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Conserved domains on  [gi|528507385|ref|XP_005173679|]
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growth arrest-specific protein 1-like [Danio rerio]

Protein Classification

GDNF domain-containing protein( domain architecture ID 10658247)

GDNF domain-containing protein similar to Homo sapiens growth arrest-specific protein 1 (GAS-1), which is a specific growth arrest protein involved in growth suppression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 111-188 1.23e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 48.02  E-value: 1.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528507385   111 CTEARQRCEEEPRCQESLNAYLSRCGQLFNG---RKCSSRCKSTIEELLFMPNGV----LLNQCVCDGLERPFCEVVK-Q 182
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSscpGENSEACLRAYCGLALRPFYDdnssVLLFCTCAGNRDEECLEFRrL 80


                   ....*.
gi 528507385   183 NMAKLC 188
Cdd:smart00907  81 FHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 21-94 4.01e-05

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 41.09  E-value: 4.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528507385    21 CWQALIRCHEERDCELAYNQYLTACDGNIRGS-RKQCPSHCISALIRL----NQTSSGTHLESCDCGI--DVECLRAKRA 93
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSScPGENSEACLRAYCGLalrpFYDDNSSVLLFCTCAGnrDEECLEFRRL 80


                   .
gi 528507385    94 I 94
Cdd:smart00907  81 F 81
 
Name Accession Description Interval E-value
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 111-188 1.23e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 48.02  E-value: 1.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528507385   111 CTEARQRCEEEPRCQESLNAYLSRCGQLFNG---RKCSSRCKSTIEELLFMPNGV----LLNQCVCDGLERPFCEVVK-Q 182
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSscpGENSEACLRAYCGLALRPFYDdnssVLLFCTCAGNRDEECLEFRrL 80


                   ....*.
gi 528507385   183 NMAKLC 188
Cdd:smart00907  81 FHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 21-94 4.01e-05

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 41.09  E-value: 4.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528507385    21 CWQALIRCHEERDCELAYNQYLTACDGNIRGS-RKQCPSHCISALIRL----NQTSSGTHLESCDCGI--DVECLRAKRA 93
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSScPGENSEACLRAYCGLalrpFYDDNSSVLLFCTCAGnrDEECLEFRRL 80


                   .
gi 528507385    94 I 94
Cdd:smart00907  81 F 81
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 111-184 1.04e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 37.12  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528507385  111 CTEARQRCEEEPRCQESLNAYLSRCGQLF---NGRKCSSRCKSTIEELLFM---PNGVLLNQCVCDGL--ERPFCEVVKQ 182
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPescSGCPNPARCLRAYRMTPNYvdnLGTSLLLWCTCKGSgnQDEECEEFRR 80


                  ..
gi 528507385  183 NM 184
Cdd:pfam02351  81 NF 82
 
Name Accession Description Interval E-value
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 111-188 1.23e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 48.02  E-value: 1.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528507385   111 CTEARQRCEEEPRCQESLNAYLSRCGQLFNG---RKCSSRCKSTIEELLFMPNGV----LLNQCVCDGLERPFCEVVK-Q 182
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSscpGENSEACLRAYCGLALRPFYDdnssVLLFCTCAGNRDEECLEFRrL 80


                   ....*.
gi 528507385   183 NMAKLC 188
Cdd:smart00907  81 FHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 21-94 4.01e-05

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 41.09  E-value: 4.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528507385    21 CWQALIRCHEERDCELAYNQYLTACDGNIRGS-RKQCPSHCISALIRL----NQTSSGTHLESCDCGI--DVECLRAKRA 93
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSSScPGENSEACLRAYCGLalrpFYDDNSSVLLFCTCAGnrDEECLEFRRL 80


                   .
gi 528507385    94 I 94
Cdd:smart00907  81 F 81
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 111-184 1.04e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 37.12  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528507385  111 CTEARQRCEEEPRCQESLNAYLSRCGQLF---NGRKCSSRCKSTIEELLFM---PNGVLLNQCVCDGL--ERPFCEVVKQ 182
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPescSGCPNPARCLRAYRMTPNYvdnLGTSLLLWCTCKGSgnQDEECEEFRR 80


                  ..
gi 528507385  183 NM 184
Cdd:pfam02351  81 NF 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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