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Conserved domains on  [gi|530364865|ref|XP_005245294|]
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methyltransferase-like protein 25B isoform X7 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 133-199 3.47e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam13679:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 138  Bit Score: 74.14  E-value: 3.47e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530364865  133 KKQHEIRRLGELVKKLSDF----TGCTQVVDVGSGQGHLSRFMA-LGLGLMVKSIEGDQRLVERAQRLDQEL 199
Cdd:pfam13679   1 KKLHQVEHLAEFIAPLLKElldeNGPITIVDHGAGKGYLGFILYyLKYGVRVYGIDTRAELVEKANALAQKL 72
PRK13729 super family cl42933
conjugal transfer pilus assembly protein TraB; Provisional
 179-307 8.08e-06

conjugal transfer pilus assembly protein TraB; Provisional


The actual alignment was detected with superfamily member PRK13729:

Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 47.13  E-value: 8.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364865 179 VKSIEGDQRLVERAQRLDQELLQALEKEEKRnpqiCAAGATASGARSPAATESGCPSGPRGPGEPCGGlLQPGSTAC--- 255
Cdd:PRK13729  85 YEEIRRELDVLNKQRGDDQRRIEKLGQDNAA----LAEQVKALGANPVTATGEPVPQMPASPPGPEGE-PQPGNTPVsfp 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530364865 256 PTGGDAYSTGPAAVP-SGTGPFSQVSMLsscPSSVLNSLPETWFWW-----PPRCPWV 307
Cdd:PRK13729 160 PQGSVAVPPPTAFYPgNGVTPPPQVTYQ---SVPVPNRIQRKTFTYnegkkGPSLPYI 214
 
Name Accession Description Interval E-value
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
 133-199 3.47e-16

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 74.14  E-value: 3.47e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530364865  133 KKQHEIRRLGELVKKLSDF----TGCTQVVDVGSGQGHLSRFMA-LGLGLMVKSIEGDQRLVERAQRLDQEL 199
Cdd:pfam13679   1 KKLHQVEHLAEFIAPLLKElldeNGPITIVDHGAGKGYLGFILYyLKYGVRVYGIDTRAELVEKANALAQKL 72
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 179-307 8.08e-06

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 47.13  E-value: 8.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364865 179 VKSIEGDQRLVERAQRLDQELLQALEKEEKRnpqiCAAGATASGARSPAATESGCPSGPRGPGEPCGGlLQPGSTAC--- 255
Cdd:PRK13729  85 YEEIRRELDVLNKQRGDDQRRIEKLGQDNAA----LAEQVKALGANPVTATGEPVPQMPASPPGPEGE-PQPGNTPVsfp 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530364865 256 PTGGDAYSTGPAAVP-SGTGPFSQVSMLsscPSSVLNSLPETWFWW-----PPRCPWV 307
Cdd:PRK13729 160 PQGSVAVPPPTAFYPgNGVTPPPQVTYQ---SVPVPNRIQRKTFTYnegkkGPSLPYI 214
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 139-199 1.78e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 37.69  E-value: 1.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530364865 139 RRLGELVKKLSDFTGctQVVDVGSGQGHLSRFMAlGLGLMVKSIEGDQRLVERAQRLDQEL 199
Cdd:COG2227   12 RRLAALLARLLPAGG--RVLDVGCGTGRLALALA-RRGADVTGVDISPEALEIARERAAEL 69
 
Name Accession Description Interval E-value
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
 133-199 3.47e-16

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 74.14  E-value: 3.47e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530364865  133 KKQHEIRRLGELVKKLSDF----TGCTQVVDVGSGQGHLSRFMA-LGLGLMVKSIEGDQRLVERAQRLDQEL 199
Cdd:pfam13679   1 KKLHQVEHLAEFIAPLLKElldeNGPITIVDHGAGKGYLGFILYyLKYGVRVYGIDTRAELVEKANALAQKL 72
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 179-307 8.08e-06

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 47.13  E-value: 8.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530364865 179 VKSIEGDQRLVERAQRLDQELLQALEKEEKRnpqiCAAGATASGARSPAATESGCPSGPRGPGEPCGGlLQPGSTAC--- 255
Cdd:PRK13729  85 YEEIRRELDVLNKQRGDDQRRIEKLGQDNAA----LAEQVKALGANPVTATGEPVPQMPASPPGPEGE-PQPGNTPVsfp 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530364865 256 PTGGDAYSTGPAAVP-SGTGPFSQVSMLsscPSSVLNSLPETWFWW-----PPRCPWV 307
Cdd:PRK13729 160 PQGSVAVPPPTAFYPgNGVTPPPQVTYQ---SVPVPNRIQRKTFTYnegkkGPSLPYI 214
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 139-199 1.78e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 37.69  E-value: 1.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530364865 139 RRLGELVKKLSDFTGctQVVDVGSGQGHLSRFMAlGLGLMVKSIEGDQRLVERAQRLDQEL 199
Cdd:COG2227   12 RRLAALLARLLPAGG--RVLDVGCGTGRLALALA-RRGADVTGVDISPEALEIARERAAEL 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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