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Conserved domains on  [gi|564328449|ref|XP_006229291|]
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secretion-regulating guanine nucleotide exchange factor isoform X7 [Rattus norvegicus]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 17-347 2.48e-51

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 175.17  E-value: 2.48e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449  17 LFAWGANSYGQLGLGHKEDVLLPQQLSDFCKsgcIKSVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICK 96
Cdd:COG5184   19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN---VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449  97 PLLGcpIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKcVVPQAIECLREKVVCVAAGLRHALATTDTGSTFQ 176
Cdd:COG5184   96 GLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVDAGLSGVVAIAAGGYHTCALKSDGTVWC 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449 177 WG------TGLASSGRRLcpgqnlplfltakEPSRVTGLesSTVVCAVAGSDHSASLTETGKVFTWGRADYGQLGrtLGS 250
Cdd:COG5184  173 WGansygqLGDGTTTDRP-------------TPVQVGGL--SGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLG--DGT 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449 251 PEAQkhgeqdsslafqrlqnSVPSPLHCLTGAAEVSCGSEHNLAVIRD---KCcsWGWNEHGMCGDGTESNVWTPTPVQA 327
Cdd:COG5184  236 TTDR----------------ATPVQVAGLTGVVAIAAGGSHTCALKSDgtvWC--WGDNSYGQLGDGTTTDRSTPVKVPG 297

                        330       340
                 ....*....|....*....|
gi 564328449 328 LPSPSRlllVGCGAGHSLAL 347
Cdd:COG5184  298 LSGVVA---VAAGSSHTCAL 314
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 17-347 2.48e-51

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 175.17  E-value: 2.48e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449  17 LFAWGANSYGQLGLGHKEDVLLPQQLSDFCKsgcIKSVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICK 96
Cdd:COG5184   19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN---VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449  97 PLLGcpIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKcVVPQAIECLREKVVCVAAGLRHALATTDTGSTFQ 176
Cdd:COG5184   96 GLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVDAGLSGVVAIAAGGYHTCALKSDGTVWC 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449 177 WG------TGLASSGRRLcpgqnlplfltakEPSRVTGLesSTVVCAVAGSDHSASLTETGKVFTWGRADYGQLGrtLGS 250
Cdd:COG5184  173 WGansygqLGDGTTTDRP-------------TPVQVGGL--SGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLG--DGT 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449 251 PEAQkhgeqdsslafqrlqnSVPSPLHCLTGAAEVSCGSEHNLAVIRD---KCcsWGWNEHGMCGDGTESNVWTPTPVQA 327
Cdd:COG5184  236 TTDR----------------ATPVQVAGLTGVVAIAAGGSHTCALKSDgtvWC--WGDNSYGQLGDGTTTDRSTPVKVPG 297

                        330       340
                 ....*....|....*....|
gi 564328449 328 LPSPSRlllVGCGAGHSLAL 347
Cdd:COG5184  298 LSGVVA---VAAGSSHTCAL 314
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
17-64 1.00e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 56.37  E-value: 1.00e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 564328449   17 LFAWGANSYGQLGLGHKEDVLLPQQLSdFCKSGCIKSVTGGGGHSVVV 64
Cdd:pfam00415   4 VYTWGRNDYGQLGLGTTENVLVPQKVE-GLSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 17-347 2.48e-51

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 175.17  E-value: 2.48e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449  17 LFAWGANSYGQLGLGHKEDVLLPQQLSDFCKsgcIKSVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICK 96
Cdd:COG5184   19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN---VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVP 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449  97 PLLGcpIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKcVVPQAIECLREKVVCVAAGLRHALATTDTGSTFQ 176
Cdd:COG5184   96 GLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNR-LTPVQVDAGLSGVVAIAAGGYHTCALKSDGTVWC 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449 177 WG------TGLASSGRRLcpgqnlplfltakEPSRVTGLesSTVVCAVAGSDHSASLTETGKVFTWGRADYGQLGrtLGS 250
Cdd:COG5184  173 WGansygqLGDGTTTDRP-------------TPVQVGGL--SGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLG--DGT 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449 251 PEAQkhgeqdsslafqrlqnSVPSPLHCLTGAAEVSCGSEHNLAVIRD---KCcsWGWNEHGMCGDGTESNVWTPTPVQA 327
Cdd:COG5184  236 TTDR----------------ATPVQVAGLTGVVAIAAGGSHTCALKSDgtvWC--WGDNSYGQLGDGTTTDRSTPVKVPG 297

                        330       340
                 ....*....|....*....|
gi 564328449 328 LPSPSRlllVGCGAGHSLAL 347
Cdd:COG5184  298 LSGVVA---VAAGSSHTCAL 314
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 17-323 9.91e-47

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 163.22  E-value: 9.91e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449  17 LFAWGANSYGQLGLGHKEDVLLPQQLSDFcksGCIKSVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICK 96
Cdd:COG5184   69 VWCWGNNSYGQLGDGTTTDRTTPVKVPGL---TGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVD 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449  97 PLLGcPIRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKcVVPQAIECLREkVVCVAAGLRHALATTDTGSTFQ 176
Cdd:COG5184  146 AGLS-GVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDR-PTPVQVGGLSG-VVAVAAGGDHSCALKSDGTVWC 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449 177 WGTGlaSSGRrLCPGQNLPLFLtakePSRVTGLesSTVVCAVAGSDHSASLTETGKVFTWGRADYGQLGRtlgspeaqkh 256
Cdd:COG5184  223 WGSN--SSGQ-LGDGTTTDRAT----PVQVAGL--TGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGD---------- 283

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449 257 GEQDSSLAFQRLQNsvpsplhcLTGAAEVSCGSEHNLAVIRD---KCcsWGWNEHGMCGDGTESNVWTPT 323
Cdd:COG5184  284 GTTTDRSTPVKVPG--------LSGVVAVAAGSSHTCALLTDgtvWC--WGDNAYGQLGDGTTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 53-347 4.31e-38

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 140.11  E-value: 4.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449  53 SVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICKPLLGcpIRQVACGWDFTIMLTEKGQVLSCGSNAFGQ 132
Cdd:COG5184    2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449 133 LGVPhGPRKCVVPQAIECLrEKVVCVAAGLRHALATTDTGSTFQWGT------GLASSGRRLCPGQnlplfltakepsrv 206
Cdd:COG5184   80 LGDG-TTTDRTTPVKVPGL-TGVVAVAAGYYHSCALKSDGTVWCWGDnssgqlGDGTTTNRLTPVQ-------------- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449 207 TGLESSTVVCAVAGSDHSASLTETGKVFTWGRADYGQLGrtLGSPEAQkhgeqdsslafqrlqnSVPSPLHCLTGAAEVS 286
Cdd:COG5184  144 VDAGLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLG--DGTTTDR----------------PTPVQVGGLSGVVAVA 205

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564328449 287 CGSEHNLAVIRD---KCcsWGWNEHGMCGDGTESNVWTPTPVQALPSPSRlllVGCGAGHSLAL 347
Cdd:COG5184  206 AGGDHSCALKSDgtvWC--WGSNSSGQLGDGTTTDRATPVQVAGLTGVVA---IAAGGSHTCAL 264
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 104-347 8.65e-28

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 111.99  E-value: 8.65e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449 104 RQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKcVVPQAIECLrEKVVCVAAGLRHALATTDTGSTFQWGTGlaS 183
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDR-STPVRVPGL-SNVVAVAAGGDHTCALKADGTVWCWGNN--S 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449 184 SGrRLCPGQNLPlfltAKEPSRVTGLesSTVVCAVAGSDHSASLTETGKVFTWGRADYGQLGRtlgspeaqkhGEQDSSL 263
Cdd:COG5184   77 YG-QLGDGTTTD----RTTPVKVPGL--TGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD----------GTTTNRL 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564328449 264 AFQRLQNSvpsplhcLTGAAEVSCGSEHNLAVIRD---KCcsWGWNEHGMCGDGTESNVWTPTPVQALPSPSRlllVGCG 340
Cdd:COG5184  140 TPVQVDAG-------LSGVVAIAAGGYHTCALKSDgtvWC--WGANSYGQLGDGTTTDRPTPVQVGGLSGVVA---VAAG 207


                 ....*..
gi 564328449 341 AGHSLAL 347
Cdd:COG5184  208 GDHSCAL 214
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
17-64 1.00e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 56.37  E-value: 1.00e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 564328449   17 LFAWGANSYGQLGLGHKEDVLLPQQLSdFCKSGCIKSVTGGGGHSVVV 64
Cdd:pfam00415   4 VYTWGRNDYGQLGLGTTENVLVPQKVE-GLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
68-116 3.60e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 49.44  E-value: 3.60e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 564328449   68 GGLFVCGLNKDGQLGLGHTEEVLRFTICKPLLGCPIRQVACGWDFTIML 116
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
302-347 5.18e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 49.05  E-value: 5.18e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 564328449  302 SWGWNEHGMCGDGTESNVWTPTPVQALPSpSRLLLVGCGAGHSLAL 347
Cdd:pfam00415   6 TWGRNDYGQLGLGTTENVLVPQKVEGLSG-NKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
103-132 1.07e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 47.42  E-value: 1.07e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 564328449  103 IRQVACGWDFTIMLTEKGQVLSCGSNAFGQ 132
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
214-243 4.77e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 40.10  E-value: 4.77e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 564328449  214 VVCAVAGSDHSASLTETGKVFTWGRADYGQ 243
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
119-167 5.60e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 40.19  E-value: 5.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 564328449  119 KGQVLSCGSNAFGQLGvpHGPRKCV-VPQAIECLRE-KVVCVAAGLRHALA 167
Cdd:pfam00415   1 DGRVYTWGRNDYGQLG--LGTTENVlVPQKVEGLSGnKVVQVACGGDHTVA 49
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
231-295 6.75e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 40.19  E-value: 6.75e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564328449  231 GKVFTWGRADYGQLGrtlgspeaqkHGEQDSSLAFQRLQNSVPSPlhcltgAAEVSCGSEHNLAV 295
Cdd:pfam00415   2 GRVYTWGRNDYGQLG----------LGTTENVLVPQKVEGLSGNK------VVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
51-80 1.94e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 38.17  E-value: 1.94e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 564328449   51 IKSVTGGGGHSVVVTDGGGLFVCGLNKDGQ 80
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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