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Conserved domains on  [gi|530374481|ref|XP_005247446|]
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immunoglobulin-like domain-containing receptor 1 isoform X2 [Homo sapiens]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
43-178 6.21e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam07686:

Pssm-ID: 448366  Cd Length: 109  Bit Score: 39.36  E-value: 6.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374481   43 TERYVT--LFASIILKCDYTTSAQLQDVVVTWrfksfCKDPifdyysasyqaalslgqdpsndcNDNQREVRIVAQRRGQ 120
Cdd:pfam07686   2 TPREVTvaLGGSVTLPCTYSSSMSEASTSVYW-----YRQP-----------------------PGKGPTFLIAYYSNGS 53
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530374481  121 NEPVLGVDYRQRKITIQNRADLVINEVMWWDHGVYYCTIeaPGDTSGDPDKEVKLIVL 178
Cdd:pfam07686  54 EEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDSGTYTCAV--IPSGEGVFGKGTRLTVL 109
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
43-178 6.21e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 429596  Cd Length: 109  Bit Score: 39.36  E-value: 6.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374481   43 TERYVT--LFASIILKCDYTTSAQLQDVVVTWrfksfCKDPifdyysasyqaalslgqdpsndcNDNQREVRIVAQRRGQ 120
Cdd:pfam07686   2 TPREVTvaLGGSVTLPCTYSSSMSEASTSVYW-----YRQP-----------------------PGKGPTFLIAYYSNGS 53
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530374481  121 NEPVLGVDYRQRKITIQNRADLVINEVMWWDHGVYYCTIeaPGDTSGDPDKEVKLIVL 178
Cdd:pfam07686  54 EEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDSGTYTCAV--IPSGEGVFGKGTRLTVL 109
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
43-178 6.21e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 429596  Cd Length: 109  Bit Score: 39.36  E-value: 6.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530374481   43 TERYVT--LFASIILKCDYTTSAQLQDVVVTWrfksfCKDPifdyysasyqaalslgqdpsndcNDNQREVRIVAQRRGQ 120
Cdd:pfam07686   2 TPREVTvaLGGSVTLPCTYSSSMSEASTSVYW-----YRQP-----------------------PGKGPTFLIAYYSNGS 53
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530374481  121 NEPVLGVDYRQRKITIQNRADLVINEVMWWDHGVYYCTIeaPGDTSGDPDKEVKLIVL 178
Cdd:pfam07686  54 EEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDSGTYTCAV--IPSGEGVFGKGTRLTVL 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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