NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|530360621|ref|XP_005263544|]
View 

migration and invasion-inhibitory protein isoform X2 [Homo sapiens]

Protein Classification

MIIP domain-containing protein( domain architecture ID 11238985)

MIIP domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
MIIP pfam15734
Migration and invasion-inhibitory; This family of proteins binds to insulin-like growth factor ...
66-366 1.07e-171

Migration and invasion-inhibitory; This family of proteins binds to insulin-like growth factor binding protein 2 (IGFBP-2) and inhibits the invasion of glioma cells.


:

Pssm-ID: 464831  Cd Length: 337  Bit Score: 481.59  E-value: 1.07e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530360621   66 CPRGRSSVWG-PPDACRGDLRDVARSGVASLPPAKCQHQESLGRPRPHSAPSLGTSSLRDPEPSGRLGDPGPQEAQTPRS 144
Cdd:pfam15734  28 CPQDARHPDAhQGDPCDVAWGGAVSSRVASLPPAKCQHQESLGRPRPHSAPLLATSDLKDPEPSAGLSDLGPQEAQALRS 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530360621  145 ILAQQSKLSKPRVTFSEESAVPKRSWRLRPYLGYDWIAGSLDTSSSITSQPEAFFSKLQEFRETNKEECICSHPEPQLPG 224
Cdd:pfam15734 108 ILARQSKPSKPRVTFCEESAVPESSWRLRPYLGYDWIAGSLDNSSPVTSKPEAFFSKLQEFREANKEECIHSAPEPQFLG 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530360621  225 LRESSGsgVEEDHECVYCYRVNRRLFPVPVDPGTPCRLCRTPRDQQGPGTLAQPAHVRVSIPLSILEPPHRYHIHRRKSF 304
Cdd:pfam15734 188 LRESSG--VEEDHECVYCYRVNRRLFLVPLDPGTPCRLCRTPRSQRGPETLAEPAQVRVSIPLSILDPPHRYRIHRRKSF 265
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530360621  305 DASDTLALPRHCLLGWDIFPPKSEKSSAPRNLDLWSSVSAEAQHQKLSGTSSPFHPGPALQP 366
Cdd:pfam15734 266 DASDTLALPRHCLLGWDILPPKSEKSSAPKSLDLWSSVSSEAQHRKLSASSPSHLALPSRVP 327
 
Name Accession Description Interval E-value
MIIP pfam15734
Migration and invasion-inhibitory; This family of proteins binds to insulin-like growth factor ...
66-366 1.07e-171

Migration and invasion-inhibitory; This family of proteins binds to insulin-like growth factor binding protein 2 (IGFBP-2) and inhibits the invasion of glioma cells.


Pssm-ID: 464831  Cd Length: 337  Bit Score: 481.59  E-value: 1.07e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530360621   66 CPRGRSSVWG-PPDACRGDLRDVARSGVASLPPAKCQHQESLGRPRPHSAPSLGTSSLRDPEPSGRLGDPGPQEAQTPRS 144
Cdd:pfam15734  28 CPQDARHPDAhQGDPCDVAWGGAVSSRVASLPPAKCQHQESLGRPRPHSAPLLATSDLKDPEPSAGLSDLGPQEAQALRS 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530360621  145 ILAQQSKLSKPRVTFSEESAVPKRSWRLRPYLGYDWIAGSLDTSSSITSQPEAFFSKLQEFRETNKEECICSHPEPQLPG 224
Cdd:pfam15734 108 ILARQSKPSKPRVTFCEESAVPESSWRLRPYLGYDWIAGSLDNSSPVTSKPEAFFSKLQEFREANKEECIHSAPEPQFLG 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530360621  225 LRESSGsgVEEDHECVYCYRVNRRLFPVPVDPGTPCRLCRTPRDQQGPGTLAQPAHVRVSIPLSILEPPHRYHIHRRKSF 304
Cdd:pfam15734 188 LRESSG--VEEDHECVYCYRVNRRLFLVPLDPGTPCRLCRTPRSQRGPETLAEPAQVRVSIPLSILDPPHRYRIHRRKSF 265
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530360621  305 DASDTLALPRHCLLGWDIFPPKSEKSSAPRNLDLWSSVSAEAQHQKLSGTSSPFHPGPALQP 366
Cdd:pfam15734 266 DASDTLALPRHCLLGWDILPPKSEKSSAPKSLDLWSSVSSEAQHRKLSASSPSHLALPSRVP 327
 
Name Accession Description Interval E-value
MIIP pfam15734
Migration and invasion-inhibitory; This family of proteins binds to insulin-like growth factor ...
66-366 1.07e-171

Migration and invasion-inhibitory; This family of proteins binds to insulin-like growth factor binding protein 2 (IGFBP-2) and inhibits the invasion of glioma cells.


Pssm-ID: 464831  Cd Length: 337  Bit Score: 481.59  E-value: 1.07e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530360621   66 CPRGRSSVWG-PPDACRGDLRDVARSGVASLPPAKCQHQESLGRPRPHSAPSLGTSSLRDPEPSGRLGDPGPQEAQTPRS 144
Cdd:pfam15734  28 CPQDARHPDAhQGDPCDVAWGGAVSSRVASLPPAKCQHQESLGRPRPHSAPLLATSDLKDPEPSAGLSDLGPQEAQALRS 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530360621  145 ILAQQSKLSKPRVTFSEESAVPKRSWRLRPYLGYDWIAGSLDTSSSITSQPEAFFSKLQEFRETNKEECICSHPEPQLPG 224
Cdd:pfam15734 108 ILARQSKPSKPRVTFCEESAVPESSWRLRPYLGYDWIAGSLDNSSPVTSKPEAFFSKLQEFREANKEECIHSAPEPQFLG 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530360621  225 LRESSGsgVEEDHECVYCYRVNRRLFPVPVDPGTPCRLCRTPRDQQGPGTLAQPAHVRVSIPLSILEPPHRYHIHRRKSF 304
Cdd:pfam15734 188 LRESSG--VEEDHECVYCYRVNRRLFLVPLDPGTPCRLCRTPRSQRGPETLAEPAQVRVSIPLSILDPPHRYRIHRRKSF 265
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530360621  305 DASDTLALPRHCLLGWDIFPPKSEKSSAPRNLDLWSSVSAEAQHQKLSGTSSPFHPGPALQP 366
Cdd:pfam15734 266 DASDTLALPRHCLLGWDILPPKSEKSSAPKSLDLWSSVSSEAQHRKLSASSPSHLALPSRVP 327
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH