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Conserved domains on  [gi|530376736|ref|XP_005265774|]
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mitochondria-eating protein isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIEAP super family cl24557
Mitochondria-eating protein; This domain is found at the C-terminus of mitochondria-eating ...
 298-342 2.22e-09

Mitochondria-eating protein; This domain is found at the C-terminus of mitochondria-eating proteins. This family of proteins regulate mitochondrial quality. They have a role in the degradation of damaged mitochondrial proteins and in the degradation of damaged mitochondria.


The actual alignment was detected with superfamily member pfam16026:

Pssm-ID: 464982  Cd Length: 198  Bit Score: 56.49  E-value: 2.22e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 530376736  298 RKAALLSRFSDSYSQARLDAQCLLRRCI-DKAETVQRIIYIATVMS 342
Cdd:pfam16026   1 RPSKLVERFSELYSNERLDAFEALDRLIdLEEELVQKILFSILVEA 46
EnvC super family cl34844
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 119-251 4.78e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG4942:

Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.59  E-value: 4.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376736 119 RDMQQLDSNLNSTRSQCNQVQDDLVETEKNLEESKNRSAI---SLLAAEEEINQLKKQLKSLQAQEDARHR------NTD 189
Cdd:COG4942   34 QEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRAleqELAALEAELAELEKEIAELRAELEAQKEelaellRAL 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530376736 190 QRSSENRR------SEPWSLEERKREQWNSLKQnADQQDTEAMSDYKKQLRNLKEEIAVLSAEKSALQ 251
Cdd:COG4942  114 YRLGRQPPlalllsPEDFLDAVRRLQYLKYLAP-ARREQAEELRADLAELAALRAELEAERAELEALL 180
 
Name Accession Description Interval E-value
MIEAP pfam16026
Mitochondria-eating protein; This domain is found at the C-terminus of mitochondria-eating ...
 298-342 2.22e-09

Mitochondria-eating protein; This domain is found at the C-terminus of mitochondria-eating proteins. This family of proteins regulate mitochondrial quality. They have a role in the degradation of damaged mitochondrial proteins and in the degradation of damaged mitochondria.


Pssm-ID: 464982  Cd Length: 198  Bit Score: 56.49  E-value: 2.22e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 530376736  298 RKAALLSRFSDSYSQARLDAQCLLRRCI-DKAETVQRIIYIATVMS 342
Cdd:pfam16026   1 RPSKLVERFSELYSNERLDAFEALDRLIdLEEELVQKILFSILVEA 46
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 119-251 4.78e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.59  E-value: 4.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376736 119 RDMQQLDSNLNSTRSQCNQVQDDLVETEKNLEESKNRSAI---SLLAAEEEINQLKKQLKSLQAQEDARHR------NTD 189
Cdd:COG4942   34 QEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRAleqELAALEAELAELEKEIAELRAELEAQKEelaellRAL 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530376736 190 QRSSENRR------SEPWSLEERKREQWNSLKQnADQQDTEAMSDYKKQLRNLKEEIAVLSAEKSALQ 251
Cdd:COG4942  114 YRLGRQPPlalllsPEDFLDAVRRLQYLKYLAP-ARREQAEELRADLAELAALRAELEAERAELEALL 180
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 126-251 9.14e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.11  E-value: 9.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376736   126 SNLNSTRSQCNQVQDDLVETEKNLE--ESKNRSAISLLAAEEEINQLKKQL--KSLQAQEDARHRNTDQRSSENRRSEPW 201
Cdd:TIGR02168  179 RKLERTRENLDRLEDILNELERQLKslERQAEKAERYKELKAELRELELALlvLRLEELREELEELQEELKEAEEELEEL 258

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 530376736   202 SLEERKREQWNSLKQNADQQDTEAMSDYKKQLRNLKEEIAVLSAEKSALQ 251
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILR 308
 
Name Accession Description Interval E-value
MIEAP pfam16026
Mitochondria-eating protein; This domain is found at the C-terminus of mitochondria-eating ...
 298-342 2.22e-09

Mitochondria-eating protein; This domain is found at the C-terminus of mitochondria-eating proteins. This family of proteins regulate mitochondrial quality. They have a role in the degradation of damaged mitochondrial proteins and in the degradation of damaged mitochondria.


Pssm-ID: 464982  Cd Length: 198  Bit Score: 56.49  E-value: 2.22e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 530376736  298 RKAALLSRFSDSYSQARLDAQCLLRRCI-DKAETVQRIIYIATVMS 342
Cdd:pfam16026   1 RPSKLVERFSELYSNERLDAFEALDRLIdLEEELVQKILFSILVEA 46
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 119-251 4.78e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.59  E-value: 4.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376736 119 RDMQQLDSNLNSTRSQCNQVQDDLVETEKNLEESKNRSAI---SLLAAEEEINQLKKQLKSLQAQEDARHR------NTD 189
Cdd:COG4942   34 QEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRAleqELAALEAELAELEKEIAELRAELEAQKEelaellRAL 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530376736 190 QRSSENRR------SEPWSLEERKREQWNSLKQnADQQDTEAMSDYKKQLRNLKEEIAVLSAEKSALQ 251
Cdd:COG4942  114 YRLGRQPPlalllsPEDFLDAVRRLQYLKYLAP-ARREQAEELRADLAELAALRAELEAERAELEALL 180
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 126-251 9.14e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.11  E-value: 9.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530376736   126 SNLNSTRSQCNQVQDDLVETEKNLE--ESKNRSAISLLAAEEEINQLKKQL--KSLQAQEDARHRNTDQRSSENRRSEPW 201
Cdd:TIGR02168  179 RKLERTRENLDRLEDILNELERQLKslERQAEKAERYKELKAELRELELALlvLRLEELREELEELQEELKEAEEELEEL 258

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 530376736   202 SLEERKREQWNSLKQNADQQDTEAMSDYKKQLRNLKEEIAVLSAEKSALQ 251
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILR 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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