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Conserved domains on  [gi|392355279|ref|XP_002728982|]
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pericentrin isoform X17 [Rattus norvegicus]

Protein Classification

ClyA-like and PACT_coil_coil domain-containing protein( domain architecture ID 13380129)

protein containing domains Smc, SMC_prok_B, ClyA-like, and PACT_coil_coil

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PACT_coil_coil pfam10495
Pericentrin-AKAP-450 domain of centrosomal targeting protein; This domain is a coiled-coil ...
 2647-2725 7.33e-27

Pericentrin-AKAP-450 domain of centrosomal targeting protein; This domain is a coiled-coil region close to the C-terminus of centrosomal proteins that is directly responsible for recruiting AKAP-450 and pericentrin to the centrosome. Hence the suggested name for this region is a PACT domain (pericentrin-AKAP-450 centrosomal targeting). This domain is also present at the C-terminus of coiled-coil proteins from Drosophila and S. pombe, and that from the Drosophila protein is sufficient for targeting to the centrosome in mammalian cells. The function of these proteins is unknown but they seem good candidates for having a centrosomal or spindle pole body location. The final 22 residues of this domain in AKAP-450 appear specifically to be a calmodulin-binding domain indicating that this member at least is likely to contribute to centrosome assembly.


:

Pssm-ID: 463115  Cd Length: 77  Bit Score: 105.75  E-value: 7.33e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392355279  2647 YLRAESFRKALIYQKKYLLLLIGGFQDSEQETLSMIAHLGVFPSKADKKvtaSRPFTRFRTAVRVVIAVLRLRFLVKKW 2725
Cdd:pfam10495    2 LLREESFRKDLAYQKKYLLLLLGGYQACNKADLRLLAQMGVTPPDDRPS---RKPRRKLKSAALAVIAIARMKRLAREW 77
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 462-1422 6.74e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 78.17  E-value: 6.74e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   462 LDLQLEQPKAQGSLIEDYQEkLSNAEEKIE--LMKQEFQKKEAEWELSREDLKRDAEEKLAsmfLELREKAESEKLSIIN 539
Cdd:TIGR02168  198 LERQLKSLERQAEKAERYKE-LKAELRELElaLLVLRLEELREELEELQEELKEAEEELEE---LTAELQELEEKLEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   540 -RFELRESSMRHLQD---QQAAQISDLERSLREQQGHLRQLEQELTRDEvllcsqcgkepsvAQDEKsailLREKEDCAL 615
Cdd:TIGR02168  274 lEVSELEEEIEELQKelyALANEISRLEQQKQILRERLANLERQLEELE-------------AQLEE----LESKLDELA 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   616 QLLTAQNRFLEERKEIMEKFAKEQDAFLLDTQEKHSHELQLLQQGHQQQLLALRMELETKhhsELTEQLASLESKQQALl 695
Cdd:TIGR02168  337 EELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIA---SLNNEIERLEARLERL- 412

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   696 ethvAKMQVKHDAEISALEKrhlsnldELESCYVADIQTIRDEHKKALELLRAELEEQLQKKDSCHREILTQELEKLKLK 775
Cdd:TIGR02168  413 ----EDRRERLQQEIEELLK-------KLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAE 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   776 HAEELQSVRNSLRVKMSAQHTESGKGPAADLQGAHQKAPAMALHNEGHQLEEDGDAALGGADTEDLQHhaepreregpht 855
Cdd:TIGR02168  482 RELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGRLQA------------ 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   856 VEMQTSQTELakpqELQASQDQGAQVRDQVFLLSReleeCRGELEQLQQRRERENQEGATLICMLRADVDlaqsegKALR 935
Cdd:TIGR02168  550 VVVENLNAAK----KAIAFLKQNELGRVTFLPLDS----IKGTEIQGNDREILKNIEGFLGVAKDLVKFD------PKLR 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   936 DALRRLLD--LFGETLKAAVTLKSRISERAGLLLdhedavdtsgaqlaaaalgemwpdeglLDIDRTLPEGAETSSVCEI 1013
Cdd:TIGR02168  616 KALSYLLGgvLVVDDLDNALELAKKLRPGYRIVT---------------------------LDGDLVRPGGVITGGSAKT 668

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1014 SShvcesffmspeNTQECEQPIRKvyqsLSTAVEGLLDMALDSSKQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLE 1093
Cdd:TIGR02168  669 NS-----------SILERRREIEE----LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRK 733

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1094 RLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEE----NSVLW 1169
Cdd:TIGR02168  734 DLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAldelRAELT 813

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1170 NQKETFTNeAKEREAALQKEVESLTRDQWESRKQSEKDRATLLSqmrvLESELEDQLVQhrgCAQLAEEVTTLKQQLATL 1249
Cdd:TIGR02168  814 LLNEEAAN-LRERLESLERRIAATERRLEDLEEQIEELSEDIES----LAAEIEELEEL---IEELESELEALLNERASL 885

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1250 DKHLRSQRQFMDEqaaerehereeFQQEIKWLEGQLRQATRPRppGPRDSQCAKLDEEVELLQEKLREKLDGFNELVIkk 1329
Cdd:TIGR02168  886 EEALALLRSELEE-----------LSEELRELESKRSELRREL--EELREKLAQLELRLEGLEVRIDNLQERLSEEYS-- 950

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1330 dladqqllIQEEEIKHLEETNENiqrQMAQLQEELEKQRRSTEELEVVNSRN-SEIEELKAIIEHLQENQEQLQKAKaee 1408
Cdd:TIGR02168  951 --------LTLEEAEALENKIED---DEEEARRRLKRLENKIKELGPVNLAAiEEYEELKERYDFLTAQKEDLTEAK--- 1016

                          970
                   ....*....|....
gi 392355279  1409 iEQLHEVIEKLQSE 1422
Cdd:TIGR02168 1017 -ETLEEAIEEIDRE 1029
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 120-587 5.35e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 75.36  E-value: 5.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  120 LELEALRLSLNNMHTAQLELTQANLQKEKETALTELREMLNGRRAQELALLQSRQQCELELMREQHAREKEEmaLRNEQE 199
Cdd:COG1196   274 LELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE--LEEAEE 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  200 TAELKEKFRSEMEKTVQMMETLKQDWESERELCLETLRKELSAkhQSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEVS 279
Cdd:COG1196   352 ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA--AAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  280 LKNLEAQHQAAIRKLQEDLRSEhcQYLQDLELRFREKEKAKELELETLQASYEDLKAQSQEEIRHLWSQLEsMKTNREEQ 359
Cdd:COG1196   430 LAELEEEEEEEEEALEEAAEEE--AELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLE-AEADYEGF 506

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  360 NGSWEPLLAQASHLEELQHLRSDFAQQQQQERAQHESELEHLRVYFEKKLNDAEKtyqedLTVFQQRLQEAREESLESAE 439
Cdd:COG1196   507 LEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAA-----AIEYLKAAKAGRATFLPLDK 581

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  440 ISSSCMFPEETSGRERKEPPDPLDLQLEQPKAQGSLIEDYQEKLSNAEEKIELMKQEFQKKEAEWELSREDlkRDAEEKL 519
Cdd:COG1196   582 IRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLE--GEGGSAG 659

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392355279  520 ASMFLELREKAESEKLSIINRFELRESSMRHLQDQQAAQISDLERSLREQQGHLRQLEQELTRDEVLL 587
Cdd:COG1196   660 GSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALE 727
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2104-2404 7.91e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.04  E-value: 7.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2104 LLAEIQALRAQLRMTHLqnqEKLQQLCAALTSTEARGSQREHQLRRQVELLAYKVEQEKCIANDLQKTLSKEQEAASDVR 2183
Cdd:COG1196   218 LKEELKELEAELLLLKL---RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELL 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2184 KRLMVEQGAVQDLKSELHACKQENTNLLESLDKVQQEVLRLRAVLDGKENELKVVLEELEcergkgqVLQAQQEEQQLRH 2263
Cdd:COG1196   295 AELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE-------EAEAELAEAEEAL 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2264 LQREGQSSRALEELKISLEKQLAQNNQLCVALKHERaakdNLQKELQIEASRCEALLAQEKGQLSELRKSLEAERSRSLE 2343
Cdd:COG1196   368 LEAEAELAEAEEELEELAEELLEALRAAAELAAQLE----ELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEA 443

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392355279 2344 LSEALQ-HERLLTEQLSRNAQEACARQDTQAQHALLRKLKAEKARALELEAMLEKVQKQAAH 2404
Cdd:COG1196   444 LEEAAEeEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEG 505
EnvC super family cl34844
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1328-1550 3.41e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG4942:

Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 3.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1328 KKDLADQQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELE-VVNSRNSEIEELKAIIEHLQENQEQLQKAKA 1406
Cdd:COG4942    21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALArRIRALEQELAALEAELAELEKEIAELRAELE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1407 EEIEQLHEVIEKLQselsLMGPTVHEMSDLPPGSLHTELSCLQAEGMGGQALHNELQAAQAAKGAFGQLladhghSQALE 1486
Cdd:COG4942   101 AQKEELAELLRALY----RLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAAL------RAELE 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392355279 1487 ALQERLQDAEAAAARHLTELEHCVALRQAEVEAMASRIQEFEATLKAKEAIIVQRDLEIDAVNK 1550
Cdd:COG4942   171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEA 234
 
Name Accession Description Interval E-value
PACT_coil_coil pfam10495
Pericentrin-AKAP-450 domain of centrosomal targeting protein; This domain is a coiled-coil ...
 2647-2725 7.33e-27

Pericentrin-AKAP-450 domain of centrosomal targeting protein; This domain is a coiled-coil region close to the C-terminus of centrosomal proteins that is directly responsible for recruiting AKAP-450 and pericentrin to the centrosome. Hence the suggested name for this region is a PACT domain (pericentrin-AKAP-450 centrosomal targeting). This domain is also present at the C-terminus of coiled-coil proteins from Drosophila and S. pombe, and that from the Drosophila protein is sufficient for targeting to the centrosome in mammalian cells. The function of these proteins is unknown but they seem good candidates for having a centrosomal or spindle pole body location. The final 22 residues of this domain in AKAP-450 appear specifically to be a calmodulin-binding domain indicating that this member at least is likely to contribute to centrosome assembly.


Pssm-ID: 463115  Cd Length: 77  Bit Score: 105.75  E-value: 7.33e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392355279  2647 YLRAESFRKALIYQKKYLLLLIGGFQDSEQETLSMIAHLGVFPSKADKKvtaSRPFTRFRTAVRVVIAVLRLRFLVKKW 2725
Cdd:pfam10495    2 LLREESFRKDLAYQKKYLLLLLGGYQACNKADLRLLAQMGVTPPDDRPS---RKPRRKLKSAALAVIAIARMKRLAREW 77
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 462-1422 6.74e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 78.17  E-value: 6.74e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   462 LDLQLEQPKAQGSLIEDYQEkLSNAEEKIE--LMKQEFQKKEAEWELSREDLKRDAEEKLAsmfLELREKAESEKLSIIN 539
Cdd:TIGR02168  198 LERQLKSLERQAEKAERYKE-LKAELRELElaLLVLRLEELREELEELQEELKEAEEELEE---LTAELQELEEKLEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   540 -RFELRESSMRHLQD---QQAAQISDLERSLREQQGHLRQLEQELTRDEvllcsqcgkepsvAQDEKsailLREKEDCAL 615
Cdd:TIGR02168  274 lEVSELEEEIEELQKelyALANEISRLEQQKQILRERLANLERQLEELE-------------AQLEE----LESKLDELA 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   616 QLLTAQNRFLEERKEIMEKFAKEQDAFLLDTQEKHSHELQLLQQGHQQQLLALRMELETKhhsELTEQLASLESKQQALl 695
Cdd:TIGR02168  337 EELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIA---SLNNEIERLEARLERL- 412

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   696 ethvAKMQVKHDAEISALEKrhlsnldELESCYVADIQTIRDEHKKALELLRAELEEQLQKKDSCHREILTQELEKLKLK 775
Cdd:TIGR02168  413 ----EDRRERLQQEIEELLK-------KLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAE 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   776 HAEELQSVRNSLRVKMSAQHTESGKGPAADLQGAHQKAPAMALHNEGHQLEEDGDAALGGADTEDLQHhaepreregpht 855
Cdd:TIGR02168  482 RELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGRLQA------------ 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   856 VEMQTSQTELakpqELQASQDQGAQVRDQVFLLSReleeCRGELEQLQQRRERENQEGATLICMLRADVDlaqsegKALR 935
Cdd:TIGR02168  550 VVVENLNAAK----KAIAFLKQNELGRVTFLPLDS----IKGTEIQGNDREILKNIEGFLGVAKDLVKFD------PKLR 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   936 DALRRLLD--LFGETLKAAVTLKSRISERAGLLLdhedavdtsgaqlaaaalgemwpdeglLDIDRTLPEGAETSSVCEI 1013
Cdd:TIGR02168  616 KALSYLLGgvLVVDDLDNALELAKKLRPGYRIVT---------------------------LDGDLVRPGGVITGGSAKT 668

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1014 SShvcesffmspeNTQECEQPIRKvyqsLSTAVEGLLDMALDSSKQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLE 1093
Cdd:TIGR02168  669 NS-----------SILERRREIEE----LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRK 733

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1094 RLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEE----NSVLW 1169
Cdd:TIGR02168  734 DLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAldelRAELT 813

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1170 NQKETFTNeAKEREAALQKEVESLTRDQWESRKQSEKDRATLLSqmrvLESELEDQLVQhrgCAQLAEEVTTLKQQLATL 1249
Cdd:TIGR02168  814 LLNEEAAN-LRERLESLERRIAATERRLEDLEEQIEELSEDIES----LAAEIEELEEL---IEELESELEALLNERASL 885

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1250 DKHLRSQRQFMDEqaaerehereeFQQEIKWLEGQLRQATRPRppGPRDSQCAKLDEEVELLQEKLREKLDGFNELVIkk 1329
Cdd:TIGR02168  886 EEALALLRSELEE-----------LSEELRELESKRSELRREL--EELREKLAQLELRLEGLEVRIDNLQERLSEEYS-- 950

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1330 dladqqllIQEEEIKHLEETNENiqrQMAQLQEELEKQRRSTEELEVVNSRN-SEIEELKAIIEHLQENQEQLQKAKaee 1408
Cdd:TIGR02168  951 --------LTLEEAEALENKIED---DEEEARRRLKRLENKIKELGPVNLAAiEEYEELKERYDFLTAQKEDLTEAK--- 1016

                          970
                   ....*....|....
gi 392355279  1409 iEQLHEVIEKLQSE 1422
Cdd:TIGR02168 1017 -ETLEEAIEEIDRE 1029
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 120-587 5.35e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 75.36  E-value: 5.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  120 LELEALRLSLNNMHTAQLELTQANLQKEKETALTELREMLNGRRAQELALLQSRQQCELELMREQHAREKEEmaLRNEQE 199
Cdd:COG1196   274 LELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE--LEEAEE 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  200 TAELKEKFRSEMEKTVQMMETLKQDWESERELCLETLRKELSAkhQSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEVS 279
Cdd:COG1196   352 ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA--AAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  280 LKNLEAQHQAAIRKLQEDLRSEhcQYLQDLELRFREKEKAKELELETLQASYEDLKAQSQEEIRHLWSQLEsMKTNREEQ 359
Cdd:COG1196   430 LAELEEEEEEEEEALEEAAEEE--AELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLE-AEADYEGF 506

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  360 NGSWEPLLAQASHLEELQHLRSDFAQQQQQERAQHESELEHLRVYFEKKLNDAEKtyqedLTVFQQRLQEAREESLESAE 439
Cdd:COG1196   507 LEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAA-----AIEYLKAAKAGRATFLPLDK 581

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  440 ISSSCMFPEETSGRERKEPPDPLDLQLEQPKAQGSLIEDYQEKLSNAEEKIELMKQEFQKKEAEWELSREDlkRDAEEKL 519
Cdd:COG1196   582 IRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLE--GEGGSAG 659

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392355279  520 ASMFLELREKAESEKLSIINRFELRESSMRHLQDQQAAQISDLERSLREQQGHLRQLEQELTRDEVLL 587
Cdd:COG1196   660 GSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALE 727
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2104-2404 7.91e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.04  E-value: 7.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2104 LLAEIQALRAQLRMTHLqnqEKLQQLCAALTSTEARGSQREHQLRRQVELLAYKVEQEKCIANDLQKTLSKEQEAASDVR 2183
Cdd:COG1196   218 LKEELKELEAELLLLKL---RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELL 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2184 KRLMVEQGAVQDLKSELHACKQENTNLLESLDKVQQEVLRLRAVLDGKENELKVVLEELEcergkgqVLQAQQEEQQLRH 2263
Cdd:COG1196   295 AELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE-------EAEAELAEAEEAL 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2264 LQREGQSSRALEELKISLEKQLAQNNQLCVALKHERaakdNLQKELQIEASRCEALLAQEKGQLSELRKSLEAERSRSLE 2343
Cdd:COG1196   368 LEAEAELAEAEEELEELAEELLEALRAAAELAAQLE----ELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEA 443

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392355279 2344 LSEALQ-HERLLTEQLSRNAQEACARQDTQAQHALLRKLKAEKARALELEAMLEKVQKQAAH 2404
Cdd:COG1196   444 LEEAAEeEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEG 505
PTZ00121 PTZ00121
MAEBL; Provisional
 154-779 3.77e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 66.32  E-value: 3.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  154 ELREMLNGRRAQELALLQSRQQCElELMREQHAREKEEMalRNEQETAELKEKFRSEMEKTVQMMETLKQDWESERELCL 233
Cdd:PTZ00121 1138 DARKAEEARKAEDAKRVEIARKAE-DARKAEEARKAEDA--KKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKA 1214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  234 ETLRKELSAKHQSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEVSLKNLEAQHQAAI-----RKLQEDLRSEHCQYLQD 308
Cdd:PTZ00121 1215 EEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIkaeeaRKADELKKAEEKKKADE 1294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  309 LElRFREKEKAKELELETLQASYEDLKAQSQEEIRhlwSQLESMKTNREEQNGSWEPLLAQAShleelqhlrsdfAQQQQ 388
Cdd:PTZ00121 1295 AK-KAEEKKKADEAKKKAEEAKKADEAKKKAEEAK---KKADAAKKKAEEAKKAAEAAKAEAE------------AAADE 1358

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  389 QERAQHESELEHLRVYFEKKLNDAEKTYQEDLTVFQQRLQEAREESLESAEISSScmfpeetsgRERKEPPDPLDLQLEQ 468
Cdd:PTZ00121 1359 AEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKA---------AAAKKKADEAKKKAEE 1429

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  469 PKAQGSLIEDYQEKLSNAEEKI---ELMKQEFQKKEAEWELSREDLKRDAEEKLASMflELREKAES--EKLSIINRFEL 543
Cdd:PTZ00121 1430 KKKADEAKKKAEEAKKADEAKKkaeEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAD--EAKKKAEEakKKADEAKKAAE 1507

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  544 RESSMRHLQDQQAAQISDLERSLREQQG--HLRQLEQELTRDEVLLCSQCGKEPSVAQDEKSAillREKEDCALQLLTAQ 621
Cdd:PTZ00121 1508 AKKKADEAKKAEEAKKADEAKKAEEAKKadEAKKAEEKKKADELKKAEELKKAEEKKKAEEAK---KAEEDKNMALRKAE 1584

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  622 NRFLEERKEIMEKFAKEQDAFLLDTQEKHSHELQLLQQGHQQQLLALRMELETKHHSElTEQLASLESKQQALLETHVAK 701
Cdd:PTZ00121 1585 EAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKE-AEEKKKAEELKKAEEENKIKA 1663

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  702 MQVKHDAEISALEKRHLSNLDElESCYVADIQTIRDEHKKALELLRAELEEQLQKKDSCHR--EILTQELEKLKLKHAEE 779
Cdd:PTZ00121 1664 AEEAKKAEEDKKKAEEAKKAEE-DEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKaeEENKIKAEEAKKEAEED 1742
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1058-1545 9.17e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.57  E-value: 9.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1058 KQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEESE 1137
Cdd:COG1196   239 AELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERL 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1138 QQLIVELEDLRKQLQQASRELLTLKEENSVLWNQKETFTNEAKEREAALQKEVESLTRDQwESRKQSEKDRATLLSQMRV 1217
Cdd:COG1196   319 EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE-EELEELAEELLEALRAAAE 397

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1218 LESELEDQLVQHRGCAQLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQATRprppgpr 1297
Cdd:COG1196   398 LAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLE------- 470

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1298 dsQCAKLDEEVELLQEKLREKLDgfNELVIKKDLADQQLLIQEEEIKHLEETNENIQRQMAQLQ---EELEKQRRSTEEL 1374
Cdd:COG1196   471 --EAALLEAALAELLEELAEAAA--RLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIgveAAYEAALEAALAA 546

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1375 EVVNSRNSEIEELKAIIEHLQENQ---------EQLQKAKAEEIEQLHEVIEKLQSELSLMGPTVHEMSDLPPGSLHTEL 1445
Cdd:COG1196   547 ALQNIVVEDDEVAAAAIEYLKAAKagratflplDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRT 626

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1446 SCLQAEGMGGQAL------HNELQAAQAAKGAFGQLLADHGHSQALEALQERLQDAEAAAARHLTELEHCVALRQAEVEA 1519
Cdd:COG1196   627 LVAARLEAALRRAvtlagrLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEE 706

                         490       500
                  ....*....|....*....|....*.
gi 392355279 1520 MASRIQEFEATLKAKEAIIVQRDLEI 1545
Cdd:COG1196   707 RELAEAEEERLEEELEEEALEEQLEA 732
PTZ00121 PTZ00121
MAEBL; Provisional
 135-648 2.47e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 63.62  E-value: 2.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  135 AQLELTQANLQKEKETALTELREMLNGRRAQELALLQSRQQCELELMREQHAREKEEMALRNEQ---ETAELKEKF---- 207
Cdd:PTZ00121 1263 AHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEakkKADAAKKKAeeak 1342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  208 ------RSEMEKTVQMMETLKQDWESERELCLETLRKELSAKHQSEMEGLQNQFQKELSEQK----------AELEKIFQ 271
Cdd:PTZ00121 1343 kaaeaaKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKkkadelkkaaAAKKKADE 1422

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  272 AKHEAEVSLKNLEAQHQAAIRKLQEDLR--SEHCQYLQDLELRFREKEKAKELELETLQASYEDLKAQSQEEIRHLWSQL 349
Cdd:PTZ00121 1423 AKKKAEEKKKADEAKKKAEEAKKADEAKkkAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEA 1502

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  350 ---ESMKTNREEQNGSWEPLLAQASHLEELQHLRSDFAQQQQQERAQHESELEHLRVYFEKKLNDAEKTYQEDLTVFQQR 426
Cdd:PTZ00121 1503 kkaAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRK 1582

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  427 LQEAREESLESAEISSSCMFPEETSGRERKEPPDPLDLQLEQ-PKAQGSLIEDYQEKLSNAEEKIElmKQEFQKKEAEWE 505
Cdd:PTZ00121 1583 AEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEElKKAEEEKKKVEQLKKKEAEEKKK--AEELKKAEEENK 1660

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  506 LSREDLKR-DAEEKLASMFLELREKAESEKLSIINRFELRESSMRHLQDQQAAQISDLERSLREQQGHLRQLEQELTRDE 584
Cdd:PTZ00121 1661 IKAAEEAKkAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAE 1740

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392355279  585 VLlcSQCGKEPSVAQDEKSAI--LLREKEDCALQLLTAQNRFLEER-KEIMEKFAKEQDAFLLDTQE 648
Cdd:PTZ00121 1741 ED--KKKAEEAKKDEEEKKKIahLKKEEEKKAEEIRKEKEAVIEEElDEEDEKRRMEVDKKIKDIFD 1805
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 136-543 2.06e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 56.99  E-value: 2.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   136 QLELTQANLQKeKETALTELREMLNGRRAQELALLQSRqqcelELMREQHAREKEEMALRNEQETAELkEKFRSEMEKTV 215
Cdd:TIGR02168  180 KLERTRENLDR-LEDILNELERQLKSLERQAEKAERYK-----ELKAELRELELALLVLRLEELREEL-EELQEELKEAE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   216 QMMETLkQDWESERELCLETLRKElsakhQSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEVSLKNLEAQHQAAIRKLQ 295
Cdd:TIGR02168  253 EELEEL-TAELQELEEKLEELRLE-----VSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLE 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   296 EDLRSEHCQylqdlelrfREKEKAKELELETLQASYEDLKAQSQEEIRhlwsQLESMKTNREEQNgswepllaqashlEE 375
Cdd:TIGR02168  327 ELESKLDEL---------AEELAELEEKLEELKEELESLEAELEELEA----ELEELESRLEELE-------------EQ 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   376 LQHLRSDFAqQQQQERAQHESELEHLrvyfEKKLNDAEKTYQEdltvfQQRLQEAREESLESAEIssscmfpeetsgrer 455
Cdd:TIGR02168  381 LETLRSKVA-QLELQIASLNNEIERL----EARLERLEDRRER-----LQQEIEELLKKLEEAEL--------------- 435

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   456 keppDPLDLQLEQPKAQgslIEDYQEKLSNAEEKIELMKQEFQKKEAEWELSREDLKRDAEEK--LASMFLELREKAESE 533
Cdd:TIGR02168  436 ----KELQAELEELEEE---LEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLdsLERLQENLEGFSEGV 508

                          410
                   ....*....|
gi 392355279   534 KLSIINRFEL 543
Cdd:TIGR02168  509 KALLKNQSGL 518
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2169-2455 4.33e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.83  E-value: 4.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2169 QKTLSKEQEAAsDVRKRLMVEQGAVQDLKSELHACKQENTNLLESLDKVQQEVLRLRAVLDGKENELKVVLEELEcergk 2248
Cdd:TIGR02168  670 SSILERRREIE-ELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE----- 743

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2249 gqvlqaqqeeqqlRHLQREGQSSRALEELKISLEKQLAQNNQLCVALKherAAKDNLQKElqieasrcEALLAQEKGQLS 2328
Cdd:TIGR02168  744 -------------QLEERIAQLSKELTELEAEIEELEERLEEAEEELA---EAEAEIEEL--------EAQIEQLKEELK 799

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2329 ELRKSLEAERSRSLELSEALQHERLLTEQLSRNAQEACAR-QDTQAQHALLRKLKAEKARALE-LEAMLEKVQKQAAHtq 2406
Cdd:TIGR02168  800 ALREALDELRAELTLLNEEAANLRERLESLERRIAATERRlEDLEEQIEELSEDIESLAAEIEeLEELIEELESELEA-- 877

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 392355279  2407 QQLEAQAQERCLELRREKERELELQRQRDEHKIEQLQRLVRELRWKEEA 2455
Cdd:TIGR02168  878 LLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQ 926
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 119-579 9.21e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 54.84  E-value: 9.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   119 SLELEALRLSLNNMHTAQLELTQANLQKEKETALTELREMLNGRRAQeLALLQSRQQCELELMREQHAREKEEMALRNEQ 198
Cdd:pfam12128  252 TLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQ-WKEKRDELNGELSAADAAVAKDRSELEALEDQ 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   199 ETAELKEkfrsEMEKTVQMMETLKQdWESERELcLETLRKELSAKHQSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEV 278
Cdd:pfam12128  331 HGAFLDA----DIETAAADQEQLPS-WQSELEN-LEERLKALTGKHQDVTAKYNRRRSKIKEQNNRDIAGIKDKLAKIRE 404

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   279 SLKNLEAQHQAAIRKLQEDLRSEHCQYLQDL-ELRFREKEKAKELELETLQASY-EDLK---AQSQEEIRHLWSQLESMK 353
Cdd:pfam12128  405 ARDRQLAVAEDDLQALESELREQLEAGKLEFnEEEYRLKSRLGELKLRLNQATAtPELLlqlENFDERIERAREEQEAAN 484

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   354 TNREeqngSWEPLLAQASHLEELQHLRSDFAQQQQQERAQHESELEHLrvyfekkLNDAEKTYQEDLTVFQQRLQEAREE 433
Cdd:pfam12128  485 AEVE----RLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQ-------LFPQAGTLLHFLRKEAPDWEQSIGK 553

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   434 SLESAEISSSCMFPEETSGR--------------ERKEPPDPLDL--QLEQPKAQ-GSLIEDYQEKLSNAEEKIELMKQE 496
Cdd:pfam12128  554 VISPELLHRTDLDPEVWDGSvggelnlygvkldlKRIDVPEWAASeeELRERLDKaEEALQSAREKQAAAEEQLVQANGE 633

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   497 FQKKEAEWELSREDLKrDAEEKLASMFLELREKAESEKLSIINRFELRESSMRHLQDQQAAQISDLERSLREQQGHLRQL 576
Cdd:pfam12128  634 LEKASREETFARTALK-NARLDLRRLFDEKQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREA 712


                   ...
gi 392355279   577 EQE 579
Cdd:pfam12128  713 RTE 715
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 486-1420 9.78e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 51.51  E-value: 9.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   486 AEEKIELMKQEFQKKEAEwELSREDLKRDAEEKLasmfLELREKAESEKLSIINRFELRESSMRHLQDQQAA----QISD 561
Cdd:pfam02463  143 KIEIIAMMKPERRLEIEE-EAAGSRLKRKKKEAL----KKLIEETENLAELIIDLEELKLQELKLKEQAKKAleyyQLKE 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   562 LERSLREQQGHLRQLEQELTRDEVLLcsqcGKEPSVAQDEKSAILLREKEDCALQLLTAQNRFLEERKEIMEKFAKEQDA 641
Cdd:pfam02463  218 KLELEEEYLLYLDYLKLNEERIDLLQ----ELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAK 293

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   642 FLldtQEKHSHELQLLQQGHQQQLLALRMELETKHHSELTEQLASLESKQQALLETHVAKMQVKHDAEISALEKRHLSNL 721
Cdd:pfam02463  294 EE---EELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   722 DELESCYVADIQTIRDEHKKALELLRAELEEQLQKKDSCHREILTQELEKLKLKHAEELQSVRNSLRVKMSAQhtesgkg 801
Cdd:pfam02463  371 LEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQ------- 443

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   802 paadlqgahqkapamaLHNEGHQLEEDGDAALGGADTEDLQHHAEPREREGPHTVEMQTSQTELAKPQELQASQDQGAQV 881
Cdd:pfam02463  444 ----------------GKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARS 507

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   882 RDQVFLLSRELEEcrGELEQLQQRRERENQEGATLICMLRADVDLAQSEGKALRDALRRLLDLFGETLKAAVTLKSRISE 961
Cdd:pfam02463  508 GLKVLLALIKDGV--GGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIP 585

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   962 RAGLLLDHeDAVDTSGAQLAAAALGEMWPDEGLLDIDRTLPEGAEtSSVCEISSHVCESFFMSPENTQECEQPIRKVYQS 1041
Cdd:pfam02463  586 KLKLPLKS-IAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGIL-KDTELTKLKESAKAKESGLRKGVSLEEGLAEKSE 663

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1042 LSTAVEGLLDMALDSSKQLEDARQLHRcvEKEFRHRDEEMAQAVQKQQELLERLREESAAKD--RLALELHTAEGLLEGF 1119
Cdd:pfam02463  664 VKASLSELTKELLEIQELQEKAESELA--KEEILRRQLEIKKKEQREKEELKKLKLEAEELLadRVQEAQDKINEELKLL 741

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1120 KVEKAD-LQEALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEENSVLWNQKETFTNEAKEREAALQKEVESLTRDQW 1198
Cdd:pfam02463  742 KQKIDEeEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQ 821

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1199 ESRKQSEKDRATLLSQMRVLESELEDQLVQHRGCAQLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEI 1278
Cdd:pfam02463  822 LLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKE 901

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1279 KWLEGQlrqatrprppgpRDSQCAKLDEEVELLQEKLREKLDGFNELviKKDLADQQLLIQEEEIKHLEETNENIQRQMA 1358
Cdd:pfam02463  902 LEEESQ------------KLNLLEEKENEIEERIKEEAEILLKYEEE--PEELLLEEADEKEKEENNKEEEEERNKRLLL 967

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392355279  1359 QLQEELEKQRRSTEELEVVNSRNSEIEElkaiiehlqenqeQLQKAKAEEIEQLHEVIEKLQ 1420
Cdd:pfam02463  968 AKEELGKVNLMAIEEFEEKEERYNKDEL-------------EKERLEEEKKKLIRAIIEETC 1016
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 2077-2450 1.40e-05

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 50.91  E-value: 1.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2077 KKLEKVIQEQGDLQKVREHACLPDRSSLLAEIQALRAQLRMTHLQNQEKLQQL---CAALTSTEARGSQREHQLRRQVEL 2153
Cdd:pfam07111  284 EELTRKIQPSDSLEPEFPKKCRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLrgqVAELQEQVTSQSQEQAILQRALQD 363

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2154 LAYKVEQEKCIANDLQKTLSKEQEAAsdvRKRLMVEQGAVQDLKSELHACKQENTNLLESLDKVQQEVLRLRAVldgkEN 2233
Cdd:pfam07111  364 KAAEVEVERMSAKGLQMELSRAQEAR---RRQQQQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSL----SN 436

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2234 ELKVVLEELECERGkgqvlqaqqEEQQLRHLQREGQSSRALEELKISLEKQLAqnnqlcVALKHERAAKDNLQKELQI-- 2311
Cdd:pfam07111  437 RLSYAVRKVHTIKG---------LMARKVALAQLRQESCPPPPPAPPVDADLS------LELEQLREERNRLDAELQLsa 501

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2312 -----EASRCEALLAQEKGQLSELRKSLEAERSRS--------LELSEALQHERLLTEQLSRNAQEACARQDTQAQhALL 2378
Cdd:pfam07111  502 hliqqEVGRAREQGEAERQQLSEVAQQLEQELQRAqeslasvgQQLEVARQGQQESTEEAASLRQELTQQQEIYGQ-ALQ 580

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392355279  2379 RKLKAEKARALELEAMLEKVQKQAAHTQQQLEAQAQERCLELRREKERELELQRQRDEHKIEQLQRLVRELR 2450
Cdd:pfam07111  581 EKVAEVETRLREQLSDTKRRLNEARREQAKAVVSLRQIQHRATQEKERNQELRRLQDEARKEEGQRLARRVQ 652
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 234-534 3.28e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 49.63  E-value: 3.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  234 ETLRKELSAKHQSEMEGLQNQFQKELSEQKaelekifqaKHEAEVSLKNLEAQHQAAIRKlQEDLRSEHCQYLQDLELRF 313
Cdd:NF033838  109 EKSEAELTSKTKKELDAAFEQFKKDTLEPG---------KKVAEATKKVEEAEKKAKDQK-EEDRRNYPTNTYKTLELEI 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  314 REKE-KAKELELETLQAsyEDLKAQSQEEIRHLWSQLESMKtnreeqngswepllAQASHLEELQHLRsdfaqqqqqERA 392
Cdd:NF033838  179 AESDvEVKKAELELVKE--EAKEPRDEEKIKQAKAKVESKK--------------AEATRLEKIKTDR---------EKA 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  393 QHESEL---EHLRVYFEKKLNDAEKTYQEDLTVFQQRLQEAREESLESAEISSSCMFPEETsgrerkePPDPlDLQLEQP 469
Cdd:NF033838  234 EEEAKRradAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSVGEET-------LPSP-SLKPEKK 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  470 KAQGS-LIEDYQEKLSNAEEK--------------IELMKQEFQKKEAEWELSREDLKRDA-EEKLAsmflELREKAESE 533
Cdd:NF033838  306 VAEAEkKVEEAKKKAKDQKEEdrrnyptntyktleLEIAESDVKVKEAELELVKEEAKEPRnEEKIK----QAKAKVESK 381


                  .
gi 392355279  534 K 534
Cdd:NF033838  382 K 382
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1328-1550 3.41e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 3.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1328 KKDLADQQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELE-VVNSRNSEIEELKAIIEHLQENQEQLQKAKA 1406
Cdd:COG4942    21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALArRIRALEQELAALEAELAELEKEIAELRAELE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1407 EEIEQLHEVIEKLQselsLMGPTVHEMSDLPPGSLHTELSCLQAEGMGGQALHNELQAAQAAKGAFGQLladhghSQALE 1486
Cdd:COG4942   101 AQKEELAELLRALY----RLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAAL------RAELE 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392355279 1487 ALQERLQDAEAAAARHLTELEHCVALRQAEVEAMASRIQEFEATLKAKEAIIVQRDLEIDAVNK 1550
Cdd:COG4942   171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEA 234
PTZ00121 PTZ00121
MAEBL; Provisional
 2131-2454 3.52e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2131 AALTSTEARGSQREHQLRRQVELLAYKVEqEKCIANDLQKTlSKEQEAASDVRKRLMVEQGAVQDLKSELHACKQENTNL 2210
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKADEAKKKAE-EAKKADEAKKK-AEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKK 1490

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2211 LESLDKVQQEVLRLRAVLDGKENELKVVLEELECERGKGQVLQAQQEEQQLRHLQREGQSSRALEELKISLEKQLAQNNQ 2290
Cdd:PTZ00121 1491 KAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAK 1570

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2291 LCVALKHERAAKDNLQKelQIEASRCEALLA-----------------QEKGQLSELRKSlEAERSRSLELSEALQHERL 2353
Cdd:PTZ00121 1571 KAEEDKNMALRKAEEAK--KAEEARIEEVMKlyeeekkmkaeeakkaeEAKIKAEELKKA-EEEKKKVEQLKKKEAEEKK 1647

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2354 LTEQLSRNAQEACARQDTQAQHALLRKLKAEKARALELEamlekvqKQAAHTQQQLEAQAQERCLELRREKEREL----E 2429
Cdd:PTZ00121 1648 KAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEED-------EKKAAEALKKEAEEAKKAEELKKKEAEEKkkaeE 1720

                         330       340
                  ....*....|....*....|....*..
gi 392355279 2430 LQRQRDEHKI--EQLQRLVRELRWKEE 2454
Cdd:PTZ00121 1721 LKKAEEENKIkaEEAKKEAEEDKKKAE 1747
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 1302-1422 2.15e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 43.08  E-value: 2.15e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   1302 AKLDEEVELLQE---KLREKLDGFN-ELVIKKDLA------DQQLL-IQEEEIKHLEETNENIQRQMAQLQEELEkqrrs 1370
Cdd:smart00787  161 KLLMKELELLNSikpKLRDRKDALEeELRQLKQLEdeledcDPTELdRAKEKLKKLLQEIMIKVKKLEELEEELQ----- 235

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 392355279   1371 teELE-VVNSRNSEIEELKAIIEHLQENQEQLQKAKAEEIEQLHEVIEKLQSE 1422
Cdd:smart00787  236 --ELEsKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFKEIEKLKEQLKLLQSL 286
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 198-345 2.70e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 42.56  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  198 QETAELKEKFRSEMEKTVQMMETLKQDWESeRELCLETLRKELSAKHQSEMEGLQNQFQKELSEQKAELEKifQAKHEAE 277
Cdd:cd16269   149 EDREKLVEKYRQVPRKGVKAEEVLQEFLQS-KEAEAEAILQADQALTEKEKEIEAERAKAEAAEQERKLLE--EQQRELE 225

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  278 VSLKNLEAQHQAAIRKLQEDLRSEHCQYLQDLE--LRFREKEKAKELELETLQASyedlkAQSQEEIRHL 345
Cdd:cd16269   226 QKLEDQERSYEEHLRQLKEKMEEERENLLKEQEraLESKLKEQEALLEEGFKEQA-----ELLQEEIRSL 290
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1327-1601 2.96e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.51  E-value: 2.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1327 IKKDLADQQLLIQ----EEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELEVVNSRNSEIEELKAIIEHLQENQEQLQ 1402
Cdd:TIGR02168  218 LKAELRELELALLvlrlEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEI 297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1403 KAKAEEIEQLHEVIEKLQSELSlMGPTVHEMSDLPPGSLHTELSCLQAEGMGGQALHNELQAAQAAKGAFGQLLadhghS 1482
Cdd:TIGR02168  298 SRLEQQKQILRERLANLERQLE-ELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEEL-----E 371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1483 QALEALQERLQDAEAAAArhltELEHCVALRQAEVEAMASRIQEFEATLKAKEAIIVQRDLEIDAVNKWKVSHSVELEAL 1562
Cdd:TIGR02168  372 SRLEELEEQLETLRSKVA----QLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEE 447

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 392355279  1563 LLALAHFQHA-VEQQTSATPDEPPKLQQLLVQCARLSHQL 1601
Cdd:TIGR02168  448 ELEELQEELErLEEALEELREELEEAEQALDAAERELAQL 487
BspD6I-like cd22316
nicking endonuclease Nt.BspD6I and similar endonucleases; Heterodimeric type II restriction ...
 1302-1422 3.22e-03

nicking endonuclease Nt.BspD6I and similar endonucleases; Heterodimeric type II restriction endonuclease nicking endonuclease BspD6I recognizes a pseudosymmetric DNA sequence (5'-GAGTC) and cuts both strands outside the recognition motif 4 nucleotides downstream. It forms the large subunit in a heterodimeric arrangement. This catalytic domain/subunit belongs to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


Pssm-ID: 411720  Cd Length: 345  Bit Score: 42.67  E-value: 3.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1302 AKLDEEVELLQEKLREKLDGFNELVIKKDLADqqlliqeeeIKHLEETNENIQRQMAQLQEELEKQRRSTEELEVVNS-- 1379
Cdd:cd22316    38 EKKVEVEEILSNVERKPIFFDSDDDYLEYLFN---------PALPPLDNDDKANLVLELLRIRLKERGILIKISSKPLlt 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 392355279 1380 ---RNSEIEELKAIIEHLQENQeqLQKAKAEEIEQLHEVIEKLQSE 1422
Cdd:cd22316   109 padLNIIRKELENKLKKLREKK--YAKRQAEDWEEILEYFDLIENR 152
 
Name Accession Description Interval E-value
PACT_coil_coil pfam10495
Pericentrin-AKAP-450 domain of centrosomal targeting protein; This domain is a coiled-coil ...
 2647-2725 7.33e-27

Pericentrin-AKAP-450 domain of centrosomal targeting protein; This domain is a coiled-coil region close to the C-terminus of centrosomal proteins that is directly responsible for recruiting AKAP-450 and pericentrin to the centrosome. Hence the suggested name for this region is a PACT domain (pericentrin-AKAP-450 centrosomal targeting). This domain is also present at the C-terminus of coiled-coil proteins from Drosophila and S. pombe, and that from the Drosophila protein is sufficient for targeting to the centrosome in mammalian cells. The function of these proteins is unknown but they seem good candidates for having a centrosomal or spindle pole body location. The final 22 residues of this domain in AKAP-450 appear specifically to be a calmodulin-binding domain indicating that this member at least is likely to contribute to centrosome assembly.


Pssm-ID: 463115  Cd Length: 77  Bit Score: 105.75  E-value: 7.33e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392355279  2647 YLRAESFRKALIYQKKYLLLLIGGFQDSEQETLSMIAHLGVFPSKADKKvtaSRPFTRFRTAVRVVIAVLRLRFLVKKW 2725
Cdd:pfam10495    2 LLREESFRKDLAYQKKYLLLLLGGYQACNKADLRLLAQMGVTPPDDRPS---RKPRRKLKSAALAVIAIARMKRLAREW 77
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 462-1422 6.74e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 78.17  E-value: 6.74e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   462 LDLQLEQPKAQGSLIEDYQEkLSNAEEKIE--LMKQEFQKKEAEWELSREDLKRDAEEKLAsmfLELREKAESEKLSIIN 539
Cdd:TIGR02168  198 LERQLKSLERQAEKAERYKE-LKAELRELElaLLVLRLEELREELEELQEELKEAEEELEE---LTAELQELEEKLEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   540 -RFELRESSMRHLQD---QQAAQISDLERSLREQQGHLRQLEQELTRDEvllcsqcgkepsvAQDEKsailLREKEDCAL 615
Cdd:TIGR02168  274 lEVSELEEEIEELQKelyALANEISRLEQQKQILRERLANLERQLEELE-------------AQLEE----LESKLDELA 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   616 QLLTAQNRFLEERKEIMEKFAKEQDAFLLDTQEKHSHELQLLQQGHQQQLLALRMELETKhhsELTEQLASLESKQQALl 695
Cdd:TIGR02168  337 EELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIA---SLNNEIERLEARLERL- 412

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   696 ethvAKMQVKHDAEISALEKrhlsnldELESCYVADIQTIRDEHKKALELLRAELEEQLQKKDSCHREILTQELEKLKLK 775
Cdd:TIGR02168  413 ----EDRRERLQQEIEELLK-------KLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAE 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   776 HAEELQSVRNSLRVKMSAQHTESGKGPAADLQGAHQKAPAMALHNEGHQLEEDGDAALGGADTEDLQHhaepreregpht 855
Cdd:TIGR02168  482 RELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGRLQA------------ 549

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   856 VEMQTSQTELakpqELQASQDQGAQVRDQVFLLSReleeCRGELEQLQQRRERENQEGATLICMLRADVDlaqsegKALR 935
Cdd:TIGR02168  550 VVVENLNAAK----KAIAFLKQNELGRVTFLPLDS----IKGTEIQGNDREILKNIEGFLGVAKDLVKFD------PKLR 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   936 DALRRLLD--LFGETLKAAVTLKSRISERAGLLLdhedavdtsgaqlaaaalgemwpdeglLDIDRTLPEGAETSSVCEI 1013
Cdd:TIGR02168  616 KALSYLLGgvLVVDDLDNALELAKKLRPGYRIVT---------------------------LDGDLVRPGGVITGGSAKT 668

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1014 SShvcesffmspeNTQECEQPIRKvyqsLSTAVEGLLDMALDSSKQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLE 1093
Cdd:TIGR02168  669 NS-----------SILERRREIEE----LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRK 733

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1094 RLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEE----NSVLW 1169
Cdd:TIGR02168  734 DLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAldelRAELT 813

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1170 NQKETFTNeAKEREAALQKEVESLTRDQWESRKQSEKDRATLLSqmrvLESELEDQLVQhrgCAQLAEEVTTLKQQLATL 1249
Cdd:TIGR02168  814 LLNEEAAN-LRERLESLERRIAATERRLEDLEEQIEELSEDIES----LAAEIEELEEL---IEELESELEALLNERASL 885

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1250 DKHLRSQRQFMDEqaaerehereeFQQEIKWLEGQLRQATRPRppGPRDSQCAKLDEEVELLQEKLREKLDGFNELVIkk 1329
Cdd:TIGR02168  886 EEALALLRSELEE-----------LSEELRELESKRSELRREL--EELREKLAQLELRLEGLEVRIDNLQERLSEEYS-- 950

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1330 dladqqllIQEEEIKHLEETNENiqrQMAQLQEELEKQRRSTEELEVVNSRN-SEIEELKAIIEHLQENQEQLQKAKaee 1408
Cdd:TIGR02168  951 --------LTLEEAEALENKIED---DEEEARRRLKRLENKIKELGPVNLAAiEEYEELKERYDFLTAQKEDLTEAK--- 1016

                          970
                   ....*....|....
gi 392355279  1409 iEQLHEVIEKLQSE 1422
Cdd:TIGR02168 1017 -ETLEEAIEEIDRE 1029
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 120-587 5.35e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 75.36  E-value: 5.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  120 LELEALRLSLNNMHTAQLELTQANLQKEKETALTELREMLNGRRAQELALLQSRQQCELELMREQHAREKEEmaLRNEQE 199
Cdd:COG1196   274 LELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE--LEEAEE 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  200 TAELKEKFRSEMEKTVQMMETLKQDWESERELCLETLRKELSAkhQSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEVS 279
Cdd:COG1196   352 ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA--AAELAAQLEELEEAEEALLERLERLEEELEELEEA 429

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  280 LKNLEAQHQAAIRKLQEDLRSEhcQYLQDLELRFREKEKAKELELETLQASYEDLKAQSQEEIRHLWSQLEsMKTNREEQ 359
Cdd:COG1196   430 LAELEEEEEEEEEALEEAAEEE--AELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLE-AEADYEGF 506

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  360 NGSWEPLLAQASHLEELQHLRSDFAQQQQQERAQHESELEHLRVYFEKKLNDAEKtyqedLTVFQQRLQEAREESLESAE 439
Cdd:COG1196   507 LEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAA-----AIEYLKAAKAGRATFLPLDK 581

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  440 ISSSCMFPEETSGRERKEPPDPLDLQLEQPKAQGSLIEDYQEKLSNAEEKIELMKQEFQKKEAEWELSREDlkRDAEEKL 519
Cdd:COG1196   582 IRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLE--GEGGSAG 659

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392355279  520 ASMFLELREKAESEKLSIINRFELRESSMRHLQDQQAAQISDLERSLREQQGHLRQLEQELTRDEVLL 587
Cdd:COG1196   660 GSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALE 727
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1079-1419 5.77e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 72.02  E-value: 5.77e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1079 EEMAQAVQKQQELLERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEESEQQlivELEDLRKQLQQASREL 1158
Cdd:TIGR02169  677 QRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKE---RLEELEEDLSSLEQEI 753

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1159 LTLKEENSVLWNQKETFTNEAKEREAALQKEVESLTRDQWESRKQS----EKDRATLLSQMRVLESELEDQlvqHRGCAQ 1234
Cdd:TIGR02169  754 ENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAElsklEEEVSRIEARLREIEQKLNRL---TLEKEY 830

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1235 LAEEVTTLKQQLATLDkhlrSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQAtrprppgprDSQCAKLDEEVELLQEK 1314
Cdd:TIGR02169  831 LEKEIQELQEQRIDLK----EQIKSIEKEIENLNGKKEELEEELEELEAALRDL---------ESRLGDLKKERDELEAQ 897

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1315 LREKLDGFNELVIKKDLADQQLL-------IQEEEIKHLEETNENIQRQMA------QLQEELEKQRRSTEELEVVNsrN 1381
Cdd:TIGR02169  898 LRELERKIEELEAQIEKKRKRLSelkakleALEEELSEIEDPKGEDEEIPEeelsleDVQAELQRVEEEIRALEPVN--M 975

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 392355279  1382 SEIEELKAIIEHLQENQEQLQKAKAEEiEQLHEVIEKL 1419
Cdd:TIGR02169  976 LAIQEYEEVLKRLDELKEKRAKLEEER-KAILERIEEY 1012
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 144-716 1.77e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 70.35  E-value: 1.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  144 LQKEKETAL--TELREMLNGRRAQELALLQSRQQCELELMREQHAREKEEMAlRNEQETAELKEKFRSEMEKTVQMMETL 221
Cdd:COG1196   205 LERQAEKAEryRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELE-ELEAELAELEAELEELRLELEELELEL 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  222 KQDWESERELCLETLRKELSAKHQSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEVSLKNLEAQHQAAIRKLQEDLRSE 301
Cdd:COG1196   284 EEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEA 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  302 HCQYLQDLELRFREKEKAKELELETLQAsyEDLKAQSQEEIRHLWSQLESMKTNREEQNGSWEPLLAQASHLEELQHLRS 381
Cdd:COG1196   364 EEALLEAEAELAEAEEELEELAEELLEA--LRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE 441

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  382 DFAQQQQQERAQHESELEHLRVYFEKKLNDAEKTYQEDLTVFQQRLQEAREESLESAEISSSCMFPEETSGRERKEPPDP 461
Cdd:COG1196   442 EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRG 521

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  462 LDLQLEQPKAQGSLIEDYQEKLSNAEEKIELMKQEFQKKEAEWELSREDLKRDAEEKLASMFLELREKAESEKLSIINRF 541
Cdd:COG1196   522 LAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAV 601

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  542 ELRESSMRHLQDQQAAQISDLERSLREQQGHLRQLEQELTRDEVLLCSQCGKEpsVAQDEKSAILLREKEDCALQLLTAQ 621
Cdd:COG1196   602 DLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGE--GGSAGGSLTGGSRRELLAALLEAEA 679

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  622 NRFLEERKEIMEKFAKEQDAFLLDTQEKHSHELQLLQQGHQQQLLALRMELETKHHSELTEQLASLESKQQALLETHVAK 701
Cdd:COG1196   680 ELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEP 759

                         570
                  ....*....|....*.
gi 392355279  702 MQV-KHDAEISALEKR 716
Cdd:COG1196   760 PDLeELERELERLERE 775
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1120-1423 5.28e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 68.93  E-value: 5.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1120 KVEKADLQEALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEEnsvlWNQKETFTNEAKEREAALQKEVESLTRDQWE 1199
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKE----LEELSRQISALRKDLARLEAEVEQLEERIAQ 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1200 SRKQSEKDRATLLSQMRVLESELEDQLVQHRGCAQLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEIK 1279
Cdd:TIGR02168  752 LSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLER 831

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1280 WLEGQLRQATRprppgpRDSQCAKLDEEVELLQEKLREKLDGFNELVIKKDLADQQLLIQEEEIKHLEETNENIQRQMAQ 1359
Cdd:TIGR02168  832 RIAATERRLED------LEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRE 905

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392355279  1360 LQEELEKQRRSTEEL-EVVNSRNSEIEELKAIIEHLQENQEQLQKAKAEEIEQLHEVIEKLQSEL 1423
Cdd:TIGR02168  906 LESKRSELRRELEELrEKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEA 970
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2104-2404 7.91e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.04  E-value: 7.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2104 LLAEIQALRAQLRMTHLqnqEKLQQLCAALTSTEARGSQREHQLRRQVELLAYKVEQEKCIANDLQKTLSKEQEAASDVR 2183
Cdd:COG1196   218 LKEELKELEAELLLLKL---RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELL 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2184 KRLMVEQGAVQDLKSELHACKQENTNLLESLDKVQQEVLRLRAVLDGKENELKVVLEELEcergkgqVLQAQQEEQQLRH 2263
Cdd:COG1196   295 AELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE-------EAEAELAEAEEAL 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2264 LQREGQSSRALEELKISLEKQLAQNNQLCVALKHERaakdNLQKELQIEASRCEALLAQEKGQLSELRKSLEAERSRSLE 2343
Cdd:COG1196   368 LEAEAELAEAEEELEELAEELLEALRAAAELAAQLE----ELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEA 443

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392355279 2344 LSEALQ-HERLLTEQLSRNAQEACARQDTQAQHALLRKLKAEKARALELEAMLEKVQKQAAH 2404
Cdd:COG1196   444 LEEAAEeEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEG 505
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2148-2455 1.39e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 67.27  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2148 RRQVELLAYKVEqekcianDLQKTLSKEQEAASDVRKRLMVEQGAVQDLKSELHACKQENTNLLESLDKVQQEVLRLRAV 2227
Cdd:COG1196   224 ELEAELLLLKLR-------ELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2228 LDGKENELKVVLEELEcergkgqvlqaqqeeqqlRHLQREGQSSRALEELKISLEKQLAQNNQLCVALKHERAAKDNLQK 2307
Cdd:COG1196   297 LARLEQDIARLEERRR------------------ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEA 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2308 ELQIEASRCEALLAQEKGQLSELRKSLEAERSRSLELSEALQHERLLTEQLSRNAQEAcARQDTQAQHALLRKLKAEKAR 2387
Cdd:COG1196   359 ELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERL-ERLEEELEELEEALAELEEEE 437

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392355279 2388 ALELEAMLEKVQKQAAHTQQQLEAqaqercLELRREKERELELQRQRDEHKIEQLQRLVRELRWKEEA 2455
Cdd:COG1196   438 EEEEEALEEAAEEEAELEEEEEAL------LELLAELLEEAALLEAALAELLEELAEAAARLLLLLEA 499
PTZ00121 PTZ00121
MAEBL; Provisional
 154-779 3.77e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 66.32  E-value: 3.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  154 ELREMLNGRRAQELALLQSRQQCElELMREQHAREKEEMalRNEQETAELKEKFRSEMEKTVQMMETLKQDWESERELCL 233
Cdd:PTZ00121 1138 DARKAEEARKAEDAKRVEIARKAE-DARKAEEARKAEDA--KKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKA 1214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  234 ETLRKELSAKHQSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEVSLKNLEAQHQAAI-----RKLQEDLRSEHCQYLQD 308
Cdd:PTZ00121 1215 EEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIkaeeaRKADELKKAEEKKKADE 1294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  309 LElRFREKEKAKELELETLQASYEDLKAQSQEEIRhlwSQLESMKTNREEQNGSWEPLLAQAShleelqhlrsdfAQQQQ 388
Cdd:PTZ00121 1295 AK-KAEEKKKADEAKKKAEEAKKADEAKKKAEEAK---KKADAAKKKAEEAKKAAEAAKAEAE------------AAADE 1358

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  389 QERAQHESELEHLRVYFEKKLNDAEKTYQEDLTVFQQRLQEAREESLESAEISSScmfpeetsgRERKEPPDPLDLQLEQ 468
Cdd:PTZ00121 1359 AEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKA---------AAAKKKADEAKKKAEE 1429

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  469 PKAQGSLIEDYQEKLSNAEEKI---ELMKQEFQKKEAEWELSREDLKRDAEEKLASMflELREKAES--EKLSIINRFEL 543
Cdd:PTZ00121 1430 KKKADEAKKKAEEAKKADEAKKkaeEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAD--EAKKKAEEakKKADEAKKAAE 1507

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  544 RESSMRHLQDQQAAQISDLERSLREQQG--HLRQLEQELTRDEVLLCSQCGKEPSVAQDEKSAillREKEDCALQLLTAQ 621
Cdd:PTZ00121 1508 AKKKADEAKKAEEAKKADEAKKAEEAKKadEAKKAEEKKKADELKKAEELKKAEEKKKAEEAK---KAEEDKNMALRKAE 1584

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  622 NRFLEERKEIMEKFAKEQDAFLLDTQEKHSHELQLLQQGHQQQLLALRMELETKHHSElTEQLASLESKQQALLETHVAK 701
Cdd:PTZ00121 1585 EAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKE-AEEKKKAEELKKAEEENKIKA 1663

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  702 MQVKHDAEISALEKRHLSNLDElESCYVADIQTIRDEHKKALELLRAELEEQLQKKDSCHR--EILTQELEKLKLKHAEE 779
Cdd:PTZ00121 1664 AEEAKKAEEDKKKAEEAKKAEE-DEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKaeEENKIKAEEAKKEAEED 1742
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1058-1545 9.17e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.57  E-value: 9.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1058 KQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEESE 1137
Cdd:COG1196   239 AELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERL 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1138 QQLIVELEDLRKQLQQASRELLTLKEENSVLWNQKETFTNEAKEREAALQKEVESLTRDQwESRKQSEKDRATLLSQMRV 1217
Cdd:COG1196   319 EELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE-EELEELAEELLEALRAAAE 397

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1218 LESELEDQLVQHRGCAQLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQATRprppgpr 1297
Cdd:COG1196   398 LAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLE------- 470

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1298 dsQCAKLDEEVELLQEKLREKLDgfNELVIKKDLADQQLLIQEEEIKHLEETNENIQRQMAQLQ---EELEKQRRSTEEL 1374
Cdd:COG1196   471 --EAALLEAALAELLEELAEAAA--RLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIgveAAYEAALEAALAA 546

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1375 EVVNSRNSEIEELKAIIEHLQENQ---------EQLQKAKAEEIEQLHEVIEKLQSELSLMGPTVHEMSDLPPGSLHTEL 1445
Cdd:COG1196   547 ALQNIVVEDDEVAAAAIEYLKAAKagratflplDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRT 626

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1446 SCLQAEGMGGQAL------HNELQAAQAAKGAFGQLLADHGHSQALEALQERLQDAEAAAARHLTELEHCVALRQAEVEA 1519
Cdd:COG1196   627 LVAARLEAALRRAvtlagrLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEE 706

                         490       500
                  ....*....|....*....|....*.
gi 392355279 1520 MASRIQEFEATLKAKEAIIVQRDLEI 1545
Cdd:COG1196   707 RELAEAEEERLEEELEEEALEEQLEA 732
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1058-1689 9.28e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 64.69  E-value: 9.28e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1058 KQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEESE 1137
Cdd:TIGR02168  288 KELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAEL 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1138 QQLIVELEDLRKQLQQASRELLTLKEENSVLWNQKEtftnEAKEREAALQKEVESLTRDQWE-SRKQSEKDRATLLSQMR 1216
Cdd:TIGR02168  368 EELESRLEELEEQLETLRSKVAQLELQIASLNNEIE----RLEARLERLEDRRERLQQEIEElLKKLEEAELKELQAELE 443

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1217 VLESELEDQLVQHRGC-----------AQLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEF--QQEIKWLEG 1283
Cdd:TIGR02168  444 ELEEELEELQEELERLeealeelreelEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLknQSGLSGILG 523

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1284 QLRQATRPRP----------PGPRDSQCAKLDEEVELLQEKLREKLDGFNELVIKKDLADQQLLIQEEEIKHLEETN--- 1350
Cdd:TIGR02168  524 VLSELISVDEgyeaaieaalGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFlgv 603

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1351 -------------------------ENIQRQMAQLQEELEKQRRSTEELEVVN-----------------SRNSEIEELK 1388
Cdd:TIGR02168  604 akdlvkfdpklrkalsyllggvlvvDDLDNALELAKKLRPGYRIVTLDGDLVRpggvitggsaktnssilERRREIEELE 683

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1389 AIIEHLQENQEQLQKA---KAEEIEQLHEVIEKLQSELSLMGPTVHEMSDLPPGSLHTELSCL----QAEGMGGQALHNE 1461
Cdd:TIGR02168  684 EKIEELEEKIAELEKAlaeLRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEeriaQLSKELTELEAEI 763

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1462 LQAAQAAKGAFGQLLADHGHSQALEALQERLQDAEAAAARHLTELEHCVALRQAEVEAMASRIQEFEATLKAKEAIIVQR 1541
Cdd:TIGR02168  764 EELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDL 843

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1542 DLEIDAVNK--WKVSHSVELEALLLALAHFQHAVEQQTSATPDEPPK-----LQQLLVQCARLSHQLHVLYRRFLRCQVE 1614
Cdd:TIGR02168  844 EEQIEELSEdiESLAAEIEELEELIEELESELEALLNERASLEEALAllrseLEELSEELRELESKRSELRRELEELREK 923

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392355279  1615 LGQHQPRVasvgcadppAEAQGKRDGELEQdgvssglALAPHSLVAQAKEEQPEDCHLGNTSLRAQLRQLEEKLD 1689
Cdd:TIGR02168  924 LAQLELRL---------EGLEVRIDNLQER-------LSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1040-1552 1.16e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.19  E-value: 1.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1040 QSLSTAVEGLLDMALDSSKQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRLALELHTAEGLLEGF 1119
Cdd:COG1196   263 AELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEEL 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1120 KVEKADLQEALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEENSVLWNQKETFTNEAKEREAALQKEVESLTRDQwE 1199
Cdd:COG1196   343 EEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLE-E 421

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1200 SRKQSEKDRATLLSQMRVLESELEDQLVQHRGCAQLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEIK 1279
Cdd:COG1196   422 ELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEA 501

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1280 WLEGQLRQATRPR--PPGPRDSQCAKLDEEVELLQEKLREKLDGFNELVIKKDLADQQLLIQEEEIKHLEETNENIQRQM 1357
Cdd:COG1196   502 DYEGFLEGVKAALllAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDK 581

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1358 AQLQEELEKQRRSTEELEVVNSRNSEIEELKAIIEHLQENQ--EQLQKAKAEEIEQLHEVIEKLQSELSLmgptvhEMSD 1435
Cdd:COG1196   582 IRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLlgRTLVAARLEAALRRAVTLAGRLREVTL------EGEG 655

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1436 LPPGSLHTElscLQAEGMGGQALHNELQAAQAAKGAFGQLLADHGHSQALEALQERLQDAEAAAARHLTELEhcvALRQA 1515
Cdd:COG1196   656 GSAGGSLTG---GSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEE---ALEEQ 729

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 392355279 1516 EVEAMASRIQEFEATLKAKEAIIVQRDLEIDAVNKWK 1552
Cdd:COG1196   730 LEAEREELLEELLEEEELLEEEALEELPEPPDLEELE 766
PTZ00121 PTZ00121
MAEBL; Provisional
 135-648 2.47e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 63.62  E-value: 2.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  135 AQLELTQANLQKEKETALTELREMLNGRRAQELALLQSRQQCELELMREQHAREKEEMALRNEQ---ETAELKEKF---- 207
Cdd:PTZ00121 1263 AHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEakkKADAAKKKAeeak 1342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  208 ------RSEMEKTVQMMETLKQDWESERELCLETLRKELSAKHQSEMEGLQNQFQKELSEQK----------AELEKIFQ 271
Cdd:PTZ00121 1343 kaaeaaKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKkkadelkkaaAAKKKADE 1422

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  272 AKHEAEVSLKNLEAQHQAAIRKLQEDLR--SEHCQYLQDLELRFREKEKAKELELETLQASYEDLKAQSQEEIRHLWSQL 349
Cdd:PTZ00121 1423 AKKKAEEKKKADEAKKKAEEAKKADEAKkkAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEA 1502

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  350 ---ESMKTNREEQNGSWEPLLAQASHLEELQHLRSDFAQQQQQERAQHESELEHLRVYFEKKLNDAEKTYQEDLTVFQQR 426
Cdd:PTZ00121 1503 kkaAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRK 1582

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  427 LQEAREESLESAEISSSCMFPEETSGRERKEPPDPLDLQLEQ-PKAQGSLIEDYQEKLSNAEEKIElmKQEFQKKEAEWE 505
Cdd:PTZ00121 1583 AEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEElKKAEEEKKKVEQLKKKEAEEKKK--AEELKKAEEENK 1660

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  506 LSREDLKR-DAEEKLASMFLELREKAESEKLSIINRFELRESSMRHLQDQQAAQISDLERSLREQQGHLRQLEQELTRDE 584
Cdd:PTZ00121 1661 IKAAEEAKkAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAE 1740

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392355279  585 VLlcSQCGKEPSVAQDEKSAI--LLREKEDCALQLLTAQNRFLEER-KEIMEKFAKEQDAFLLDTQE 648
Cdd:PTZ00121 1741 ED--KKKAEEAKKDEEEKKKIahLKKEEEKKAEEIRKEKEAVIEEElDEEDEKRRMEVDKKIKDIFD 1805
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1146-1494 2.51e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 63.15  E-value: 2.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1146 DLRKQLQQASRELLTLKeensvlWNQKETFTNEAKEREAALQKEVESLTRDQwesrKQSEKDRATLLSQMRVLESELEDQ 1225
Cdd:TIGR02168  217 ELKAELRELELALLVLR------LEELREELEELQEELKEAEEELEELTAEL----QELEEKLEELRLEVSELEEEIEEL 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1226 lvQHRgCAQLAEEVTTLKQQLATLD---KHLRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQATrprppGPRDSQCA 1302
Cdd:TIGR02168  287 --QKE-LYALANEISRLEQQKQILRerlANLERQLEELEAQLEELESKLDELAEELAELEEKLEELK-----EELESLEA 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1303 KLDEEVELLQE---KLREKLDGFNELVIKKDLADQQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELEVVNS 1379
Cdd:TIGR02168  359 ELEELEAELEElesRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKEL 438

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1380 RnSEIEELKAIIEHLQENQEQLQKAKAEEIEQLHEVIEKLQSELSlmgptvhEMSDLppGSLHTELSCLQAEGMG-GQAL 1458
Cdd:TIGR02168  439 Q-AELEELEEELEELQEELERLEEALEELREELEEAEQALDAAER-------ELAQL--QARLDSLERLQENLEGfSEGV 508

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 392355279  1459 HNELQAAQAAKGAFGQLL----ADHGHSQALE-ALQERLQD 1494
Cdd:TIGR02168  509 KALLKNQSGLSGILGVLSelisVDEGYEAAIEaALGGRLQA 549
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 869-1428 2.70e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.03  E-value: 2.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  869 QELQASQDQGAQVRDQVFLLSRELEECRGELEQLQQRRERENQEGATLicmlRADVDLAQSEGKALRDALRRLLDLFGET 948
Cdd:COG1196   239 AELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEA----QAEEYELLAELARLEQDIARLEERRREL 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  949 LKAAVTLKSRISERAGLLLDHEDAVDTSGAQLAAAALGEMWPDEGLLDIDRTLPEgaetssvceisshvcesffmspent 1028
Cdd:COG1196   315 EERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLE------------------------- 369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1029 qeceqpIRKVYQSLSTAVEGLLDMALDSSKQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRLALE 1108
Cdd:COG1196   370 ------AEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEA 443

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1109 LHTAEGLLEGFKVEKADLQEALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEENSVLWNQKETFTNEAKEREAALQK 1188
Cdd:COG1196   444 LEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLA 523

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1189 EVESLTRDQWESRKQSEKDRATLLSQMRVLESELEDQLVQHRGCAQLAEEVTTL------KQQLATLDKHLRSQRQFMDE 1262
Cdd:COG1196   524 GAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLpldkirARAALAAALARGAIGAAVDL 603

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1263 QAAEREHEREEFQQEIKWLEGQLRQATRPRPPGPRDSQCAKLDEEVELLQEKLREKLDGFNELVIKKDLADQQLLIQEEE 1342
Cdd:COG1196   604 VASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEE 683

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1343 IKHLEETNENIQRQMAQLQEELEKQRRSTEELEVVNSRNSEIEELKAIIEHLQENQEQLQKAKAEE------------IE 1410
Cdd:COG1196   684 LAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEeealeelpeppdLE 763

                         570
                  ....*....|....*...
gi 392355279 1411 QLHEVIEKLQSELSLMGP 1428
Cdd:COG1196   764 ELERELERLEREIEALGP 781
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1086-1424 3.84e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 59.31  E-value: 3.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1086 QKQQELLERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEESEQQLIV-ELEDLRKQLQQASRELLTLKEE 1164
Cdd:TIGR02169  173 EKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGYELLkEKEALERQKEAIERQLASLEEE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1165 nsvlwnqKETFTNEAKEREAALQKEVESLTRDQWESRKQSEKDRATLLSQMRVLESELEdqlvqhrgcaQLAEEVTTLKQ 1244
Cdd:TIGR02169  253 -------LEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIA----------SLERSIAEKER 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1245 QLatldkhlrsqrQFMDEQAAEREHEREEFQQEIKWLEGQLRQATRPRppgprdsqcAKLDEEVELLQEKLREKLDGFNE 1324
Cdd:TIGR02169  316 EL-----------EDAEERLAKLEAEIDKLLAEIEELEREIEEERKRR---------DKLTEEYAELKEELEDLRAELEE 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1325 LVIKKDLADQQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEEL------------EVVNSRNSEIEELKAIIE 1392
Cdd:TIGR02169  376 VDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLnaaiagieakinELEEEKEDKALEIKKQEW 455

                          330       340       350
                   ....*....|....*....|....*....|..
gi 392355279  1393 HLQENQEQLQKAKaEEIEQLHEVIEKLQSELS 1424
Cdd:TIGR02169  456 KLEQLAADLSKYE-QELYDLKEEYDRVEKELS 486
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 869-1419 9.00e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.02  E-value: 9.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  869 QELQASQDQGAQVRDQVFLLSRELEECRGELEQLQQRRERENQEGATL---ICMLRADVDLAQSEGKALRDALRRLLDLF 945
Cdd:COG1196   274 LELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELeeeLAELEEELEELEEELEELEEELEEAEEEL 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  946 GETLKAAVTLKSRISERAGLLLDHEDAVDTSGAQLAAAALGEMWPDEGLLDIDRTLPEGAETSSVCEisshvcesffmsp 1025
Cdd:COG1196   354 EEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLE------------- 420

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1026 ENTQECEQPIRKVYQSLSTAVEGLLDMALDSSKQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRL 1105
Cdd:COG1196   421 EELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAE 500

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1106 ALELHTAEGLLEGFKVEKA-----DLQEALGKKEESEQQLIVEL-----EDLRKQLQQASRELLTLKEENSvlwnQKETF 1175
Cdd:COG1196   501 ADYEGFLEGVKAALLLAGLrglagAVAVLIGVEAAYEAALEAALaaalqNIVVEDDEVAAAAIEYLKAAKA----GRATF 576

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1176 TNEAKEREAALQKEVESLTRDQWESRKQSEKDRATLLSQMRVLESELEDQLVQHR-GCAQLAEEVTTLKQQLATLDKHLR 1254
Cdd:COG1196   577 LPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARlEAALRRAVTLAGRLREVTLEGEGG 656

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1255 SQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQATRPRPPGPRDSQCAKLDEEVELLQEKLREKLDGFNELVIKKDLADQ 1334
Cdd:COG1196   657 SAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREE 736

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1335 QLLIQEEEIKHLEETNENIQRQM---AQLQEELEKQRRSTEELEVVNSRnsEIEELKAIIEHLQENQEQLQKAKaEEIEQ 1411
Cdd:COG1196   737 LLEELLEEEELLEEEALEELPEPpdlEELERELERLEREIEALGPVNLL--AIEEYEELEERYDFLSEQREDLE-EARET 813


                  ....*...
gi 392355279 1412 LHEVIEKL 1419
Cdd:COG1196   814 LEEAIEEI 821
PTZ00121 PTZ00121
MAEBL; Provisional
 147-781 9.64e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 58.23  E-value: 9.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  147 EKETALTELREMLNGRRAQELALLQSRQQCELELMREQHAREKEEMALRNEQETAELKEKFRSEMEKTVQMMETLKQDWE 226
Cdd:PTZ00121 1209 EEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEE 1288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  227 SERELCL---ETLRKELSAKHQSEMEGLQNQFQKELSEQKAELEkifQAKHEAEVSLKNLEAQHQAAIRKLQEDLRSEhc 303
Cdd:PTZ00121 1289 KKKADEAkkaEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKAD---AAKKKAEEAKKAAEAAKAEAEAAADEAEAAE-- 1363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  304 qylqdlelrfrEKEKAKELELETLQASYEDLKAQSQEEirhlwSQLESMKTNREEQNGSWEPLLAQASHLEELQHLRSDF 383
Cdd:PTZ00121 1364 -----------EKAEAAEKKKEEAKKKADAAKKKAEEK-----KKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKA 1427

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  384 AQQQQQERAQHESELehlrvyfEKKLNDAEKTYQEdltvfQQRLQEAREESLESAEISsscmfpEETSGRERKEPPDPLD 463
Cdd:PTZ00121 1428 EEKKKADEAKKKAEE-------AKKADEAKKKAEE-----AKKAEEAKKKAEEAKKAD------EAKKKAEEAKKADEAK 1489

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  464 LQLEQPKAQGSLIEDYQEKLSNAEE--KIELMKQEFQKKEAEWELSREDLKRDAEEKLASmflELREKAESEKLSIINRF 541
Cdd:PTZ00121 1490 KKAEEAKKKADEAKKAAEAKKKADEakKAEEAKKADEAKKAEEAKKADEAKKAEEKKKAD---ELKKAEELKKAEEKKKA 1566

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  542 E--LRESSMRHLQDQQAAQISDLERSLREQQGHLRQLEQELTRDEVllcsqcgkepSVAQDEK-SAILLREKEDCALQLL 618
Cdd:PTZ00121 1567 EeaKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEA----------KKAEEAKiKAEELKKAEEEKKKVE 1636

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  619 TAQNRFLEERKEIMEKFAKEQDAFLLDTQEKHSHELQLLQQGHQQQLLALRMELETKHHSELTEQLASLESKQQALLETH 698
Cdd:PTZ00121 1637 QLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKK 1716

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  699 VAKmQVKHDAEISALEKRHLSNLDElESCYVADIQTIRDEHKKALELLRAELEEQLQKKDSCHREILTQELEKLKLKHAE 778
Cdd:PTZ00121 1717 KAE-ELKKAEEENKIKAEEAKKEAE-EDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRM 1794


                  ...
gi 392355279  779 ELQ 781
Cdd:PTZ00121 1795 EVD 1797
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 136-543 2.06e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 56.99  E-value: 2.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   136 QLELTQANLQKeKETALTELREMLNGRRAQELALLQSRqqcelELMREQHAREKEEMALRNEQETAELkEKFRSEMEKTV 215
Cdd:TIGR02168  180 KLERTRENLDR-LEDILNELERQLKSLERQAEKAERYK-----ELKAELRELELALLVLRLEELREEL-EELQEELKEAE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   216 QMMETLkQDWESERELCLETLRKElsakhQSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEVSLKNLEAQHQAAIRKLQ 295
Cdd:TIGR02168  253 EELEEL-TAELQELEEKLEELRLE-----VSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLE 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   296 EDLRSEHCQylqdlelrfREKEKAKELELETLQASYEDLKAQSQEEIRhlwsQLESMKTNREEQNgswepllaqashlEE 375
Cdd:TIGR02168  327 ELESKLDEL---------AEELAELEEKLEELKEELESLEAELEELEA----ELEELESRLEELE-------------EQ 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   376 LQHLRSDFAqQQQQERAQHESELEHLrvyfEKKLNDAEKTYQEdltvfQQRLQEAREESLESAEIssscmfpeetsgrer 455
Cdd:TIGR02168  381 LETLRSKVA-QLELQIASLNNEIERL----EARLERLEDRRER-----LQQEIEELLKKLEEAEL--------------- 435

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   456 keppDPLDLQLEQPKAQgslIEDYQEKLSNAEEKIELMKQEFQKKEAEWELSREDLKRDAEEK--LASMFLELREKAESE 533
Cdd:TIGR02168  436 ----KELQAELEELEEE---LEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLdsLERLQENLEGFSEGV 508

                          410
                   ....*....|
gi 392355279   534 KLSIINRFEL 543
Cdd:TIGR02168  509 KALLKNQSGL 518
PTZ00121 PTZ00121
MAEBL; Provisional
 208-916 2.10e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.07  E-value: 2.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  208 RSEMEKTVQMMETLKqdwESERELCLETLRKELSAKHQSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEVSLKNLEAQH 287
Cdd:PTZ00121 1059 KAEAKAHVGQDEGLK---PSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARK 1135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  288 QAAIRKLQEDLRSEHCQYLQDLelrfREKEKAKELELetlqasyedlkAQSQEEIRHLWSQLESMKTNREEQngsweplL 367
Cdd:PTZ00121 1136 AEDARKAEEARKAEDAKRVEIA----RKAEDARKAEE-----------ARKAEDAKKAEAARKAEEVRKAEE-------L 1193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  368 AQASHLEELQHLRsdfaqqqqqeRAQHESELEHLRVYFEKKLNDAEKTYQEdltvFQQRLQEAREESLESAEISSSCMFP 447
Cdd:PTZ00121 1194 RKAEDARKAEAAR----------KAEEERKAEEARKAEDAKKAEAVKKAEE----AKKDAEEAKKAEEERNNEEIRKFEE 1259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  448 EETSGRERKEPPDPLDlqlEQPKAQGSLIEDYQEKLSNAEEKIELMKQEFQKKEAEWELSREDLKRDAEE--KLASmflE 525
Cdd:PTZ00121 1260 ARMAHFARRQAAIKAE---EARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEakKKAD---A 1333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  526 LREKAE-SEKLSIINRFELRESSMRHLQDQQAAQISDLERSLREQQGHLRQLEQELTRDEVLLCSQCGKEPSVAQDEKSA 604
Cdd:PTZ00121 1334 AKKKAEeAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKA 1413

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  605 ILLREKEDcALQLLTAQNRFLEERKEIMEKfAKEQDAFLLDTQEKHSHELQLLQQGHQQQLLALRMELETKHHSELTEQL 684
Cdd:PTZ00121 1414 AAAKKKAD-EAKKKAEEKKKADEAKKKAEE-AKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKK 1491

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  685 ASlESKQQALLETHVAKMQVKHDAEISALEKRHLSNLDELESCYVADIQTIRDEHKKALELLRAELEEQLQKKDSCHREI 764
Cdd:PTZ00121 1492 AE-EAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAK 1570

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  765 LTQELEKLKLKHAEELQSVRNSLRVKMSAQHTESGKGPAADLQGAHQ-KAPAMALHNEghQLEEDGDAALGGADTEDLQH 843
Cdd:PTZ00121 1571 KAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEaKIKAEELKKA--EEEKKKVEQLKKKEAEEKKK 1648

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392355279  844 HAEPREREGPHTV----EMQTSQTELAKPQELQASQDQGAQVRDQvflLSRELEECRgELEQLQQRRERENQEGATL 916
Cdd:PTZ00121 1649 AEELKKAEEENKIkaaeEAKKAEEDKKKAEEAKKAEEDEKKAAEA---LKKEAEEAK-KAEELKKKEAEEKKKAEEL 1721
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1058-1423 2.34e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 56.61  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1058 KQLEDARQLHRCVEKEFrhrdEEMAQAVQKQQELLERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEESE 1137
Cdd:PRK03918  186 KRTENIEELIKEKEKEL----EEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKI 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1138 QQL---IVELEDLRKQLQQASRELLTLKEEnSVLWNQKETFTNEAKEREAALQKEVESLTRDQWESRKQSEK--DRATLL 1212
Cdd:PRK03918  262 RELeerIEELKKEIEELEEKVKELKELKEK-AEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKEleEKEERL 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1213 SQMRVLESELEDQLVQHRGCAQLAEEVTTLKQQLATLDKHLrsqrqfmdeqaaeREHEREEFQQEIKWLEgqlrqatrpr 1292
Cdd:PRK03918  341 EELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRL-------------TGLTPEKLEKELEELE---------- 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1293 ppgprdsqcaKLDEEVELLQEKLREKLDGFNELVIKKDLADQQL------------LIQEEEIKHLEETN----ENIQRQ 1356
Cdd:PRK03918  398 ----------KAKEEIEEEISKITARIGELKKEIKELKKAIEELkkakgkcpvcgrELTEEHRKELLEEYtaelKRIEKE 467

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392355279 1357 MAQLQEELEKQRRSTEELEVVNSRNSEIEELKAIIEHLQENQEQLQKAKAEEIEQLHEVIEKLQSEL 1423
Cdd:PRK03918  468 LKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKL 534
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 273-1164 3.63e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 56.22  E-value: 3.63e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   273 KHEAEvslKNLEAQHQAAIRklQEDLRSEHCQYLQDLElrfREKEKAKEleletlqasYEDLKaqsqEEIRHLwsQLESM 352
Cdd:TIGR02168  174 RKETE---RKLERTRENLDR--LEDILNELERQLKSLE---RQAEKAER---------YKELK----AELREL--ELALL 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   353 KTNREEQNGSWEPLLAQashLEELQHLRSDFAQQQQQERAQHEsELEHLRVYFEKKLNDAEKTYQE------DLTVFQQR 426
Cdd:TIGR02168  231 VLRLEELREELEELQEE---LKEAEEELEELTAELQELEEKLE-ELRLEVSELEEEIEELQKELYAlaneisRLEQQKQI 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   427 LQEAREESLESAEissscmfpeetsgrerkeppdPLDLQLEQPKAQgslIEDYQEKLSNAEEKIELMKQEFQKKEAEWEl 506
Cdd:TIGR02168  307 LRERLANLERQLE---------------------ELEAQLEELESK---LDELAEELAELEEKLEELKEELESLEAELE- 361

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   507 SREDLKRDAEEKLAsmflELREKAESEKLsiiNRFELRESsmrhlQDQQAAQISDLERSLREQQGHLRQLEQELtrdevl 586
Cdd:TIGR02168  362 ELEAELEELESRLE----ELEEQLETLRS---KVAQLELQ-----IASLNNEIERLEARLERLEDRRERLQQEI------ 423

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   587 lcSQCGKEPSVAQDEKSAILLREKEDCALQLLTAQNRFLEERKEIMEKFAKEQDAFLLDTQEKHSHELQLLQQGHQQQll 666
Cdd:TIGR02168  424 --EELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQE-- 499

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   667 alrmeletkHHSELTEQLASLESKQQALLETH-VAKMQVKHDAEIS-----ALEKRHLSNLDELESCYVADIQTIRdEHK 740
Cdd:TIGR02168  500 ---------NLEGFSEGVKALLKNQSGLSGILgVLSELISVDEGYEaaieaALGGRLQAVVVENLNAAKKAIAFLK-QNE 569

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   741 KALELLRAELEEQLQKKDSCHREILTQELEKLKLkhAEELQSVRNSLRVKMSAqhTESGKGPAADLQGAHQKAPAMALHN 820
Cdd:TIGR02168  570 LGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGV--AKDLVKFDPKLRKALSY--LLGGVLVVDDLDNALELAKKLRPGY 645

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   821 -----EGHQLEEDGDAALGGADTEDLQHHAEPREREGPHTVEMQTSQTELAKpQELQASQDQGAQVRDQVFLLSRELEEC 895
Cdd:TIGR02168  646 rivtlDGDLVRPGGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELE-KALAELRKELEELEEELEQLRKELEEL 724

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   896 RGELEQLQQRRERENQEGATLicmlRADVDLAQSEGKALRDALRRLLDLFGETLKAAVTLKSRISERAGLLLDHEDAVDT 975
Cdd:TIGR02168  725 SRQISALRKDLARLEAEVEQL----EERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKA 800

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   976 SGAQLAAAALgemwpdegllDIDRTLPEGAETSSVCEISSHVCESFFMSPENTQECEQPIRKVYQSLSTAVEGLLDMALD 1055
Cdd:TIGR02168  801 LREALDELRA----------ELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE 870

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1056 SSKQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEE 1135
Cdd:TIGR02168  871 LESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYS 950

                          890       900       910
                   ....*....|....*....|....*....|
gi 392355279  1136 SEQQLIVELEDLR-KQLQQASRELLTLKEE 1164
Cdd:TIGR02168  951 LTLEEAEALENKIeDDEEEARRRLKRLENK 980
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2169-2455 4.33e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.83  E-value: 4.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2169 QKTLSKEQEAAsDVRKRLMVEQGAVQDLKSELHACKQENTNLLESLDKVQQEVLRLRAVLDGKENELKVVLEELEcergk 2248
Cdd:TIGR02168  670 SSILERRREIE-ELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE----- 743

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2249 gqvlqaqqeeqqlRHLQREGQSSRALEELKISLEKQLAQNNQLCVALKherAAKDNLQKElqieasrcEALLAQEKGQLS 2328
Cdd:TIGR02168  744 -------------QLEERIAQLSKELTELEAEIEELEERLEEAEEELA---EAEAEIEEL--------EAQIEQLKEELK 799

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2329 ELRKSLEAERSRSLELSEALQHERLLTEQLSRNAQEACAR-QDTQAQHALLRKLKAEKARALE-LEAMLEKVQKQAAHtq 2406
Cdd:TIGR02168  800 ALREALDELRAELTLLNEEAANLRERLESLERRIAATERRlEDLEEQIEELSEDIESLAAEIEeLEELIEELESELEA-- 877

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 392355279  2407 QQLEAQAQERCLELRREKERELELQRQRDEHKIEQLQRLVRELRWKEEA 2455
Cdd:TIGR02168  878 LLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQ 926
PTZ00121 PTZ00121
MAEBL; Provisional
 138-471 5.57e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.53  E-value: 5.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  138 ELTQANLQKEKEtaltELREMLNGRRAQELALLQSRQQCELELMREQHAREKEE--MALRNEQETAELKEKFRSEMEKTV 215
Cdd:PTZ00121 1526 EAKKAEEAKKAD----EAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDknMALRKAEEAKKAEEARIEEVMKLY 1601

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  216 QMMETLKQDW---ESERELCLETLRKELSAKHQSEmeglqnQFQKELSEQKAELEKIFQAKHEAEVSLKNLEAQHQAAIR 292
Cdd:PTZ00121 1602 EEEKKMKAEEakkAEEAKIKAEELKKAEEEKKKVE------QLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKK 1675

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  293 KLQEDLRSEHCQYLQDLELRFREKEKAKELELETLQASyEDLKAQS---QEEIRHLwsQLESMKTNREEQNGSWEPLLAQ 369
Cdd:PTZ00121 1676 KAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAE-EKKKAEElkkAEEENKI--KAEEAKKEAEEDKKKAEEAKKD 1752

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  370 ASHLEELQHLRSDFAQQQQQERAQHESEL-EHLRVYFEKKLNDAEKTYQEDLTVFQQRLQEAREESLESAEissscmfPE 448
Cdd:PTZ00121 1753 EEEKKKIAHLKKEEEKKAEEIRKEKEAVIeEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVIND-------SK 1825

                         330       340
                  ....*....|....*....|...
gi 392355279  449 ETSGRERKEPPDPLDLQLEQPKA 471
Cdd:PTZ00121 1826 EMEDSAIKEVADSKNMQLEEADA 1848
PTZ00121 PTZ00121
MAEBL; Provisional
 1055-1393 6.88e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.53  E-value: 6.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1055 DSSKQLEDARQLHRCVEKEFRHRDEEMAQAVQ-KQQELLERLREESAAKDRLALELHTAEgllEGFKVEKADLQEALGKK 1133
Cdd:PTZ00121 1525 DEAKKAEEAKKADEAKKAEEKKKADELKKAEElKKAEEKKKAEEAKKAEEDKNMALRKAE---EAKKAEEARIEEVMKLY 1601

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1134 EESEQqliVELEDLRKQLQQASR--ELLTLKEENSVLWNQKETFTNEAKEREAALQKEVESLTRDQWESRKQSEKDRatl 1211
Cdd:PTZ00121 1602 EEEKK---MKAEEAKKAEEAKIKaeELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKK--- 1675

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1212 lsQMRVLESELEDQLVQHRGCAQLAEEvttlKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQATRP 1291
Cdd:PTZ00121 1676 --KAEEAKKAEEDEKKAAEALKKEAEE----AKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEA 1749

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1292 RPPGPRDSQCAKLDEEVELLQEKLR-EKLDGFNELVIKKDlaDQQLLIQEEEIKHLEETNENIQR--QMAQLQEELEKQR 1368
Cdd:PTZ00121 1750 KKDEEEKKKIAHLKKEEEKKAEEIRkEKEAVIEEELDEED--EKRRMEVDKKIKDIFDNFANIIEggKEGNLVINDSKEM 1827

                         330       340
                  ....*....|....*....|....*
gi 392355279 1369 RSTEELEVVNSRNSEIEELKAIIEH 1393
Cdd:PTZ00121 1828 EDSAIKEVADSKNMQLEEADAFEKH 1852
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2137-2450 7.12e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.06  E-value: 7.12e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2137 EARGSQREHQLRRQVE-----LLAYKVEQEKCIANDLQKTLSKEQEAASDVRKRLMVEQGAVQDLKSELHackqentNLL 2211
Cdd:TIGR02168  208 QAEKAERYKELKAELRelelaLLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVS-------ELE 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2212 ESLDKVQQEVLRLRAVLDGKENELKVVLEELEcergkgqvLQAQQEEQQLRHLQREGQSSRALEELKISLEKQLAQNNQL 2291
Cdd:TIGR02168  281 EEIEELQKELYALANEISRLEQQKQILRERLA--------NLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEE 352

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2292 CVALKHERAAKDNLQKELQIEASRCEALLAQEKGQLSELRKSLEAERSRSLELSEALqherlltEQLSRNAQEACARQDT 2371
Cdd:TIGR02168  353 LESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARL-------ERLEDRRERLQQEIEE 425

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392355279  2372 QAQHALLRKLKAEKARALELEAMLEKVQKQAAHTQQQLEAQAQErcLELRREKERELELQRQRDEHKIEQLQRLVRELR 2450
Cdd:TIGR02168  426 LLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREE--LEEAEQALDAAERELAQLQARLDSLERLQENLE 502
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 158-495 7.36e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.06  E-value: 7.36e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   158 MLNGRRAQELALLQSRQQcelELmrEQHAREKEEMALRNEQETAELKEKfRSEMEKTVQMMETLKQDWES-ERELCLETL 236
Cdd:TIGR02168  660 VITGGSAKTNSSILERRR---EI--EELEEKIEELEEKIAELEKALAEL-RKELEELEEELEQLRKELEElSRQISALRK 733

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   237 RKELSAKHQSEMEGLQNQFQKELSEQKAE-------LEKIFQAKHEAEVSLKNLEA---QHQAAIRKLQEDLRSEHCQY- 305
Cdd:TIGR02168  734 DLARLEAEVEQLEERIAQLSKELTELEAEieeleerLEEAEEELAEAEAEIEELEAqieQLKEELKALREALDELRAELt 813

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   306 -LQDLELRFREKEKAKELELETLQASYEDLKAQS---QEEIRHLWSQLESMKTNREEQNGSWEPLLAQASHLEELQHLRS 381
Cdd:TIGR02168  814 lLNEEAANLRERLESLERRIAATERRLEDLEEQIeelSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLR 893

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   382 DFAQQQQQERAQHESELEHLRVYFEkKLNDAEKTYQEDLTVFQQRLQEAREESLESAEISsscmfPEETSGRERKEPPDP 461
Cdd:TIGR02168  894 SELEELSEELRELESKRSELRRELE-ELREKLAQLELRLEGLEVRIDNLQERLSEEYSLT-----LEEAEALENKIEDDE 967

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 392355279   462 LDLQLEQPKAQGSL----------IEDYQEKlsnAEEKIELMKQ 495
Cdd:TIGR02168  968 EEARRRLKRLENKIkelgpvnlaaIEEYEEL---KERYDFLTAQ 1008
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 119-579 9.21e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 54.84  E-value: 9.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   119 SLELEALRLSLNNMHTAQLELTQANLQKEKETALTELREMLNGRRAQeLALLQSRQQCELELMREQHAREKEEMALRNEQ 198
Cdd:pfam12128  252 TLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQ-WKEKRDELNGELSAADAAVAKDRSELEALEDQ 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   199 ETAELKEkfrsEMEKTVQMMETLKQdWESERELcLETLRKELSAKHQSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEV 278
Cdd:pfam12128  331 HGAFLDA----DIETAAADQEQLPS-WQSELEN-LEERLKALTGKHQDVTAKYNRRRSKIKEQNNRDIAGIKDKLAKIRE 404

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   279 SLKNLEAQHQAAIRKLQEDLRSEHCQYLQDL-ELRFREKEKAKELELETLQASY-EDLK---AQSQEEIRHLWSQLESMK 353
Cdd:pfam12128  405 ARDRQLAVAEDDLQALESELREQLEAGKLEFnEEEYRLKSRLGELKLRLNQATAtPELLlqlENFDERIERAREEQEAAN 484

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   354 TNREeqngSWEPLLAQASHLEELQHLRSDFAQQQQQERAQHESELEHLrvyfekkLNDAEKTYQEDLTVFQQRLQEAREE 433
Cdd:pfam12128  485 AEVE----RLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQ-------LFPQAGTLLHFLRKEAPDWEQSIGK 553

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   434 SLESAEISSSCMFPEETSGR--------------ERKEPPDPLDL--QLEQPKAQ-GSLIEDYQEKLSNAEEKIELMKQE 496
Cdd:pfam12128  554 VISPELLHRTDLDPEVWDGSvggelnlygvkldlKRIDVPEWAASeeELRERLDKaEEALQSAREKQAAAEEQLVQANGE 633

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   497 FQKKEAEWELSREDLKrDAEEKLASMFLELREKAESEKLSIINRFELRESSMRHLQDQQAAQISDLERSLREQQGHLRQL 576
Cdd:pfam12128  634 LEKASREETFARTALK-NARLDLRRLFDEKQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREA 712


                   ...
gi 392355279   577 EQE 579
Cdd:pfam12128  713 RTE 715
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1058-1427 1.08e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 54.39  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1058 KQLEDARQLHRCVEKEFRHRDEEMAQaVQKQQELLERLREESAAKDRLALELHTAEGLLEGFKvEKADLQEALGKKEESE 1137
Cdd:COG4717    95 EELEELEEELEELEAELEELREELEK-LEKLLQLLPLYQELEALEAELAELPERLEELEERLE-ELRELEEELEELEAEL 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1138 QQLIVELEDLRKQLQQASR-ELLTLKEENSVLWNQKETFTNE---AKEREAALQKEVESLTRDQWESRKQSEKDRATLLS 1213
Cdd:COG4717   173 AELQEELEELLEQLSLATEeELQDLAEELEELQQRLAELEEEleeAQEELEELEEELEQLENELEAAALEERLKEARLLL 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1214 QMRVLESELEDQLVQHRGCAQLAEEVTTLKQQLATLDkHLRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQATRPRP 1293
Cdd:COG4717   253 LIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALL-FLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLP 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1294 PGPRDSQCAKLDEEVELLQEKLREKLDGFNELVIKKDLADQQLLIQEEEIKHLEETNENIQ--RQMAQLQEELEKQRRST 1371
Cdd:COG4717   332 PDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEqaEEYQELKEELEELEEQL 411

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 392355279 1372 EELEVVNSRNSEIEELKAIIEHLQENQEQLQkAKAEEIEQLHEVIEKLQSELSLMG 1427
Cdd:COG4717   412 EELLGELEELLEALDEEELEEELEELEEELE-ELEEELEELREELAELEAELEQLE 466
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
257-639 1.25e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 54.30  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  257 KELSEQKAELEKIFQAKHEAEVSLKNLEAQHQAAIRKLQE------DLRSEhcqyLQDLELRFREKEKAKEL--ELETLQ 328
Cdd:PRK03918  172 KEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEisselpELREE----LEKLEKEVKELEELKEEieELEKEL 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  329 ASYEDLKAQSQEEIRHLWSQLESMKTNREEqngswepLLAQASHLEELQhlrsdfaqqqqqERAQHESELEHLRVYFEKK 408
Cdd:PRK03918  248 ESLEGSKRKLEEKIRELEERIEELKKEIEE-------LEEKVKELKELK------------EKAEEYIKLSEFYEEYLDE 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  409 LNDAEKT---YQEDLTVFQQRLQEAREESLESAEISSscmfpEETSGRERKEPPDPLDLQLEQPKAQGSLIEDYQEKLSN 485
Cdd:PRK03918  309 LREIEKRlsrLEEEINGIEERIKELEEKEERLEELKK-----KLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTG 383

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  486 AE-EKIELMKQEFQKKEAEWElsredlkrDAEEKLASMFLELREKAESEKLSIIN-----------RFELRESSMRHLQD 553
Cdd:PRK03918  384 LTpEKLEKELEELEKAKEEIE--------EEISKITARIGELKKEIKELKKAIEElkkakgkcpvcGRELTEEHRKELLE 455

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  554 QQAAQISDLERSLREQQGHLRQLEQELTRDEVLLcsqcGKEPSVAQDEKSAILLREKED----CALQLLTAQNRFLEERK 629
Cdd:PRK03918  456 EYTAELKRIEKELKEIEEKERKLRKELRELEKVL----KKESELIKLKELAEQLKELEEklkkYNLEELEKKAEEYEKLK 531

                         410
                  ....*....|
gi 392355279  630 EIMEKFAKEQ 639
Cdd:PRK03918  532 EKLIKLKGEI 541
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1061-1414 1.33e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 54.28  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1061 EDARQLHRCVEKEFRHRdEEMAQAVQKQQELLERLREE-SAAKDRLALELHTAEGLlegfkvekADLQEALGKKEESEQQ 1139
Cdd:PRK02224  258 AEIEDLRETIAETERER-EELAEEVRDLRERLEELEEErDDLLAEAGLDDADAEAV--------EARREELEDRDEELRD 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1140 livELEDLRKQLQQASRELLTLKEENSVLwnqkETFTNEAKEREAALQKEVESlTRDQWESRkqsEKDRATLLSQMRVLE 1219
Cdd:PRK02224  329 ---RLEECRVAAQAHNEEAESLREDADDL----EERAEELREEAAELESELEE-AREAVEDR---REEIEELEEEIEELR 397

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1220 SELEDQLVQHRGCA----QLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREH-----------------EREEFQQEI 1278
Cdd:PRK02224  398 ERFGDAPVDLGNAEdfleELREERDELREREAELEATLRTARERVEEAEALLEAgkcpecgqpvegsphveTIEEDRERV 477

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1279 KWLEGQLRQAtrprppgprDSQCAKLDEEVELLqEKLREKLDGFNELVIKKDLADQQLLIQEEEIKHLEETNENIQRQMA 1358
Cdd:PRK02224  478 EELEAELEDL---------EEEVEEVEERLERA-EDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAA 547

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1359 QLQEELEKQRRSTEE----------------------------LEVVNSRNSEIEELKAIIEHLQENQEQLQKAKAEEIE 1410
Cdd:PRK02224  548 ELEAEAEEKREAAAEaeeeaeeareevaelnsklaelkeriesLERIRTLLAAIADAEDEIERLREKREALAELNDERRE 627


                  ....
gi 392355279 1411 QLHE 1414
Cdd:PRK02224  628 RLAE 631
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 123-790 1.81e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 53.82  E-value: 1.81e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   123 EALRLSLNNMHTAQLELTQANLQKEKETALTELREMLNGRRAQE----LALLQSRQQCELELMREQHAREKEEMALR--- 195
Cdd:pfam02463  181 ETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEyllyLDYLKLNEERIDLLQELLRDEQEEIESSKqei 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   196 -NEQETAELKEKFRSEMEKTVQMMETLKQDWESERELCLETLRKELSAKH--QSEMEGLQNQFQKELSEQKAELEKIFQA 272
Cdd:pfam02463  261 eKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVddEEKLKESEKEKKKAEKELKKEKEEIEEL 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   273 KHEAEVSLKNLEA-----QHQAAIRKLQEDLRSEHCQYLQDLELRFREKEKAKELELEtlqasYEDLKAQSQEEIRHLWS 347
Cdd:pfam02463  341 EKELKELEIKREAeeeeeEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELE-----LKSEEEKEAQLLLELAR 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   348 QLESMKTNREEQngswepllaQASHLEELQHLRsDFAQQQQQERAQHESELEHLRVYFEKKLNDAEKTYQEDLTVFQQRL 427
Cdd:pfam02463  416 QLEDLLKEEKKE---------ELEILEEEEESI-ELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQ 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   428 QEAREESLESAEISSSCMFPEETSGRERKEPPDPLDLQLEQPKAQGSLIEDYQEKLSNAEEKIELMKQEFQKKEAEWELS 507
Cdd:pfam02463  486 LELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQK 565

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   508 REDLKRDAEEKLASMFLELREKAESEKLSIINRFELRessMRHLQDQQAAQISDLERSLR-EQQGHLRQLEQELTRDEVL 586
Cdd:pfam02463  566 LVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPI---LNLAQLDKATLEADEDDKRAkVVEGILKDTELTKLKESAK 642

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   587 LCSQCGKEPSVAQDEKSAILLREKEDCALQLLTAQNRFLEERKEIMEKFAKEQDAflldtQEKHSHELQLLQQGHQQQLL 666
Cdd:pfam02463  643 AKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRR-----QLEIKKKEQREKEELKKLKL 717

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   667 ALRMELETKHHSELTEQLASLESKQQALLETHVAKMQVKHDAEISALEKRHLSNLDELESCYVADIQTIRDEHKKALELL 746
Cdd:pfam02463  718 EAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLK 797

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 392355279   747 RAELEEQLQKKDSCHREILTQELEKLKLKHAEELQSVRNSLRVK 790
Cdd:pfam02463  798 AQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALE 841
PTZ00121 PTZ00121
MAEBL; Provisional
 1073-1422 5.03e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.45  E-value: 5.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1073 EFRHRDEEMAQAVQKQQELLERLREESAAKDrlALELHTAEGLLEgfKVEKADLQEALGKKEESEQQLivelEDLRKQLQ 1152
Cdd:PTZ00121 1422 EAKKKAEEKKKADEAKKKAEEAKKADEAKKK--AEEAKKAEEAKK--KAEEAKKADEAKKKAEEAKKA----DEAKKKAE 1493

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1153 QASRELLTLKEENSVLWNQKETFTNEAKEREAALQKEVESLTRDqwESRKQSEKDRATLLSQMRVLESELEDQLVQHrgc 1232
Cdd:PTZ00121 1494 EAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKAD--EAKKAEEKKKADELKKAEELKKAEEKKKAEE--- 1568

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1233 AQLAEEVTTLKQQLATLDKHLRSQRqfmdeqaaeREHEREEFQQEIKWLEGQLRQATRPRPPGPRDSQCAKLDEEVELLQ 1312
Cdd:PTZ00121 1569 AKKAEEDKNMALRKAEEAKKAEEAR---------IEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLK 1639

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1313 EKLREKLDGFNELviKKdlADQQLLIQEEEIKHLEETNeniQRQMAQLQEELEKQRRSTEELEVVNSRNSEIEELKAIIE 1392
Cdd:PTZ00121 1640 KKEAEEKKKAEEL--KK--AEEENKIKAAEEAKKAEED---KKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEA 1712

                         330       340       350
                  ....*....|....*....|....*....|
gi 392355279 1393 HLQENQEQLQKAKAEEIEQLHEVIEKLQSE 1422
Cdd:PTZ00121 1713 EEKKKAEELKKAEEENKIKAEEAKKEAEED 1742
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1058-1423 5.13e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 52.37  E-value: 5.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1058 KQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRLA-----LELHTAEGLLEGFKVEKADLQEALGK 1132
Cdd:PRK03918  391 KELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPvcgreLTEEHRKELLEEYTAELKRIEKELKE 470

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1133 KEESEQQLIVELEDLRKQLQQASR---------ELLTLKEENSVL----WNQKETFTNEAKEREAALQKEVESLTRDqWE 1199
Cdd:PRK03918  471 IEEKERKLRKELRELEKVLKKESEliklkelaeQLKELEEKLKKYnleeLEKKAEEYEKLKEKLIKLKGEIKSLKKE-LE 549

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1200 SRKQSEKDRATLLSQMRVLESELEDQLVQHRGCAQLAEEvttlkqqlaTLDKHLRSQRQFMDE--QAAEREHEREEFQQE 1277
Cdd:PRK03918  550 KLEELKKKLAELEKKLDELEEELAELLKELEELGFESVE---------ELEERLKELEPFYNEylELKDAEKELEREEKE 620

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1278 IKWLEGQLRQATRprppgprdsQCAKLDEEVELLQEKLREKLDGFNE-----LVIKKDLADQQLLIQEEEIKHLEETNEN 1352
Cdd:PRK03918  621 LKKLEEELDKAFE---------ELAETEKRLEELRKELEELEKKYSEeeyeeLREEYLELSRELAGLRAELEELEKRREE 691

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392355279 1353 IQRQMAQLQEELEKQRRSTEELEVVNSRNSEIEELKaiiehlqenqEQLQKAKAEEIEQLHEVIEKLQSEL 1423
Cdd:PRK03918  692 IKKTLEKLKEELEEREKAKKELEKLEKALERVEELR----------EKVKKYKALLKERALSKVGEIASEI 752
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 121-361 7.80e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.98  E-value: 7.80e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   121 ELEALRLSLNNMHTAQLELTQANLQKEKETALTELREMLNGRRAQELallqSRQQCELELMREQHAREKEEMAL---RNE 197
Cdd:TIGR02168  268 KLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANL----ERQLEELEAQLEELESKLDELAEelaELE 343

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   198 QETAELKEKFRS------EMEKTVQMMETLKQDWESErelcLETLRKELsAKHQSEMEGLQNQFQkELSEQKAELEKifQ 271
Cdd:TIGR02168  344 EKLEELKEELESleaeleELEAELEELESRLEELEEQ----LETLRSKV-AQLELQIASLNNEIE-RLEARLERLED--R 415

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   272 AKHEAEVSLKNLEAQHQAAIRKLQEDLrSEHCQYLQDLELRFREKEKAKELELETLQASYEDLKaQSQEEIRHLWSQLES 351
Cdd:TIGR02168  416 RERLQQEIEELLKKLEEAELKELQAEL-EELEEELEELQEELERLEEALEELREELEEAEQALD-AAERELAQLQARLDS 493

                          250
                   ....*....|
gi 392355279   352 MKTNREEQNG 361
Cdd:TIGR02168  494 LERLQENLEG 503
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1051-1284 8.24e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 51.84  E-value: 8.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1051 DMALDSSKQLEDARQLhrcvEKEFR--HRDEEMAQAVQKQQELLERLREESAAKDRLALELHTAEGLLEGFKVEKAdlQE 1128
Cdd:COG4913   215 EYMLEEPDTFEAADAL----VEHFDdlERAHEALEDAREQIELLEPIRELAERYAAARERLAELEYLRAALRLWFA--QR 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1129 ALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEENSVLWNQKEtftNEAKEREAALQKEVESLTRDqwesRKQSEKDR 1208
Cdd:COG4913   289 RLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIR---GNGGDRLEQLEREIERLERE----LEERERRR 361

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392355279 1209 ATLLSQMRVLESELEDQLvqhrgcAQLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEF---QQEIKWLEGQ 1284
Cdd:COG4913   362 ARLEALLAALGLPLPASA------EEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELrelEAEIASLERR 434
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2106-2374 8.34e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.60  E-value: 8.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2106 AEIQALRAQLRMTHLQNQEKLQQLCAALTSTEARGSQREhQLR-------RQVELLAYKVEQEKCIANDLQKTLSKEQEA 2178
Cdd:TIGR02168  677 REIEELEEKIEELEEKIAELEKALAELRKELEELEEELE-QLRkeleelsRQISALRKDLARLEAEVEQLEERIAQLSKE 755

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2179 ASDVRKRLMVEQGAVQDLKSELHACKQENTNLLESLDKVQQEVLRLRAVLDGKENELKVVLEELEcERGKGQVLQAQQEE 2258
Cdd:TIGR02168  756 LTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAA-NLRERLESLERRIA 834

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2259 QQLRHLQREGQSSRALEELKISLEKQLAQNNQLCVALKHERAAKDNLQKELqieasrcEALLAQEKGQLSELRKSLEAER 2338
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASL-------EEALALLRSELEELSEELRELE 907

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 392355279  2339 SRSLELSEALQHERLLTEQLSRNAQEACARQDTQAQ 2374
Cdd:TIGR02168  908 SKRSELRRELEELREKLAQLELRLEGLEVRIDNLQE 943
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1030-1396 8.96e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 51.58  E-value: 8.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1030 ECEQPIRKVYQSLSTA---VEGLLDMALDSSKQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRLA 1106
Cdd:PRK02224  325 ELRDRLEECRVAAQAHneeAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAP 404

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1107 LELHTAEGLLEGFKVEK-----------ADLQEALGKKEESEQQL----------------IVE-LEDLRKQLQQASREL 1158
Cdd:PRK02224  405 VDLGNAEDFLEELREERdelrereaeleATLRTARERVEEAEALLeagkcpecgqpvegspHVEtIEEDRERVEELEAEL 484

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1159 LTLKEENSVLWNQKETFTNEAK-EREAALQKEVESLTRDQWESRKQSEKDRATLLSQMRVLESELEDQLVQHRGCAQLA- 1236
Cdd:PRK02224  485 EDLEEEVEEVEERLERAEDLVEaEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAe 564

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1237 -------EEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHereefqqeikwleGQLRQATRPRppgpRDSQCAKLDEEVE 1309
Cdd:PRK02224  565 eeaeearEEVAELNSKLAELKERIESLERIRTLLAAIADA-------------EDEIERLREK----REALAELNDERRE 627

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1310 LLQEK------LREKLDG--FNELVIKKDLADQQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELEVVNSRN 1381
Cdd:PRK02224  628 RLAEKrerkreLEAEFDEarIEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEELRERREALENRV 707

                         410
                  ....*....|....*
gi 392355279 1382 SEIEELKAIIEHLQE 1396
Cdd:PRK02224  708 EALEALYDEAEELES 722
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 486-1420 9.78e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 51.51  E-value: 9.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   486 AEEKIELMKQEFQKKEAEwELSREDLKRDAEEKLasmfLELREKAESEKLSIINRFELRESSMRHLQDQQAA----QISD 561
Cdd:pfam02463  143 KIEIIAMMKPERRLEIEE-EAAGSRLKRKKKEAL----KKLIEETENLAELIIDLEELKLQELKLKEQAKKAleyyQLKE 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   562 LERSLREQQGHLRQLEQELTRDEVLLcsqcGKEPSVAQDEKSAILLREKEDCALQLLTAQNRFLEERKEIMEKFAKEQDA 641
Cdd:pfam02463  218 KLELEEEYLLYLDYLKLNEERIDLLQ----ELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAK 293

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   642 FLldtQEKHSHELQLLQQGHQQQLLALRMELETKHHSELTEQLASLESKQQALLETHVAKMQVKHDAEISALEKRHLSNL 721
Cdd:pfam02463  294 EE---EELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   722 DELESCYVADIQTIRDEHKKALELLRAELEEQLQKKDSCHREILTQELEKLKLKHAEELQSVRNSLRVKMSAQhtesgkg 801
Cdd:pfam02463  371 LEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQ------- 443

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   802 paadlqgahqkapamaLHNEGHQLEEDGDAALGGADTEDLQHHAEPREREGPHTVEMQTSQTELAKPQELQASQDQGAQV 881
Cdd:pfam02463  444 ----------------GKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARS 507

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   882 RDQVFLLSRELEEcrGELEQLQQRRERENQEGATLICMLRADVDLAQSEGKALRDALRRLLDLFGETLKAAVTLKSRISE 961
Cdd:pfam02463  508 GLKVLLALIKDGV--GGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIP 585

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   962 RAGLLLDHeDAVDTSGAQLAAAALGEMWPDEGLLDIDRTLPEGAEtSSVCEISSHVCESFFMSPENTQECEQPIRKVYQS 1041
Cdd:pfam02463  586 KLKLPLKS-IAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGIL-KDTELTKLKESAKAKESGLRKGVSLEEGLAEKSE 663

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1042 LSTAVEGLLDMALDSSKQLEDARQLHRcvEKEFRHRDEEMAQAVQKQQELLERLREESAAKD--RLALELHTAEGLLEGF 1119
Cdd:pfam02463  664 VKASLSELTKELLEIQELQEKAESELA--KEEILRRQLEIKKKEQREKEELKKLKLEAEELLadRVQEAQDKINEELKLL 741

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1120 KVEKAD-LQEALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEENSVLWNQKETFTNEAKEREAALQKEVESLTRDQW 1198
Cdd:pfam02463  742 KQKIDEeEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQ 821

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1199 ESRKQSEKDRATLLSQMRVLESELEDQLVQHRGCAQLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEI 1278
Cdd:pfam02463  822 LLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKE 901

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1279 KWLEGQlrqatrprppgpRDSQCAKLDEEVELLQEKLREKLDGFNELviKKDLADQQLLIQEEEIKHLEETNENIQRQMA 1358
Cdd:pfam02463  902 LEEESQ------------KLNLLEEKENEIEERIKEEAEILLKYEEE--PEELLLEEADEKEKEENNKEEEEERNKRLLL 967

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392355279  1359 QLQEELEKQRRSTEELEVVNSRNSEIEElkaiiehlqenqeQLQKAKAEEIEQLHEVIEKLQ 1420
Cdd:pfam02463  968 AKEELGKVNLMAIEEFEEKEERYNKDEL-------------EKERLEEEKKKLIRAIIEETC 1016
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2029-2449 1.07e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.48  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2029 EKEALGTHLTWSEELLQAIQEVFAREQENAELQPRpYSSDLGDYNSLVKKLEKVIQEQGDLQKVREHAclpdRSSLLAEI 2108
Cdd:COG1196   367 LLEAEAELAEAEEELEELAEELLEALRAAAELAAQ-LEELEEAEEALLERLERLEEELEELEEALAEL----EEEEEEEE 441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2109 QALRAQLRmthlqNQEKLQQLCAALTSTEARGSQREHQLRRQVELLAYKVEQEKCIANDLQKTLSKEQEAASDVRKRLMV 2188
Cdd:COG1196   442 EALEEAAE-----EEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLL 516

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2189 EQ-----GAVQDLKSELHACKQENTNLLESLdkVQQEVLRLRAVLDGKENELKVVLEELEcERGKGQVLQAQQEEQQLRH 2263
Cdd:COG1196   517 AGlrglaGAVAVLIGVEAAYEAALEAALAAA--LQNIVVEDDEVAAAAIEYLKAAKAGRA-TFLPLDKIRARAALAAALA 593

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2264 LQREGQSSRALEELKISLEKQLAQNNQLCVALKHERAAKDNLQKELQIEASRCEALLAQEKGQLSELRKSLEAERSRSLE 2343
Cdd:COG1196   594 RGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAA 673

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2344 LSEALQHERLLTEQLSRNAQEACARQDTQAQHALLRKLKAEKARALELEAMLEKVQKQAAHTQQQLEAQAQERCLELRRE 2423
Cdd:COG1196   674 LLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEAL 753

                         410       420
                  ....*....|....*....|....*.
gi 392355279 2424 KERELELQRQRDEHKIEQLQRLVREL 2449
Cdd:COG1196   754 EELPEPPDLEELERELERLEREIEAL 779
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 233-842 1.26e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.09  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  233 LETLRKELSAKHQSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEVSLKNLEAQHQAAIRKLQEDLRSEhcqylQDLELR 312
Cdd:COG1196   222 LKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEE-----YELLAE 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  313 FREKEKAKELELETLQASYEDLkAQSQEEIRHLWSQLESMKTNREEQNGSwepLLAQASHLEELQHLRSDFAQQQQQERA 392
Cdd:COG1196   297 LARLEQDIARLEERRRELEERL-EELEEELAELEEELEELEEELEELEEE---LEEAEEELEEAEAELAEAEEALLEAEA 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  393 QHESELEHLrvyfeKKLNDAEKTYQEDLTVFQQRLQEAREESLESAEissscmfpeetsgrerkeppdpldlqleqpkAQ 472
Cdd:COG1196   373 ELAEAEEEL-----EELAEELLEALRAAAELAAQLEELEEAEEALLE-------------------------------RL 416

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  473 GSLIEDYQEKLSNAEEKIELMKQEFQKKEAEWELSREDLKRDAEEKLASMFLELREKAESEKLSIINRFELRESSMRHLQ 552
Cdd:COG1196   417 ERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLL 496

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  553 DQQAAQISDLERSLREQQGhlrQLEQELTRDEVLLCSQCGKEPSVAQDEKSAILLREKEDCALQLLTAQNRFLEERKEim 632
Cdd:COG1196   497 LEAEADYEGFLEGVKAALL---LAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKA-- 571

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  633 ekfakEQDAFLLDTQEKHSHELQLLQQGHQQQLLALrmeletkhhsELTEQLASLESKQQALLETHVAKMQVKHDAEISA 712
Cdd:COG1196   572 -----GRATFLPLDKIRARAALAAALARGAIGAAVD----------LVASDLREADARYYVLGDTLLGRTLVAARLEAAL 636

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  713 LEKRHLSNLDELESCYVADIQTIRDEHKKALELLRAELEEQLQKKDSCHREILTQELEKLKLKHAEELQSVRNSLRVKMS 792
Cdd:COG1196   637 RRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEER 716

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|
gi 392355279  793 AQHTESGKGPAADLQGAHQKAPAMALHNEGHQLEEDGDAALGGADTEDLQ 842
Cdd:COG1196   717 LEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELE 766
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 2077-2450 1.40e-05

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 50.91  E-value: 1.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2077 KKLEKVIQEQGDLQKVREHACLPDRSSLLAEIQALRAQLRMTHLQNQEKLQQL---CAALTSTEARGSQREHQLRRQVEL 2153
Cdd:pfam07111  284 EELTRKIQPSDSLEPEFPKKCRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLrgqVAELQEQVTSQSQEQAILQRALQD 363

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2154 LAYKVEQEKCIANDLQKTLSKEQEAAsdvRKRLMVEQGAVQDLKSELHACKQENTNLLESLDKVQQEVLRLRAVldgkEN 2233
Cdd:pfam07111  364 KAAEVEVERMSAKGLQMELSRAQEAR---RRQQQQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSL----SN 436

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2234 ELKVVLEELECERGkgqvlqaqqEEQQLRHLQREGQSSRALEELKISLEKQLAqnnqlcVALKHERAAKDNLQKELQI-- 2311
Cdd:pfam07111  437 RLSYAVRKVHTIKG---------LMARKVALAQLRQESCPPPPPAPPVDADLS------LELEQLREERNRLDAELQLsa 501

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2312 -----EASRCEALLAQEKGQLSELRKSLEAERSRS--------LELSEALQHERLLTEQLSRNAQEACARQDTQAQhALL 2378
Cdd:pfam07111  502 hliqqEVGRAREQGEAERQQLSEVAQQLEQELQRAqeslasvgQQLEVARQGQQESTEEAASLRQELTQQQEIYGQ-ALQ 580

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392355279  2379 RKLKAEKARALELEAMLEKVQKQAAHTQQQLEAQAQERCLELRREKERELELQRQRDEHKIEQLQRLVRELR 2450
Cdd:pfam07111  581 EKVAEVETRLREQLSDTKRRLNEARREQAKAVVSLRQIQHRATQEKERNQELRRLQDEARKEEGQRLARRVQ 652
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1044-1422 1.54e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 50.81  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1044 TAVEGLLDMALDSSKQLEDarQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREE----SAAKDRLALELHTAEGLLEGF 1119
Cdd:PRK02224  176 LGVERVLSDQRGSLDQLKA--QIEEKEEKDLHERLNGLESELAELDEEIERYEEQreqaRETRDEADEVLEEHEERREEL 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1120 KVEKADLQEALGKKEESEQqlivELEDLRKQLQQASRELLTLKEENSVLWNQKETftnEAKEREAALQKevesltRDQWE 1199
Cdd:PRK02224  254 ETLEAEIEDLRETIAETER----EREELAEEVRDLRERLEELEEERDDLLAEAGL---DDADAEAVEAR------REELE 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1200 SRKQSEKDRatlLSQMRVLESELEDQLVQHRGCA-QLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHereeFQQEI 1278
Cdd:PRK02224  321 DRDEELRDR---LEECRVAAQAHNEEAESLREDAdDLEERAEELREEAAELESELEEAREAVEDRREEIEE----LEEEI 393

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1279 KWLEGQLRQATRPRppgprdsqcakldEEVELLQEKLREKLDGFNELV---------IKKDLADQQLLIQE--------- 1340
Cdd:PRK02224  394 EELRERFGDAPVDL-------------GNAEDFLEELREERDELREREaeleatlrtARERVEEAEALLEAgkcpecgqp 460

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1341 -EEIKHLEETNENIQRqMAQLQEELEKQRRSTEELEVVNSRNSEIEELKAIIEHLQENQEQLQK----------AKAEEI 1409
Cdd:PRK02224  461 vEGSPHVETIEEDRER-VEELEAELEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEEliaerretieEKRERA 539

                         410
                  ....*....|...
gi 392355279 1410 EQLHEVIEKLQSE 1422
Cdd:PRK02224  540 EELRERAAELEAE 552
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1070-1423 1.69e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 50.40  E-value: 1.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1070 VEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGK---KEESEQQLIVELED 1146
Cdd:TIGR04523  129 LEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKiknKLLKLELLLSNLKK 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1147 LRKQLQQASRELLTLKEENSVLWNQKETFTNEAKEREAALQKEVESL--TRDQWESRKQSEKDRATLLSQMRVLESELED 1224
Cdd:TIGR04523  209 KIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLnqLKDEQNKIKKQLSEKQKELEQNNKKIKELEK 288

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1225 QLvqhrgcAQLAEEVTTLKQQ-LATLDKHLRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQATRPRPP-----GPRD 1298
Cdd:TIGR04523  289 QL------NQLKSEISDLNNQkEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNsesenSEKQ 362

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1299 SQCAKLDEEVELLQEKLREKLDGFNELVIKKDLADQQLLIQEE-------EIKHLEETNENIQRQMAQLQEELEKQRRST 1371
Cdd:TIGR04523  363 RELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKlnqqkdeQIKKLQQEKELLEKEIERLKETIIKNNSEI 442

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 392355279  1372 EELE-VVNSRNSEIEELKAIIEHLQENQEQLQKakaeEIEQLHEVIEKLQSEL 1423
Cdd:TIGR04523  443 KDLTnQDSVKELIIKNLDNTRESLETQLKVLSR----SINKIKQNLEQKQKEL 491
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1049-1451 2.29e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 50.11  E-value: 2.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1049 LLDMALDS-SKQLEDARQLHRCVEKEFrhrdEEMAQAVQKQQELLERLREESAAKDRLALELHTAEGLLEGFKVEKADLQ 1127
Cdd:pfam05483  381 IITMELQKkSSELEEMTKFKNNKEVEL----EELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLE 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1128 EALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEENSVLWNQKETFTNEAKEREAALQKEVESLTrdqwESRKQSEKd 1207
Cdd:pfam05483  457 IQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDII----NCKKQEER- 531

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1208 ratLLSQMRVLEseledqlvqhrgcaqlaEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQ 1287
Cdd:pfam05483  532 ---MLKQIENLE-----------------EKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKI 591

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1288 AtrprppgprDSQCAKLDEEVElLQEKLREKLDGFNELVIKKDLAD-QQLLIQEEEIKHLEETNENIQRQMAQL----QE 1362
Cdd:pfam05483  592 L---------ENKCNNLKKQIE-NKNKNIEELHQENKALKKKGSAEnKQLNAYEIKVNKLELELASAKQKFEEIidnyQK 661

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1363 ELEKQRRSTEELEvvnsrnSEIEELKAIIEHLQENQEQLQKAKAEEI-----------EQLHEVIEKLQSELSLMGPTVH 1431
Cdd:pfam05483  662 EIEDKKISEEKLL------EEVEKAKAIADEAVKLQKEIDKRCQHKIaemvalmekhkHQYDKIIEERDSELGLYKNKEQ 735

                          410       420
                   ....*....|....*....|
gi 392355279  1432 EMSDLpPGSLHTELSCLQAE 1451
Cdd:pfam05483  736 EQSSA-KAALEIELSNIKAE 754
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1057-1415 2.70e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 50.05  E-value: 2.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1057 SKQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRLALELHTAEglLEGFKVEKADLQEALGKKEES 1136
Cdd:TIGR00606  446 KEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEKNSLTETLKKE--VKSLQNEKADLDRKLRKLDQE 523

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1137 EQQL-----------------IVELEDLRKQLQQASRELLTL------KEENSVLWNQKETFTNEAKEREAALQKEVESL 1193
Cdd:TIGR00606  524 MEQLnhhtttrtqmemltkdkMDKDEQIRKIKSRHSDELTSLlgyfpnKKQLEDWLHSKSKEINQTRDRLAKLNKELASL 603

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1194 TRDQWESRKQSEKDRATLLSqmrvleseLEDQLVQHRGC-------AQLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAE 1266
Cdd:TIGR00606  604 EQNKNHINNELESKEEQLSS--------YEDKLFDVCGSqdeesdlERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDE 675

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1267 RE------HEREEFQQEIKWLEGQLRQATRPRPpgprdsqcakldEEVELLQEKLREKLDGFNELVIKKDLADQQLLIQE 1340
Cdd:TIGR00606  676 NQsccpvcQRVFQTEAELQEFISDLQSKLRLAP------------DKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKE 743

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392355279  1341 EEIKHLEETNENIQRQMAQLQEELEKQRRsteELEVVNSRNSEIEELK---AIIEHLQENQEQLQKAKAEEIEQLHEV 1415
Cdd:TIGR00606  744 KEIPELRNKLQKVNRDIQRLKNDIEEQET---LLGTIMPEEESAKVCLtdvTIMERFQMELKDVERKIAQQAAKLQGS 818
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1065-1399 3.18e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 49.74  E-value: 3.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1065 QLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEES---EQQLI 1141
Cdd:pfam17380  292 KFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRELErirQEEIA 371

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1142 VELEDLRkqlqQASRELLTLKEENSVLWNQKETfTNEAKEREAALQKEVESLTRDQWESRKQSEKDRATllsQMRVLESE 1221
Cdd:pfam17380  372 MEISRMR----ELERLQMERQQKNERVRQELEA-ARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQR---EVRRLEEE 443

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1222 LEDQLVQHRgcaqlaEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQATRprppgprdsqc 1301
Cdd:pfam17380  444 RAREMERVR------LEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQ----------- 506

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1302 akldeevELLQEKLREKLdgfnelvIKKDLADQQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELEVVNSRN 1381
Cdd:pfam17380  507 -------AMIEEERKRKL-------LEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEERSRLEAME 572

                          330
                   ....*....|....*...
gi 392355279  1382 SEIEELKAIIEHLQENQE 1399
Cdd:pfam17380  573 REREMMRQIVESEKARAE 590
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 234-534 3.28e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 49.63  E-value: 3.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  234 ETLRKELSAKHQSEMEGLQNQFQKELSEQKaelekifqaKHEAEVSLKNLEAQHQAAIRKlQEDLRSEHCQYLQDLELRF 313
Cdd:NF033838  109 EKSEAELTSKTKKELDAAFEQFKKDTLEPG---------KKVAEATKKVEEAEKKAKDQK-EEDRRNYPTNTYKTLELEI 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  314 REKE-KAKELELETLQAsyEDLKAQSQEEIRHLWSQLESMKtnreeqngswepllAQASHLEELQHLRsdfaqqqqqERA 392
Cdd:NF033838  179 AESDvEVKKAELELVKE--EAKEPRDEEKIKQAKAKVESKK--------------AEATRLEKIKTDR---------EKA 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  393 QHESEL---EHLRVYFEKKLNDAEKTYQEDLTVFQQRLQEAREESLESAEISSSCMFPEETsgrerkePPDPlDLQLEQP 469
Cdd:NF033838  234 EEEAKRradAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSVGEET-------LPSP-SLKPEKK 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  470 KAQGS-LIEDYQEKLSNAEEK--------------IELMKQEFQKKEAEWELSREDLKRDA-EEKLAsmflELREKAESE 533
Cdd:NF033838  306 VAEAEkKVEEAKKKAKDQKEEdrrnyptntyktleLEIAESDVKVKEAELELVKEEAKEPRnEEKIK----QAKAKVESK 381


                  .
gi 392355279  534 K 534
Cdd:NF033838  382 K 382
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 120-796 3.30e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 49.58  E-value: 3.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   120 LELEALRLSLNNMHTAQLELTQANLQKEKETALTELREMLngrraQELALLQSRQQCELELMREQHAREKEEMALRNEQE 199
Cdd:TIGR00618  196 AELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREAL-----QQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIE 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   200 TAELKEKFRSEMEKtvqmmetlkqdwesERELCLETLRKELSAKHQSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEVS 279
Cdd:TIGR00618  271 ELRAQEAVLEETQE--------------RINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQ 336

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   280 LKNLEAQHQAAIRKLQEDLRSEHCQYLQDLELRFREKEKAKELELETLQASYEDLKAQSQeEIRHLWSQLESMKTNREEQ 359
Cdd:TIGR00618  337 QSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQ-SLCKELDILQREQATIDTR 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   360 NGSWEPL---LAQASHLEELQHLRSDFAQQQQQERAQHESELEHLRVYFEKKLNdaEKTYQEDlTVFQQRLQEAREESLE 436
Cdd:TIGR00618  416 TSAFRDLqgqLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLK--EREQQLQ-TKEQIHLQETRKKAVV 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   437 SAEISSSCMFPEETSGRERKEPPDPLDLQLEQPKAQGSL-IEDYQEKLSNAEEKIELMKQEFQKKEAEWElSREDLKRDA 515
Cdd:TIGR00618  493 LARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQrGEQTYAQLETSEEDVYHQLTSERKQRASLK-EQMQEIQQS 571

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   516 EEKLASMFLELREkaeseklsIINRFELRESSMRHLQDQQaaqiSDLERSLR-EQQGHLRQLEQELTRDEVLLC-SQCGK 593
Cdd:TIGR00618  572 FSILTQCDNRSKE--------DIPNLQNITVRLQDLTEKL----SEAEDMLAcEQHALLRKLQPEQDLQDVRLHlQQCSQ 639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   594 EPSVAQDEKSAI---LLREKEDCALQLLTAQNRFLEERKEIMEKFAKEQDAFLLDTQE--KHSHELQLLQQGHQQQLLAL 668
Cdd:TIGR00618  640 ELALKLTALHALqltLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEmlAQCQTLLRELETHIEEYDRE 719

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   669 RMELETKHHSELTEQLASLESKQQALLE-THVAKMQVKHDAEISALEKRHLSNLDELESCYVADIQTIrdEHKKALELLR 747
Cdd:TIGR00618  720 FNEIENASSSLGSDLAAREDALNQSLKElMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEI--QFFNRLREED 797

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*....
gi 392355279   748 AELEEQLQKKDSCHREILTQELEKLKLKHAEELQSVRNSLRVKMSAQHT 796
Cdd:TIGR00618  798 THLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLGE 846
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1064-1501 3.39e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 49.38  E-value: 3.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1064 RQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRLA---LELHTAEGLLEGFKVEKADLQEALGKKEESEQ-- 1138
Cdd:COG4717    49 ERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAelqEELEELEEELEELEAELEELREELEKLEKLLQll 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1139 QLIVELEDLRKQLQQASRELLTLKEENSV---LWNQKETFTNEAKEREAALQKEVESLTRDQWESRKQSEKDRATLLSQM 1215
Cdd:COG4717   129 PLYQELEALEAELAELPERLEELEERLEElreLEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRL 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1216 RVLESELEdqlvqhrgcaQLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQATRPRPPG 1295
Cdd:COG4717   209 AELEEELE----------EAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGV 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1296 PRDSQCAKLDEEVELLQEK--LREKLDGFNELVIKKDLADQQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEE 1373
Cdd:COG4717   279 LFLVLGLLALLFLLLAREKasLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEE 358

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1374 LEVVNSRNSEIEELKAIIEHLQ-ENQEQLQKA--KAEEIEQLHEVIEKLQSELSLMGPTVHE-MSDLPPGSLHTELSCLQ 1449
Cdd:COG4717   359 LEEELQLEELEQEIAALLAEAGvEDEEELRAAleQAEEYQELKEELEELEEQLEELLGELEElLEALDEEELEEELEELE 438

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 392355279 1450 AEgmgGQALHNELQAAQAAKGAFGQLLADHGHSQALEALQERLQDAEAAAAR 1501
Cdd:COG4717   439 EE---LEELEEELEELREELAELEAELEQLEEDGELAELLQELEELKAELRE 487
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1328-1550 3.41e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 3.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1328 KKDLADQQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELE-VVNSRNSEIEELKAIIEHLQENQEQLQKAKA 1406
Cdd:COG4942    21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALArRIRALEQELAALEAELAELEKEIAELRAELE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1407 EEIEQLHEVIEKLQselsLMGPTVHEMSDLPPGSLHTELSCLQAEGMGGQALHNELQAAQAAKGAFGQLladhghSQALE 1486
Cdd:COG4942   101 AQKEELAELLRALY----RLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAAL------RAELE 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392355279 1487 ALQERLQDAEAAAARHLTELEHCVALRQAEVEAMASRIQEFEATLKAKEAIIVQRDLEIDAVNK 1550
Cdd:COG4942   171 AERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEA 234
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1116-1421 4.48e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 49.25  E-value: 4.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1116 LEGFKVEKADLQEALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEENSVLWNQKETFTNEakerEAALQKEVESLTR 1195
Cdd:TIGR04523  386 IKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQ----DSVKELIIKNLDN 461

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1196 dqweSRKQSEKDRATLLSQMRVLESELEdqlvqhrgcaQLAEEVTTLKQQLatldKHLRSQRQFMDEQAAEREHEREEFQ 1275
Cdd:TIGR04523  462 ----TRESLETQLKVLSRSINKIKQNLE----------QKQKELKSKEKEL----KKLNEEKKELEEKVKDLTKKISSLK 523

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1276 QEIKWLEgqlrqatrprppgprdSQCAKLDEEVELLQEKLREKLDGFNELVIKKDLADQQlliqeEEIKHLEETNENIQR 1355
Cdd:TIGR04523  524 EKIEKLE----------------SEKKEKESKISDLEDELNKDDFELKKENLEKEIDEKN-----KEIEELKQTQKSLKK 582

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392355279  1356 QMAQLQEELEKQRRSTEELevvnsrNSEIEELKAIIEHLqenQEQLQKAKAEEiEQLHEVIEKLQS 1421
Cdd:TIGR04523  583 KQEEKQELIDQKEKEKKDL------IKEIEEKEKKISSL---EKELEKAKKEN-EKLSSIIKNIKS 638
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 168-507 4.54e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 48.97  E-value: 4.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   168 ALLQSRQQCELELMREQHAR-EKEEMA--LRNEQETAELKEKFRSEMEKTVQM-METLKQDWESERELclETLRKElsaK 243
Cdd:pfam17380  283 AVSERQQQEKFEKMEQERLRqEKEEKAreVERRRKLEEAEKARQAEMDRQAAIyAEQERMAMEREREL--ERIRQE---E 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   244 HQSEMEGLQNQFQKELSEQKAELEKI-FQAKHEAEVSLKNLEAQHQAAIrkLQEDLRSEHCQYLQDLELRFREKEKAKEL 322
Cdd:pfam17380  358 RKRELERIRQEEIAMEISRMRELERLqMERQQKNERVRQELEAARKVKI--LEEERQRKIQQQKVEMEQIRAEQEEARQR 435

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   323 ELETLQASYEDLKAQSQEEIRHLWSQLESMKTNREEQNGSWEPLLAQASHLEELQHLRSDFAQQQQQERAQHESELEHLR 402
Cdd:pfam17380  436 EVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKR 515

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   403 VYFEKKLNDAEKTYQEdltvfQQRLQEAREESLESAEIssscmfpeetsgRERKeppdpldlqleQPKAQGSLIEDYQEK 482
Cdd:pfam17380  516 KLLEKEMEERQKAIYE-----EERRREAEEERRKQQEM------------EERR-----------RIQEQMRKATEERSR 567

                          330       340
                   ....*....|....*....|....*..
gi 392355279   483 LSNAEEKIELMKQ--EFQKKEAEWELS 507
Cdd:pfam17380  568 LEAMEREREMMRQivESEKARAEYEAT 594
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 201-544 4.61e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 49.20  E-value: 4.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   201 AELKEKFRSEMEKTVQMMETLKQDWESERELCLETLRKELSAKhqSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEVSL 280
Cdd:pfam02463  165 SRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAK--KALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   281 KNLEAQHQAAIRKLQEDLRSEhcQYLQDLELRFREKEKAKELELETLQASYEDLKAQSQEEIRHLWSQLESmktNREEQN 360
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKE--EEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVD---DEEKLK 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   361 GSWEPLLAQASHLEELQHLRSDFAQQQQQERAQHESELEhlRVYFEKKLNDAEKTYQEDLTVFQQRLQEAREESLESAEI 440
Cdd:pfam02463  318 ESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEE--EEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEE 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   441 SSSCMFPEETSGRERKEPPDPLDLQLEQPKAQGSLIEDYQEKLSNAEEKIELMKQEFQKKEAEWELSREDLKRDAEEKLA 520
Cdd:pfam02463  396 ELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLK 475

                          330       340
                   ....*....|....*....|....
gi 392355279   521 SMFLELREKAESEKLSIINRFELR 544
Cdd:pfam02463  476 ETQLVKLQEQLELLLSRQKLEERS 499
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 178-964 5.14e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 48.96  E-value: 5.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   178 LELMREQHAREKEEMAlRNEQETAELKEKFRSEMEKTVQMMETLKQDWESERELCLETLRKElsakHQSEmEGLQNQFQK 257
Cdd:pfam15921   76 IERVLEEYSHQVKDLQ-RRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRE----SQSQ-EDLRNQLQN 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   258 ELseqkaelekifqakHEAEvslknleaqhqaAIRKLQEDLRSEHCQYLQDLelrfREKEKAKELELETLQASYEDLKAQ 337
Cdd:pfam15921  150 TV--------------HELE------------AAKCLKEDMLEDSNTQIEQL----RKMMLSHEGVLQEIRSILVDFEEA 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   338 SQEEIRhlwsQLESMKTNREEQNGSwepllAQASHLEELqhlrsdfaqqqqqeraqhESELEHL--RVY-FEKKLNDAEK 414
Cdd:pfam15921  200 SGKKIY----EHDSMSTMHFRSLGS-----AISKILREL------------------DTEISYLkgRIFpVEDQLEALKS 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   415 TYQEDLTVFQQRLQEAREESLESAEISSSCMFPEETSGRERKEP-PDPLDLQLEQPKAQGSLiedYQEKLSNAEEKIELM 493
Cdd:pfam15921  253 ESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSiQSQLEIIQEQARNQNSM---YMRQLSDLESTVSQL 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   494 KQEFQKKEAEWELSREDLkrdaEEKLASMFLELRE-KAESEKLSiinrfelRESSmrHLQDQQAAQISDL-----ERSLR 567
Cdd:pfam15921  330 RSELREAKRMYEDKIEEL----EKQLVLANSELTEaRTERDQFS-------QESG--NLDDQLQKLLADLhkrekELSLE 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   568 EQQG---------------HLRQ----LEQELTRDEVLLCSQCGKEPSVAQDEKSAILLREKEDCALQLLTAQnrfLEER 628
Cdd:pfam15921  397 KEQNkrlwdrdtgnsitidHLRRelddRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQ---LEST 473

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   629 KEIMEKFAKEQDAflldtqekhshelqllqqghqqqllaLRMELETKHHSeLTEQLASLESKQQALLETHVAKMQVKHDA 708
Cdd:pfam15921  474 KEMLRKVVEELTA--------------------------KKMTLESSERT-VSDLTASLQEKERAIEATNAEITKLRSRV 526

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   709 EISALEKRHLSNldelescyvadiqtiRDEHKKALELLRAELEEQLQKKDSChREILTQELEKLklkhaeelqsvrnslr 788
Cdd:pfam15921  527 DLKLQELQHLKN---------------EGDHLRNVQTECEALKLQMAEKDKV-IEILRQQIENM---------------- 574

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   789 VKMSAQHTESgkgpaadlqgahqkapAMALHNEGHQLEED-GDAALGGADTEDLQHHAEPREREgphtVEMQTSQTELAK 867
Cdd:pfam15921  575 TQLVGQHGRT----------------AGAMQVEKAQLEKEiNDRRLELQEFKILKDKKDAKIRE----LEARVSDLELEK 634

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   868 PQELQASQDQGAQVRD---QVFLLSRELEECRGELEQLQQRRE-------RENQEGATLICMLRADVDLAQSEGKALRDA 937
Cdd:pfam15921  635 VKLVNAGSERLRAVKDikqERDQLLNEVKTSRNELNSLSEDYEvlkrnfrNKSEEMETTTNKLKMQLKSAQSELEQTRNT 714

                          810       820
                   ....*....|....*....|....*..
gi 392355279   938 LRRLLDLFGETLKAAVTLKSRISERAG 964
Cdd:pfam15921  715 LKSMEGSDGHAMKVAMGMQKQITAKRG 741
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 121-357 6.88e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 48.58  E-value: 6.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   121 ELEALRLSLNNMHTAQLELTQANLQKEKETALTEL---REMLNGRRAQELALLQSRQQCELELMREQHAREKEEMALRNE 197
Cdd:pfam17380  349 ELERIRQEERKRELERIRQEEIAMEISRMRELERLqmeRQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAE 428

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   198 QETAELKEKFRSEMEKTVQmMETLKQDwESERELCLETLRKELSAKHQSEMEGLQNQFQKELSEQKAE--LEKIFQAKHE 275
Cdd:pfam17380  429 QEEARQREVRRLEEERARE-MERVRLE-EQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRkiLEKELEERKQ 506

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   276 AEVSLKNLEaqhqaaiRKLQEDLRSEHCQYLQDLELRFREKEKAKELELETLQASYEDLKAQSQEEirhlwSQLESMKTN 355
Cdd:pfam17380  507 AMIEEERKR-------KLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEER-----SRLEAMERE 574


                   ..
gi 392355279   356 RE 357
Cdd:pfam17380  575 RE 576
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 128-563 7.45e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 48.58  E-value: 7.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   128 SLNNMHTAQLELTQANLQKEKETALTELREMLNGRRAQeLALLQSRQQCELELMREQHAREKEEMALRNEQETAELKEKF 207
Cdd:pfam15921  209 SMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQ-LEALKSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKA 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   208 RSEMEKTVQMMETLKQDWESERElcletlRKELSAKHQSEMEGLQNQFQKELSEqkaelekifqAKHEAEVSLKNLEAQH 287
Cdd:pfam15921  288 SSARSQANSIQSQLEIIQEQARN------QNSMYMRQLSDLESTVSQLRSELRE----------AKRMYEDKIEELEKQL 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   288 QAAIRKLQEdLRSEHCQY----------LQDLELRFREKEKAKELELETLQASYeDLKAQSQEEIRHLWSQLES------ 351
Cdd:pfam15921  352 VLANSELTE-ARTERDQFsqesgnlddqLQKLLADLHKREKELSLEKEQNKRLW-DRDTGNSITIDHLRRELDDrnmevq 429

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   352 -----MKTNREEQNGSWEPLLAQASHLEELQHLRSDFAqqqqqerAQHESELEHLRVYFEK------KLNDAEKTYQeDL 420
Cdd:pfam15921  430 rlealLKAMKSECQGQMERQMAAIQGKNESLEKVSSLT-------AQLESTKEMLRKVVEEltakkmTLESSERTVS-DL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   421 TVFQQRLQEAREESleSAEIssscmfpeeTSGRERkeppdpLDLQLEQPKAqgslIEDYQEKLSNAEEKIELMKQEFQKK 500
Cdd:pfam15921  502 TASLQEKERAIEAT--NAEI---------TKLRSR------VDLKLQELQH----LKNEGDHLRNVQTECEALKLQMAEK 560

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392355279   501 EAEWELSR---EDLKRDAEEKLASMFLELREKAESEKLSIINRFELREssMRHLQDQQAAQISDLE 563
Cdd:pfam15921  561 DKVIEILRqqiENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQE--FKILKDKKDAKIRELE 624
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
146-542 1.07e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 48.14  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  146 KEKETALTELREMLNG--RRAQELALLQSR-QQCELELMREQHAREKEEMALRNEQETAELKEKFRSEMEKTVQMMETLK 222
Cdd:PRK03918  210 NEISSELPELREELEKleKEVKELEELKEEiEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELK 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  223 QDWESEREL--CLETLRKELS------AKHQSEMEGLQNQFqKELSEQKAELEKIFQAKHEAEVSLKNLEAQHQA--AIR 292
Cdd:PRK03918  290 EKAEEYIKLseFYEEYLDELReiekrlSRLEEEINGIEERI-KELEEKEERLEELKKKLKELEKRLEELEERHELyeEAK 368

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  293 KLQEDLRsehcqylqdlelrfREKEKAKELELETLQASYEDL---KAQSQEEIRHLWSQLESMKTNREEQNGSwepllaq 369
Cdd:PRK03918  369 AKKEELE--------------RLKKRLTGLTPEKLEKELEELekaKEEIEEEISKITARIGELKKEIKELKKA------- 427

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  370 ashLEELQHLRSDFAQQQQQERAQHESELehLRVYfEKKLNDAEKTYQEdltvFQQRLQEAREE--SLESAEISSSCMFP 447
Cdd:PRK03918  428 ---IEELKKAKGKCPVCGRELTEEHRKEL--LEEY-TAELKRIEKELKE----IEEKERKLRKElrELEKVLKKESELIK 497

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  448 EETSGRERKEppdpldlqleqpkAQGSLIEDYQEKLSNAEEKIELMKQEFQKKEAEWELSREDLKR--DAEEKLASMFLE 525
Cdd:PRK03918  498 LKELAEQLKE-------------LEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKleELKKKLAELEKK 564

                         410
                  ....*....|....*..
gi 392355279  526 LREkAESEKLSIINRFE 542
Cdd:PRK03918  565 LDE-LEEELAELLKELE 580
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1119-1538 1.13e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 48.14  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1119 FKVEKADLQEALGKKEESEQQLIVELEDLRKQLQQASRElltlkeensvlwnqketftNEAKEREAALQKEVESltRDQW 1198
Cdd:TIGR02169  168 FDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRRE-------------------REKAERYQALLKEKRE--YEGY 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1199 E---SRKQSEKDRATLLSQMRVLESELEDQLVQhrgCAQLAEEVTTLKQQLATLDKHLRSQRQfmDEQAAerehereeFQ 1275
Cdd:TIGR02169  227 EllkEKEALERQKEAIERQLASLEEELEKLTEE---ISELEKRLEEIEQLLEELNKKIKDLGE--EEQLR--------VK 293

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1276 QEIKWLEGQLRQAtrprppgprDSQCAKLDEEVELLQEKLREkldgfnelvikkdlADQQLLIQEEEIKHLEETNENIQR 1355
Cdd:TIGR02169  294 EKIGELEAEIASL---------ERSIAEKERELEDAEERLAK--------------LEAEIDKLLAEIEELEREIEEERK 350

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1356 QMAQLQEELEKQRRSTEELEvvnsrnSEIEELKAIIEHLQENQEQLQkakaEEIEQLHEVIEKLQSELSLMGPTVHEmsd 1435
Cdd:TIGR02169  351 RRDKLTEEYAELKEELEDLR------AELEEVDKEFAETRDELKDYR----EKLEKLKREINELKRELDRLQEELQR--- 417

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1436 lppgsLHTELSCLQAEGMGGQALHNELQAAQAAKGA--------FGQLLADHG-HSQALEALQERLQDAEaaaaRHLTEL 1506
Cdd:TIGR02169  418 -----LSEELADLNAAIAGIEAKINELEEEKEDKALeikkqewkLEQLAADLSkYEQELYDLKEEYDRVE----KELSKL 488

                          410       420       430
                   ....*....|....*....|....*....|..
gi 392355279  1507 EHCVALRQAEVEAMASRIQEFEATLKAKEAII 1538
Cdd:TIGR02169  489 QRELAEAEAQARASEERVRGGRAVEEVLKASI 520
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 2063-2448 1.30e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 47.76  E-value: 1.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2063 RPYSSDLGDYNSLVKKLEKVIQEQGDLQKVREhACLPDRSSLLAEIQALRAQLRMTHLQNQEKLQQLcAALTSTEARGSQ 2142
Cdd:TIGR02169  660 RAPRGGILFSRSEPAELQRLRERLEGLKRELS-SLQSELRRIENRLDELSQELSDASRKIGEIEKEI-EQLEQEEEKLKE 737

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2143 REHQLRR-----QVELLAYKVEQEKCIAN--DLQKTLSKEQEAASDVRKRLMVEQ-GAVQDLKSELHACKQENTNLLESL 2214
Cdd:TIGR02169  738 RLEELEEdlsslEQEIENVKSELKELEARieELEEDLHKLEEALNDLEARLSHSRiPEIQAELSKLEEEVSRIEARLREI 817

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2215 DKVQQEVLRLRAVLDGKENELKVVLEELECERgkgqvlqaqqeeqqlRHLQREGQSSRA-LEELKISLEKQLAQNNQLCV 2293
Cdd:TIGR02169  818 EQKLNRLTLEKEYLEKEIQELQEQRIDLKEQI---------------KSIEKEIENLNGkKEELEEELEELEAALRDLES 882

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2294 ALKHERAAKDNLQKELQieasrceallaQEKGQLSELRKSLEAERSRSLELSEALQherLLTEQLSRNAQEACARQDTQA 2373
Cdd:TIGR02169  883 RLGDLKKERDELEAQLR-----------ELERKIEELEAQIEKKRKRLSELKAKLE---ALEEELSEIEDPKGEDEEIPE 948

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392355279  2374 QHALLRKLKAEKARALELEAMLEKVQKQAahtqQQLEAQAQERCLELrREKERELELQRQRDEHKIEQLQRLVRE 2448
Cdd:TIGR02169  949 EELSLEDVQAELQRVEEEIRALEPVNMLA----IQEYEEVLKRLDEL-KEKRAKLEEERKAILERIEEYEKKKRE 1018
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1120-1424 1.40e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 47.32  E-value: 1.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1120 KVEKADLQEALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEENSVLWNQKETFTNE----AKEREAALQKEVESLTR 1195
Cdd:TIGR04523  238 QQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEisdlNNQKEQDWNKELKSELK 317

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1196 DQWESRKQSEKDratlLSQMRVLESELEDQLvqhrgcAQLAEEVTTLKQQLATLDKHLR---SQRQFMDEQAAEREHERE 1272
Cdd:TIGR04523  318 NQEKKLEEIQNQ----ISQNNKIISQLNEQI------SQLKKELTNSESENSEKQRELEekqNEIEKLKKENQSYKQEIK 387

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1273 EFQQEIKWLEGQLRQAtrprppgprDSQCAKLDEEVELLQ---EKLREKLDGFNELVIK-----KDLADQQLlIQEEEIK 1344
Cdd:TIGR04523  388 NLESQINDLESKIQNQ---------EKLNQQKDEQIKKLQqekELLEKEIERLKETIIKnnseiKDLTNQDS-VKELIIK 457

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1345 HLEETNENIQRQMAQLQEELEKQRRSTEELEV-VNSRNSEIEELKAIIEHLQENQEQLQKAKAE---EIEQLHEVIEKLQ 1420
Cdd:TIGR04523  458 NLDNTRESLETQLKVLSRSINKIKQNLEQKQKeLKSKEKELKKLNEEKKELEEKVKDLTKKISSlkeKIEKLESEKKEKE 537


                   ....
gi 392355279  1421 SELS 1424
Cdd:TIGR04523  538 SKIS 541
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 508-1158 1.45e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 47.62  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  508 REDLKRDAEekLASMFLELREKAE----SEKLSIINRFELRESSMRHLQDQQAAQISDLERSLREQQGHLRQLEQELTRD 583
Cdd:COG1196   202 LEPLERQAE--KAERYRELKEELKeleaELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEEL 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  584 EVLLcsqcgkepsVAQDEKSAILLREKEDC--ALQLLTAQNRFLEERKEIMEKFAKEQDAFLLDTQEKhshelqllqqgh 661
Cdd:COG1196   280 ELEL---------EEAQAEEYELLAELARLeqDIARLEERRRELEERLEELEEELAELEEELEELEEE------------ 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  662 qqqLLALRMELEtkhhsELTEQLASLESKQQALLEthvakmqvkhdaEISALEKRHLSNLDELESCYVADIQTIRDEHKK 741
Cdd:COG1196   339 ---LEELEEELE-----EAEEELEEAEAELAEAEE------------ALLEAEAELAEAEEELEELAEELLEALRAAAEL 398

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  742 ALELLRAELEEQLQKKDschREILTQELEKLKLKHAEELQSVRNSLRVKMSAQHTESgkgpAADLQGAHQKAPAMALHNE 821
Cdd:COG1196   399 AAQLEELEEAEEALLER---LERLEEELEELEEALAELEEEEEEEEEALEEAAEEEA----ELEEEEEALLELLAELLEE 471

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  822 GHQLEEDGDAALGGADTEDLQHHAEPREREGPHtvEMQTSQTELAKPQELQASQDQGAQVRDQVFLLSRELEECRGELEQ 901
Cdd:COG1196   472 AALLEAALAELLEELAEAAARLLLLLEAEADYE--GFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQ 549

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  902 LQQRRERENQEGAtlicmlrADVDLAQSEGKALRDALRRLLDLFGETLKAAVTLKSRISERAGLLLDHEDAVDTSGAQLA 981
Cdd:COG1196   550 NIVVEDDEVAAAA-------IEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTL 622

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  982 AAALGEMWPDEGLLDIDRTLPEGAETSSvceisshvcesffmspentqeceQPIRKVYQSLSTAVEGLLDMALDSSKQLE 1061
Cdd:COG1196   623 LGRTLVAARLEAALRRAVTLAGRLREVT-----------------------LEGEGGSAGGSLTGGSRRELLAALLEAEA 679

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1062 DARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEESEQQLI 1141
Cdd:COG1196   680 ELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEP 759

                         650
                  ....*....|....*..
gi 392355279 1142 VELEDLRKQLQQASREL 1158
Cdd:COG1196   760 PDLEELERELERLEREI 776
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1096-1426 1.46e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 47.73  E-value: 1.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1096 REESAAKDRLA---LELHTAEGLLEGFKVEKADLQEALGKKEE------SEQQLIVELEDLRKQLQQASRELLTLKEENS 1166
Cdd:TIGR00606  584 KEINQTRDRLAklnKELASLEQNKNHINNELESKEEQLSSYEDklfdvcGSQDEESDLERLKEEIEKSSKQRAMLAGATA 663

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1167 VLWNQKETFTNEAK------EREAALQKEVESLTRDQWESRKQSEKDRATLLSQMRVLESELEDQLVQHRGCAQLAE--- 1237
Cdd:TIGR00606  664 VYSQFITQLTDENQsccpvcQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDlke 743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1238 -EVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQE---------IKWLEGQLRQATRPRPPGPRDSQCAKLDEE 1307
Cdd:TIGR00606  744 kEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAkvcltdvtiMERFQMELKDVERKIAQQAAKLQGSDLDRT 823

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1308 VELLQEKLREKLDGFNELVIKKDLADQQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELEV----VNSRNSE 1383
Cdd:TIGR00606  824 VQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVElsteVQSLIRE 903

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 392355279  1384 IEELKAIIEHLQENQEQLQKAKAEEIEQLHEVIEKLQSELSLM 1426
Cdd:TIGR00606  904 IKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDI 946
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2146-2449 1.53e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.74  E-value: 1.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2146 QLRRQVELLAYKVEQEKCIANDLQKTLSKEQEAASDVRKRLMVEQGAVQDLKSELHACKQENTNLLESLDKVQQEVLRLR 2225
Cdd:TIGR02168  681 ELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELE 760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2226 AVLDGKENELKVVLEELECERGKGQVLQAQQEEQQLRHLQREGQSSRALEELkiSLEKQLAQNNQLCVALKHERAAkdnl 2305
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAEL--TLLNEEAANLRERLESLERRIA---- 834

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  2306 qkELQIEASRCEALLAQEKGQLSELRKSLEAERSRSLELSEALQHERLLTEQLSRNAQEACARQDTQA--QHALLRKLKA 2383
Cdd:TIGR02168  835 --ATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSeeLRELESKRSE 912

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392355279  2384 EKARALELEAMLEKVQ------KQAAHTQQQLEAQAQERCLELRREKERELELQRQRDEHKIEQLQRLVREL 2449
Cdd:TIGR02168  913 LRRELEELREKLAQLElrleglEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKEL 984
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1332-1547 1.76e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.75  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1332 ADQQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELEVvnsrnsEIEELKAIIEHLQENQEQLQKAKAEEIEQ 1411
Cdd:COG3883    14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQA------ELEALQAEIDKLQAEIAEAEAEIEERREE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1412 LHEVIEKLQSELSLMGPTVHEMSDLPPGSLHTELSCLQAEGMGGQALHNELQAAQAAKGAFGQLLADHGhsQALEALQER 1491
Cdd:COG3883    88 LGERARALYRSGGSVSYLDVLLGSESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKL--AELEALKAE 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 392355279 1492 LQDAEAAAARHLTELEHCVALRQAEVEAMASRIQEFEATLKAKEAIIVQRDLEIDA 1547
Cdd:COG3883   166 LEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 679-1249 1.91e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 47.24  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  679 ELTEQLASLESKQQALLETHVAKMQVKHDAEISALEKRHLSNLDELESCyVADIQTIRDEHKKALELLRAELEEQLQKKD 758
Cdd:COG1196   217 ELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAEL-EAELEELRLELEELELELEEAQAEEYELLA 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  759 SCHREILTQELEKLKLKHAEE-LQSVRNSLRVKMSAQHTESGKGPAADLQGAHQKAPAMALHNEGHQLEEDGDAALGGAD 837
Cdd:COG1196   296 ELARLEQDIARLEERRRELEErLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELA 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  838 TEDLQHHAEPREREgphtvEMQTSQTELAKPQELQASQDQGAQVRDQvfllsrELEECRGELEQLQQRRERENQEGATLI 917
Cdd:COG1196   376 EAEEELEELAEELL-----EALRAAAELAAQLEELEEAEEALLERLE------RLEEELEELEEALAELEEEEEEEEEAL 444

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  918 CMLRADVDLAQSEGKALRDALRRLLDLFGETLKAAVTLKSRISERAGLLLDHEDAVDT----SGAQLAAAALGEMWPDEG 993
Cdd:COG1196   445 EEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADyegfLEGVKAALLLAGLRGLAG 524

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  994 LLDIDRTLPEGAETSSVCEISSHVCESFFmspENTQECEQPIRKVYQSLSTAVEGLLDMALDSSKQLEDARQLHRcVEKE 1073
Cdd:COG1196   525 AVAVLIGVEAAYEAALEAALAAALQNIVV---EDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGA-IGAA 600

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1074 FRHRDEEMAQAVQKQQELLERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEESEQQLIVELEDLRKQLQQ 1153
Cdd:COG1196   601 VDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAE 680

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1154 ASRELLTLKEENSVLWNQKETFTNEAKEREAALQKEVESLTRDQwESRKQSEKDRATLLSQMRVLESELEDQLVQHRGC- 1232
Cdd:COG1196   681 LEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEE-ALEEQLEAEREELLEELLEEEELLEEEALEELPEp 759

                         570       580
                  ....*....|....*....|
gi 392355279 1233 ---AQLAEEVTTLKQQLATL 1249
Cdd:COG1196   760 pdlEELERELERLEREIEAL 779
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1088-1422 2.03e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 46.81  E-value: 2.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1088 QQELLERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEENSV 1167
Cdd:pfam07888   40 LQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDA 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1168 LWNQKE--------------TFTNEAKEREAAL------QKEVESLTRDQWESRKQSEKDRATLLSQMRVLESELED--- 1224
Cdd:pfam07888  120 LLAQRAahearireleedikTLTQRVLERETELermkerAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQElrn 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1225 -QLVQHRGCAQLAEEVTTLKQQLATLDKHlRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQATRPRPPGPRDSQCAK 1303
Cdd:pfam07888  200 sLAQRDTQVLQLQDTITTLTQKLTTAHRK-EAENEALLEELRSLQERLNASERKVEGLGEELSSMAAQRDRTQAELHQAR 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1304 LdeEVELLQEKLREKldgfnELVIKKDLA----DQQLLIQEEEIKH--LEETNENIQRQMAQLQEE-LEKQRRSTE---- 1372
Cdd:pfam07888  279 L--QAAQLTLQLADA-----SLALREGRArwaqERETLQQSAEADKdrIEKLSAELQRLEERLQEErMEREKLEVElgre 351

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 392355279  1373 ---ELEVVNSRNSEIEELKAIIEHLQENQEQLQKAKAEEIEQLHEVIEKLQSE 1422
Cdd:pfam07888  352 kdcNRVQLSESRRELQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQRLETV 404
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1304-1422 2.50e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 46.77  E-value: 2.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1304 LDEEVELLQEKLREKLDGFNELVIKKDLADQQLLiqEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELE-------- 1375
Cdd:COG2433   378 IEEALEELIEKELPEEEPEAEREKEHEERELTEE--EEEIRRLEEQVERLEAEVEELEAELEEKDERIERLErelsears 455

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 392355279 1376 ----------VVNSRNSEIEELKAIIEHLQENQEQLQkakaEEIEQLHEVIEKLQSE 1422
Cdd:COG2433   456 eerreirkdrEISRLDREIERLERELEEERERIEELK----RKLERLKELWKLEHSG 508
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1328-1507 2.68e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.83  E-value: 2.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1328 KKDLADQQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELEV---VNSRNSEIEELKAIIEHLQEN------- 1397
Cdd:COG4913   611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDeidVASAEREIAELEAELERLDASsddlaal 690

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1398 QEQLQKAKAeEIEQLHEVIEKLQSELSLMGPTVHEMSDLPPgSLHTELSclQAEGMGGQALHNELQAaqaakgAFGQLLA 1477
Cdd:COG4913   691 EEQLEELEA-ELEELEEELDELKGEIGRLEKELEQAEEELD-ELQDRLE--AAEDLARLELRALLEE------RFAAALG 760

                         170       180       190
                  ....*....|....*....|....*....|
gi 392355279 1478 DHGHSQALEALQERLQDAEAAAARHLTELE 1507
Cdd:COG4913   761 DAVERELRENLEERIDALRARLNRAEEELE 790
PTZ00121 PTZ00121
MAEBL; Provisional
 2131-2454 3.52e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 3.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2131 AALTSTEARGSQREHQLRRQVELLAYKVEqEKCIANDLQKTlSKEQEAASDVRKRLMVEQGAVQDLKSELHACKQENTNL 2210
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKADEAKKKAE-EAKKADEAKKK-AEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKK 1490

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2211 LESLDKVQQEVLRLRAVLDGKENELKVVLEELECERGKGQVLQAQQEEQQLRHLQREGQSSRALEELKISLEKQLAQNNQ 2290
Cdd:PTZ00121 1491 KAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAK 1570

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2291 LCVALKHERAAKDNLQKelQIEASRCEALLA-----------------QEKGQLSELRKSlEAERSRSLELSEALQHERL 2353
Cdd:PTZ00121 1571 KAEEDKNMALRKAEEAK--KAEEARIEEVMKlyeeekkmkaeeakkaeEAKIKAEELKKA-EEEKKKVEQLKKKEAEEKK 1647

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2354 LTEQLSRNAQEACARQDTQAQHALLRKLKAEKARALELEamlekvqKQAAHTQQQLEAQAQERCLELRREKEREL----E 2429
Cdd:PTZ00121 1648 KAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEED-------EKKAAEALKKEAEEAKKAEELKKKEAEEKkkaeE 1720

                         330       340
                  ....*....|....*....|....*..
gi 392355279 2430 LQRQRDEHKI--EQLQRLVRELRWKEE 2454
Cdd:PTZ00121 1721 LKKAEEENKIkaEEAKKEAEEDKKKAE 1747
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 1026-1425 3.81e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 46.12  E-value: 3.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1026 ENTQECEQPIRKVYQSLSTAVEGLLDM--ALDSSKQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKD 1103
Cdd:TIGR00618  438 RYAELCAAAITCTAQCEKLEKIHLQESaqSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPAR 517

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1104 RLALELHTAEGLLEGFKVEKADLQEALGKKEESEQQLIVELEDLRKQLQQASRELLTLkeenSVLWNQKETFTNEAKERE 1183
Cdd:TIGR00618  518 QDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSIL----TQCDNRSKEDIPNLQNIT 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1184 AALQKEVESLTRDQWESRKQSEKDRATLLSQMRVLESELEDQLVQHRgcaqLAEEVTTLKQQLATLDK-----HLRSQRQ 1258
Cdd:TIGR00618  594 VRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQE----LALKLTALHALQLTLTQervreHALSIRV 669

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1259 FMDEQAAERehereefQQEIKWLEGQLRQATRPRPPGPRDSQCAKLDEEVELLQEKLREKldgfnelvIKKDLADQQLLI 1338
Cdd:TIGR00618  670 LPKELLASR-------QLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNE--------IENASSSLGSDL 734

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1339 QEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELEVVNSRNSEIEELKAIIEHLQENQEQLQKAKAEEIEQLHEVIEK 1418
Cdd:TIGR00618  735 AAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPS 814


                   ....*..
gi 392355279  1419 LQSELSL 1425
Cdd:TIGR00618  815 DEDILNL 821
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 1275-1424 4.38e-04

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 45.00  E-value: 4.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1275 QQEIKWLEgQLRQATRPRPPGPRDSQcakldeevELLQEKLREKLDGFNELVikkDLADQQLLIQEEEIkhLEETNENIQ 1354
Cdd:pfam01544   85 HEPLPALD-EVRKRLTLLGGGPLDPG--------DLLYRLLDEIVDRFLELL---EKLEDELDELEDEL--EDETNNELL 150

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392355279  1355 RQMAQLQEELEK-------QRRSTEELEVVNSRNSEIEELKAIIEHLQENQEQLqkakAEEIEQLHEVIEKLQSELS 1424
Cdd:pfam01544  151 RELAALRRSLVYlrrsllpQRDVLNRLLRREDDPLLDDEQKEYLRDLLDRLERL----LEDLDALRERLRSLQDEYS 223
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 1127-1419 5.73e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 45.33  E-value: 5.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1127 QEALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEENSVLWN----QKETFTNEAKEREAALQKEVESLTRDQWEsrk 1202
Cdd:COG5185   267 LEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKAteslEEQLAAAEAEQELEESKRETETGIQNLTA--- 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1203 QSEKDRATLLSQMRVLESELEdQLVQHRGCAQLAEEVTTLKQQLATLDKHL----RSQRQFMDEQAAEREHEREEFQQEI 1278
Cdd:COG5185   344 EIEQGQESLTENLEAIKEEIE-NIVGEVELSKSSEELDSFKDTIESTKESLdeipQNQRGYAQEILATLEDTLKAADRQI 422

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1279 KWLEGQLRQATRPRPPGPRdsqcaKLDEEVELLQEKLREKLDGFNELVIKKDLADQQLLIQEEEIkhLEETNENIQRQMA 1358
Cdd:COG5185   423 EELQRQIEQATSSNEEVSK-----LLNELISELNKVMREADEESQSRLEEAYDEINRSVRSKKED--LNEELTQIESRVS 495

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392355279 1359 QLQEELEKQRRSTEelEVVNSRNSEIEELKAIIEHLQENQEQLQKAKAEEIEQLHEVIEKL 1419
Cdd:COG5185   496 TLKATLEKLRAKLE--RQLEGVRSKLDQVAESLKDFMRARGYAHILALENLIPASELIQAS 554
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 2106-2381 6.39e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.75  E-value: 6.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2106 AEIQALRAQLRmthlQNQEKLQQLCAALTSTEargsQREHQLRRQVELLAYKVeqekciaNDLQKTLSKEQEAASDVRKR 2185
Cdd:COG4942    20 DAAAEAEAELE----QLQQEIAELEKELAALK----KEEKALLKQLAALERRI-------AALARRIRALEQELAALEAE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2186 LMVEQGAVQDLKSELHACKQENTNLLESLDKVqqevlrlravldGKENELKVVLeelecergkgqvlQAQQEEQQLRHLQ 2265
Cdd:COG4942    85 LAELEKEIAELRAELEAQKEELAELLRALYRL------------GRQPPLALLL-------------SPEDFLDAVRRLQ 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2266 REGQSSRALEELKISLEKQLAQNNQLCVALKHERAAKDNLQKELQIEASRCEALLAQEKGQLSELRKSLEAERSRSLELS 2345
Cdd:COG4942   140 YLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQ 219

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 392355279 2346 EALQHERLLTEQLSRNAQEACARQDTQAQHALLRKL 2381
Cdd:COG4942   220 QEAEELEALIARLEAEAAAAAERTPAAGFAALKGKL 255
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1055-1549 7.49e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.44  E-value: 7.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1055 DSSKQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKE 1134
Cdd:TIGR02169  361 ELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELE 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1135 ESEQQLIVELEDLRKQLQQASRELLTLKEEnsvLWNQKETFtNEAKEREAALQKEVESL--TRDQWESRKQSEKDRATLL 1212
Cdd:TIGR02169  441 EEKEDKALEIKKQEWKLEQLAADLSKYEQE---LYDLKEEY-DRVEKELSKLQRELAEAeaQARASEERVRGGRAVEEVL 516

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1213 SQMRVLESELEDQLVQHRGCAQLAEEVT--------------TLKQQLATLDKHLRSQRQFM------DEQAAEREHERE 1272
Cdd:TIGR02169  517 KASIQGVHGTVAQLGSVGERYATAIEVAagnrlnnvvveddaVAKEAIELLKRRKAGRATFLplnkmrDERRDLSILSED 596

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1273 --------------EFQQEIKW----------------LEGQLRQATRP--------------RPPGPRDSQCAKLDEEV 1308
Cdd:TIGR02169  597 gvigfavdlvefdpKYEPAFKYvfgdtlvvedieaarrLMGKYRMVTLEgelfeksgamtggsRAPRGGILFSRSEPAEL 676

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1309 ELLQEKLREKLDGFNELVIKKDLADQQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELEV-VNSRNSEIEEL 1387
Cdd:TIGR02169  677 QRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEdLSSLEQEIENV 756

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1388 KAIIEHLQENQEQLQKAKAEEIEQL--------HEVIEKLQSELSLMGPTVHEMS------DLPPGSLHTELSCLQAEGM 1453
Cdd:TIGR02169  757 KSELKELEARIEELEEDLHKLEEALndlearlsHSRIPEIQAELSKLEEEVSRIEarlreiEQKLNRLTLEKEYLEKEIQ 836

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1454 GGQALHNELQAAQAAKGAfgQLLADHGHSQALEALQERLQDAEAAAARHLTELEHCVALRQAEVEAMASRIQEFEATLKA 1533
Cdd:TIGR02169  837 ELQEQRIDLKEQIKSIEK--EIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEK 914

                          570
                   ....*....|....*.
gi 392355279  1534 KEAIIVQRDLEIDAVN 1549
Cdd:TIGR02169  915 KRKRLSELKAKLEALE 930
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
224-688 7.51e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 45.03  E-value: 7.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  224 DWESERELCLETLRKELSAKHQSEMEGLQNQFQKELSEQKAELEKIFQAKHEAEVSLKNLEAQHQAAIRKLQE--DLRSE 301
Cdd:PRK02224  180 RVLSDQRGSLDQLKAQIEEKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREEleTLEAE 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  302 HCQYLQDLELRFREKEKAKElELETLQASYEDLkaqsQEEIRHLWSQLESMKTNREeqngswepllAQASHLEELQhlrs 381
Cdd:PRK02224  260 IEDLRETIAETEREREELAE-EVRDLRERLEEL----EEERDDLLAEAGLDDADAE----------AVEARREELE---- 320

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  382 dfaqqqqQERAQHESELEHLRVYFEKKLNDAEkTYQEDLTVFQQRLQEAREESLESAEISSSCmfpeETSGRERKEPPDP 461
Cdd:PRK02224  321 -------DRDEELRDRLEECRVAAQAHNEEAE-SLREDADDLEERAEELREEAAELESELEEA----REAVEDRREEIEE 388

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  462 LDLQLEQPKAQgslIEDYQEKLSNAEEKIELM---KQEFQKKEAEWELSREDLKRDAEEklASMFLELREKAESEKlsii 538
Cdd:PRK02224  389 LEEEIEELRER---FGDAPVDLGNAEDFLEELreeRDELREREAELEATLRTARERVEE--AEALLEAGKCPECGQ---- 459

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  539 nrfELRESSMRHLQDQQAAQISDLERSLREQQGHLRQLEQELTRDEVLlcsqcgkepsvAQDEKSAILLREKEDCALQLL 618
Cdd:PRK02224  460 ---PVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDL-----------VEAEDRIERLEERREDLEELI 525

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  619 TAQNRFLEERKEIMEKFAKEQDAflLDTQEKHSHELQLLQQGHQQQLLALRMELETKhHSELTEQLASLE 688
Cdd:PRK02224  526 AERRETIEEKRERAEELRERAAE--LEAEAEEKREAAAEAEEEAEEAREEVAELNSK-LAELKERIESLE 592
PRK11281 PRK11281
mechanosensitive channel MscK;
1120-1374 1.05e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.90  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1120 KVEKADLQEAL---GKKEESEQqlivELEDLRKQLQQASRELLTLKEEnsvLWNQKETFTNEAKEREAAL-QKEVESLTR 1195
Cdd:PRK11281   59 KLVQQDLEQTLallDKIDRQKE----ETEQLKQQLAQAPAKLRQAQAE---LEALKDDNDEETRETLSTLsLRQLESRLA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1196 DQWESRKQSEKDRATLLSQMRVLESELEdqlvqhRGCAQLAEEVTTLkQQLATLDKHLRsqrqfmDEQAAEREHEREEFQ 1275
Cdd:PRK11281  132 QTLDQLQNAQNDLAEYNSQLVSLQTQPE------RAQAALYANSQRL-QQIRNLLKGGK------VGGKALRPSQRVLLQ 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1276 QEIKWLEGQLRQATrprppgprdsqcaKLDEEVELLQEKLREKLDgfnELVIKKDLADQQLLIQEEEI--KHLEETneni 1353
Cdd:PRK11281  199 AEQALLNAQNDLQR-------------KSLEGNTQLQDLLQKQRD---YLTARIQRLEHQLQLLQEAInsKRLTLS---- 258

                         250       260
                  ....*....|....*....|.
gi 392355279 1354 QRQMAQLQEELEKQRRSTEEL 1374
Cdd:PRK11281  259 EKTVQEAQSQDEAARIQANPL 279
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 2096-2357 1.15e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 44.66  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2096 ACLPDRSSLLAEIQALRAQlrmTHLQNQEKLQQLCAALTS-TEARGSQREHQLRRQVellaykVEQEKCIANDLQKTLSK 2174
Cdd:PRK10929   20 ATAPDEKQITQELEQAKAA---KTPAQAEIVEALQSALNWlEERKGSLERAKQYQQV------IDNFPKLSAELRQQLNN 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2175 EQEAASDVRKRLmveqgAVQDLKSELhacKQENTNLLESLDKVQQEVLRLRAVLD------GKENELKVVLEELEcergk 2248
Cdd:PRK10929   91 ERDEPRSVPPNM-----STDALEQEI---LQVSSQLLEKSRQAQQEQDRAREISDslsqlpQQQTEARRQLNEIE----- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2249 gqvlqaqqeeqqlRHLQREGQSSRALEElkislekqlAQNnqlcVALKHERAAKDNLQKELQI---------EASRCEAL 2319
Cdd:PRK10929  158 -------------RRLQTLGTPNTPLAQ---------AQL----TALQAESAALKALVDELELaqlsannrqELARLRSE 211

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 392355279 2320 LAQEK-----GQLSELRKSLEAERSRSLELseALQHERLLTEQ 2357
Cdd:PRK10929  212 LAKKRsqqldAYLQALRNQLNSQRQREAER--ALESTELLAEQ 252
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1308-1531 1.20e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 44.65  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1308 VELLQEKLREKLDGFNELVIKKDLAD---------QQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELEVVn 1378
Cdd:PRK02224  178 VERVLSDQRGSLDQLKAQIEEKEEKDlherlngleSELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETL- 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1379 srNSEIEELKAIIEHLQENQEQLqkakAEEIEQLHEVIEKLQSELSLMGPTVhEMSDLPPGSLHTELSCLQAEgmgGQAL 1458
Cdd:PRK02224  257 --EAEIEDLRETIAETEREREEL----AEEVRDLRERLEELEEERDDLLAEA-GLDDADAEAVEARREELEDR---DEEL 326

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392355279 1459 HNELQAAQAAKGAFGQLLadHGHSQALEALQERLQDAEAAAARHLTELEHC---VALRQAEVEAMASRIQEFEATL 1531
Cdd:PRK02224  327 RDRLEECRVAAQAHNEEA--ESLREDADDLEERAEELREEAAELESELEEAreaVEDRREEIEELEEEIEELRERF 400
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 188-912 1.23e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 44.57  E-value: 1.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   188 EKEEMALRNEQETAELKEKFRSEMEKTVQMMETLKQDWESERELCLETLRKELsakhqseMEGLQNQFQKELSEQKAELE 267
Cdd:TIGR00618  153 EFAQFLKAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQL-------LTLCTPCMPDTYHERKQVLE 225

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   268 KIFQAKHEAEVSLKNLEAQHQAAIRKLQEDLRSEH-CQYLQDLELRFREKEKAKELELETLQASYEDLK--------AQS 338
Cdd:TIGR00618  226 KELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQlLKQLRARIEELRAQEAVLEETQERINRARKAAPlaahikavTQI 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   339 QEEIRHLWSQLESMKTNREEQNGSWEPLLAQASHLEELQHLRSDFAQQQQQERAQHESELEhLRVYFEKKLNDAE--KTY 416
Cdd:TIGR00618  306 EQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATS-IREISCQQHTLTQhiHTL 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   417 QEDLTVFQQRLQEAREESLesaeissscmfpeetsgRERKEPPDPLDLQLEQPKAQGSLIedYQEKLSNAEEKIELMKQE 496
Cdd:TIGR00618  385 QQQKTTLTQKLQSLCKELD-----------------ILQREQATIDTRTSAFRDLQGQLA--HAKKQQELQQRYAELCAA 445

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   497 FQKKEAEWELSREDLKRDAEEKLasmflelreKAESEKLSIINRFELRESSMRHLQDQQAAQISDLERSLREQQGHLRQL 576
Cdd:TIGR00618  446 AITCTAQCEKLEKIHLQESAQSL---------KEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPA 516

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   577 EQELTRDEVLLCSQCGKEPSVAQDEKS--------------AILLREKEDCALQLLTAQNRFLEERKEIMEKFAKEQDAF 642
Cdd:TIGR00618  517 RQDIDNPGPLTRRMQRGEQTYAQLETSeedvyhqltserkqRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRL 596

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   643 LLDTQEKHSHELQLLQQGHQQQLlalrmELETKHHSELTEQLASLESKQQALLETHVAKMQV---KHDAEISALekrhLS 719
Cdd:TIGR00618  597 QDLTEKLSEAEDMLACEQHALLR-----KLQPEQDLQDVRLHLQQCSQELALKLTALHALQLtltQERVREHAL----SI 667

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   720 NLDELESCYVADIQTIRDEHKKALELLRAELeeqLQKKDSCHREILTQELEKLKlkHAEELQSVRNSLRVKMSAQHTESG 799
Cdd:TIGR00618  668 RVLPKELLASRQLALQKMQSEKEQLTYWKEM---LAQCQTLLRELETHIEEYDR--EFNEIENASSSLGSDLAAREDALN 742

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   800 KGPAADLQGAHQKAPAMALHNEGHQLEEDGDAALGgADTEDLQHHAEPREREGPH------TVEMQTSQTELAKPQELQA 873
Cdd:TIGR00618  743 QSLKELMHQARTVLKARTEAHFNNNEEVTAALQTG-AELSHLAAEIQFFNRLREEdthllkTLEAEIGQEIPSDEDILNL 821

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|...
gi 392355279   874 SQDQGAQVRDQVFLLSRE--------------LEECRGELEQLQQRRERENQE 912
Cdd:TIGR00618  822 QCETLVQEEEQFLSRLEEksatlgeithqllkYEECSKQLAQLTQEQAKIIQL 874
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 286-586 1.50e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 43.96  E-value: 1.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   286 QHQAAIRKLQEdlrSEHCQYLQDLELRFREKEKAKELELETLQASYEDLKAQSQEEIRHLWSQLESMKTNREEQNGSwep 365
Cdd:pfam17380  279 QHQKAVSERQQ---QEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELER--- 352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   366 lLAQASHLEELQHLRS-----DFAQQQQQERAQHESELEHLRVYFE----KKLNDAEKTYQEDLTVFQQRLQEAREESLE 436
Cdd:pfam17380  353 -IRQEERKRELERIRQeeiamEISRMRELERLQMERQQKNERVRQEleaaRKVKILEEERQRKIQQQKVEMEQIRAEQEE 431

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   437 SAEISSSCMFPEETSGRERkeppdpldLQLEQPKAQGSLIEDYQEKLSNAEEKIELMKQEFQKKEAEwELSREDLKRDAE 516
Cdd:pfam17380  432 ARQREVRRLEEERAREMER--------VRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAE-EQRRKILEKELE 502

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   517 EKLASMFLELREKAESEKLSIINRFELRESSMRHLQDQQAAQISDLERSLREQQgHLRQLEQELTRDEVL 586
Cdd:pfam17380  503 ERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQE-QMRKATEERSRLEAM 571
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1302-1422 1.60e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.60  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1302 AKLDEEVELLQEKLREKLDGFNELVIKKDLADQQLLIQEEEIKHLEETNENIQRQMAQ---------LQEELEKQRRSTE 1372
Cdd:COG1579    27 KELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNvrnnkeyeaLQKEIESLKRRIS 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 392355279 1373 ELE--------VVNSRNSEIEELKAIIEHLQENQEQLQKAKAEEIEQLHEVIEKLQSE 1422
Cdd:COG1579   107 DLEdeilelmeRIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAE 164
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 194-521 1.71e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 44.29  E-value: 1.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   194 LRNEQETAELKEKFRSEMEKTvQMMETLKQDWESERELclETLRKELSAKhqsemeglqnqfQKELSEQKAELEKIFQAK 273
Cdd:TIGR02169  203 LRREREKAERYQALLKEKREY-EGYELLKEKEALERQK--EAIERQLASL------------EEELEKLTEEISELEKRL 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   274 HEAEVSLKNLEAQHQA----AIRKLQEDLRSEHCQYLQdlelrFREKEKAKELELETLQASyedlKAQSQEEIRHLWSQL 349
Cdd:TIGR02169  268 EEIEQLLEELNKKIKDlgeeEQLRVKEKIGELEAEIAS-----LERSIAEKERELEDAEER----LAKLEAEIDKLLAEI 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   350 ESMKTNREEQNGSWEPLLAQASHL-EELQHLRSDFAQQQQQERAQHEsELEHLRVYFEkKLNDAEKTYQEDLTVFQQRLQ 428
Cdd:TIGR02169  339 EELEREIEEERKRRDKLTEEYAELkEELEDLRAELEEVDKEFAETRD-ELKDYREKLE-KLKREINELKRELDRLQEELQ 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   429 EAREEsLESAEISSSCMFPEETSGRERKEppdplDLQLEQPKAQGSLiEDYQEKLSNAEEKIELMKQEFQKKEAEwelsR 508
Cdd:TIGR02169  417 RLSEE-LADLNAAIAGIEAKINELEEEKE-----DKALEIKKQEWKL-EQLAADLSKYEQELYDLKEEYDRVEKE----L 485

                          330
                   ....*....|...
gi 392355279   509 EDLKRDAEEKLAS 521
Cdd:TIGR02169  486 SKLQRELAEAEAQ 498
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 1071-1422 1.92e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.06  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1071 EKEFRHRDEEMAQAVQKQQELLERLREEsaakdrlaleLHTAEGLLEGFKVEKADLQEALGKKEESEQQLIVELEDLRKQ 1150
Cdd:pfam12128  599 EEELRERLDKAEEALQSAREKQAAAEEQ----------LVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDK 668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1151 LQQASRELLTLKEEnsvlwnQKETFTNEAKEREAALQKEVESLTRDQWESRKQSEKDRatllsqmRVLESELEDQLvqhr 1230
Cdd:pfam12128  669 KNKALAERKDSANE------RLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYW-------QVVEGALDAQL---- 731

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1231 gcAQLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQATRPRPPGPR---------DSQC 1301
Cdd:pfam12128  732 --ALLKAAIAARRSGAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEVLRyfdwyqetwLQRR 809

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1302 AKLDEEVELLQEKLREkldgfnelvIKKDLADQQlliqeeeikhlEETNENIQRQMAQLQEELEKQRRSTEELEVVNSRN 1381
Cdd:pfam12128  810 PRLATQLSNIERAISE---------LQQQLARLI-----------ADTKLRRAKLEMERKASEKQQVRLSENLRGLRCEM 869

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 392355279  1382 SEIEELkaiieHLQENQEQLQKAKAEEIEQLHEVIEKLQSE 1422
Cdd:pfam12128  870 SKLATL-----KEDANSEQAQGSIGERLAQLEDLKLKRDYL 905
PTZ00121 PTZ00121
MAEBL; Provisional
 1026-1408 2.11e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 2.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1026 ENTQECEQPIRKVYQSLSTAVEglLDMALDSSKQLEDARQLHRCVEK--EFRHRDEEMAQAVQKQQELLERLREESAAKD 1103
Cdd:PTZ00121 1388 EEKKKADEAKKKAEEDKKKADE--LKKAAAAKKKADEAKKKAEEKKKadEAKKKAEEAKKADEAKKKAEEAKKAEEAKKK 1465

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1104 rlALELHTAEGLLEgfKVEKADLQEALGKKEESEQQLIVEL----------EDLRKQLQQASRELLTLKEENsvlwNQKE 1173
Cdd:PTZ00121 1466 --AEEAKKADEAKK--KAEEAKKADEAKKKAEEAKKKADEAkkaaeakkkaDEAKKAEEAKKADEAKKAEEA----KKAD 1537

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1174 TFTNEAKEREAALQKEVESLTRDQwESRKQSEKDRATLLSQMRVLESELEDQLVQHR--GCAQLAEEVTTLKQQLATLDK 1251
Cdd:PTZ00121 1538 EAKKAEEKKKADELKKAEELKKAE-EKKKAEEAKKAEEDKNMALRKAEEAKKAEEARieEVMKLYEEEKKMKAEEAKKAE 1616

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1252 HLRSQRQFM---DEQAAEREHEREEFQQEIKWLEgQLRQA-----TRPRPPGPRDSQCAKLDEEVELLQEKLREKLDGFN 1323
Cdd:PTZ00121 1617 EAKIKAEELkkaEEEKKKVEQLKKKEAEEKKKAE-ELKKAeeenkIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALK 1695

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1324 ELVIKKDLADQQLLIQEEEIKHLEE---TNENIQRQMAQLQEELEKQRRSTEELEVVNSRNSEIEELKAIIEHLQENQEQ 1400
Cdd:PTZ00121 1696 KEAEEAKKAEELKKKEAEEKKKAEElkkAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRK 1775


                  ....*...
gi 392355279 1401 LQKAKAEE 1408
Cdd:PTZ00121 1776 EKEAVIEE 1783
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1093-1290 2.14e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.21  E-value: 2.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1093 ERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEENSVLWNQK 1172
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1173 ETFTNEAKEREAALQK-----EVESLTRDqwESRKQSEKDRATLLSQMRVLESELEDQLVQHRGCAQLAEEVTTLKQQLA 1247
Cdd:COG4942   100 EAQKEELAELLRALYRlgrqpPLALLLSP--EDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 392355279 1248 TLDKHLRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQATR 1290
Cdd:COG4942   178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQ 220
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 1302-1422 2.15e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 43.08  E-value: 2.15e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279   1302 AKLDEEVELLQE---KLREKLDGFN-ELVIKKDLA------DQQLL-IQEEEIKHLEETNENIQRQMAQLQEELEkqrrs 1370
Cdd:smart00787  161 KLLMKELELLNSikpKLRDRKDALEeELRQLKQLEdeledcDPTELdRAKEKLKKLLQEIMIKVKKLEELEEELQ----- 235

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 392355279   1371 teELE-VVNSRNSEIEELKAIIEHLQENQEQLQKAKAEEIEQLHEVIEKLQSE 1422
Cdd:smart00787  236 --ELEsKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFKEIEKLKEQLKLLQSL 286
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 179-279 2.59e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 43.53  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  179 ELMREQHAREKEEMALRNEQETA--ELKEKFRSEMEKTVQMMETLKQDWESERELCLE--TLRKELSAKHqsemeGLQNQ 254
Cdd:COG0542   415 ELERRLEQLEIEKEALKKEQDEAsfERLAELRDELAELEEELEALKARWEAEKELIEEiqELKEELEQRY-----GKIPE 489

                          90       100
                  ....*....|....*....|....*
gi 392355279  255 FQKELSEQKAELEKIFQAKHEaEVS 279
Cdd:COG0542   490 LEKELAELEEELAELAPLLRE-EVT 513
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 198-345 2.70e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 42.56  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  198 QETAELKEKFRSEMEKTVQMMETLKQDWESeRELCLETLRKELSAKHQSEMEGLQNQFQKELSEQKAELEKifQAKHEAE 277
Cdd:cd16269   149 EDREKLVEKYRQVPRKGVKAEEVLQEFLQS-KEAEAEAILQADQALTEKEKEIEAERAKAEAAEQERKLLE--EQQRELE 225

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  278 VSLKNLEAQHQAAIRKLQEDLRSEHCQYLQDLE--LRFREKEKAKELELETLQASyedlkAQSQEEIRHL 345
Cdd:cd16269   226 QKLEDQERSYEEHLRQLKEKMEEERENLLKEQEraLESKLKEQEALLEEGFKEQA-----ELLQEEIRSL 290
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1058-1230 2.77e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.37  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1058 KQLEDARQLHRCVEkEFRHRDEEMAQAVQKQQEL---LERLREESAAKDRLALELHTAEGLLEGFKVEKADLQEALGKKE 1134
Cdd:COG4913   641 DALQERREALQRLA-EYSWDEIDVASAEREIAELeaeLERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLE 719

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1135 ESEQQLIVELEDLRKQLQQASRElltlkeensvlwNQKETFTNEAKEREAALQKEVESLTRDQWESRkqsekdRATLLSQ 1214
Cdd:COG4913   720 KELEQAEEELDELQDRLEAAEDL------------ARLELRALLEERFAAALGDAVERELRENLEER------IDALRAR 781

                         170
                  ....*....|....*.
gi 392355279 1215 MRVLESELEDQLVQHR 1230
Cdd:COG4913   782 LNRAEEELERAMRAFN 797
mukB PRK04863
chromosome partition protein MukB;
181-580 2.80e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 43.41  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  181 MR-EQHAREKEEMALRNEQETAELKEKFRSEMEKTVQMME----------TLKQDWESERE---LCLETLR-KELSAKHQ 245
Cdd:PRK04863  275 MRhANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMARelaelneaesDLEQDYQAASDhlnLVQTALRqQEKIERYQ 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  246 SEMEGL------QNQFQKELSEQKAELEKIFQAKHEAEVSLKNLEAQHQAAIrKLQEDLRSEHCQYLQDLElRFREKEKA 319
Cdd:PRK04863  355 ADLEELeerleeQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYQQAL-DVQQTRAIQYQQAVQALE-RAKQLCGL 432

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  320 KELELETLQASYEDLKAQSQE---EIRHLWSQLESMKTNREEQNGSWEPLLAQASHLEELQHLRSDFAQQQQQERAQHES 396
Cdd:PRK04863  433 PDLTADNAEDWLEEFQAKEQEateELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSEAWDVARELLRRLREQRHLA 512

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  397 E-LEHLRvyfeKKLNDAEKTYQEdltvfQQRLQEAREESlesaeissscmfpeetSGRERKEPPDPLDLQLEQpKAQGSL 475
Cdd:PRK04863  513 EqLQQLR----MRLSELEQRLRQ-----QQRAERLLAEF----------------CKRLGKNLDDEDELEQLQ-EELEAR 566

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  476 IEDYQEKLSNAEEKIELMKQEfqkkeaewelsREDLKRDAEE--KLASMFLELREKAEseklsiinrfELRESSMRHLQD 553
Cdd:PRK04863  567 LESLSESVSEARERRMALRQQ-----------LEQLQARIQRlaARAPAWLAAQDALA----------RLREQSGEEFED 625

                         410       420       430
                  ....*....|....*....|....*....|..
gi 392355279  554 QQA-----AQISDLERSLREQQGHLRQLEQEL 580
Cdd:PRK04863  626 SQDvteymQQLLERERELTVERDELAARKQAL 657
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1143-1367 2.96e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.37  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1143 ELEDLRKQ------LQQASRELLTLKEENSVLWNQKETFTNEAKEREAALQKEVESLTRDQWESRKQSEKDRATLLSQMR 1216
Cdd:COG4913   243 ALEDAREQiellepIRELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALR 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1217 VLESELEDQLVQHRGcaqlaEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQATRprppgp 1296
Cdd:COG4913   323 EELDELEAQIRGNGG-----DRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAA------ 391

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392355279 1297 rdsQCAKLDEEVELLQEKLREKLDGFNELviKKDLADQqlliqEEEIKHLEETNENIQRQMAQLQEELEKQ 1367
Cdd:COG4913   392 ---LLEALEEELEALEEALAEAEAALRDL--RRELREL-----EAEIASLERRKSNIPARLLALRDALAEA 452
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1327-1601 2.96e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.51  E-value: 2.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1327 IKKDLADQQLLIQ----EEEIKHLEETNENIQRQMAQLQEELEKQRRSTEELEVVNSRNSEIEELKAIIEHLQENQEQLQ 1402
Cdd:TIGR02168  218 LKAELRELELALLvlrlEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEI 297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1403 KAKAEEIEQLHEVIEKLQSELSlMGPTVHEMSDLPPGSLHTELSCLQAEGMGGQALHNELQAAQAAKGAFGQLLadhghS 1482
Cdd:TIGR02168  298 SRLEQQKQILRERLANLERQLE-ELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEEL-----E 371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1483 QALEALQERLQDAEAAAArhltELEHCVALRQAEVEAMASRIQEFEATLKAKEAIIVQRDLEIDAVNKWKVSHSVELEAL 1562
Cdd:TIGR02168  372 SRLEELEEQLETLRSKVA----QLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEE 447

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 392355279  1563 LLALAHFQHA-VEQQTSATPDEPPKLQQLLVQCARLSHQL 1601
Cdd:TIGR02168  448 ELEELQEELErLEEALEELREELEEAEQALDAAERELAQL 487
BspD6I-like cd22316
nicking endonuclease Nt.BspD6I and similar endonucleases; Heterodimeric type II restriction ...
 1302-1422 3.22e-03

nicking endonuclease Nt.BspD6I and similar endonucleases; Heterodimeric type II restriction endonuclease nicking endonuclease BspD6I recognizes a pseudosymmetric DNA sequence (5'-GAGTC) and cuts both strands outside the recognition motif 4 nucleotides downstream. It forms the large subunit in a heterodimeric arrangement. This catalytic domain/subunit belongs to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.


Pssm-ID: 411720  Cd Length: 345  Bit Score: 42.67  E-value: 3.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1302 AKLDEEVELLQEKLREKLDGFNELVIKKDLADqqlliqeeeIKHLEETNENIQRQMAQLQEELEKQRRSTEELEVVNS-- 1379
Cdd:cd22316    38 EKKVEVEEILSNVERKPIFFDSDDDYLEYLFN---------PALPPLDNDDKANLVLELLRIRLKERGILIKISSKPLlt 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 392355279 1380 ---RNSEIEELKAIIEHLQENQeqLQKAKAEEIEQLHEVIEKLQSE 1422
Cdd:cd22316   109 padLNIIRKELENKLKKLREKK--YAKRQAEDWEEILEYFDLIENR 152
PRK12704 PRK12704
phosphodiesterase; Provisional
 1305-1422 4.43e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 4.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1305 DEEVELLQEKLREKLDGFNELVIKKDLADQQLLIQEEEIKHLEetneniqRQMAQLQEELEKqrrsteELEVVNSRNSEI 1384
Cdd:PRK12704   46 EAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLE-------KRLLQKEENLDR------KLELLEKREEEL 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 392355279 1385 EELKAIIEHLQEN----QEQLQKAKAEEIEQLhEVIEKLQSE 1422
Cdd:PRK12704  113 EKKEKELEQKQQElekkEEELEELIEEQLQEL-ERISGLTAE 153
PTZ00121 PTZ00121
MAEBL; Provisional
 1053-1423 4.80e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 4.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1053 ALDSSKQLEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAK---DRLALELHTAEGLLEGFKVEKAdlqEA 1129
Cdd:PTZ00121 1492 AEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKaeeKKKADELKKAEELKKAEEKKKA---EE 1568

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1130 LGKKEESEQQLIVELEDLRKQLQQASRELLTLKEENSVLWNQKETFTNEAKEREAALQKEVESLTRDQWESRKQSEKDRa 1209
Cdd:PTZ00121 1569 AKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKK- 1647

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1210 tllsQMRVLESELEDQLVQHRGCAQLAEEVTTLKQQL--ATLDKHLRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQ 1287
Cdd:PTZ00121 1648 ----KAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAkkAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKK 1723

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1288 ATRPRPPgpRDSQCAKLDEEVELLQEKLREKLDGFNELvikkdladqQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQ 1367
Cdd:PTZ00121 1724 AEEENKI--KAEEAKKEAEEDKKKAEEAKKDEEEKKKI---------AHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKR 1792

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 392355279 1368 RRSTEELEVVNSRNSEIeelkaIIEHLQENQEQLQKAKAEEIEQLHEVIEKLQSEL 1423
Cdd:PTZ00121 1793 RMEVDKKIKDIFDNFAN-----IIEGGKEGNLVINDSKEMEDSAIKEVADSKNMQL 1843
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 1089-1412 4.90e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 42.52  E-value: 4.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1089 QELLERLRE---ESAAKDRLALE--LHTAEGLLEGFKVEKAdlqealgKKEESE-QQLIVELEDLRKQLQQASRELLTLK 1162
Cdd:PRK04778   63 EEKFEEWRQkwdEIVTNSLPDIEeqLFEAEELNDKFRFRKA-------KHEINEiESLLDLIEEDIEQILEELQELLESE 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1163 EENSvlwnqketftneakereaalqKEVESLTRDQWESRKQSEKDRATLLSQMRVLE---SELEDQLVQHrgcAQLAEE- 1238
Cdd:PRK04778  136 EKNR---------------------EEVEQLKDLYRELRKSLLANRFSFGPALDELEkqlENLEEEFSQF---VELTESg 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1239 -VTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEIKWLEGQLRQATRPRPPGPRDsqcaKLDEEVELLQEKLRE 1317
Cdd:PRK04778  192 dYVEAREILDQLEEELAALEQIMEEIPELLKELQTELPDQLQELKAGYRELVEEGYHLDHL----DIEKEIQDLKEQIDE 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1318 KLDgfnelvikkdladqqlLIQEEEIKHLEETNENIQRQMAQLQEELEKqrrsteELEVVNSRNSEIEELKAIIEHLQEN 1397
Cdd:PRK04778  268 NLA----------------LLEELDLDEAEEKNEEIQERIDQLYDILER------EVKARKYVEKNSDTLPDFLEHAKEQ 325

                         330
                  ....*....|....*
gi 392355279 1398 QEQLQkakaEEIEQL 1412
Cdd:PRK04778  326 NKELK----EEIDRV 336
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
 1072-1228 5.21e-03

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 41.67  E-value: 5.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1072 KEFRHRDEEMAQAVQKQQELLERLREESAAKDrlaLELHTAEGL-LEGFKVEKADLQEALGKKEESEQQLIVELEDLRKQ 1150
Cdd:pfam09787    7 QELADYKQKAARILQSKEKLIASLKEGSGVEG---LDSSTALTLeLEELRQERDLLREEIQKLRGQIQQLRTELQELEAQ 83

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392355279  1151 LQQasrELLTLKEENSVLwnqKETFTNEAKEREAAlQKEVESLTRDQWESRKQSEKDRATLLSQMRVLESELEDQLVQ 1228
Cdd:pfam09787   84 QQE---EAESSREQLQEL---EEQLATERSARREA-EAELERLQEELRYLEEELRRSKATLQSRIKDREAEIEKLRNQ 154
PLN02939 PLN02939
transferase, transferring glycosyl groups
 1056-1373 5.39e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 42.58  E-value: 5.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1056 SSKQLEDARQLHRCVEKEFRHRDEEMAQAVQKqqelLERLREEsaaKDRLALELHTAEgllegFKVEKADLQEALGKKEE 1135
Cdd:PLN02939  126 SDFQLEDLVGMIQNAEKNILLLNQARLQALED----LEKILTE---KEALQGKINILE-----MRLSETDARIKLAAQEK 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1136 SEQQLIVE-LEDLRKQLQQA-----------SRELLTLKEENSVLWNQKEtftneakereaALQKEVESLTRDQwESRKQ 1203
Cdd:PLN02939  194 IHVEILEEqLEKLRNELLIRgateglcvhslSKELDVLKEENMLLKDDIQ-----------FLKAELIEVAETE-ERVFK 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1204 SEKDRATLLSQMRVLESEL----EDQL-VQHRGCAQLAEEVTTLKQQLATLDKHLrsqrqfmdEQAAEREHEREEFQQEI 1278
Cdd:PLN02939  262 LEKERSLLDASLRELESKFivaqEDVSkLSPLQYDCWWEKVENLQDLLDRATNQV--------EKAALVLDQNQDLRDKV 333

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1279 KWLEGQLRQAtrprppgprdsQCAKLD-EEVELLQEKLREKLDGFnelvikkDLADQQLLIQeeeIKHLEETNENIQRQM 1357
Cdd:PLN02939  334 DKLEASLKEA-----------NVSKFSsYKVELLQQKLKLLEERL-------QASDHEIHSY---IQLYQESIKEFQDTL 392

                         330
                  ....*....|....*.
gi 392355279 1358 AQLQEELEKqrRSTEE 1373
Cdd:PLN02939  393 SKLKEESKK--RSLEH 406
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1346-1541 6.06e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.23  E-value: 6.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1346 LEETNENIQR----------QMAQLQEELEKQRRS---TEELEVV---------NSRNSEIEELKAIIEHLQENQEQLQK 1403
Cdd:COG1196   181 LEATEENLERledilgelerQLEPLERQAEKAERYrelKEELKELeaellllklRELEAELEELEAELEELEAELEELEA 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1404 AKAE---EIEQLHEVIEKLQSELSLMGPTVHEmsdlppgsLHTELSCLQAEGMGGQALHNELQAAQAAKGAFGQLLADH- 1479
Cdd:COG1196   261 ELAEleaELEELRLELEELELELEEAQAEEYE--------LLAELARLEQDIARLEERRRELEERLEELEEELAELEEEl 332

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392355279 1480 -GHSQALEALQERLQDAEAAAARHLTELEHCVALRQAEVEAMASRIQEFEATLKAKEAIIVQR 1541
Cdd:COG1196   333 eELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAA 395
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 232-499 6.33e-03

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 42.08  E-value: 6.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  232 CLETLRKELSA-KHQSEMEGLQNQFQKELSEQ---KAELEKIFQAKHEAEV-----SLKNLEAQHQAAIRKLQEDLRSEH 302
Cdd:PTZ00341  294 CRKIMNSDISSfKHINELKSLEHRAAKAAEAEmkkRAEKPKKKKSKRRGWLccgggDIETVEPQQEEPVQDVGEHQINEY 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  303 CQYLQDLELRFREK--------EKAKELELETLQASYED----LKAQSQEEIRHL-WSQLESMKTNREEQNG-SWEPLLA 368
Cdd:PTZ00341  374 GDILPSLKASINNSainyydavKDGKYLDDDSSDALYTDedllFDLEKQKYMDMLdGSEDESVEDNEEEHSGdANEEELS 453

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  369 QASHLEElQHLRSDFAQQQQQERAQHESELEhlrVYFEKKLNDaektYQEDLTVFQQRLQEAREESLESAEIssscmfpe 448
Cdd:PTZ00341  454 VDEHVEE-HNADDSGEQQSDDESGEHQSVNE---IVEEQSVNE----HVEEPTVADIVEQETVDEHVEEPAV-------- 517

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 392355279  449 etsgrERKEPPDPLDLQLEQPKAQGSLIedyQEKLSNAEEKIELMKQEFQK 499
Cdd:PTZ00341  518 -----DENEEQQTADEHVEEPTIAEEHV---EEEISTAEEHIEEPASDVQQ 560
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1060-1425 7.36e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 42.03  E-value: 7.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1060 LEDARQLHRCVEKEFRHRDEEMAQAVQKQQELLERLREESAAK-DRLALELHTAEGLLEGFKVEKADLQEALGKK-EESE 1137
Cdd:pfam15921  129 MADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLEDSNTQiEQLRKMMLSHEGVLQEIRSILVDFEEASGKKiYEHD 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1138 QQLIVELEDLRKQLQQASRELLT----LKEENSVLWNQKETFTNEAKER-EAALQK--------------EVESLTRDQW 1198
Cdd:pfam15921  209 SMSTMHFRSLGSAISKILRELDTeisyLKGRIFPVEDQLEALKSESQNKiELLLQQhqdrieqlisehevEITGLTEKAS 288

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1199 ESRKQSEkdraTLLSQMRVLESELEDQLVQH-RGCAQLAEEVTTLKQQLATLDK-------HLRSQRQFMDEQAAEREHE 1270
Cdd:pfam15921  289 SARSQAN----SIQSQLEIIQEQARNQNSMYmRQLSDLESTVSQLRSELREAKRmyedkieELEKQLVLANSELTEARTE 364

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1271 REEFQQEIKWLEGQLRQATrprppgprdSQCAKLDEEVELLQEKLRE--KLDGFNELVI---KKDLADQQLLIQEEE--I 1343
Cdd:pfam15921  365 RDQFSQESGNLDDQLQKLL---------ADLHKREKELSLEKEQNKRlwDRDTGNSITIdhlRRELDDRNMEVQRLEalL 435

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1344 KHLE-ETNENIQRQMAQLQ---EELEKQRRSTEELEvvnsrnSEIEELKAIIEHLQENQEQLQKA-------------KA 1406
Cdd:pfam15921  436 KAMKsECQGQMERQMAAIQgknESLEKVSSLTAQLE------STKEMLRKVVEELTAKKMTLESSertvsdltaslqeKE 509

                          410
                   ....*....|....*....
gi 392355279  1407 EEIEQLHEVIEKLQSELSL 1425
Cdd:pfam15921  510 RAIEATNAEITKLRSRVDL 528
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1102-1424 7.46e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.93  E-value: 7.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1102 KDRLALELHTAEGLLEGFKVEKADLQEALGKKEESEQQLIVELEDLRKQLQQASRELLTLKEENSvlwnQKETFTNEAKE 1181
Cdd:TIGR04523  119 KNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKL----NIQKNIDKIKN 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1182 REAALQKEVESLtrdqwesrKQSEKDRATLLSQMRVLE---SELEDQLVQ-HRGCAQLAEEVTTLKQQLATL-DKHLRSQ 1256
Cdd:TIGR04523  195 KLLKLELLLSNL--------KKKIQKNKSLESQISELKkqnNQLKDNIEKkQQEINEKTTEISNTQTQLNQLkDEQNKIK 266

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1257 RQFMDEQAAEREHERE---------EFQQEIKWLEGQLRQATRPRppgpRDSQCAKLDEEVELLQEKLREKLDGFNELvi 1327
Cdd:TIGR04523  267 KQLSEKQKELEQNNKKikelekqlnQLKSEISDLNNQKEQDWNKE----LKSELKNQEKKLEEIQNQISQNNKIISQL-- 340

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1328 kkdlaDQQLLIQEEEIKHLEETNENIQRQMAQLQEELEKQRRSTEE-LEVVNSRNSEIEELKAIIEHlQENQEQLQKAKA 1406
Cdd:TIGR04523  341 -----NEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSyKQEIKNLESQINDLESKIQN-QEKLNQQKDEQI 414

                          330
                   ....*....|....*...
gi 392355279  1407 EEIEQLHEVIEKLQSELS 1424
Cdd:TIGR04523  415 KKLQQEKELLEKEIERLK 432
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 1083-1423 7.89e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 41.86  E-value: 7.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1083 QAVQKQQELLERLREESAAkdrLALELHTAEGLLEGFKVEKADLQEALGKKEESEQQLIVELEDLRK----------QLQ 1152
Cdd:COG3096   340 QTALRQQEKIERYQEDLEE---LTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQaldvqqtraiQYQ 416

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1153 QASRELltlkEENSVLWNQKETFTNEAKEREAALQKEVESLTRDQWESRKQ--------SEKDRATLLSQMRVLESELED 1224
Cdd:COG3096   417 QAVQAL----EKARALCGLPDLTPENAEDYLAAFRAKEQQATEEVLELEQKlsvadaarRQFEKAYELVCKIAGEVERSQ 492

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1225 -------QLVQHRGCAQLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEIKwLEGQLRQAtrprppgpr 1297
Cdd:COG3096   493 awqtareLLRRYRSQQALAQRLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAAEE-LEELLAEL--------- 562

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 1298 DSQCAKLDEEVELLQEK---LREKLDGFNELVikKDLAD--------QQLLIQEEEikHLEETNENIQRQMAQLQEELEK 1366
Cdd:COG3096   563 EAQLEELEEQAAEAVEQrseLRQQLEQLRARI--KELAArapawlaaQDALERLRE--QSGEALADSQEVTAAMQQLLER 638

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 392355279 1367 QRRSTEElevvnsrNSEIEELKaiiEHLQENQEQLQKAKAEEIEQLHEVIEKLQSEL 1423
Cdd:COG3096   639 EREATVE-------RDELAARK---QALESQIERLSQPGGAEDPRLLALAERLGGVL 685
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2281-2456 8.01e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.82  E-value: 8.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2281 LEKQLAQNNQLCVALKHERAAKDNLQKELQIEASRCEALLAQEKGQLSElrkSLEAERsrslelsEALQHERLLTEQLSR 2360
Cdd:COG4913   293 LEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLE---QLEREI-------ERLERELEERERRRA 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2361 NAQEACAR---QDTQAQHALLRKLKAEKARALELEAMLEKVQKQAAhtqqqLEAQAQERCLELRREKERELELQRQR--- 2434
Cdd:COG4913   363 RLEALLAAlglPLPASAEEFAALRAEAAALLEALEEELEALEEALA-----EAEAALRDLRRELRELEAEIASLERRksn 437

                         170       180
                  ....*....|....*....|...
gi 392355279 2435 -DEHKIEQLQRLVRELRWKEEAP 2456
Cdd:COG4913   438 iPARLLALRDALAEALGLDEAEL 460
PTZ00121 PTZ00121
MAEBL; Provisional
 2266-2455 8.57e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 8.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2266 REGQSSRALEELKISLEKQLAQNNQLCVALKHERAAKDNLQKELQIEASRCEALLAQEKGQLSELRKSLEaERSRSLELS 2345
Cdd:PTZ00121 1243 KKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAE-EAKKADEAK 1321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2346 EALQHERLLTEQLSRNAQEACARQDTQAQHALLRKLKA----EKARALELEAMLEKVQKQAAHTQQQLEAQAQERCLELR 2421
Cdd:PTZ00121 1322 KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAeaaeEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAE 1401

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 392355279 2422 REKERELELQRQRDE-HKIEQLQRLVRELRWKEEA 2455
Cdd:PTZ00121 1402 EDKKKADELKKAAAAkKKADEAKKKAEEKKKADEA 1436
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 2176-2403 8.84e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 8.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2176 QEAASDVRKRLMVEQGAVQDLKSELHACKQENTNLLESLDKVQQEVLRLRAVLDGKENELKVVLEELECERGKGQVLQAQ 2255
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279 2256 QEEQQL------RHLQREGQSSRALEELKISLEKQLAQNNQLCVALKHERAAKDNLQKELQIEASRCEALLAQEKGQLSE 2329
Cdd:COG4942    99 LEAQKEelaellRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEA 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392355279 2330 LRKSLEAERsrslelsealqhERLLTEQLSRNAQEACARQDTQAQHALLRKLKAEKARaleLEAMLEKVQKQAA 2403
Cdd:COG4942   179 LLAELEEER------------AALEALKAERQKLLARLEKELAELAAELAELQQEAEE---LEALIARLEAEAA 237
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 1109-1421 9.70e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 41.38  E-value: 9.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1109 LHTAEGLLEGFKVEKA-------------------DLQEALGKKEESEQQLIVELEDLRKQLQQASRELLT--------- 1160
Cdd:pfam06160   69 LFEAEELNDKYRFKKAkkaldeieellddieedikQILEELDELLESEEKNREEVEELKDKYRELRKTLLAnrfsygpai 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1161 --LKEENSVLWNQKETFTN--------EAKEREAALQKEVESLtrdqwesrkqsEKDRATLLSQMRVLESELEDQLVQHR 1230
Cdd:pfam06160  149 deLEKQLAEIEEEFSQFEEltesgdylEAREVLEKLEEETDAL-----------EELMEDIPPLYEELKTELPDQLEELK 217

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1231 -GCAQLAEEvttlKQQLATLDkhlrsqrqfmdeqaaerehereeFQQEIKWLEGQLRQATrprppgprdSQCAKLD-EEV 1308
Cdd:pfam06160  218 eGYREMEEE----GYALEHLN-----------------------VDKEIQQLEEQLEENL---------ALLENLElDEA 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392355279  1309 ELLQEKLREKLDGFNEL----VIKKDLADQQLLIQEEEIKHLEETNENIQRQMAQLQ-------EELEKQRRSTEELEVV 1377
Cdd:pfam06160  262 EEALEEIEERIDQLYDLlekeVDAKKYVEKNLPEIEDYLEHAEEQNKELKEELERVQqsytlneNELERVRGLEKQLEEL 341

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 392355279  1378 NSRNSEIEELKA--------IIEHLQENQEQLQKAKAEEIeqlhEVIEKLQS 1421
Cdd:pfam06160  342 EKRYDEIVERLEekevayseLQEELEEILEQLEEIEEEQE----EFKESLQS 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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