ERBB receptor feedback inhibitor 1 isoform X2 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Inhibitor_Mig-6 super family | cl13070 | EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen ... |
264-316 | 4.56e-10 | ||
EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains.The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive. The actual alignment was detected with superfamily member pfam11555: Pssm-ID: 463294 [Multi-domain] Cd Length: 74 Bit Score: 55.39 E-value: 4.56e-10
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| Name | Accession | Description | Interval | E-value | ||
| Inhibitor_Mig-6 | pfam11555 | EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen ... |
264-316 | 4.56e-10 | ||
EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains.The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive. Pssm-ID: 463294 [Multi-domain] Cd Length: 74 Bit Score: 55.39 E-value: 4.56e-10
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| Name | Accession | Description | Interval | E-value | ||
| Inhibitor_Mig-6 | pfam11555 | EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen ... |
264-316 | 4.56e-10 | ||
EGFR receptor inhibitor Mig-6; When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains.The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive. Pssm-ID: 463294 [Multi-domain] Cd Length: 74 Bit Score: 55.39 E-value: 4.56e-10
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