NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|530404461|ref|XP_005268046|]
View 

protein sel-1 homolog 1 isoform X2 [Homo sapiens]

Protein Classification

FN2 and TPR domain-containing protein( domain architecture ID 12186032)

FN2 and TPR domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
361-529 8.54e-40

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 147.00  E-value: 8.54e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 361 IQYYQFLAEKGDVQAQVGLGQLHLHgGRGVEQNHqmysegsdivpqsnETALHYFKKAADMGNPVGQSGLGMAYLYGRGV 440
Cdd:COG0790   87 LEWFEKAAEQGDAEAQYNLGLMYEE-GLGVPQDY--------------AKALEWYEKAAEQGDADAQYNLGLLYLNGEGV 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 441 QVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAV 520
Cdd:COG0790  152 PKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKAL 231


                 ....*....
gi 530404461 521 ELFKNVCER 529
Cdd:COG0790  232 RWLRKAAEQ 240
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 120-168 2.49e-25

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 98.91  E-value: 2.49e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 530404461   120 GTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 168
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
TPR COG0790
TPR repeat [General function prediction only];
186-324 3.90e-17

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 81.51  E-value: 3.90e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 186 MYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPKGQTALGFLY 265
Cdd:COG0790  102 QYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLY 181

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530404461 266 ASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANH 324
Cdd:COG0790  182 ENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 641-674 4.13e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


:

Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.75  E-value: 4.13e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530404461  641 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEA 674
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 606-639 1.04e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


:

Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.85  E-value: 1.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 530404461   606 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQH 639
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
361-529 8.54e-40

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 147.00  E-value: 8.54e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 361 IQYYQFLAEKGDVQAQVGLGQLHLHgGRGVEQNHqmysegsdivpqsnETALHYFKKAADMGNPVGQSGLGMAYLYGRGV 440
Cdd:COG0790   87 LEWFEKAAEQGDAEAQYNLGLMYEE-GLGVPQDY--------------AKALEWYEKAAEQGDADAQYNLGLLYLNGEGV 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 441 QVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAV 520
Cdd:COG0790  152 PKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKAL 231


                 ....*....
gi 530404461 521 ELFKNVCER 529
Cdd:COG0790  232 RWLRKAAEQ 240
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 120-168 2.49e-25

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 98.91  E-value: 2.49e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 530404461   120 GTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 168
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 121-168 1.00e-23

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 94.29  E-value: 1.00e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 530404461 121 TAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 168
Cdd:cd00062    1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
127-168 1.37e-21

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 88.01  E-value: 1.37e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 530404461  127 CHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 168
Cdd:pfam00040   1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
TPR COG0790
TPR repeat [General function prediction only];
186-324 3.90e-17

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 81.51  E-value: 3.90e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 186 MYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPKGQTALGFLY 265
Cdd:COG0790  102 QYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLY 181

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530404461 266 ASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANH 324
Cdd:COG0790  182 ENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 460-495 6.14e-08

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 49.09  E-value: 6.14e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530404461   460 VDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGH 495
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 424-458 3.36e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 47.13  E-value: 3.36e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 530404461  424 PVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQG 458
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 641-674 4.13e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.75  E-value: 4.13e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530404461  641 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEA 674
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 641-673 6.70e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 46.01  E-value: 6.70e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530404461   641 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAE 673
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 606-639 1.04e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.85  E-value: 1.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 530404461   606 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQH 639
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 255-290 5.11e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.23  E-value: 5.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530404461   255 PKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGN 290
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 606-637 6.13e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 34.80  E-value: 6.13e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 530404461  606 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQ 637
Cdd:pfam08238   3 AQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
361-529 8.54e-40

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 147.00  E-value: 8.54e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 361 IQYYQFLAEKGDVQAQVGLGQLHLHgGRGVEQNHqmysegsdivpqsnETALHYFKKAADMGNPVGQSGLGMAYLYGRGV 440
Cdd:COG0790   87 LEWFEKAAEQGDAEAQYNLGLMYEE-GLGVPQDY--------------AKALEWYEKAAEQGDADAQYNLGLLYLNGEGV 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 441 QVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAV 520
Cdd:COG0790  152 PKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKAL 231


                 ....*....
gi 530404461 521 ELFKNVCER 529
Cdd:COG0790  232 RWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
364-675 2.14e-38

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 143.15  E-value: 2.14e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 364 YQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVN 443
Cdd:COG0790    3 LAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 444 YDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELF 523
Cdd:COG0790   83 YEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWY 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 524 KnvcergrwserlmtaynsykdgdynaaviqylllaeqgyevaqsnaafildqreasivgenetyprallhwnRAASQGY 603
Cdd:COG0790  163 R------------------------------------------------------------------------KAAEQGD 170

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530404461 604 TVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHsAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEAS 675
Cdd:COG0790  171 ADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGD-ADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQA 241
TPR COG0790
TPR repeat [General function prediction only];
363-530 5.50e-38

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 141.99  E-value: 5.50e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 363 YYQFLAEKGDVQAQVGLGQLHLHGgRGVEQNHqmysegsdivpqsnETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQV 442
Cdd:COG0790   53 AAAAAAAAGGAEAQYNLGLMYAEG-RGVPKDY--------------EKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQ 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 443 NYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVEL 522
Cdd:COG0790  118 DYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEW 197


                 ....*...
gi 530404461 523 FKNVCERG 530
Cdd:COG0790  198 YRKAAEQG 205
TPR COG0790
TPR repeat [General function prediction only];
157-490 2.60e-31

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 122.73  E-value: 2.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 157 YDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLP 236
Cdd:COG0790    1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 237 QNIQAAREMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKAlvyytfgalggnliahmvlgyrywagigvlqscesalt 316
Cdd:COG0790   81 KDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKA-------------------------------------- 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 317 hyrlvanhvasdisltggsvvqrirlpdevenpgmnsgmleedlIQYYQFLAEKGDVQAQVGLGQLHLHgGRGVEQNHqm 396
Cdd:COG0790  123 --------------------------------------------LEWYEKAAEQGDADAQYNLGLLYLN-GEGVPKDP-- 155

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 397 ysegsdivpqsnETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGV 476
Cdd:COG0790  156 ------------AKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGV 223

                        330
                 ....*....|....
gi 530404461 477 KRDYKQALKYFNLA 490
Cdd:COG0790  224 EKDLEKALRWLRKA 237
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 120-168 2.49e-25

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 98.91  E-value: 2.49e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 530404461   120 GTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 168
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 121-168 1.00e-23

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 94.29  E-value: 1.00e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 530404461 121 TAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 168
Cdd:cd00062    1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
127-168 1.37e-21

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 88.01  E-value: 1.37e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 530404461  127 CHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFC 168
Cdd:pfam00040   1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
TPR COG0790
TPR repeat [General function prediction only];
186-324 3.90e-17

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 81.51  E-value: 3.90e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 186 MYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPKGQTALGFLY 265
Cdd:COG0790  102 QYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLY 181

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530404461 266 ASGLGVNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANH 324
Cdd:COG0790  182 ENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 460-495 6.14e-08

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 49.09  E-value: 6.14e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530404461   460 VDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGH 495
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 424-458 1.99e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 47.55  E-value: 1.99e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 530404461   424 PVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQG 458
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 424-458 3.36e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 47.13  E-value: 3.36e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 530404461  424 PVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQG 458
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 641-674 4.13e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.75  E-value: 4.13e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530404461  641 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEA 674
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 641-673 6.70e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 46.01  E-value: 6.70e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530404461   641 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAE 673
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 460-494 9.07e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 42.89  E-value: 9.07e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 530404461  460 VDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGG 494
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 606-639 1.04e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.85  E-value: 1.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 530404461   606 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQH 639
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 443-685 3.49e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.18  E-value: 3.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 443 NYDLALKYFQKAAEQ--GWVDGQLQLGSMYYNgigvKRDYKQALKYFN--LASQGGHILAFYNLAQMHASgTGVMRScht 518
Cdd:COG2956   23 QPDKAIDLLEEALELdpETVEAHLALGNLYRR----RGEYDRAIRIHQklLERDPDRAEALLELAQDYLK-AGLLDR--- 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 519 AVELFKNVCERGRWSE----RLMTAYnsYKDGDYNAAviqyLLLAEQGYEVAQSNAAFILDQreASIVGENETYPRALLH 594
Cdd:COG2956   95 AEELLEKLLELDPDDAealrLLAEIY--EQEGDWEKA----IEVLERLLKLGPENAHAYCEL--AELYLEQGDYDEAIEA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530404461 595 WNRA--ASQGYTVARIKLGDYHFYGFgtdvDYETAFIHYRLASEQQH-SAQAMFNLGYMHEKgLGIKQDihlAKRFYDMA 671
Cdd:COG2956  167 LEKAlkLDPDCARALLLLAELYLEQG----DYEEAIAALERALEQDPdYLPALPRLAELYEK-LGDPEE---ALELLRKA 238

                        250
                 ....*....|....
gi 530404461 672 AEASPDAQVPVFLA 685
Cdd:COG2956  239 LELDPSDDLLLALA 252
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 373-423 1.09e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.15  E-value: 1.09e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 530404461   373 VQAQVGLGQLHLHGgrgveqnhqmysegsDIVPQSNETALHYFKKAADMGN 423
Cdd:smart00671   1 AEAQYNLGQMYEYG---------------LGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 500-530 2.59e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 36.00  E-value: 2.59e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 530404461   500 YNLAQMHASGTGVMRSCHTAVELFKNVCERG 530
Cdd:smart00671   5 YNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 255-290 5.11e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.23  E-value: 5.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530404461   255 PKGQTALGFLYASGLGVNSSQAKALVYYTFGALGGN 290
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 606-637 6.13e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 34.80  E-value: 6.13e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 530404461  606 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQ 637
Cdd:pfam08238   3 AQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH