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Conserved domains on  [gi|530403250|ref|XP_005267463|]
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nidogen-2 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G2F smart00682
G2 nidogen domain and fibulin;
552-784 1.01e-104

G2 nidogen domain and fibulin;


:

Pssm-ID: 214774  Cd Length: 227  Bit Score: 331.33  E-value: 1.01e-104
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250    552 PEGAPHRVNGKVSGHLHVGHTPVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENG 631
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVGEFPVAFENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAVNG 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250    632 FSLAGAAFTHDMEVTFyPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYSDS-TVTSTSSR 710
Cdd:smart00682   81 FQLTGGVFTRETEVTF-AGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTGPgVLTTSSTR 159

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530403250    711 DYSLtfgaINQTWSYRIHQNITYQVCRHAPRHPsfPTTQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSDP 784
Cdd:smart00682  160 EYTV----DNQTHSYTVDQTITFEECQHRDAFP--PTTQQLHVSSVFVDYNDEERVLRFAAHNSVGPGDESNQC 227
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
108-273 3.34e-51

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


:

Pssm-ID: 214712  Cd Length: 152  Bit Score: 177.23  E-value: 3.34e-51
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250    108 PFLADIDTsHGRGRVLYREDTSPAVLGLAARYVRAGFPRSARFTPTHAFLATWEQVGAYeevkrGALPSGELNTFQAVLA 187
Cdd:smart00539    1 PFWADADT-EGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAY-----GSQSSDGTNTFQAVLA 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250    188 SDGSDSYALFLYPANGLQFLGTRPKESynvqlQLPARVGFCRGEAddlksEGPYFSLTSTEQSVKNLYQLSNLGIPGVWA 267
Cdd:smart00539   75 TDGSRTYAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDG-----TFSYTLPASGEENIKNLAEGSNVGIPGRWM 144


                    ....*.
gi 530403250    268 FHIGST 273
Cdd:smart00539  145 FRVDGA 150
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 918-984 2.45e-26

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


:

Pssm-ID: 238114  Cd Length: 66  Bit Score: 102.93  E-value: 2.45e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530403250  918 PCEQQQRHAQAQYAYPGA-RFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGstPPHC 984
Cdd:cd00191     1 PCERERASALESLAGPKLsGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGG--PPNC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 998-1063 3.38e-23

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


:

Pssm-ID: 238114  Cd Length: 66  Bit Score: 94.07  E-value: 3.38e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530403250  998 CERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGtTPAC 1063
Cdd:cd00191     2 CERERASALESLAGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGG-PPNC 66
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1200-1244 8.55e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.77  E-value: 8.55e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 530403250   1200 KVLFYTDLVNPRAIAVDPIRGNLYWTDWNReaPKIETSSLDGENR 1244
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 875-908 2.63e-12

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 62.23  E-value: 2.63e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530403250   875 CSENR--CHPAATCYNTPGSFSCRCQPGYYGDGFQC 908
Cdd:pfam12947    1 CSDNNggCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1157-1199 7.40e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 7.40e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 530403250   1157 ETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSER 1199
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
828-870 3.41e-10

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 56.10  E-value: 3.41e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 530403250    828 DENECATGfHRCGPNSVCINLPGSYRCECRSGYEfadDRHTCI 870
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1245-1287 8.40e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 8.40e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 530403250   1245 RILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGR 1287
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 790-826 5.97e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.82  E-value: 5.97e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 530403250   790 CYDGSHMCDTTARCHPgTGVDYTCECASGYQGDGRNC 826
Cdd:pfam12947    1 CSDNNGGCHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 515-550 7.88e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.74  E-value: 7.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530403250   515 CEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHC 550
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1113-1151 2.73e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.59  E-value: 2.73e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 530403250   1113 KTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLE 1151
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
 
Name Accession Description Interval E-value
G2F smart00682
G2 nidogen domain and fibulin;
552-784 1.01e-104

G2 nidogen domain and fibulin;


Pssm-ID: 214774  Cd Length: 227  Bit Score: 331.33  E-value: 1.01e-104
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250    552 PEGAPHRVNGKVSGHLHVGHTPVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENG 631
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVGEFPVAFENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAVNG 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250    632 FSLAGAAFTHDMEVTFyPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYSDS-TVTSTSSR 710
Cdd:smart00682   81 FQLTGGVFTRETEVTF-AGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTGPgVLTTSSTR 159

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530403250    711 DYSLtfgaINQTWSYRIHQNITYQVCRHAPRHPsfPTTQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSDP 784
Cdd:smart00682  160 EYTV----DNQTHSYTVDQTITFEECQHRDAFP--PTTQQLHVSSVFVDYNDEERVLRFAAHNSVGPGDESNQC 227
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 554-778 6.09e-103

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


Pssm-ID: 238158  Cd Length: 224  Bit Score: 326.19  E-value: 6.09e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250  554 GAPHRVNGKVSGHLHVGHTPVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENGFS 633
Cdd:cd00255     1 GIPQRVNGKVSGNINVGQSPVEFGDADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNGFS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250  634 LAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYSDSTV-TSTSSRDY 712
Cdd:cd00255    81 LTGGEFTRQAEVTFYTGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPGVlTSSSTREY 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530403250  713 SLTFGAINQTWSYRIHQNITYQVCRHAPrhPSFPTTQQLNVDRVFALYNDEERVLRFAVTNQIGPV 778
Cdd:cd00255   161 TVDEGGESQTLSYQWNQTITYEECPHDD--EAAPDLQQLLVARIFALYNPEEEILRFAITNSIGPG 224
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 554-740 6.63e-75

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


Pssm-ID: 462175  Cd Length: 184  Bit Score: 246.35  E-value: 6.63e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250   554 GAPHRVNGKVSGHLhvghTPVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENGFS 633
Cdd:pfam07474    1 GVPQRVNGKVSGTI----NGVEFGDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFALEQGGAKNGFS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250   634 LAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYSDSTV-TSTSSRDY 712
Cdd:pfam07474   77 LTGGVFNRTAEVTFPPTGERLTITQEFRGLDEDGHLVVDTVISGTVPQVPAGSTVIIEDYTELYQYTGPGElTSSSTRTY 156

                          170       180
                   ....*....|....*....|....*...
gi 530403250   713 SLTFGAINQTWSYRIHQNITYQVCRHAP 740
Cdd:pfam07474  157 TVDGEGNTRTISYTVNQTITYQECRHAE 184
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
108-273 3.34e-51

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 177.23  E-value: 3.34e-51
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250    108 PFLADIDTsHGRGRVLYREDTSPAVLGLAARYVRAGFPRSARFTPTHAFLATWEQVGAYeevkrGALPSGELNTFQAVLA 187
Cdd:smart00539    1 PFWADADT-EGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAY-----GSQSSDGTNTFQAVLA 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250    188 SDGSDSYALFLYPANGLQFLGTRPKESynvqlQLPARVGFCRGEAddlksEGPYFSLTSTEQSVKNLYQLSNLGIPGVWA 267
Cdd:smart00539   75 TDGSRTYAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDG-----TFSYTLPASGEENIKNLAEGSNVGIPGRWM 144


                    ....*.
gi 530403250    268 FHIGST 273
Cdd:smart00539  145 FRVDGA 150
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 179-272 4.65e-33

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 123.17  E-value: 4.65e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250   179 LNTFQAVLASDGSDSYALFLYPANGLQFLGTRPKESYNVQLQLPARVGFCRGEaddlkSEGPYFSLT-STEQSVKNLYQL 257
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYPDGGIQWTTGKASGGTNGLGGTPAQAGFSAGD-----GDGRYYELPgSGTDSIRNLTET 75

                           90
                   ....*....|....*
gi 530403250   258 SNLGIPGVWAFHIGS 272
Cdd:pfam06119   76 SNVGVPGRWVFRIDS 90
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 918-984 2.45e-26

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 102.93  E-value: 2.45e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530403250  918 PCEQQQRHAQAQYAYPGA-RFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGstPPHC 984
Cdd:cd00191     1 PCERERASALESLAGPKLsGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGG--PPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 919-984 4.33e-26

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 102.38  E-value: 4.33e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530403250   919 CEQQQRHAQAQYAY--PGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGStpPHC 984
Cdd:pfam00086    1 CERERARALEQAASgrPASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGD--PDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 998-1063 3.38e-23

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 94.07  E-value: 3.38e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530403250  998 CERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGtTPAC 1063
Cdd:cd00191     2 CERERASALESLAGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGG-PPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 998-1063 6.04e-23

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 93.52  E-value: 6.04e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530403250   998 CERWRENLLEHY-GGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGtTPAC 1063
Cdd:pfam00086    1 CERERARALEQAaSGRPASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGG-DPDC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 939-984 4.65e-17

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 75.88  E-value: 4.65e-17
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 530403250    939 IPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPpgSTPPHC 984
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRTE--GGDPDC 44
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1019-1063 4.38e-16

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 73.18  E-value: 4.38e-16
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 530403250   1019 VPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRsQPGTTPAC 1063
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTR-TEGGDPDC 44
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1200-1244 8.55e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.77  E-value: 8.55e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 530403250   1200 KVLFYTDLVNPRAIAVDPIRGNLYWTDWNReaPKIETSSLDGENR 1244
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 875-908 2.63e-12

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 62.23  E-value: 2.63e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530403250   875 CSENR--CHPAATCYNTPGSFSCRCQPGYYGDGFQC 908
Cdd:pfam12947    1 CSDNNggCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1157-1199 7.40e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 7.40e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 530403250   1157 ETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSER 1199
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1177-1217 3.03e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 56.40  E-value: 3.03e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 530403250  1177 RTMYWTDSVLD-KIESALLDGSERKVLFYTDLVNPRAIAVDP 1217
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
828-870 3.41e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 56.10  E-value: 3.41e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 530403250    828 DENECATGfHRCGPNSVCINLPGSYRCECRSGYEfadDRHTCI 870
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1245-1287 8.40e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 8.40e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 530403250   1245 RILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGR 1287
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
872-909 1.51e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 54.56  E-value: 1.51e-09
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 530403250    872 VDEC-SENRCHPAATCYNTPGSFSCRCQPGYYgDGFQCI 909
Cdd:smart00179    2 IDECaSGNPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 872-904 5.30e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.02  E-value: 5.30e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530403250  872 VDEC-SENRCHPAATCYNTPGSFSCRCQPGYYGD 904
Cdd:cd00054     2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1064-1274 5.71e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 58.17  E-value: 5.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250 1064 IPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGR 1143
Cdd:COG3391    11 VLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250 1144 TISRAGLELGAEPETIVNSGliSPEGLAIDHIRRTMYWTDSVLDKIesALLDGSERKVLFYTDL-VNPRAIAVDPIRGNL 1222
Cdd:COG3391    91 RVSVIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRV--SVIDTATGKVVATIPVgAGPHGIAVDPDGKRL 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530403250 1223 YWTDW-NREAPKIeTSSLDGENRRILINTDIG-LPNGLTFDPFSKLLCWADAGT 1274
Cdd:COG3391   167 YVANSgSNTVSVI-VSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGS 219
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 828-861 5.73e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 5.73e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530403250  828 DENECATGfHRCGPNSVCINLPGSYRCECRSGYE 861
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
828-859 1.51e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 48.77  E-value: 1.51e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 530403250   828 DENECATGFHRCGPNSVCINLPGSYRCECRSG 859
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1220-1262 2.12e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 2.12e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 530403250  1220 GNLYWTDWNREApKIETSSLDGENRRILINTDIGLPNGLTFDP 1262
Cdd:pfam00058    1 GRLYWTDSSLRA-SISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 790-826 5.97e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.82  E-value: 5.97e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 530403250   790 CYDGSHMCDTTARCHPgTGVDYTCECASGYQGDGRNC 826
Cdd:pfam12947    1 CSDNNGGCHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 515-550 7.88e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.74  E-value: 7.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530403250   515 CEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHC 550
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1113-1151 2.73e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.59  E-value: 2.73e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 530403250   1113 KTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLE 1151
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1162-1228 1.77e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.81  E-value: 1.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530403250 1162 SGLISPEGLAIDHiRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPiRGNLYWTDWN 1228
Cdd:cd14952   133 TGLSNPDGVAVDG-AGNVYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDT-AGNVYVTDHG 197
 
Name Accession Description Interval E-value
G2F smart00682
G2 nidogen domain and fibulin;
552-784 1.01e-104

G2 nidogen domain and fibulin;


Pssm-ID: 214774  Cd Length: 227  Bit Score: 331.33  E-value: 1.01e-104
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250    552 PEGAPHRVNGKVSGHLHVGHTPVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENG 631
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVGEFPVAFENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAVNG 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250    632 FSLAGAAFTHDMEVTFyPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYSDS-TVTSTSSR 710
Cdd:smart00682   81 FQLTGGVFTRETEVTF-AGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTGPgVLTTSSTR 159

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530403250    711 DYSLtfgaINQTWSYRIHQNITYQVCRHAPRHPsfPTTQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSDP 784
Cdd:smart00682  160 EYTV----DNQTHSYTVDQTITFEECQHRDAFP--PTTQQLHVSSVFVDYNDEERVLRFAAHNSVGPGDESNQC 227
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 554-778 6.09e-103

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


Pssm-ID: 238158  Cd Length: 224  Bit Score: 326.19  E-value: 6.09e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250  554 GAPHRVNGKVSGHLHVGHTPVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENGFS 633
Cdd:cd00255     1 GIPQRVNGKVSGNINVGQSPVEFGDADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFALEQGGAKNGFS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250  634 LAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYSDSTV-TSTSSRDY 712
Cdd:cd00255    81 LTGGEFTRQAEVTFYTGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPGVlTSSSTREY 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530403250  713 SLTFGAINQTWSYRIHQNITYQVCRHAPrhPSFPTTQQLNVDRVFALYNDEERVLRFAVTNQIGPV 778
Cdd:cd00255   161 TVDEGGESQTLSYQWNQTITYEECPHDD--EAAPDLQQLLVARIFALYNPEEEILRFAITNSIGPG 224
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 554-740 6.63e-75

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


Pssm-ID: 462175  Cd Length: 184  Bit Score: 246.35  E-value: 6.63e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250   554 GAPHRVNGKVSGHLhvghTPVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENGFS 633
Cdd:pfam07474    1 GVPQRVNGKVSGTI----NGVEFGDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFALEQGGAKNGFS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250   634 LAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYSDSTV-TSTSSRDY 712
Cdd:pfam07474   77 LTGGVFNRTAEVTFPPTGERLTITQEFRGLDEDGHLVVDTVISGTVPQVPAGSTVIIEDYTELYQYTGPGElTSSSTRTY 156

                          170       180
                   ....*....|....*....|....*...
gi 530403250   713 SLTFGAINQTWSYRIHQNITYQVCRHAP 740
Cdd:pfam07474  157 TVDGEGNTRTISYTVNQTITYQECRHAE 184
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
108-273 3.34e-51

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 177.23  E-value: 3.34e-51
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250    108 PFLADIDTsHGRGRVLYREDTSPAVLGLAARYVRAGFPRSARFTPTHAFLATWEQVGAYeevkrGALPSGELNTFQAVLA 187
Cdd:smart00539    1 PFWADADT-EGTGKVYYRETTDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAY-----GSQSSDGTNTFQAVLA 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250    188 SDGSDSYALFLYPANGLQFLGTRPKESynvqlQLPARVGFCRGEAddlksEGPYFSLTSTEQSVKNLYQLSNLGIPGVWA 267
Cdd:smart00539   75 TDGSRTYAIFLYPSLGWTSDTTAGGDD-----GVRARAGFNGGDG-----TFSYTLPASGEENIKNLAEGSNVGIPGRWM 144


                    ....*.
gi 530403250    268 FHIGST 273
Cdd:smart00539  145 FRVDGA 150
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 179-272 4.65e-33

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 123.17  E-value: 4.65e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250   179 LNTFQAVLASDGSDSYALFLYPANGLQFLGTRPKESYNVQLQLPARVGFCRGEaddlkSEGPYFSLT-STEQSVKNLYQL 257
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYPDGGIQWTTGKASGGTNGLGGTPAQAGFSAGD-----GDGRYYELPgSGTDSIRNLTET 75

                           90
                   ....*....|....*
gi 530403250   258 SNLGIPGVWAFHIGS 272
Cdd:pfam06119   76 SNVGVPGRWVFRIDS 90
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 918-984 2.45e-26

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 102.93  E-value: 2.45e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530403250  918 PCEQQQRHAQAQYAYPGA-RFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGstPPHC 984
Cdd:cd00191     1 PCERERASALESLAGPKLsGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGG--PPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 919-984 4.33e-26

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 102.38  E-value: 4.33e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530403250   919 CEQQQRHAQAQYAY--PGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGStpPHC 984
Cdd:pfam00086    1 CERERARALEQAASgrPASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGGD--PDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 998-1063 3.38e-23

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 94.07  E-value: 3.38e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530403250  998 CERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGtTPAC 1063
Cdd:cd00191     2 CERERASALESLAGPKLSGLYVPQCDEDGNYEPVQCHGSTGYCWCVDPDGEEIPGTRTRGG-PPNC 66
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 998-1063 6.04e-23

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 93.52  E-value: 6.04e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530403250   998 CERWRENLLEHY-GGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGtTPAC 1063
Cdd:pfam00086    1 CERERARALEQAaSGRPASGLYIPNCDEDGFYKPVQCHGSTGYCWCVDPEGQEIPGTRTRGG-DPDC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 939-984 4.65e-17

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 75.88  E-value: 4.65e-17
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 530403250    939 IPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPpgSTPPHC 984
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTRTE--GGDPDC 44
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 1019-1063 4.38e-16

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 73.18  E-value: 4.38e-16
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 530403250   1019 VPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRsQPGTTPAC 1063
Cdd:smart00211    1 IPQCDEDGNYEPVQCDGSSGQCWCVDATGREIPGTR-TEGGDPDC 44
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1200-1244 8.55e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.77  E-value: 8.55e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 530403250   1200 KVLFYTDLVNPRAIAVDPIRGNLYWTDWNReaPKIETSSLDGENR 1244
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 875-908 2.63e-12

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 62.23  E-value: 2.63e-12
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530403250   875 CSENR--CHPAATCYNTPGSFSCRCQPGYYGDGFQC 908
Cdd:pfam12947    1 CSDNNggCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1157-1199 7.40e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 7.40e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 530403250   1157 ETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSER 1199
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1177-1217 3.03e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 56.40  E-value: 3.03e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 530403250  1177 RTMYWTDSVLD-KIESALLDGSERKVLFYTDLVNPRAIAVDP 1217
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
828-870 3.41e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 56.10  E-value: 3.41e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 530403250    828 DENECATGfHRCGPNSVCINLPGSYRCECRSGYEfadDRHTCI 870
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1245-1287 8.40e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 8.40e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 530403250   1245 RILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGR 1287
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
872-909 1.51e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 54.56  E-value: 1.51e-09
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 530403250    872 VDEC-SENRCHPAATCYNTPGSFSCRCQPGYYgDGFQCI 909
Cdd:smart00179    2 IDECaSGNPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 872-904 5.30e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.02  E-value: 5.30e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530403250  872 VDEC-SENRCHPAATCYNTPGSFSCRCQPGYYGD 904
Cdd:cd00054     2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1064-1274 5.71e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 58.17  E-value: 5.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250 1064 IPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGR 1143
Cdd:COG3391    11 VLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250 1144 TISRAGLELGAEPETIVNSGliSPEGLAIDHIRRTMYWTDSVLDKIesALLDGSERKVLFYTDL-VNPRAIAVDPIRGNL 1222
Cdd:COG3391    91 RVSVIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRV--SVIDTATGKVVATIPVgAGPHGIAVDPDGKRL 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 530403250 1223 YWTDW-NREAPKIeTSSLDGENRRILINTDIG-LPNGLTFDPFSKLLCWADAGT 1274
Cdd:COG3391   167 YVANSgSNTVSVI-VSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGS 219
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 828-861 5.73e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 5.73e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530403250  828 DENECATGfHRCGPNSVCINLPGSYRCECRSGYE 861
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
828-859 1.51e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 48.77  E-value: 1.51e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 530403250   828 DENECATGFHRCGPNSVCINLPGSYRCECRSG 859
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1220-1262 2.12e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 2.12e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 530403250  1220 GNLYWTDWNREApKIETSSLDGENRRILINTDIGLPNGLTFDP 1262
Cdd:pfam00058    1 GRLYWTDSSLRA-SISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 790-826 5.97e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.82  E-value: 5.97e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 530403250   790 CYDGSHMCDTTARCHPgTGVDYTCECASGYQGDGRNC 826
Cdd:pfam12947    1 CSDNNGGCHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 874-905 6.42e-07

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 47.09  E-value: 6.42e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 530403250  874 ECSE-NRCHPAATCYNTPGSFSCRCQPGYYGDG 905
Cdd:cd00053     1 ECAAsNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 832-869 1.04e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.44  E-value: 1.04e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 530403250   832 CATGFHRCGPNSVCINLPGSYRCECRSGYEFadDRHTC 869
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 515-550 7.88e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.74  E-value: 7.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530403250   515 CEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHC 550
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 831-861 9.53e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 43.62  E-value: 9.53e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 530403250  831 ECATgFHRCGPNSVCINLPGSYRCECRSGYE 861
Cdd:cd00053     1 ECAA-SNPCSNGGTCVNTPGSYRCVCPPGYT 30
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 845-869 1.17e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.39  E-value: 1.17e-05
                           10        20
                   ....*....|....*....|....*
gi 530403250   845 CINLPGSYRCECRSGYEFADDRHTC 869
Cdd:pfam14670   12 CLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
872-900 2.07e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 2.07e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 530403250   872 VDECSE--NRCHPAATCYNTPGSFSCRCQPG 900
Cdd:pfam07645    2 VDECATgtHNCPANTVCVNTIGSFECRCPDG 32
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1113-1151 2.73e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.59  E-value: 2.73e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 530403250   1113 KTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLE 1151
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLD 39
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 823-865 3.05e-05

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 46.99  E-value: 3.05e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 530403250  823 GRNCVDENECATGFHRCgpNSVCINLPGSYRCECRSGYEFADD 865
Cdd:cd01475   181 GKICVVPDLCATLSHVC--QQVCISTPGSYLCACTEGYALLED 221
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1135-1229 4.87e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 46.43  E-value: 4.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250 1135 VYWTDVAGRTIsragLELGAE---PETIVNSGLISPEGLAIDHiRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPR 1211
Cdd:cd14952    23 VYVADSGNNRV----LKLAAGsttQTVLPFTGLYQPQGVAVDA-AGTVYVTDFGNNRVLKLAAGSTTQTVLPFTGLNDPT 97

                          90       100
                  ....*....|....*....|
gi 530403250 1212 AIAVDPIrGNLYWTDW--NR 1229
Cdd:cd14952    98 GVAVDAA-GNVYVADTgnNR 116
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 875-904 8.16e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 8.16e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 530403250   875 CSENRCHPAATCYNTPGSFSCRCQPGYYGD 904
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF smart00181
Epidermal growth factor-like domain;
874-904 1.57e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 40.19  E-value: 1.57e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 530403250    874 ECSENR-CHPAaTCYNTPGSFSCRCQPGYYGD 904
Cdd:smart00181    1 ECASGGpCSNG-TCINTPGSYTCSCPPGYTGD 31
EGF smart00181
Epidermal growth factor-like domain;
831-870 6.64e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 38.27  E-value: 6.64e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 530403250    831 ECATGfHRCGpNSVCINLPGSYRCECRSGYEfadDRHTCI 870
Cdd:smart00181    1 ECASG-GPCS-NGTCINTPGSYTCSCPPGYT---GDKRCE 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1135-1174 8.41e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.29  E-value: 8.41e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 530403250  1135 VYWTDVA-GRTISRAGLElGAEPETIVNSGLISPEGLAIDH 1174
Cdd:pfam00058    3 LYWTDSSlRASISSADLN-GSDRKTLFTDDLQHPNAIAVDP 42
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 1125-1290 8.85e-04

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 42.63  E-value: 8.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250  1125 GIDYDCRERMVYWTDVAGRTISRAGLELGAEpETIVNSGLIspeGLAIDHIRRTMYwtdsVLDKIESALLDGSERKVLFY 1204
Cdd:pfam08450    4 GPVWDEEEGALYWVDILGGRIHRLDPATGKE-TVWDTPGPV---GAIAPRDDGGLI----VALKDGVALLDLATGELTPL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250  1205 TDLVNPRA-------IAVDPiRGNLYWTD-WNREAPKIETSSL---DGENRRILINTDIGLPNGLTFDPFSKLLCWADAG 1273
Cdd:pfam08450   76 ADPEDDDWplnrfndGKVDP-DGRFWFGTmGDDEAPGGDPGALyrlDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSP 154

                          170       180
                   ....*....|....*....|..
gi 530403250  1274 TKKL---ECTLPDGT--GRRVI 1290
Cdd:pfam08450  155 ARKIwayDYDLDGGLisNRRVF 176
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1130-1277 1.70e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 41.80  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250 1130 CRERMVYWTDVAGRTISRAGLELG-----AEPETIVNSGLISPEG--LAIDHIRRTmywtdsvldkiesALLDGSERKVL 1202
Cdd:COG3386    16 DPDGRLYWVDIPGGRIHRYDPDGGavevfAEPSGRPNGLAFDPDGrlLVADHGRGL-------------VRFDPADGEVT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250 1203 FYTDLVNPRA-----IAVDPiRGNLYWTDWNREAPkieTSSL-----DGENRRILinTDIGLPNGLTFDPFSKLLCWADA 1272
Cdd:COG3386    83 VLADEYGKPLnrpndGVVDP-DGRLYFTDMGEYLP---TGALyrvdpDGSLRVLA--DGLTFPNGIAFSPDGRTLYVADT 156


                  ....*
gi 530403250 1273 GTKKL 1277
Cdd:COG3386   157 GAGRI 161
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1162-1228 1.77e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.81  E-value: 1.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530403250 1162 SGLISPEGLAIDHiRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPiRGNLYWTDWN 1228
Cdd:cd14952   133 TGLSNPDGVAVDG-AGNVYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDT-AGNVYVTDHG 197
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1093-1262 2.61e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250 1093 QGQQIGYLPlngtrlQKDAAKTLLSlhgsiIVGIDYDcRERmVYWTDVAG-------------RTISRAGLELGAepeti 1159
Cdd:cd14963    85 DGKFLKYFP------EKKDRVKLIS-----PAGLAID-DGK-LYVSDVKKhkvivfdlegkllLEFGKPGSEPGE----- 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250 1160 vnsgLISPEGLAIDHIRRtMYWTDS------VLDKIESAL--LDGSerkVLFYTDLVNPRAIAVDPiRGNLYWTDwnREA 1231
Cdd:cd14963   147 ----LSYPNGIAVDEDGN-IYVADSgngriqVFDKNGKFIkeLNGS---PDGKSGFVNPRGIAVDP-DGNLYVVD--NLS 215

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 530403250 1232 PKIETSSLDGENRRIL-----INTDIGLPNGLTFDP 1262
Cdd:cd14963   216 HRVYVFDEQGKELFTFggrgkDDGQFNLPNGLFIDD 251
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1160-1344 2.91e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.16  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250 1160 VNSGLISPEGLAIDHiRRTMYWTDSVLDKIesALLDGSERKVLFY--TDLVNPRAIAVDPiRGNLYWTDWNREA-----P 1232
Cdd:COG4257    12 VPAPGSGPRDVAVDP-DGAVWFTDQGGGRI--GRLDPATGEFTEYplGGGSGPHGIAVDP-DGNLWFTDNGNNRigridP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530403250 1233 KietsslDGENRRILINTDIGLPNGLTFDPFSKLlcW-ADAGTKKL-----------ECTLPDGTGRrviqnnlkyPFSI 1300
Cdd:COG4257    88 K------TGEITTFALPGGGSNPHGIAFDPDGNL--WfTDQGGNRIgrldpatgevtEFPLPTGGAG---------PYGI 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 530403250 1301 VSYADHF-YHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITA 1344
Cdd:COG4257   151 AVDPDGNlWVTDFGANAIGRIDPDTGTLTEYALPTPGAGPRGLAV 195
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 812-831 7.45e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.08  E-value: 7.45e-03
                           10        20
                   ....*....|....*....|..
gi 530403250   812 TCECASGYQG--DGRNCVDENE 831
Cdd:pfam12662    1 TCSCPPGYQLdpDGRTCVDIDE 22
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 853-874 7.68e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.08  E-value: 7.68e-03
                           10        20
                   ....*....|....*....|..
gi 530403250   853 RCECRSGYEFADDRHTCIYVDE 874
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 880-901 7.99e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.00  E-value: 7.99e-03
                           10        20
                   ....*....|....*....|..
gi 530403250   880 CHPAATCYNTPGSFSCRCQPGY 901
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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