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Conserved domains on  [gi|564328444|ref|XP_006229289|]
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secretion-regulating guanine nucleotide exchange factor isoform X2 [Rattus norvegicus]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 13421108)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Mus musculus secretion-regulating guanine nucleotide exchange factor (GEF), which may be involved in the secretion process

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 17-403 7.79e-50

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 173.24  E-value: 7.79e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444  17 LFAWGANSYGQLGLGHKEDVLLPQQLSDFCKsgcIKSVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICK 96
Cdd:COG5184   19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN---VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444  97 PLLGcpIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKcVVPQAIECLREKVVCVAAGLRHALATTDTGSTFQ 176
Cdd:COG5184   96 GLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVDAGLSGVVAIAAGGYHTCALKSDGTVWC 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444 177 WG------TGLASSGRRLcpgqnlplfltakEPSRVTGLesSTVVCAVAGSDHSASLTDTGELYVWGRNKHGQLASLATF 250
Cdd:COG5184  173 WGansygqLGDGTTTDRP-------------TPVQVGGL--SGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTT 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444 251 -LPLPQRVEAhyfqDEKVTAVWSGWTHLVaktgnfrapwtgmlcffsvnrgprgALTTSetGKVFTWGRADYGQLGRtlg 329
Cdd:COG5184  238 dRATPVQVAG----LTGVVAIAAGGSHTC-------------------------ALKSD--GTVWCWGDNSYGQLGD--- 283

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564328444 330 speaqkhGEQDSSLAFQRLQNsvpsplhcLTGAAEVSCGSEHNLAVIRD---KCcsWGWNEHGMCGDGTESNVWTPT 403
Cdd:COG5184  284 -------GTTTDRSTPVKVPG--------LSGVVAVAAGSSHTCALLTDgtvWC--WGDNAYGQLGDGTTTDRSTPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
382-427 5.08e-08

Regulator of chromosome condensation (RCC1) repeat;


:

Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 49.05  E-value: 5.08e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 564328444  382 SWGWNEHGMCGDGTESNVWTPTPVQALPSpSRLLLVGCGAGHSLAL 427
Cdd:pfam00415   6 TWGRNDYGQLGLGTTENVLVPQKVEGLSG-NKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 17-403 7.79e-50

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 173.24  E-value: 7.79e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444  17 LFAWGANSYGQLGLGHKEDVLLPQQLSDFCKsgcIKSVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICK 96
Cdd:COG5184   19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN---VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444  97 PLLGcpIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKcVVPQAIECLREKVVCVAAGLRHALATTDTGSTFQ 176
Cdd:COG5184   96 GLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVDAGLSGVVAIAAGGYHTCALKSDGTVWC 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444 177 WG------TGLASSGRRLcpgqnlplfltakEPSRVTGLesSTVVCAVAGSDHSASLTDTGELYVWGRNKHGQLASLATF 250
Cdd:COG5184  173 WGansygqLGDGTTTDRP-------------TPVQVGGL--SGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTT 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444 251 -LPLPQRVEAhyfqDEKVTAVWSGWTHLVaktgnfrapwtgmlcffsvnrgprgALTTSetGKVFTWGRADYGQLGRtlg 329
Cdd:COG5184  238 dRATPVQVAG----LTGVVAIAAGGSHTC-------------------------ALKSD--GTVWCWGDNSYGQLGD--- 283

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564328444 330 speaqkhGEQDSSLAFQRLQNsvpsplhcLTGAAEVSCGSEHNLAVIRD---KCcsWGWNEHGMCGDGTESNVWTPT 403
Cdd:COG5184  284 -------GTTTDRSTPVKVPG--------LSGVVAVAAGSSHTCALLTDgtvWC--WGDNAYGQLGDGTTTDRSTPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
17-64 9.29e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 56.76  E-value: 9.29e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 564328444   17 LFAWGANSYGQLGLGHKEDVLLPQQLSdFCKSGCIKSVTGGGGHSVVV 64
Cdd:pfam00415   4 VYTWGRNDYGQLGLGTTENVLVPQKVE-GLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
382-427 5.08e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 49.05  E-value: 5.08e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 564328444  382 SWGWNEHGMCGDGTESNVWTPTPVQALPSpSRLLLVGCGAGHSLAL 427
Cdd:pfam00415   6 TWGRNDYGQLGLGTTENVLVPQKVEGLSG-NKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 17-403 7.79e-50

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 173.24  E-value: 7.79e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444  17 LFAWGANSYGQLGLGHKEDVLLPQQLSDFCKsgcIKSVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICK 96
Cdd:COG5184   19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN---VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444  97 PLLGcpIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKcVVPQAIECLREKVVCVAAGLRHALATTDTGSTFQ 176
Cdd:COG5184   96 GLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVDAGLSGVVAIAAGGYHTCALKSDGTVWC 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444 177 WG------TGLASSGRRLcpgqnlplfltakEPSRVTGLesSTVVCAVAGSDHSASLTDTGELYVWGRNKHGQLASLATF 250
Cdd:COG5184  173 WGansygqLGDGTTTDRP-------------TPVQVGGL--SGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTT 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444 251 -LPLPQRVEAhyfqDEKVTAVWSGWTHLVaktgnfrapwtgmlcffsvnrgprgALTTSetGKVFTWGRADYGQLGRtlg 329
Cdd:COG5184  238 dRATPVQVAG----LTGVVAIAAGGSHTC-------------------------ALKSD--GTVWCWGDNSYGQLGD--- 283

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564328444 330 speaqkhGEQDSSLAFQRLQNsvpsplhcLTGAAEVSCGSEHNLAVIRD---KCcsWGWNEHGMCGDGTESNVWTPT 403
Cdd:COG5184  284 -------GTTTDRSTPVKVPG--------LSGVVAVAAGSSHTCALLTDgtvWC--WGDNAYGQLGDGTTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 53-427 5.59e-43

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 155.13  E-value: 5.59e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444  53 SVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICKPLLGcpIRQVACGWDFTIMLTEKGQVLSCGSNAFGQ 132
Cdd:COG5184    2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444 133 LGVPhGPRKCVVPQAIECLrEKVVCVAAGLRHALATTDTGSTFQWGT------GLASSGRRLCPGQnlplfltakepsrv 206
Cdd:COG5184   80 LGDG-TTTDRTTPVKVPGL-TGVVAVAAGYYHSCALKSDGTVWCWGDnssgqlGDGTTTNRLTPVQ-------------- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444 207 TGLESSTVVCAVAGSDHSASLTDTGELYVWGRNKHGQLASLATF-LPLPQRVEAHyfqdEKVTAVWSGWTHLVAKTGNfr 285
Cdd:COG5184  144 VDAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTdRPTPVQVGGL----SGVVAVAAGGDHSCALKSD-- 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444 286 apwtgmlcffsvnrgprgalttsetGKVFTWGRADYGQLGrtLGSPEAQkhgeqdsslafqrlqnSVPSPLHCLTGAAEV 365
Cdd:COG5184  218 -------------------------GTVWCWGSNSSGQLG--DGTTTDR----------------ATPVQVAGLTGVVAI 254

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564328444 366 SCGSEHNLAVIRD---KCcsWGWNEHGMCGDGTESNVWTPTPVQALPSPSRlllVGCGAGHSLAL 427
Cdd:COG5184  255 AAGGSHTCALKSDgtvWC--WGDNSYGQLGDGTTTDRSTPVKVPGLSGVVA---VAAGSSHTCAL 314
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 104-427 1.05e-34

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 132.79  E-value: 1.05e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444 104 RQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKcVVPQAIECLrEKVVCVAAGLRHALATTDTGSTFQWGTGlaS 183
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDR-STPVRVPGL-SNVVAVAAGGDHTCALKADGTVWCWGNN--S 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444 184 SGrRLCPGQNLPlfltAKEPSRVTGLesSTVVCAVAGSDHSASLTDTGELYVWGRNKHGQLASLATFLPL-PQRVEAhyf 262
Cdd:COG5184   77 YG-QLGDGTTTD----RTTPVKVPGL--TGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLtPVQVDA--- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444 263 QDEKVTAVWSGWTHlvaktgnfrapwtgmlcffsvnrgprgALTTSETGKVFTWGRADYGQLGrtLGSPEAQkhgeqdss 342
Cdd:COG5184  147 GLSGVVAIAAGGYH---------------------------TCALKSDGTVWCWGANSYGQLG--DGTTTDR-------- 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328444 343 lafqrlqnSVPSPLHCLTGAAEVSCGSEHNLAVIRD---KCcsWGWNEHGMCGDGTESNVWTPTPVQALPSPSRlllVGC 419
Cdd:COG5184  190 --------PTPVQVGGLSGVVAVAAGGDHSCALKSDgtvWC--WGSNSSGQLGDGTTTDRATPVQVAGLTGVVA---IAA 256


                 ....*...
gi 564328444 420 GAGHSLAL 427
Cdd:COG5184  257 GGSHTCAL 264
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
17-64 9.29e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 56.76  E-value: 9.29e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 564328444   17 LFAWGANSYGQLGLGHKEDVLLPQQLSdFCKSGCIKSVTGGGGHSVVV 64
Cdd:pfam00415   4 VYTWGRNDYGQLGLGTTENVLVPQKVE-GLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
68-116 3.64e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 49.44  E-value: 3.64e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 564328444   68 GGLFVCGLNKDGQLGLGHTEEVLRFTICKPLLGCPIRQVACGWDFTIML 116
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
382-427 5.08e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 49.05  E-value: 5.08e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 564328444  382 SWGWNEHGMCGDGTESNVWTPTPVQALPSpSRLLLVGCGAGHSLAL 427
Cdd:pfam00415   6 TWGRNDYGQLGLGTTENVLVPQKVEGLSG-NKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
103-132 1.09e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 47.80  E-value: 1.09e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 564328444  103 IRQVACGWDFTIMLTEKGQVLSCGSNAFGQ 132
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
214-243 2.14e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.95  E-value: 2.14e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 564328444  214 VVCAVAGSDHSASLTDTGELYVWGRNKHGQ 243
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
119-167 5.28e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 40.58  E-value: 5.28e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 564328444  119 KGQVLSCGSNAFGQLGvpHGPRKCV-VPQAIECLRE-KVVCVAAGLRHALA 167
Cdd:pfam00415   1 DGRVYTWGRNDYGQLG--LGTTENVlVPQKVEGLSGnKVVQVACGGDHTVA 49
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
311-375 6.56e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 40.19  E-value: 6.56e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564328444  311 GKVFTWGRADYGQLGrtlgspeaqkHGEQDSSLAFQRLQNSVPSPlhcltgAAEVSCGSEHNLAV 375
Cdd:pfam00415   2 GRVYTWGRNDYGQLG----------LGTTENVLVPQKVEGLSGNK------VVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
51-80 2.03e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 38.56  E-value: 2.03e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 564328444   51 IKSVTGGGGHSVVVTDGGGLFVCGLNKDGQ 80
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
231-279 8.47e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 37.11  E-value: 8.47e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 564328444  231 GELYVWGRNKHGQLASLATFL-PLPQRVEAhyFQDEKVTAVWSGWTHLVA 279
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENvLVPQKVEG--LSGNKVVQVACGGDHTVA 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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