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Conserved domains on  [gi|513211346|ref|XP_004934547|]
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two pore channel protein 1 isoform X1 [Gallus gallus]

Protein Classification

ion transporter( domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium, across cell membranes

Gene Ontology:  GO:0034220|GO:0005216
PubMed:  15816170
TCDB:  1.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
440-691 2.93e-25

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 105.04  E-value: 2.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  440 SHVFQYTMYTVVAVNGIWILVETFMlQGGNFFSRNVPWSYIVFLTIYGVELLLKTTGLGPV-EYLSSGWNLFDFSVTLFA 518
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYF-QPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKkRYFRSPWNILDFVVVLPS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  519 FLGLMAlaFNMEPFYFIVVLRPLQLLRLFKLKKR---YRNVLDTMFELFPRMASLGLTLLIFYYCFAIVGMEFFAGVVyp 595
Cdd:pfam00520  80 LISLVL--SSVGSLSGLRVLRLLRLLRLLRLIRRlegLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  596 nccntstvadsYRWVNHTVGNktvveegyyylNNFDNILNSFVTLFELTVVNDWYIIMEGVT-SETTHWSRLYFMIFYIV 674
Cdd:pfam00520 156 -----------KTWENPDNGR-----------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIdGKGEFWAYIYFVSFIIL 213
                         250
                  ....*....|....*...
gi 513211346  675 TMVVMT-IIVAFILEAFV 691
Cdd:pfam00520 214 GGFLLLnLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
142-330 7.72e-17

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 80.77  E-value: 7.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  142 TLELFALMVVVFELSMKMRWLGF-HTFIRHKRTMVKTCVLLVQFIEAIVVLVRQTSHVRITRALRCIFLVDC-RYCGAVR 219
Cdd:pfam00520  37 ILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLISLVLSSVGSLSGLRVLRLLRLLRLLRLiRRLEGLR 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  220 RNLRQIFQSLPPFIDILLLLLFFMVIFAILGFYLF--------SPNHSDPYFNTLENSLVNLFVLLTTSNFPDVMMPSYA 291
Cdd:pfam00520 117 TLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFggklktweNPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID 196
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 513211346  292 R--NPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK 330
Cdd:pfam00520 197 GkgEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
440-691 2.93e-25

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 105.04  E-value: 2.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  440 SHVFQYTMYTVVAVNGIWILVETFMlQGGNFFSRNVPWSYIVFLTIYGVELLLKTTGLGPV-EYLSSGWNLFDFSVTLFA 518
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYF-QPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKkRYFRSPWNILDFVVVLPS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  519 FLGLMAlaFNMEPFYFIVVLRPLQLLRLFKLKKR---YRNVLDTMFELFPRMASLGLTLLIFYYCFAIVGMEFFAGVVyp 595
Cdd:pfam00520  80 LISLVL--SSVGSLSGLRVLRLLRLLRLLRLIRRlegLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  596 nccntstvadsYRWVNHTVGNktvveegyyylNNFDNILNSFVTLFELTVVNDWYIIMEGVT-SETTHWSRLYFMIFYIV 674
Cdd:pfam00520 156 -----------KTWENPDNGR-----------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIdGKGEFWAYIYFVSFIIL 213
                         250
                  ....*....|....*...
gi 513211346  675 TMVVMT-IIVAFILEAFV 691
Cdd:pfam00520 214 GGFLLLnLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
142-330 7.72e-17

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 80.77  E-value: 7.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  142 TLELFALMVVVFELSMKMRWLGF-HTFIRHKRTMVKTCVLLVQFIEAIVVLVRQTSHVRITRALRCIFLVDC-RYCGAVR 219
Cdd:pfam00520  37 ILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLISLVLSSVGSLSGLRVLRLLRLLRLLRLiRRLEGLR 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  220 RNLRQIFQSLPPFIDILLLLLFFMVIFAILGFYLF--------SPNHSDPYFNTLENSLVNLFVLLTTSNFPDVMMPSYA 291
Cdd:pfam00520 117 TLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFggklktweNPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID 196
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 513211346  292 R--NPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK 330
Cdd:pfam00520 197 GkgEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
440-691 2.93e-25

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 105.04  E-value: 2.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  440 SHVFQYTMYTVVAVNGIWILVETFMlQGGNFFSRNVPWSYIVFLTIYGVELLLKTTGLGPV-EYLSSGWNLFDFSVTLFA 518
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYF-QPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKkRYFRSPWNILDFVVVLPS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  519 FLGLMAlaFNMEPFYFIVVLRPLQLLRLFKLKKR---YRNVLDTMFELFPRMASLGLTLLIFYYCFAIVGMEFFAGVVyp 595
Cdd:pfam00520  80 LISLVL--SSVGSLSGLRVLRLLRLLRLLRLIRRlegLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  596 nccntstvadsYRWVNHTVGNktvveegyyylNNFDNILNSFVTLFELTVVNDWYIIMEGVT-SETTHWSRLYFMIFYIV 674
Cdd:pfam00520 156 -----------KTWENPDNGR-----------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIdGKGEFWAYIYFVSFIIL 213
                         250
                  ....*....|....*...
gi 513211346  675 TMVVMT-IIVAFILEAFV 691
Cdd:pfam00520 214 GGFLLLnLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
142-330 7.72e-17

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 80.77  E-value: 7.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  142 TLELFALMVVVFELSMKMRWLGF-HTFIRHKRTMVKTCVLLVQFIEAIVVLVRQTSHVRITRALRCIFLVDC-RYCGAVR 219
Cdd:pfam00520  37 ILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLISLVLSSVGSLSGLRVLRLLRLLRLLRLiRRLEGLR 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 513211346  220 RNLRQIFQSLPPFIDILLLLLFFMVIFAILGFYLF--------SPNHSDPYFNTLENSLVNLFVLLTTSNFPDVMMPSYA 291
Cdd:pfam00520 117 TLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFggklktweNPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID 196
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 513211346  292 R--NPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK 330
Cdd:pfam00520 197 GkgEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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