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Conserved domains on  [gi|530377873|ref|XP_005263140|]
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probable E3 ubiquitin-protein ligase HERC6 isoform X1 [Homo sapiens]

Protein Classification

E3 ubiquitin-protein ligase HERC family protein( domain architecture ID 18804227)

E3 ubiquitin-protein ligase HERC (HECT and RCC1 domain) family protein similar to human E3 ISG15--protein ligase HERC5, the major E3 ligase for ISG15 conjugation, that functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 684-1026 1.29e-134

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


:

Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 410.03  E-value: 1.29e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  684 FILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMG-SCMWFPAK 762
Cdd:cd00078     1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  763 PKP---EKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCirF 839
Cdd:cd00078    81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDEDDLELT--F 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  840 SIH-----WDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIG 914
Cdd:cd00078   159 TIEldssfGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  915 NTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPET-FSERDHPT 993
Cdd:cd00078   239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNPKFTIRRVgSPDDRLPT 318

                         330       340       350
                  ....*....|....*....|....*....|...
gi 530377873  994 SITCHNILSLPKYSTMERMEEALQVAINNNRGF 1026
Cdd:cd00078   319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGF 351
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 27-325 4.44e-67

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 229.09  E-value: 4.44e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873   27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPVVVGGcfvlfpkepiqaLETlIVDlVSCGKEHSLAVCHKG 106
Cdd:COG5184     2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPG------------LSN-VVA-VAAGGDHTCALKADG 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  107 RVFAWGAGSEGQLGIGEfKEISFTPKKIMTLNDIKiiQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGkEFPSQASPQR 186
Cdd:COG5184    68 TVWCWGNNSYGQLGDGT-TTDRTTPVKVPGLTGVV--AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQ 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  187 VR-SLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNVPVQSNKPLSVGALKnlGVVYISCGDAHTAVLTQ 265
Cdd:COG5184   144 VDaGLSGV--VAIAAGGYHTCALKSDGTVWCWGANSYGQL---GDGTTTDRPTPVQVGGLS--GVVAVAAGGDHSCALKS 216

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  266 DGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGlVSQIDCGSYHTLAyVHTTGQVVSFG 325
Cdd:COG5184   217 DGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG-VVAIAAGGSHTCA-LKSDGTVWCWG 274
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 684-1026 1.29e-134

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 410.03  E-value: 1.29e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  684 FILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMG-SCMWFPAK 762
Cdd:cd00078     1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  763 PKP---EKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCirF 839
Cdd:cd00078    81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDEDDLELT--F 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  840 SIH-----WDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIG 914
Cdd:cd00078   159 TIEldssfGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  915 NTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPET-FSERDHPT 993
Cdd:cd00078   239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNPKFTIRRVgSPDDRLPT 318

                         330       340       350
                  ....*....|....*....|....*....|...
gi 530377873  994 SITCHNILSLPKYSTMERMEEALQVAINNNRGF 1026
Cdd:cd00078   319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGF 351
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 738-1026 1.13e-77

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 256.77  E-value: 1.13e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873   738 EEMTKPEYGMFMYPEMGSC-MWF----PAKPKPEKKRYF-LFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKE 811
Cdd:pfam00632    5 KELFDPNYGLFEYETEDDRtYWFnpssSESPDLELLDYFkFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLES 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873   812 LSPRLGKSLQEvLDDAADDIGDALCIRFSI--HWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQR 889
Cdd:pfam00632   85 IDPELYKSLKS-LLNMDNDDDEDLGLTFTIpvFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRK 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873   890 GFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLH 969
Cdd:pfam00632  164 GFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLP 243

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 530377873   970 ARGIQKMEIVFRCPETFSERDH-PTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1026
Cdd:pfam00632  244 VGGFKSLPKFTIVRKGGDDDDRlPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGF 301
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 711-1026 3.36e-74

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 248.30  E-value: 3.36e-74
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873    711 KVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKP---KPEKKRYFLF-GMLCGLSLFNLNV 786
Cdd:smart00119    5 RVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSgfaNEEHLSYFRFiGRVLGKALYDNRL 84

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873    787 ANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCirFSIHwDQND------VDLIPNGISIPVD 860
Cdd:smart00119   85 LDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLLLNNDTSEELDLT--FSIV-LTSEfgqvkvVELKPGGSNIPVT 161

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873    861 QTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTI 940
Cdd:smart00119  162 EENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQTI 241

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873    941 QLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSERDH-PTSITCHNILSLPKYSTMERMEEALQVA 1019
Cdd:smart00119  242 KWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSPKFTIRKAGSDDERlPTAHTCFNRLKLPPYSSKEILREKLLLA 321


                    ....*..
gi 530377873   1020 INNNRGF 1026
Cdd:smart00119  322 INEGKGF 328
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 27-325 4.44e-67

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 229.09  E-value: 4.44e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873   27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPVVVGGcfvlfpkepiqaLETlIVDlVSCGKEHSLAVCHKG 106
Cdd:COG5184     2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPG------------LSN-VVA-VAAGGDHTCALKADG 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  107 RVFAWGAGSEGQLGIGEfKEISFTPKKIMTLNDIKiiQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGkEFPSQASPQR 186
Cdd:COG5184    68 TVWCWGNNSYGQLGDGT-TTDRTTPVKVPGLTGVV--AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQ 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  187 VR-SLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNVPVQSNKPLSVGALKnlGVVYISCGDAHTAVLTQ 265
Cdd:COG5184   144 VDaGLSGV--VAIAAGGYHTCALKSDGTVWCWGANSYGQL---GDGTTTDRPTPVQVGGLS--GVVAVAAGGDHSCALKS 216

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  266 DGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGlVSQIDCGSYHTLAyVHTTGQVVSFG 325
Cdd:COG5184   217 DGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG-VVAIAAGGSHTCA-LKSDGTVWCWG 274
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
590-1026 1.19e-64

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 235.43  E-value: 1.19e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  590 RLPENTFNINELSNLLNFYID-RGRQLFRDNHLIPAETPSPVIFsDFPFIFNSLSKIKLLQA---DSHIKMQMSEKK--- 662
Cdd:COG5021   400 GQFLFSDFLTSSSTYEDLRREqLGRESDESFYVASNVQQQRASR-EGPLLSGWKTRLNNLYRfyfVEHRKKTLTKNDsrl 478

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  663 --AYMLMHETILQKKDEF-------------PPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGG 727
Cdd:COG5021   479 gsFISLNKLDIRRIKEDKrrklfyslkqkakIFDPYLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGG 558

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  728 VSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKP---KPEKKRYFLF-GMLCGLSLFNLNVANLPFPLALYKKLLDQK 803
Cdd:COG5021   559 LTREWLFLLSKEMFNPDYGLFEYITEDLYTLPINPLssiNPEHLSYFKFlGRVIGKAIYDSRILDVQFSKAFYKKLLGKP 638

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  804 PSLEDLKELSPRLGKSLQEVLDDAADDIGdaLCIRFSI-HWDQND---VDLIPNGISIPVDQTNKRDYVSKYIDYIFNVS 879
Cdd:COG5021   639 VSLVDLESLDPELYRSLVWLLNNDIDETI--LDLTFTVeDDSFGEsrtVELIPNGRNISVTNENKKEYVKKVVDYKLNKR 716

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  880 VKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIG-NTDYDWKQFEQNSKYeQGYQKSHPTIQLFWKAFHKLTLDEKKKF 958
Cdd:COG5021   717 VEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGiPEDIDIDDWKSNTAY-HGYTEDSPIIVWFWEIISEFDFEERAKL 795

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530377873  959 LFFLTGRDRLHARGIQ----KMEIVFRCPETFSERDH--PTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1026
Cdd:COG5021   796 LQFVTGTSRIPINGFKdlqgSDGVRKFTIEKGGTDDDrlPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGF 869
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
105-155 1.48e-16

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 74.48  E-value: 1.48e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 530377873   105 KGRVFAWGAGSEGQLGIGEFKEiSFTPKKIMTLNDIKIIQVSCGHYHSLAL 155
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTEN-VLVPQKVEGLSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
HECTc cd00078
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
 684-1026 1.29e-134

HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.


Pssm-ID: 238033 [Multi-domain]  Cd Length: 352  Bit Score: 410.03  E-value: 1.29e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  684 FILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMG-SCMWFPAK 762
Cdd:cd00078     1 LKITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDsGLLYPNPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  763 PKP---EKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCirF 839
Cdd:cd00078    81 SFAdedHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDEDDLELT--F 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  840 SIH-----WDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIG 914
Cdd:cd00078   159 TIEldssfGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  915 NTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPET-FSERDHPT 993
Cdd:cd00078   239 SEDIDLEDLKKNTEYKGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLNPKFTIRRVgSPDDRLPT 318

                         330       340       350
                  ....*....|....*....|....*....|...
gi 530377873  994 SITCHNILSLPKYSTMERMEEALQVAINNNRGF 1026
Cdd:cd00078   319 AHTCFNLLKLPPYSSKEILREKLLYAINEGAGF 351
HECT pfam00632
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
 738-1026 1.13e-77

HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.


Pssm-ID: 459880  Cd Length: 304  Bit Score: 256.77  E-value: 1.13e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873   738 EEMTKPEYGMFMYPEMGSC-MWF----PAKPKPEKKRYF-LFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLKE 811
Cdd:pfam00632    5 KELFDPNYGLFEYETEDDRtYWFnpssSESPDLELLDYFkFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLEDLES 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873   812 LSPRLGKSLQEvLDDAADDIGDALCIRFSI--HWDQNDVDLIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQR 889
Cdd:pfam00632   85 IDPELYKSLKS-LLNMDNDDDEDLGLTFTIpvFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLEAFRK 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873   890 GFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLH 969
Cdd:pfam00632  164 GFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYDGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGSSRLP 243

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 530377873   970 ARGIQKMEIVFRCPETFSERDH-PTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1026
Cdd:pfam00632  244 VGGFKSLPKFTIVRKGGDDDDRlPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEGEGF 301
HECTc smart00119
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
 711-1026 3.36e-74

Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.


Pssm-ID: 214523  Cd Length: 328  Bit Score: 248.30  E-value: 3.36e-74
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873    711 KVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKP---KPEKKRYFLF-GMLCGLSLFNLNV 786
Cdd:smart00119    5 RVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSgfaNEEHLSYFRFiGRVLGKALYDNRL 84

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873    787 ANLPFPLALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGDALCirFSIHwDQND------VDLIPNGISIPVD 860
Cdd:smart00119   85 LDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLLLNNDTSEELDLT--FSIV-LTSEfgqvkvVELKPGGSNIPVT 161

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873    861 QTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQNSKYEQGYQKSHPTI 940
Cdd:smart00119  162 EENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYKGGYSANSQTI 241

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873    941 QLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSERDH-PTSITCHNILSLPKYSTMERMEEALQVA 1019
Cdd:smart00119  242 KWFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSPKFTIRKAGSDDERlPTAHTCFNRLKLPPYSSKEILREKLLLA 321


                    ....*..
gi 530377873   1020 INNNRGF 1026
Cdd:smart00119  322 INEGKGF 328
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 27-325 4.44e-67

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 229.09  E-value: 4.44e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873   27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPVVVGGcfvlfpkepiqaLETlIVDlVSCGKEHSLAVCHKG 106
Cdd:COG5184     2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPG------------LSN-VVA-VAAGGDHTCALKADG 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  107 RVFAWGAGSEGQLGIGEfKEISFTPKKIMTLNDIKiiQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGkEFPSQASPQR 186
Cdd:COG5184    68 TVWCWGNNSYGQLGDGT-TTDRTTPVKVPGLTGVV--AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQ 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  187 VR-SLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNVPVQSNKPLSVGALKnlGVVYISCGDAHTAVLTQ 265
Cdd:COG5184   144 VDaGLSGV--VAIAAGGYHTCALKSDGTVWCWGANSYGQL---GDGTTTDRPTPVQVGGLS--GVVAVAAGGDHSCALKS 216

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  266 DGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGlVSQIDCGSYHTLAyVHTTGQVVSFG 325
Cdd:COG5184   217 DGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG-VVAIAAGGSHTCA-LKSDGTVWCWG 274
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-327 2.13e-65

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 224.09  E-value: 2.13e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873    3 FCWGADSR-ELQRRRTAGSPGAELL-------QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPVVVGGcfv 74
Cdd:COG5184    20 WCWGDNSYgQLGDGTTTDRSTPVRVpglsnvvAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPG--- 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873   75 lfpkepiqaLETliVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEiSFTPKKImTLNDIKIIQVSCGHYHSLA 154
Cdd:COG5184    97 ---------LTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTN-RLTPVQV-DAGLSGVVAIAAGGYHTCA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  155 LSKDSQVFSWGKNSHGQLGLGkEFPSQASPQRVRSLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNVPV 234
Cdd:COG5184   164 LKSDGTVWCWGANSYGQLGDG-TTTDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQL---GDGTTT 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  235 QSNKPLSVGALKNlgVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGlVSQIDCGSYHTLAy 314
Cdd:COG5184   238 DRATPVQVAGLTG--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG-VVAVAAGSSHTCA- 313

                         330
                  ....*....|...
gi 530377873  315 VHTTGQVVSFGHG 327
Cdd:COG5184   314 LLTDGTVWCWGDN 326
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
590-1026 1.19e-64

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 235.43  E-value: 1.19e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  590 RLPENTFNINELSNLLNFYID-RGRQLFRDNHLIPAETPSPVIFsDFPFIFNSLSKIKLLQA---DSHIKMQMSEKK--- 662
Cdd:COG5021   400 GQFLFSDFLTSSSTYEDLRREqLGRESDESFYVASNVQQQRASR-EGPLLSGWKTRLNNLYRfyfVEHRKKTLTKNDsrl 478

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  663 --AYMLMHETILQKKDEF-------------PPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGG 727
Cdd:COG5021   479 gsFISLNKLDIRRIKEDKrrklfyslkqkakIFDPYLHIKVRRDRVFEDSYREIMDESGDDLKKTLEIEFVGEEGIDAGG 558

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  728 VSSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKP---KPEKKRYFLF-GMLCGLSLFNLNVANLPFPLALYKKLLDQK 803
Cdd:COG5021   559 LTREWLFLLSKEMFNPDYGLFEYITEDLYTLPINPLssiNPEHLSYFKFlGRVIGKAIYDSRILDVQFSKAFYKKLLGKP 638

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  804 PSLEDLKELSPRLGKSLQEVLDDAADDIGdaLCIRFSI-HWDQND---VDLIPNGISIPVDQTNKRDYVSKYIDYIFNVS 879
Cdd:COG5021   639 VSLVDLESLDPELYRSLVWLLNNDIDETI--LDLTFTVeDDSFGEsrtVELIPNGRNISVTNENKKEYVKKVVDYKLNKR 716

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  880 VKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIG-NTDYDWKQFEQNSKYeQGYQKSHPTIQLFWKAFHKLTLDEKKKF 958
Cdd:COG5021   717 VEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGiPEDIDIDDWKSNTAY-HGYTEDSPIIVWFWEIISEFDFEERAKL 795

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530377873  959 LFFLTGRDRLHARGIQ----KMEIVFRCPETFSERDH--PTSITCHNILSLPKYSTMERMEEALQVAINNNRGF 1026
Cdd:COG5021   796 LQFVTGTSRIPINGFKdlqgSDGVRKFTIEKGGTDDDrlPSAHTCFNRLKLPEYSSKEKLRSKLLTAINEGAGF 869
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-292 2.20e-57

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 201.74  E-value: 2.20e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873    3 FCWGADSR------ELQRRRT----AGSPGAEllQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPVVVGgc 72
Cdd:COG5184    70 WCWGNNSYgqlgdgTTTDRTTpvkvPGLTGVV--AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVD-- 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873   73 fvlfpkepiQALETlIVDlVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISfTPKKIMTLNDIkiIQVSCGHYHS 152
Cdd:COG5184   146 ---------AGLSG-VVA-IAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRP-TPVQVGGLSGV--VAVAAGGDHS 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  153 LALSKDSQVFSWGKNSHGQLGLGkEFPSQASPQRVRSLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNV 232
Cdd:COG5184   212 CALKSDGTVWCWGSNSSGQLGDG-TTTDRATPVQVAGLTGV--VAIAAGGSHTCALKSDGTVWCWGDNSYGQL---GDGT 285

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  233 PVQSNKPLSVGALKNlgVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQ 292
Cdd:COG5184   286 TTDRSTPVKVPGLSG--VVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 143-329 5.61e-42

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 157.45  E-value: 5.61e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  143 IQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSqASPQRVRSLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSA 222
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDR-STPVRVPGLSNV--VAVAAGGDHTCALKADGTVWCWGNNSY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530377873  223 GQLalsGRNVPVQSNKPLSVGALKNlgVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVS 302
Cdd:COG5184    78 GQL---GDGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSGVV 152

                         170       180
                  ....*....|....*....|....*..
gi 530377873  303 QIDCGSYHTLAyVHTTGQVVSFGHGPS 329
Cdd:COG5184   153 AIAAGGYHTCA-LKSDGTVWCWGANSY 178
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
105-155 1.48e-16

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 74.48  E-value: 1.48e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 530377873   105 KGRVFAWGAGSEGQLGIGEFKEiSFTPKKIMTLNDIKIIQVSCGHYHSLAL 155
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTEN-VLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
158-208 3.29e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 67.54  E-value: 3.29e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 530377873   158 DSQVFSWGKNSHGQLGLGKEFpSQASPQRVRSLEGIPLAQVAAGGAHSFAL 208
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
266-313 3.02e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 56.37  E-value: 3.02e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 530377873   266 DGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGSYHTLA 313
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNkVVQVACGGDHTVA 49
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
142-171 1.40e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 53.97  E-value: 1.40e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 530377873   142 IIQVSCGHYHSLALSKDSQVFSWGKNSHGQ 171
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
250-279 7.67e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 52.04  E-value: 7.67e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 530377873   250 VVYISCGDAHTAVLTQDGKVFTFGDNRSGQ 279
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
215-263 5.20e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 50.21  E-value: 5.20e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 530377873   215 FGWGSNSAGQLalsGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVL 263
Cdd:pfam00415    5 YTWGRNDYGQL---GLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
27-54 2.57e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.03  E-value: 2.57e-05
                           10        20
                   ....*....|....*....|....*...
gi 530377873    27 QAASGERHSLLLLTNHRVLSCGDNSRGQ 54
Cdd:pfam13540    3 SVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
89-118 1.04e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 40.10  E-value: 1.04e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 530377873    89 VDLVSCGKEHSLAVCHKGRVFAWGAGSEGQ 118
Cdd:pfam13540    1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
196-224 1.53e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 39.71  E-value: 1.53e-04
                           10        20
                   ....*....|....*....|....*....
gi 530377873   196 AQVAAGGAHSFALSLCGTSFGWGSNSAGQ 224
Cdd:pfam13540    2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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