

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 51.11  E-value: 2.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYT----VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQ--LFFL 115
Cdd:cd14982    3 FPIVYSlifiLGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTglLFYI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASseLLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALnGSLHAGLMTRLSFCGPNVIAHFfcEIPPL 195
Cdd:cd14982   83 NMYGS--ILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLV-ASVPLLLLRSTIAKENNSTTCF--EFLSE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 LLLScSPTLVNSIMTVLadafyGVLNFLLTLVSYGCIVASILRMRSAAG----RRRAFSTCSSHLLVVSVY---YSAVFC 268
Cdd:cd14982  158 WLAS-AAPIVLIALVVG-----FLIPLLIILVCYSLIIRALRRRSKQSQksvrKRKALRMILIVLAVFLVCflpYHVTRI 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 297491095 269 AYIS-----PASSYSPER---SKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd14982  232 LYLLvrlsfIADCSARNSlykAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
42-160 3.14e-07

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 50.95  E-value: 3.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLF------FL 115
Cdd:cd15351    7 FLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnvidtMI 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVW 160
Cdd:cd15351   87 CSSVVSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIW 131
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
47-303 3.47e-07

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 50.87  E-value: 3.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  47 TVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLL 126
Cdd:cd15336   12 ITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 127 TAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWaLCALNGSLhAGLMTRLSFcgpnviahffceIPPLLLLSCS----- 201
Cdd:cd15336   92 LAISLDRYLVITKPLASIRWVSKKRAMIIILLVW-LYSLAWSL-PPLFGWSAY------------VPEGLLTSCTwdymt 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 202 PTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSH----------------LLVVSVY--- 262
Cdd:cd15336  158 FTPSVRAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRSTGREVQKLGSQDRKEKAkqyqrmknewkmakiaFVVILLFvls 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 297491095 263 ---YSAV-FCAYISPASSYSPERSKVSAVLyTMLSPTLNPIVYSL 303
Cdd:cd15336  238 wspYACVaLIAWAGYAHLLTPYMKSVPAVI-AKASAIYNPIIYAI 281
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-177 4.74e-07

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 50.52  E-value: 4.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  45 LYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMD---------IVCTsSVLPKALVGLAfeentisfpGC--MAQLF 113
Cdd:cd14999    9 MCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADllylltipfYVST-YFLKKWYFGDV---------GCrlLFSLD 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 297491095 114 FLTWSASseLLLLTAMAYDRYVAICRPLHYSSRmSPRLCRSLAVGVWaLCALNGSLHAGLMTRL 177
Cdd:cd14999   79 FLTMHAS--IFTLTVMSTERYLAVVKPLDTVKR-SKSYRKLLAGVIW-LLSLLLTLPMAIMIRL 138
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
47-312 5.53e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 50.33  E-value: 5.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  47 TVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALV---GLafeenTISFPGC-MAQLFFLTWSASSE 122
Cdd:cd14968   12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILislGL-----PTNFHGClFMACLVLVLTQSSI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 123 LLLLtAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSL-----HAGLMTRLSFCGPNVIAHFF-------- 189
Cdd:cd14968   87 FSLL-AIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTpmfgwNNGAPLESGCGEGGIQCLFEevipmdym 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 190 -------CEIPPLLllscsptlvnsIMTVL-ADAFYGVLNFLltlvsyGCIVASILRMRSAAGRRRAFSTCSSHLLVVSV 261
Cdd:cd14968  166 vyfnffaCVLVPLL-----------IMLVIyLRIFRVIRKQL------RQIESLLRSRRSRSTLQKEVKAAKSLAIILFL 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 297491095 262 YysaVFC----------AYISPaSSYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd14968  229 F---ALCwlplhiinciTLFCP-ECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
48-165 1.09e-06

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 49.25  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLLT 127
Cdd:cd15083   13 IGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLA 92
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 297491095 128 AMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15083   93 AIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLL 130
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
42-167 1.09e-06

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 49.12  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLF------FL 115
Cdd:cd15352    7 FLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMdnvfdsMI 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNG 167
Cdd:cd15352   87 CISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCG 138
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
48-236 1.19e-06

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 49.27  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALV---------GLAFEENTISFPgcmaqlffLTWS 118
Cdd:cd15312   13 LTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVrsvescwyfGDLFCKIHSSLD--------MMLS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 119 ASSeLLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSlhaGLMtrlsFCGPNV--IAHFfceippLL 196
Cdd:cd15312   85 TTS-IFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAF---GVV----FSEVNLegIEDY------VA 150
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 297491095 197 LLSCSPTLVnsimtVLADAFYGVLNFLLTLVSYGCIVASI 236
Cdd:cd15312  151 LVSCTGSCV-----LIFNKLWGVIASLIAFFIPGTVMIGI 185
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
39-165 1.28e-06

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 49.03  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  39 FCCFFSLYTVAlmGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWS 118
Cdd:cd15054    6 FLCLIILLTVA--GNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMC 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 297491095 119 ASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15054   84 CSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAAL 130
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
45-165 1.44e-06

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 48.91  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  45 LYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDI-VCTSSVLPKaLVGLAFEENTISFPGC--MAQLFFLTWSASS 121
Cdd:cd14986   10 LFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLvVAFFTVLTQ-IIWEATGEWVAGDVLCriVKYLQVVGLFAST 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 297491095 122 elLLLTAMAYDRYVAICRPLhySSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd14986   89 --YILVSMSLDRYQAIVKPM--SSLKPRKRARLMIVVAWVLSFL 128
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
44-160 1.61e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 48.44  E-value: 1.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  44 SLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSEL 123
Cdd:cd15330    9 TLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSI 88
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 297491095 124 LLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVW 160
Cdd:cd15330   89 LHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTW 125
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
48-311 1.98e-06

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 48.26  E-value: 1.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLLT 127
Cdd:cd15063   13 LVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 128 AMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALcalngslhAGLMTRLSFCGPNVIAHFFCEIPPLLLLSCSPTLVNS 207
Cdd:cd15063   93 AISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVL--------SFVICFPPLVGWNDGKDGIMDYSGSSSLPCTCELTNG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 208 IMTVLADA---FYgvLNFLLTLVSYGCIVASIlRMRSAAGRRRA-----FSTCssHLLVVSVYYSAVFCAYISPASSYSp 279
Cdd:cd15063  165 RGYVIYSAlgsFY--IPMLVMLFFYFRIYRAA-RMETKAAKTVAiivgcFIFC--WLPFFTVYLVRAFCEDCIPPLLFS- 238
                        250       260       270
                 ....*....|....*....|....*....|....
gi 297491095 280 erskvsaVLYTM--LSPTLNPIVYSLRNTEIKHA 311
Cdd:cd15063  239 -------VFFWLgyCNSALNPCIYALFSRDFRFA 265
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
47-312 2.42e-06

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 47.97  E-value: 2.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  47 TVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFpgCMAQLFFLTWSASseLLLL 126
Cdd:cd15960   12 TVMACENAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGLIANFVAIYVMNSEAVTL--CSAGLLLAAFSAS--VCSL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 127 TAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHaglmtrlsfcgpnvIAHFFCEIPPLLLLSCSPTLVN 206
Cdd:cd15960   88 LAITVDRYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIGLLP--------------AMGWNCLRAPASCSVLRPVTKN 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 207 SiMTVLADAFYGVLNFLLTLVSYGCIVA-----------SILRMRSAAGRRRAFSTCSSHLLVVSVYYSAvFCAYISPAS 275
Cdd:cd15960  154 N-AAVLAVSFLLLFALMMQLYLQICRIAfrhaqqiavqhQFVNFCLASSTRKGVSTLSLILATFAFCWVP-FAVYSMVAD 231
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 297491095 276 SYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15960  232 SSYPMIYTYYLVLPAACNSVINPIIYAFRNPDIQKSL 268
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
38-168 2.54e-06

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 48.24  E-value: 2.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15205    3 FVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQST 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGS 168
Cdd:cd15205   83 AVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGS 133
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
52-165 2.80e-06

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 48.22  E-value: 2.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  52 GNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGC--MAQLFFLTWSASSELLllTAM 129
Cdd:cd15058   17 GNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCelWTSVDVLCVTASIETL--CVI 94
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 297491095 130 AYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15058   95 AVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSAL 130
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
36-165 2.87e-06

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 48.02  E-value: 2.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15322    1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALD 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15322   81 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAV 130
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
42-162 3.15e-06

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 48.15  E-value: 3.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:cd15208    7 YILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSV 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSrmSPRLCRSLAVGVWAL 162
Cdd:cd15208   87 SVLTLSCIALDRWYAICHPLMFKS--TAKRARVSILIIWIV 125
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
48-150 3.51e-06

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 47.45  E-value: 3.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMY-FFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLL 126
Cdd:cd15219   12 VSLLSNLLVLLCFLYSAELRKQVPgIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAMLSM 91
                         90       100
                 ....*....|....*....|....
gi 297491095 127 TAMAYDRYVAICRPLHYSSRMSPR 150
Cdd:cd15219   92 AALSIDRWIAVVFPLSYTSKMRYR 115
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
42-163 3.59e-06

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 47.62  E-value: 3.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMD-IVCTSSVLPKALVGLAFEENTI---SFPGCMAQLF--FL 115
Cdd:cd15354    7 FLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADmLVSVSNAWETITIYLLNNRHLViedAFVRHIDNVFdsLI 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALC 163
Cdd:cd15354   87 CISVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFC 134
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
49-169 3.74e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 47.75  E-value: 3.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  49 ALMGNAVIIAVGSHSASLQ-SPMYFFLCNLAAMDI-VCTSSVLPKALVGLAFEENTISFPgCMAQLFFLTWSASSELLLL 126
Cdd:cd15104   13 IITGNLLVIVALLKLIRKKdTKSNCFLLNLAIADFlVGLAIPGLATDELLSDGENTQKVL-CLLRMCFVITSCAASVLSL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 297491095 127 TAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSL 169
Cdd:cd15104   92 AAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFL 134
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
49-178 4.13e-06

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 47.51  E-value: 4.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  49 ALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLLTA 128
Cdd:cd15391   14 SVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTA 93
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 297491095 129 MAYDRYVAICRPLHysSRMSPRLCRSLAVGVWAlCALNGSLHAGLMTRLS 178
Cdd:cd15391   94 IGIDRFFAVIFPLR--SRHTKSRTKCIIASIWA-ISFSLSSVQLFAGRTQ 140
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
36-166 5.75e-06

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 47.21  E-value: 5.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGN-AVIIAVGSHSaSLQSPMYFFLCNLAAMDIVCTSSVLPKALVgLAFEENTIsFPGCMAQL-- 112
Cdd:cd15203    1 IILILLYGLIIVLGVVGNlLVIYVVLRNK-SMQTVTNIFILNLAVSDLLLCLVSLPFTLI-YTLTKNWP-FGSILCKLvp 77
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 297491095 113 -------FFLTWSasselllLTAMAYDRYVAICRPLhySSRMSPRLCRSLAVGVWALCALN 166
Cdd:cd15203   78 slqgvsiFVSTLT-------LTAIAIDRYQLIVYPT--RPRMSKRHALLIIALIWILSLLL 129
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
41-165 6.79e-06

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 46.86  E-value: 6.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  41 CFFSLYTVALMGNAVIIAVGSHSaSLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQL------FF 114
Cdd:cd14978    6 VLPVICIFGIIGNILNLVVLTRK-SMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFlpyiypLA 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 297491095 115 LTWSASSeLLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd14978   85 NTFQTAS-VWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLL 134
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
42-165 8.36e-06

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 46.47  E-value: 8.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTValMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASS 121
Cdd:cd15323    9 FLIVFTI--VGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTS 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15323   87 SIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAV 130
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
41-165 1.16e-05

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 46.15  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  41 CFFSLYTVA-LMGNAVIIAVGSHSASLQSPMY-FFLCNLAAMDIVCTSSVLP-KALVGLAFEENTISFpgCMAQLFFLTW 117
Cdd:cd15320    6 CFLSVLILStLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMPwKAVAEIAGFWPFGSF--CNIWVAFDIM 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15320   84 CSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVL 131
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
45-162 1.60e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 45.40  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  45 LYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELL 124
Cdd:cd15064   10 IILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASIL 89
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 297491095 125 LLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd15064   90 HLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTL 127
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
41-312 1.82e-05

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 45.52  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  41 CFFSLYTVALMGNAVIIAVGSHSASLQSpmYFFLCNLAAMDIVCTSSVLPKALVGLA--FEENTISFPGCMAQLFFLTWS 118
Cdd:cd15220    5 CMVLLDLTALVGNTAVMVVIAKTPHLRK--FAFVCHLCVVDLLAALLLMPLGILSSSpfFLGVVFGEAECRVYIFLSVCL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 119 ASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLhaGLMTRLSFCGPNVIAHFFCeippllLL 198
Cdd:cd15220   83 VSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLL--PVLGWPSYGGPAPIAARHC------SL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 199 SCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGcivaSILRMRSAAGRRRAFSTCSSHLLVVSVYYsavFCAYISPASSYS 278
Cdd:cd15220  155 HWSHSGHRGVFVVLFALVCFLLPLLLILVVYC----GVFKVFGGGKAALTLAAIVGQFLCCWLPY---FAFHLYSALAAS 227
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 297491095 279 PERSKVSAVLYTML---SPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15220  228 PVSGGEAEEVVTWLaysCFAVNPFFYGLLNRQIREEL 264
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
42-311 1.84e-05

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 45.54  E-value: 1.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPkalvglaFEENTISFPG-------CMAQLFF 114
Cdd:cd14971    7 FALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVP-------FTATIYPLPGwvfgdfmCKFVHYF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 115 LTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCalngslhaglmtrLSFCGPNVIAHFFCEIPP 194
Cdd:cd14971   80 QQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVS-------------LAVAAPVLALHRLRNYTP 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 195 LLLLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILR--------MRSAAGRRRAFSTCSSHLLVVSVYYSA- 265
Cdd:cd14971  147 GNRTVCSEAWPSRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRhlwrvavrPVLSEGSRRAKRKVTRLVLVVVVLFAAc 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 297491095 266 -------VFCAYISPAS-SYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHA 311
Cdd:cd14971  227 wgpihaiLLLVALGPFPlTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRKA 280
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
42-173 2.02e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 45.16  E-value: 2.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCT-SSVLPKALVGLA----------FEEntiSFPGCMA 110
Cdd:cd15350    7 FFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSlYKTLENILIILAdmgylnrrgpFET---KLDDIMD 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 297491095 111 QLFFLTWSASseLLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGL 173
Cdd:cd15350   84 SLFCLSLLGS--IFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGILMILF 144
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
38-162 2.50e-05

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 44.92  E-value: 2.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTV--ALMGNAVIIAVGShSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15335    2 LIVLTLALITIltTVLNSAVIAAICT-TKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVD 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd15335   81 MTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTI 127
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
36-165 2.72e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 45.04  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVAlmGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVgLAFEENTISFPGCMAQLF-- 113
Cdd:cd15067    2 LGVVLSLFCLVTVA--GNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSIL-HEMTGGYWLFGRDWCDVWhs 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 297491095 114 FLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15067   79 FDVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSAL 130
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
36-162 2.76e-05

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 44.98  E-value: 2.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLytVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDiVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd14970    3 IPAVYSVVCV--VGLTGNSLVIYVILRYSKMKTVTNIYILNLAVAD-ELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVD 79
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd14970   80 AYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWAL 126
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
46-162 2.83e-05

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 44.78  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  46 YTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLL 125
Cdd:cd15199   11 FGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLFMLSLSRGVSIAF 90
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 297491095 126 LTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd15199   91 LTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLL 127
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
38-169 2.94e-05

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 44.85  E-value: 2.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVAlmGN-AVIIAVgSHSASLQSPMYFFLCNLAAMDIvctssvlpkaLVGL---AFE----ENTISFPG-- 107
Cdd:cd15055    5 IVLSSISLLTVL--GNlLVIISI-SHFKQLHTPTNLLLLSLAVADF----------LVGLlvmPFSmirsIETCWYFGdt 71
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 297491095 108 -CMAQLFFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMS-PRLCRSLAVGvWALCALNGSL 169
Cdd:cd15055   72 fCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITiRRVKICICLC-WFVSALYSSV 134
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
42-251 3.18e-05

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 45.04  E-value: 3.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVctssVLpkaLVGLAFE--------ENTISFPGCMAQLF 113
Cdd:cd14979    7 YVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLL----IL---LVGLPVElynfwwqyPWAFGDGGCKLYYF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 114 FLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVW---ALCALNGSLHAGLMTRLSFCGPNVIAHFFC 190
Cdd:cd14979   80 LFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWlvsILCAIPILFLMGIQYLNGPLPGPVPDSAVC 159
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 297491095 191 EIPPllllscSPTLVNSIMTVLADAFYGVLNFLLTLVsYGCIVASILRMRSAAGRRRAFST 251
Cdd:cd14979  160 TLVV------DRSTFKYVFQVSTFIFFVLPMFVISIL-YFRIGVKLRSMRNIKKGTRAQGT 213
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
42-165 3.59e-05

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 44.65  E-value: 3.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLY-TVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVglafeeNTISFPGCMAQLFFLTWSA- 119
Cdd:cd15065    5 FLSLIiVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVV------NDLLGYWLFGETFCNIWISf 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 297491095 120 -----SSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15065   79 dvmcsTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSAL 129
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
38-311 4.66e-05

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 44.26  E-value: 4.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVAlmGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKA----LVGLAFEENTISfpgCMAQLF 113
Cdd:cd15053    5 LFLLLLPLLTVF--GNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAvyveVNGGKWYLGPIL---CDIYIA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 114 FLTWSASSELLLLTAMAYDRYVAICRPLHYS-SRMSPRLCRSLAVgVWALCALNGSlhaglmtrLSFCGPNViahffceI 192
Cdd:cd15053   80 MDVMCSTASIFNLCAISIDRYIAVTQPIKYArQKNSKRVLLTIAI-VWVVSAAIAC--------PLLFGLNN-------V 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 193 PPLLLLSCSptLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSA----AGRRRAFSTCSSHLLVVSVYYSavFC 268
Cdd:cd15053  144 PYRDPEECR--FYNPDFIIYSSISSFYIPCIVMLLLYYRIFRALRREKKAtktlAIVLGVFLFCWLPFFTLNILNA--IC 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 297491095 269 AYISPASSYSPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHA 311
Cdd:cd15053  220 PKLQNQSCHVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKA 262
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
38-150 5.32e-05

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 43.98  E-value: 5.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLA-----FEENTISFPGCMAQL 112
Cdd:cd15317    3 IYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVetcwyFGDLFCKFHTGLDLL 82
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 297491095 113 FFLTwsassELLLLTAMAYDRYVAICRPLHYSSRMSPR 150
Cdd:cd15317   83 LCTT-----SIFHLCFIAIDRYYAVCDPLRYPSKITVQ 115
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
38-305 5.33e-05

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 43.96  E-value: 5.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVctSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd14964    1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLL--ASLVVLVLFFLLGLTEASSRPQALCYLIYLLW 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 118 SASSELLLLTA--MAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAlngslhagLMTRLSFCGPNVIAHFFCEIppl 195
Cdd:cd14964   79 YGANLASIWTTlvLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSL--------LLSIPPLVGKGAIPRYNTLT--- 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 196 llLSCSPTLVNSIMTVLADAFYGVLNFLLTLVSYGCIV----ASILRMRSAAGR---------RRAFSTCSSHLLVVSVY 262
Cdd:cd14964  148 --GSCYLICTTIYLTWGFLLVSFLLPLVAFLVIFSRIVlrlrRRVRAIRSAASLntdknlkatKSLLILVITFLLCWLPF 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 297491095 263 YSAVFCAYISPASSYSPERSKVSAVLYtMLSPTLNPIVYSLRN 305
Cdd:cd14964  226 SIVFILHALVAAGQGLNLLSILANLLA-VLASTLNPFIYCLGN 267
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
48-195 5.38e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 44.16  E-value: 5.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKAL-VGLAFEENtisFPGCMAQLFFLTWSASSELLLL 126
Cdd:cd15068   13 LAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAItISTGFCAA---CHGCLFIACFVLVLTQSSIFSL 89
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 297491095 127 TAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNG----------SLHAGLMTRLSFCGPNVIAHFFCEIPPL 195
Cdd:cd15068   90 LAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGltpmlgwnncGQPKEGKNHSQGCGEGQVACLFEDVVPM 168
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
48-169 5.40e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 44.08  E-value: 5.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLA-----FEENTISFPGCMAQLFFLTwsassE 122
Cdd:cd15318   13 IIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVescwyFGDSFCRLHTCLDTLFCLT-----S 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 297491095 123 LLLLTAMAYDRYVAICRPLHYSSRMSPRL-CRSLAVGvWALCALNGSL 169
Cdd:cd15318   88 IFHLCFISIDRHCAICDPLLYPSKFTIRVaCIFIAAG-WLVPTVYTSV 134
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-165 6.87e-05

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 43.95  E-value: 6.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  45 LYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDI-VCTSSVLPKALVGLAFEENTISFpGCMAQLFFLTWSASSEL 123
Cdd:cd15197   10 LFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLcVGLINVLTDIIWRITVEWRAGDF-ACKVIRYLQVVVTYAST 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 297491095 124 LLLTAMAYDRYVAICRPLHYSSrmSPRLCRSLAVGVWALCAL 165
Cdd:cd15197   89 YVLVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILSAL 128
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
38-165 7.69e-05

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 43.41  E-value: 7.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVAlmGNA-VIIAVgSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLT 116
Cdd:cd15329    5 IVLLIIILGTVV--GNAlVIIAV-CLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDV 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 297491095 117 WSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15329   82 LLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSAL 130
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
48-162 9.26e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 43.38  E-value: 9.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFE-ENTISFPGCMAQLFFLTWSASSELLLL 126
Cdd:cd15304   13 LTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLFSTASIMHL 92
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 297491095 127 TAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd15304   93 CAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTI 128
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
52-144 9.63e-05

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 43.28  E-value: 9.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  52 GNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEEN-TISFPGCMAQLFFLTWSASSELLLLTAMA 130
Cdd:cd15306   17 GNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMwPLPLVLCPIWLFLDVLFSTASIMHLCAIS 96
                         90
                 ....*....|....
gi 297491095 131 YDRYVAICRPLHYS 144
Cdd:cd15306   97 LDRYIAIKKPIQAS 110
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
45-162 1.16e-04

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 42.96  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  45 LYTVALMGNA-VIIAVGSHSaSLQSPMYFFLCNLAAMDIVCTSSVLPKALVglaFEentISFPGCMAQLFFLTWSA---- 119
Cdd:cd15325   10 FILFGVLGNIlVILSVACHR-HLQTVTHYFIVNLAVADLLLTSTVLPFSAI---FE---ILGYWAFGRVFCNIWAAvdvl 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 297491095 120 --SSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd15325   83 ccTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVL 127
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
48-165 1.17e-04

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 42.97  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGC--MAQLFFLTWSASSELLl 125
Cdd:cd15959   13 VIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCelWTSVDVLCVTASIETL- 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 297491095 126 lTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15959   92 -CAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAA 130
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
45-165 1.34e-04

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 42.82  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  45 LYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSvLPKALVGLAFEENTIsFPGCMAQLF--FLTWSASSE 122
Cdd:cd15191   10 IFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLAT-LPLWATYYSYGYNWL-FGSVMCKICgsLLTLNLFAS 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 297491095 123 LLLLTAMAYDRYVAICRPLHySSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15191   88 IFFITCMSVDRYLAVVYPLR-SQRRRSWQARLVCLLVWVLACL 129
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
48-177 1.35e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 42.73  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLaFEENTISFPGCMAQL--FFLTWSASSELLL 125
Cdd:cd15392   13 LAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIAL-LILQYWPFGEFMCPVvnYLQAVSVFVSAFT 91
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 297491095 126 LTAMAYDRYVAICRPLhySSRMSPRLCRSLAVGVWALcALNGSLHAGLMTRL 177
Cdd:cd15392   92 LVAISIDRYVAIMWPL--RPRMTKRQALLLIAVIWIF-ALATALPIAITSRL 140
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
46-238 2.12e-04

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 42.38  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  46 YTVALMGNAVII-AVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELL 124
Cdd:cd15376   11 FLVAVLGNGLALwLFVTRERRPWHTGVVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFTCNLYGSIF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 125 LLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGslhaglMTRLSFCGPNVIAHFFCEippllllsCSPTL 204
Cdd:cd15376   91 FITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALS------APVLSFSHLEVERHNKTE--------CLGTA 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 297491095 205 VNSIM------TVLADAFYGVLNFLLTLVSYGCIVASILR 238
Cdd:cd15376  157 VDSRLptylpySLFLAVVGCGLPFLLTLASYLAIVWAVLR 196
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
48-165 2.24e-04

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 42.28  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLLT 127
Cdd:cd15390   13 VAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVAASVFTLM 92
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 297491095 128 AMAYDRYVAICRPLHysSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15390   93 AISIDRYIAIVHPLR--PRLSRRTTKIAIAVIWLASFL 128
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
48-177 2.29e-04

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 42.11  E-value: 2.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLLT 127
Cdd:cd15202   13 FSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTLT 92
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 297491095 128 AMAYDRYVAICRPLhySSRMSPRLCRSLAVGVWALcALNGSLHAGLMTRL 177
Cdd:cd15202   93 AIAVDRYQAIMHPL--KPRISKTKAKFIIAVIWTL-ALAFALPHAICSKL 139
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-165 2.37e-04

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 42.25  E-value: 2.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  40 CCFFSLY----TVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15125    1 CVIPSLYlliiTVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQ 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15125   81 LTSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVL 130
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
38-164 2.43e-04

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 42.18  E-value: 2.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIvCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15079    3 LGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDF-LMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSL 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHySSRMSPRLCRSLAVGVWALCA 164
Cdd:cd15079   82 SGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYAL 127
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
48-162 2.54e-04

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 42.05  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLLT 127
Cdd:cd14991   13 LGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNLFMLSVNRSASIAFLT 92
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 297491095 128 AMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd14991   93 AVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWAL 127
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
45-312 2.79e-04

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 42.09  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  45 LYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVcTSSVLPKALVGL-AFEENTISFPGCMAQLFFLTWSASSEL 123
Cdd:cd15928   10 LMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLL-IFLVLPLDLYRLwRYRPWRFGDLLCRLMYFFSETCTYASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 124 LLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGslhaglmtrlsfcGPNVIAHFFCEIP---PLLLLSC 200
Cdd:cd15928   89 LHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSA-------------GPALVLVGVEHIQgqqTPRGFEC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 201 SPTLVN----SIMTVLADAFYGVLNFLLTLVsYGCIVASIL----RMRSAAGRRR----------------AFSTC---- 252
Cdd:cd15928  156 TVVNVSsgllSVMLWVSTSFFFVPMVCLSLL-YGLIGRALWdrrqRSRTAGASRRdnnhrqtvrmlavivlAFVLCwlpf 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 297491095 253 -SSHLLVVSVYYSAVFCAYISPASSYsperskVSAVLYtMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15928  235 hVGRVIFNHSRASTKHLHYVSQYFNL------VSFVLF-YLSAAINPILYNLMSKRYRYAV 288
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
53-312 2.95e-04

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 41.69  E-value: 2.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  53 NAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISfpgcMAQLFFLTWSASSELLLLTAMAYD 132
Cdd:cd15100   18 NAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLGLILHFVFRYCVYSEALS----LVSVGLLVAAFSASVCSLLAITVD 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 133 RYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAglmtrlsfCGPNVIAHffceippllLLSCSPT--LVNSIMT 210
Cdd:cd15100   94 RYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPV--------LGWNCLRE---------GSSCSVVrpLTKNHLA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 211 VLADAFYGVLNFLLTLVSYGCIVA-----------SILRMRSAAGRRRAFSTCSshlLVVSVYYSA--VFCAYISPASSY 277
Cdd:cd15100  157 VLAVAFLLVFALMLQLYAQICRIVlrhahqialqrHFLAPSHYVATRKGVSTLA---LILGTFAACwiPFAVYCLLGDGS 233
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 297491095 278 SPERSKVSAVLYTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15100  234 SPALYTYATLLPATYNSMINPIIYAFRNQDIQKVL 268
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
41-165 3.70e-04

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 41.43  E-value: 3.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  41 CFFSL-YTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDI--VCTssvLPKALVGLAFEENTISFPgCMAQLFFLTW 117
Cdd:cd14984    5 VLYSLvFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLlfVLT---LPFWAVYAADGWVFGSFL-CKLVSALYTI 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd14984   81 NFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALL 128
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
49-162 4.04e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 41.32  E-value: 4.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  49 ALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLP--KALVGLAFEENTISFPGCMAQLFFLTWSASseLLLL 126
Cdd:cd15062   14 AIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPfsATLEVLGYWAFGRIFCDVWAAVDVLCCTAS--IMSL 91
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 297491095 127 TAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd15062   92 CVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVL 127
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
52-165 4.05e-04

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 41.17  E-value: 4.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  52 GN-AVIIAVGShSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLLTAMA 130
Cdd:cd15059   17 GNvLVIVAVLT-SRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCAIS 95
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 297491095 131 YDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15059   96 LDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAV 130
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
41-162 4.20e-04

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 41.24  E-value: 4.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  41 CFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSAS 120
Cdd:cd15393    6 LYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVN 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 297491095 121 SELLLLTAMAYDRYVAICRPLhySSRMSPRLCRSLAVGVWAL 162
Cdd:cd15393   86 VSVFTLTVIAVDRYRAVIHPL--KARCSKKSAKIIILIIWIL 125
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
34-237 4.98e-04

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 41.22  E-value: 4.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  34 LRLPLFCCFFSLytvALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLF 113
Cdd:cd15206    2 LIIPLYSVIFLL---AVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 114 FLTWSASSELLLLTAMAYDRYVAICRPLHysSRMSPRLCRSLAV--GVWALCALNGS---LHAGLMTRLSFCGPNVIAHF 188
Cdd:cd15206   79 FQAVSVSVSTFTLVAISLERYFAICHPLK--SRVWQTLSHAYKViaGIWLLSFLIMSpilVFSNLIPMSRPGGHKCREVW 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 297491095 189 FCEIppllllscsptlVNSIMTVLADAFYGVLNFLLTLVSYGCIVASIL 237
Cdd:cd15206  157 PNEI------------AEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLL 193
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
44-162 5.41e-04

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 41.09  E-value: 5.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  44 SLYTVALMG---NAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSAS 120
Cdd:cd15334    6 TLSILALMTtaiNSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCT 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 297491095 121 SELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd15334   86 CSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWII 127
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
34-141 5.62e-04

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 41.01  E-value: 5.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  34 LRLPLFCCFFSLytvALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLF 113
Cdd:cd15978    2 VRILLYSLIFLL---SVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATY 78
                         90       100
                 ....*....|....*....|....*...
gi 297491095 114 FLTWSASSELLLLTAMAYDRYVAICRPL 141
Cdd:cd15978   79 FMGISVSVSTFNLVAISLERYSAICKPL 106
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
38-165 5.85e-04

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 40.91  E-value: 5.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSvLPKALVGLAFEENTI--SFPGCMAQLFFL 115
Cdd:cd14988    3 LFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLT-LPVWMLEVMLDYTWLwgSFLCKFTHYFYF 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 297491095 116 TwSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd14988   82 A-NMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAI 130
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
42-200 6.24e-04

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 40.86  E-value: 6.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSL-YTVALMGNAVIIAVGSHSASLQ--SPMYFFLCNLAAMD----IVC-----TSSVLPKALVGLAFeentisfpgCM 109
Cdd:cd15098    6 VFGLiFCLGVLGNSLVITVLARVKPGKrrSTTNVFILNLSIADlfflLFCvpfqaTIYSLPEWVFGAFM---------CK 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 110 AQLFFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCrSLAVGV-WALCALNGS---LHAGLMTR-----LSFC 180
Cdd:cd15098   77 FVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNA-LLGVLViWVLSLAMASpvaVHQDLVHHwtasnQTFC 155
                        170       180       190
                 ....*....|....*....|....*....|.
gi 297491095 181 GPN-----------VIAHFFCEIPPLLLLSC 200
Cdd:cd15098  156 WENwpekqqkpvyvVCTFVFGYLLPLLLITF 186
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
48-162 6.30e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 40.90  E-value: 6.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDI----VCTSSVLPKALVGLAFEENTISfpgCMAQLFFLTWSASSEL 123
Cdd:cd15005   13 VSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGlrslACFPFVMASVRHGSGWIYGALS---CKVIAFLAVLFCFHSA 89
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 297491095 124 LLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd15005   90 FTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTL 128
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
38-160 6.61e-04

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 40.92  E-value: 6.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLytvALMGNAVIIAVGSHSaSLQSPMYFFLCNLAAMDIVCTSsVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:PHA03087  46 VYSTIFFF---GLVGNIIVIYVLTKT-KIKTPMDIYLLNLAVSDLLFVM-TLPFQIYYYILFQWSFGEFACKIVSGLYYI 120
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVW 160
Cdd:PHA03087 121 GFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIW 163
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
38-168 6.96e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 40.51  E-value: 6.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSL-YTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDI-VCTSSVLPKALVGLAFEENTISFPgCMAQLFFL 115
Cdd:cd15012    1 IFIILYTLvFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLcVGIFCVLQNLSIYLIPSWPFGEVL-CRMYQFVH 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGS 168
Cdd:cd15012   80 SLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNT 132
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
48-164 7.70e-04

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 40.49  E-value: 7.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLLT 127
Cdd:cd15073   13 ISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLT 92
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 297491095 128 AMAYDRYVAICRPLHYsSRMSPRLCRSLAVGVWALCA 164
Cdd:cd15073   93 VVAVDRYLTICRPDLG-RKMTTNTYTVMILLAWTNAF 128
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
48-162 8.76e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 40.26  E-value: 8.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPkalVGLAFEentISFPGCMAQLFFLTWSA------SS 121
Cdd:cd15326   13 FAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLP---FSATLE---ILGYWVFGRIFCDIWAAvdvlccTA 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 297491095 122 ELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd15326   87 SILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVL 127
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
44-165 8.81e-04

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 40.21  E-value: 8.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  44 SLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSEL 123
Cdd:cd15215    8 IFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGV 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 297491095 124 LLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15215   88 NTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVL 129
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
47-194 8.86e-04

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 40.49  E-value: 8.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  47 TVALMGNAVIIAVGSHSASLQSPMYFFLCNLA----AMDIVCTSSVLPKALVgLAFEENTISfpgCMAQLFFLTWSASSE 122
Cdd:cd14992   12 LVSVVGNFIVIAALARHKNLRGATNYFIASLAisdlLMALFCTPFNFTYVVS-LSWEYGHFL---CKIVNYLRTVSVYAS 87
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 297491095 123 LLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGS---LHAGLMTRLSFCGPNVIahFFCEIPP 194
Cdd:cd14992   88 SLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIpqlYYATTEVLFSVKNQEKI--FCCQIPP 160
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
41-175 9.11e-04

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 40.30  E-value: 9.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  41 CFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSAS 120
Cdd:cd15207    6 SYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQGVSVA 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 297491095 121 SELLLLTAMAYDRYVAICRPlhYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMT 175
Cdd:cd15207   86 ASVFTLVAIAVDRYRAVVHP--TEPKLTNRQAFVIIVAIWVLALAIMIPQALVLE 138
7tmA_PGI2 cd15141
prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...
45-165 9.26e-04

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.


Pssm-ID: 320269 [Multi-domain]  Cd Length: 301  Bit Score: 40.19  E-value: 9.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  45 LYTVALMGNAVIIAV-GSHSASLQ---SPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPG----CMAQLFFLT 116
Cdd:cd15141   10 MFAAGVVGNLLALGIlGVHRKERRtksSAFCVLVTGLAATDLLGTCFLSPMVFVSYAQNSSLLGLAAgqplCHLFAFAMT 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 297491095 117 WSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15141   90 FFGLASMLILFAMAVERCLAISHPYFYAQHSGRRLAKLALPAIYAFGAL 138
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
36-164 1.04e-03

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 40.13  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFfsLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIvCTSSVLPKALVGLAfEENTISFPGCMAQLFFL 115
Cdd:cd14987    3 LSFFYIF--IFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADL-CVVATLPVWVVSLV-QHNQWPMGEFTCKITHL 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 297491095 116 TWSAS--SELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVW--ALCA 164
Cdd:cd14987   79 IFSINlfGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWllAFVA 131
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
48-165 1.05e-03

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 40.11  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNA-VIIAVGSHSaSLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLL 126
Cdd:cd15060   13 FTIVGNIlVILSVFTYR-PLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCTASILNL 91
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 297491095 127 TAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15060   92 CAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSAL 130
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
42-168 1.07e-03

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 40.12  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDI--VCTssvLPKALVGLAFEENTISFPG-CMAQLFFLTWS 118
Cdd:cd15193    7 YLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLvfVLT---LPFWAASTALGGQWLFGEGlCKLSSFIIAVN 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 297491095 119 ASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGS 168
Cdd:cd15193   84 RCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGI 133
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
108-165 1.16e-03

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 40.14  E-value: 1.16e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 297491095 108 CMAQLFFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15200   73 CQVNLFMLSMNRTASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILL 130
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
40-165 1.29e-03

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 40.11  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  40 CCFFSLYTVALMGNAVIIAVGSHSASLQSPMY-FFLCNLAAMDIVCTSSVLPKALVGL--------AFEENTISFPgcma 110
Cdd:cd15057    5 CILYLLVLLTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLVAILVMPWAAVNEvagywpfgSFCDVWVSFD---- 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 297491095 111 qlfFLTWSASseLLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15057   81 ---IMCSTAS--ILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSAL 130
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
39-165 1.33e-03

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 39.77  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  39 FCCFFSL-YTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVctssvlpkALVGLAFEENTI-----SFPGCMAQL 112
Cdd:cd15094    3 SAVLYGLiCIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADEC--------FLIGLPFLIVTMilkywPFGAAMCKI 74
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 297491095 113 FFLTWSASS--ELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15094   75 YMVLTSINQftSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFL 129
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
50-321 1.45e-03

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 39.55  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  50 LMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLLTAM 129
Cdd:cd15307   15 AAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIMHLCTI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 130 AYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALcALNGSLHAGLMtrLSFCGPNVIAHFFCEIPPLLLlscspTLVNSIM 209
Cdd:cd15307   95 SVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLL-SIAMSLPLSLM--YSKDHASVLVNGTCQIPDPVY-----KLVGSIV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 210 tvladAFYgvLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVY-----YSAVFCAYISPASSYSPErSKV 284
Cdd:cd15307  167 -----CFY--IPLGVMLLTYCLTVRLLARQRSRHGRIIRLEQKATKVLGVVFFtfvilWSPFFVLNLLPTVCAECE-ERI 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 297491095 285 SAVLYTML------SPTLNPIVYSLRNTEIKHALGRLvqaLLC 321
Cdd:cd15307  239 SHWVFDVVtwlgyaSSMVNPIFYTIFNKVFRQAFKKV---LLC 278
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
48-165 1.54e-03

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 39.61  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSvLPKALVGLAFEENTI-SFPGCMAQLFFLTWSASSELLLL 126
Cdd:cd15168   13 VGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLS-LPFLIYYYANGDHWIfGDFMCKLVRFLFYFNLYGSILFL 91
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 297491095 127 TAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15168   92 TCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLL 130
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
48-165 1.61e-03

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 39.47  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLLT 127
Cdd:cd15324   13 VTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSIVHLC 92
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 297491095 128 AMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15324   93 AISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAV 130
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
36-303 1.97e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 39.24  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTssvlpkaLVGLAFEENTI--------SFPG 107
Cdd:cd15134    1 IPITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLL-------ILGLPFELYTIwqqypwvfGEVF 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 108 CMAQLFFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVW---ALCALNGSLHAGL--MTRLSFCGP 182
Cdd:cd15134   74 CKLRAFLSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWiiaFVCALPFAIQTRIvyLEYPPTSGE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 183 NVIAHFFC-------EIPPLLLLSCSptlvnsimtvladaFYGVLNFLLTLVSYGCIVASILR--------MRSAAGRRR 247
Cdd:cd15134  154 ALEESAFCamlneipPITPVFQLSTF--------------LFFIIPMIAIIVLYVLIGLQLRRstllrrgqRSVSGGRRS 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 297491095 248 AFSTCSshllVVSVYYSAVFCAYISPA--------SSYSPERSK-----------VSAVLYTMlSPTLNPIVYSL 303
Cdd:cd15134  220 SQSRRT----VLRMLVAVVVAFFICWApfhaqrllTVYAKNMTPpylfinrilfyISGVLYYV-SSTVNPILYNV 289
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
41-165 2.59e-03

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 38.80  E-value: 2.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  41 CFFSLYT-VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDI---VC------TSSVLPKALVGLAFeentisfpgCMA 110
Cdd:cd15095    5 LIFAIIFlVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLaflVCcvpftaALYATPSWVFGDFM---------CKF 75
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 297491095 111 QLFFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15095   76 VNYMMQVTVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFL 130
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
45-180 2.67e-03

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 38.98  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  45 LYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSvLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELL 124
Cdd:cd15154   10 LFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLS-LPLRIYYYANHYWPFGNFLCQFSGSIFQMNMYGSCL 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 297491095 125 LLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCaLNGSLHAGLMTRLSFC 180
Cdd:cd15154   89 FLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALI-LGGSVPAAIVHSSSDC 143
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
50-165 2.83e-03

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 38.73  E-value: 2.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  50 LMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLP--KALVGLAFEENTISFPGCMAQLFFLTWSASSELLLLT 127
Cdd:cd15958   15 VAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPfgATLVVRGRWLYGSFFCELWTSVDVLCVTASIETLCVI 94
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 297491095 128 AMayDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15958   95 AI--DRYLAITSPFRYQSLLTRARAKGIVCTVWAISAL 130
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
41-162 2.89e-03

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 38.50  E-value: 2.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  41 CFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFeeNTISFPGCMAQLFfltwsAS 120
Cdd:cd15061    5 FLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLL--GYWPLGSHLCDFW-----IS 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 297491095 121 SELLLLTA-------MAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd15061   78 LDVLLCTAsilnlccISLDRYFAITYPLKYRTKRSRRLAITMILAVWVI 126
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
38-312 2.92e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 38.61  E-value: 2.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFfslytVALMGNAVIIAVGSHSASlQSPMYFFLCNLAAMDIvctssvlpkaLVGLAFEENTI-----SFPGCMAQL 112
Cdd:cd15102    9 AICCF-----IVLENLLVLIAIWRHMKF-HRPMYYFLGNLALSDL----------LAGAAYLANILlsgarTLRLSPAQW 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 113 F------FLTWSASSELLLltAMAYDRYVAICRPLHYSSRMSPRLCrSLAVGVWALCALNGSLHAglmtrlsfCGPNVIA 186
Cdd:cd15102   73 FlregsmFVALSASVFSLL--AIAIERHLTMAKMKPYGASKTSRVL-LLIGACWLISLLLGGLPI--------LGWNCLG 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 187 HffceippllLLSCS---PTLVNSIMTVLADAFYGVLnflLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVSVYY 263
Cdd:cd15102  142 A---------LDACStvlPLYSKHYVLFCVTIFAGIL---AAIVALYARIYCLVRASGRKATRASASPRSLALLKTVLIV 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 297491095 264 SAVFCAYISPASSY----SPERSKVSAVLY--------TMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15102  210 LLVFIACWGPLFILllldVACPVKTCPILYkadwflalAVLNSALNPIIYTLRSRELRRAV 270
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
34-141 3.05e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 38.64  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  34 LRLPLFCCFFSLytvALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLF 113
Cdd:cd15979    2 VRILLYSVIFLL---SVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAY 78
                         90       100
                 ....*....|....*....|....*...
gi 297491095 114 FLTWSASSELLLLTAMAYDRYVAICRPL 141
Cdd:cd15979   79 LMGVSVSVSTFSLVAIAIERYSAICNPL 106
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
36-181 3.21e-03

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 38.60  E-value: 3.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  36 LPLFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVctssVLpkaLVGLAFE--ENTISFP------G 107
Cdd:cd15358    1 TPVCVTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLL----VL---LLGMPLElyEMWSNYPfllgagG 73
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 297491095 108 CMAQLFFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWA---LCAL-NGSLHaGLMTRLSFCG 181
Cdd:cd15358   74 CYFKTLLFETVCFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVvsiLCSIpNTSLH-GIFQLTVPCR 150
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
41-312 3.49e-03

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 38.41  E-value: 3.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  41 CFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKAlVGLAFEENTISFPGCMAQLFFL--TWS 118
Cdd:cd15310    6 SYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWV-VYLEVTGGVWNFSRICCDVFVTldVMM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 119 ASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMTRLSFCG-PNViahffceipplll 197
Cdd:cd15310   85 CTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVSLMITAVWVLAFAVSCPLLFGFNTTGdPTV------------- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 198 lsCSPTLVNSIMTVLADAFYgvLNFLLTLVSYGCIVASILRmrsaagRRRAFSTCSSHLLVVSVYYSAVFCAYI----SP 273
Cdd:cd15310  152 --CSISNPDFVIYSSVVSFY--LPFGVTLLVYVRIYVVLLR------EKKATQMLAIVLGAFIVCWLPFFLTHIlnthCQ 221
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 297491095 274 ASSYSPERSKVSAVLyTMLSPTLNPIVYSLRNTEIKHAL 312
Cdd:cd15310  222 ACHVPPELYSATTWL-GYVNSALNPVIYTTFNIEFRRAF 259
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
45-167 3.98e-03

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 38.40  E-value: 3.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  45 LYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAfeeNTISFPGCMAQLFFLT--WSASSE 122
Cdd:cd15091   10 VFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLM---NSWPFGDVLCKIVISIdyYNMFTS 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 297491095 123 LLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNG 167
Cdd:cd15091   87 IFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVG 131
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
48-167 4.04e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 38.29  E-value: 4.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKAL---VGLAFEentisFPGCMAQLFFLTWSASSELL 124
Cdd:cd15071   13 VSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIiinIGPQTE-----FYSCLMVACPVLILTQSSIL 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 297491095 125 LLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNG 167
Cdd:cd15071   88 ALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVG 130
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
42-165 4.17e-03

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 38.39  E-value: 4.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAV---IIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISF--PGCMAQLFFLT 116
Cdd:cd15130    7 YLALFVVGTVGNSVtlfTLARKKSLQSLQSTVRYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFgdAGCRGYYFLRD 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 297491095 117 WSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15130   87 ACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASAL 135
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
38-166 5.11e-03

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 38.24  E-value: 5.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTV-ALMGN-AVIIAVGSHSaSLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFL 115
Cdd:cd15056    2 VLSTFLSLVILlTILGNlLVIVAVCTDR-QLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 297491095 116 TWSASSELLLLTAMAYDRYVAICR-PLHYssRMSPRLCRSLAVGVWALCALN 166
Cdd:cd15056   81 VLLTTASIMHLCCIALDRYYAICCqPLVY--KMTPLRVAVMLGGCWVIPTFI 130
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
38-165 5.24e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 37.84  E-value: 5.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  38 LFCCFFSLYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTW 117
Cdd:cd15209    3 LACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGL 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 297491095 118 SASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15209   83 SVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVL 130
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
48-160 5.25e-03

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 37.97  E-value: 5.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALvglafeenTISFPGCMA--QLFFLTWSA------ 119
Cdd:cd15327   13 MAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSA--------TLEVLGFWAfgRVFCDIWAAvdvlcc 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 297491095 120 SSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVW 160
Cdd:cd15327   85 TASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLW 125
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
108-165 5.93e-03

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 37.86  E-value: 5.93e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 297491095 108 CMAQLFFLTWSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15374   73 CKIVRFLFYANLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTV 130
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
44-162 6.60e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 37.47  E-value: 6.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  44 SLYTVA-LMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVglafeeNTISFPGCMAQLFFLTWSAS-- 120
Cdd:cd15333   12 ALITLAtTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIV------YTVTGTWTLGQVVCDIWLSSdi 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 297491095 121 ----SELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd15333   86 tcctASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVI 131
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
43-160 6.62e-03

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 37.70  E-value: 6.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  43 FSLYTVAlmGNA-VIIAVGShSASLQSPMYFFLCNLAAMDIVCTSSVLPKALV---------GLAFEENTISFPGCMAql 112
Cdd:cd15051   10 IILLTVI--GNVlVCLAVAV-NRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIyelrgewplGPVFCNIYISLDVMLC-- 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 297491095 113 ffltwsaSSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVW 160
Cdd:cd15051   85 -------TASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIW 125
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
48-165 7.21e-03

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 37.64  E-value: 7.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMD-IVCTSSVLPKALVGLAFEENTISFPgC--MAQLFFLTWSASseLL 124
Cdd:cd15001   12 LGLIGNSLVIFVVARFRRMRSVTNVFLASLATADlLLLVFCVPLKTAEYFSPTWSLGAFL-CkaVAYLQLLSFICS--VL 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 297491095 125 LLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15001   89 TLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAI 129
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
47-141 7.43e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 37.45  E-value: 7.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  47 TVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLL 126
Cdd:cd15075   12 IASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAVAFFGIAALCTV 91
                         90
                 ....*....|....*
gi 297491095 127 TAMAYDRYVAICRPL 141
Cdd:cd15075   92 AVIAVDRLFVVCKPL 106
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
45-162 8.08e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 37.56  E-value: 8.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  45 LYTVALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDI---VCtssvLPKALVGLaFEENTISFPGCMAQLF-FLTWSAS 120
Cdd:cd15131   10 LFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLlifLC----MPLDLYRL-WQYRPWNFGDLLCKLFqFVSESCT 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 297491095 121 -SELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd15131   85 ySTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAV 127
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
48-167 8.30e-03

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 37.24  E-value: 8.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSvLPKALVGLAFEENTISFPGCMAQLFFLTWSASSELLLLT 127
Cdd:cd15089   13 VGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLT 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 297491095 128 AMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNG 167
Cdd:cd15089   92 MMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVG 131
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
48-162 8.38e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 37.62  E-value: 8.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  48 VALMGNAVIIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEEN-TISFPGCMAQLFFLTWSASSELLLL 126
Cdd:cd15217   13 VSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAwTYSVLSCKIVAFMAVLFCFHAAFML 92
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 297491095 127 TAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWAL 162
Cdd:cd15217   93 FCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTL 128
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
47-260 9.70e-03

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 37.10  E-value: 9.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  47 TVALMGNAVIIAVGSHSASL--QSPMYFFLCNLAAMDIVcTSSVLPKALVGLAFEENTI-SFPGCMAQLFFLTWSASSEL 123
Cdd:cd14976   12 TVGLLGNLLVLYLLKSNKKLrqQSESNKFVFNLALTDLI-FVLTLPFWAVEYALDFVWPfGTAMCKVVRYVTKLNMYSSI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095 124 LLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCALNGSLHAGLMT-RLSFCGPNVIAHFFceipPLLLLSCSP 202
Cdd:cd14976   91 FFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFSTdTWSSVNHTLCLLRF----PKNSSVTRW 166
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 297491095 203 TLVNSIMTVLADAFYGVLNFLLTLVSYGCIVASILRMRSAAGRRRAFSTCSSHLLVVS 260
Cdd:cd14976  167 YNWLGMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGGSKRRKSRVTKSVFIVVLS 224
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
42-165 9.99e-03

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 37.13  E-value: 9.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297491095  42 FFSLYTVALMGNAV---IIAVGSHSASLQSPMYFFLCNLAAMDIVCTSSVLPKALVGLAFEENTISF--PGCMAQLFFLT 116
Cdd:cd15355    7 YLALFVVGTVGNSItlyTLARKKSLQHLQSTVHYHLASLALSDLLILLLAMPVELYNFIWVHHPWAFgdAACRGYYFLRD 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 297491095 117 WSASSELLLLTAMAYDRYVAICRPLHYSSRMSPRLCRSLAVGVWALCAL 165
Cdd:cd15355   87 ACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASAL 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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