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Conserved domains on  [gi|530409454|ref|XP_005255774|]
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rab11 family-interacting protein 3 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
206-264 9.93e-09

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 51.87  E-value: 9.93e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530409454  206 RLRAVFDALDGDGDGFVRIEDFIQFATVYGA------EQVKDLTKYLDPSGLGVISFEDFYQGIT 264
Cdd:pfam13499   3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLEEgeplsdEEVEELFKEFDLDKDGRISFEEFLELYS 67
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 3-219 6.73e-05

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 6.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454   3 SAPPASPPGSEPPGPDPEPGGPDGPGAAQLAPGPAELRLGAPVGGPDPQSPGLDEPAPGAAADGGARWSAGPAPGLEGGP 82
Cdd:PRK07764 591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454  83 RDPGPSAPPPRSGPRGQLASPDAPGPGPRSEAPLPeldplfSWTEEPEecgPASCPESAPfRLQGSSSSHRARGEVDVFS 162
Cdd:PRK07764 671 AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP------AATPPAG---QADDPAAQP-PQAAQGASAPSPAADDPVP 740

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530409454 163 PFPAPTAGELALEQGPGSPPQPSDLSQTHPLPSEPVGSQEDGPRLRAVFDALDGDGD 219
Cdd:PRK07764 741 LPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDED 797
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
206-264 9.93e-09

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 51.87  E-value: 9.93e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530409454  206 RLRAVFDALDGDGDGFVRIEDFIQFATVYGA------EQVKDLTKYLDPSGLGVISFEDFYQGIT 264
Cdd:pfam13499   3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLEEgeplsdEEVEELFKEFDLDKDGRISFEEFLELYS 67
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
201-264 3.43e-08

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 52.10  E-value: 3.43e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530409454 201 QEDGPRLRAVFDALDGDGDGFVRIEDFIQFATVYG--AEQVKDLTKYLDPSGLGVISFEDFYQGIT 264
Cdd:COG5126   65 ATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGvsEEEADELFARLDTDGDGKISFEEFVAAVR 130
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 206-264 1.24e-05

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 42.92  E-value: 1.24e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530409454 206 RLRAVFDALDGDGDGFVRIEDFIQFATVYGAEQVKDLTKYL----DPSGLGVISFEDFYQGIT 264
Cdd:cd00051    1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMirevDKDGDGKIDFEEFLELMA 63
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3-219 6.73e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 6.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454   3 SAPPASPPGSEPPGPDPEPGGPDGPGAAQLAPGPAELRLGAPVGGPDPQSPGLDEPAPGAAADGGARWSAGPAPGLEGGP 82
Cdd:PRK07764 591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454  83 RDPGPSAPPPRSGPRGQLASPDAPGPGPRSEAPLPeldplfSWTEEPEecgPASCPESAPfRLQGSSSSHRARGEVDVFS 162
Cdd:PRK07764 671 AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP------AATPPAG---QADDPAAQP-PQAAQGASAPSPAADDPVP 740

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530409454 163 PFPAPTAGELALEQGPGSPPQPSDLSQTHPLPSEPVGSQEDGPRLRAVFDALDGDGD 219
Cdd:PRK07764 741 LPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDED 797
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
206-264 9.93e-09

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 51.87  E-value: 9.93e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530409454  206 RLRAVFDALDGDGDGFVRIEDFIQFATVYGA------EQVKDLTKYLDPSGLGVISFEDFYQGIT 264
Cdd:pfam13499   3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLEEgeplsdEEVEELFKEFDLDKDGRISFEEFLELYS 67
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
201-264 3.43e-08

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 52.10  E-value: 3.43e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530409454 201 QEDGPRLRAVFDALDGDGDGFVRIEDFIQFATVYG--AEQVKDLTKYLDPSGLGVISFEDFYQGIT 264
Cdd:COG5126   65 ATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGvsEEEADELFARLDTDGDGKISFEEFVAAVR 130
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 206-264 1.24e-05

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 42.92  E-value: 1.24e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530409454 206 RLRAVFDALDGDGDGFVRIEDFIQFATVYGAEQVKDLTKYL----DPSGLGVISFEDFYQGIT 264
Cdd:cd00051    1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMirevDKDGDGKIDFEEFLELMA 63
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3-219 6.73e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 6.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454   3 SAPPASPPGSEPPGPDPEPGGPDGPGAAQLAPGPAELRLGAPVGGPDPQSPGLDEPAPGAAADGGARWSAGPAPGLEGGP 82
Cdd:PRK07764 591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454  83 RDPGPSAPPPRSGPRGQLASPDAPGPGPRSEAPLPeldplfSWTEEPEecgPASCPESAPfRLQGSSSSHRARGEVDVFS 162
Cdd:PRK07764 671 AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP------AATPPAG---QADDPAAQP-PQAAQGASAPSPAADDPVP 740

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530409454 163 PFPAPTAGELALEQGPGSPPQPSDLSQTHPLPSEPVGSQEDGPRLRAVFDALDGDGD 219
Cdd:PRK07764 741 LPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDED 797
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1-206 1.19e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.59  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454   1 MASAPPASPPGSEPPGPDPEPGGPDGPGAAQLAPGPAELRLGAPVGGPDPQSPGLDEPAPGAAADGGARWSAGPAPGLEG 80
Cdd:PRK07764 603 PASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPP 682

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454  81 GPRDPGPSAPPPRSGPRGQLASPDAPGPGPRSEAPLPEldplfsWTEEPEECGPASCPESAPFRLQGSSSSHRARGEVDV 160
Cdd:PRK07764 683 PAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQ------PPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPA 756

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 530409454 161 FSPFPAPTAGelalEQGPGSPPQPSDLSQTHPLPSEPVGSQEDGPR 206
Cdd:PRK07764 757 QPPPPPAPAP----AAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDR 798
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
76-205 5.10e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.56  E-value: 5.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454  76 PGLEGGPRDPGPSAPPPRSGPRGQLASPDAPGPGPRSEAPLPELDPLFSWTEEPEECGPASCPESAPFRLQGSSSSHRAR 155
Cdd:PRK12323 365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530409454 156 GEVD--VFSPFPAPTAGELALEQGPGSPPQPSDLSQTHPLPSEPVGSQEDGP 205
Cdd:PRK12323 445 GGAPapAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDP 496
EF-hand_6 pfam13405
EF-hand domain;
206-235 1.74e-03

EF-hand domain;


Pssm-ID: 463869 [Multi-domain]  Cd Length: 30  Bit Score: 36.00  E-value: 1.74e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 530409454  206 RLRAVFDALDGDGDGFVRIEDFIQFATVYG 235
Cdd:pfam13405   1 ELREAFKLFDKDGDGKISLEELRKALRSLG 30
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 73-206 2.06e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.82  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454  73 GPAPGLEGGPRDPGPSAPPPRSGPRGQLASPDAPGPGPRSEAPLPELdplfSWTEEPeecgpascpeSAPFRLQGssssh 152
Cdd:PRK14959 388 GPASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATPAPSAAPSPRV----PWDDAP----------PAPPRSGI----- 448

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530409454 153 rargevdvfSPFPAPTAGELALEQG-PGSPPQPSDLSQTHPLPSEPVGSQEDGPR 206
Cdd:PRK14959 449 ---------PPRPAPRMPEASPVPGaPDSVASASDAPPTLGDPSDTAEHTPSGPR 494
PHA03132 PHA03132
thymidine kinase; Provisional
 72-212 2.19e-03

thymidine kinase; Provisional


Pssm-ID: 222997 [Multi-domain]  Cd Length: 580  Bit Score: 40.52  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454  72 AGPAPGLEGGPRDPGPSAPPprSGPRGQLASPDAPGPGPRSEAPLPELDPlfswtEEPEECGPASCPEsapfrlqgSSSS 151
Cdd:PHA03132  56 PPRETGSGGGVATSTIYTVP--RPPRGPEQTLDKPDSLPASRELPPGPTP-----VPPGGFRGASSPR--------LGAD 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530409454 152 HRARGevdvFSPFPAPTAGeLALEQGPGSPPQPSDLSQTH--PLPSEPVGSQEDGPRLRAVFD 212
Cdd:PHA03132 121 STSPR----FLYQVNFPVI-LAPIGESNSSSEELSEEEEHsrPPPSESLKVKNGGKVYPKGFS 178
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
206-265 3.24e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.85  E-value: 3.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454 206 RLRAVFDALDGDGDGFVRIEDFIQFAtvygAEQVKDLTKYLDPSGLGVISFEDFYQGITA 265
Cdd:COG5126    6 KLDRRFDLLDADGDGVLERDDFEALF----RRLWATLFSEADTDGDGRISREEFVAGMES 61
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2-213 3.74e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.86  E-value: 3.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454   2 ASAPPASPPgseppgpDPEPGGPDGPGAAQLAPGPAELRLGAPVGGPDPQSPGLdEPAPGAAADGGARWSAGPAPGLEGG 81
Cdd:PRK12323 384 QPAPAAAAP-------AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAP-EALAAARQASARGPGGAPAPAPAPA 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454  82 PRdPGPSAPPPRSGPRGQ-LASPDAPGPGPRSEAPLPELDPLFSWTEEPEECGPASCPESAPFRLQGSSSSHRARGEVDV 160
Cdd:PRK12323 456 AA-PAAAARPAAAGPRPVaAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADP 534

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530409454 161 FSPFPAPTAgelaleqGPGSPPQPSDLSQTHPLPSePVGSQEDGPRLRAVFDA 213
Cdd:PRK12323 535 DDAFETLAP-------APAAAPAPRAAAATEPVVA-PRPPRASASGLPDMFDG 579
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-206 4.95e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 4.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454    4 APPASPPGSEPPGPDPEPGGPDGPGAAQLAPGPAELRLGAPVGGPDPQSPGLDEPAPGAAADGGARwSAGPAPGLEGGPR 83
Cdd:PHA03247 2603 DDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR-RLGRAAQASSPPQ 2681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454   84 DPGPSAPPPRSGPRGQLASPDAPGPGPRSeAPLPELDPLfswteePEECGPASCPESAPfrlqgsssshrargeVDVFSP 163
Cdd:PHA03247 2682 RPRRRAARPTVGSLTSLADPPPPPPTPEP-APHALVSAT------PLPPGPAAARQASP---------------ALPAAP 2739

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 530409454  164 FPAPTAGELALEQGPGSPPQPSdLSQTHPLPSEPVGSQEDGPR 206
Cdd:PHA03247 2740 APPAVPAGPATPGGPARPARPP-TTAGPPAPAPPAAPAAGPPR 2781
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1-205 8.85e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 8.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454    1 MASAPPASPPGSEPPGPDPEPGGPDGPGAAQLAPGPAelrlgAPVGGPDPQ---------SPGLDEPAPGAAADGGARWS 71
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPA-----APAAGPPRRltrpavaslSESRESLPSPWDPADPPAAV 2811

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530409454   72 AGPAPGLEGGPRDPGPSAPPPRSGPrgqLASPDAPGPGPRSEAPLPELDPLFSWTEEPEECGPASCPeSAPFRLQGSSSS 151
Cdd:PHA03247 2812 LAPAAALPPAASPAGPLPPPTSAQP---TAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKP-AAPARPPVRRLA 2887

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530409454  152 hrargevdvfSPFPAPTAGELALEQ-GPGSPPQPSDLSQTHPLPSEPVGSQEDGP 205
Cdd:PHA03247 2888 ----------RPAVSRSTESFALPPdQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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