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Conserved domains on  [gi|530398462|ref|XP_005271770|]
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cilia- and flagella-associated protein 300 isoform X1 [Homo sapiens]

Protein Classification

cilia- and flagella-associated protein 300( domain architecture ID 10633063)

cilia- and flagella-associated protein 300 (CFAP300) is a DUF4498 domain-containing protein that may play a role in outer and inner dynein arm assembly

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CFAP300 pfam14926
Cilia- and flagella-associated protein 300; CFAP300 is a cilia- and flagella-associated ...
14-209 1.70e-110

Cilia- and flagella-associated protein 300; CFAP300 is a cilia- and flagella-associated protein that is essential for assembly of dynein arms. Mutations in the CFAP300 gene (C11orf70) cause defective cilia motility and primary ciliary dyskinesia.


:

Pssm-ID: 464382  Cd Length: 246  Bit Score: 318.80  E-value: 1.70e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530398462   14 FRFLPQKTFQSLSSKEITSRLRQWSMLGRIKAQAFGFDQTFQSYRKDDFVMAFFKDPNVIPNLKLLSdSSGQWIILGTEV 93
Cdd:pfam14926   1 FTHLPDKTFPFLEDKDVKDLLMKWSLLGRIKAQAFSFDQYFQPYQKDDFLLDFFNDPNVRSNLQLLS-SSGQWGPLGSPV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530398462   94 KKIEAINVPCTQLSMSFFHRLYDEDIVRDSGHIVKCLDSFCDPFLISDELRRVLLVEDSEKYEIFSQPDREEFLFCLFKH 173
Cdd:pfam14926  80 SKVEVEPVPCTVTSMDFFDRLYSEGIVRESGHIVKCFDEFYEGFTISDELRKMLLDEDSENYELFSEEDRKEFLFRLFKH 159
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 530398462  174 LCLGGALCQYEDVISPYLETTKLIYKDLVRILLVCA 209
Cdd:pfam14926 160 LVLGGALCQYEDEIQPYLETTKSLYKDLVSVQKDPE 195
 
Name Accession Description Interval E-value
CFAP300 pfam14926
Cilia- and flagella-associated protein 300; CFAP300 is a cilia- and flagella-associated ...
14-209 1.70e-110

Cilia- and flagella-associated protein 300; CFAP300 is a cilia- and flagella-associated protein that is essential for assembly of dynein arms. Mutations in the CFAP300 gene (C11orf70) cause defective cilia motility and primary ciliary dyskinesia.


Pssm-ID: 464382  Cd Length: 246  Bit Score: 318.80  E-value: 1.70e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530398462   14 FRFLPQKTFQSLSSKEITSRLRQWSMLGRIKAQAFGFDQTFQSYRKDDFVMAFFKDPNVIPNLKLLSdSSGQWIILGTEV 93
Cdd:pfam14926   1 FTHLPDKTFPFLEDKDVKDLLMKWSLLGRIKAQAFSFDQYFQPYQKDDFLLDFFNDPNVRSNLQLLS-SSGQWGPLGSPV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530398462   94 KKIEAINVPCTQLSMSFFHRLYDEDIVRDSGHIVKCLDSFCDPFLISDELRRVLLVEDSEKYEIFSQPDREEFLFCLFKH 173
Cdd:pfam14926  80 SKVEVEPVPCTVTSMDFFDRLYSEGIVRESGHIVKCFDEFYEGFTISDELRKMLLDEDSENYELFSEEDRKEFLFRLFKH 159
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 530398462  174 LCLGGALCQYEDVISPYLETTKLIYKDLVRILLVCA 209
Cdd:pfam14926 160 LVLGGALCQYEDEIQPYLETTKSLYKDLVSVQKDPE 195
 
Name Accession Description Interval E-value
CFAP300 pfam14926
Cilia- and flagella-associated protein 300; CFAP300 is a cilia- and flagella-associated ...
14-209 1.70e-110

Cilia- and flagella-associated protein 300; CFAP300 is a cilia- and flagella-associated protein that is essential for assembly of dynein arms. Mutations in the CFAP300 gene (C11orf70) cause defective cilia motility and primary ciliary dyskinesia.


Pssm-ID: 464382  Cd Length: 246  Bit Score: 318.80  E-value: 1.70e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530398462   14 FRFLPQKTFQSLSSKEITSRLRQWSMLGRIKAQAFGFDQTFQSYRKDDFVMAFFKDPNVIPNLKLLSdSSGQWIILGTEV 93
Cdd:pfam14926   1 FTHLPDKTFPFLEDKDVKDLLMKWSLLGRIKAQAFSFDQYFQPYQKDDFLLDFFNDPNVRSNLQLLS-SSGQWGPLGSPV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530398462   94 KKIEAINVPCTQLSMSFFHRLYDEDIVRDSGHIVKCLDSFCDPFLISDELRRVLLVEDSEKYEIFSQPDREEFLFCLFKH 173
Cdd:pfam14926  80 SKVEVEPVPCTVTSMDFFDRLYSEGIVRESGHIVKCFDEFYEGFTISDELRKMLLDEDSENYELFSEEDRKEFLFRLFKH 159
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 530398462  174 LCLGGALCQYEDVISPYLETTKLIYKDLVRILLVCA 209
Cdd:pfam14926 160 LVLGGALCQYEDEIQPYLETTKSLYKDLVSVQKDPE 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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