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Conserved domains on  [gi|530395746|ref|XP_005253166|]
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tubby protein homolog isoform X1 [Homo sapiens]

Protein Classification

tubby family protein( domain architecture ID 11242254)

tubby (TUB) family protein similar to Mus musculus tubby protein that binds to membranes containing phosphatidylinositol 4,5-bisphosphate and functions in signal transduction from heterotrimeric G protein-coupled receptors

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Tub pfam01167
Tub family;
298-543 6.62e-139

Tub family;


:

Pssm-ID: 460094  Cd Length: 251  Bit Score: 401.96  E-value: 6.62e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746  298 LRPAPQGITIKCRITRDKKGMdrGMYPTYFLHLDREDGKK-VFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRS 376
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPGDGgKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746  377 NLMGTKFTVYDN-----GVNPQKASSSTLESG--TLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEH 449
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKvsPGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSES 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746  450 eTLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLC 529
Cdd:pfam01167 159 -SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237

                         250
                  ....*....|....
gi 530395746  530 ALQAFAIALSSFDS 543
Cdd:pfam01167 238 AFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 71-279 1.67e-57

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


:

Pssm-ID: 465092  Cd Length: 196  Bit Score: 190.40  E-value: 1.67e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746   71 RQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASak 150
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIYHVQEAAPRSAKRSGAHAALGTQG-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746  151 rtkaaataggqggaarkekkGKHKGTSGPAA-LAEDKSEAQGPVQILTVGQS----DHAQDAGETAAGGGERPSGQDLRA 225
Cdd:pfam16322  79 --------------------GDGKGIDGPAAfLTEEPQDSGSELQILSVGDSptspPPDEELQEPGASGEEESSKQDLGD 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530395746  226 TMQRKGISSSMS-FDEDEEDEEENSSSSSQLNSN---TRPSSATSRKSVREAASAPSP 279
Cdd:pfam16322 139 EMQKKGISSSMNfDEEEEDEEEESSSRSSQLNSNeesTRPSSATSKKSSSEVGSSPSP 196
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
298-543 6.62e-139

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 401.96  E-value: 6.62e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746  298 LRPAPQGITIKCRITRDKKGMdrGMYPTYFLHLDREDGKK-VFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRS 376
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPGDGgKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746  377 NLMGTKFTVYDN-----GVNPQKASSSTLESG--TLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEH 449
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKvsPGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSES 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746  450 eTLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLC 529
Cdd:pfam01167 159 -SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237

                         250
                  ....*....|....
gi 530395746  530 ALQAFAIALSSFDS 543
Cdd:pfam01167 238 AFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 71-279 1.67e-57

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 190.40  E-value: 1.67e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746   71 RQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASak 150
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIYHVQEAAPRSAKRSGAHAALGTQG-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746  151 rtkaaataggqggaarkekkGKHKGTSGPAA-LAEDKSEAQGPVQILTVGQS----DHAQDAGETAAGGGERPSGQDLRA 225
Cdd:pfam16322  79 --------------------GDGKGIDGPAAfLTEEPQDSGSELQILSVGDSptspPPDEELQEPGASGEEESSKQDLGD 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530395746  226 TMQRKGISSSMS-FDEDEEDEEENSSSSSQLNSN---TRPSSATSRKSVREAASAPSP 279
Cdd:pfam16322 139 EMQKKGISSSMNfDEEEEDEEEESSSRSSQLNSNeesTRPSSATSKKSSSEVGSSPSP 196
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
298-543 6.62e-139

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 401.96  E-value: 6.62e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746  298 LRPAPQGITIKCRITRDKKGMdrGMYPTYFLHLDREDGKK-VFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRS 376
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPGDGgKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746  377 NLMGTKFTVYDN-----GVNPQKASSSTLESG--TLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEH 449
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKvsPGRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSES 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746  450 eTLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLC 529
Cdd:pfam01167 159 -SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237

                         250
                  ....*....|....
gi 530395746  530 ALQAFAIALSSFDS 543
Cdd:pfam01167 238 AFQAFAICLSSFDT 251
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 71-279 1.67e-57

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 190.40  E-value: 1.67e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746   71 RQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASak 150
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEQAPLVESYLSGNSGTIYHVQEAAPRSAKRSGAHAALGTQG-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530395746  151 rtkaaataggqggaarkekkGKHKGTSGPAA-LAEDKSEAQGPVQILTVGQS----DHAQDAGETAAGGGERPSGQDLRA 225
Cdd:pfam16322  79 --------------------GDGKGIDGPAAfLTEEPQDSGSELQILSVGDSptspPPDEELQEPGASGEEESSKQDLGD 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530395746  226 TMQRKGISSSMS-FDEDEEDEEENSSSSSQLNSN---TRPSSATSRKSVREAASAPSP 279
Cdd:pfam16322 139 EMQKKGISSSMNfDEEEEDEEEESSSRSSQLNSNeesTRPSSATSKKSSSEVGSSPSP 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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