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Conserved domains on  [gi|1370514206|ref|XP_005251948|]
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cip1-interacting zinc finger protein isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 149-458 7.24e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 7.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  149 ATLGNLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRk 228
Cdd:PHA03247  2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA- 2768

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  229 dsssqtmpvedkSDPPEGSEEAAEPRMDTPEDQDLPPCPEDiAKEKRTPAPEPEPCEAselPAKRLRSSEEPTEKEPPgq 308
Cdd:PHA03247  2769 ------------PAPPAAPAAGPPRRLTRPAVASLSESRES-LPSPWDPADPPAAVLA---PAAALPPAASPAGPLPP-- 2830

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  309 lqvkaQPQARMTVPKQTQTPDLLPEALEAQVLP----RFQPRVLQVQAQVQSQTQPRIPS-TDTQVQPKLQKQAQTQTSP 383
Cdd:PHA03247  2831 -----PTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQP 2905

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370514206  384 EHLVLQqkqvqpqlqqeaEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVV 458
Cdd:PHA03247  2906 ERPPQP------------QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 662-686 1.27e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 42.54  E-value: 1.27e-05
                          10        20
                  ....*....|....*....|....*
gi 1370514206 662 FCTVCNRYFKTPRKFVEHVKSQGHK 686
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 568-597 5.01e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.39  E-value: 5.01e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370514206  568 QFFCYICKASCSSQQEFQDHMSEPQHQQRL 597
Cdd:smart00451   3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
UFD2 super family cl40793
U1-like Zn-finger-containing protein [General function prediction only];
642-693 4.70e-03

U1-like Zn-finger-containing protein [General function prediction only];


The actual alignment was detected with superfamily member COG5112:

Pssm-ID: 227443  Cd Length: 126  Bit Score: 38.14  E-value: 4.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 642 DLIQHRRTQDHKIAKQSLRP--------FCTVCNRYFKTPRKFVEHVKSQGHKDKAKELK 693
Cdd:COG5112    29 DQIKNDLSTKESQKKLPYDPelpglgqhYCIECARYFITEKALMEHKKGKVHKRRAKELR 88
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 149-458 7.24e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 7.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  149 ATLGNLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRk 228
Cdd:PHA03247  2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA- 2768

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  229 dsssqtmpvedkSDPPEGSEEAAEPRMDTPEDQDLPPCPEDiAKEKRTPAPEPEPCEAselPAKRLRSSEEPTEKEPPgq 308
Cdd:PHA03247  2769 ------------PAPPAAPAAGPPRRLTRPAVASLSESRES-LPSPWDPADPPAAVLA---PAAALPPAASPAGPLPP-- 2830

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  309 lqvkaQPQARMTVPKQTQTPDLLPEALEAQVLP----RFQPRVLQVQAQVQSQTQPRIPS-TDTQVQPKLQKQAQTQTSP 383
Cdd:PHA03247  2831 -----PTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQP 2905

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370514206  384 EHLVLQqkqvqpqlqqeaEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVV 458
Cdd:PHA03247  2906 ERPPQP------------QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 662-686 1.27e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 42.54  E-value: 1.27e-05
                          10        20
                  ....*....|....*....|....*
gi 1370514206 662 FCTVCNRYFKTPRKFVEHVKSQGHK 686
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 264-476 3.51e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.72  E-value: 3.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 264 PPCPEDIAKEKRTPAPEPE---PCEASELPAKRLRSSEEP-TEKEPPGQLQVKA--------QPQARMTVPKQTQTPDLL 331
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQyqyASQQSQQPSKPVRTGYEKyKEPEPIPDLQVDAslwgvapkKAAAPAPAPQPAAQPASL 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 332 P---------EALEAQVlpRFQPRVLQVQAQVQSQTQPripstdtqVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAE 402
Cdd:pfam09770 187 PapsrkmmslEEVEAAM--RAQAKKPAQQPAPAPAQPP--------AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQH 256

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370514206 403 PQKQVQPQVHtQAQPSVQPqehPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVVVHVCGLEMPPDAVEAGGG 476
Cdd:pfam09770 257 PGQGHPVTIL-QRPQSPQP---DPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQP 326
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 568-597 5.01e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.39  E-value: 5.01e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370514206  568 QFFCYICKASCSSQQEFQDHMSEPQHQQRL 597
Cdd:smart00451   3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
UFD2 COG5112
U1-like Zn-finger-containing protein [General function prediction only];
642-693 4.70e-03

U1-like Zn-finger-containing protein [General function prediction only];


Pssm-ID: 227443  Cd Length: 126  Bit Score: 38.14  E-value: 4.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 642 DLIQHRRTQDHKIAKQSLRP--------FCTVCNRYFKTPRKFVEHVKSQGHKDKAKELK 693
Cdd:COG5112    29 DQIKNDLSTKESQKKLPYDPelpglgqhYCIECARYFITEKALMEHKKGKVHKRRAKELR 88
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 149-458 7.24e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 7.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  149 ATLGNLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRk 228
Cdd:PHA03247  2690 PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA- 2768

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  229 dsssqtmpvedkSDPPEGSEEAAEPRMDTPEDQDLPPCPEDiAKEKRTPAPEPEPCEAselPAKRLRSSEEPTEKEPPgq 308
Cdd:PHA03247  2769 ------------PAPPAAPAAGPPRRLTRPAVASLSESRES-LPSPWDPADPPAAVLA---PAAALPPAASPAGPLPP-- 2830

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  309 lqvkaQPQARMTVPKQTQTPDLLPEALEAQVLP----RFQPRVLQVQAQVQSQTQPRIPS-TDTQVQPKLQKQAQTQTSP 383
Cdd:PHA03247  2831 -----PTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQP 2905

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370514206  384 EHLVLQqkqvqpqlqqeaEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVV 458
Cdd:PHA03247  2906 ERPPQP------------QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
PHA03247 PHA03247
large tegument protein UL36; Provisional
 160-456 3.77e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 3.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  160 ASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGvPMNPSQFNLSGRnPQKQARTSSSTTPnrkdSSSQTMPVED 239
Cdd:PHA03247  2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG-PATPGGPARPAR-PPTTAGPPAPAPP----AAPAAGPPRR 2782

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  240 KSDPPEGSEEAAEPRMDTPEDQDLPPCPEDIAKEKRTPAPEP---EPCEASELPAKRLRSSEEPTEKEPPGQLQVKAQPQ 316
Cdd:PHA03247  2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPagpLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDV 2862

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  317 ARMTVPKQTQTPDLLPEALEAQVLPRFQ-PRVLQVQAQVQSQtQPRIPSTDTQVQPKLQKQAQTQTSPEhlvlqqkqvqP 395
Cdd:PHA03247  2863 RRRPPSRSPAAKPAAPARPPVRRLARPAvSRSTESFALPPDQ-PERPPQPQAPPPPQPQPQPPPPPQPQ----------P 2931

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514206  396 QLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHT-QPQVSLLAPEQTP 456
Cdd:PHA03247  2932 PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVpQPAPSREAPASST 2993
PHA03247 PHA03247
large tegument protein UL36; Provisional
 161-474 3.63e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 3.63e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  161 SPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSG----------RNPQKQARTSSSTT-PNRKD 229
Cdd:PHA03247  2608 PRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPApgrvsrprraRRLGRAAQASSPPQrPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  230 SSSQTMPVEDKSDPPEGSEEAAEPRMDTPEDQDLPPCPEDIAKEK----RTPAPEPEPcEASELPAKRLRSSEEPTEKEP 305
Cdd:PHA03247  2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASpalpAAPAPPAVP-AGPATPGGPARPARPPTTAGP 2766

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  306 PGqlqvKAQPQARMTVPKQTQT-PDLLPEALEAQVLPrfQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPE 384
Cdd:PHA03247  2767 PA----PAPPAAPAAGPPRRLTrPAVASLSESRESLP--SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  385 HLVLQQKQVQP----------------QLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQ--VSVQPPEQTHEQPHTQPQ 446
Cdd:PHA03247  2841 PPPGPPPPSLPlggsvapggdvrrrppSRSPAAKPAAPARPPVRRLARPAVSRSTESFALppDQPERPPQPQAPPPPQPQ 2920

                          330       340
                   ....*....|....*....|....*...
gi 1370514206  447 VSLLAPEQTPVVVHVCGLEMPPDAVEAG 474
Cdd:PHA03247  2921 PQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 662-686 1.27e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 42.54  E-value: 1.27e-05
                          10        20
                  ....*....|....*....|....*
gi 1370514206 662 FCTVCNRYFKTPRKFVEHVKSQGHK 686
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 264-476 3.51e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.72  E-value: 3.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 264 PPCPEDIAKEKRTPAPEPE---PCEASELPAKRLRSSEEP-TEKEPPGQLQVKA--------QPQARMTVPKQTQTPDLL 331
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQyqyASQQSQQPSKPVRTGYEKyKEPEPIPDLQVDAslwgvapkKAAAPAPAPQPAAQPASL 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 332 P---------EALEAQVlpRFQPRVLQVQAQVQSQTQPripstdtqVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAE 402
Cdd:pfam09770 187 PapsrkmmslEEVEAAM--RAQAKKPAQQPAPAPAQPP--------AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQH 256

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370514206 403 PQKQVQPQVHtQAQPSVQPqehPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVVVHVCGLEMPPDAVEAGGG 476
Cdd:pfam09770 257 PGQGHPVTIL-QRPQSPQP---DPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQP 326
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 160-452 3.70e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.77  E-value: 3.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  160 ASPGLAAPSLTPPQLATPNLQ---QFFPQATRqsllgPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRKDSSSQTMP 236
Cdd:PRK10263   577 AAATVAAPVFSLANSGGPRPQvkeGIGPQLPR-----PKRIRVPTRRELASYGIKLPSQRAAEEKAREAQRNQYDSGDQY 651

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  237 VEDKSDPPEGSEEAAE------PRMDTPEDQDLPPCPEDiakekRTPAPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQ 310
Cdd:PRK10263   652 NDDEIDAMQQDELARQfaqtqqQRYGEQYQHDVPVNAED-----ADAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDD 726

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  311 VKAQPQArmtvpkqtqtpDLLPEALEAqvlPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTS--PEHLVL 388
Cdd:PRK10263   727 FEFSPMK-----------ALLDDGPHE---PLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPvaPQPQYQ 792

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370514206  389 QQKQVQPQLQQEAEPQKQVQPQVHTQaqpsvQPQEhppaQVSVQPPEQTHEQPHT-QPQVSLLAP 452
Cdd:PRK10263   793 QPQQPVAPQPQYQQPQQPVAPQPQYQ-----QPQQ----PVAPQPQYQQPQQPVApQPQDTLLHP 848
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 214-456 5.93e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.07  E-value: 5.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 214 QKQARTSSSTTPNRKDSS-SQTMPVEDKSDPPEGSEEAAEPRmdtPEDQDLPPCPEDIAKEKRTPAPEPEPCEASELPAK 292
Cdd:pfam03154  83 QREKGASDTEEPERATAKkSKTQEISRPNSPSEGEGESSDGR---SVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSD 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 293 RLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQP------------ 360
Cdd:pfam03154 160 SSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhtliqqtptlhp 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 361 -RIPSTDTQVQPKLQKQAQTQTSPEHLVLQQ---KQVQPQLQQEAEP---QKQVQPQVHTQAQPSVQPQEHPPAQVSVqp 433
Cdd:pfam03154 240 qRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgQMPPMPHSLQTGPshmQHPVPPQPFPLTPQSSQSQVPPGPSPAA-- 317

                         250       260
                  ....*....|....*....|...
gi 1370514206 434 PEQTHEQPHTQPQVSLLAPEQTP 456
Cdd:pfam03154 318 PGQSQQRIHTPPSQSQLQSQQPP 340
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 300-458 2.53e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.08  E-value: 2.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  300 PTEKEPPGQLQVKAQPqarmtVP-KQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQ 378
Cdd:PRK10263   347 ASVDVPPAQPTVAWQP-----VPgPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYY 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  379 TQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVsvqPPEQTHEQPHTQPQVSLLAPEqtPVV 458
Cdd:PRK10263   422 APAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPA---AQEPLYQQPQPVEQQPVVEPE--PVV 496
PHA03247 PHA03247
large tegument protein UL36; Provisional
 171-567 4.78e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 4.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  171 PPQLATPNLQqffPQATRQSLlgPPPVGVPmnpsqfnlsgrNPQKQARTSSSTTPNRKDSSSQTMPVEDKSDPPEGSEEA 250
Cdd:PHA03247  2551 PPPPLPPAAP---PAAPDRSV--PPPRPAP-----------RPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPP 2614

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  251 AEPRMDTPEDQDLPPCPEDIAKEKRTPAPEPEPceaselPAKRLRSSEEPTEKEPPGQLQVKAQPqARMTVPKQTQTPDL 330
Cdd:PHA03247  2615 SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVP------PPERPRDDPAPGRVSRPRRARRLGRA-AQASSPPQRPRRRA 2687

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  331 LPEA---LEAQVLPRFQPRvlqvqaQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQV 407
Cdd:PHA03247  2688 ARPTvgsLTSLADPPPPPP------TPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPP 2761

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  408 QPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPqvSLLAPEQTPVVVHVCGLEMPPDAVEAGGGMEKTLPEPVGT 487
Cdd:PHA03247  2762 TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLP--SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  488 QVSMEEIQNESACGLDVGECENRAREMPgvwgaggslkvtilqssdSRAFSTVPLTPvPRPSDSVSSTPAATSTPSKQAL 567
Cdd:PHA03247  2840 PPPPGPPPPSLPLGGSVAPGGDVRRRPP------------------SRSPAAKPAAP-ARPPVRRLARPAVSRSTESFAL 2900
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 568-597 5.01e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.39  E-value: 5.01e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370514206  568 QFFCYICKASCSSQQEFQDHMSEPQHQQRL 597
Cdd:smart00451   3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
PRK10927 PRK10927
cell division protein FtsN;
290-456 1.45e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 41.59  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 290 PAKRLRSSEEPTEKEPpgQLQVKAQPQARMTVPKQTQtpdLLPEalEAQVLPRFQPRVLQVQAQVQSQtqPRIPSTDTQV 369
Cdd:PRK10927   79 PEERWRYIKELESRQP--GVRAPTEPSAGGEVKTPEQ---LTPE--QRQLLEQMQADMRQQPTQLVEV--PWNEQTPEQR 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 370 QPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSL 449
Cdd:PRK10927  150 QQTLQRQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQPYQDLLQTPAHTTAQSKPQQAAPV 229


                  ....*..
gi 1370514206 450 LAPEQTP 456
Cdd:PRK10927  230 TRAADAP 236
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
197-382 1.55e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 42.34  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 197 VGVPMNPSQFNLSGRNPQKQARTSSSttpnrkdSSSQTMPVEDKSDPP-EGSEEAAEPRMDTPedqdlpPCPEDIAKEKR 275
Cdd:PRK14960  368 VSEPVQQNGQAEVGLNSQAQTAQEIT-------PVSAVQPVEVISQPAmVEPEPEPEPEPEPE------PEPEPEPEPEP 434

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 276 TPAPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTP-DLLPEALEAQVLPRF--QPRVLQVQA 352
Cdd:PRK14960  435 EPEPEPEPQPNQDLMVFDPNHHELIGLESAVVQETVSVLEEDFIPVPEQKLVQvQAETQVKQIEPEPAStaEPIGLFEAS 514

                         170       180       190
                  ....*....|....*....|....*....|
gi 1370514206 353 QVQSQTQPRIPSTDTQVQPKLQKQAQTQTS 382
Cdd:PRK14960  515 SAEFSLAQDTSAYDLVSEPVIEQQSLVQAE 544
rne PRK10811
ribonuclease E; Reviewed
 257-476 2.65e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 41.56  E-value: 2.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  257 TPEDQDLPPCPEDIAKEKRTPAPEPEPCEASELPAKRLRSSEEPTEKEPPgqlQVKAQPQARMTVPKQTQTPDLlpeale 336
Cdd:PRK10811   849 RPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEP---VVVAEPQPEEVVVVETTHPEV------ 919

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  337 aqvlprfqprvlqVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVHTQAQ 416
Cdd:PRK10811   920 -------------IAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAE 986

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370514206  417 PSVQPQEHPPAQVSVQPP---EQTHEQPH-TQPQVSLLAPEQTPVVVHVCGLEMPPDAVEAGGG 476
Cdd:PRK10811   987 VAAEVETVTAVEPEVAPAqvpEATVEHNHaTAPMTRAPAPEYVPEAPRHSDWQRPTFAFEGKGA 1050
PRK10927 PRK10927
cell division protein FtsN;
277-440 3.20e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 40.82  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 277 PAPEPEPCEASELPAKR--LRSSEEPT---EKEPPGQL-----QVKAQPQARMTvpkqtQTPDLLPEALEAQVLPRFQPR 346
Cdd:PRK10927   77 PKPEERWRYIKELESRQpgVRAPTEPSaggEVKTPEQLtpeqrQLLEQMQADMR-----QQPTQLVEVPWNEQTPEQRQQ 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 347 VLQVQAQVQSQTQPRiPSTDTQVQPKLQKQAQTQTSpehlVLQQKQVQPQLQQEAEPQKQ----VQPQVHTQAQPsvQPQ 422
Cdd:PRK10927  152 TLQRQRQAQQLAEQQ-RLAQQSRTTEQSWQQQTRTS----QAAPVQAQPRQSKPASTQQPyqdlLQTPAHTTAQS--KPQ 224

                         170
                  ....*....|....*...
gi 1370514206 423 EHPPAQVSVQPPEQTHEQ 440
Cdd:PRK10927  225 QAAPVTRAADAPKPTAEK 242
PRK12757 PRK12757
cell division protein FtsN; Provisional
 352-457 3.80e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 40.03  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 352 AQVQSQTQpripSTDTQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVSV 431
Cdd:PRK12757   72 GEVNSPTQ----LTDEQRQLLEQMQADMRQQPTQLSEVPYNEQTPQVPRSTVQIQQQAQQQQPPATTAQPQPVTPPRQTT 147

                          90       100
                  ....*....|....*....|....*.
gi 1370514206 432 QPPEQTHEQPHTQPQvslLAPEQTPV 457
Cdd:PRK12757  148 APVQPQTPAPVRTQP---AAPVTQAV 170
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 214-457 4.01e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 4.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 214 QKQARTSSSTTPNRKDSSSQTMPVEDKSDPPEGSEE--AAEPRMDTPEDQ--DLPPCPEDIAKEKRTPAPEPEPCEASEL 289
Cdd:pfam03154 105 QEISRPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDnrSTSPSIPSPQDNesDSDSSAQQQILQTQPPVLQAQSGAASPP 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 290 PAKRLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQPRIPST---D 366
Cdd:pfam03154 185 SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQvspQ 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 367 TQVQPKLQKQAQT-----QTSPEHLVLQQKQVQPQLQQEAEpQKQVQPQVHTQAQ-PSVQPQEHPPAQVSV---QPPEQT 437
Cdd:pfam03154 265 PLPQPSLHGQMPPmphslQTGPSHMQHPVPPQPFPLTPQSS-QSQVPPGPSPAAPgQSQQRIHTPPSQSQLqsqQPPREQ 343

                         250       260
                  ....*....|....*....|
gi 1370514206 438 HEQPHTQPQVSLLAPEQTPV 457
Cdd:pfam03154 344 PLPPAPLSMPHIKPPPTTPI 363
UFD2 COG5112
U1-like Zn-finger-containing protein [General function prediction only];
642-693 4.70e-03

U1-like Zn-finger-containing protein [General function prediction only];


Pssm-ID: 227443  Cd Length: 126  Bit Score: 38.14  E-value: 4.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 642 DLIQHRRTQDHKIAKQSLRP--------FCTVCNRYFKTPRKFVEHVKSQGHKDKAKELK 693
Cdd:COG5112    29 DQIKNDLSTKESQKKLPYDPelpglgqhYCIECARYFITEKALMEHKKGKVHKRRAKELR 88
PRK12757 PRK12757
cell division protein FtsN; Provisional
 355-444 6.21e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 39.26  E-value: 6.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206 355 QSQTQPRIPSTDTQVQPKLQKQAQTQTSPehlvlqqkqvqpqlQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPP 434
Cdd:PRK12757  108 NEQTPQVPRSTVQIQQQAQQQQPPATTAQ--------------PQPVTPPRQTTAPVQPQTPAPVRTQPAAPVTQAVEAP 173

                          90
                  ....*....|
gi 1370514206 435 EQTHEQPHTQ 444
Cdd:PRK12757  174 KVEAEKEKEQ 183
PHA03247 PHA03247
large tegument protein UL36; Provisional
 79-371 8.52e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 8.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206   79 PQAPLPMAVSRGLPPQQPQQPLLNLQGTNSASLLNGSMLQRALLLQQLQGLDqfAMPPAtyDTAGLTMPTATLGNLRGYG 158
Cdd:PHA03247  2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA--PAPPA--APAAGPPRRLTRPAVASLS 2792

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  159 MASPGLAAPS--LTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSqfnLSGRNPQKQARTSSSTTP----NRKDSSS 232
Cdd:PHA03247  2793 ESRESLPSPWdpADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP---PPPGPPPPSLPLGGSVAPggdvRRRPPSR 2869

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514206  233 QTMPVEDKSDPPEGSEEAAEPRMDTPEDQDLPPcpediakekrtpaPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQVK 312
Cdd:PHA03247  2870 SPAAKPAAPARPPVRRLARPAVSRSTESFALPP-------------DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP 2936

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1370514206  313 AQPQARmtvPKQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQP 371
Cdd:PHA03247  2937 PRPQPP---LAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASS 2992
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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