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Conserved domains on  [gi|1785356505|ref|XP_002938553|]
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lysozyme C [Xenopus tropicalis]

Protein Classification

lysozyme C family protein( domain architecture ID 13014097)

lysozyme C family protein may catalyze the hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 20-147 9.67e-74

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


:

Pssm-ID: 340383  Cd Length: 126  Bit Score: 216.36  E-value: 9.67e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785356505  20 KLFERCELAGIMKKMGLDGYRGYSLPNWVCTAFFESSFYTDRTNFNrGDNSTDYGILQINSRWWCNDNKTPgSHNACNIN 99
Cdd:cd16897     1 KIFSRCELARILKRGGLDGYRGYSLANWVCLAYYESGFNTRATNEN-PDGSTDYGIFQINSRYWCNDGKTP-SKNLCHIS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1785356505 100 CRALLSDDITQSVICAKRVVRDPQGMEAWVGWRNHCKGRDLSQWIKDC 147
Cdd:cd16897    79 CSDLLNDDITDDIKCAKKIVKDPQGMGAWVAWRLHCEGRDLSRWLDGC 126
 
Name Accession Description Interval E-value
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 20-147 9.67e-74

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 216.36  E-value: 9.67e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785356505  20 KLFERCELAGIMKKMGLDGYRGYSLPNWVCTAFFESSFYTDRTNFNrGDNSTDYGILQINSRWWCNDNKTPgSHNACNIN 99
Cdd:cd16897     1 KIFSRCELARILKRGGLDGYRGYSLANWVCLAYYESGFNTRATNEN-PDGSTDYGIFQINSRYWCNDGKTP-SKNLCHIS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1785356505 100 CRALLSDDITQSVICAKRVVRDPQGMEAWVGWRNHCKGRDLSQWIKDC 147
Cdd:cd16897    79 CSDLLNDDITDDIKCAKKIVKDPQGMGAWVAWRLHCEGRDLSRWLDGC 126
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
20-148 6.63e-72

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 211.76  E-value: 6.63e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785356505   20 KLFERCELAGIMKKMGLDGYRGYSLPNWVCTAFFESSFYTDRTNFNRGdNSTDYGILQINSRWWCNDNKTPGSHNACNIN 99
Cdd:smart00263   1 KVFTRCELARELKRLGLDGYRGISLANWVCLAFHESGYNTQATNYNNG-GSTDYGIFQINSKYWCNDGKTPGSVNACGIS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1785356505  100 CRALLSDDITQSVICAKRVVRDpQGMEAWVGWRNHCKGRDLSQWIKDCK 148
Cdd:smart00263  80 CSKLLDDDITDDVKCAKKIVSD-QGIDAWVAWKNHCQGEDLSQWIRGCG 127
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 20-144 1.90e-58

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 177.61  E-value: 1.90e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785356505  20 KLFERCELAGIMKKMGLDGYRGYSLPNWVCTAFFESSFYTDRTNFNRGdnSTDYGILQINSRWWCNDNKTPGSHNACNIN 99
Cdd:pfam00062   1 KQFTRCELARELKKLGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNG--STDYGIFQINDKYWCKDGKTPQSVNICGIS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1785356505 100 CRALLSDDITQSVICAKRVVrDPQGMEAWVGWRNHCKGrDLSQWI 144
Cdd:pfam00062  79 CDKLLDDDITDDIMCAKKIL-DPQGIDAWLAWKPHCSE-DLEQWI 121
 
Name Accession Description Interval E-value
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 20-147 9.67e-74

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 216.36  E-value: 9.67e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785356505  20 KLFERCELAGIMKKMGLDGYRGYSLPNWVCTAFFESSFYTDRTNFNrGDNSTDYGILQINSRWWCNDNKTPgSHNACNIN 99
Cdd:cd16897     1 KIFSRCELARILKRGGLDGYRGYSLANWVCLAYYESGFNTRATNEN-PDGSTDYGIFQINSRYWCNDGKTP-SKNLCHIS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1785356505 100 CRALLSDDITQSVICAKRVVRDPQGMEAWVGWRNHCKGRDLSQWIKDC 147
Cdd:cd16897    79 CSDLLNDDITDDIKCAKKIVKDPQGMGAWVAWRLHCEGRDLSRWLDGC 126
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
20-148 6.63e-72

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 211.76  E-value: 6.63e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785356505   20 KLFERCELAGIMKKMGLDGYRGYSLPNWVCTAFFESSFYTDRTNFNRGdNSTDYGILQINSRWWCNDNKTPGSHNACNIN 99
Cdd:smart00263   1 KVFTRCELARELKRLGLDGYRGISLANWVCLAFHESGYNTQATNYNNG-GSTDYGIFQINSKYWCNDGKTPGSVNACGIS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1785356505  100 CRALLSDDITQSVICAKRVVRDpQGMEAWVGWRNHCKGRDLSQWIKDCK 148
Cdd:smart00263  80 CSKLLDDDITDDVKCAKKIVSD-QGIDAWVAWKNHCQGEDLSQWIRGCG 127
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 20-144 1.90e-58

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 177.61  E-value: 1.90e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785356505  20 KLFERCELAGIMKKMGLDGYRGYSLPNWVCTAFFESSFYTDRTNFNRGdnSTDYGILQINSRWWCNDNKTPGSHNACNIN 99
Cdd:pfam00062   1 KQFTRCELARELKKLGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNG--STDYGIFQINDKYWCKDGKTPQSVNICGIS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1785356505 100 CRALLSDDITQSVICAKRVVrDPQGMEAWVGWRNHCKGrDLSQWI 144
Cdd:pfam00062  79 CDKLLDDDITDDIMCAKKIL-DPQGIDAWLAWKPHCSE-DLEQWI 121
LYZ cd00119
C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1, ...
 20-144 1.56e-48

C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1,4-beta-N-acetylmuramidase) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have primarily bacteriolytic function; hydrolysis of peptidoglycans of prokaryotic cell walls and transglycosylation. LA is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose. Some lysozymes have evolved into digestive enzymes, both in mammals and invertebrates.


Pssm-ID: 340357  Cd Length: 122  Bit Score: 152.34  E-value: 1.56e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785356505  20 KLFERCELAGIMKKMGldGYRGYSLPNWVCTAFFESSFYTDRTNFNRgDNSTDYGILQINSRWWCNDNKTPGSHNACNIN 99
Cdd:cd00119     1 KVFTRCELARLLKDIG--GYGGISLPNWVCLMKHESGYDTQATNENN-NGSTDYGLFQINSRYWCKDGQTPGARNICDIS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1785356505 100 CRALLSDDITQSVICAKRVVRDpQGMEAWVGWRNHCKGRdLSQWI 144
Cdd:cd00119    78 CSKLLTDDITDAIMCAKKIVDD-KGIDAWVAWKNHCQNK-LRQYV 120
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 20-147 9.97e-44

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 140.05  E-value: 9.97e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785356505  20 KLFERCELAGIMKKMGLDgyRGYsLPNWVCTAFFESSFYTDRTNFNRGDNSTDYGILQINSRWWCNDNKtpGSHNACNIN 99
Cdd:cd16899     1 KIFTRCELARELRKLGVP--RSQ-LANWVCLAEHESSFNTTAVGGPNSDGSGDYGLFQINDKYWCSPGG--GSGNGCNVK 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1785356505 100 CRALLSDDITQSVICAKRVVRDpQGMEAWVGWRNHCKGRDLSQWIkDC 147
Cdd:cd16899    76 CEDLLDDDISDDVKCAKKIYKE-QGFNAWVGWKNKCKGKNLPSYS-DC 121
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 22-144 3.88e-43

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 138.72  E-value: 3.88e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785356505  22 FERCELAGIMKKMGLDGYRGYSLPNWVCTAFFESSFYTDRTNFNRGdnSTDYGILQINSRWWCNDNKTPGSHNACNINCR 101
Cdd:cd16898     3 FTKCELSQILKEHGLDGFNGISLPEWICVTFHTSGYDTQALVYNNG--STEYGLFQISNKGWCDDSQEPVSRNICGISCS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1785356505 102 ALLSDDITQSVICAKRVVRDPQGMEAWVGWRNHCKGrDLSQWI 144
Cdd:cd16898    81 KLLDDDITDDIACAKKILAIPKGIDYWKAHKPFCRE-DLDQWR 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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