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Conserved domains on  [gi|529012090|ref|XP_005226915|]
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transmembrane protein 132A isoform X1 [Bos taurus]

Protein Classification

transmembrane protein 132( domain architecture ID 12174329)

transmembrane protein 132 (TMEM132) such as Rattus norvegicus TMEM132D, also called mature oligodendrocytes transmembrane protein (MOLT), that may serve as a cell-surface marker for oligodendrocyte differentiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 408-751 6.77e-146

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


:

Pssm-ID: 465003  Cd Length: 344  Bit Score: 438.64  E-value: 6.77e-146
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090   408 ELVNTAPLTGVPRRIPVRLVTVDSGGALVEVTEHIGCESANTQVLQVSEACDAVFVSGKESRGALGVRVDFWWRRLRASL 487
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090   488 RMTVWAPLLPLRIEVTDTTLEQVRGWRVPGPAEGAREPEAAGVEEA-ERRARGCRLQYQRAGVRFLVPFAAHPLDGGRrL 566
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGSNKRRPARDSEDEEEdDRKGRGCRLQYQHATVRVLARFVAEDADTGQ-V 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090   567 THLLGPDWLLDVSHLVAPHARVQDPRVASLEGGRVLVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELRVQPVM 646
Cdd:pfam16070  160 SYLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLVS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090   647 GISLALSRGTAHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTLAPAELYDHHDLGLSVSAEEPGAVLPAEEQGAQLR 726
Cdd:pfam16070  240 GLSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWP 319

                          330       340
                   ....*....|....*....|....*
gi 529012090   727 VVVSGAGTEGLPLHVALHPPEPCRR 751
Cdd:pfam16070  320 VVVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 48-168 3.02e-41

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


:

Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 147.75  E-value: 3.02e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090    48 AALGLLDAPEHFRVQQVGRYPPANSSLGSRSETFLLLQPwpRAQPLLRASYPPFATQQVVPPRV-------TEPHQRPVP 120
Cdd:pfam15705    1 VSYQLSNADSAFFLKEANQDLMRNSSLQSRSESFFIYQA--RQPPVLNASYGPFSVEQVVPLELllpssplGSPNKFTFN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 529012090   121 WDVRAVSVEAAVTPAEPHARVLFHLRGQDW--PPGPGSLPCARLHATHPA 168
Cdd:pfam15705   79 WKLRAHILDSRVYSSRPKVQVLFYIAGRDWddYDPSERLPCVRLFAFRET 128
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 839-904 3.37e-27

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


:

Pssm-ID: 464814  Cd Length: 84  Bit Score: 105.84  E-value: 3.37e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 529012090   839 MVPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQRKEPPDGATDPAsPQPHNWVWLGTD 904
Cdd:pfam15706   20 LVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPV-PHSHDWVWLGRE 84
 
Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 408-751 6.77e-146

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 465003  Cd Length: 344  Bit Score: 438.64  E-value: 6.77e-146
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090   408 ELVNTAPLTGVPRRIPVRLVTVDSGGALVEVTEHIGCESANTQVLQVSEACDAVFVSGKESRGALGVRVDFWWRRLRASL 487
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090   488 RMTVWAPLLPLRIEVTDTTLEQVRGWRVPGPAEGAREPEAAGVEEA-ERRARGCRLQYQRAGVRFLVPFAAHPLDGGRrL 566
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGSNKRRPARDSEDEEEdDRKGRGCRLQYQHATVRVLARFVAEDADTGQ-V 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090   567 THLLGPDWLLDVSHLVAPHARVQDPRVASLEGGRVLVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELRVQPVM 646
Cdd:pfam16070  160 SYLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLVS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090   647 GISLALSRGTAHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTLAPAELYDHHDLGLSVSAEEPGAVLPAEEQGAQLR 726
Cdd:pfam16070  240 GLSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWP 319

                          330       340
                   ....*....|....*....|....*
gi 529012090   727 VVVSGAGTEGLPLHVALHPPEPCRR 751
Cdd:pfam16070  320 VVVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 48-168 3.02e-41

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 147.75  E-value: 3.02e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090    48 AALGLLDAPEHFRVQQVGRYPPANSSLGSRSETFLLLQPwpRAQPLLRASYPPFATQQVVPPRV-------TEPHQRPVP 120
Cdd:pfam15705    1 VSYQLSNADSAFFLKEANQDLMRNSSLQSRSESFFIYQA--RQPPVLNASYGPFSVEQVVPLELllpssplGSPNKFTFN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 529012090   121 WDVRAVSVEAAVTPAEPHARVLFHLRGQDW--PPGPGSLPCARLHATHPA 168
Cdd:pfam15705   79 WKLRAHILDSRVYSSRPKVQVLFYIAGRDWddYDPSERLPCVRLFAFRET 128
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 839-904 3.37e-27

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464814  Cd Length: 84  Bit Score: 105.84  E-value: 3.37e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 529012090   839 MVPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQRKEPPDGATDPAsPQPHNWVWLGTD 904
Cdd:pfam15706   20 LVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPV-PHSHDWVWLGRE 84
 
Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 408-751 6.77e-146

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 465003  Cd Length: 344  Bit Score: 438.64  E-value: 6.77e-146
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090   408 ELVNTAPLTGVPRRIPVRLVTVDSGGALVEVTEHIGCESANTQVLQVSEACDAVFVSGKESRGALGVRVDFWWRRLRASL 487
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090   488 RMTVWAPLLPLRIEVTDTTLEQVRGWRVPGPAEGAREPEAAGVEEA-ERRARGCRLQYQRAGVRFLVPFAAHPLDGGRrL 566
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGSNKRRPARDSEDEEEdDRKGRGCRLQYQHATVRVLARFVAEDADTGQ-V 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090   567 THLLGPDWLLDVSHLVAPHARVQDPRVASLEGGRVLVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELRVQPVM 646
Cdd:pfam16070  160 SYLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLVS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090   647 GISLALSRGTAHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTLAPAELYDHHDLGLSVSAEEPGAVLPAEEQGAQLR 726
Cdd:pfam16070  240 GLSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWP 319

                          330       340
                   ....*....|....*....|....*
gi 529012090   727 VVVSGAGTEGLPLHVALHPPEPCRR 751
Cdd:pfam16070  320 VVVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 48-168 3.02e-41

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 147.75  E-value: 3.02e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529012090    48 AALGLLDAPEHFRVQQVGRYPPANSSLGSRSETFLLLQPwpRAQPLLRASYPPFATQQVVPPRV-------TEPHQRPVP 120
Cdd:pfam15705    1 VSYQLSNADSAFFLKEANQDLMRNSSLQSRSESFFIYQA--RQPPVLNASYGPFSVEQVVPLELllpssplGSPNKFTFN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 529012090   121 WDVRAVSVEAAVTPAEPHARVLFHLRGQDW--PPGPGSLPCARLHATHPA 168
Cdd:pfam15705   79 WKLRAHILDSRVYSSRPKVQVLFYIAGRDWddYDPSERLPCVRLFAFRET 128
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 839-904 3.37e-27

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464814  Cd Length: 84  Bit Score: 105.84  E-value: 3.37e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 529012090   839 MVPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQRKEPPDGATDPAsPQPHNWVWLGTD 904
Cdd:pfam15706   20 LVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPV-PHSHDWVWLGRE 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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