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Conserved domains on  [gi|530406156|ref|XP_005254586|]
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uveal autoantigen with coiled-coil domains and ankyrin repeats isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-256 2.69e-38

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.48  E-value: 2.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   11 KNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRN 90
Cdd:COG0666    43 ALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGET 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   91 ALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTIC 170
Cdd:COG0666   123 PLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  171 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGR 250
Cdd:COG0666   203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                  ....*.
gi 530406156  251 ELWKKG 256
Cdd:COG0666   283 LDLLTL 288
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 521-1322 1.58e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 95.51  E-value: 1.58e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   521 QLKDLKVKYEGASAEVGKLRNQIKQNEMivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL- 599
Cdd:TIGR02168  214 RYKELKAELRELELALLVLRLEELREEL--EELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELy 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   600 ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhvKPEEHEQVKSRLEqksgELGK 679
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE--LKEELESLEAELE----ELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   680 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEME 759
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEEL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   760 KLLLEndslsKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVP-- 837
Cdd:TIGR02168  446 EEELE-----ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLsg 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   838 --------VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKD---------------KNEILKRNLENTQNQI 894
Cdd:TIGR02168  521 ilgvlselISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNElgrvtflpldsikgtEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   895 KAEYISLAEHEAK----MSSLSQSMRKVQD-SNAEILANYRKGQEEIVTL------------------HAEIKAQKKELD 951
Cdd:TIGR02168  601 LGVAKDLVKFDPKlrkaLSYLLGGVLVVDDlDNALELAKKLRPGYRIVTLdgdlvrpggvitggsaktNSSILERRREIE 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   952 TIQECIkvkyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1031
Cdd:TIGR02168  681 ELEEKI----------EELEEKIAELEKALAELRKELEEL----EEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1032 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1111
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1112 KSMQRCYEKEQQTVTKLHQLLE-----------NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1180
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEelsedieslaaEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1181 QSEVQNTKQALKKLETRevvdLSKYKATKSDLETQISSLNEKLANL-NRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1259
Cdd:TIGR02168  907 ESKRSELRRELEELREK----LAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530406156  1260 ----------QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDV-ERLKQALNGLSQLTYTSG 1322
Cdd:TIGR02168  983 elgpvnlaaiEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERFKDTfDQVNENFQRVFPKLFGGG 1056
PRK03918 super family cl35229
DNA double-strand break repair ATPase Rad50;
286-708 9.71e-07

DNA double-strand break repair ATPase Rad50;


The actual alignment was detected with superfamily member PRK03918:

Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 53.53  E-value: 9.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  286 LEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFEsdhlgsgshfsn 365
Cdd:PRK03918  298 LSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYE------------ 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  366 rKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELslpsqtsysENEIlkKELEAMRTFCESAKQDRLKLQNELah 445
Cdd:PRK03918  366 -EAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEI---------EEEI--SKITARIGELKKEIKELKKAIEEL-- 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  446 KVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAA-SGNHRLTEELKDQLKD 524
Cdd:PRK03918  432 KKAKGKCPVCGRELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESElIKLKELAEQLKELEEK 511

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  525 LKV-----------KYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQ---KELSMCEMEREKKGRK-VTEME 589
Cdd:PRK03918  512 LKKynleelekkaeEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDeleEELAELLKELEELGFEsVEELE 591

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  590 GQAKELsaklalsipaEKFENMKSSLSN---EVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVK---PEEH 663
Cdd:PRK03918  592 ERLKEL----------EPFYNEYLELKDaekELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKkysEEEY 661

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 530406156  664 EQVKSRLEQKSGELGKKITELtlknQTLQKEIEKVYLDNKLLKEQ 708
Cdd:PRK03918  662 EELREEYLELSRELAGLRAEL----EELEKRREEIKKTLEKLKEE 702
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-256 2.69e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.48  E-value: 2.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   11 KNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRN 90
Cdd:COG0666    43 ALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGET 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   91 ALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTIC 170
Cdd:COG0666   123 PLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  171 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGR 250
Cdd:COG0666   203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                  ....*.
gi 530406156  251 ELWKKG 256
Cdd:COG0666   283 LDLLTL 288
PHA03095 PHA03095
ankyrin-like protein; Provisional
 35-218 1.58e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 93.55  E-value: 1.58e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   35 EKVTSILAKKGVNPGKLDVEGRSVFHV-VTSKG-NLECLNAILIHGVDITTSDTAGRNALHLAAKYGH--ALCLQKLLQY 110
Cdd:PHA03095  132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  111 NCPTEHADLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNR 188
Cdd:PHA03095  212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                         170       180       190
                  ....*....|....*....|....*....|
gi 530406156  189 TALMLGCEYGCRDAVEVLIKNGADISLLDA 218
Cdd:PHA03095  292 TPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 521-1322 1.58e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 95.51  E-value: 1.58e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   521 QLKDLKVKYEGASAEVGKLRNQIKQNEMivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL- 599
Cdd:TIGR02168  214 RYKELKAELRELELALLVLRLEELREEL--EELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELy 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   600 ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhvKPEEHEQVKSRLEqksgELGK 679
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE--LKEELESLEAELE----ELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   680 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEME 759
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEEL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   760 KLLLEndslsKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVP-- 837
Cdd:TIGR02168  446 EEELE-----ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLsg 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   838 --------VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKD---------------KNEILKRNLENTQNQI 894
Cdd:TIGR02168  521 ilgvlselISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNElgrvtflpldsikgtEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   895 KAEYISLAEHEAK----MSSLSQSMRKVQD-SNAEILANYRKGQEEIVTL------------------HAEIKAQKKELD 951
Cdd:TIGR02168  601 LGVAKDLVKFDPKlrkaLSYLLGGVLVVDDlDNALELAKKLRPGYRIVTLdgdlvrpggvitggsaktNSSILERRREIE 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   952 TIQECIkvkyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1031
Cdd:TIGR02168  681 ELEEKI----------EELEEKIAELEKALAELRKELEEL----EEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1032 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1111
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1112 KSMQRCYEKEQQTVTKLHQLLE-----------NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1180
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEelsedieslaaEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1181 QSEVQNTKQALKKLETRevvdLSKYKATKSDLETQISSLNEKLANL-NRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1259
Cdd:TIGR02168  907 ESKRSELRRELEELREK----LAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530406156  1260 ----------QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDV-ERLKQALNGLSQLTYTSG 1322
Cdd:TIGR02168  983 elgpvnlaaiEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERFKDTfDQVNENFQRVFPKLFGGG 1056
Ank_2 pfam12796
Ankyrin repeats (3 copies);
92-184 2.37e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.32  E-value: 2.37e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156    92 LHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDvDGRTPLVLATQMSRPTICQ 171
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 530406156   172 LLIDRGADVNSRD 184
Cdd:pfam12796   79 LLLEKGADINVKD 91
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
606-1195 2.12e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 78.57  E-value: 2.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  606 EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAqhvKPEEHEQVKSRLEQKSGELGKKITELT 685
Cdd:PRK03918  182 EKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK---ELEELKEEIEELEKELESLEGSKRKLE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  686 LKNQTLQKEIEKVYLDNKLLKEQAhnltiemknhyvplKVSEDMKKSHDAIIddlnrKLLDVTQKYTEKKLEMEKLLlen 765
Cdd:PRK03918  259 EKIRELEERIEELKKEIEELEEKV--------------KELKELKEKAEEYI-----KLSEFYEEYLDELREIEKRL--- 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  766 DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCgEDQEKIHALTSENTNLKKMMSNQyvpvktheevk 845
Cdd:PRK03918  317 SRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERH-ELYEEAKAKKEELERLKKRLTGL----------- 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  846 mtlndTLAKTNRELLDVKKKFEDINQEFVKIKDKneilKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMrkVQDSNAEI 925
Cdd:PRK03918  385 -----TPEKLEKELEELEKAKEEIEEEISKITAR----IGELKKEIKELKKAIEELKKAKGKCPVCGREL--TEEHRKEL 453

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  926 LANYRKGQEEIVTLHAEIKAQKKELdtiqECIKVKYAPIVSFEECERKFKATEKELKDqLSEQTQKYSVSE-----EEVK 1000
Cdd:PRK03918  454 LEEYTAELKRIEKELKEIEEKERKL----RKELRELEKVLKKESELIKLKELAEQLKE-LEEKLKKYNLEElekkaEEYE 528

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1001 KNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQK-YTEVKNVKEKLVE---------ENA 1070
Cdd:PRK03918  529 KLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgFESVEELEERLKElepfyneylELK 608

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1071 KQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQqtvtklHQLLENQKNSsvplaehlqike 1150
Cdd:PRK03918  609 DAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEE------YEELREEYLE------------ 670

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 530406156 1151 aFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLE 1195
Cdd:PRK03918  671 -LSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELE 714
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 418-1187 7.04e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 67.07  E-value: 7.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   418 LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLedalkdvQKRMYESEGKVKQMQTHFL 497
Cdd:pfam15921  122 MQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQL-------RKMMLSHEGVLQEIRSILV 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   498 ALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIE-----ENKRLQKELS 572
Cdd:pfam15921  195 DFEEASGKKIYEHDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIElllqqHQDRIEQLIS 274

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   573 MCEMEREKKGRKVTEMEGQAKELSAKLalsipaekfENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA 652
Cdd:pfam15921  275 EHEVEITGLTEKASSARSQANSIQSQL---------EIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIE 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   653 KLAQHVKPEEHEQVKSRLE-----QKSGELGKKITELTLKNQTLQKEIEkvyldnkLLKEQAHNLTiemknhyvplkvse 727
Cdd:pfam15921  346 ELEKQLVLANSELTEARTErdqfsQESGNLDDQLQKLLADLHKREKELS-------LEKEQNKRLW-------------- 404

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   728 DMKKSHDAIIDDLNRKLldvtqkytekklemeklllenDSLSKDVSRLETVfvppekhekeIIALKSNIV-ELKKQLSEL 806
Cdd:pfam15921  405 DRDTGNSITIDHLRREL---------------------DDRNMEVQRLEAL----------LKAMKSECQgQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   807 KKKcGEDQEKIHALTSENTNLKKMMSnqyvpvKTHEEV---KMTLND---TLAKTNRELLDVKKKFEDINQEFVKIKDKN 880
Cdd:pfam15921  454 QGK-NESLEKVSSLTAQLESTKEMLR------KVVEELtakKMTLESserTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   881 EILKRNLENTQNQikAEYISLAEHEAKMSSLSQSMRkvqDSNAEILANYRKGQEEIVTLHAEIK-AQKKELDTIQECIKV 959
Cdd:pfam15921  527 DLKLQELQHLKNE--GDHLRNVQTECEALKLQMAEK---DKVIEILRQQIENMTQLVGQHGRTAgAMQVEKAQLEKEIND 601

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   960 KYAPIVSFEECERKFKATEKELKDQLS----EQTQKYSVSEEE---VKKNKQENDKLKKEIFTLQKDLRDKTVLIE---- 1028
Cdd:pfam15921  602 RRLELQEFKILKDKKDAKIRELEARVSdlelEKVKLVNAGSERlraVKDIKQERDQLLNEVKTSRNELNSLSEDYEvlkr 681

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1029 ----KSHEMERAlsrkTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHvplEQVEALKKSlngtI 1104
Cdd:pfam15921  682 nfrnKSEEMETT----TNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR---GQIDALQSK----I 750

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1105 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEK---------EVGIIKASLREKEEESQNKME 1175
Cdd:pfam15921  751 QFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERrlkekvanmEVALDKASLQFAECQDIIQRQ 830

                          810
                   ....*....|..
gi 530406156  1176 EVSKLQSEVQNT 1187
Cdd:pfam15921  831 EQESVRLKLQHT 842
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1017-1390 1.02e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.42  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1017 QKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL 1096
Cdd:COG1196   221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1097 KKSLNGTIENLKEELKSMQRcYEKEQQTVTKLHQLLENQknssvpLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE 1176
Cdd:COG1196   301 EQDIARLEERRRELEERLEE-LEEELAELEEELEELEEE------LEELEEELEEAEEELEEAEAELAEAEEALLEAEAE 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1177 VSKLQSEVQNTKQALKKLETREVVDLSKYKAtksdLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAkdekellhf 1256
Cdd:COG1196   374 LAEAEEELEELAEELLEALRAAAELAAQLEE----LEEAEEALLERLERLEEELEELEEALAELEEEEEEE--------- 440

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1257 siEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTytsgnpTKRQSQLIDTLQ 1336
Cdd:COG1196   441 --EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKA 512

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530406156 1337 HQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL 1390
Cdd:COG1196   513 ALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYL 566
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
286-708 9.71e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 53.53  E-value: 9.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  286 LEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFEsdhlgsgshfsn 365
Cdd:PRK03918  298 LSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYE------------ 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  366 rKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELslpsqtsysENEIlkKELEAMRTFCESAKQDRLKLQNELah 445
Cdd:PRK03918  366 -EAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEI---------EEEI--SKITARIGELKKEIKELKKAIEEL-- 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  446 KVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAA-SGNHRLTEELKDQLKD 524
Cdd:PRK03918  432 KKAKGKCPVCGRELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESElIKLKELAEQLKELEEK 511

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  525 LKV-----------KYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQ---KELSMCEMEREKKGRK-VTEME 589
Cdd:PRK03918  512 LKKynleelekkaeEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDeleEELAELLKELEELGFEsVEELE 591

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  590 GQAKELsaklalsipaEKFENMKSSLSN---EVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVK---PEEH 663
Cdd:PRK03918  592 ERLKEL----------EPFYNEYLELKDaekELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKkysEEEY 661

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 530406156  664 EQVKSRLEQKSGELGKKITELtlknQTLQKEIEKVYLDNKLLKEQ 708
Cdd:PRK03918  662 EELREEYLELSRELAGLRAEL----EELEKRREEIKKTLEKLKEE 702
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 92-220 2.73e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.94  E-value: 2.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   92 LHLAAKYGHALCLQKLLQYNcpteHADLQ-----GRTALHDAAMADCPSSIQLLCDhgasvNAKDV----------DGRT 156
Cdd:cd22192    21 LLLAAKENDVQAIKKLLKCP----SCDLFqrgalGETALHVAALYDNLEAAVVLME-----AAPELvnepmtsdlyQGET 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530406156  157 PLVLATQMSRPTICQLLIDRGADVNSRD------KQNRTALMLGCEY--------GCRDAVEVLIKNGADISLLDALG 220
Cdd:cd22192    92 ALHIAVVNQNLNLVRELIARGADVVSPRatgtffRPGPKNLIYYGEHplsfaacvGNEEIVRLLIEHGADIRAQDSLG 169
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 724-1097 5.02e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 47.70  E-value: 5.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  724 KVSEDMKKSHDAIIDDLNRKLLDVTQKYTeKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQL 803
Cdd:NF033838   73 EIQKSLDKRKHTQNVALNKKLSDIKTEYL-YELNVLKEKSEAELTSKTKKELDAAF---EQFKKDTLEPGKKVAEATKKV 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  804 SELKKKCGEDQEKIHALTSENTnlkkmmsnqyvpVKTHEEVKMTLNDTLAKTNRELLDVKKKF----EDINQEFVKIKDK 879
Cdd:NF033838  149 EEAEKKAKDQKEEDRRNYPTNT------------YKTLELEIAESDVEVKKAELELVKEEAKEprdeEKIKQAKAKVESK 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  880 NEILKRnLENTQNQIKAeyislAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKV 959
Cdd:NF033838  217 KAEATR-LEKIKTDREK-----AEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSV 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  960 --------KYAPIVSFEECERKFKATEKELKDQLSEQTQKY----------SVSEEEVKKNKQENDKLKKEiftlQKDLR 1021
Cdd:NF033838  291 geetlpspSLKPEKKVAEAEKKVEEAKKKAKDQKEEDRRNYptntyktlelEIAESDVKVKEAELELVKEE----AKEPR 366

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1022 DKTVLIEKSHEMERALSRKT------DELNKQLKDLSQKYTEVKNVKEKLVEEnaKQTSEILAVQNLLQKQHVPLEQVEA 1095
Cdd:NF033838  367 NEEKIKQAKAKVESKKAEATrlekikTDRKKAEEEAKRKAAEEDKVKEKPAEQ--PQPAPAPQPEKPAPKPEKPAEQPKA 444


                  ..
gi 530406156 1096 LK 1097
Cdd:NF033838  445 EK 446
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 413-710 3.75e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 41.54  E-value: 3.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  413 SENEILKKELEAMRTFCESAKQDRLklqnELAHKVAECKALALECERVKEDSDEQIKQ--LEDALKDVQKRMYESEGKVK 490
Cdd:NF033838  111 SEAELTSKTKKELDAAFEQFKKDTL----EPGKKVAEATKKVEEAEKKAKDQKEEDRRnyPTNTYKTLELEIAESDVEVK 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  491 QMQTHFLALKEHLTSEaasgnhrlteelKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGklIEENKRLQKE 570
Cdd:NF033838  187 KAELELVKEEAKEPRD------------EEKIKQAKAKVESKKAEATRLEKIKTDREKAEEEAKRRAD--AKLKEAVEKN 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  571 LSMCEMEREKKGRKVTEMEGQA----KELSAKLALSIPAEkfENMKS-SLSNE--VNEKAKKLVEMER------------ 631
Cdd:NF033838  253 VATSEQDKPKRRAKRGVLGEPAtpdkKENDAKSSDSSVGE--ETLPSpSLKPEkkVAEAEKKVEEAKKkakdqkeedrrn 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  632 ---------EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKkiteltlknqtlqkeIEKVYLDN 702
Cdd:NF033838  331 yptntyktlELEIAESDVKVKEAELELVKEEAKEPRNEEKIKQAKAKVESKKAEATR---------------LEKIKTDR 395


                  ....*...
gi 530406156  703 KLLKEQAH 710
Cdd:NF033838  396 KKAEEEAK 403
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 292-650 3.87e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 3.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  292 DLKERLRKIQQEQRILldKVNGLQLQLNEREKLKSLLAAKEKQHEESLRTIEALKNRFKyfesdhlgsgSHFSNRKEDML 371
Cdd:COG1196   217 ELKEELKELEAELLLL--KLRELEAELEELEAELEELEAELEELEAELAELEAELEELR----------LELEELELELE 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  372 LKQGQMYMADSQctspgipahmqsrsmlrplelslpsqtsYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECK 451
Cdd:COG1196   285 EAQAEEYELLAE----------------------------LARLEQDIARLEERRRELEERLEELEEELAELEEELEELE 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  452 ALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSE--AASGNHRLTEELKDQLKDLKVKY 529
Cdd:COG1196   337 EELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAlrAAAELAAQLEELEEAEEALLERL 416

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  530 EGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELsmcEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFE 609
Cdd:COG1196   417 ERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEE---EALLELLAELLEEAALLEAALAELLEELAEAAARL 493

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 530406156  610 NMKSSLSNEVNE-----KAKKLVEMEREHEKSLSEIRQLKRELENV 650
Cdd:COG1196   494 LLLLEAEADYEGflegvKAALLLAGLRGLAGAVAVLIGVEAAYEAA 539
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 17-252 4.00e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.61  E-value: 4.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156    17 DWNKYDDRLMKAAERGDVekvtSILAKKGVNPGKLDVE-----GRSVFHVVTSKGNLECLNAILI-HGVDITTSDTAgrn 90
Cdd:TIGR00870   13 PLSDEEKAFLPAAERGDL----ASVYRDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLLnLSCRGAVGDTL--- 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156    91 aLHLAAKyghalclqkllqyncptEHADLQGRTALHDAAMADCPSSIQLlcdhgasVNAKDVD----GRTPLVLATQMSR 166
Cdd:TIGR00870   86 -LHAISL-----------------EYVDAVEAILLHLLAAFRKSGPLEL-------ANDQYTSeftpGITALHLAAHRQN 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   167 PTICQLLIDRGADVNSR-------DKQNRTALMLGcEY--------GCRDAVEVLIKNGADISLLDALGHdssyyarigd 231
Cdd:TIGR00870  141 YEIVKLLLERGASVPARacgdffvKSQGVDSFYHG-ESplnaaaclGSPSIVALLSEDPADILTADSLGN---------- 209

                          250       260
                   ....*....|....*....|.
gi 530406156   232 nlDILTLLKTASENTNKGREL 252
Cdd:TIGR00870  210 --TLLHLLVMENEFKAEYEEL 228
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-256 2.69e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.48  E-value: 2.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   11 KNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRN 90
Cdd:COG0666    43 ALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGET 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   91 ALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTIC 170
Cdd:COG0666   123 PLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  171 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGR 250
Cdd:COG0666   203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                  ....*.
gi 530406156  251 ELWKKG 256
Cdd:COG0666   283 LDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-248 1.60e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.17  E-value: 1.60e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   11 KNRHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRN 90
Cdd:COG0666    10 LLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   91 ALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTIC 170
Cdd:COG0666    90 LLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530406156  171 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNK 248
Cdd:COG0666   170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA 247
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
40-239 2.58e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 119.29  E-value: 2.58e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   40 ILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADL 119
Cdd:COG0666     6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  120 QGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGC 199
Cdd:COG0666    86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 530406156  200 RDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL 239
Cdd:COG0666   166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-191 6.53e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 94.64  E-value: 6.53e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   13 RHAADWNKYDDR----LMKAAERGDVEKVTsILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAG 88
Cdd:COG0666   108 EAGADVNARDKDgetpLHLAAYNGNLEIVK-LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDG 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   89 RNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPT 168
Cdd:COG0666   187 ETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAAL 266

                         170       180
                  ....*....|....*....|...
gi 530406156  169 ICQLLIDRGADVNSRDKQNRTAL 191
Cdd:COG0666   267 IVKLLLLALLLLAAALLDLLTLL 289
PHA03095 PHA03095
ankyrin-like protein; Provisional
 35-218 1.58e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 93.55  E-value: 1.58e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   35 EKVTSILAKKGVNPGKLDVEGRSVFHV-VTSKG-NLECLNAILIHGVDITTSDTAGRNALHLAAKYGH--ALCLQKLLQY 110
Cdd:PHA03095  132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  111 NCPTEHADLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNR 188
Cdd:PHA03095  212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                         170       180       190
                  ....*....|....*....|....*....|
gi 530406156  189 TALMLGCEYGCRDAVEVLIKNGADISLLDA 218
Cdd:PHA03095  292 TPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 521-1322 1.58e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 95.51  E-value: 1.58e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   521 QLKDLKVKYEGASAEVGKLRNQIKQNEMivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKL- 599
Cdd:TIGR02168  214 RYKELKAELRELELALLVLRLEELREEL--EELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELy 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   600 ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhvKPEEHEQVKSRLEqksgELGK 679
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEE--LKEELESLEAELE----ELEA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   680 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEME 759
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEEL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   760 KLLLEndslsKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVP-- 837
Cdd:TIGR02168  446 EEELE-----ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLsg 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   838 --------VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKD---------------KNEILKRNLENTQNQI 894
Cdd:TIGR02168  521 ilgvlselISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNElgrvtflpldsikgtEIQGNDREILKNIEGF 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   895 KAEYISLAEHEAK----MSSLSQSMRKVQD-SNAEILANYRKGQEEIVTL------------------HAEIKAQKKELD 951
Cdd:TIGR02168  601 LGVAKDLVKFDPKlrkaLSYLLGGVLVVDDlDNALELAKKLRPGYRIVTLdgdlvrpggvitggsaktNSSILERRREIE 680

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   952 TIQECIkvkyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1031
Cdd:TIGR02168  681 ELEEKI----------EELEEKIAELEKALAELRKELEEL----EEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1032 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEEL 1111
Cdd:TIGR02168  747 ERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1112 KSMQRCYEKEQQTVTKLHQLLE-----------NQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1180
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEelsedieslaaEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELREL 906

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1181 QSEVQNTKQALKKLETRevvdLSKYKATKSDLETQISSLNEKLANL-NRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE 1259
Cdd:TIGR02168  907 ESKRSELRRELEELREK----LAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLENKIK 982

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530406156  1260 ----------QEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDV-ERLKQALNGLSQLTYTSG 1322
Cdd:TIGR02168  983 elgpvnlaaiEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARERFKDTfDQVNENFQRVFPKLFGGG 1056
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-239 7.36e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 88.86  E-value: 7.36e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   71 LNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAK 150
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  151 DVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIG 230
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163


                  ....*....
gi 530406156  231 DNLDILTLL 239
Cdd:COG0666   164 GNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
92-184 2.37e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.32  E-value: 2.37e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156    92 LHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDvDGRTPLVLATQMSRPTICQ 171
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 530406156   172 LLIDRGADVNSRD 184
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
59-151 2.60e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 78.23  E-value: 2.60e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156    59 FHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEhaDLQGRTALHDAAMADCPSSIQ 138
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL--KDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 530406156   139 LLCDHGASVNAKD 151
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
125-217 1.53e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 75.92  E-value: 1.53e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   125 LHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRgADVNSRDkQNRTALMLGCEYGCRDAVE 204
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 530406156   205 VLIKNGADISLLD 217
Cdd:pfam12796   79 LLLEKGADINVKD 91
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 748-1390 1.81e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 82.41  E-value: 1.81e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   748 TQKYTEKKLEMEKLLLENDSLSKD--VSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENT 825
Cdd:TIGR02168  212 AERYKELKAELRELELALLVLRLEelREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELY 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   826 NLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHE 905
Cdd:TIGR02168  292 ALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELE 371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   906 AKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVS--FEECERKFKATEKELKD 983
Cdd:TIGR02168  372 SRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEaeLKELQAELEELEEELEE 451

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   984 QLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE 1063
Cdd:TIGR02168  452 LQEELERL----EEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSE 527

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1064 KL-VEENAKQTSEIL---AVQNLL-QKQHVPLEQVEALKKSLNG-------------TIENLKEELKSMQRCYEKEQ--- 1122
Cdd:TIGR02168  528 LIsVDEGYEAAIEAAlggRLQAVVvENLNAAKKAIAFLKQNELGrvtflpldsikgtEIQGNDREILKNIEGFLGVAkdl 607

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1123 -QTVTKLHQLLENQKNSSVP---LAEHLQIKEAFEKEVGII--------------------KASLREKEEESQNKMEEVS 1178
Cdd:TIGR02168  608 vKFDPKLRKALSYLLGGVLVvddLDNALELAKKLRPGYRIVtldgdlvrpggvitggsaktNSSILERRREIEELEEKIE 687

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1179 KLQSEVQNTKQALKKLETREV---VDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLH 1255
Cdd:TIGR02168  688 ELEEKIAELEKALAELRKELEeleEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELE 767

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1256 FSI-----------------EQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLt 1318
Cdd:TIGR02168  768 ERLeeaeeelaeaeaeieelEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ- 846

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530406156  1319 ytsgnpTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRT-----HLLSAAQGHMDEDVQEALLQIIQMRQGL 1390
Cdd:TIGR02168  847 ------IEELSEDIESLAAEIEELEELIEELESELEALLNERASleealALLRSELEELSEELRELESKRSELRREL 917
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 665-1303 4.99e-15

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 80.45  E-value: 4.99e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   665 QVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKL 744
Cdd:TIGR04523  117 EQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKL 196

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   745 LDVTQKYTEKKLEMEKllleNDSLSKDVSRLEtvfvppekheKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSEN 824
Cdd:TIGR04523  197 LKLELLLSNLKKKIQK----NKSLESQISELK----------KQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQ 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   825 TNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKfedinqefvKIKDKNEILKRNLENTQNQIKAEYISLAEH 904
Cdd:TIGR04523  263 NKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQ---------KEQDWNKELKSELKNQEKKLEEIQNQISQN 333

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   905 EAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQ 984
Cdd:TIGR04523  334 NKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ 413

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   985 LSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKshemeraLSRKTDELNKQLKDLSQKYTEVKNVKEK 1064
Cdd:TIGR04523  414 IKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKN-------LDNTRESLETQLKVLSRSINKIKQNLEQ 486

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1065 LVEENAKQTSEILAVQNLlqkqhvpleqvealKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKnssvplae 1144
Cdd:TIGR04523  487 KQKELKSKEKELKKLNEE--------------KKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLE-------- 544

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1145 hlqiKEAFEKEVGIIKASLrekEEESQNKMEEVSKLQSEVQNTKQALKKLETrevvDLSKYKATKSDLETQISSLNEKLA 1224
Cdd:TIGR04523  545 ----DELNKDDFELKKENL---EKEIDEKNKEIEELKQTQKSLKKKQEEKQE----LIDQKEKEKKDLIKEIEEKEKKIS 613

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530406156  1225 NLNRKYEEVCEEvlhaKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIeakdNKITELLND 1303
Cdd:TIGR04523  614 SLEKELEKAKKE----NEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKI----DDIIELMKD 684
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
606-1195 2.12e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 78.57  E-value: 2.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  606 EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAqhvKPEEHEQVKSRLEQKSGELGKKITELT 685
Cdd:PRK03918  182 EKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVK---ELEELKEEIEELEKELESLEGSKRKLE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  686 LKNQTLQKEIEKVYLDNKLLKEQAhnltiemknhyvplKVSEDMKKSHDAIIddlnrKLLDVTQKYTEKKLEMEKLLlen 765
Cdd:PRK03918  259 EKIRELEERIEELKKEIEELEEKV--------------KELKELKEKAEEYI-----KLSEFYEEYLDELREIEKRL--- 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  766 DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCgEDQEKIHALTSENTNLKKMMSNQyvpvktheevk 845
Cdd:PRK03918  317 SRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERH-ELYEEAKAKKEELERLKKRLTGL----------- 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  846 mtlndTLAKTNRELLDVKKKFEDINQEFVKIKDKneilKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMrkVQDSNAEI 925
Cdd:PRK03918  385 -----TPEKLEKELEELEKAKEEIEEEISKITAR----IGELKKEIKELKKAIEELKKAKGKCPVCGREL--TEEHRKEL 453

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  926 LANYRKGQEEIVTLHAEIKAQKKELdtiqECIKVKYAPIVSFEECERKFKATEKELKDqLSEQTQKYSVSE-----EEVK 1000
Cdd:PRK03918  454 LEEYTAELKRIEKELKEIEEKERKL----RKELRELEKVLKKESELIKLKELAEQLKE-LEEKLKKYNLEElekkaEEYE 528

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1001 KNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQK-YTEVKNVKEKLVE---------ENA 1070
Cdd:PRK03918  529 KLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgFESVEELEERLKElepfyneylELK 608

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1071 KQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQqtvtklHQLLENQKNSsvplaehlqike 1150
Cdd:PRK03918  609 DAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEE------YEELREEYLE------------ 670

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 530406156 1151 aFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLE 1195
Cdd:PRK03918  671 -LSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELE 714
PTZ00121 PTZ00121
MAEBL; Provisional
 442-1249 3.40e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 78.26  E-value: 3.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  442 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKehltseaASGNHRLTEELKDQ 521
Cdd:PTZ00121 1167 EEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKK-------AEAVKKAEEAKKDA 1239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  522 LKDLKVKYEGASAEVGKLRN-QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA 600
Cdd:PTZ00121 1240 EEAKKAEEERNNEEIRKFEEaRMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADE 1319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  601 LSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKK 680
Cdd:PTZ00121 1320 AKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKK 1399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  681 ITELTLKNQTLQKEIEKvyldnKLLKEQAHNLTIEMKnhyvplKVSEDMKKSHDAIIDDLNRKLLDVTQKYTE--KKLEM 758
Cdd:PTZ00121 1400 AEEDKKKADELKKAAAA-----KKKADEAKKKAEEKK------KADEAKKKAEEAKKADEAKKKAEEAKKAEEakKKAEE 1468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  759 EKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNiVELKKQLSELKKkcGEDQEKIHALTSENTNLKKMMSNQYVPV 838
Cdd:PTZ00121 1469 AKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA-AEAKKKADEAKK--AEEAKKADEAKKAEEAKKADEAKKAEEK 1545

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  839 KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKV 918
Cdd:PTZ00121 1546 KKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEEL 1625

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  919 QDSNAEilanyRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKfkaTEKELKDQLSEQTQKysvsEEE 998
Cdd:PTZ00121 1626 KKAEEE-----KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKK---KAEEAKKAEEDEKKA----AEA 1693

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  999 VKKNKQEndklKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKnvkeklVEENAKQTSEILA 1078
Cdd:PTZ00121 1694 LKKEAEE----AKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAK------KDEEEKKKIAHLK 1763

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1079 VQNLLQKQHVPLEQVEALKKSLNgtienlKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGI 1158
Cdd:PTZ00121 1764 KEEEKKAEEIRKEKEAVIEEELD------EEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVAD 1837

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1159 IKASLREKEEESQNKMEEVSKLQSEVQNTKQALKK--------LETREVVDLSKyKATKSDLETQISSLNEKLAN----- 1225
Cdd:PTZ00121 1838 SKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKekdlkeddEEEIEEADEIE-KIDKDDIEREIPNNNMAGKNndiid 1916

                         810       820       830
                  ....*....|....*....|....*....|..
gi 530406156 1226 --------LNRKYEEVCEEVLHAKKKEISAKD 1249
Cdd:PTZ00121 1917 dkldkdeyIKRDAEETREEIIKISKKDMCIND 1948
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 62-213 1.04e-13

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 76.06  E-value: 1.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   62 VTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLC 141
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530406156  142 dHGASVNAKDVDGRTpLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADI 213
Cdd:PLN03192  612 -HFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
516-1116 1.18e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.26  E-value: 1.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  516 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEF---KRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQA 592
Cdd:PRK03918  203 EEVLREINEISSELPELREELEKLEKEVKELEELKEEIeelEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKV 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  593 KELsaklalsipaekfenmksslsNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLaqhvkpEEHEQVKSRLEQ 672
Cdd:PRK03918  283 KEL---------------------KELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEI------NGIEERIKELEE 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  673 KSGELGkkitELTLKNQTLQKEIEKVYLDNKLLkEQAHNLTIEMKNHyvplkvsedMKKSHDAIIDDLNRKLLDVTQKYT 752
Cdd:PRK03918  336 KEERLE----ELKKKLKELEKRLEELEERHELY-EEAKAKKEELERL---------KKRLTGLTPEKLEKELEELEKAKE 401

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  753 EKKLEMEKLllendslskdvsrletvfvppekhEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTnlKKMMS 832
Cdd:PRK03918  402 EIEEEISKI------------------------TARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHR--KELLE 455

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  833 NQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDiNQEFVKIKDKNEILKrNLENTQNQIKAEYISLAEHEakmssls 912
Cdd:PRK03918  456 EYTAELKRIEKELKEIEEKERKLRKELRELEKVLKK-ESELIKLKELAEQLK-ELEEKLKKYNLEELEKKAEE------- 526

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  913 qsmrkvqdsnaeilanYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKyapivsfEECERKFKATEKELKDQLSEQTQKY 992
Cdd:PRK03918  527 ----------------YEKLKEKLIKLKGEIKSLKKELEKLEELKKKL-------AELEKKLDELEEELAELLKELEELG 583

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  993 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL-VEENAK 1071
Cdd:PRK03918  584 FESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYsEEEYEE 663

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 530406156 1072 QTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQR 1116
Cdd:PRK03918  664 LREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREK 708
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
862-1356 2.81e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 74.72  E-value: 2.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  862 VKKKFEDINQEFVKIKDKNEILKRNLENtqnqIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHA 941
Cdd:PRK03918  198 KEKELEEVLREINEISSELPELREELEK----LEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKK 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  942 EIKAQKKELDTIQEcIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKkEIFTLQKDLR 1021
Cdd:PRK03918  274 EIEELEEKVKELKE-LKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLE-ELKKKLKELE 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1022 DKTVLIEKSHE--------MERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQV 1093
Cdd:PRK03918  352 KRLEELEERHElyeeakakKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEEL 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1094 EA-------------------LKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEK 1154
Cdd:PRK03918  432 KKakgkcpvcgrelteehrkeLLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEK 511

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1155 EVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLEtrevvdlsKYKATKSDLETQISSLNEKLANLNRKYEEV- 1233
Cdd:PRK03918  512 LKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLE--------ELKKKLAELEKKLDELEEELAELLKELEELg 583

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1234 --CEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELL-----NDVER 1306
Cdd:PRK03918  584 feSVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEkkyseEEYEE 663

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 530406156 1307 LKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEV 1356
Cdd:PRK03918  664 LREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKEL 713
PHA03095 PHA03095
ankyrin-like protein; Provisional
 32-232 3.41e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.52  E-value: 3.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   32 GDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILI-HGVDITTSDTAGRNALH--LAAKYGHALCLQKLL 108
Cdd:PHA03095   60 EKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTLDVIKLLIkAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLL 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  109 QYNCPTEHADLQGRTALH------DAamadCPSSIQLLCDHGASVNAKDVDGRTPL--VLATQMSRPTICQLLIDRGADV 180
Cdd:PHA03095  140 RKGADVNALDLYGMTPLAvllksrNA----NVELLRLLIDAGADVYAVDDRFRSLLhhHLQSFKPRARIVRELIRAGCDP 215

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530406156  181 NSRDKQNRTALMLGCEYG-CRDA-VEVLIKNGADISLLDALGHDSSYYARIGDN 232
Cdd:PHA03095  216 AATDMLGNTPLHSMATGSsCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNN 269
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 458-1233 3.97e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 74.72  E-value: 3.97e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   458 ERVKEDSDEQIKQL-------EDALK--DVQKRMYESEGKVkqmqtHFLALKEHLTSEAASGNHRltEELKDQLKDLKVK 528
Cdd:TIGR02169  187 ERLDLIIDEKRQQLerlrrerEKAERyqALLKEKREYEGYE-----LLKEKEALERQKEAIERQL--ASLEEELEKLTEE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   529 YEGASAEVGKLRNQIKqnemivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLA-LSIPAEK 607
Cdd:TIGR02169  260 ISELEKRLEEIEQLLE------ELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAkLEAEIDK 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   608 FENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVkpEEHEQVKSRLEQKSGELGKKITELTLK 687
Cdd:TIGR02169  334 LLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETR--DELKDYREKLEKLKREINELKRELDRL 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   688 NQTLQK-EIEKVYLDNKL--LKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLE 764
Cdd:TIGR02169  412 QEELQRlSEELADLNAAIagIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRE 491

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   765 NDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKC--------------------GEDQEKIHALTSEN 824
Cdd:TIGR02169  492 LAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYataievaagnrlnnvvveddAVAKEAIELLKRRK 571

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   825 TN------LKKMMSNQYVPVKTHEE-------------------VKMTLNDTLA----KTNRELLD-------------- 861
Cdd:TIGR02169  572 AGratflpLNKMRDERRDLSILSEDgvigfavdlvefdpkyepaFKYVFGDTLVvediEAARRLMGkyrmvtlegelfek 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   862 --------VKKKFEDINQefVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQ 933
Cdd:TIGR02169  652 sgamtggsRAPRGGILFS--RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLE 729

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   934 EEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYsvSEEEVKKNKQENDKLKKEI 1013
Cdd:TIGR02169  730 QEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARL--SHSRIPEIQAELSKLEEEV 807

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1014 FTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLsqkyTEVKNVKEKLVEENAKQTSEILAVqnlLQKQHVPLEQV 1093
Cdd:TIGR02169  808 SRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDL----KEQIKSIEKEIENLNGKKEELEEE---LEELEAALRDL 880

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1094 EALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsvplaehlqiKEAFEKEVGIIKASLREKEEESQNK 1173
Cdd:TIGR02169  881 ESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAK----------LEALEEELSEIEDPKGEDEEIPEEE 950

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1174 MEEvSKLQSEVQNTKQALKKLET----------REVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEV 1233
Cdd:TIGR02169  951 LSL-EDVQAELQRVEEEIRALEPvnmlaiqeyeEVLKRLDELKEKRAKLEEERKAILERIEEYEKKKREV 1019
PTZ00121 PTZ00121
MAEBL; Provisional
 608-1306 6.23e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 74.02  E-value: 6.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  608 FENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLK 687
Cdd:PTZ00121 1081 FDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKA 1160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  688 NQTLQKEIEKVYLDNKllKEQAHNLTIEMKNHYvPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDS 767
Cdd:PTZ00121 1161 EDARKAEEARKAEDAK--KAEAARKAEEVRKAE-ELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKK 1237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  768 LSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNlkkmmsnqyvpvKTHEEVKMT 847
Cdd:PTZ00121 1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAK------------KAEEKKKAD 1305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  848 LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAeyislAEHEAKMSSLSQSMRKVQDSNAEILA 927
Cdd:PTZ00121 1306 EAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEA-----AADEAEAAEEKAEAAEKKKEEAKKKA 1380

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  928 NYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEK--ELKDQLSEQTQKYSVSEEEVKKNKQE 1005
Cdd:PTZ00121 1381 DAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKadEAKKKAEEAKKADEAKKKAEEAKKAE 1460

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1006 NDKLKKEIFTLQKDLRDKTVLIEKSHEMERA---LSRKTDELNKQlKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNL 1082
Cdd:PTZ00121 1461 EAKKKAEEAKKADEAKKKAEEAKKADEAKKKaeeAKKKADEAKKA-AEAKKKADEAKKAEEAKKADEAKKAEEAKKADEA 1539

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1083 LQKQHV----PLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGI 1158
Cdd:PTZ00121 1540 KKAEEKkkadELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAK 1619

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1159 IKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVL 1238
Cdd:PTZ00121 1620 IKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAE 1699

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1239 HAKKKEISAKDEKELLHfSIEQEIKDQKERCDKS--LTTITELQRRIQESAKQIEAKDNKITELLNDVER 1306
Cdd:PTZ00121 1700 EAKKAEELKKKEAEEKK-KAEELKKAEEENKIKAeeAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEK 1768
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 403-1113 7.79e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 73.55  E-value: 7.79e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   403 ELSLPSQTSYSENEILKKELEAMrtfcESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRM 482
Cdd:TIGR02168  257 ELTAELQELEEKLEELRLEVSEL----EEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKL 332

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   483 YESEGKVKQMQTHFLALKEHLTSEAASGN--HRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKL 560
Cdd:TIGR02168  333 DELAEELAELEEKLEELKEELESLEAELEelEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERL 412

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   561 IEENKRLQKELSMCEMEREKKGRKVTEME-GQAKELSAKLALSIpaEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSE 639
Cdd:TIGR02168  413 EDRRERLQQEIEELLKKLEEAELKELQAElEELEEELEELQEEL--ERLEEALEELREELEEAEQALDAAERELAQLQAR 490

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   640 IRQLKRELENVK--------AKLAQHVKPEEHEQVKSRLEQKSG-------ELGKKITELTLKNQTLQKEIekVYLDNKL 704
Cdd:TIGR02168  491 LDSLERLQENLEgfsegvkaLLKNQSGLSGILGVLSELISVDEGyeaaieaALGGRLQAVVVENLNAAKKA--IAFLKQN 568

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   705 LKEQAHNLTIEMKNHYVPLKVSEDMKKSHD---------------------------AIIDDLN-----RKLLD-----V 747
Cdd:TIGR02168  569 ELGRVTFLPLDSIKGTEIQGNDREILKNIEgflgvakdlvkfdpklrkalsyllggvLVVDDLDnalelAKKLRpgyriV 648

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   748 T--------------------QKYTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQLSELK 807
Cdd:TIGR02168  649 TldgdlvrpggvitggsaktnSSILERRREIEELEEKIEELEEKIAELEKAL---AELRKELEELEEELEQLRKELEELS 725

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   808 KKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNL 887
Cdd:TIGR02168  726 RQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL 805

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   888 ENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKY------ 961
Cdd:TIGR02168  806 DELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLnerasl 885

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   962 -APIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDK-TVLIEKSHEMERALSR 1039
Cdd:TIGR02168  886 eEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEySLTLEEAEALENKIED 965

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530406156  1040 KTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEilavQNLLQKQHvplEQVEALKKSLNGTIENLKEELKS 1113
Cdd:TIGR02168  966 DEEEARRRLKRLENKIKELGPVNLAAIEEYEELKER----YDFLTAQK---EDLTEAKETLEEAIEEIDREARE 1032
PTZ00121 PTZ00121
MAEBL; Provisional
 496-1293 9.26e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 73.64  E-value: 9.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  496 FLALKEHLTSEAASGNHRLTEELKdQLKDLKVKYEGASAEVGKLRNQIKQNEmivEEFKRDEGKLIEENKRLQKELSMCE 575
Cdd:PTZ00121 1081 FDAKEDNRADEATEEAFGKAEEAK-KTETGKAEEARKAEEAKKKAEDARKAE---EARKAEDARKAEEARKAEDAKRVEI 1156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  576 MEREKKGRKVTEMEGQAKELSAKlalsiPAEKFENMKSSLSNEVNEKAKKLVEMER-EHEKSLSEIRQLKRELENVKAKL 654
Cdd:PTZ00121 1157 ARKAEDARKAEEARKAEDAKKAE-----AARKAEEVRKAEELRKAEDARKAEAARKaEEERKAEEARKAEDAKKAEAVKK 1231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  655 AQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEI--EKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKS 732
Cdd:PTZ00121 1232 AEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIkaEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKA 1311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  733 HDAiiddlnRKLLDVTQKYTEKKLEMEKLLLENDSLSKdvsRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGE 812
Cdd:PTZ00121 1312 EEA------KKADEAKKKAEEAKKKADAAKKKAEEAKK---AAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADA 1382

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  813 DQEKIHALTSENTNLKKMMSNQyvpvKTHEEVKMTlndtlAKTNRELLDVKKKFEDinqefvkiKDKNEILKRNLENTQn 892
Cdd:PTZ00121 1383 AKKKAEEKKKADEAKKKAEEDK----KKADELKKA-----AAAKKKADEAKKKAEE--------KKKADEAKKKAEEAK- 1444

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  893 qiKAEYISLAEHEAKMSSlsqsmrkvqdsNAEILANYRKGQEEIVTlHAEIKAQKKELDTIQECIKVKYApivsfeecER 972
Cdd:PTZ00121 1445 --KADEAKKKAEEAKKAE-----------EAKKKAEEAKKADEAKK-KAEEAKKADEAKKKAEEAKKKAD--------EA 1502

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  973 KFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKdlS 1052
Cdd:PTZ00121 1503 KKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMA--L 1580

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1053 QKYTEVKNVKEKLVEENAKQTSEILAVQ-NLLQKQHVPLEQVEALKKSlngtienlKEELKSMQRCYEKEQQTVTKLHQL 1131
Cdd:PTZ00121 1581 RKAEEAKKAEEARIEEVMKLYEEEKKMKaEEAKKAEEAKIKAEELKKA--------EEEKKKVEQLKKKEAEEKKKAEEL 1652

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1132 LENQKNSSVPlAEHLQIKEAFEKEvgiiKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSD 1211
Cdd:PTZ00121 1653 KKAEEENKIK-AAEEAKKAEEDKK----KAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEE 1727

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1212 LETQISSLNEKLANLNRKYEEvceevlhAKKKEisaKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIE 1291
Cdd:PTZ00121 1728 NKIKAEEAKKEAEEDKKKAEE-------AKKDE---EEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVD 1797


                  ..
gi 530406156 1292 AK 1293
Cdd:PTZ00121 1798 KK 1799
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 527-1305 1.07e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 73.18  E-value: 1.07e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   527 VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG----RKVTEMEGQAKELSAKLA-L 601
Cdd:TIGR02169  170 RKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGyellKEKEALERQKEAIERQLAsL 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   602 SIPAEKFENMKSSLSNEVNEKAKKLVEMERE-HEKSLSEIRQLKRELENVKAKLAQHV-KPEEHEQVKSRLEQKSGELGK 679
Cdd:TIGR02169  250 EEELEKLTEEISELEKRLEEIEQLLEELNKKiKDLGEEEQLRVKEKIGELEAEIASLErSIAEKERELEDAEERLAKLEA 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   680 KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLK-VSEDMKKSHDAIiDDLNRKLLDVTQKYTEKKLEM 758
Cdd:TIGR02169  330 EIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEeVDKEFAETRDEL-KDYREKLEKLKREINELKREL 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   759 EKLLLENDSLSKDVSRletvfvppekHEKEIIALKSNIVELKKQLSELkkkcgedQEKIHALTSENTNLKKMMSNQYVPV 838
Cdd:TIGR02169  409 DRLQEELQRLSEELAD----------LNAAIAGIEAKINELEEEKEDK-------ALEIKKQEWKLEQLAADLSKYEQEL 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   839 KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIkAEYISLAEHEAKMSSLSQSMR-- 916
Cdd:TIGR02169  472 YDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTV-AQLGSVGERYATAIEVAAGNRln 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   917 -------KVQDSNAEILANYRKGQEEIVTLHaEIKAQKKELDTIQECIKVKYApiVSFEECERKFkatekelkdqlsEQT 989
Cdd:TIGR02169  551 nvvveddAVAKEAIELLKRRKAGRATFLPLN-KMRDERRDLSILSEDGVIGFA--VDLVEFDPKY------------EPA 615

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   990 QKYSVSEEEVKKNKQENDKL--KKEIFTLQKDLRDKTVLIEKSH--------------EMERALSRKTDELNKQLKDLSQ 1053
Cdd:TIGR02169  616 FKYVFGDTLVVEDIEAARRLmgKYRMVTLEGELFEKSGAMTGGSraprggilfsrsepAELQRLRERLEGLKRELSSLQS 695

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1054 KYTEVKN-VKEKL--VEENAKQTSEILAVQNLLQKQHVP----LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT 1126
Cdd:TIGR02169  696 ELRRIENrLDELSqeLSDASRKIGEIEKEIEQLEQEEEKlkerLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLH 775

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1127 KLHQLLEN--QKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvvdlSK 1204
Cdd:TIGR02169  776 KLEEALNDleARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQI----KS 851

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1205 YKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKEllhfSIEQEIKDQKERCDKSLTTITELQRRIQ 1284
Cdd:TIGR02169  852 IEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLR----ELERKIEELEAQIEKKRKRLSELKAKLE 927

                          810       820
                   ....*....|....*....|.
gi 530406156  1285 ESAKQIEAKDNKITELLNDVE 1305
Cdd:TIGR02169  928 ALEEELSEIEDPKGEDEEIPE 948
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 35-222 2.22e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 70.76  E-value: 2.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   35 EKVTSILaKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPT 114
Cdd:PHA02874  105 DMIKTIL-DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  115 EHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTIcQLLIDrGADVNSRDKQNRTALMLG 194
Cdd:PHA02874  184 NVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI-ELLIN-NASINDQDIDGSTPLHHA 261

                         170       180
                  ....*....|....*....|....*....
gi 530406156  195 CEYGC-RDAVEVLIKNGADISLLDALGHD 222
Cdd:PHA02874  262 INPPCdIDIIDILLYHKADISIKDNKGEN 290
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
436-958 3.04e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 71.63  E-value: 3.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  436 RLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEaasgnhRLT 515
Cdd:PRK03918  229 EVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLS------EFY 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  516 EELKDQLKDLKVKYEGASAEVGKLRNQIKQnemiVEEFKRDEGKLIEENKRLQKELSMCEmEREKKGRKVTEMEGQAKEL 595
Cdd:PRK03918  303 EEYLDELREIEKRLSRLEEEINGIEERIKE----LEEKEERLEELKKKLKELEKRLEELE-ERHELYEEAKAKKEELERL 377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  596 SAKLAlSIPAEKFENMKSSLSN---EVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAK---LAQHVKPEEHEQVKSR 669
Cdd:PRK03918  378 KKRLT-GLTPEKLEKELEELEKakeEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvCGRELTEEHRKELLEE 456

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  670 LEQKSGELGKKITELTLKNQTLQKEIEKVylDNKLLKEQAhnlTIEMKNHYVPLKVSEDMKKSHDAiiddlnrklldvtQ 749
Cdd:PRK03918  457 YTAELKRIEKELKEIEEKERKLRKELREL--EKVLKKESE---LIKLKELAEQLKELEEKLKKYNL-------------E 518

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  750 KYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQ-EKIHALTSENTNLK 828
Cdd:PRK03918  519 ELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGfESVEELEERLKELE 598

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  829 KMMsNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNL-ENTQNQIKAEYISLAEHEAK 907
Cdd:PRK03918  599 PFY-NEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYsEEEYEELREEYLELSRELAG 677

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 530406156  908 MSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIK 958
Cdd:PRK03918  678 LRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLEKALERVEELRE 728
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 466-1262 1.45e-11

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 69.70  E-value: 1.45e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   466 EQIKQLEDALKDVQKRMYESegKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 545
Cdd:TIGR01612  974 DKINELDKAFKDASLNDYEA--KNNELIKYFNDLKANLGKNKENMLYHQFDEKEKATNDIEQKIEDANKNIPNIEIAIHT 1051

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   546 NEM-IVEEFKRDEGKLIEE-NKRLQKE--LSMCEMEREKKGRKVTEMEGQAKELSAKLALSIpaEKFENMKSSLSNEVNE 621
Cdd:TIGR01612 1052 SIYnIIDEIEKEIGKNIELlNKEILEEaeINITNFNEIKEKLKHYNFDDFGKEENIKYADEI--NKIKDDIKNLDQKIDH 1129

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   622 KAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQ----VKSRLEQKSG---ELGKKITELTL--KNQTLQ 692
Cdd:TIGR01612 1130 HIKALEEIKKKSENYIDEIKAQINDLEDVADKAISNDDPEEIEKkienIVTKIDKKKNiydEIKKLLNEIAEieKDKTSL 1209

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   693 KEIEKVYLD-----NKLLKEQAHnltiEMKnhyvplKVSEDMKKSHDAIIDDLNrkllDVTQKYTEKKLEMEKLLLENds 767
Cdd:TIGR01612 1210 EEVKGINLSygknlGKLFLEKID----EEK------KKSEHMIKAMEAYIEDLD----EIKEKSPEIENEMGIEMDIK-- 1273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   768 lskdvSRLETVFVPPEKHEKEIIALKSNivelKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMT 847
Cdd:TIGR01612 1274 -----AEMETFNISHDDDKDHHIISKKH----DENISDIREKSLKIIEDFSEESDINDIKKELQKNLLDAQKHNSDINLY 1344

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   848 LNDTLAKTN-RELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA--EYISLAEHEAKMSSLSQSmrkvQDSNaE 924
Cdd:TIGR01612 1345 LNEIANIYNiLKLNKIKKIIDEVKEYTKEIEENNKNIKDELDKSEKLIKKikDDINLEECKSKIESTLDD----KDID-E 1419

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   925 ILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIvsfEECERKFKATEKELKD-----------QLSEQTQKYS 993
Cdd:TIGR01612 1420 CIKKIKELKNHILSEESNIDTYFKNADENNENVLLLFKNI---EMADNKSQHILKIKKDnatndhdfninELKEHIDKSK 1496

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   994 VSEEEVKKNKQENDKlKKEIFTLQKdlRDKTVLIEKSHEMEralsrKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1073
Cdd:TIGR01612 1497 GCKDEADKNAKAIEK-NKELFEQYK--KDVTELLNKYSALA-----IKNKFAKTKKDSEIIIKEIKDAHKKFILEAEKSE 1568

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1074 SEIlavqNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQrcyekeqqtvTKLHQLLENQKNSSVPLAEhlqiKEAFE 1153
Cdd:TIGR01612 1569 QKI----KEIKKEKFRIEDDAAKNDKSNKAAIDIQLSLENFE----------NKFLKISDIKKKINDCLKE----TESIE 1630

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1154 KEVGIIkaSLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETRevvdlskyKATKSDLETQISSLNEKLANLNRKYE-- 1231
Cdd:TIGR01612 1631 KKISSF--SIDSQDTELKENGDNLNSLQEFLESLKDQKKNIEDK--------KKELDELDSEIEKIEIDVDQHKKNYEig 1700

                          810       820       830
                   ....*....|....*....|....*....|...
gi 530406156  1232 --EVCEEVLHAKKKEISAKdeKELLHFSIEQEI 1262
Cdd:TIGR01612 1701 iiEKIKEIAIANKEEIESI--KELIEPTIENLI 1731
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 630-1309 1.47e-11

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 69.28  E-value: 1.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   630 EREHEKSLSEIRQLKRELENVKAKLAQHVKPE-EHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQ 708
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLDKNLnKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   709 AHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLldvtqkyTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKE 788
Cdd:TIGR04523  112 IKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEI-------KKKEKELEKLNNKYNDLKKQKEELENEL---NLLEKE 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   789 IIALKSNIVELKKQLSELKKKCGEDQEKIH---ALTSENTNLKKMMSNqyvpvktheevkmtLNDTLAKTNRELLDVKKK 865
Cdd:TIGR04523  182 KLNIQKNIDKIKNKLLKLELLLSNLKKKIQknkSLESQISELKKQNNQ--------------LKDNIEKKQQEINEKTTE 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   866 FEDINQEFVKIKDKNEILKRNLENTQNQIKaeyislaEHEAKMSSLSQsmrKVQDSNAEILA-NYRKGQEEIVTLHAEIK 944
Cdd:TIGR04523  248 ISNTQTQLNQLKDEQNKIKKQLSEKQKELE-------QNNKKIKELEK---QLNQLKSEISDlNNQKEQDWNKELKSELK 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   945 AQKKELDTIQECIKVKYAPIVSFEECERKFKATEK-------ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQ 1017
Cdd:TIGR04523  318 NQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTnsesensEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLE 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1018 KDLRDKTVLiekshemeralsrkTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEIlavQNLLQKQHVpleqVEALK 1097
Cdd:TIGR04523  398 SKIQNQEKL--------------NQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEI---KDLTNQDSV----KELII 456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1098 KSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNkmeEV 1177
Cdd:TIGR04523  457 KNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLES---EK 533

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1178 SKLQSEVQNTKQALKKLETRevvdlskykATKSDLETQISSLNEKLanlnrkyeevcEEVLHAKKKEISAKDEKELLHFS 1257
Cdd:TIGR04523  534 KEKESKISDLEDELNKDDFE---------LKKENLEKEIDEKNKEI-----------EELKQTQKSLKKKQEEKQELIDQ 593

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530406156  1258 IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQ 1309
Cdd:TIGR04523  594 KEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQ 645
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 283-1116 3.89e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 68.16  E-value: 3.89e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   283 IQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNErekLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLgsgsH 362
Cdd:TIGR02168  234 LEELREELEELQEELKEAEEELEELTAELQELEEKLEE---LRLEVSELEEEIEELQKELYALANEISRLEQQKQ----I 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   363 FSNRKEDMLLKQgqmymadsqctspgipahmqsrsmlrpLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNE 442
Cdd:TIGR02168  307 LRERLANLERQL---------------------------EELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAE 359

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   443 LAHKVAECKALalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTseaasgnhRLTEELKDQL 522
Cdd:TIGR02168  360 LEELEAELEEL----ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRE--------RLQQEIEELL 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   523 KDLKvkyegasaevgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALs 602
Cdd:TIGR02168  428 KKLE-------------EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDS- 493

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   603 ipAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIR---QLKRELENVKAKLAQHVKPEEHEQVKSRLE-QKSGELG 678
Cdd:TIGR02168  494 --LERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvdeGYEAAIEAALGGRLQAVVVENLNAAKKAIAfLKQNELG 571

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   679 KkiteLTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKK--SHDAIIDDLnrklldvtqkytEKKL 756
Cdd:TIGR02168  572 R----VTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYllGGVLVVDDL------------DNAL 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   757 EMEKLLLENDSL-SKDVSRLETVFVPPEKHEKEiialKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQy 835
Cdd:TIGR02168  636 ELAKKLRPGYRIvTLDGDLVRPGGVITGGSAKT----NSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEEL- 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   836 vpvkthEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA-------EYISLAEHEAKM 908
Cdd:TIGR02168  711 ------EEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEEleerleeAEEELAEAEAEI 784

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   909 SSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQ 988
Cdd:TIGR02168  785 EELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEEL 864

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   989 TQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVK----NVKEK 1064
Cdd:TIGR02168  865 EELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEvridNLQER 944

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530406156  1065 LVEEnakqtseilavqnllqkQHVPLEQVEALKKSLNGTIENLKEELKSMQR 1116
Cdd:TIGR02168  945 LSEE-----------------YSLTLEEAEALENKIEDDEEEARRRLKRLEN 979
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-181 3.90e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 67.00  E-value: 3.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   33 DVEKVTSILAKKGVNPGKLDVEGRSVFHV--VTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHA------LCL 104
Cdd:PHA03100   84 DVKEIVKLLLEYGANVNAPDNNGITPLLYaiSKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlkilkLLI 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  105 QK------------LLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQL 172
Cdd:PHA03100  164 DKgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKL 243


                  ....*....
gi 530406156  173 LIDRGADVN 181
Cdd:PHA03100  244 LLNNGPSIK 252
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 24-257 5.08e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 67.40  E-value: 5.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   24 RLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALC 103
Cdd:PHA02876  147 KLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDT 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  104 LQKLLQYNCPTEHADLQGRTALHDaamADCPSSIqLLCDHGASVNAKDVDGRTPLVLATQMsrPTICQL---LIDRGADV 180
Cdd:PHA02876  227 IKAIIDNRSNINKNDLSLLKAIRN---EDLETSL-LLYDAGFSVNSIDDCKNTPLHHASQA--PSLSRLvpkLLERGADV 300

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530406156  181 NSRDKQNRTALMLGCEYGC-RDAVEVLIKNGADISLLDALGHDSSYYARIGD-NLDILTLLKTASENTNkGRELWKKGP 257
Cdd:PHA02876  301 NAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVN-ARDYCDKTP 378
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 418-1187 7.04e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 67.07  E-value: 7.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   418 LKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLedalkdvQKRMYESEGKVKQMQTHFL 497
Cdd:pfam15921  122 MQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQL-------RKMMLSHEGVLQEIRSILV 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   498 ALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIE-----ENKRLQKELS 572
Cdd:pfam15921  195 DFEEASGKKIYEHDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIElllqqHQDRIEQLIS 274

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   573 MCEMEREKKGRKVTEMEGQAKELSAKLalsipaekfENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA 652
Cdd:pfam15921  275 EHEVEITGLTEKASSARSQANSIQSQL---------EIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIE 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   653 KLAQHVKPEEHEQVKSRLE-----QKSGELGKKITELTLKNQTLQKEIEkvyldnkLLKEQAHNLTiemknhyvplkvse 727
Cdd:pfam15921  346 ELEKQLVLANSELTEARTErdqfsQESGNLDDQLQKLLADLHKREKELS-------LEKEQNKRLW-------------- 404

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   728 DMKKSHDAIIDDLNRKLldvtqkytekklemeklllenDSLSKDVSRLETVfvppekhekeIIALKSNIV-ELKKQLSEL 806
Cdd:pfam15921  405 DRDTGNSITIDHLRREL---------------------DDRNMEVQRLEAL----------LKAMKSECQgQMERQMAAI 453

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   807 KKKcGEDQEKIHALTSENTNLKKMMSnqyvpvKTHEEV---KMTLND---TLAKTNRELLDVKKKFEDINQEFVKIKDKN 880
Cdd:pfam15921  454 QGK-NESLEKVSSLTAQLESTKEMLR------KVVEELtakKMTLESserTVSDLTASLQEKERAIEATNAEITKLRSRV 526

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   881 EILKRNLENTQNQikAEYISLAEHEAKMSSLSQSMRkvqDSNAEILANYRKGQEEIVTLHAEIK-AQKKELDTIQECIKV 959
Cdd:pfam15921  527 DLKLQELQHLKNE--GDHLRNVQTECEALKLQMAEK---DKVIEILRQQIENMTQLVGQHGRTAgAMQVEKAQLEKEIND 601

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   960 KYAPIVSFEECERKFKATEKELKDQLS----EQTQKYSVSEEE---VKKNKQENDKLKKEIFTLQKDLRDKTVLIE---- 1028
Cdd:pfam15921  602 RRLELQEFKILKDKKDAKIRELEARVSdlelEKVKLVNAGSERlraVKDIKQERDQLLNEVKTSRNELNSLSEDYEvlkr 681

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1029 ----KSHEMERAlsrkTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHvplEQVEALKKSlngtI 1104
Cdd:pfam15921  682 nfrnKSEEMETT----TNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKR---GQIDALQSK----I 750

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1105 ENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEK---------EVGIIKASLREKEEESQNKME 1175
Cdd:pfam15921  751 QFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERrlkekvanmEVALDKASLQFAECQDIIQRQ 830

                          810
                   ....*....|..
gi 530406156  1176 EVSKLQSEVQNT 1187
Cdd:pfam15921  831 EQESVRLKLQHT 842
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 25-223 1.17e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 66.24  E-value: 1.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   25 LMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKG-NLECLNAILIHGVDITTSDTAGRNALHLAAKYG-HAL 102
Cdd:PHA02876  277 LHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKD 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  103 CLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP-TICQLLIDRGADVN 181
Cdd:PHA02876  357 IVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPyMSVKTLIDRGANVN 436

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 530406156  182 SRDKQNRTALMLGCEYGCR-DAVEVLIKNGADIS---------LLDALGHDS 223
Cdd:PHA02876  437 SKNKDLSTPLHYACKKNCKlDVIEMLLDNGADVNainiqnqypLLIALEYHG 488
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 458-1295 1.77e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 65.91  E-value: 1.77e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   458 ERVKEDSDEQIKqledalkDVQKRMYES------------------EGKVKQMQTHFLALKEHLTSEAASgnhrlTEELK 519
Cdd:pfam15921   77 ERVLEEYSHQVK-------DLQRRLNESnelhekqkfylrqsvidlQTKLQEMQMERDAMADIRRRESQS-----QEDLR 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   520 DQLKDLKVKYEGA-SAEVGKLRNQIKQNEMIVEEFKRDEGKlieenkrLQKELSMCEMEREKKGRKVTEMEgqakelsak 598
Cdd:pfam15921  145 NQLQNTVHELEAAkCLKEDMLEDSNTQIEQLRKMMLSHEGV-------LQEIRSILVDFEEASGKKIYEHD--------- 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   599 lalSIPAEKFENMKSSLSnevnekaKKLVEMEREHEKSLSEIRQLKRELENVKAKlAQHVKPEEHEQVKSRLEQKSGELG 678
Cdd:pfam15921  209 ---SMSTMHFRSLGSAIS-------KILRELDTEISYLKGRIFPVEDQLEALKSE-SQNKIELLLQQHQDRIEQLISEHE 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   679 KKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS--------EDMKKSHDAIIDDLNRKLLDVTQK 750
Cdd:pfam15921  278 VEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTvsqlrselREAKRMYEDKIEELEKQLVLANSE 357

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   751 YTEKKLEMEKLLLENDSLSkdvSRLETVFVPPEKHEKEIialksnivelkkQLSELKKKCGEDQEKIHALTSEntNLKKM 830
Cdd:pfam15921  358 LTEARTERDQFSQESGNLD---DQLQKLLADLHKREKEL------------SLEKEQNKRLWDRDTGNSITID--HLRRE 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   831 MSNQYVPVKTHEEVKMTL-NDTLAKTNRELLDVKKKFEDInQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMS 909
Cdd:pfam15921  421 LDDRNMEVQRLEALLKAMkSECQGQMERQMAAIQGKNESL-EKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVS 499

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   910 SLSQSM----RKVQDSNAEIlanyRKGQEEIVTLHAEIKAQKKELDTIQECIKvkyapivsfeECER-KFKATEKE---- 980
Cdd:pfam15921  500 DLTASLqekeRAIEATNAEI----TKLRSRVDLKLQELQHLKNEGDHLRNVQT----------ECEAlKLQMAEKDkvie 565

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   981 -LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL----SQKY 1055
Cdd:pfam15921  566 iLRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLvnagSERL 645

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1056 TEVKNVKE---KLVEENAKQTSEIlavQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKlhqlL 1132
Cdd:pfam15921  646 RAVKDIKQerdQLLNEVKTSRNEL---NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKS----M 718

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1133 ENQKNSSVPLAEHLQIK-EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvvdlSKYKATKSD 1211
Cdd:pfam15921  719 EGSDGHAMKVAMGMQKQiTAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEK----NKMAGELEV 794

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1212 LETQISSLNEKLANLNRKYEEVCEEVlhAKKKEISAKDEKELLHFSIEQEIkDQKERCDKSLTTITELQRRIQESAKQIE 1291
Cdd:pfam15921  795 LRSQERRLKEKVANMEVALDKASLQF--AECQDIIQRQEQESVRLKLQHTL-DVKELQGPGYTSNSSMKPRLLQPASFTR 871


                   ....
gi 530406156  1292 AKDN 1295
Cdd:pfam15921  872 THSN 875
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 40-216 2.28e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.63  E-value: 2.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   40 ILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGV---DITTSDtaGRNALHLAAKYGHALCLQKLLQYNCPTEH 116
Cdd:PHA02875   53 LLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKfadDVFYKD--GMTPLHLATILKKLDIMKLLIARGADPDI 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  117 ADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALM-LGC 195
Cdd:PHA02875  131 PNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALcYAI 210

                         170       180
                  ....*....|....*....|.
gi 530406156  196 EYGCRDAVEVLIKNGADISLL 216
Cdd:PHA02875  211 ENNKIDIVRLFIKRGADCNIM 231
PHA03095 PHA03095
ankyrin-like protein; Provisional
 106-221 2.29e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 64.66  E-value: 2.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  106 KLLQYNCPTEHADLQGRTALH---DAAMADCPSSIQLLCDHGASVNAKDVDGRTPL-VLATQMSRPTICQLLIDRGADVN 181
Cdd:PHA03095   32 RLLAAGADVNFRGEYGKTPLHlylHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVN 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 530406156  182 SRDKQNRTALMLGCEYGCRDA--VEVLIKNGADISLLDALGH 221
Cdd:PHA03095  112 AKDKVGRTPLHVYLSGFNINPkvIRLLLRKGADVNALDLYGM 153
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 25-248 2.49e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 2.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   25 LMKAAERGDVEKVTSILaKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCL 104
Cdd:PHA02874  128 LHYAIKKGDLESIKMLF-EYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACI 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  105 QKLLQYNCPTEHADLQGRTALHDAAMADcPSSIQLLCDHgASVNAKDVDGRTPLVLATQMS-RPTICQLLIDRGADVNSR 183
Cdd:PHA02874  207 KLLIDHGNHIMNKCKNGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIK 284

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530406156  184 DKQNRTALMLGCEYGCRDAV-------EVLIKNGADISLLDALGHDSsyyarIGDNLDILTLLKTASENTNK 248
Cdd:PHA02874  285 DNKGENPIDTAFKYINKDPVikdiianAVLIKEADKLKDSDFLEHIE-----IKDNKEFSDFIKECNEEIED 351
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 465-1278 3.44e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 64.66  E-value: 3.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   465 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSeaasgnhrlteeLKDQLKDLKvkyegasAEVGKLRNQIK 544
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINN------------SNNKIKILE-------QQIKDLNDKLK 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   545 QNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLalsipaEKFENMKSSLSNEVNEKAK 624
Cdd:TIGR04523   93 KNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEI------KKKEKELEKLNNKYNDLKK 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   625 KLVEMEREHEKSLSEIRQLKRELENVKAKLAqhvKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKvyldnkl 704
Cdd:TIGR04523  167 QKEELENELNLLEKEKLNIQKNIDKIKNKLL---KLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEK------- 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   705 LKEQAHNLTIEMKNHYVPLKvseDMKKSHDAIIDDLNRKLLDVTQkyTEKKLemeklllenDSLSKDVSRLETVF--VPP 782
Cdd:TIGR04523  237 KQQEINEKTTEISNTQTQLN---QLKDEQNKIKKQLSEKQKELEQ--NNKKI---------KELEKQLNQLKSEIsdLNN 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   783 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNqyvpvktheevkmtLNDTLAKTNRELLDV 862
Cdd:TIGR04523  303 QKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTN--------------SESENSEKQRELEEK 368

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   863 KKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQsmrkvqdsnaeilaNYRKGQEEIVTLHAE 942
Cdd:TIGR04523  369 QNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ--------------EKELLEKEIERLKET 434

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   943 IKAQKKELDTIQECIKVKyapivsfeecerkfKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLrd 1022
Cdd:TIGR04523  435 IIKNNSEIKDLTNQDSVK--------------ELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKEL-- 498

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1023 ktvliekshemeRALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPL--EQVEALKKSL 1100
Cdd:TIGR04523  499 ------------KKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELkkENLEKEIDEK 566

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1101 NGTIENLKEELKSMQRCYEKEQQtvtKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKL 1180
Cdd:TIGR04523  567 NKEIEELKQTQKSLKKKQEEKQE---LIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKL 643

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1181 QSEVQNTKQALKKLetrevvdlskyKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELL------ 1254
Cdd:TIGR04523  644 KQEVKQIKETIKEI-----------RNKWPEIIKKIKESKTKIDDIIELMKDWLKELSLHYKKYITRMIRIKDLpkleek 712

                          810       820
                   ....*....|....*....|....
gi 530406156  1255 HFSIEQEIKDQKErCDKSLTTITE 1278
Cdd:TIGR04523  713 YKEIEKELKKLDE-FSKELENIIK 735
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 934-1344 5.27e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 63.89  E-value: 5.27e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   934 EEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQK-------YSVSEEEVKKNKQEN 1006
Cdd:TIGR04523   40 KKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKinklnsdLSKINSEIKNDKEQK 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1007 DKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQ 1086
Cdd:TIGR04523  120 NKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKL 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1087 HVPLEQVEALK---KSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNssvplaEHLQIKEAFEKevgiIKASL 1163
Cdd:TIGR04523  200 ELLLSNLKKKIqknKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQT------QLNQLKDEQNK----IKKQL 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1164 REKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKY--------KATKSDLETQISSLNEKLANLNRKYEEVCE 1235
Cdd:TIGR04523  270 SEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKElkselknqEKKLEEIQNQISQNNKIISQLNEQISQLKK 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1236 EVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSL---TTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALN 1312
Cdd:TIGR04523  350 ELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKnleSQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIE 429

                          410       420       430
                   ....*....|....*....|....*....|..
gi 530406156  1313 GLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQ 1344
Cdd:TIGR04523  430 RLKETIIKNNSEIKDLTNQDSVKELIIKNLDN 461
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 606-1352 5.37e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 64.37  E-value: 5.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   606 EKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQlkrELENVKAKLAQHVKPEEHEQVKSRLEQKSGElgkkitelT 685
Cdd:pfam15921   74 EHIERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQ---SVIDLQTKLQEMQMERDAMADIRRRESQSQE--------D 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   686 LKNQtLQKEIEKVYLdNKLLKEQAhnltieMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKklemeklLLEN 765
Cdd:pfam15921  143 LRNQ-LQNTVHELEA-AKCLKEDM------LEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKK-------IYEH 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   766 DSLSKdvsrletvfvppeKHEKEIIALKSNIV-ELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQyvpvktHEEv 844
Cdd:pfam15921  208 DSMST-------------MHFRSLGSAISKILrELDTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQ------HQD- 267

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   845 kmTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKrnlENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAE 924
Cdd:pfam15921  268 --RIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQ---EQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYED 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   925 ILANYRKgqeEIVTLHAEIKAQKKELDtiqecikvkyapivsfeecerKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQ 1004
Cdd:pfam15921  343 KIEELEK---QLVLANSELTEARTERD---------------------QFSQESGNLDDQLQKLLADLHKREKELSLEKE 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1005 ENDKL-------KKEIFTLQKDLRDKTVLIEKsheMERALSRKTDELNKQLKdlsQKYTEVKNVKEKLvEENAKQTSEIL 1077
Cdd:pfam15921  399 QNKRLwdrdtgnSITIDHLRRELDDRNMEVQR---LEALLKAMKSECQGQME---RQMAAIQGKNESL-EKVSSLTAQLE 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1078 AVQNLLQKQhvpLEQVEALKKSLNG---TIENLKEELKSMQRCYEKEQQTVTKLH-------QLLENQKNSsvplAEHLQ 1147
Cdd:pfam15921  472 STKEMLRKV---VEELTAKKMTLESserTVSDLTASLQEKERAIEATNAEITKLRsrvdlklQELQHLKNE----GDHLR 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1148 IKEAfekEVGIIKASLREKE---EESQNKMEEVSKLQSE-------VQNTKQALKKLETREVVDLSKYKATKSDLETQIS 1217
Cdd:pfam15921  545 NVQT---ECEALKLQMAEKDkviEILRQQIENMTQLVGQhgrtagaMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIR 621

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1218 SLNEKLANLNRKyeevceevlhaKKKEISAKDEKELLHFSIEQE---IKDQKERCDKSLTTITE----LQRRIQESAKQI 1290
Cdd:pfam15921  622 ELEARVSDLELE-----------KVKLVNAGSERLRAVKDIKQErdqLLNEVKTSRNELNSLSEdyevLKRNFRNKSEEM 690

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530406156  1291 EAKDNKITELLNDVE-RLKQALNGLSQLTYTSGNPTK----RQSQL------IDTLQHQVKSLEQQLADADRQ 1352
Cdd:pfam15921  691 ETTTNKLKMQLKSAQsELEQTRNTLKSMEGSDGHAMKvamgMQKQItakrgqIDALQSKIQFLEEAMTNANKE 763
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 59-239 6.74e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.15  E-value: 6.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   59 FHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQK-----LLQYNCPTEHADLQGRTALHDAAMADC 133
Cdd:PHA03100   39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVKeivklLLEYGANVNAPDNNGITPLLYAISKKS 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  134 --PSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPT--ICQLLIDRGADVN----------------SRDKQNRTALML 193
Cdd:PHA03100  119 nsYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINaknrvnyllsygvpinIKDVYGFTPLHY 198

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 530406156  194 GCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL 239
Cdd:PHA03100  199 AVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 755-1346 7.16e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 63.98  E-value: 7.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   755 KLEMEKLLLENDSLSKDVSRleTVFVPPEKHEKEIIALKSNIVELKKQLSELK-------------KKCGED-----QEK 816
Cdd:pfam15921   73 KEHIERVLEEYSHQVKDLQR--RLNESNELHEKQKFYLRQSVIDLQTKLQEMQmerdamadirrreSQSQEDlrnqlQNT 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   817 IHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDV-----KKKFEDINQEFVKIKDKNEILKRNLENTQ 891
Cdd:pfam15921  151 VHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFeeasgKKIYEHDSMSTMHFRSLGSAISKILRELD 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   892 NQI---KAEYISLAEHEAKMSSLSQS-----MRKVQDSNAEILANYrkgQEEIVTLHAEIKAQKKELDTIQ---ECIKVK 960
Cdd:pfam15921  231 TEIsylKGRIFPVEDQLEALKSESQNkiellLQQHQDRIEQLISEH---EVEITGLTEKASSARSQANSIQsqlEIIQEQ 307

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   961 YAPIVSFEECE-RKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQendkLKKEIFTLQKDLRDKtvLIEKSHEMERALSR 1039
Cdd:pfam15921  308 ARNQNSMYMRQlSDLESTVSQLRSELREAKRMYEDKIEELEKQLV----LANSELTEARTERDQ--FSQESGNLDDQLQK 381

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1040 KTDELNKQLKDLSQKytevKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYE 1119
Cdd:pfam15921  382 LLADLHKREKELSLE----KEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKN 457

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1120 KEQQTVTKLHQLLENQKNSSVPLAEHLQIK----EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLE 1195
Cdd:pfam15921  458 ESLEKVSSLTAQLESTKEMLRKVVEELTAKkmtlESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLK 537

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1196 TREvVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQ---EIKDQKERCDKS 1272
Cdd:pfam15921  538 NEG-DHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDrrlELQEFKILKDKK 616

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1273 LTTITELQRRIQ----ESAKQIEAKDNKI----------TELLNDVERLKQALNGLSQ----LTYTSGNPTKRQSQLIDT 1334
Cdd:pfam15921  617 DAKIRELEARVSdlelEKVKLVNAGSERLravkdikqerDQLLNEVKTSRNELNSLSEdyevLKRNFRNKSEEMETTTNK 696

                          650
                   ....*....|..
gi 530406156  1335 LQHQVKSLEQQL 1346
Cdd:pfam15921  697 LKMQLKSAQSEL 708
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 903-1254 8.68e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 63.54  E-value: 8.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   903 EHEAKMSSLSQSMRKVQDSNAEILANYRK--GQEEIVTLHAEIKAQKKELDtiqecIKVKYAPIVSFEECERKFKATEKE 980
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSleRQAEKAERYKELKAELRELE-----LALLVLRLEELREELEELQEELKE 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   981 LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKN 1060
Cdd:TIGR02168  251 AEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELES 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1061 VKEKLVEEnakqtseilavqnllqkqhvpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsv 1140
Cdd:TIGR02168  331 KLDELAEE---------------------LAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSK-- 387

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1141 pLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNtkQALKKLETRevvdLSKYKATKSDLETQISSLN 1220
Cdd:TIGR02168  388 -VAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEE--AELKELQAE----LEELEEELEELQEELERLE 460

                          330       340       350
                   ....*....|....*....|....*....|....
gi 530406156  1221 EKLANLNRKYEEVCEEVLHAKKKEISAKDEKELL 1254
Cdd:TIGR02168  461 EALEELREELEEAEQALDAAERELAQLQARLDSL 494
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 67-227 9.73e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 62.67  E-value: 9.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   67 NLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGAS 146
Cdd:PHA02874  103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  147 VNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGcRDAVEVLIKNgADISLLDALGHDSSYY 226
Cdd:PHA02874  183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHH 260


                  .
gi 530406156  227 A 227
Cdd:PHA02874  261 A 261
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1017-1390 1.02e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.42  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1017 QKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEAL 1096
Cdd:COG1196   221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1097 KKSLNGTIENLKEELKSMQRcYEKEQQTVTKLHQLLENQknssvpLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEE 1176
Cdd:COG1196   301 EQDIARLEERRRELEERLEE-LEEELAELEEELEELEEE------LEELEEELEEAEEELEEAEAELAEAEEALLEAEAE 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1177 VSKLQSEVQNTKQALKKLETREVVDLSKYKAtksdLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAkdekellhf 1256
Cdd:COG1196   374 LAEAEEELEELAEELLEALRAAAELAAQLEE----LEEAEEALLERLERLEEELEELEEALAELEEEEEEE--------- 440

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1257 siEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTytsgnpTKRQSQLIDTLQ 1336
Cdd:COG1196   441 --EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKA 512

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530406156 1337 HQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL 1390
Cdd:COG1196   513 ALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYL 566
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 438-1115 1.66e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 62.35  E-value: 1.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   438 KLQNELAHKVAECKAL---ALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNhrl 514
Cdd:TIGR04523   44 TIKNELKNKEKELKNLdknLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKN--- 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   515 teELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEgqaKE 594
Cdd:TIGR04523  121 --KLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIK---NK 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   595 LSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVkpEEHEQVKSRLEQKS 674
Cdd:TIGR04523  196 LLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLK--DEQNKIKKQLSEKQ 273

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   675 GEL---GKKITELTLKNQTLQKEIEKvyLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY 751
Cdd:TIGR04523  274 KELeqnNKKIKELEKQLNQLKSEISD--LNNQKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKEL 351

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   752 TEKKLEMEKLlleNDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMM 831
Cdd:TIGR04523  352 TNSESENSEK---QRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEI 428

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   832 SNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSL 911
Cdd:TIGR04523  429 ERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKEL 508

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   912 SQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIqecikvkyapivsfeecerkfkatekelkdqlsEQTQK 991
Cdd:TIGR04523  509 EEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKD---------------------------------DFELK 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   992 YSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKshemeraLSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAK 1071
Cdd:TIGR04523  556 KENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQ-------KEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEK 628

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 530406156  1072 QTSEIlavQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQ 1115
Cdd:TIGR04523  629 LSSII---KNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIK 669
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 888-1364 1.81e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 62.43  E-value: 1.81e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   888 ENTQNQIKAEYISLAEHEAKMSSLSQSMRkVQDSNAEILANYRKGQEEIVTLHAEiKAQKKELDTIQECIKVKYAPIVSF 967
Cdd:pfam05483  175 EYEREETRQVYMDLNNNIEKMILAFEELR-VQAENARLEMHFKLKEDHEKIQHLE-EEYKKEINDKEKQVSLLLIQITEK 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   968 EECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI----FTLQKDLRDKTVLIEKSHEMERALSRKTDE 1043
Cdd:pfam05483  253 ENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELedikMSLQRSMSTQKALEEDLQIATKTICQLTEE 332

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1044 LNKQLKDLSQKYTEVKNVKEKLveenakqTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYE---- 1119
Cdd:pfam05483  333 KEAQMEELNKAKAAHSFVVTEF-------EATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNnkev 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1120 --KEQQTVTKLHQLLENQKNSSVPLAEHLQIKE--------AFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKq 1189
Cdd:pfam05483  406 elEELKKILAEDEKLLDEKKQFEKIAEELKGKEqelifllqAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEK- 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1190 aLKKLETREVVDL-----SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKD 1264
Cdd:pfam05483  485 -LKNIELTAHCDKlllenKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDE 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1265 QKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQ 1344
Cdd:pfam05483  564 VKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLEL 643

                          490       500
                   ....*....|....*....|
gi 530406156  1345 QLADADRQHQEVIAIYRTHL 1364
Cdd:pfam05483  644 ELASAKQKFEEIIDNYQKEI 663
PTZ00121 PTZ00121
MAEBL; Provisional
 864-1309 3.97e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 61.70  E-value: 3.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  864 KKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDsNAEILANYRKGQEEIVTLHAEI 943
Cdd:PTZ00121 1194 RKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERN-NEEIRKFEEARMAHFARRQAAI 1272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  944 KAQ-KKELDTIQECIKVKYAPIVSFEECERKF-----KATEKELKDQLSEQTQKYSVSEEEVKKNKQENdklKKEIFTLQ 1017
Cdd:PTZ00121 1273 KAEeARKADELKKAEEKKKADEAKKAEEKKKAdeakkKAEEAKKADEAKKKAEEAKKKADAAKKKAEEA---KKAAEAAK 1349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1018 KDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKE--KLVEENAKQTSEILAVQNLLQKQHVPLEQVEA 1095
Cdd:PTZ00121 1350 AEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEakKKAEEDKKKADELKKAAAAKKKADEAKKKAEE 1429

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1096 LKKSlngtiENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQiKEAFEKEVGiikASLREKEEESQNKME 1175
Cdd:PTZ00121 1430 KKKA-----DEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAK-KKAEEAKKA---DEAKKKAEEAKKKAD 1500

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1176 EVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLnRKYEEV--CEEVLHAKKKEiSAKDEKEL 1253
Cdd:PTZ00121 1501 EAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADEL-KKAEELkkAEEKKKAEEAK-KAEEDKNM 1578

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530406156 1254 LHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQ 1309
Cdd:PTZ00121 1579 ALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKK 1634
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 137-234 5.04e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 60.68  E-value: 5.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  137 IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLL 216
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177

                          90
                  ....*....|....*...
gi 530406156  217 DALGHDSSYYARIGDNLD 234
Cdd:PTZ00322  178 GANAKPDSFTGKPPSLED 195
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 288-1178 6.66e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 60.76  E-value: 6.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   288 IENEDLKERLRKIQQEQRILLDKVNGLQLQLNEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRK 367
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQEL 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   368 EDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAmrtfcESAKQDRLKLQNELAHKV 447
Cdd:pfam02463  246 LRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSEL-----LKLERRKVDDEEKLKESE 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   448 AECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSeaasgNHRLTEELKDQLKDLKV 527
Cdd:pfam02463  321 KEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAK-----KKLESERLSSAAKLKEE 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   528 KYEGASAEVGKLRNQIkqnemivEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLAlsipaek 607
Cdd:pfam02463  396 ELELKSEEEKEAQLLL-------ELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLL------- 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   608 fENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRE-LENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTL 686
Cdd:pfam02463  462 -KDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSqKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVEN 540

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   687 -KNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKS----------HDAIIDDLNRKLLDVTQKYTEKK 755
Cdd:pfam02463  541 yKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLklplksiavlEIDPILNLAQLDKATLEADEDDK 620

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   756 LEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQY 835
Cdd:pfam02463  621 RAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLE 700

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   836 VPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQ--IKAEYISLAEHEAKMSSLSQ 913
Cdd:pfam02463  701 IKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKkeEKEEEKSELSLKEKELAEER 780

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   914 SMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVsfEECERKFKATEKELKDQLSEQTQKYS 993
Cdd:pfam02463  781 EKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKE--EELEELALELKEEQKLEKLAEEELER 858

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   994 VSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQT 1073
Cdd:pfam02463  859 LEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPE 938

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1074 SEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFE 1153
Cdd:pfam02463  939 ELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQR 1018

                          890       900
                   ....*....|....*....|....*
gi 530406156  1154 KEVGIIKASLREKEEESQNKMEEVS 1178
Cdd:pfam02463 1019 LKEFLELFVSINKGWNKVFFYLELG 1043
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 624-1317 2.07e-08

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 59.21  E-value: 2.07e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   624 KKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKsgELGKKITELTLKNQTLQKEIEKVYLDNK 703
Cdd:pfam02463  169 RKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEK--LELEEEYLLYLDYLKLNEERIDLLQELL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   704 LLKEQAHNLTI-EMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVfvpP 782
Cdd:pfam02463  247 RDEQEEIESSKqEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKE---K 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   783 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEE----VKMTLNDTLAKTNRE 858
Cdd:pfam02463  324 KKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESErlssAAKLKEEELELKSEE 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   859 LLDVKKKFEDINQEFVKIKDKNEILKRNLENTQ--NQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEI 936
Cdd:pfam02463  404 EKEAQLLLELARQLEDLLKEEKKEELEILEEEEesIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQ 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   937 VTLHAEIKAQKKELDTIQEC----------IKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEN 1006
Cdd:pfam02463  484 EQLELLLSRQKLEERSQKESkarsglkvllALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEER 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1007 DKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT--DELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEI-------- 1076
Cdd:pfam02463  564 QKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEidPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTklkesaka 643

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1077 --------------------LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQK 1136
Cdd:pfam02463  644 kesglrkgvsleeglaekseVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELL 723

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1137 NSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV---VDLSKYKATKSDLE 1213
Cdd:pfam02463  724 ADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLkveEEKEEKLKAQEEEL 803

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1214 TQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRR--IQESAKQIE 1291
Cdd:pfam02463  804 RALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELllKEEELEEQK 883

                          730       740
                   ....*....|....*....|....*.
gi 530406156  1292 AKDNKITELLNDVERLKQALNGLSQL 1317
Cdd:pfam02463  884 LKDELESKEEKEKEEKKELEEESQKL 909
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 540-1366 2.24e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 58.90  E-value: 2.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   540 RNQIKQNEMIVEEFKRDEGKLIEENKRLQKELS-MCEMEREKKGRKVT--EMEGQAKELSAKLALSIPA--EKFENMKSS 614
Cdd:TIGR00606  230 EAQLESSREIVKSYENELDPLKNRLKEIEHNLSkIMKLDNEIKALKSRkkQMEKDNSELELKMEKVFQGtdEQLNDLYHN 309

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   615 LSNEVNEKAKKLVEMEREHEKSLSEIRQL---KRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKI--------TE 683
Cdd:TIGR00606  310 HQRTVREKERELVDCQRELEKLNKERRLLnqeKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELdgfergpfSE 389

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   684 LTLKN-QTLQKE--IEKVYLDNKLLKEQAHNLTIEMKNhyvpLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK 760
Cdd:TIGR00606  390 RQIKNfHTLVIErqEDEAKTAAQLCADLQSKERLKQEQ----ADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQ 465

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   761 LLLENDSLSKDVSRLETVFVPPEKHEKE--IIALKSNIVELK-KQLSELKKKCGEDQEkIHALTSENTNLKKMMSNQYVP 837
Cdd:TIGR00606  466 LEGSSDRILELDQELRKAERELSKAEKNslTETLKKEVKSLQnEKADLDRKLRKLDQE-MEQLNHHTTTRTQMEMLTKDK 544

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   838 VKTHEEV--------------------KMTLNDTLAKTNRELLDVKKKFEDINQEFVKikdkneilkrnLENTQNQIKAE 897
Cdd:TIGR00606  545 MDKDEQIrkiksrhsdeltsllgyfpnKKQLEDWLHSKSKEINQTRDRLAKLNKELAS-----------LEQNKNHINNE 613

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   898 YISLaehEAKMSSLSQSMRKVQDSNAEilanyrkgQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEE-------- 969
Cdd:TIGR00606  614 LESK---EEQLSSYEDKLFDVCGSQDE--------ESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDenqsccpv 682

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   970 CERKFKaTEKELKDQLSEQTQKYSV-------SEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTD 1042
Cdd:TIGR00606  683 CQRVFQ-TEAELQEFISDLQSKLRLapdklksTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQ 761

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1043 ELNKQLKDlSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGT----------------IEN 1106
Cdd:TIGR00606  762 RLKNDIEE-QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGSDLDrtvqqvnqekqekqheLDT 840

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1107 LKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEvgiikasLREKEEESQNKMEEVSKLQSEVQN 1186
Cdd:TIGR00606  841 VVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQ-------LVELSTEVQSLIREIKDAKEQDSP 913

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1187 TKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN-------LNRKYEEVCEEVLHAKKKEISA------------ 1247
Cdd:TIGR00606  914 LETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNihgymkdIENKIQDGKDDYLKQKETELNTvnaqleecekhq 993

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1248 -KDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELlnDVERLKQALNGLSQLTYTSGNPTK 1326
Cdd:TIGR00606  994 eKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQM--QVLQMKQEHQKLEENIDLIKRNHV 1071

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*
gi 530406156  1327 ----RQSQLIDTLQHQVKSL-EQQLADADRQHQEVIAIYRTHLLS 1366
Cdd:TIGR00606 1072 lalgRQKGYEKEIKHFKKELrEPQFRDAEEKYREMMIVMRTTELV 1116
PRK01156 PRK01156
chromosome segregation protein; Provisional
 609-1196 2.48e-08

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 58.76  E-value: 2.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  609 ENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLaQHVKPEEHE-----QVKSRLEQKSGELGKKITE 683
Cdd:PRK01156  189 EEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDY-NNLKSALNElssleDMKNRYESEIKTAESDLSM 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  684 LTLKNQTLqKEIEKVYldNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNR-----KLLDVTQKYTEKKLEM 758
Cdd:PRK01156  268 ELEKNNYY-KELEERH--MKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKyhaiiKKLSVLQKDYNDYIKK 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  759 EKlllENDSLSKDVSRLETvfvppekHEKEIIALKSNIVELKKQLSELKKKcgedQEKIHALTSENtnLKKMMSNQYVPV 838
Cdd:PRK01156  345 KS---RYDDLNNQILELEG-------YEMDYNSYLKSIESLKKKIEEYSKN----IERMSAFISEI--LKIQEIDPDAIK 408

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  839 KTHEEVkmtlndtlaktNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLsqsMRKV 918
Cdd:PRK01156  409 KELNEI-----------NVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSVCPVCGTTLGEEKSNHI---INHY 474

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  919 QDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQEcikvkyAPIVSFEECERKFKATEKELKD------QLSEQTQKY 992
Cdd:PRK01156  475 NEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLES------EEINKSINEYNKIESARADLEDikikinELKDKHDKY 548

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  993 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDkTVLIEkshemerALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQ 1072
Cdd:PRK01156  549 EEIKNRYKSLKLEDLDSKRTSWLNALAVIS-LIDIE-------TNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKS 620

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1073 TSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsvplaehlqikeaf 1152
Cdd:PRK01156  621 IREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKS-------------- 686

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....
gi 530406156 1153 EKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLET 1196
Cdd:PRK01156  687 RKALDDAKANRARLESTIEILRTRINELSDRINDINETLESMKK 730
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 36-209 3.25e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 57.97  E-value: 3.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   36 KVTSILAKKGVNPGKLDVE-GRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPT 114
Cdd:PHA02878  148 EITKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  115 EHADLQGRTALHdAAMADCPSS--IQLLCDHGASVNAKD-VDGRTPLVLATQMSRPTicQLLIDRGADVNSRDKQNRTAL 191
Cdd:PHA02878  228 DARDKCGNTPLH-ISVGYCKDYdiLKLLLEHGVDVNAKSyILGLTALHSSIKSERKL--KLLLEYGADINSLNSYKLTPL 304

                         170
                  ....*....|....*....
gi 530406156  192 -MLGCEYGCRDAVEVLIKN 209
Cdd:PHA02878  305 sSAVKQYLCINIGRILISN 323
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 28-244 5.06e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 57.38  E-value: 5.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   28 AAERGDVeKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHlaakygHALCLQKL 107
Cdd:PHA02876  185 AAERGNA-KMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLSLLKAIR------NEDLETSL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  108 LQYNC--PTEHADLQGRTALHDAAMAdcPSSIQL---LCDHGASVNAKDVDGRTPLVLATQMSRPTI-CQLLIDRGADVN 181
Cdd:PHA02876  258 LLYDAgfSVNSIDDCKNTPLHHASQA--PSLSRLvpkLLERGADVNAKNIKGETPLYLMAKNGYDTEnIRTLIMLGADVN 335

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530406156  182 SRDKQNRTALMLGCEYG-CRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDIL-TLLKTASE 244
Cdd:PHA02876  336 AADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIInTLLDYGAD 400
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 586-1014 7.40e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 57.39  E-value: 7.40e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   586 TEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQ-HVKPEEH 663
Cdd:TIGR02169  670 RSEPAELQRLRERLeGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEElEEDLSSL 749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   664 EQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYldNKLLKEQAHNLTIEMKNhyvplkvSEDMKKSHDAIIDDLNRK 743
Cdd:TIGR02169  750 EQEIENVKSELKELEARIEELEEDLHKLEEALNDLE--ARLSHSRIPEIQAELSK-------LEEEVSRIEARLREIEQK 820

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   744 LldvtqkyteKKLEMEKLLLENDSlskdvsrletvfvppEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKihaltse 823
Cdd:TIGR02169  821 L---------NRLTLEKEYLEKEI---------------QELQEQRIDLKEQIKSIEKEIENLNGKKEELEEE------- 869

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   824 ntnlkkmmsnqyvpvktheevkmtlndtLAKTNRELLDVKKKFEDINQEFVKIKDKneilKRNLENTQNQIKAEYISLAE 903
Cdd:TIGR02169  870 ----------------------------LEELEAALRDLESRLGDLKKERDELEAQ----LRELERKIEELEAQIEKKRK 917

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   904 HeakMSSLSQSMRKVQDSNAEILANYRKGQEE------IVTLHAEIKAQKKELDTIQEcikVKYAPIVSFEECERKFkat 977
Cdd:TIGR02169  918 R---LSELKAKLEALEEELSEIEDPKGEDEEIpeeelsLEDVQAELQRVEEEIRALEP---VNMLAIQEYEEVLKRL--- 988

                          410       420       430
                   ....*....|....*....|....*....|....*..
gi 530406156   978 ekelkDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIF 1014
Cdd:TIGR02169  989 -----DELKEKRAKLEEERKAILERIEEYEKKKREVF 1020
Ank_4 pfam13637
Ankyrin repeats (many copies);
121-174 8.72e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 8.72e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 530406156   121 GRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLI 174
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 66-247 9.53e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.15  E-value: 9.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   66 GNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGA 145
Cdd:PHA02875   13 GELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  146 SVNakDV---DGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHD 222
Cdd:PHA02875   93 FAD--DVfykDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCT 170

                         170       180
                  ....*....|....*....|....*
gi 530406156  223 SSYYARIGDNLDILTLLKTASENTN 247
Cdd:PHA02875  171 PLIIAMAKGDIAICKMLLDSGANID 195
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 608-876 1.06e-07

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 56.47  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  608 FENMKSSLSNEVNEKAKKLVEMEREHeksLSEIRQLkRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLK 687
Cdd:PRK05771   33 IEDLKEELSNERLRKLRSLLTKLSEA---LDKLRSY-LPKLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  688 NQTLQKEIEKvYLDNKLLKEQAHNLTIEMKNHY-------VPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY------TEK 754
Cdd:PRK05771  109 ISELENEIKE-LEQEIERLEPWGNFDLDLSLLLgfkyvsvFVGTVPEDKLEELKLESDVENVEYISTDKGYvyvvvvVLK 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  755 KL--EMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 832
Cdd:PRK05771  188 ELsdEVEEELKKLGFERLELEEEGTPSELIREIKEELEEIEKERESLLEELKELAKKYLEELLALYEYLEIELERAEALS 267

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530406156  833 NQ-----------YVPVKTHEEVKMTLNDTlakTNR----ELLDVKKKFEDI-----NQEFVKI 876
Cdd:PRK05771  268 KFlktdktfaiegWVPEDRVKKLKELIDKA---TGGsayvEFVEPDEEEEEVptklkNPKFIKP 328
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 848-1347 1.19e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.48  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  848 LNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILA 927
Cdd:COG1196   237 LEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEE 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  928 NYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEND 1007
Cdd:COG1196   317 RLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAA 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1008 KLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKqh 1087
Cdd:COG1196   397 ELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAAL-- 474

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1088 vpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHqLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASL---- 1163
Cdd:COG1196   475 --LEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAAL-LLAGLRGLAGAVAVLIGVEAAYEAALEAALAAAlqni 551

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1164 ---------REKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVD-------------------LSKYKATKSDLETQ 1215
Cdd:COG1196   552 vveddevaaAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGaavdlvasdlreadaryyvLGDTLLGRTLVAAR 631

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1216 ISSLNEKLANLNRKYEEV---CEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEA 1292
Cdd:COG1196   632 LEAALRRAVTLAGRLREVtleGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAE 711

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530406156 1293 KDNKITELLNDVERLKQALNGLSQ-----------LTYTSGNPTKRQSQLIDTLQHQVKSLEQQLA 1347
Cdd:COG1196   712 AEEERLEEELEEEALEEQLEAEREelleelleeeeLLEEEALEELPEPPDLEELERELERLEREIE 777
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 414-807 1.32e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.28  E-value: 1.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   414 ENEILKKeLEAMRTFCESAKQDRLKLQNELAHKvaeckalalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 493
Cdd:pfam15921  456 KNESLEK-VSSLTAQLESTKEMLRKVVEELTAK-----------KMTLESSERTVSDLTASLQEKERAIEATNAEITKLR 523

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   494 THF-LALKE--HLTSEAASGNHRLTEelkdqLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKE 570
Cdd:pfam15921  524 SRVdLKLQElqHLKNEGDHLRNVQTE-----CEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKE 598

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   571 LSMCEMEREKKGRKVTEMEGQAKELSAKLAlsipaeKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENV 650
Cdd:pfam15921  599 INDRRLELQEFKILKDKKDAKIRELEARVS------DLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSL 672

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   651 KaklaqhvkpEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIekvyldnkllkEQAHNLTIEMK-NHYVPLKVSEDM 729
Cdd:pfam15921  673 S---------EDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSEL-----------EQTRNTLKSMEgSDGHAMKVAMGM 732

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   730 KKSHDAI---IDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSrleTVFVPPEKHEKEIIALKSNIVELKKQLSEL 806
Cdd:pfam15921  733 QKQITAKrgqIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELS---TVATEKNKMAGELEVLRSQERRLKEKVANM 809


                   .
gi 530406156   807 K 807
Cdd:pfam15921  810 E 810
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
881-1309 2.00e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 55.82  E-value: 2.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  881 EILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVK 960
Cdd:PRK02224  254 ETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEEC 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  961 YAPIVSF-EECERKFKATE------KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEM 1033
Cdd:PRK02224  334 RVAAQAHnEEAESLREDADdleeraEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDF 413

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1034 ERALSRKTDELNKQLKDLSQKYTEVKNVKEK---LVE-----------ENAKQTSEILAVQNLLQKQHVPLEQVEALKKS 1099
Cdd:PRK02224  414 LEELREERDELREREAELEATLRTARERVEEaeaLLEagkcpecgqpvEGSPHVETIEEDRERVEELEAELEDLEEEVEE 493

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1100 LNGTIENLkEELKSMQRCYEKEQQTVTKLHQLLENQKNS----SVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1175
Cdd:PRK02224  494 VEERLERA-EDLVEAEDRIERLEERREDLEELIAERRETieekRERAEELRERAAELEAEAEEKREAAAEAEEEAEEARE 572

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1176 EVSKLQSEVQNTKQALKKLETREVVDlskykATKSDLETQISSLNEKLANLNRKYEEVCEEVlhAKKKEISAKDEKELLH 1255
Cdd:PRK02224  573 EVAELNSKLAELKERIESLERIRTLL-----AAIADAEDEIERLREKREALAELNDERRERL--AEKRERKRELEAEFDE 645

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530406156 1256 FSIEqEIKDQKERCDKSLTTITELQRRIQES----AKQIEAKDNKITELLNDVERLKQ 1309
Cdd:PRK02224  646 ARIE-EAREDKERAEEYLEQVEEKLDELREErddlQAEIGAVENELEELEELRERREA 702
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 274-1345 2.68e-07

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 55.83  E-value: 2.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   274 KSHQREHQNIQDLEIENEDLK------ERLRKIQQEQRILLDKVN--------GLQLQLNEREKLKSLLAAKEKQHEE-- 337
Cdd:TIGR01612  904 KSIEEEYQNINTLKKVDEYIKicentkESIEKFHNKQNILKEILNknidtikeSNLIEKSYKDKFDNTLIDKINELDKaf 983

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   338 ---SLRTIEALKNRF-KYFESDHLGSGSHfsnrKEDMLLKQ------------GQMYMADSQCTSPGIPAHMQSRSMLRP 401
Cdd:TIGR01612  984 kdaSLNDYEAKNNELiKYFNDLKANLGKN----KENMLYHQfdekekatndieQKIEDANKNIPNIEIAIHTSIYNIIDE 1059

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   402 LELSLPSQTSYSENEILKKELEAMRTFCESakQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKR 481
Cdd:TIGR01612 1060 IEKEIGKNIELLNKEILEEAEINITNFNEI--KEKLKHYNFDDFGKEENIKYADEINKIKDDIKNLDQKIDHHIKALEEI 1137

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   482 MYESEGKVKQMQTHFLALkEHLTSEAASGNHrlTEELKDQLKDLKVKYEGAS---AEVGKLRNQIKQNEMIVEEFKRDEG 558
Cdd:TIGR01612 1138 KKKSENYIDEIKAQINDL-EDVADKAISNDD--PEEIEKKIENIVTKIDKKKniyDEIKKLLNEIAEIEKDKTSLEEVKG 1214

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   559 KLIEENKRLQKE-LSMCEMEREKKGRKVTEMEGQAKEL------SAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMER 631
Cdd:TIGR01612 1215 INLSYGKNLGKLfLEKIDEEKKKSEHMIKAMEAYIEDLdeikekSPEIENEMGIEMDIKAEMETFNISHDDDKDHHIISK 1294

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   632 EHEKSLSEIRQ--LKRELENVKAKLAQHVKPEEHEQVkSRLEQKSGELGKKITELT-----LKNQTLQKEIEKVYLDNKL 704
Cdd:TIGR01612 1295 KHDENISDIREksLKIIEDFSEESDINDIKKELQKNL-LDAQKHNSDINLYLNEIAniyniLKLNKIKKIIDEVKEYTKE 1373

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   705 LKEQAHNLTIEMKNHYVPLKVSED---MKKSHDAIIDDLNRKLLD-VTQKYTEKKLEMEKLLLENDSL-------SKDVS 773
Cdd:TIGR01612 1374 IEENNKNIKDELDKSEKLIKKIKDdinLEECKSKIESTLDDKDIDeCIKKIKELKNHILSEESNIDTYfknadenNENVL 1453

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   774 RLETVFVPPEKHEKEIIALKS---------NIVELKKQLSElKKKCGEDQEKIHALTSENTNLKK-------MMSNQYVP 837
Cdd:TIGR01612 1454 LLFKNIEMADNKSQHILKIKKdnatndhdfNINELKEHIDK-SKGCKDEADKNAKAIEKNKELFEqykkdvtELLNKYSA 1532

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   838 VKTHEEVKMTLNDTLAKTNrELLDVKKKF----EDINQEFVKIKDKNEILKRNLENTQNQIKAEY---ISLAEHEAKMSS 910
Cdd:TIGR01612 1533 LAIKNKFAKTKKDSEIIIK-EIKDAHKKFileaEKSEQKIKEIKKEKFRIEDDAAKNDKSNKAAIdiqLSLENFENKFLK 1611

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   911 LSQSMRKVQDSNAEILANYRK-GQEEIVTLHAEIKAQKKELDTIQECIKvkyapivSFEECERKFKATEKELkDQLSEQT 989
Cdd:TIGR01612 1612 ISDIKKKINDCLKETESIEKKiSSFSIDSQDTELKENGDNLNSLQEFLE-------SLKDQKKNIEDKKKEL-DELDSEI 1683

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   990 QKYSVSEEEVKKNKQEN--DKLKKEIFTLQKDLRDKTVLIEKSheMERALS-------------RKTDELNKQLKDLSQK 1054
Cdd:TIGR01612 1684 EKIEIDVDQHKKNYEIGiiEKIKEIAIANKEEIESIKELIEPT--IENLISsfntndlegidpnEKLEEYNTEIGDIYEE 1761

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1055 YTEVKNV---------KEKLVEENAKQT-----SEILAVQNLLQKQHVPLEQVEAlkKSLNGTIENLKEELKSMQRCYEK 1120
Cdd:TIGR01612 1762 FIELYNIiagcletvsKEPITYDEIKNTrinaqNEFLKIIEIEKKSKSYLDDIEA--KEFDRIINHFKKKLDHVNDKFTK 1839

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1121 EQQTVTK----LHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQS----EVQNTkQALK 1192
Cdd:TIGR01612 1840 EYSKINEgfddISKSIENVKNSTDENLLFDILNKTKDAYAGIIGKKYYSYKDEAEKIFINISKLANsiniQIQNN-SGID 1918

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1193 KLETREVVDLSKYKATKSDLETQISSlNEKLANLNRKYEEVCEEVLHA-KKKEISAKDEKELLHFSIEQEIKDQKERCDK 1271
Cdd:TIGR01612 1919 LFDNINIAILSSLDSEKEDTLKFIPS-PEKEPEIYTKIRDSYDTLLDIfKKSQDLHKKEQDTLNIIFENQQLYEKIQASN 1997

                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530406156  1272 SLttitelqrriQESAKQIEAKDNKItelLNDVERLKQALNGLSQLTYTSGN-PTKRQSQLIDTLQHQVKSLEQQ 1345
Cdd:TIGR01612 1998 EL----------KDTLSDLKYKKEKI---LNDVKLLLHKFDELNKLSCDSQNyDTILELSKQDKIKEKIDNYEKE 2059
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 783-1023 4.39e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.00  E-value: 4.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  783 EKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNqyvpvktheevkmtLNDTLAKTNRELLDV 862
Cdd:COG4942    23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA--------------LEQELAALEAELAEL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  863 KKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAE 942
Cdd:COG4942    89 EKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAE 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  943 IKAQKKELDTIQEcikvkyapivSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD 1022
Cdd:COG4942   169 LEAERAELEALLA----------ELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238


                  .
gi 530406156 1023 K 1023
Cdd:COG4942   239 A 239
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 21-213 4.96e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.30  E-value: 4.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   21 YDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTsdtagrnalhLAAKYGh 100
Cdd:PHA02876  341 YITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEA----------LSQKIG- 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  101 alclqkllqyncptehadlqgrTALHDAAMADCP-SSIQLLCDHGASVNAKDVDGRTPLVLATQMS-RPTICQLLIDRGA 178
Cdd:PHA02876  410 ----------------------TALHFALCGTNPyMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGA 467

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 530406156  179 DVNSRDKQNRTALMLGCEYgcRDAVEVLIKNGADI 213
Cdd:PHA02876  468 DVNAINIQNQYPLLIALEY--HGIVNILLHYGAEL 500
Ank_4 pfam13637
Ankyrin repeats (many copies);
55-108 6.26e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 6.26e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 530406156    55 GRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLL 108
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
286-708 9.71e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 53.53  E-value: 9.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  286 LEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFEsdhlgsgshfsn 365
Cdd:PRK03918  298 LSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYE------------ 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  366 rKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELslpsqtsysENEIlkKELEAMRTFCESAKQDRLKLQNELah 445
Cdd:PRK03918  366 -EAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEI---------EEEI--SKITARIGELKKEIKELKKAIEEL-- 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  446 KVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAA-SGNHRLTEELKDQLKD 524
Cdd:PRK03918  432 KKAKGKCPVCGRELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESElIKLKELAEQLKELEEK 511

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  525 LKV-----------KYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQ---KELSMCEMEREKKGRK-VTEME 589
Cdd:PRK03918  512 LKKynleelekkaeEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDeleEELAELLKELEELGFEsVEELE 591

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  590 GQAKELsaklalsipaEKFENMKSSLSN---EVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVK---PEEH 663
Cdd:PRK03918  592 ERLKEL----------EPFYNEYLELKDaekELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKkysEEEY 661

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 530406156  664 EQVKSRLEQKSGELGKKITELtlknQTLQKEIEKVYLDNKLLKEQ 708
Cdd:PRK03918  662 EELREEYLELSRELAGLRAEL----EELEKRREEIKKTLEKLKEE 702
PRK01156 PRK01156
chromosome segregation protein; Provisional
 755-1312 1.71e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 52.60  E-value: 1.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  755 KLEMEKLLLEN--DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMS 832
Cdd:PRK01156  163 SLERNYDKLKDviDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALN 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  833 NQyvpvktheevkMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLS 912
Cdd:PRK01156  243 EL-----------SSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKK 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  913 QSMRKVQDSNAEILANYRKgQEEIVTLHAEIKAQKKELDTIQECI------KVKYAPIV-SFEECERKFKATEKELKDQL 985
Cdd:PRK01156  312 QILSNIDAEINKYHAIIKK-LSVLQKDYNDYIKKKSRYDDLNNQIlelegyEMDYNSYLkSIESLKKKIEEYSKNIERMS 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  986 SEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLK------DLSQKYTEvk 1059
Cdd:PRK01156  391 AFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSVcpvcgtTLGEEKSN-- 468

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1060 NVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGtiENLKEelksmqrcYEKEQQTVTKLHQLLENQKNSS 1139
Cdd:PRK01156  469 HIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLES--EEINK--------SINEYNKIESARADLEDIKIKI 538

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1140 VPLAE-HLQIKEAFEKEVGIIKASLREKEEESQNKMEEVS-----KLQSEVQNTKQALKKLETREVVDLSKYKATKSDLE 1213
Cdd:PRK01156  539 NELKDkHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAVISlidieTNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYID 618

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1214 TQISSLNEKLANLNRKYEEVCE-----EVLHAK----KKEISAKDEkellhfsIEQEIKDQKERCDKSLTTITELQRRIQ 1284
Cdd:PRK01156  619 KSIREIENEANNLNNKYNEIQEnkiliEKLRGKidnyKKQIAEIDS-------IIPDLKEITSRINDIEDNLKKSRKALD 691

                         570       580
                  ....*....|....*....|....*...
gi 530406156 1285 ESAKQIEAKDNKITELLNDVERLKQALN 1312
Cdd:PRK01156  692 DAKANRARLESTIEILRTRINELSDRIN 719
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 864-1078 1.92e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.69  E-value: 1.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  864 KKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEI 943
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  944 KAQKKE----LDTIQECIKVKY-APIVSFEECERKFKATE--KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTL 1016
Cdd:COG4942   100 EAQKEElaelLRALYRLGRQPPlALLLSPEDFLDAVRRLQylKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530406156 1017 QKDLRDK----TVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILA 1078
Cdd:COG4942   180 LAELEEEraalEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 137-239 2.22e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.80  E-value: 2.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  137 IQLLCDHGASVNAKDVD-GRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISL 215
Cdd:PHA02878  150 TKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                          90       100
                  ....*....|....*....|....*...
gi 530406156  216 LDALG----HDSSYYARigdNLDILTLL 239
Cdd:PHA02878  230 RDKCGntplHISVGYCK---DYDILKLL 254
PTZ00121 PTZ00121
MAEBL; Provisional
 419-894 2.30e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.45  E-value: 2.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  419 KKELEAMRTFCESAKQDRLKLQNELahKVAECKALALECERVKEDSD------EQIKQLEDALKDVQKRMYESEGKVKQM 492
Cdd:PTZ00121 1533 AKKADEAKKAEEKKKADELKKAEEL--KKAEEKKKAEEAKKAEEDKNmalrkaEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  493 QthflaLKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEgkliEENKRLQKELS 572
Cdd:PTZ00121 1611 E-----AKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKA----EEDKKKAEEAK 1681

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  573 MCEMEREKKGRKVTEMEgqakelsaklalsipaekfenmksslsnevnEKAKKLVEMEREHEKSLSEIRQLKRELENVKA 652
Cdd:PTZ00121 1682 KAEEDEKKAAEALKKEA-------------------------------EEAKKAEELKKKEAEEKKKAEELKKAEEENKI 1730

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  653 KLAQHVKPEEHEQVKSRLEQKSGELGKKIteltlknQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMK-- 730
Cdd:PTZ00121 1731 KAEEAKKEAEEDKKKAEEAKKDEEEKKKI-------AHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKdi 1803

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  731 KSHDAIIDDLNRKlldvTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIvelKKQLSELKKKC 810
Cdd:PTZ00121 1804 FDNFANIIEGGKE----GNLVINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGN---KEADFNKEKDL 1876

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  811 GEDQEKIHALTSENTNLKKMMSNQYVPvktheevkmtlNDTLAKTNRELLDVKkkfedinqefvkiKDKNEILKRNLENT 890
Cdd:PTZ00121 1877 KEDDEEEIEEADEIEKIDKDDIEREIP-----------NNNMAGKNNDIIDDK-------------LDKDEYIKRDAEET 1932


                  ....
gi 530406156  891 QNQI 894
Cdd:PTZ00121 1933 REEI 1936
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 92-220 2.73e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.94  E-value: 2.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   92 LHLAAKYGHALCLQKLLQYNcpteHADLQ-----GRTALHDAAMADCPSSIQLLCDhgasvNAKDV----------DGRT 156
Cdd:cd22192    21 LLLAAKENDVQAIKKLLKCP----SCDLFqrgalGETALHVAALYDNLEAAVVLME-----AAPELvnepmtsdlyQGET 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530406156  157 PLVLATQMSRPTICQLLIDRGADVNSRD------KQNRTALMLGCEY--------GCRDAVEVLIKNGADISLLDALG 220
Cdd:cd22192    92 ALHIAVVNQNLNLVRELIARGADVVSPRatgtffRPGPKNLIYYGEHplsfaacvGNEEIVRLLIEHGADIRAQDSLG 169
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 266-1195 3.53e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 51.97  E-value: 3.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   266 HMQDEVNVKSHQREHQN--IQDLEIENEDLKERLRKIQQEQRILL---DKVNGLQLQLNEREKLKSLLaaKEKQHEESLR 340
Cdd:TIGR00606  221 EIRDQITSKEAQLESSReiVKSYENELDPLKNRLKEIEHNLSKIMkldNEIKALKSRKKQMEKDNSEL--ELKMEKVFQG 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   341 TIEALKNRFKYFESDHLGSGSHFS--------NRKEDMLLKQGQMYM----ADSQCTSPGIPAHMQSRSMLRpLELSLPS 408
Cdd:TIGR00606  299 TDEQLNDLYHNHQRTVREKERELVdcqrelekLNKERRLLNQEKTELlveqGRLQLQADRHQEHIRARDSLI-QSLATRL 377

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   409 QTSYSENE-ILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALAlecervkedsDEQIKQLEDALKDVQKRMYESEG 487
Cdd:TIGR00606  378 ELDGFERGpFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLK----------QEQADEIRDEKKGLGRTIELKKE 447

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   488 KVKQMQTHFLALKEHLTSEAASGNH--RLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMI-VEEFKRDEGKLIEEN 564
Cdd:TIGR00606  448 ILEKKQEELKFVIKELQQLEGSSDRilELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKAdLDRKLRKLDQEMEQL 527

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   565 KRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIP----AEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEI 640
Cdd:TIGR00606  528 NHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGyfpnKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNK 607

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   641 RQLKRELENVKAKLaqhvkpeeheqvkSRLEQKSGEL-GKKITELTLKNqtLQKEIEKVYLDNKLLKEQAH-------NL 712
Cdd:TIGR00606  608 NHINNELESKEEQL-------------SSYEDKLFDVcGSQDEESDLER--LKEEIEKSSKQRAMLAGATAvysqfitQL 672

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   713 TIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIAL 792
Cdd:TIGR00606  673 TDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSII---DLKEKEIPEL 749

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   793 KSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVK--------MTLNDTLAKTNRELLDVKK 864
Cdd:TIGR00606  750 RNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKdverkiaqQAAKLQGSDLDRTVQQVNQ 829

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   865 KFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQdsnaeilanyrKGQEEIVTLHAEik 944
Cdd:TIGR00606  830 EKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQ-----------QFEEQLVELSTE-- 896

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   945 aqkkeldtIQECIKvkyapivSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKT 1024
Cdd:TIGR00606  897 --------VQSLIR-------EIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIE 961

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1025 VLIEKSheMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLveENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTI 1104
Cdd:TIGR00606  962 NKIQDG--KDDYLKQKETELNTVNAQLEECEKHQEKINEDM--RLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEEL 1037

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1105 ENLKEELKSMQRCYEKeqQTVTKLHQLLENQKNSSVPLAEHLQikeAFEKEVGIIKASLREKeeESQNKMEEVSKLQSEV 1184
Cdd:TIGR00606 1038 KQHLKEMGQMQVLQMK--QEHQKLEENIDLIKRNHVLALGRQK---GYEKEIKHFKKELREP--QFRDAEEKYREMMIVM 1110

                          970
                   ....*....|.
gi 530406156  1185 QNTKQALKKLE 1195
Cdd:TIGR00606 1111 RTTELVNKDLD 1121
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 873-1345 3.64e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 51.89  E-value: 3.64e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   873 FVKIKDKNEILKRNLENTQNQIKAeyisLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDT 952
Cdd:TIGR00618  367 IREISCQQHTLTQHIHTLQQQKTT----LTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAEL 442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   953 ----IQECIKVKYAPIVSFEECERKFKATEKELKD--QLSEQTQKYSVSEEEVKKNKQENDK-LKKEIFTLQKDLRDKTV 1025
Cdd:TIGR00618  443 caaaITCTAQCEKLEKIHLQESAQSLKEREQQLQTkeQIHLQETRKKAVVLARLLELQEEPCpLCGSCIHPNPARQDIDN 522

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1026 LIEKSHEMERALSRKT-------------DELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQ 1092
Cdd:TIGR00618  523 PGPLTRRMQRGEQTYAqletseedvyhqlTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEK 602

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1093 VEALKKSLNGTIENLKEELK----------SMQRCYEKEQQTVTKLHQLLENQKNSSVplAEHLQIKEAFEKEVGiikAS 1162
Cdd:TIGR00618  603 LSEAEDMLACEQHALLRKLQpeqdlqdvrlHLQQCSQELALKLTALHALQLTLTQERV--REHALSIRVLPKELL---AS 677

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1163 LREKEEESQNKMEEVSKLQSEVQNTKQALKKLET------REVVDLSKYKAT-KSDLETQISSLNEKLANLNRKYEEVCE 1235
Cdd:TIGR00618  678 RQLALQKMQSEKEQLTYWKEMLAQCQTLLRELEThieeydREFNEIENASSSlGSDLAAREDALNQSLKELMHQARTVLK 757

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1236 E--VLHAKKKEISAKDEKELLHFS-IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLndVERLKQALN 1312
Cdd:TIGR00618  758 ArtEAHFNNNEEVTAALQTGAELShLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETL--VQEEEQFLS 835

                          490       500       510
                   ....*....|....*....|....*....|...
gi 530406156  1313 GLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQ 1345
Cdd:TIGR00618  836 RLEEKSATLGEITHQLLKYEECSKQLAQLTQEQ 868
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
923-1374 3.89e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 51.31  E-value: 3.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  923 AEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKvKYAPIVSFEECERKFKATEKELKdQLSEQTQKYSVSEEEVKKN 1002
Cdd:COG4717    84 EEKEEEYAELQEELEELEEELEELEAELEELREELE-KLEKLLQLLPLYQELEALEAELA-ELPERLEELEERLEELREL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1003 KQENDKLKKEIFTLQKDLRDKtvLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKL--VEENAKQTSEILAVQ 1080
Cdd:COG4717   162 EEELEELEAELAELQEELEEL--LEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELeeLEEELEQLENELEAA 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1081 NLLQKQHVPLEQ---------VEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA 1151
Cdd:COG4717   240 ALEERLKEARLLlliaaallaLLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEE 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1152 fekEVGIIKASLREKEEESQnkmEEVSKLQSEVQNTKQALKKLETREvvdlskYKATKSDLETQISSLnekLANLNRKYE 1231
Cdd:COG4717   320 ---ELEELLAALGLPPDLSP---EELLELLDRIEELQELLREAEELE------EELQLEELEQEIAAL---LAEAGVEDE 384

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1232 EVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKslTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1311
Cdd:COG4717   385 EELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEA--LDEEELEEELEELEEELEELEEELEELREELAELEAEL 462

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530406156 1312 NGLsqltytsgnptkRQSQLIDTLQHQVKSLEQQLADADRQHQeVIAIYRTHLLSAAQGHMDE 1374
Cdd:COG4717   463 EQL------------EEDGELAELLQELEELKAELRELAEEWA-ALKLALELLEEAREEYREE 512
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 461-1229 4.46e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 51.51  E-value: 4.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   461 KEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAasgnhrLTEELKDQLKDLKVKYEGASAEVGKLR 540
Cdd:TIGR00618  159 KAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQL------LTLCTPCMPDTYHERKQVLEKELKHLR 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   541 NQIKQnEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKkgrkvtemegqAKELSAKLALSIPAEKFENMKSSLSnevn 620
Cdd:TIGR00618  233 EALQQ-TQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEE-----------LRAQEAVLEETQERINRARKAAPLA---- 296

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   621 EKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQksgelgkkitelTLKNQTLQKEIE-KVY 699
Cdd:TIGR00618  297 AHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQ------------TLHSQEIHIRDAhEVA 364

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   700 LDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVF 779
Cdd:TIGR00618  365 TSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCA 444

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   780 VPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQ------EKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLA 853
Cdd:TIGR00618  445 AAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEqihlqeTRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPG 524

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   854 KTNRELLdvkkkfedinqefvKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQ 933
Cdd:TIGR00618  525 PLTRRMQ--------------RGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQ 590

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   934 EEIVTLHAEIKAQKKEldtiqecikvkyapivsfeecERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDK---LK 1010
Cdd:TIGR00618  591 NITVRLQDLTEKLSEA---------------------EDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKltaLH 649

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1011 KEIFTLQKDLRDKTVLIEKSHEMERALSRKtdelnKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPL 1090
Cdd:TIGR00618  650 ALQLTLTQERVREHALSIRVLPKELLASRQ-----LALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIE 724

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1091 EQVEALKKSLNGTIENLKEELKSMQRcyekEQQTVTKLHQLLENQKNSSVPLAEHLQIKEA--------FEKEVGIIKAS 1162
Cdd:TIGR00618  725 NASSSLGSDLAAREDALNQSLKELMH----QARTVLKARTEAHFNNNEEVTAALQTGAELShlaaeiqfFNRLREEDTHL 800

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1163 LREKEEESQNKME--------EVSKLQSEVQNTKQALKKLET---------REVVDLSKYKATKSDLETQISSLNEKLAN 1225
Cdd:TIGR00618  801 LKTLEAEIGQEIPsdedilnlQCETLVQEEEQFLSRLEEKSAtlgeithqlLKYEECSKQLAQLTQEQAKIIQLSDKLNG 880


                   ....
gi 530406156  1226 LNRK 1229
Cdd:TIGR00618  881 INQI 884
PHA02798 PHA02798
ankyrin-like protein; Provisional
 137-235 5.46e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 50.60  E-value: 5.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  137 IQLLCDHGASVNAKDVDGRTPLV-----LATQMSRPTICQLLIDRGADVNSRDKQNRTAL--MLGCEY-GCRDAVEVLIK 208
Cdd:PHA02798   54 VKLFINLGANVNGLDNEYSTPLCtilsnIKDYKHMLDIVKILIENGADINKKNSDGETPLycLLSNGYiNNLEILLFMIE 133

                          90       100
                  ....*....|....*....|....*...
gi 530406156  209 NGADISLLDALGHDS-SYYARIGDNLDI 235
Cdd:PHA02798  134 NGADTTLLDKDGFTMlQVYLQSNHHIDI 161
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 926-1226 5.53e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.09  E-value: 5.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  926 LANYRKGQEEIVTLHAEIKAQKKELDTIQecikvkyapivsfeecerkfkATEKELKDQLSEQTQKYSVSEEEVKKNKQE 1005
Cdd:COG1196   231 LLKLRELEAELEELEAELEELEAELEELE---------------------AELAELEAELEELRLELEELELELEEAQAE 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1006 NDKLKKEIFTLQKDlrdktvlIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQK 1085
Cdd:COG1196   290 EYELLAELARLEQD-------IARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1086 QhvpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEvgiiKASLRE 1165
Cdd:COG1196   363 A---EEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA----LAELEE 435

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530406156 1166 KEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANL 1226
Cdd:COG1196   436 EEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLL 496
Ank_2 pfam12796
Ankyrin repeats (3 copies);
158-239 5.84e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.88  E-value: 5.84e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   158 LVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGAdislLDALGHDSS--YYARIGDNLDI 235
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD----VNLKDNGRTalHYAARSGHLEI 76


                   ....
gi 530406156   236 LTLL 239
Cdd:pfam12796   77 VKLL 80
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 973-1291 7.18e-06

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 50.60  E-value: 7.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  973 KFKATEKELKD---QLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD--KTVLiEKSHEMERALsrktDELNKQ 1047
Cdd:PRK04778   99 RFRKAKHEINEiesLLDLIEEDIEQILEELQELLESEEKNREEVEQLKDLYRElrKSLL-ANRFSFGPAL----DELEKQ 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1048 LKDLSQKYTEVKNVKEklvEENAKQTSEILAVQ----NLLQKQ--HVPlEQVEALKKSLNGTIENLKEELKSMQRC-YEK 1120
Cdd:PRK04778  174 LENLEEEFSQFVELTE---SGDYVEAREILDQLeeelAALEQImeEIP-ELLKELQTELPDQLQELKAGYRELVEEgYHL 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1121 EQQTVTKLHQLLENQKNSSVPLAEHLQIKEAfEKEVGIIKA------SLREKEEESQNKMEE-VSKLQSEVQNTKQALKK 1193
Cdd:PRK04778  250 DHLDIEKEIQDLKEQIDENLALLEELDLDEA-EEKNEEIQEridqlyDILEREVKARKYVEKnSDTLPDFLEHAKEQNKE 328

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1194 LETR-EVVDLSkYKATKSDLETQiSSLNEKLANLNRKYEEVCEEVlhaKKKEISakdekellhFSieqEIKDQKERCDKS 1272
Cdd:PRK04778  329 LKEEiDRVKQS-YTLNESELESV-RQLEKQLESLEKQYDEITERI---AEQEIA---------YS---ELQEELEEILKQ 391

                         330
                  ....*....|....*....
gi 530406156 1273 LTTITELQRRIQESAKQIE 1291
Cdd:PRK04778  392 LEEIEKEQEKLSEMLQGLR 410
PHA03095 PHA03095
ankyrin-like protein; Provisional
 137-213 9.12e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 9.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  137 IQLLCDHGASVNAKDVDGRTPLVLATQMS---RPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCR-DAVEVLIKNGAD 212
Cdd:PHA03095   30 VRRLLAAGADVNFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIKAGAD 109


                  .
gi 530406156  213 I 213
Cdd:PHA03095  110 V 110
COG5022 COG5022
Myosin heavy chain [General function prediction only];
787-1317 1.02e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 50.46  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  787 KEIIALKSNIVELKKQLSELKKKCGED-QEKIHALTSENTNLKKMMSNqyVPVKTHEEVKMTLNDTLAKtnreLLDVKKK 865
Cdd:COG5022   892 KSISSLKLVNLELESEIIELKKSLSSDlIENLEFKTELIARLKKLLNN--IDLEEGPSIEYVKLPELNK----LHEVESK 965

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  866 FEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQS---MRKVQDSNAEILANYRKGQEEIVTLHAE 942
Cdd:COG5022   966 LKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQEStkqLKELPVEVAELQSASKIISSESTELSIL 1045

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  943 IKAQK-------KELDTIQECIKVKYAPIVSFEEC------------ERKFKATEKELKDQ-----------LSEQTQKY 992
Cdd:COG5022  1046 KPLQKlkgllllENNQLQARYKALKLRRENSLLDDkqlyqlestenlLKTINVKDLEVTNRnlvkpanvlqfIVAQMIKL 1125

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  993 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMER----ALSRKTDELNKQLKDLSQKYT----EVKNVKEK 1064
Cdd:COG5022  1126 NLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALpsppPFAALSEKRLYQSALYDEKSKlsssEVNDLKNE 1205

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1065 LVEENAKQTSEIL---AVQNLLQKQHVPLEQVEALKKSLNG----------TIENLKEELKSMQRCYEKEQQTVTKLHQL 1131
Cdd:COG5022  1206 LIALFSKIFSGWPrgdKLKKLISEGWVPTEYSTSLKGFNNLnkkfdtpasmSNEKLLSLLNSIDNLLSSYKLEEEVLPAT 1285

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1132 LENQ-KNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvVDLSKYKATKS 1210
Cdd:COG5022  1286 INSLlQYINVGLFNALRTKASSLRWKSATEVNYNSEELDDWCREFEISDVDEELEELIQAVKVLQLLK-DDLNKLDELLD 1364

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1211 DLETQissLNEKLANLNRKYEevCEEVLHAKKKEISAKDEkellhfsieqeikdqKERCDKSLTTITELQRRIQESAKQI 1290
Cdd:COG5022  1365 ACYSL---NPAEIQNLKSRYD--PADKENNLPKEILKKIE---------------ALLIKQELQLSLEGKDETEVHLSEI 1424

                         570       580
                  ....*....|....*....|....*..
gi 530406156 1291 EAKDNKITELLNDVERLKQALNGLSQL 1317
Cdd:COG5022  1425 FSEEKSLISLDRNSIYKEEVLSSLSAL 1451
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1008-1259 1.04e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 49.93  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1008 KLKK-EIFTLqKDLRDKTVliEKSHEMERA--LSRKTDELNKQLKDLSQKYTEVKNVKEKL--------VEENAKQTSEI 1076
Cdd:PRK05771    5 RMKKvLIVTL-KSYKDEVL--EALHELGVVhiEDLKEELSNERLRKLRSLLTKLSEALDKLrsylpklnPLREEKKKVSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1077 LAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSmqrcYEKEQQTVTKLH------QLLENQKNSSVPLAEhlqIKE 1150
Cdd:PRK05771   82 KSLEELIKDVEEELEKIEKEIKELEEEISELENEIKE----LEQEIERLEPWGnfdldlSLLLGFKYVSVFVGT---VPE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1151 AFEKEVGIIKaSLREKEEESQNKMEE-----VSKLQSEVQNTkqALKKLETREVV---------DLSKYKATKSDLETQI 1216
Cdd:PRK05771  155 DKLEELKLES-DVENVEYISTDKGYVyvvvvVLKELSDEVEE--ELKKLGFERLEleeegtpseLIREIKEELEEIEKER 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 530406156 1217 SSLNEKLANLNRKYEE---VCEEVL--HAKKKEISAKDEKELLHFSIE 1259
Cdd:PRK05771  232 ESLLEELKELAKKYLEellALYEYLeiELERAEALSKFLKTDKTFAIE 279
PRK01156 PRK01156
chromosome segregation protein; Provisional
 979-1357 1.09e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 50.29  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  979 KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEV 1058
Cdd:PRK01156  172 KDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMK 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1059 KNVKEKLVEENAKQTSEILAVQNL--LQKQHVPLEQVEALKK--------SLNGTIENLKEELKSMQRCYEKEQQTVTKL 1128
Cdd:PRK01156  252 NRYESEIKTAESDLSMELEKNNYYkeLEERHMKIINDPVYKNrnyindyfKYKNDIENKKQILSNIDAEINKYHAIIKKL 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1129 HQL-------LENQKNSSVPLAEHLQIKEAFEKEVGIIKA--SLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREv 1199
Cdd:PRK01156  332 SVLqkdyndyIKKKSRYDDLNNQILELEGYEMDYNSYLKSieSLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKE- 410

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1200 vdLSKYKATKSDLETQISSLNEKLANLNRKYEE---------------VCEEVLHAKKKEISAKD--------EKELLHF 1256
Cdd:PRK01156  411 --LNEINVKLQDISSKVSSLNQRIRALRENLDElsrnmemlngqsvcpVCGTTLGEEKSNHIINHynekksrlEEKIREI 488

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1257 SIEQEIKDQKERCDKSLTTITELQ--RRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLT--------------YT 1320
Cdd:PRK01156  489 EIEVKDIDEKIVDLKKRKEYLESEeiNKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKnrykslkledldskRT 568

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 530406156 1321 SGNPTKRQSQLID--TLQHQVKSLEQQLADADRQHQEVI 1357
Cdd:PRK01156  569 SWLNALAVISLIDieTNRSRSNEIKKQLNDLESRLQEIE 607
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 466-698 1.35e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  466 EQIKQLEDALKDVQKRMYESEGKVKQMQthflalkehltseaasgnhRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 545
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALK-------------------KEEKALLKQLAALERRIAALARRIRALEQELAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  546 NEMIVEEFKRDEGKLIEENKRLQKELSmcEMERekkgrkVTEMEGQAKELSAKLALSIPAEKFENMK---------SSLS 616
Cdd:COG4942    81 LEAELAELEKEIAELRAELEAQKEELA--ELLR------ALYRLGRQPPLALLLSPEDFLDAVRRLQylkylaparREQA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  617 NEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKpeEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIE 696
Cdd:COG4942   153 EELRADLAELAALRAELEAERAELEALLAELEEERAALEALKA--ERQKLLARLEKELAELAAELAELQQEAEELEALIA 230


                  ..
gi 530406156  697 KV 698
Cdd:COG4942   231 RL 232
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 465-777 1.57e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.55  E-value: 1.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  465 DEQIKQLE-DALKDVQKRMYESEGKVKQMQTHFLALKEhLTSEAASGNHRLtEELKDQLKDLKVKYEGASAEVGKLRNQI 543
Cdd:COG1196   199 ERQLEPLErQAEKAERYRELKEELKELEAELLLLKLRE-LEAELEELEAEL-EELEAELEELEAELAELEAELEELRLEL 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  544 KQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALsipaekfenmkssLSNEVNEKA 623
Cdd:COG1196   277 EELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEE-------------LEEELEELE 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  624 KKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDN 702
Cdd:COG1196   344 EELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEElEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEEL 423

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530406156  703 KLLKEQAHNLTIEMKNHyvpLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLET 777
Cdd:COG1196   424 EELEEALAELEEEEEEE---EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL 495
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1035-1251 1.59e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.06  E-value: 1.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1035 RALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQnllqkqhvplEQVEALKKSLNGTIENLKEELKSM 1114
Cdd:COG3883    26 SELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQ----------AEIAEAEAEIEERREELGERARAL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1115 QRcyekEQQTVTKLHQLLENQKNSSVplaehlqikeafekevgIIKASLREKEEESQNK-MEEVSKLQSEVQNTKQALKK 1193
Cdd:COG3883    96 YR----SGGSVSYLDVLLGSESFSDF-----------------LDRLSALSKIADADADlLEELKADKAELEAKKAELEA 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530406156 1194 LETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVcEEVLHAKKKEISAKDEK 1251
Cdd:COG3883   155 KLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAA-EAQLAELEAELAAAEAA 211
COG5022 COG5022
Myosin heavy chain [General function prediction only];
921-1302 1.60e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 49.69  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  921 SNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIV-SFEECERKFKATEKELKDQLSEQTQK-------- 991
Cdd:COG5022   804 SLLGSRKEYRSYLACIIKLQKTIKREKKLRETEEVEFSLKAEVLIqKFGRSLKAKKRFSLLKKETIYLQSAQrvelaerq 883

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  992 ---YSVSEEEVKKNKQENDKLKKEIF----TLQKDLRDKT-VLIEKSHEMERALS------------RKTDELNK----- 1046
Cdd:COG5022   884 lqeLKIDVKSISSLKLVNLELESEIIelkkSLSSDLIENLeFKTELIARLKKLLNnidleegpsieyVKLPELNKlheve 963

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1047 -QLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLngtiENLKEELKSMQRCYEKEQQTV 1125
Cdd:COG5022   964 sKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQESTKQL----KELPVEVAELQSASKIISSES 1039

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1126 TKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQnkMEEVSKLQSEVQNTKQALKKLET---REVVDL 1202
Cdd:COG5022  1040 TELSILKPLQKLKGLLLLENNQLQARYKALKLRRENSLLDDKQLYQ--LESTENLLKTINVKDLEVTNRNLvkpANVLQF 1117

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1203 SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTI-TELQR 1281
Cdd:COG5022  1118 IVAQMIKLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAALSEKRLYQSALYDEKsKLSSS 1197

                         410       420
                  ....*....|....*....|.
gi 530406156 1282 RIQESAKQIEAKDNKITELLN 1302
Cdd:COG5022  1198 EVNDLKNELIALFSKIFSGWP 1218
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
466-664 1.76e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.53  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  466 EQIKQLEDALKDVQKrmYEsegKVKQMQTHFLALKEHLTSEAAsgnHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQ 545
Cdd:COG4913   249 EQIELLEPIRELAER--YA---AARERLAELEYLRAALRLWFA---QRRLELLEAELEELRAELARLEAELERLEARLDA 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  546 NEMIVEEFKR----DEGKLIEenkRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPA------------EKFE 609
Cdd:COG4913   321 LREELDELEAqirgNGGDRLE---QLEREIERLERELEERERRRARLEALLAALGLPLPASAEEfaalraeaaallEALE 397

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530406156  610 NMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR-------ELENVKAKLAQHVKPEEHE 664
Cdd:COG4913   398 EELEALEEALAEAEAALRDLRRELRELEAEIASLERrksnipaRLLALRDALAEALGLDEAE 459
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 64-191 1.96e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 49.24  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   64 SKGNLECLNAILI-HGVDITTSDTAGRNALHLAAKYGHALCLQKLLQ-----YNCPTEHADLQGRTALHDAAMADCPSSI 137
Cdd:cd22192    26 KENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEaapelVNEPMTSDLYQGETALHIAVVNQNLNLV 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530406156  138 QLLCDHGASVNAKDVD--------------GRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTAL 191
Cdd:cd22192   106 RELIARGADVVSPRATgtffrpgpknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 514-807 2.02e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.16  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  514 LTEELKDQLKDLK-----------VKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 582
Cdd:COG1196   194 ILGELERQLEPLErqaekaeryreLKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  583 RKVTEMEGQAKELSAKL-ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQH---- 657
Cdd:COG1196   274 LELEELELELEEAQAEEyELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAeeel 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  658 ----VKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHyvplkvsEDMKKSH 733
Cdd:COG1196   354 eeaeAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERL-------EEELEEL 426

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530406156  734 DAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQLSELK 807
Cdd:COG1196   427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEA---ALLEAALAELLEELAEAAARLLLLL 497
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 469-1354 2.25e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 49.02  E-value: 2.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   469 KQLEDALKDVQKRMYESEGKVKQMQThfLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEvgkLRNQIKQNEM 548
Cdd:pfam01576  155 KLLEERISEFTSNLAEEEEKAKSLSK--LKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTD---LQEQIAELQA 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   549 IVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPA-EKFENMKSSLSNEVnEKAKKLV 627
Cdd:pfam01576  230 QIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAArNKAEKQRRDLGEEL-EALKTEL 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   628 EMEREHEKSLSEIRQlKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKvylDNKLLKE 707
Cdd:pfam01576  309 EDTLDTTAAQQELRS-KREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEK---AKQALES 384

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   708 QAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVppeKHEK 787
Cdd:pfam01576  385 ENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNI---KLSK 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   788 EIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQyvpvkthEEVKMTLNDTLAKTNRELLDVKKKFE 867
Cdd:pfam01576  462 DVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQLSDMKKKLE 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   868 DINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKV---QDSNAEILANYRKGQEEIVTLHAEIK 944
Cdd:pfam01576  535 EDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLlvdLDHQRQLVSNLEKKQKKFDQMLAEEK 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   945 AqkkeldtiqecIKVKYApivsfEECER-KFKATEKELKD-QLSEQTQKYSVSEEEVKKNkqeNDKLKKEIFTL--QKDL 1020
Cdd:pfam01576  615 A-----------ISARYA-----EERDRaEAEAREKETRAlSLARALEEALEAKEELERT---NKQLRAEMEDLvsSKDD 675

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1021 RDKTVlieksHEME---RALSRKTDELNKQLKDLSQkytevknvkEKLVEENAKQTSEIlavqnllqkqhvpleQVEALK 1097
Cdd:pfam01576  676 VGKNV-----HELErskRALEQQVEEMKTQLEELED---------ELQATEDAKLRLEV---------------NMQALK 726

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1098 KSLNGTIENLKEELKsmqrcyEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEV 1177
Cdd:pfam01576  727 AQFERDLQARDEQGE------EKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAVKQL 800

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1178 SKLQSEVQNTKQALK--KLETREVVDLSKYKATKS-DLETQISSLNEKLANLNR-------KYEEVCEEVLHAKKKEISA 1247
Cdd:pfam01576  801 KKLQAQMKDLQRELEeaRASRDEILAQSKESEKKLkNLEAELLQLQEDLAASERarrqaqqERDELADEIASGASGKSAL 880

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1248 KDEKELLhfsiEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGL--------SQLTY 1319
Cdd:pfam01576  881 QDEKRRL----EARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLerqnkelkAKLQE 956

                          890       900       910
                   ....*....|....*....|....*....|....*
gi 530406156  1320 TSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQ 1354
Cdd:pfam01576  957 MEGTVKSKFKSSIAALEAKIAQLEEQLEQESRERQ 991
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 995-1229 2.36e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.22  E-value: 2.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  995 SEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTS 1074
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1075 EILAVQNLLQKQHV---PLEQVEALKKSLNGtiENLKEELKSMQRcyekeqqtvtkLHQLLENQKNSSVPLAEHLQIKEA 1151
Cdd:COG4942    98 ELEAQKEELAELLRalyRLGRQPPLALLLSP--EDFLDAVRRLQY-----------LKYLAPARREQAEELRADLAELAA 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530406156 1152 FEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRK 1229
Cdd:COG4942   165 LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 692-1335 3.06e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 48.89  E-value: 3.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   692 QKEIEKvyldNKLLKEQAHNLTIEMKNHYVPLKVSEDM---KKSHDAIID---DLNRKLLDVTQKYTEK--KLEMEKLLL 763
Cdd:TIGR01612 1506 AKAIEK----NKELFEQYKKDVTELLNKYSALAIKNKFaktKKDSEIIIKeikDAHKKFILEAEKSEQKikEIKKEKFRI 1581

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   764 ENDSLSKDVSRLETVFVPPEKHEKEIIALKsnIVELKKQLSELKKKCGEDQEKIHALT--SENTNLKKMMSNqyvpVKTH 841
Cdd:TIGR01612 1582 EDDAAKNDKSNKAAIDIQLSLENFENKFLK--ISDIKKKINDCLKETESIEKKISSFSidSQDTELKENGDN----LNSL 1655

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   842 EEVKMTLNDTlaKTNREllDVKKKFEDINQEFVKIKDKNEILKRNLE-NTQNQIKAEYISlaeHEAKMSSLSQSmrkVQD 920
Cdd:TIGR01612 1656 QEFLESLKDQ--KKNIE--DKKKELDELDSEIEKIEIDVDQHKKNYEiGIIEKIKEIAIA---NKEEIESIKEL---IEP 1725

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   921 SNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKD-QLSEQTQKYSVSEEEV 999
Cdd:TIGR01612 1726 TIENLISSFNTNDLEGIDPNEKLEEYNTEIGDIYEEFIELYNIIAGCLETVSKEPITYDEIKNtRINAQNEFLKIIEIEK 1805

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1000 KKNKQENDKLKKEIFTLQKDLRDKTvlieksHEMERALSRKTDELNKQLKDLSQKYTEVKN-VKEKLVEENAKQTSEILA 1078
Cdd:TIGR01612 1806 KSKSYLDDIEAKEFDRIINHFKKKL------DHVNDKFTKEYSKINEGFDDISKSIENVKNsTDENLLFDILNKTKDAYA 1879

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1079 vqNLLQKQHVP--------LEQVEALKKSLNGTIEN------LKEELKSMQRCYEKEQQTVTKLHQLLENQKNSsvplae 1144
Cdd:TIGR01612 1880 --GIIGKKYYSykdeaekiFINISKLANSINIQIQNnsgidlFDNINIAILSSLDSEKEDTLKFIPSPEKEPEI------ 1951

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1145 HLQIKEAFEKEVGIIKAS--LREKEEESQNKMEEVSKLQSEVQNTKqalkklETREVVDLSKYKATK--SDLETQISSLN 1220
Cdd:TIGR01612 1952 YTKIRDSYDTLLDIFKKSqdLHKKEQDTLNIIFENQQLYEKIQASN------ELKDTLSDLKYKKEKilNDVKLLLHKFD 2025

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1221 E--KLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKIT 1298
Cdd:TIGR01612 2026 ElnKLSCDSQNYDTILELSKQDKIKEKIDNYEKEKEKFGIDFDVKAMEEKFDNDIKDIEKFENNYKHSEKDNHDFSEEKD 2105

                          650       660       670
                   ....*....|....*....|....*....|....*..
gi 530406156  1299 ELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTL 1335
Cdd:TIGR01612 2106 NIIQSKKKLKELTEAFNTEIKIIEDKIIEKNDLIDKL 2142
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
458-656 4.12e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 48.09  E-value: 4.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  458 ERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalKEH----LTSEAASGNHRLTeELKDQLKDLKVKYEGAS 533
Cdd:COG3206   167 ELRREEARKALEFLEEQLPELRKELEEAEAALEEFR------QKNglvdLSEEAKLLLQQLS-ELESQLAEARAELAEAE 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  534 AEVGKLRNQIKQNEMIVEEFKRDegkliEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLAlsipaekfeNMKS 613
Cdd:COG3206   240 ARLAALRAQLGSGPDALPELLQS-----PVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIA---------ALRA 305

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 530406156  614 SLSNEVnekAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQ 656
Cdd:COG3206   306 QLQQEA---QRILASLEAELEALQAREASLQAQLAQLEARLAE 345
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 724-1097 5.02e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 47.70  E-value: 5.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  724 KVSEDMKKSHDAIIDDLNRKLLDVTQKYTeKKLEMEKLLLENDSLSKDVSRLETVFvppEKHEKEIIALKSNIVELKKQL 803
Cdd:NF033838   73 EIQKSLDKRKHTQNVALNKKLSDIKTEYL-YELNVLKEKSEAELTSKTKKELDAAF---EQFKKDTLEPGKKVAEATKKV 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  804 SELKKKCGEDQEKIHALTSENTnlkkmmsnqyvpVKTHEEVKMTLNDTLAKTNRELLDVKKKF----EDINQEFVKIKDK 879
Cdd:NF033838  149 EEAEKKAKDQKEEDRRNYPTNT------------YKTLELEIAESDVEVKKAELELVKEEAKEprdeEKIKQAKAKVESK 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  880 NEILKRnLENTQNQIKAeyislAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKV 959
Cdd:NF033838  217 KAEATR-LEKIKTDREK-----AEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSV 290

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  960 --------KYAPIVSFEECERKFKATEKELKDQLSEQTQKY----------SVSEEEVKKNKQENDKLKKEiftlQKDLR 1021
Cdd:NF033838  291 geetlpspSLKPEKKVAEAEKKVEEAKKKAKDQKEEDRRNYptntyktlelEIAESDVKVKEAELELVKEE----AKEPR 366

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1022 DKTVLIEKSHEMERALSRKT------DELNKQLKDLSQKYTEVKNVKEKLVEEnaKQTSEILAVQNLLQKQHVPLEQVEA 1095
Cdd:NF033838  367 NEEKIKQAKAKVESKKAEATrlekikTDRKKAEEEAKRKAAEEDKVKEKPAEQ--PQPAPAPQPEKPAPKPEKPAEQPKA 444


                  ..
gi 530406156 1096 LK 1097
Cdd:NF033838  445 EK 446
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 415-896 5.41e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 47.79  E-value: 5.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   415 NEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQL-------EDALKDVQKRMYESEG 487
Cdd:pfam05483  189 NNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLliqitekENKMKDLTFLLEESRD 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   488 KVKQMQ----------THFLALKEHLTSE----------AASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNE 547
Cdd:pfam05483  269 KANQLEektklqdenlKELIEKKDHLTKEledikmslqrSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHS 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   548 MIVEEFKRDEGKLIE----ENKRLQK---ELSMCEMEREKKGRKVTEMEG--QAKELSAKLALSIPAEKfenmkSSLSNE 618
Cdd:pfam05483  349 FVVTEFEATTCSLEEllrtEQQRLEKnedQLKIITMELQKKSSELEEMTKfkNNKEVELEELKKILAED-----EKLLDE 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   619 vNEKAKKLVEMEREHEKSLSEIRQLK-RELENVKAKLAQHVKPEEHeqvksrLEQKSGELGKKITELTLKNQTLQKEIEK 697
Cdd:pfam05483  424 -KKQFEKIAEELKGKEQELIFLLQAReKEIHDLEIQLTAIKTSEEH------YLKEVEDLKTELEKEKLKNIELTAHCDK 496

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   698 VYLDNKLLKEQAHNLTIEMKNHYVPLKvseDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLET 777
Cdd:pfam05483  497 LLLENKELTQEASDMTLELKKHQEDII---NCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEE 573

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   778 vfvPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEevkmtlnDTLAKTNR 857
Cdd:pfam05483  574 ---NARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYE-------IKVNKLEL 643

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 530406156   858 ELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA 896
Cdd:pfam05483  644 ELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKA 682
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1159-1385 5.94e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.70  E-value: 5.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1159 IKASLREKEEESQNKM----EEVSKLQSEVQNTKQALKKLETRE-VVDLSkykATKSDLETQISSLNEKLANLNRKYEEV 1233
Cdd:COG3206   162 LEQNLELRREEARKALefleEQLPELRKELEEAEAALEEFRQKNgLVDLS---EEAKLLLQQLSELESQLAEARAELAEA 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1234 ceEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNG 1313
Cdd:COG3206   239 --EARLAALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRILA 316

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530406156 1314 LSQLTYTSGNPTKRQ-SQLIDTLQHQVKSL---EQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQ 1385
Cdd:COG3206   317 SLEAELEALQAREASlQAQLAQLEARLAELpelEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGNVRVID 392
Ank_5 pfam13857
Ankyrin repeats (many copies);
40-95 7.62e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 7.62e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 530406156    40 ILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLA 95
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
46 PHA02562
endonuclease subunit; Provisional
 465-675 8.19e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 46.93  E-value: 8.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  465 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASgNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIK 544
Cdd:PHA02562  187 DMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKT-IKAEIEELTDELLNLVMDIEDPSAALNKLNTAAA 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  545 QNEMIVEEFKRDE-----------------------GKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKlal 601
Cdd:PHA02562  266 KIKSKIEQFQKVIkmyekggvcptctqqisegpdriTKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLEL--- 342

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530406156  602 sipAEKFENMKSSLSNEVNEKAKKLVEMER---EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG 675
Cdd:PHA02562  343 ---KNKISTNKQSLITLVDKAKKVKAAIEElqaEFVDNAEELAKLQDELDKIVKTKSELVKEKYHRGIVTDLLKDSG 416
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 556-1267 1.02e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.97  E-value: 1.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   556 DEGKLIEENKRLQKELSMCE-MEREKKGRKVTEMEGQAKELSaklalSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHE 634
Cdd:TIGR01612  694 DKAKLDDLKSKIDKEYDKIQnMETATVELHLSNIENKKNELL-----DIIVEIKKHIHGEINKDLNKILEDFKNKEKELS 768

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   635 KSLSEIRQLKRELENVKAKLAQhVKPEEHEQ--VKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL 712
Cdd:TIGR01612  769 NKINDYAKEKDELNKYKSKISE-IKNHYNDQinIDNIKDEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNK 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   713 TiemkNHYVPLK--VSEDMKKSHDAIIDDLNRKLLDVTQkytEKKLEMEKLLLENDSLSKDVSrletvfvppekheKEII 790
Cdd:TIGR01612  848 V----DKFINFEnnCKEKIDSEHEQFAELTNKIKAEISD---DKLNDYEKKFNDSKSLINEIN-------------KSIE 907

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   791 ALKSNIVELKKqLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLND----TLAKTNRELLDVKKK- 865
Cdd:TIGR01612  908 EEYQNINTLKK-VDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIKESNLIEKSYKDkfdnTLIDKINELDKAFKDa 986

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   866 ----FEDINQEFVK-IKDKNEILKRNLENTQnqikaeYISLAEHEAKMSSLSQsmrKVQDSNAEI----LANYRKGQEEI 936
Cdd:TIGR01612  987 slndYEAKNNELIKyFNDLKANLGKNKENML------YHQFDEKEKATNDIEQ---KIEDANKNIpnieIAIHTSIYNII 1057

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   937 VTLHAEIKAQKKELDTiqECIKVKYAPIVSFEECERKFK---------------ATE-KELKDQLSEQTQK--YSVSEEE 998
Cdd:TIGR01612 1058 DEIEKEIGKNIELLNK--EILEEAEINITNFNEIKEKLKhynfddfgkeenikyADEiNKIKDDIKNLDQKidHHIKALE 1135

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   999 VKKNKQEN--DKLKKEIFTLQkDLRDKTVLIEKSHEMERALSRKTDELNKQlkdlSQKYTEVKNVKEKLVEENAKQTS-E 1075
Cdd:TIGR01612 1136 EIKKKSENyiDEIKAQINDLE-DVADKAISNDDPEEIEKKIENIVTKIDKK----KNIYDEIKKLLNEIAEIEKDKTSlE 1210

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1076 ILAVQNLLQKQHVP---LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLE------------------- 1133
Cdd:TIGR01612 1211 EVKGINLSYGKNLGklfLEKIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMDikaemetfnishdddkdhh 1290

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1134 -----NQKNSSVPLAEHLQIKEAFEKEVGI--IKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDlsKYK 1206
Cdd:TIGR01612 1291 iiskkHDENISDIREKSLKIIEDFSEESDIndIKKELQKNLLDAQKHNSDINLYLNEIANIYNILKLNKIKKIID--EVK 1368

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530406156  1207 ATKSDLETQISSLNEKLANLNRKYEEVCEEVlhaKKKEISAKDEKELLHFSIEQEIKDQKE 1267
Cdd:TIGR01612 1369 EYTKEIEENNKNIKDELDKSEKLIKKIKDDI---NLEECKSKIESTLDDKDIDECIKKIKE 1426
Ank_5 pfam13857
Ankyrin repeats (many copies);
173-220 1.08e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 1.08e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 530406156   173 LIDRG-ADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALG 220
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEG 49
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 923-1385 1.13e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 46.89  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   923 AEILANYrKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERK--------FKATEKELKDQLSE--QTQKY 992
Cdd:TIGR00618  166 KELLMNL-FPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDtyherkqvLEKELKHLREALQQtqQSHAY 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   993 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEmERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQ 1072
Cdd:TIGR00618  245 LTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQE-RINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSR 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1073 TSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQT-----VTKLHQLLENQKNSSVPLAEHLQ 1147
Cdd:TIGR00618  324 AKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHtltqhIHTLQQQKTTLTQKLQSLCKELD 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1148 IKEAFEKEVGIIKASLR---------EKEEESQNKMEEVSKLQSEVQNTKQALKKLE-------TREVVDLSKYKATKSD 1211
Cdd:TIGR00618  404 ILQREQATIDTRTSAFRdlqgqlahaKKQQELQQRYAELCAAAITCTAQCEKLEKIHlqesaqsLKEREQQLQTKEQIHL 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1212 LETQISSLNEKLANLNRKYE-EVCEEVLH--AKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAK 1288
Cdd:TIGR00618  484 QETRKKAVVLARLLELQEEPcPLCGSCIHpnPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKE 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1289 QIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTL---------QHQVKSLEQQLADADRQHQEVIAI 1359
Cdd:TIGR00618  564 QMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLaceqhallrKLQPEQDLQDVRLHLQQCSQELAL 643

                          490       500
                   ....*....|....*....|....*.
gi 530406156  1360 YRTHLLSAAQGHMDEDVQEALLQIIQ 1385
Cdd:TIGR00618  644 KLTALHALQLTLTQERVREHALSIRV 669
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 883-1134 1.22e-04

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 46.69  E-value: 1.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   883 LKRNLENtqnQIKAEYISLAEHEAKMSSLSQSMRKVqdsnAEILANYRKGQEEIVTL--HAEIKAQKKELdtiqecikvk 960
Cdd:pfam18971  557 VRRNLEN---KLTAKGLSLQEANKLIKDFLSSNKEL----AGKALNFNKAVAEAKSTgnYDEVKKAQKDL---------- 619

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   961 yapivsfEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQendklKKEIFTL--QKDLRDKTVL--IEKSHEMERA 1036
Cdd:pfam18971  620 -------EKSLRKREHLEKEVEKKLESKSGNKNKMEAKAQANSQ-----KDEIFALinKEANRDARAIayTQNLKGIKRE 687

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1037 LSRKTDELNKQLKDLSQKYTEVKNVKEKlveENAKQTSEILAVQNLLQKQHVPLEQVEalkkslngTIENLKEELKSMQR 1116
Cdd:pfam18971  688 LSDKLEKISKDLKDFSKSFDEFKNGKNK---DFSKAEETLKALKGSVKDLGINPEWIS--------KVENLNAALNEFKN 756

                          250
                   ....*....|....*...
gi 530406156  1117 CYEKEQQTVTKLHQLLEN 1134
Cdd:pfam18971  757 GKNKDFSKVTQAKSDLEN 774
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 93-173 1.58e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   93 HLAAKyGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQL 172
Cdd:PTZ00322   88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                  .
gi 530406156  173 L 173
Cdd:PTZ00322  167 L 167
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
1187-1311 1.97e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 46.00  E-value: 1.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1187 TKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLnRKYEEVCEEVLHAKKKEIsAKDEKELLHFSIEQEIKDQK 1266
Cdd:COG2433   386 IEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERL-EAEVEELEAELEEKDERI-ERLERELSEARSEERREIRK 463

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 530406156 1267 ERcdksltTITELQRRIQESAKQIEAKDNKITELLNDVERLKQAL 1311
Cdd:COG2433   464 DR------EISRLDREIERLERELEEERERIEELKRKLERLKELW 502
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 171-239 2.01e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.66  E-value: 2.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530406156  171 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL 239
Cdd:PTZ00322   99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 153-185 2.02e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 2.02e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 530406156   153 DGRTPLVLA-TQMSRPTICQLLIDRGADVNSRDK 185
Cdd:pfam00023    1 DGNTPLHLAaGRRGNLEIVKLLLSKGADVNARDK 34
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 838-1348 2.03e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 45.94  E-value: 2.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   838 VKTHEEVKMTLNDTLAKTNRElldvKKKFEDINQEFVKIKDKNEILKRNLENTQNQikaeyislaeHEAKMSSLSQSMRK 917
Cdd:pfam01576  133 IKKLEEDILLLEDQNSKLSKE----RKLLEERISEFTSNLAEEEEKAKSLSKLKNK----------HEAMISDLEERLKK 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   918 VQDSNAEILANYRKGQEEIVTLHAEIKAQKKELdtiqecikvkyapivsfEECERKFKATEKELKDQLSEQTQKYSVSEE 997
Cdd:pfam01576  199 EEKGRQELEKAKRKLEGESTDLQEQIAELQAQI-----------------AELRAQLAKKEEELQAALARLEEETAQKNN 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   998 EVKKNKQendkLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL-----------SQKYTEVKNVKEKLV 1066
Cdd:pfam01576  262 ALKKIRE----LEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTldttaaqqelrSKREQEVTELKKALE 337

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1067 EENAKQTSEilaVQNLLQKQHVPLEQ--------------VEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLH-QL 1131
Cdd:pfam01576  338 EETRSHEAQ---LQEMRQKHTQALEElteqleqakrnkanLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEgQL 414

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1132 LENQKNSSVPLAEHLQIKEAFEK---EVGIIKASLREKEEESQNKMEEVSKLQSEVQNTkQALKKLETREvvdlskykat 1208
Cdd:pfam01576  415 QELQARLSESERQRAELAEKLSKlqsELESVSSLLNEAEGKNIKLSKDVSSLESQLQDT-QELLQEETRQ---------- 483

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1209 KSDLETQISSLNEKLANLNRKYEEvceevlhakkkEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAK 1288
Cdd:pfam01576  484 KLNLSTRLRQLEDERNSLQEQLEE-----------EEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQR 552

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1289 QIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLAD 1348
Cdd:pfam01576  553 ELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAE 612
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 966-1315 2.07e-04

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 45.79  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   966 SFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEndklkkeifTLQKDLRDK-TVLIEKSHEMERALSRKTDEL 1044
Cdd:pfam05667  207 SLLERNAAELAAAQEWEEEWNSQGLASRLTPEEYRKRKRT---------KLLKRIAEQlRSAALAGTEATSGASRSAQDL 277

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1045 NKQLKDLSQKYTEVKNV--------KEKLV--EENAKQTSEILAV----QNLLQKQHVPLEQVEALKKSLNGTIENLKEE 1110
Cdd:pfam05667  278 AELLSSFSGSSTTDTGLtkgsrfthTEKLQftNEAPAATSSPPTKveteEELQQQREEELEELQEQLEDLESSIQELEKE 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1111 LKSMQrcyekeqQTVTKLHQLLENQKNSSVPLAEHLQIKEafeKEVGIIkaslrekeEESQNKMEevsKLQSEVQNTKQA 1190
Cdd:pfam05667  358 IKKLE-------SSIKQVEEELEELKEQNEELEKQYKVKK---KTLDLL--------PDAEENIA---KLQALVDASAQR 416

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1191 LKKLEtrevvdlSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEV--LHAKKKEISAK-DEKELLHfsieQEIKDQKE 1267
Cdd:pfam05667  417 LVELA-------GQWEKHRVPLIEEYRALKEAKSNKEDESQRKLEEIkeLREKIKEVAEEaKQKEELY----KQLVAEYE 485

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 530406156  1268 RCDKSlTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1315
Cdd:pfam05667  486 RLPKD-VSRSAYTRRILEIVKNIKKQKEEITKILSDTKSLQKEINSLT 532
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1046-1226 2.17e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.53  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1046 KQLKDLSQKYTE---VKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSmqrcYEKEQ 1122
Cdd:COG1579     7 RALLDLQELDSEldrLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKK----YEEQL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1123 QTVTKLHQLlenqknssvplaehlqikEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDL 1202
Cdd:COG1579    83 GNVRNNKEY------------------EALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKK 144

                         170       180
                  ....*....|....*....|....
gi 530406156 1203 SKYKATKSDLETQISSLNEKLANL 1226
Cdd:COG1579   145 AELDEELAELEAELEELEAEREEL 168
Ank_4 pfam13637
Ankyrin repeats (many copies);
88-140 2.22e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 2.22e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 530406156    88 GRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLL 140
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 802-1307 2.34e-04

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 45.98  E-value: 2.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  802 QLSELKKKCGEDQEKIHALTSENTNLKKMMSNqyVPVKTHEEVkMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNE 881
Cdd:PTZ00440  985 KLDKEKDEWEHFKSEIDKLNVNYNILNKKIDD--LIKKQHDDI-IELIDKLIKEKGKEIEEKVDQYISLLEKMKTKLSSF 1061

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  882 ILKRNLENTQNQIKAEYISLAEHeaKMSSLsqsMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQ-------KKELDTIQ 954
Cdd:PTZ00440 1062 HFNIDIKKYKNPKIKEEIKLLEE--KVEAL---LKKIDENKNKLIEIKNKSHEHVVNADKEKNKQtehynkkKKSLEKIY 1136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  955 ECIKVKYAPIVSFEECERKFKATEK-----------ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDlrdk 1023
Cdd:PTZ00440 1137 KQMEKTLKELENMNLEDITLNEVNEieieyerilidHIVEQINNEAKKSKTIMEEIESYKKDIDQVKKNMSKERND---- 1212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1024 tvlieksHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKlvEENAKQTSEILAVQNLLqkqHVPLEQVealkKSLNGT 1103
Cdd:PTZ00440 1213 -------HLTTFEYNAYYDKATASYENIEELTTEAKGLKGE--ANRSTNVDELKEIKLQV---FSYLQQV----IKENNK 1276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1104 IENLKEELKSMqrcyeKEQQTVTKLHQLLENQKNSSVPLAEH-LQIKEAFEKEVGIIKASLR--EKEEESQNKM---EEV 1177
Cdd:PTZ00440 1277 MENALHEIKNM-----YEFLISIDSEKILKEILNSTKKAEEFsNDAKKELEKTDNLIKQVEAkiEQAKEHKNKIygsLED 1351

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1178 SKLQSEVQNTKQALKKL-ETREVVD--LSKYKATKSDLETQISSLNEKLANLNrkyeevceevLHAKKKEISAKDEKEll 1254
Cdd:PTZ00440 1352 KQIDDEIKKIEQIKEEIsNKRKEINkyLSNIKSNKEKCDLHVRNASRGKDKID----------FLNKHEAIEPSNSKE-- 1419

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 530406156 1255 hFSIeQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERL 1307
Cdd:PTZ00440 1420 -VNI-IKITDNINKCKQYSNEAMETENKADENNDSIIKYEKEITNILNNSSIL 1470
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 967-1330 2.61e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 45.73  E-value: 2.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   967 FEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNK 1046
Cdd:pfam02463  165 SRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQE 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1047 QLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT 1126
Cdd:pfam02463  245 LLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKK 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1127 KLHQLLENQKNSSVPLaehlqikEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYK 1206
Cdd:pfam02463  325 KAEKELKKEKEEIEEL-------EKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEEL 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1207 ATKSDLETQISSLNEklanlNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQES 1286
Cdd:pfam02463  398 ELKSEEEKEAQLLLE-----LARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSED 472

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 530406156  1287 AKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQ 1330
Cdd:pfam02463  473 LLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALI 516
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
471-672 2.69e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 45.53  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  471 LEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE------ELKDQLKDLKVKYEGASAEVGKLRnQIK 544
Cdd:COG4717    47 LLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAElqeeleELEEELEELEAELEELREELEKLE-KLL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  545 QNEMIVEEFKRDEGKLIEENKRLQkELSMCEMEREKKGRKVTEMEGQAKELSAKLAlsipaEKFENMKSSLSNEVNEKAK 624
Cdd:COG4717   126 QLLPLYQELEALEAELAELPERLE-ELEERLEELRELEEELEELEAELAELQEELE-----ELLEQLSLATEEELQDLAE 199

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 530406156  625 KLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQ 672
Cdd:COG4717   200 ELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKE 247
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 123-247 2.74e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 2.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  123 TALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGAD----------------------- 179
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipciekdmiktildcgid 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  180 VNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLL--KTASENTN 247
Cdd:PHA02874  117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLleKGAYANVK 186
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
465-642 2.84e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.68  E-value: 2.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  465 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTE----ELKDQLKDLkvkyEGASAEVGKLR 540
Cdd:COG4913   616 EAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEreiaELEAELERL----DASSDDLAALE 691

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  541 NQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAK-----ELSAKLALSIPAEKFENMKSSL 615
Cdd:COG4913   692 EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARlelraLLEERFAAALGDAVERELRENL 771

                         170       180
                  ....*....|....*....|....*..
gi 530406156  616 SNEVNEKAKKLVEMEREHEKSLSEIRQ 642
Cdd:COG4913   772 EERIDALRARLNRAEEELERAMRAFNR 798
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1035-1296 2.99e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.75  E-value: 2.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1035 RALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSM 1114
Cdd:COG4942    23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1115 QRCYEKeqqtvtklhQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKAsLREKEEESQNKMEEVSKLQSEVQNTKQALKkl 1194
Cdd:COG4942   103 KEELAE---------LLRALYRLGRQPPLALLLSPEDFLDAVRRLQY-LKYLAPARREQAEELRADLAELAALRAELE-- 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1195 etrevvdlskykATKSDLETQISSLNEKLANLNrkyeevceevlhakkkeiSAKDEKELLHFSIEQEIKDQKERCDKSLT 1274
Cdd:COG4942   171 ------------AERAELEALLAELEEERAALE------------------ALKAERQKLLARLEKELAELAAELAELQQ 220

                         250       260
                  ....*....|....*....|..
gi 530406156 1275 TITELQRRIQESAKQIEAKDNK 1296
Cdd:COG4942   221 EAEELEALIARLEAEAAAAAER 242
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1026-1314 3.07e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.44  E-value: 3.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1026 LIEKSHEMERALSRKT--DELNKQLKDLSQKYTEVKNVKEKLvEENAKQTSEIlavQNLLQKQHVPLEQVEALKKSLNGT 1103
Cdd:PRK03918  140 ILESDESREKVVRQILglDDYENAYKNLGEVIKEIKRRIERL-EKFIKRTENI---EELIKEKEKELEEVLREINEISSE 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1104 IENLKEELKSMqrcyEKEQQTVTKLHQLLENQKNSsvplaehlqiKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSE 1183
Cdd:PRK03918  216 LPELREELEKL----EKEVKELEELKEEIEELEKE----------LESLEGSKRKLEEKIRELEERIEELKKEIEELEEK 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1184 VQNTKQ---------ALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEevLHAKKKEIS---AKDEK 1251
Cdd:PRK03918  282 VKELKElkekaeeyiKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEE--LKKKLKELEkrlEELEE 359

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530406156 1252 ELLHFSIEQEIKDQKERCDKSLT--TITELQRRIQESAK---QIEAKDNKIT----ELLNDVERLKQALNGL 1314
Cdd:PRK03918  360 RHELYEEAKAKKEELERLKKRLTglTPEKLEKELEELEKakeEIEEEISKITarigELKKEIKELKKAIEEL 431
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1157-1388 3.16e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.31  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1157 GIIKasLREKEEESQNKMEEVS-------------------------------KLQSEVQNTKQALKKLETREV-VDLSK 1204
Cdd:COG1196   166 GISK--YKERKEEAERKLEATEenlerledilgelerqleplerqaekaeryrELKEELKELEAELLLLKLRELeAELEE 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1205 YKATKSDLETQISSLNEKLANLNRKYEEVcEEVLHAKKKEISAKDEKELLHFS----IEQEIKDQKERCDKSLTTITELQ 1280
Cdd:COG1196   244 LEAELEELEAELEELEAELAELEAELEEL-RLELEELELELEEAQAEEYELLAelarLEQDIARLEERRRELEERLEELE 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1281 RRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQhQEVIAIY 1360
Cdd:COG1196   323 EELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA-AAELAAQ 401

                         250       260
                  ....*....|....*....|....*...
gi 530406156 1361 RTHLLSAAQGHMDEdvQEALLQIIQMRQ 1388
Cdd:COG1196   402 LEELEEAEEALLER--LERLEEELEELE 427
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 25-172 3.22e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 3.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   25 LMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLEcLNAILIHGV------DITTSDTAGRNALHLAAKY 98
Cdd:cd22192    21 LLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLE-AAVVLMEAApelvnePMTSDLYQGETALHIAVVN 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   99 GHALCLQKLLQYNcptehADLQ-----------GRTAL-----HDAAMADCPSS---IQLLCDHGASVNAKDVDGRTPL- 158
Cdd:cd22192   100 QNLNLVRELIARG-----ADVVspratgtffrpGPKNLiyygeHPLSFAACVGNeeiVRLLIEHGADIRAQDSLGNTVLh 174

                         170
                  ....*....|....
gi 530406156  159 VLATQMSRPTICQL 172
Cdd:cd22192   175 ILVLQPNKTFACQM 188
Ank_5 pfam13857
Ankyrin repeats (many copies);
107-161 3.30e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.02  E-value: 3.30e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 530406156   107 LLQY-NCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLA 161
Cdd:pfam13857    1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 975-1190 3.73e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.44  E-value: 3.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  975 KATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRdktvliekshEMERALSRKTDELNKQLKDLSQK 1054
Cdd:COG3883    29 QAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIA----------EAEAEIEERREELGERARALYRS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1055 YTEVkNVKEKLVeeNAKQTSEIL----AVQNLLQKQHVPLEQVEALKKSLngtiENLKEELKSMQRCYEKEQQTVTKLHQ 1130
Cdd:COG3883    99 GGSV-SYLDVLL--GSESFSDFLdrlsALSKIADADADLLEELKADKAEL----EAKKAELEAKLAELEALKAELEAAKA 171

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1131 LLENQKnssvplAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQA 1190
Cdd:COG3883   172 ELEAQQ------AEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAA 225
PRK11281 PRK11281
mechanosensitive channel MscK;
737-1100 3.94e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.90  E-value: 3.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  737 IDDLN-RKLLDVTQKYTEKKLEMEKLLLENdslskdvsrletvfvppekhekeIIALKSNIVELKKQLSELKKKCGEDQE 815
Cdd:PRK11281   45 LDALNkQKLLEAEDKLVQQDLEQTLALLDK-----------------------IDRQKEETEQLKQQLAQAPAKLRQAQA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  816 KIHALTSENTN-LKKMMSNQYVPvktheevkmTLNDTLAKTNRELLDVKKKFEDINQEFVKikdkneiLKRNLENTQNQI 894
Cdd:PRK11281  102 ELEALKDDNDEeTRETLSTLSLR---------QLESRLAQTLDQLQNAQNDLAEYNSQLVS-------LQTQPERAQAAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  895 KAEYISLAEHEAKMSSLSQSMRKVQDSNAEILanyrkgQEEIVTLHAEIKAQKKEL---DTIQECIKVKYapivsfEECE 971
Cdd:PRK11281  166 YANSQRLQQIRNLLKGGKVGGKALRPSQRVLL------QAEQALLNAQNDLQRKSLegnTQLQDLLQKQR------DYLT 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  972 RKFKATEKELKD----------QLSEQTQKYSVSEEEVKKnKQENDKLKKEiftlqkdlrdktvlIEKSHEMERALSRKT 1041
Cdd:PRK11281  234 ARIQRLEHQLQLlqeainskrlTLSEKTVQEAQSQDEAAR-IQANPLVAQE--------------LEINLQLSQRLLKAT 298

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530406156 1042 DELNkqlkDLSQKYTEVKNVKEklveenakqtseilavqNLLQKQHVPLEQVEALKKSL 1100
Cdd:PRK11281  299 EKLN----TLTQQNLRVKNWLD-----------------RLTQSERNIKEQISVLKGSL 336
PHA02798 PHA02798
ankyrin-like protein; Provisional
 137-214 4.24e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 44.44  E-value: 4.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  137 IQLLCDHGASVNAKDVDGRTPLVlaTQMSRPTICQL-----LIDRGADVNSRDKQNRTALMLGCEYGCR---DAVEVLIK 208
Cdd:PHA02798   92 VKILIENGADINKKNSDGETPLY--CLLSNGYINNLeillfMIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLE 169


                  ....*.
gi 530406156  209 NGADIS 214
Cdd:PHA02798  170 KGVDIN 175
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 553-817 4.39e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 44.53  E-value: 4.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  553 FKRDEGKLIEEnkrLQKE-----LSMCEMEREKKGRKVTEMEGQAKELSAKL------ALSIPAEKFENMKSSLSNEVNE 621
Cdd:PRK05771   14 LKSYKDEVLEA---LHELgvvhiEDLKEELSNERLRKLRSLLTKLSEALDKLrsylpkLNPLREEKKKVSVKSLEELIKD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  622 KAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQhVKP-------EEHEQVKSRLEQKSGELGKKITELTLKNQTLQKE 694
Cdd:PRK05771   91 VEEELEKIEKEIKELEEEISELENEIKELEQEIER-LEPwgnfdldLSLLLGFKYVSVFVGTVPEDKLEELKLESDVENV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  695 IEKVYLDNKL------LKEQAHNLTIEMKNH-YVPLKVSE------------DMKKSHDAIIDDLNRKLLDVTQKYTEKK 755
Cdd:PRK05771  170 EYISTDKGYVyvvvvvLKELSDEVEEELKKLgFERLELEEegtpselireikEELEEIEKERESLLEELKELAKKYLEEL 249

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530406156  756 LEMEKLLL----ENDSLSKDVSRLETVFVP---PEKHEKEIIALKSNIVELKKQLSELKKKcgEDQEKI 817
Cdd:PRK05771  250 LALYEYLEieleRAEALSKFLKTDKTFAIEgwvPEDRVKKLKELIDKATGGSAYVEFVEPD--EEEEEV 316
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 971-1137 4.62e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 44.53  E-value: 4.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  971 ERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT--------- 1041
Cdd:PRK05771   74 EEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERLEPWGNFDLDLSLLLGFKYvsvfvgtvp 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1042 -DELNKQLKDLSQKYTE-VKNVKEKLV------EENAKQTSEILAvQNLLQKQHVP--------LEQVEALKKSLNGTIE 1105
Cdd:PRK05771  154 eDKLEELKLESDVENVEyISTDKGYVYvvvvvlKELSDEVEEELK-KLGFERLELEeegtpselIREIKEELEEIEKERE 232

                         170       180       190
                  ....*....|....*....|....*....|..
gi 530406156 1106 NLKEELKSMQRCYEKEQQTVtklHQLLENQKN 1137
Cdd:PRK05771  233 SLLEELKELAKKYLEELLAL---YEYLEIELE 261
46 PHA02562
endonuclease subunit; Provisional
 584-809 4.88e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.62  E-value: 4.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  584 KVTEMEGQAKELSAKLALSIPA----EKFENMKSSLSNEVNEKAKKLVEMEREhekslsEIRQLKRELENVKAKLAQHVK 659
Cdd:PHA02562  175 KIRELNQQIQTLDMKIDHIQQQiktyNKNIEEQRKKNGENIARKQNKYDELVE------EAKTIKAEIEELTDELLNLVM 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  660 PEEheqvksRLEQKSGELGKKITELTLKNQTLQKEIeKVYLDNKL-----------------LKEQAHNLTI---EMKNH 719
Cdd:PHA02562  249 DIE------DPSAALNKLNTAAAKIKSKIEQFQKVI-KMYEKGGVcptctqqisegpdritkIKDKLKELQHsleKLDTA 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  720 YVPLKVSEDMkkshdaiIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVppeKHEKEIIALKSNIVEL 799
Cdd:PHA02562  322 IDELEEIMDE-------FNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFV---DNAEELAKLQDELDKI 391

                         250
                  ....*....|
gi 530406156  800 KKQLSELKKK 809
Cdd:PHA02562  392 VKTKSELVKE 401
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 120-151 5.24e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 5.24e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530406156   120 QGRTALHDAA-MADCPSSIQLLCDHGASVNAKD 151
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 503-712 5.39e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 5.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  503 LTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG 582
Cdd:COG4942    10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  583 RKVTEMEGQAKELSAKLALSIPA----EKFENMKSSLSNEVNEKAKKLVEM----EREHEKSLSEIRQLKRELENVKAKL 654
Cdd:COG4942    90 KEIAELRAELEAQKEELAELLRAlyrlGRQPPLALLLSPEDFLDAVRRLQYlkylAPARREQAEELRADLAELAALRAEL 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 530406156  655 AQhvKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNL 712
Cdd:COG4942   170 EA--ERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEEL 225
PLN02939 PLN02939
transferase, transferring glycosyl groups
 238-579 5.40e-04

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 44.51  E-value: 5.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  238 LLKTASENTNKGRELWKKGPSLQQRNlTHMQDEVNVKSHQR-EHQNIQDLEIEN-------------EDL---------- 293
Cdd:PLN02939   65 LQSNTDENGQLENTSLRTVMELPQKS-TSSDDDHNRASMQRdEAIAAIDNEQQTnskdgeqlsdfqlEDLvgmiqnaekn 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  294 -----KERLRKIQQEQRILLDK------VNGLQLQLNEREKlKSLLAAKEKQHEESLRtiEALKNRFKYFESDHLGSGSH 362
Cdd:PLN02939  144 illlnQARLQALEDLEKILTEKealqgkINILEMRLSETDA-RIKLAAQEKIHVEILE--EQLEKLRNELLIRGATEGLC 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  363 FSN--------RKEDMLLKQGQMYM----ADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKkeLEAMRTFCE 430
Cdd:PLN02939  221 VHSlskeldvlKEENMLLKDDIQFLkaelIEVAETEERVFKLEKERSLLDASLRELESKFIVAQEDVSK--LSPLQYDCW 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  431 SAKQDRLKLQNELAHKVAECKALALECERvkeDSDEQIKQLEDALKdvqkrmyesEGKVKQMQTHFLALkehltseaasg 510
Cdd:PLN02939  299 WEKVENLQDLLDRATNQVEKAALVLDQNQ---DLRDKVDKLEASLK---------EANVSKFSSYKVEL----------- 355

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530406156  511 nhrlteeLKDQLKDLKVKYEGASAEVgklRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMERE 579
Cdd:PLN02939  356 -------LQQKLKLLEERLQASDHEI---HSYIQLYQESIKEFQDTLSKLKEESKKRSLEHPADDMPSE 414
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1104-1315 6.07e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 44.15  E-value: 6.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1104 IENLKEELKSMQ-RCYEKEQQTVTKLHQLLENQKNssvplAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQS 1182
Cdd:PRK05771   33 IEDLKEELSNERlRKLRSLLTKLSEALDKLRSYLP-----KLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKELEE 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1183 EVQNTKQALKKLEtREVVDLSKYKATKSDLETQISSLN----------EKLANLNRKYEEVCEEVLHAKK---------- 1242
Cdd:PRK05771  108 EISELENEIKELE-QEIERLEPWGNFDLDLSLLLGFKYvsvfvgtvpeDKLEELKLESDVENVEYISTDKgyvyvvvvvl 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1243 KEISAKDEKELLHFS-IEQEIKDQK---ERCDKSLTTITELQRRIQESAKQIEAKDNKITE--------LLNDVERLKQA 1310
Cdd:PRK05771  187 KELSDEVEEELKKLGfERLELEEEGtpsELIREIKEELEEIEKERESLLEELKELAKKYLEellalyeyLEIELERAEAL 266


                  ....*
gi 530406156 1311 LNGLS 1315
Cdd:PRK05771  267 SKFLK 271
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 1004-1289 6.91e-04

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 44.38  E-value: 6.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1004 QENDKLKKEIFTLQKDLRDKTVLIEKS-----------------HEMERALsRKTDELNKQLKDLSQKYTEVKNVKEKLV 1066
Cdd:pfam18971  573 QEANKLIKDFLSSNKELAGKALNFNKAvaeakstgnydevkkaqKDLEKSL-RKREHLEKEVEKKLESKSGNKNKMEAKA 651

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1067 EENAkQTSEILAVQNLLQKQHVP----LEQVEALKKSLNGTIENLKEELKSMQRCYEKeqqtvtklhqlLENQKNSSVPL 1142
Cdd:pfam18971  652 QANS-QKDEIFALINKEANRDARaiayTQNLKGIKRELSDKLEKISKDLKDFSKSFDE-----------FKNGKNKDFSK 719

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1143 AEH-LQIKEAFEKEVGIikaslrekeeesqnKMEEVSKlqseVQNTKQALKKLETREVVDLSKYKATKSDLETQISS--L 1219
Cdd:pfam18971  720 AEEtLKALKGSVKDLGI--------------NPEWISK----VENLNAALNEFKNGKNKDFSKVTQAKSDLENSVKDviI 781

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530406156  1220 NEKLANlnrKYEEVCEEVLHAKKKEISAKDEK---ELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQ 1289
Cdd:pfam18971  782 NQKVTD---KVDNLNQAVSVAKAMGDFSRVEQvlaDLKNFSKEQLAQQAQKNEDFNTGKNSELYQSVKNSVNK 851
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1168-1312 7.25e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.99  E-value: 7.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1168 EESQNKMEEVSKLQSEVQNTKQALKKLEtREVVDLSK----YKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKK 1243
Cdd:COG1579     3 PEDLRALLDLQELDSELDRLEHRLKELP-AELAELEDelaaLEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530406156 1244 EISAKDEKELLhfSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALN 1312
Cdd:COG1579    82 LGNVRNNKEYE--ALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELD 148
PTZ00121 PTZ00121
MAEBL; Provisional
 904-1293 7.56e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 7.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  904 HEAKMSSLSQ--SMRKVQDSNAEILANYRKGQEEIVTLHAEIK----AQKKELDTIQECIKVKYApiVSFEECERKFKAT 977
Cdd:PTZ00121 1056 HEGKAEAKAHvgQDEGLKPSYKDFDFDAKEDNRADEATEEAFGkaeeAKKTETGKAEEARKAEEA--KKKAEDARKAEEA 1133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  978 EKELKDQLSEQTQKySVSEEEVKKNKQENDKLKKEIFTLQKDLRdKTVLIEKSHEMERALS-RKTDELNKqlKDLSQKYT 1056
Cdd:PTZ00121 1134 RKAEDARKAEEARK-AEDAKRVEIARKAEDARKAEEARKAEDAK-KAEAARKAEEVRKAEElRKAEDARK--AEAARKAE 1209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1057 EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP--LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLEN 1134
Cdd:PTZ00121 1210 EERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAkkAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEK 1289

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1135 QKNSSVPLAEHLQIKEAFEKEVGIIKAS--LREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDL 1212
Cdd:PTZ00121 1290 KKADEAKKAEEKKKADEAKKKAEEAKKAdeAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAA 1369

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1213 ETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEA 1292
Cdd:PTZ00121 1370 EKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA 1449


                  .
gi 530406156 1293 K 1293
Cdd:PTZ00121 1450 K 1450
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1160-1355 7.85e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 7.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1160 KASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLEtrevVDLSKYKATKSDLETQISSLNEKLAnlnRKYEEVCEEVLH 1239
Cdd:COG3883    22 QKELSELQAELEAAQAELDALQAELEELNEEYNELQ----AELEALQAEIDKLQAEIAEAEAEIE---ERREELGERARA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1240 AKKKE---------ISAKDEKELLH--FSIEQEIKDQKERcdksLTTITELQRRIQESAKQIEAKDNKITELLNDVERLK 1308
Cdd:COG3883    95 LYRSGgsvsyldvlLGSESFSDFLDrlSALSKIADADADL----LEELKADKAELEAKKAELEAKLAELEALKAELEAAK 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 530406156 1309 QALNGLsqltytsgnpTKRQSQLIDTLQHQVKSLEQQLADADRQHQE 1355
Cdd:COG3883   171 AELEAQ----------QAEQEALLAQLSAEEAAAEAQLAELEAELAA 207
Ank_2 pfam12796
Ankyrin repeats (3 copies);
16-85 8.42e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.71  E-value: 8.42e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530406156    16 ADWNKYDDR----LMKAAERGDVEKVTSILAKKGVNpgkLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSD 85
Cdd:pfam12796   21 ADANLQDKNgrtaLHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1201-1358 8.78e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 8.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1201 DLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLhakkkeisakdekellhfSIEQEIKDQKERcdkslttITELQ 1280
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYN------------------ELQAELEALQAE-------IDKLQ 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1281 RRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTyTSGNP-------------TKRQSQLIDTLQHQVKSLEQQLA 1347
Cdd:COG3883    72 AEIAEAEAEIEERREELGERARALYRSGGSVSYLDVLL-GSESFsdfldrlsalskiADADADLLEELKADKAELEAKKA 150

                         170
                  ....*....|.
gi 530406156 1348 DADRQHQEVIA 1358
Cdd:COG3883   151 ELEAKLAELEA 161
Ank_5 pfam13857
Ankyrin repeats (many copies);
142-191 8.83e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 8.83e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 530406156   142 DHG-ASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTAL 191
Cdd:pfam13857    3 EHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_5 pfam13857
Ankyrin repeats (many copies);
79-126 9.64e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 9.64e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 530406156    79 VDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALH 126
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
PRK12704 PRK12704
phosphodiesterase; Provisional
 1096-1268 1.01e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.23  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1096 LKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLhQLLENQKnssvplaEHLQIKEAFEKEVGIIKASLREKEEESQNKME 1175
Cdd:PRK12704   25 RKKIAEAKIKEAEEEAKRILEEAKKEAEAIKKE-ALLEAKE-------EIHKLRNEFEKELRERRNELQKLEKRLLQKEE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1176 EVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKL---ANLNRkyEEVCEEVLHAKKKEisAKDEKE 1252
Cdd:PRK12704   97 NLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELeriSGLTA--EEAKEILLEKVEEE--ARHEAA 172

                         170
                  ....*....|....*.
gi 530406156 1253 LLHFSIEQEIKDQKER 1268
Cdd:PRK12704  173 VLIKEIEEEAKEEADK 188
PHA02946 PHA02946
ankyin-like protein; Provisional
 137-214 1.06e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 43.12  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  137 IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTAL--MLGCEYGCRDAVEVLIKNGADIS 214
Cdd:PHA02946   55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKIN 134
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
974-1268 1.39e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.37  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  974 FKATEK--ELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKdlrdktvlIEKSHEME---RALSRKTDELNKQL 1048
Cdd:COG4913   606 FDNRAKlaALEAELAELEEELAEAEERLEALEAELDALQERREALQR--------LAEYSWDEidvASAEREIAELEAEL 677

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1049 KDLSQKYTEVKNVKEKLVEenakqtseilavqnlLQKQhvpLEQVEALKKSLNGTIENLKEELKSMQRcyekEQQTVTkl 1128
Cdd:COG4913   678 ERLDASSDDLAALEEQLEE---------------LEAE---LEELEEELDELKGEIGRLEKELEQAEE----ELDELQ-- 733

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1129 HQLLENQKNSSVPLAEHLQikEAFEkevgiikaslREKEEESQNKMEEvsKLQSEVQNTKQALKKLETReVVDL-----S 1203
Cdd:COG4913   734 DRLEAAEDLARLELRALLE--ERFA----------AALGDAVERELRE--NLEERIDALRARLNRAEEE-LERAmrafnR 798

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530406156 1204 KYKATKSDLETQISSLNEKLAnlnrKYEEVCEEVLHAKKKEI------SAKDEKELLHFSIEQEIKDQKER 1268
Cdd:COG4913   799 EWPAETADLDADLESLPEYLA----LLDRLEEDGLPEYEERFkellneNSIEFVADLLSKLRRAIREIKER 865
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
462-695 1.56e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 43.11  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  462 EDSDEQIKQLEDALKDVQKRMYESEGKVKQMqthflalkehltsEAASgnhrlteELKDQLKDLKVKYEGASAEVGKLRN 541
Cdd:PRK02224  471 EEDRERVEELEAELEDLEEEVEEVEERLERA-------------EDLV-------EAEDRIERLEERREDLEELIAERRE 530

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  542 QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLalsipaEKFENMKSSLS----- 616
Cdd:PRK02224  531 TIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERI------ESLERIRTLLAaiada 604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  617 ----NEVNEKAKKLVEMEREHEKSLSEIRQLKRELEnvkAKLaQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQ 692
Cdd:PRK02224  605 edeiERLREKREALAELNDERRERLAEKRERKRELE---AEF-DEARIEEAREDKERAEEYLEQVEEKLDELREERDDLQ 680


                  ...
gi 530406156  693 KEI 695
Cdd:PRK02224  681 AEI 683
Ank_4 pfam13637
Ankyrin repeats (many copies);
21-71 1.67e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 1.67e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 530406156    21 YDDRLMKAAERGDVEkVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECL 71
Cdd:pfam13637    1 ELTALHAAAASGHLE-LLRLLLEKGADINAVDGNGETALHFAASNGNVEVL 50
COG5022 COG5022
Myosin heavy chain [General function prediction only];
294-772 1.75e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 43.14  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  294 KERLRKIQQEQRILLDKVNGLQLQLNEREkLKSLLAAKEKqheESLRTIEALKNRFKYFESdhlgsgshfSNRKEDMLLK 373
Cdd:COG5022   762 RRYLQALKRIKKIQVIQHGFRLRRLVDYE-LKWRLFIKLQ---PLLSLLGSRKEYRSYLAC---------IIKLQKTIKR 828

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  374 QGQMYMADSQCTSpgipahMQSRSMLRPLELSLPSQTSYSE-------NEILKKELEAMRTFCEsaKQDRLKLQNELAHK 446
Cdd:COG5022   829 EKKLRETEEVEFS------LKAEVLIQKFGRSLKAKKRFSLlkketiyLQSAQRVELAERQLQE--LKIDVKSISSLKLV 900

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  447 VAECKALALECERvKEDSDEQIK-----QLEDALKDVQKRMYESEGKVKQMQTHFLALKEHltseaasgnhrlteELKDQ 521
Cdd:COG5022   901 NLELESEIIELKK-SLSSDLIENlefktELIARLKKLLNNIDLEEGPSIEYVKLPELNKLH--------------EVESK 965

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  522 LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEgQAKELSAKLAL 601
Cdd:COG5022   966 LKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQESTKQLKELPVEVAELQSASK-IISSESTELSI 1044

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  602 SIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR--------ELENVKAKLAQHVKPEEHEQVKSRLEQK 673
Cdd:COG5022  1045 LKPLQKLKGLLLLENNQLQARYKALKLRRENSLLDDKQLYQLEStenllktiNVKDLEVTNRNLVKPANVLQFIVAQMIK 1124

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  674 SGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTE 753
Cdd:COG5022  1125 LNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAALSEKRLYQSALYDEKSKLSSSEVNDLKN 1204

                         490
                  ....*....|....*....
gi 530406156  754 KKLEMEKLLLENDSLSKDV 772
Cdd:COG5022  1205 ELIALFSKIFSGWPRGDKL 1223
PRK12704 PRK12704
phosphodiesterase; Provisional
 971-1121 2.40e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  971 ERKFKATEKELKDQLSE-QTQKYSVSEEEVKKNKQENDKLK-----------KEIFTLQKDLRDKTVLIEKSHEmerALS 1038
Cdd:PRK12704   30 EAKIKEAEEEAKRILEEaKKEAEAIKKEALLEAKEEIHKLRnefekelrerrNELQKLEKRLLQKEENLDRKLE---LLE 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1039 RKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKqhvpleqvEALKKSLNGTIENLKEELKSMQRCY 1118
Cdd:PRK12704  107 KREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLTAE--------EAKEILLEKVEEEARHEAAVLIKEI 178


                  ...
gi 530406156 1119 EKE 1121
Cdd:PRK12704  179 EEE 181
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 516-661 2.41e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  516 EELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEF----KRDEGKLieENKRLQKELSMCEMEREKKGRKVTEMEGQ 591
Cdd:COG1579    34 AELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVeariKKYEEQL--GNVRNNKEYEALQKEIESLKRRISDLEDE 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  592 AKELSAKLalsipaEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPE 661
Cdd:COG1579   112 ILELMERI------EELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKIPPE 175
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 187-214 2.46e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.85  E-value: 2.46e-03
                           10        20
                   ....*....|....*....|....*...
gi 530406156   187 NRTALMLGCEYGCRDAVEVLIKNGADIS 214
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1026-1168 2.51e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.51  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1026 LIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKqtseilavqnLLQKQHVPLEQ-VEALKKSLNGTI 1104
Cdd:PRK00409  521 LIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDK----------LLEEAEKEAQQaIKEAKKEADEII 590

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530406156 1105 ENLkeelksmqRCYEKEQQTVTKLHQLLENQKNssvpLAEHLQIKEAFEKEVGIIKASLREKEE 1168
Cdd:PRK00409  591 KEL--------RQLQKGGYASVKAHELIEARKR----LNKANEKKEKKKKKQKEKQEELKVGDE 642
PRK12704 PRK12704
phosphodiesterase; Provisional
 941-1076 2.92e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 2.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  941 AEIKAQKKELDTIQECIKVKyapivsfEECERKFKATEKELKDQLSEQTQKysvsEEEVKKNKQENDKLKKEIFTLQKDL 1020
Cdd:PRK12704   51 AEAIKKEALLEAKEEIHKLR-------NEFEKELRERRNELQKLEKRLLQK----EENLDRKLELLEKREEELEKKEKEL 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530406156 1021 RDKTVLIEKsheMERALSRKTDELNKQLKDLSQKYTE------VKNVKEKLVEENAKQTSEI 1076
Cdd:PRK12704  120 EQKQQELEK---KEEELEELIEEQLQELERISGLTAEeakeilLEKVEEEARHEAAVLIKEI 178
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 753-1309 2.93e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 42.12  E-value: 2.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   753 EKKLEMEKLLLE---NDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKK----CGEDQEKIHALTSENT 825
Cdd:pfam10174  203 QKEKENIHLREElhrRNQLQPDPAKTKALQTVIEMKDTKISSLERNIRDLEDEVQMLKTNgllhTEDREEEIKQMEVYKS 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   826 NLKKMMSNQyvpvkthEEVKMTLNdtlaKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNL---ENTQNQIKAEYISL- 901
Cdd:pfam10174  283 HSKFMKNKI-------DQLKQELS----KKESELLALQTKLETLTNQNSDCKQHIEVLKESLtakEQRAAILQTEVDALr 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   902 AEHEAKMSSLSQSMRKVQDSnaeilanyrkgQEEIVTLHAEIKAQKKELDtiqecikVKyapivsfeecERKFKATEKE- 980
Cdd:pfam10174  352 LRLEEKESFLNKKTKQLQDL-----------TEEKSTLAGEIRDLKDMLD-------VK----------ERKINVLQKKi 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   981 --LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEK-SHEMERALSRKTDELNKQLKDLsqkyte 1057
Cdd:pfam10174  404 enLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEEALSEKERIIERlKEQREREDRERLEELESLKKEN------ 477

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1058 vKNVKEKLVeenakqtseilAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLhqllENQKN 1137
Cdd:pfam10174  478 -KDLKEKVS-----------ALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKL----ENQLK 541

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1138 SSVPLAEHLQIKEAFEKEVgiikaslREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQIS 1217
Cdd:pfam10174  542 KAHNAEEAVRTNPEINDRI-------RLLEQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELESLTLRQMK 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1218 SLNEKLANLNRKYEEvcEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKI 1297
Cdd:pfam10174  615 EQNKKVANIKHGQQE--MKKKGAQLLEEARRREDNLADNSQQLQLEELMGALEKTRQELDATKARLSSTQQSLAEKDGHL 692

                          570
                   ....*....|..
gi 530406156  1298 TELlnDVERLKQ 1309
Cdd:pfam10174  693 TNL--RAERRKQ 702
mukB PRK04863
chromosome partition protein MukB;
1002-1369 3.16e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 42.25  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1002 NKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYtevknvkeklveenakqtseilavqn 1081
Cdd:PRK04863  277 HANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDY-------------------------- 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1082 llqkqhvpleqvealkkslngtiENLKEELKSMQ---RCYEKEQQTVTKLHQLLENqknssvpLAEHLQIKEafekEVGI 1158
Cdd:PRK04863  331 -----------------------QAASDHLNLVQtalRQQEKIERYQADLEELEER-------LEEQNEVVE----EADE 376

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1159 IKASLREKEEESQnkmEEVSKLQSEVQNTKQALKKLETRE------VVDLSKYKATKSDLETQISSLNEKLANLNRKYEE 1232
Cdd:PRK04863  377 QQEENEARAEAAE---EEVDELKSQLADYQQALDVQQTRAiqyqqaVQALERAKQLCGLPDLTADNAEDWLEEFQAKEQE 453

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1233 VCEEVLHAKKKeisakdekellhFSIEQEIKDQKERCDKSLTTIT-------------ELQRRIQES---AKQIEAKDNK 1296
Cdd:PRK04863  454 ATEELLSLEQK------------LSVAQAAHSQFEQAYQLVRKIAgevsrseawdvarELLRRLREQrhlAEQLQQLRMR 521

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1297 ITEL------LNDVERLKQALNGLSQLTYTS----GNPTKRQSQLIDTLQHQVKSLEQQLADAdRQHQEVIAIYRTHLLS 1366
Cdd:PRK04863  522 LSELeqrlrqQQRAERLLAEFCKRLGKNLDDedelEQLQEELEARLESLSESVSEARERRMAL-RQQLEQLQARIQRLAA 600


                  ...
gi 530406156 1367 AAQ 1369
Cdd:PRK04863  601 RAP 603
Ank_4 pfam13637
Ankyrin repeats (many copies);
154-207 3.33e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 3.33e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 530406156   154 GRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLI 207
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 413-655 3.50e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  413 SENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDE---QIKQLEDALKDVQKRMYESEGKV 489
Cdd:COG1196   267 AELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEEleeELAELEEELEELEEELEELEEEL 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  490 KQMQTHFLALKEHLTS--EAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRL 567
Cdd:COG1196   347 EEAEEELEEAEAELAEaeEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEEL 426

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  568 QKELsmcemerekkgrkvtemegqAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKREL 647
Cdd:COG1196   427 EEAL--------------------AELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL 486


                  ....*...
gi 530406156  648 ENVKAKLA 655
Cdd:COG1196   487 AEAAARLL 494
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 413-710 3.75e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 41.54  E-value: 3.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  413 SENEILKKELEAMRTFCESAKQDRLklqnELAHKVAECKALALECERVKEDSDEQIKQ--LEDALKDVQKRMYESEGKVK 490
Cdd:NF033838  111 SEAELTSKTKKELDAAFEQFKKDTL----EPGKKVAEATKKVEEAEKKAKDQKEEDRRnyPTNTYKTLELEIAESDVEVK 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  491 QMQTHFLALKEHLTSEaasgnhrlteelKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGklIEENKRLQKE 570
Cdd:NF033838  187 KAELELVKEEAKEPRD------------EEKIKQAKAKVESKKAEATRLEKIKTDREKAEEEAKRRAD--AKLKEAVEKN 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  571 LSMCEMEREKKGRKVTEMEGQA----KELSAKLALSIPAEkfENMKS-SLSNE--VNEKAKKLVEMER------------ 631
Cdd:NF033838  253 VATSEQDKPKRRAKRGVLGEPAtpdkKENDAKSSDSSVGE--ETLPSpSLKPEkkVAEAEKKVEEAKKkakdqkeedrrn 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  632 ---------EHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKkiteltlknqtlqkeIEKVYLDN 702
Cdd:NF033838  331 yptntyktlELEIAESDVKVKEAELELVKEEAKEPRNEEKIKQAKAKVESKKAEATR---------------LEKIKTDR 395


                  ....*...
gi 530406156  703 KLLKEQAH 710
Cdd:NF033838  396 KKAEEEAK 403
PRK01156 PRK01156
chromosome segregation protein; Provisional
 883-1350 3.84e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.81  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  883 LKRNLENTQNQIKAEYISLAEHEAKMSSLsqsMRKVQDSNAEILANYRKGQEEIVTLHaEIKAQKKELDTIQECIKVKYA 962
Cdd:PRK01156  188 LEEKLKSSNLELENIKKQIADDEKSHSIT---LKEIERLSIEYNNAMDDYNNLKSALN-ELSSLEDMKNRYESEIKTAES 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  963 PIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALS---- 1038
Cdd:PRK01156  264 DLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLSVLQKDYNdyik 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1039 --RKTDELNKQLKDLSQ---KYT----EVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKE 1109
Cdd:PRK01156  344 kkSRYDDLNNQILELEGyemDYNsylkSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISS 423

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1110 ELKSMQ---RCYEKEQQTVTKLHQLLENQKNSSVpLAEHLqikeAFEKEVGIIKASLREKE--EESQNKME-EVSKLQSE 1183
Cdd:PRK01156  424 KVSSLNqriRALRENLDELSRNMEMLNGQSVCPV-CGTTL----GEEKSNHIINHYNEKKSrlEEKIREIEiEVKDIDEK 498

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1184 VQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANL---NRKYEEVCEEVLHAKKKEISAKDEKELLHFS--- 1257
Cdd:PRK01156  499 IVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELkdkHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAvis 578

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1258 -------------IEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTytsgNP 1324
Cdd:PRK01156  579 lidietnrsrsneIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGKI----DN 654

                         490       500
                  ....*....|....*....|....*.
gi 530406156 1325 TKRQSQLIDTLQHQVKSLEQQLADAD 1350
Cdd:PRK01156  655 YKKQIAEIDSIIPDLKEITSRINDIE 680
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 292-650 3.87e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 3.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  292 DLKERLRKIQQEQRILldKVNGLQLQLNEREKLKSLLAAKEKQHEESLRTIEALKNRFKyfesdhlgsgSHFSNRKEDML 371
Cdd:COG1196   217 ELKEELKELEAELLLL--KLRELEAELEELEAELEELEAELEELEAELAELEAELEELR----------LELEELELELE 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  372 LKQGQMYMADSQctspgipahmqsrsmlrplelslpsqtsYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECK 451
Cdd:COG1196   285 EAQAEEYELLAE----------------------------LARLEQDIARLEERRRELEERLEELEEELAELEEELEELE 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  452 ALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSE--AASGNHRLTEELKDQLKDLKVKY 529
Cdd:COG1196   337 EELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAlrAAAELAAQLEELEEAEEALLERL 416

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  530 EGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELsmcEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFE 609
Cdd:COG1196   417 ERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEE---EALLELLAELLEEAALLEAALAELLEELAEAAARL 493

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 530406156  610 NMKSSLSNEVNE-----KAKKLVEMEREHEKSLSEIRQLKRELENV 650
Cdd:COG1196   494 LLLLEAEADYEGflegvKAALLLAGLRGLAGAVAVLIGVEAAYEAA 539
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 17-252 4.00e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 41.61  E-value: 4.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156    17 DWNKYDDRLMKAAERGDVekvtSILAKKGVNPGKLDVE-----GRSVFHVVTSKGNLECLNAILI-HGVDITTSDTAgrn 90
Cdd:TIGR00870   13 PLSDEEKAFLPAAERGDL----ASVYRDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLLnLSCRGAVGDTL--- 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156    91 aLHLAAKyghalclqkllqyncptEHADLQGRTALHDAAMADCPSSIQLlcdhgasVNAKDVD----GRTPLVLATQMSR 166
Cdd:TIGR00870   86 -LHAISL-----------------EYVDAVEAILLHLLAAFRKSGPLEL-------ANDQYTSeftpGITALHLAAHRQN 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   167 PTICQLLIDRGADVNSR-------DKQNRTALMLGcEY--------GCRDAVEVLIKNGADISLLDALGHdssyyarigd 231
Cdd:TIGR00870  141 YEIVKLLLERGASVPARacgdffvKSQGVDSFYHG-ESplnaaaclGSPSIVALLSEDPADILTADSLGN---------- 209

                          250       260
                   ....*....|....*....|.
gi 530406156   232 nlDILTLLKTASENTNKGREL 252
Cdd:TIGR00870  210 --TLLHLLVMENEFKAEYEEL 228
PRK11281 PRK11281
mechanosensitive channel MscK;
977-1390 4.69e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.44  E-value: 4.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  977 TEKELKDQLseqtqkysvseEEVKKNKQENDKLKkeifTLQKDLRDKTVLIEKSHEMERalsrKTDELNKQLKDLSQKYT 1056
Cdd:PRK11281   37 TEADVQAQL-----------DALNKQKLLEAEDK----LVQQDLEQTLALLDKIDRQKE----ETEQLKQQLAQAPAKLR 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1057 EVKNVKEKLVEENAKQTSEILAVQNL--LQKQhvpLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVT-------K 1127
Cdd:PRK11281   98 QAQAELEALKDDNDEETRETLSTLSLrqLESR---LAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQAALYansqrlqQ 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1128 LHQLLENQKNSSVPLAEHLQIKEAFEKevgiikASLREKEEESQNKMEEVSKLQsevqntkqalkkletrevvDLskYKA 1207
Cdd:PRK11281  175 IRNLLKGGKVGGKALRPSQRVLLQAEQ------ALLNAQNDLQRKSLEGNTQLQ-------------------DL--LQK 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1208 TKSDLETQISSLNEKLANLnrkyeevcEEVLHAKKKEISAKDEKEllhfsieQEIKDQKERCDKSLTTITELQRRIQESA 1287
Cdd:PRK11281  228 QRDYLTARIQRLEHQLQLL--------QEAINSKRLTLSEKTVQE-------AQSQDEAARIQANPLVAQELEINLQLSQ 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1288 KQIEAKDnKITELLNDVERLKQALNGLSQltytsgnpTKR---------------------QSQLIDTLQhQVKSLEQQL 1346
Cdd:PRK11281  293 RLLKATE-KLNTLTQQNLRVKNWLDRLTQ--------SERnikeqisvlkgslllsrilyqQQQALPSAD-LIEGLADRI 362

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530406156 1347 ADAdRQHQ-EV---------IAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL 1390
Cdd:PRK11281  363 ADL-RLEQfEInqqrdalfqPDAYIDKLEAGHKSEVTDEVRDALLQLLDERREL 415
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 534-1192 4.76e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 41.70  E-value: 4.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   534 AEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELsmcemerekkgRKVTEMEGQAKELSAKLAlsipaekfenmks 613
Cdd:pfam01576   12 EELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQL-----------QAETELCAEAEEMRARLA------------- 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   614 slsnevnEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKP-----EEHEQVKSRLEQKSGELGKKITELTLKN 688
Cdd:pfam01576   68 -------ARKQELEEILHELESRLEEEEERSQQLQNEKKKMQQHIQDleeqlDEEEAARQKLQLEKVTTEAKIKKLEEDI 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   689 QTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLldvtQKYTEKKLEMEKLllendsl 768
Cdd:pfam01576  141 LLLEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERL----KKEEKGRQELEKA------- 209

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   769 skdvsrletvfvpPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALtsentnlkkmmsnqyvpvKTHEEVKMTL 848
Cdd:pfam01576  210 -------------KRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAA------------------LARLEEETAQ 258

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   849 NDTLAKTNRELL-DVKKKFEDINQEFVKiKDKNEILKRNLENTQNQIKAEyislaeheakmsslsqsMRKVQDSNAEILA 927
Cdd:pfam01576  259 KNNALKKIRELEaQISELQEDLESERAA-RNKAEKQRRDLGEELEALKTE-----------------LEDTLDTTAAQQE 320

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   928 NYRKGQEEIVTLHAEIKAQKKELDTiqecikvkyapivSFEECERKFKATEKELKDQLsEQTQKYSVSEEevkKNKQend 1007
Cdd:pfam01576  321 LRSKREQEVTELKKALEEETRSHEA-------------QLQEMRQKHTQALEELTEQL-EQAKRNKANLE---KAKQ--- 380

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1008 KLKKEIFTLQKDLRdktVLIEKSHEMERalsrKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQ--- 1084
Cdd:pfam01576  381 ALESENAELQAELR---TLQQAKQDSEH----KRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNeae 453

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1085 -KQHVPLEQVEALKKSLNGTIENLKEELKsmqrcyeKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASL 1163
Cdd:pfam01576  454 gKNIKLSKDVSSLESQLQDTQELLQEETR-------QKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQL 526

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 530406156  1164 R------EKEEESQNKMEEVSK-LQSEVQNTKQALK 1192
Cdd:pfam01576  527 SdmkkklEEDAGTLEALEEGKKrLQRELEALTQQLE 562
PHA02798 PHA02798
ankyrin-like protein; Provisional
 37-248 5.00e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.97  E-value: 5.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   37 VTSILAKKGVNPGKLDVEGRSVFHVVTSKG---NLECLNAILIHGVDITTSDTAGRNALHLAAKYGHA-------LCLQK 106
Cdd:PHA02798   91 IVKILIENGADINKKNSDGETPLYCLLSNGyinNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHidieiikLLLEK 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  107 LLQYNcptEHADLQGRTALH-------DAAMADCpssIQLLCDHGASVNAKDVDGRTPLVlatqmsrPTICQLLIDRGA- 178
Cdd:PHA02798  171 GVDIN---THNNKEKYDTLHcyfkyniDRIDADI---LKLFVDNGFIINKENKSHKKKFM-------EYLNSLLYDNKRf 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  179 ------------DVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHdssyyarigdnldilTLLKTASENT 246
Cdd:PHA02798  238 kknildfifsyiDINQVDELGFNPLYYSVSHNNRKIFEYLLQLGGDINIITELGN---------------TCLFTAFENE 302


                  ..
gi 530406156  247 NK 248
Cdd:PHA02798  303 SK 304
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
442-820 5.34e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.18  E-value: 5.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  442 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLtseaasgnhrltEELKDQ 521
Cdd:PRK02224  255 TLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARR------------EELEDR 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  522 LKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLAL 601
Cdd:PRK02224  323 DEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGD 402

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  602 SipAEKFENMkSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKA-----KLAQHVKPEEHEQVKSRLEQKSGE 676
Cdd:PRK02224  403 A--PVDLGNA-EDFLEELREERDELREREAELEATLRTARERVEEAEALLEagkcpECGQPVEGSPHVETIEEDRERVEE 479

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  677 LGKKITELTLKNQTLQKEIEKVyldnkllkeqahnltiemknhyvplkvsEDMKKSHDAiIDDLNRKLLDVTQKYTEKKL 756
Cdd:PRK02224  480 LEAELEDLEEEVEEVEERLERA----------------------------EDLVEAEDR-IERLEERREDLEELIAERRE 530

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530406156  757 EMEKLLLENDSLSKDVSRLETvfvPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHAL 820
Cdd:PRK02224  531 TIEEKRERAEELRERAAELEA---EAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESL 591
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 430-677 6.53e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 6.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  430 ESAKQDRLKLQNELAHKVAECKALALECERVK---EDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLtse 506
Cdd:COG4942    23 AEAEAELEQLQQEIAELEKELAALKKEEKALLkqlAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL--- 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  507 aasgnHRLTEELKDQLKDLkVKYEGASAEVGKLR----NQIKQNEMIVEEFKRDEGKLIEENKRLQKELSmcemerekkg 582
Cdd:COG4942   100 -----EAQKEELAELLRAL-YRLGRQPPLALLLSpedfLDAVRRLQYLKYLAPARREQAEELRADLAELA---------- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  583 RKVTEMEGQAKELSAKLAlsipaeKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRE---LENVKAKLAQHVK 659
Cdd:COG4942   164 ALRAELEAERAELEALLA------ELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEaeeLEALIARLEAEAA 237

                         250
                  ....*....|....*...
gi 530406156  660 PEEHEQVKSRLEQKSGEL 677
Cdd:COG4942   238 AAAERTPAAGFAALKGKL 255
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 103-191 6.60e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 40.90  E-value: 6.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  103 CLQKLLqyNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNA---------KDVD-----GRTPLVLATQMSRPT 168
Cdd:cd22194   125 ILDRFI--NAEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAhakgvffnpKYKHegfyfGETPLALAACTNQPE 202

                          90       100
                  ....*....|....*....|....
gi 530406156  169 ICQLLIDRGAD-VNSRDKQNRTAL 191
Cdd:cd22194   203 IVQLLMEKESTdITSQDSRGNTVL 226
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 784-1344 6.96e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.19  E-value: 6.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   784 KHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMmsnqyVPVKTHEEVKMTLNDTLAKTNRelLDVK 863
Cdd:TIGR01612  576 HLEKEIKDLFDKYLEIDDEIIYINKLKLELKEKIKNISDKNEYIKKA-----IDLKKIIENNNAYIDELAKISP--YQVP 648

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   864 KKFEDINQEFVKIKDK-NEILKRNLENTQNQ----IKAEYISLAEHEAKMSSLSQSMRKVQD--SNAEI------LANYR 930
Cdd:TIGR01612  649 EHLKNKDKIYSTIKSElSKIYEDDIDALYNElssiVKENAIDNTEDKAKLDDLKSKIDKEYDkiQNMETatvelhLSNIE 728

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   931 KGQEEIVTLHAEIKAQ-----KKELDTIQECIKVKYAPIVS-------FEECERKFKATEKELKDQLSEQTQKYSVSEEE 998
Cdd:TIGR01612  729 NKKNELLDIIVEIKKHihgeiNKDLNKILEDFKNKEKELSNkindyakEKDELNKYKSKISEIKNHYNDQINIDNIKDED 808

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   999 VKKNKQENDKLKKEIfTLQKDLRDKTV------------LIEKSHEMERALSRKTDELNKQLKDLSQKY-TEVKNVKEKL 1065
Cdd:TIGR01612  809 AKQNYDKSKEYIKTI-SIKEDEIFKIInemkfmkddflnKVDKFINFENNCKEKIDSEHEQFAELTNKIkAEISDDKLND 887

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1066 VEENAKQT-SEILAVQNLLQKQHvplEQVEALKKsLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSV---- 1140
Cdd:TIGR01612  888 YEKKFNDSkSLINEINKSIEEEY---QNINTLKK-VDEYIKICENTKESIEKFHNKQNILKEILNKNIDTIKESNLieks 963

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1141 --PLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREvvdlsKYKATkSDLETQISS 1218
Cdd:TIGR01612  964 ykDKFDNTLIDKINELDKAFKDASLNDYEAKNNELIKYFNDLKANLGKNKENMLYHQFDE-----KEKAT-NDIEQKIED 1037

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1219 LNEKLANLnrkyeevcEEVLHAKKKEISAKDEKELLHfSIEQEIKDQKERCDKSLTTITELQRRIQ-----ESAKQIEAK 1293
Cdd:TIGR01612 1038 ANKNIPNI--------EIAIHTSIYNIIDEIEKEIGK-NIELLNKEILEEAEINITNFNEIKEKLKhynfdDFGKEENIK 1108

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|...
gi 530406156  1294 -DNKITELLNDVERLKQALN-GLSQLTYTSgnptKRQSQLIDTLQHQVKSLEQ 1344
Cdd:TIGR01612 1109 yADEINKIKDDIKNLDQKIDhHIKALEEIK----KKSENYIDEIKAQINDLED 1157
Gp58 pfam07902
gp58-like protein; Sequences found in this family are derived from a number of bacteriophage ...
 1023-1339 7.95e-03

gp58-like protein; Sequences found in this family are derived from a number of bacteriophage and prophage proteins. They are similar to gp58, a minor structural protein of Lactococcus delbrueckii bacteriophage LL-H.


Pssm-ID: 369586 [Multi-domain]  Cd Length: 594  Bit Score: 40.71  E-value: 7.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1023 KTVLIEKSHE-------MERALSrKTDELNKQLKDL--SQKYTEVK-NVKEKLVE-ENAKQTSEILAVQNLLQKQHVplE 1091
Cdd:pfam07902   63 APVVVEGSGEstglfksLEEMLS-QLKELNLELTDTknSNLWSKIKlNNNGMLREyHNDTIKTEIVESAEGIATRIS--E 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1092 QVEALKKSLNGTIENLKEELKSMQR-CYEKEQQTVTKLHQLLENQKNSsvplaehlqikeafekevgiikaslrekeees 1170
Cdd:pfam07902  140 DTDKKLALINETISGIRREYQDADRqLSSSYQAGIEGLKATMASDKIG-------------------------------- 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1171 qnkmeevskLQSEVQNTKQALKKLETREVVDLS-KYKATKSDletQISSLNEKLANLNRKYEEVCEEVLHAKKKEISA-K 1248
Cdd:pfam07902  188 ---------LQAEIQASAQGLSQRYDNEIRKLSaKITTTSSG---TTEAYESKLDDLRAEFTRSNQGMRTELESKISGlQ 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  1249 DEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAkdnkitellndverLKQALNGL-SQLTYTSGNPTKR 1327
Cdd:pfam07902  256 STQQSTAYQISQEISNREGAVSRVQQDLDSYQRRLQDAEKNYSS--------------LTQTVKGLqSTVSDPNSKLESR 321

                          330
                   ....*....|..
gi 530406156  1328 QSQLIDTLQHQV 1339
Cdd:pfam07902  322 ITQLAGLIEQKV 333
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 742-1072 8.08e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 40.71  E-value: 8.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  742 RKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLET-----VFVPPEKHEKEIIALKSNIVELKKQLSELK-KKCGEDQE 815
Cdd:COG5185   196 KKAEPSGTVNSIKESETGNLGSESTLLEKAKEIINIeealkGFQDPESELEDLAQTSDKLEKLVEQNTDLRlEKLGENAE 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  816 KIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNR-ELLDVKKKFEDINQEFVKikdKNEILKRNLENTQNQI 894
Cdd:COG5185   276 SSKRLNENANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQlAAAEAEQELEESKRETET---GIQNLTAEIEQGQESL 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  895 KAEYISLaeheakmsslsqsmrKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKF 974
Cdd:COG5185   353 TENLEAI---------------KEEIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLEDTLKA 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  975 KATE-KELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIftlqkDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQ 1053
Cdd:COG5185   418 ADRQiEELQRQIEQATSSNEEVSKLLNELISELNKVMREA-----DEESQSRLEEAYDEINRSVRSKKEDLNEELTQIES 492

                         330
                  ....*....|....*....
gi 530406156 1054 KYTEVKNVKEKLVEENAKQ 1072
Cdd:COG5185   493 RVSTLKATLEKLRAKLERQ 511
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
 776-1176 8.14e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 40.61  E-value: 8.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  776 ETVFVPPEK--HEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNlkKMMSnqyvpvKTHEEVKMTLNDTLa 853
Cdd:PLN03229  409 EGVPVDPERkvNMKKREAVKTPVRELEGEVEKLKEQILKAKESSSKPSELALN--EMIE------KLKKEIDLEYTEAV- 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  854 ktnrELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQ 933
Cdd:PLN03229  480 ----IAMGLQERLENLREEFSKANSQDQLMHPVLMEKIEKLKDEFNKRLSRAPNYLSLKYKLDMLNEFSRAKALSEKKSK 555

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156  934 EEivTLHAEIKAQKKELDTIQEcikvkyapivsfeecerkFKATEKELKDQlseqtqkysVSEEEVKKNKQENDKLKKEI 1013
Cdd:PLN03229  556 AE--KLKAEINKKFKEVMDRPE------------------IKEKMEALKAE---------VASSGASSGDELDDDLKEKV 606

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1014 FTLQKDLRDKTVLIEKSHEMERALSRKTDelnkqlKDLSQKyTEVKNVKEKLVEENAKQTSEILAVQNLlqkqhvpleqv 1093
Cdd:PLN03229  607 EKMKKEIELELAGVLKSMGLEVIGVTKKN------KDTAEQ-TPPPNLQEKIESLNEEINKKIERVIRS----------- 668

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156 1094 ealkKSLNGTIENLKEEL-KSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVgiikASLREKEEESQN 1172
Cdd:PLN03229  669 ----SDLKSKIELLKLEVaKASKTPDVTEKEKIEALEQQIKQKIAEALNSSELKEKFEELEAEL----AAARETAAESNG 740


                  ....
gi 530406156 1173 KMEE 1176
Cdd:PLN03229  741 SLKN 744
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 153-181 8.26e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 8.26e-03
                           10        20
                   ....*....|....*....|....*....
gi 530406156   153 DGRTPLVLATQMSRPTICQLLIDRGADVN 181
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 469-1065 8.61e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 40.54  E-value: 8.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   469 KQLEDALKDVQKRMYESEGKV-------KQMQTHFLALKEHLTSEAASGNHRLTEE--LKDQLKDLKVKYEGASAEVGKL 539
Cdd:pfam01576   71 QELEEILHELESRLEEEEERSqqlqnekKKMQQHIQDLEEQLDEEEAARQKLQLEKvtTEAKIKKLEEDILLLEDQNSKL 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   540 RNQIKQNEMIVEEFKRDEGKLIEENKRLQK-----ELSMCEME----REKKGRKVTE-----MEGQAKELSAKLA----- 600
Cdd:pfam01576  151 SKERKLLEERISEFTSNLAEEEEKAKSLSKlknkhEAMISDLEerlkKEEKGRQELEkakrkLEGESTDLQEQIAelqaq 230

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   601 ----LSIPAEKFENMKSSLSNEVNEKAKK--LVEMEREHEKSLSEI------------------RQLKRELENVKAKLAQ 656
Cdd:pfam01576  231 iaelRAQLAKKEEELQAALARLEEETAQKnnALKKIRELEAQISELqedleseraarnkaekqrRDLGEELEALKTELED 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   657 HVKPEEHEQ-VKSRLEQKSGELGKKITELT--------------------LKNQTLQKEIEKVYLD--NKLLKEQAHNLT 713
Cdd:pfam01576  311 TLDTTAAQQeLRSKREQEVTELKKALEEETrsheaqlqemrqkhtqaleeLTEQLEQAKRNKANLEkaKQALESENAELQ 390

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   714 IEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVppeKHEKEIIALK 793
Cdd:pfam01576  391 AELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNI---KLSKDVSSLE 467

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   794 SNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQyvpvkthEEVKMTLNDTLAKTNRELLDVKKKFEDINQEF 873
Cdd:pfam01576  468 SQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQLSDMKKKLEEDAGTL 540

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   874 VKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKV---QDSNAEILANYRKGQEEIVTLHAEIKAqkkel 950
Cdd:pfam01576  541 EALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLlvdLDHQRQLVSNLEKKQKKFDQMLAEEKA----- 615

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   951 dtiqecIKVKYApivsfEECER-KFKATEKELKD-QLSEQTQKYSVSEEEVKKNkqeNDKLKKEIFTL--QKDLRDKTVl 1026
Cdd:pfam01576  616 ------ISARYA-----EERDRaEAEAREKETRAlSLARALEEALEAKEELERT---NKQLRAEMEDLvsSKDDVGKNV- 680

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|..
gi 530406156  1027 ieksHEME---RALSRKTDELNKQLKDLSQKYTEVKNVKEKL 1065
Cdd:pfam01576  681 ----HELErskRALEQQVEEMKTQLEELEDELQATEDAKLRL 718
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 727-1017 9.03e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 40.40  E-value: 9.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   727 EDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLlleNDSLSKDVSRLETVfvppekhEKEIIALKSNiVELKKQLSEL 806
Cdd:pfam05667  327 EELQQQREEELEELQEQLEDLESSIQELEKEIKKL---ESSIKQVEEELEEL-------KEQNEELEKQ-YKVKKKTLDL 395

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   807 KKKCGEDQEKIHALTSENTNLKKMMSNQY----VP-VKTHEEVKmtlndtLAKTNRELlDVKKKFEDINQEFVKIKDKNE 881
Cdd:pfam05667  396 LPDAEENIAKLQALVDASAQRLVELAGQWekhrVPlIEEYRALK------EAKSNKED-ESQRKLEEIKELREKIKEVAE 468

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530406156   882 ILKRNlENTQNQIKAEYISLAeheaKMSSLSQSMRKVqdsnAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIkvky 961
Cdd:pfam05667  469 EAKQK-EELYKQLVAEYERLP----KDVSRSAYTRRI----LEIVKNIKKQKEEITKILSDTKSLQKEINSLTGKL---- 535

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530406156   962 apivsfeecERKFKATEKEL-----KDQLSEQTQKYSVSE----EEVKKNKQENDKLKKEIFTLQ 1017
Cdd:pfam05667  536 ---------DRTFTVTDELVfkdakKDESVRKAYKYLAALhencEQLIQTVEETGTIMREIRDLE 591
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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