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Conserved domains on  [gi|1698330710|ref|XP_003964864|]
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alpha-2,8-sialyltransferase 8F [Takifugu rubripes]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 76-349 1.40e-167

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467699  Cd Length: 271  Bit Score: 468.66  E-value: 1.40e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710  76 DKYKKFRSELSSKCQGFEKAIITQANTVVGSKIVYDGERKRSVKVSTEMFNTFPKEHPFPNKTWETCAVVGNGGILSDSG 155
Cdd:cd23971     1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 156 CGKMIDSAQFVIRCNLPPLNNGyqDHVGVKTDLVTANPSILFEKYGALMGRRRPFIESLRSYGNSLLLIPAFSYGHNTPV 235
Cdd:cd23971    81 CGREIDSADFVIRCNLPPLNDS--KDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 236 SLRAFYSIEDFGSPTRTIFFNPQYLQKLAVFWRSKGLRAVRLSSGLMVASLALELCSNVHLFGFWPFSNHPHGlRTLKNH 315
Cdd:cd23971   159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDG-NPISHH 237

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1698330710 316 YYDDIQTKKKFHAMPVEFELLLQLHTEGVLRLHL 349
Cdd:cd23971   238 YYDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
 
Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 76-349 1.40e-167

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 468.66  E-value: 1.40e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710  76 DKYKKFRSELSSKCQGFEKAIITQANTVVGSKIVYDGERKRSVKVSTEMFNTFPKEHPFPNKTWETCAVVGNGGILSDSG 155
Cdd:cd23971     1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 156 CGKMIDSAQFVIRCNLPPLNNGyqDHVGVKTDLVTANPSILFEKYGALMGRRRPFIESLRSYGNSLLLIPAFSYGHNTPV 235
Cdd:cd23971    81 CGREIDSADFVIRCNLPPLNDS--KDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 236 SLRAFYSIEDFGSPTRTIFFNPQYLQKLAVFWRSKGLRAVRLSSGLMVASLALELCSNVHLFGFWPFSNHPHGlRTLKNH 315
Cdd:cd23971   159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDG-NPISHH 237

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1698330710 316 YYDDIQTKKKFHAMPVEFELLLQLHTEGVLRLHL 349
Cdd:cd23971   238 YYDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 96-344 4.60e-101

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 299.14  E-value: 4.60e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710  96 IITQANTVVGSKIVYdGERKRSVKVSTEMFNTFPKEHPFPNKTWETCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLn 175
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 176 NGYQDHVGVKTDLVTANP-SILFEKYGALMGR--RRPFIESLRSY--GNSLLLIPAFSYGHNTPVSLRAFYSIEDFGS-- 248
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIpv 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 249 -PTRTIFFNPQYLQKLAVFW-RSKGLRAVRLSSGLMVASLALELCSNVHLFGFWPFSNHphglRTLKNHYYDDIQTKK-- 324
Cdd:pfam00777 159 dPDKVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDS----RGNSHHYYDNVLMKKgg 234

                         250       260
                  ....*....|....*....|..
gi 1698330710 325 --KFHAMPVEFELLLQLHTEGV 344
Cdd:pfam00777 235 fyGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 76-349 1.40e-167

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 468.66  E-value: 1.40e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710  76 DKYKKFRSELSSKCQGFEKAIITQANTVVGSKIVYDGERKRSVKVSTEMFNTFPKEHPFPNKTWETCAVVGNGGILSDSG 155
Cdd:cd23971     1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 156 CGKMIDSAQFVIRCNLPPLNNGyqDHVGVKTDLVTANPSILFEKYGALMGRRRPFIESLRSYGNSLLLIPAFSYGHNTPV 235
Cdd:cd23971    81 CGREIDSADFVIRCNLPPLNDS--KDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 236 SLRAFYSIEDFGSPTRTIFFNPQYLQKLAVFWRSKGLRAVRLSSGLMVASLALELCSNVHLFGFWPFSNHPHGlRTLKNH 315
Cdd:cd23971   159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDG-NPISHH 237

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1698330710 316 YYDDIQTKKKFHAMPVEFELLLQLHTEGVLRLHL 349
Cdd:cd23971   238 YYDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 78-349 2.00e-118

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 344.04  E-value: 2.00e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710  78 YKKFRSELSSKCQGFEKAIITQANTVVGSKIVYDGERKRSVKVSTEMFNTFPKEHPFPNKTWETCAVVGNGGILSDSGCG 157
Cdd:cd23991     3 HENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 158 KMIDSAQFVIRCNLPPLNNGYQDHVGVKTDLVTANPSILFEKYGALMGRRRPFIESLRSYGNSLLLIPAFSYGHNTPVSL 237
Cdd:cd23991    83 AEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALSF 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 238 RAFYSIEDFGSPTRTIFFNPQYLQKLAVFWRSKGLRAVRLSSGLMVASLALELCSNVHLFGFWPFSNHPHGlRTLKNHYY 317
Cdd:cd23991   163 KVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEG-KPISHHYY 241

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1698330710 318 DDIQTKKKFHAMPVEFELLLQLHTEGVLRLHL 349
Cdd:cd23991   242 DNQLPKPGFHSMPKEFYQLLQLHSKGILKLQF 273
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 79-349 3.67e-101

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 299.95  E-value: 3.67e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710  79 KKFRSELSSKCQGFEKaIITQANTVVGSKIVYDGERKRSVKVSTEMFNTFPKEHPFPNKTWETCAVVGNGGILSDSGCGK 158
Cdd:cd23963     4 DKFRKELERLLNTRKL-FLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 159 MIDSAQFVIRCNLPPLNNGYQDhVGVKTDLVTANPSILFEKYGALMGRRRP--FIESLRSYGNSLLLIPAFSYGHNTPVS 236
Cdd:cd23963    83 EIDSHDFVIRCNLPPIKGFEKD-VGRKTNLTTLNPSILKRRYNSLKKNRDRdkFLNRLKEYNGSILWYPKFSFKSSTNLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 237 LRAFYSIEDFGSPTRTIFFNPQYLQKLAVFWRSKGLRAvRLSSGLMVASLALELCSNVHLFGFWPFSNHPHGlRTLKNHY 316
Cdd:cd23963   162 LKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGLEK-RPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNG-RPVPYHY 239

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1698330710 317 YDDIQ--TKKKFHAMPVEFELLLQLHTEGVLRLHL 349
Cdd:cd23963   240 YDDLSpsTKNKVHNMPEEFKLLRELHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 96-344 4.60e-101

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 299.14  E-value: 4.60e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710  96 IITQANTVVGSKIVYdGERKRSVKVSTEMFNTFPKEHPFPNKTWETCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLn 175
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 176 NGYQDHVGVKTDLVTANP-SILFEKYGALMGR--RRPFIESLRSY--GNSLLLIPAFSYGHNTPVSLRAFYSIEDFGS-- 248
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIpv 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 249 -PTRTIFFNPQYLQKLAVFW-RSKGLRAVRLSSGLMVASLALELCSNVHLFGFWPFSNHphglRTLKNHYYDDIQTKK-- 324
Cdd:pfam00777 159 dPDKVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDS----RGNSHHYYDNVLMKKgg 234

                         250       260
                  ....*....|....*....|..
gi 1698330710 325 --KFHAMPVEFELLLQLHTEGV 344
Cdd:pfam00777 235 fyGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 81-349 2.96e-96

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 287.50  E-value: 2.96e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710  81 FRSELSSKCQGFEKAIITQANTVVGSKIVYDGERKRSVKVSTEMFNTFPKEHPFPnKTWETCAVVGNGGILSDSGCGKMI 160
Cdd:cd23989     6 FRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQ-LPLKKCSVVGNGGILKNSGCGQQI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 161 DSAQFVIRCNLPPLNNGYQDHVGVKTDLVTANPSILFEKYGALMGRRRPFIESLRSYGNSLLLIPAFSYGHNTPVSLRAF 240
Cdd:cd23989    85 DRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVY 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 241 YSIEDFGSPTRTIFFNPQYLQKLAVFWRSKGLRAVRLSSGLMVASLALELCSNVHLFGFWPFSNHPHGlRTLKNHYYDDI 320
Cdd:cd23989   165 YTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDE-RTISHHYYDNV 243

                         250       260
                  ....*....|....*....|....*....
gi 1698330710 321 QTKKKFHAMPVEFELLLQLHTEGVLRLHL 349
Cdd:cd23989   244 LPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 77-348 4.26e-96

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 287.12  E-value: 4.26e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710  77 KYKKFRSELSSKCQGFEKAIITQANTVVGSKIVYDGERKRSVKVSTEMFNTFPKEHPFPNKTWETCAVVGNGGILSDSGC 156
Cdd:cd23990     2 EANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 157 GKMIDSAQFVIRCNLPPLNNGYQDHVGVKTDLVTANPSILFEKYGALMGRRRPFIESLRSYGNSLLLIPAFSYGHNTPVS 236
Cdd:cd23990    82 GREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 237 LRAFYSIEDFGSPTRTIFFNPQYLQKLAVFWRSKGLRAVRLSSGLMVASLALELCSNVHLFGFWPFSNHPHGLRtLKNHY 316
Cdd:cd23990   162 IRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIF-ITHHY 240

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1698330710 317 YDDIQTKKKFHAMPVEFELLLQLHTEGVLRLH 348
Cdd:cd23990   241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRVH 272
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 97-349 2.25e-71

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 224.58  E-value: 2.25e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710  97 ITQANTVVGSKIVYDGERKRSV-KVSTEMFNTFPKEHPFPNKTWETCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLn 175
Cdd:cd23970    25 LTKKDVRIGQLMHFDYSSHKYVfSISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPT- 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 176 NGYQDHVGVKTDLVTANPSILFEKYGALMGR--RRPFIESLRSYGNSLLLIPAFSYGHNTPVslraFYSIEDF-----GS 248
Cdd:cd23970   104 EGFEKDVGRKTNLTTFNPSILEKYYNNLLTIqdRNNFFLSLKKLDGAILWIPAFFFHTSATV----TRTLVDFfvehrGQ 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 249 PTRTIFFNPQYLQKLAVFWRSKGLRAVRLSSGLMVASLALELCSNVHLFGFWPFSNHPHGlRTLKNHYYDDIQTK----- 323
Cdd:cd23970   180 LKVQLAWPGNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTG-TPLPYHYYDKKGTKfttkw 258

                         250       260
                  ....*....|....*....|....*.
gi 1698330710 324 KKFHAMPVEFELLLQLHTEGVLRLHL 349
Cdd:cd23970   259 QESHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 97-348 4.65e-69

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 218.05  E-value: 4.65e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710  97 ITQANTVVGSKIVYDGERKRSVKVSTEMFNTFPKEHPFPNKTWETCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLnN 176
Cdd:cd23969    22 VLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPV-E 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 177 GYQDHVGVKTDLVTANPSILFEKYGALMGR--RRPFIESLRSYGNSLLLIPAFSyghNTPVSLRAFYS---IEDFGSPTR 251
Cdd:cd23969   101 GYEKDVGTKSNLTTMNPSVIPHAYGDLVNAtdKEKFVERLRQLGDSILWIPAFV---SKGGEEHVQWTneiILKHKLNVK 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 252 TIFFNPQYLQKLAVFWRSKGLRAVRLSSGLMVASLALELCSNVHLFGFWPFSNHPHGlRTLKNHYYDDIQ--TKKKFHAM 329
Cdd:cd23969   178 TAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNG-RAVKYHYYDNRKylTTARPHKM 256

                         250
                  ....*....|....*....
gi 1698330710 330 PVEFELLLQLHTEGVLRLH 348
Cdd:cd23969   257 PEEFRALRSLHQRGALRLH 275
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 105-347 4.10e-54

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 179.77  E-value: 4.10e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 105 GSKIVYDGERKRSVKVSTEMFNTFPKEHPFPNKTWETCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLnNGYQDHVGV 184
Cdd:cd23988    30 GDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPV-VEFAADVGT 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 185 KTDLVTANPSILFEKYGALMGR--RRPFIESLRSYGNSLLLIPAFSY--GHNTPVSLRAFysIEDFGSPTRTIFFNPQYL 260
Cdd:cd23988   109 KSDFITMNPSVVQRAFGGFRNEsdREKFVHRLSMLNDSVLWIPAFMVkgGEKHVEWVNAL--ILKNKLKVRTAYPSLRLI 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 261 QKLAVFWRSKGLRAVRLSSGLMVASLALELCSNVHLFGFWPFSNHPHGlRTLKNHYYDDIQTK----KKFHAMPVEFELL 336
Cdd:cd23988   187 HAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANG-NPVKYHYYDDLKYRyfsnAGPHRMPLEFKTL 265

                         250
                  ....*....|.
gi 1698330710 337 LQLHTEGVLRL 347
Cdd:cd23988   266 NVLHNRGALKL 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 105-349 7.57e-53

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 176.28  E-value: 7.57e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 105 GSKIVYDGERKRSVKVSTEMFNTFPKEHPFPNKTWETCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLNNgYQDHVGV 184
Cdd:cd23987    30 GDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEE-YAKDVGT 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 185 KTDLVTANPSILFEKYGALMGR--RRPFIESLRSYGNSLLLIPAF-SYGHNTPVSLrAFYSIEDFGSPTRTIFFNPQYLQ 261
Cdd:cd23987   109 KTDLVTMNPSVVQRAFEDLVNEtwKEKFLQRLQSLNGSILWIPAFmAKGGEERVEW-VNDLILKHHINVRTAYPSLRLLH 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 262 KLAVFWRSKGLRAVRLSSGLMVASLALELCSNVHLFGFWPFSNHPHGlRTLKNHYYDDIQ----TKKKFHAMPVEFELLL 337
Cdd:cd23987   188 AVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQ-NPVKYHYYDSLKygytSQASPHTMPLEFKALK 266

                         250
                  ....*....|..
gi 1698330710 338 QLHTEGVLRLHL 349
Cdd:cd23987   267 NLHQQGALKLTV 278
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 142-339 7.02e-29

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 110.92  E-value: 7.02e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 142 CAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPlNNGYQDHVGVKTDLVTANPSILfekyGALMGRRRPFIESLRSYGNSL 221
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAP-TKGFEKDVGSKTTFRVLNSKWA----GFYLRGPRCGCHPLPLEEEVV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 222 LLIPAFSYGHNTPVSLRAFYSiedFGSPTRTIFFNPQYLQKLAVFWRSKGLRAV----RLSSGLMVASLALELCSNVHLF 297
Cdd:cd19952    76 LILSRAAAADFKRLKRRKKRH---DNAVLLLTDPAPDLLSYVRKRLEKLGLKSFfggnAPSSGLLAVLLALQLCDSVDLY 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1698330710 298 GFWPFSNHPHGlrtLKNHYYDDIQTKK--KFHAMPVEFELLLQL 339
Cdd:cd19952   153 GFGVDSGHAPK---VPYHYYDLVEAEEgtAVHSFDLEAELLRAL 193
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 141-349 3.10e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 87.11  E-value: 3.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 141 TCAVVGNGGILSDSGCGKMIDSAQFVIRCNlPPLNNGYQDHVGVKTDLV--TANpSIL-----FEKYG---ALMGRRRPF 210
Cdd:cd23973    85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVN-GAVIKGYEEDVGTRTSFYvhTAH-SITsslmiLQKRGfknIPQDKDIKY 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 211 I---ESLRSYG--NSLLL---IPAFSYGHNTPvslRAFYSiEDFgSPTRTIFFNPQYLQKLA-VFWRSKGL-----RAVR 276
Cdd:cd23973   163 IlfpEGPRDYQwlEALLKnktIPSGAYYGRRP---RSYFS-GDF-TEDKYLVLHPDFLRYVKnRFLRSKTLkgkywAIYR 237

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1698330710 277 LSSGLMVASLALELCSNVHLFGFWpfsnhPHGLRTLKNHYYDDIQTKKKF---HAMPVEFELLLQLHTEGVLRLHL 349
Cdd:cd23973   238 PTTGAFLLLTALHLCDTVSAYGFI-----TEDYRKYPDHYYDKKKTKLVFyinHDFRLEKKLWKRLHDEKIIKLYQ 308
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 119-348 2.19e-16

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 78.48  E-value: 2.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 119 KVSTEMFNTFPKEHPF----PNKTwETCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLnNGYQDHVGVKTDLVTANPs 194
Cdd:cd23966    54 EVLEKLFQVVPGENPYrtrdPNRC-RRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPT-KGFEKDVGSKTTHHFMYP- 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 195 ilfekygalmgrrrpfiESLRSY--GNSLLLIP-----------AFSYGH--NTPVSLRAFYSIedfgSPTRTIFFNPQY 259
Cdd:cd23966   131 -----------------ESAVDLdpGVHLVLVPfkvldlqwlisALTTGEitRTYTPVKRFIKA----DKDKVLVINPAF 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 260 LQKLAVFWRSKGLRAVrlSSGLMVASLALELCSNVHLFGFwpfsnhphGLRTLKN--HYYDDIQTKKKF-----HAMPVE 332
Cdd:cd23966   190 IKYVHDNWTEHHGRYP--STGFLALIFALHICDEVSVFGF--------GADSKGNwhHYWEKNRSAGAFrktgvHDADFE 259

                         250
                  ....*....|....*.
gi 1698330710 333 FELLLQLHTEGVLRLH 348
Cdd:cd23966   260 SDIIKKLAKEGKIRVY 275
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 142-324 7.69e-16

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 75.41  E-value: 7.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 142 CAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLnNGYQDHVGVKTDLVTANPSilfekyGAlmgrrrpFIESLRSYGNSL 221
Cdd:cd23967     5 CVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPV-KGYEKDVGSKTTFRMFYPE------SA-------FRDPEEYDSDWL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 222 LLIPAFS-----------YGHNTPVSLRAFYSIEDF--GSPTRTIFFNPQYLQKLAV----FWRSKGLRAVRLSSGLMVA 284
Cdd:cd23967    71 LVLVPFKsmdllwlqaviKGKKPNGKGGFWKKIATSvpKPPKKIRILNPYILQEAAFdligLPMNGKQGKNVPTTGIIAI 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1698330710 285 SLALELCSNVHLFGFwpfsNHPHGLRTLKNHYYDDIQTKK 324
Cdd:cd23967   151 VMALHYCDEVDIAGF----GYDPSDPNAPLHYYDSLTMKA 186
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 114-340 1.57e-15

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 75.77  E-value: 1.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 114 RKRSVKVSTEMFNTF-PKEHPFPN------KTWETCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLnNGYQDHVGVKT 186
Cdd:cd23968    13 PFSTLRKTTSPFKDLlSLRYPFPEsslentKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPT-KGFEKDVGSKT 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 187 DLVTANPSILFekygalmgRRRPFIESLRSYGNSLLLI--PAfSYGhntpVSLRAFYSIEDFGS-----------PTRTI 253
Cdd:cd23968    92 TLRLINSQILS--------KPEFNFLTDPLYRNVTLLVwdPS-SYN----VNLEKWYKKPDFDFfpnyikyrrrhPEEPF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 254 FF-NPQYLQKLavfW----RSKGLRAVRL--SSGLMVASLALELCSNVHLFGFWPfSNHphglRTLKNHYYDDI----QT 322
Cdd:cd23968   159 YLiDPRFLWRL---WdilqEYTPEKIKPNppSSGFIGIVLMLHLCDWVDVYEYVP-SVR----QTDRCHYYDVEkdlaCT 230

                         250
                  ....*....|....*...
gi 1698330710 323 KKKFHamPVEFELLLQLH 340
Cdd:cd23968   231 LGAWH--PLAAEKLLVRH 246
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 112-348 1.65e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 76.14  E-value: 1.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 112 GERKRSVKVSTEMFNTFPK-EHPFPNKTWE------TCAVVGNGGILSDSGCGKMIDSAQFVIRCNLpPLNNGYQDHVGV 184
Cdd:cd23964    48 GWGGLNREVVERLLRNLNLtSSRYMFVLRGgrprciRCAVVGNGGILNGSGKGKEIDAHDYVFRVNH-ALTKGFEKDVGT 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 185 KT-----------------DLVTANPSILFEkygalmgrrrPFIESLRSYGNSLLL---IPAFSYGHNTPVSLRAFysie 244
Cdd:cd23964   127 KTsfytffpeslhnsllkhVPQDKDTKYLFI----------PFKIRDYDYLDAVLSgkpVPDGCDKGKRPPPLFGP---- 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 245 dFGSPTRTIFFNPQYLQKLAVFW-RSKglRAVRLSSGLMVASLALELCSNVHLFGF---WPFSnhphglrtlkNHYYDdi 320
Cdd:cd23964   193 -KLNATNVRLLHPDFIRYLFNRWlNSS--TSYRPTTGALMLLTALHTCDQVSVYGFgydPRFS----------LHYYD-- 257

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1698330710 321 QTKKKF------HAMPVEFELLLQLHTEGVLRLH 348
Cdd:cd23964   258 KTFVKFtvfyanHDFTNERKLWRKLHEEGIINLY 291
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 141-339 5.33e-14

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 70.16  E-value: 5.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 141 TCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLnNGYQDHVGVKTDLVTANP-SIlfekygalmgrrrpFIESLRSYGN 219
Cdd:cd23984     4 KCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPV-IGYENDVGKRTTFRLCYPeSI--------------FSDPSHYDPN 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 220 SLLLIPAFS----------YGHNtPVSLRAFYSIedfgsPTRTIFF--------NPQYLQKLAVFWRS------KGLRAV 275
Cdd:cd23984    69 TTVVLIPFKphdlrwlldlLMGK-KVSAKGFWKK-----PALNLIYkpnqirilNPFILRIAAYELLHfpkrfpKEKKPK 142

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1698330710 276 RLSSGLMVASLALELCSNVHLFGF-WPFSNHPHGLrtlknHYYDD----IQTKKKFHAMPVEFELLLQL 339
Cdd:cd23984   143 HPTTGIIAITLALHICNEVHIAGFkYDFSNLNSTL-----HYYGNetmsVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 131-348 8.62e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 62.15  E-value: 8.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 131 EHPFPNKTWEtCAVVGNGGILSDSGCGKMIDSAQFVIRCNlPPLNNGYQDHVGVKTDL------VTANPSILFEKYGAL- 203
Cdd:cd23972    75 PRDTPGKCIR-CAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFygftvnTMKNSLISYWNLGFTr 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 204 ----MGRRRPFIES-LRSY---GNSLLLIPAFSyGHNTPVSLRAFYSIEdfGSPTRTIFFNPQYLQKLAV-FWRSKGLRA 274
Cdd:cd23972   153 tpqgQDLQYIFIPSdIRDYvmlRSAILGVPVPE-GLDKGDRPHKYFGPE--ASAKKFKLLHPDFISYLTDrFLKSKLLNT 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 275 -----VRLSSGLMVASLALELCSNVHLFGF-----WPFSnhphglrtlkNHYYDDIQTKKKF---HAMPVEFELLLQLHT 341
Cdd:cd23972   230 hyghlYMPSTGALMLLTALHTCDQVSAYGFitsnyWKFS----------DHYYERKKKPLVFyanHDMLLEAALWRRLHK 299


                  ....*..
gi 1698330710 342 EGVLRLH 348
Cdd:cd23972   300 AGILQLY 306
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 141-319 4.01e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 59.18  E-value: 4.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 141 TCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLnNGYQDHVGVKTDL-VTAN---PSILFEKYGALMGRRRPFIesLRS 216
Cdd:cd23965     3 TCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPT-RGYEKDVGRRTTIrVVSHsslPRLLRNAILLLAGTRAPTV--VVF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 217 YGNSLLLIPAFSYGHNTPVSLRAFYSIEDFGSPTRTiffnpQYLQKLAVFWRSKGL--RAVR--LSSGLMVASLALELCS 292
Cdd:cd23965    80 WGPETKMNKDGAGKYNLLRSLSKKYPDVEFYSLTPE-----KMDYADELFEKETGKsrIKSGtwLSTGWFTMLLALDVCD 154

                         170       180       190
                  ....*....|....*....|....*....|
gi 1698330710 293 NVHLFGFWP---FSNHPHglRTLKNHYYDD 319
Cdd:cd23965   155 EIKVYGMVPenyCREHPN--SKVPYHYYEP 182
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 142-349 4.10e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 60.15  E-value: 4.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 142 CAVVGNGGILSDSGCGKMIDSAQFVIRCNlPPLNNGYQDHVGVKTDLVTANPSILFEK---YGALMGRRRPFIESLR--- 215
Cdd:cd23974    87 CAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTLMNSlraYAGVGFNGPPQSKETRyif 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 216 --SYGNSLLLIPAFSYghNTPVSL---RAFYSIEDFGSPTRT---IFFNPQYLQKLA-VFWRSKGL-----RAVRLSSGL 281
Cdd:cd23974   166 lpDHDRDYLLVKAALT--HTPIDRgrdKSKRPSKYFGKDVTAekfKIYHPDFIRYLRnRFLWSPILntkqrDIYRPSTGA 243

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1698330710 282 MVASLALELCSNVHLFGFWP-----FSnhphglrtlkNHYYDDIQTKKKF---HAMPVEFELLLQLHTEGVLRLHL 349
Cdd:cd23974   244 VMLLAALHTCDQVSAYGFMTpdygkYS----------DHYYDKTYHKVVFyanHDLRLEMQLWQKLHKAGLIKLYM 309
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 141-339 1.23e-09

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 57.37  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 141 TCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLnNGYQDHVGVKTDLVTANP-SILFEkygalmgrrrPFIESLRsygN 219
Cdd:cd23982     4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPV-RGFEKDVGSKTTIRLFYPeSAQFD----------PGIENDP---D 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 220 SLLLIPAFSyghntPVSLRAFYSIEDFGSPTRTIFF-----------------NPQYLQKLAV-FWRSKGLR--AVRLSS 279
Cdd:cd23982    70 TLLVLVPFK-----PLDFYWLYEILSNEKRVRKGFWkqppriwdanpkqirilNPYYTYVAATkLLQVPGQRkkKQKPTT 144

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1698330710 280 GLMVASLALELCSNVHLFGF-WPFSNHPhglrTLKNHYYDDIQTKK---KFHAMPVEFELLLQL 339
Cdd:cd23982   145 GLLAITLALHLCDEVHIAGFgYPDNGNS----NQPIHYYNQITLKSmanSGHNLNAEAQAIQRL 204
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 113-186 3.32e-08

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 53.94  E-value: 3.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 113 ERKRSVKVST-----EMFNTFPKEHPFPNKT-------WETCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPlNNGYQD 180
Cdd:cd23985     7 ELKDKVNVSMlegtdFPFNTSEWEGYLPKKSlreevgpLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAP-TAGFQQ 85


                  ....*.
gi 1698330710 181 HVGVKT 186
Cdd:cd23985    86 DVGTKT 91
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 142-326 5.06e-08

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 52.82  E-value: 5.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 142 CAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLnNGYQDHVGVKTDLVTANPSilfekyGAlmgrrrPfiESLRSYGNSL 221
Cdd:cd23983     5 CVVVGSGGILHGLELGHLLDQFDIVIRLNNAPV-QGYSQDVGNKTTIRMTYPE------GA------P--KSEQEYDPTS 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 222 LLIpAFSYGH-----------NTPVSL--RAFYSIEDFGS----PTRTIFFNPQYLQKLAV------------FWRSKGL 272
Cdd:cd23983    70 LFV-AVLFKSvdfawlkamvkKEPLSFwsRLFFWKEVADSiplkPSQFRILNPLIIKETALdilqypepqsrlWGWDKNV 148

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1698330710 273 RAVrlssGLMVASLALELCSNVHLFGFWPFSNHPHglrtLKNHYYD-------------DIQTKKKF 326
Cdd:cd23983   149 PTL----GVTAVVLATHLCDEVSLAGFGYDLSQPH----APLHYYDsvcmaamntqtmhNVTKETKF 207
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 119-299 8.17e-08

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 52.95  E-value: 8.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 119 KVSTEMFNTFPKEHPFpnKTWET-----CAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPlNNGYQDHVGVKTDL----- 188
Cdd:cd23979    57 EVLSKLFQIIPGENPY--RSWDPsrcrrCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVGSRTTHhfmyp 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 189 -----VTANPSILFEKYGALmgrRRPFIESLRSYGNSlllipAFSYGhntPVslRAFYSIEDfgspTRTIFFNPQYLQKL 263
Cdd:cd23979   134 esaknLPANVSFVLVPFKTL---DLLWITSALSTGQI-----RFTYA---PV--KQFLRVDK----DKVQIYNPAFFKYI 196

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1698330710 264 AVFWRSKGLRAVrlSSGLMVASLALELCSNVHLFGF 299
Cdd:cd23979   197 HDRWTEHHGRYP--STGMLVLFFALHVCDEVNVYGF 230
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 130-337 1.10e-06

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 49.45  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 130 KEHPFPNKTWE-----------------TCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPlNNGYQDHVGVKTDLVTAN 192
Cdd:cd23986    23 KEAPFSALGWEkyvpkiplsklhlrgfrSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIIN 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 193 PSIlfekygaLMGRRRPFIESlRSYGNSLLLI--PAFSYghntpVSLRAFYSIEDFG-----------SPTRTIF-FNPQ 258
Cdd:cd23986   102 SQI-------LTNPNHHFIDS-SLYKDVILVAwdPAPYS-----ANLHKWYKKPDYNlftpyvqyrkrNPNQPFYiLHPK 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 259 YLQKLAVFWRSKGLRAVR---LSSGLMVASLALELCSNVHLFGFWPfSNHPHGLRTLKNHYYDDIQTKKKFHamPVEFEL 335
Cdd:cd23986   169 FIWQLWDIIQENTQEKIQpnpPSSGFIGILIMMSMCREVHVYEYIP-SVRQTDLCHYHERYYDAACTLGAYH--PLLYEK 245


                  ..
gi 1698330710 336 LL 337
Cdd:cd23986   246 LL 247
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 142-339 3.32e-06

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 47.22  E-value: 3.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 142 CAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLnNGYQDHVGVKTDLVTANPSilfekyGAlmgrrrpfIESLRSY-GNS 220
Cdd:cd23981     5 CIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPV-KGFEKDVGSKTTLRITYPE------GA--------IQKPEQYeKDS 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 221 LLLIPAFS-----------YGHNTPVSLRAFYSIEDF--GSPTRTIFFNPQYLQKLAVfwrskGLRAVRLSSGLM----- 282
Cdd:cd23981    70 LFVLAGFKwqdfkwlkyivYKEKVSASDGFWKSVATRvpREPHEIRILNPYFIQEAAF-----SFIGLPFNNGLMgrgni 144

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1698330710 283 -----VA-SLALELCSNVHLFGFWPFSNHPHGlrtlKNHYYDDIQT---KKKF-HAMPVEFELLLQL 339
Cdd:cd23981   145 ptlgsVAiTMALHNCDEVAVAGFGYDMNTPNA----PLHYYETIKMsaiKESWtHNIQREKEFLRKL 207
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 142-318 3.76e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 47.54  E-value: 3.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 142 CAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPLNnGYQDHVGVKTDL-VTANPSIlfekYGALmgrRRPfiESLRSYGNS 220
Cdd:cd23978     4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTT-GYEKDVGNKTTLrVVAHSSV----YRVL---RRP--QEFLNRTPE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 221 LLLI---PAFSYGHNTPVSLRAFYSIEDFGSPTRTIF-FNPQYLQKLAVFWRSKGLRAVR-----LSSGLMVASLALELC 291
Cdd:cd23978    74 TTLIfwgPPNKMQKDGKSNLFRIIQRASMTFPNMSAFvVSPRRMRQFDDLFRGETGRDRKkshswLSTGWFTMVIAVELC 153

                         170       180
                  ....*....|....*....|....*....
gi 1698330710 292 SNVHLFGFWP--FSNHPHGLRTLKNHYYD 318
Cdd:cd23978   154 DNVHVYGMVPpnYCSKRPTPKKMPYHYYE 182
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 140-318 1.65e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 45.63  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 140 ETCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPlNNGYQDHVGVKTDL-VTANPS---ILFEKYGALMGRRRPFI---- 211
Cdd:cd23976    16 KSCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLrVIAHSSiqrILRNRNELLNVSQGTVFifwg 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 212 --ESLRSYGNSLLlipafsYGHntpvsLRAFYSIedfgSPTRTIFF--NPQYLQKLAVFWRSKG----LRAVRLSSGLMV 283
Cdd:cd23976    95 psNYMRRDGKGLV------YNN-----LQLMNQI----LPKLKVYTitRHKMLQFDELFKRETGkdrkISNTWLSTGWFT 159

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1698330710 284 ASLALELCSNVHLFGFWP--FSNHPHGlRTLKNHYYD 318
Cdd:cd23976   160 MIIALELCDRINVYGMVPpdFCRDPNH-PSVPYHYYE 195
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 141-299 3.87e-05

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 44.87  E-value: 3.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 141 TCAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPlNNGYQDHVGVKTDLVTANPsilfekygalmgrrrpfiESLRSYGN- 219
Cdd:cd23980    83 RCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADVGSKTTHHFVYP------------------ESFRELAQn 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 220 -SLLLIPAFSyghntpVSLRAFYSIEDFGSPTRT---------------IFFNPQYLQKLAVFWRSKGLRAVrlSSGLMV 283
Cdd:cd23980   144 vSMILVPFKT------LDLEWVISATTTGTISHTyvpvprkikvkkekiLIYHPAFIKYVFDRWLQGHGRYP--STGILS 215

                         170
                  ....*....|....*.
gi 1698330710 284 ASLALELCSNVHLFGF 299
Cdd:cd23980   216 VIFSLHVCDEVDLYGF 231
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 142-318 3.50e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 41.39  E-value: 3.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 142 CAVVGNGGILSDSGCGKMIDSAQFVIRCNLPPlNNGYQDHVGVKTDL-VTANPSI--LFEKYGALMGRRRPFIESLRSYG 218
Cdd:cd23977     4 CAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLrVVSHTSVplLLRNQGYFFQQSRDTKYVIWGPE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698330710 219 NSLLLIPAfSYGHNTPVSLRAFYSIEDFGSPTRTIFfnpQYLQKlaVFWRSKGLRAVR----LSSGLMVASLALELCSNV 294
Cdd:cd23977    83 RNMDRDGG-GKTYRALLTLAKMYPHLQVYTLTEEKM---AYCDG--VFQNETGKNRMKsgsfLSTGWFTMILALELCEEI 156

                         170       180
                  ....*....|....*....|....*....
gi 1698330710 295 HLFGFWPFS-----NHPhglrTLKNHYYD 318
Cdd:cd23977   157 LVYGMVSDSycrnkNHS----SVPYHYYE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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