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Conserved domains on  [gi|564341870|ref|XP_006234619|]
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rho GTPase-activating protein 1 isoform X1 [Rattus norvegicus]

Protein Classification

SEC14 and RhoGAP-p50rhoGAP domain-containing protein( domain architecture ID 10617207)

SEC14 and RhoGAP-p50rhoGAP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 239-431 2.18e-119

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 346.25  E-value: 2.18e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 239 NQQFGVSLQHLREKNPNQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVIL 318
Cdd:cd04404    3 TQQFGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVIL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 319 KTFLRELPEPLLTFDLYPHIVGFLDLDDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGP 398
Cdd:cd04404   83 KTFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGP 162

                        170       180       190
                 ....*....|....*....|....*....|...
gi 564341870 399 NLLWAKDAAITLKAINPINTFTKFLLDHQGELF 431
Cdd:cd04404  163 NLLWAKDASMSLSAINPINTFTKFLLDHQDEIF 195
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 82-216 1.16e-30

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


:

Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 115.12  E-value: 1.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870   82 GRKIIVFSACRMP--PSHQLDHSKLLGYLKHTLDQYVES-DYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKAL 158
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLSEKLKGkPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRAFKKNLKAV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564341870  159 YIVHPTMFIKTLL-ILFKPLISFKFGRKIFYVNYLSELSEHVKLEQL--GIPrQVLKYDDF 216
Cdd:pfam13716  81 YVVHPSTFLRTFLkTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLptELP-GVLSYDEE 140
 
Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 239-431 2.18e-119

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 346.25  E-value: 2.18e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 239 NQQFGVSLQHLREKNPNQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVIL 318
Cdd:cd04404    3 TQQFGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVIL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 319 KTFLRELPEPLLTFDLYPHIVGFLDLDDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGP 398
Cdd:cd04404   83 KTFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGP 162

                        170       180       190
                 ....*....|....*....|....*....|...
gi 564341870 399 NLLWAKDAAITLKAINPINTFTKFLLDHQGELF 431
Cdd:cd04404  163 NLLWAKDASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 258-427 1.65e-50

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 168.60  E-value: 1.65e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870   258 PIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFD-QYNELHLPAVILKTFLRELPEPLLTFDLYP 336
Cdd:smart00324   2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDlSEYDVHDVAGLLKLFLRELPEPLITYELYE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870   337 H-IVGFLDLDDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPNLLWAKD-AAITLKAIN 414
Cdd:smart00324  82 EfIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDgEVASLKDIR 161

                          170
                   ....*....|...
gi 564341870   415 PINTFTKFLLDHQ 427
Cdd:smart00324 162 HQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 260-405 3.13e-50

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 166.95  E-value: 3.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870  260 PIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMG-LPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHI 338
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGpDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564341870  339 VGFLDL-DDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPNLLWAKD 405
Cdd:pfam00620  81 IEAAKLpDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 82-216 1.16e-30

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 115.12  E-value: 1.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870   82 GRKIIVFSACRMP--PSHQLDHSKLLGYLKHTLDQYVES-DYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKAL 158
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLSEKLKGkPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRAFKKNLKAV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564341870  159 YIVHPTMFIKTLL-ILFKPLISFKFGRKIFYVNYLSELSEHVKLEQL--GIPrQVLKYDDF 216
Cdd:pfam13716  81 YVVHPSTFLRTFLkTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLptELP-GVLSYDEE 140
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 66-215 1.05e-24

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 99.30  E-value: 1.05e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870    66 DIARHQIVEVAGDDKYGRKIIVFSACRMPPsHQLDHSKLLGYLKHTLDQYVES---DYTLLYLHHGLTSDNKPS----LS 138
Cdd:smart00516   3 ELLKAYIPGGRGYDKDGRPVLIERAGRFDL-KSVTLEELLRYLVYVLEKILQEekkTGGIEGFTVIFDLKGLSMsnpdLS 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564341870   139 WLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGRKIFYV--NYLSELSEHVKLEQLgiPRQVLKYDD 215
Cdd:smart00516  82 VLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVgnDSKEELLEYIDKEQL--PEELGGTLD 158
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 77-204 1.82e-22

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 93.17  E-value: 1.82e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870  77 GDDKYGRKIIVFSAcRMPPSHQLDHSKLLGYLKHTLDQYVESDY------TLLYLHHGLTSDNKPSLSWLRDAYREFDRK 150
Cdd:cd00170   16 GRDKEGRPVLVFRA-GWDPPKLLDLEELLRYLVYLLEKALRELEeqvegfVVIIDLKGFSLSNLSDLSLLKKLLKILQDH 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564341870 151 YKKNIKALYIVHPTMFIKTLLILFKPLISFKFGRKIFYVNY-LSELSEHVKLEQL 204
Cdd:cd00170   95 YPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSdLEELLEYIDPDQL 149
 
Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 239-431 2.18e-119

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 346.25  E-value: 2.18e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 239 NQQFGVSLQHLREKNPNQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVIL 318
Cdd:cd04404    3 TQQFGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVIL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 319 KTFLRELPEPLLTFDLYPHIVGFLDLDDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGP 398
Cdd:cd04404   83 KTFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGP 162

                        170       180       190
                 ....*....|....*....|....*....|...
gi 564341870 399 NLLWAKDAAITLKAINPINTFTKFLLDHQGELF 431
Cdd:cd04404  163 NLLWAKDASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 258-427 1.65e-50

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 168.60  E-value: 1.65e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870   258 PIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFD-QYNELHLPAVILKTFLRELPEPLLTFDLYP 336
Cdd:smart00324   2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDlSEYDVHDVAGLLKLFLRELPEPLITYELYE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870   337 H-IVGFLDLDDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPNLLWAKD-AAITLKAIN 414
Cdd:smart00324  82 EfIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDgEVASLKDIR 161

                          170
                   ....*....|...
gi 564341870   415 PINTFTKFLLDHQ 427
Cdd:smart00324 162 HQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 260-405 3.13e-50

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 166.95  E-value: 3.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870  260 PIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMG-LPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHI 338
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGpDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564341870  339 VGFLDL-DDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPNLLWAKD 405
Cdd:pfam00620  81 IEAAKLpDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 260-426 3.87e-50

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 167.48  E-value: 3.87e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 260 PIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHIV 339
Cdd:cd00159    1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 340 G-FLDLDDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPNLLWAKDAAITLKA-INPIN 417
Cdd:cd00159   81 ElAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDELLEdIKKLN 160


                 ....*....
gi 564341870 418 TFTKFLLDH 426
Cdd:cd00159  161 EIVEFLIEN 169
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-425 6.25e-36

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 131.05  E-value: 6.25e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREKNPNQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTF 321
Cdd:cd04393    3 FGVPLQELQQAGQPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLRLF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 322 LRELPEPLLTFDLYPHIVG-FLDLD-DDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPN 399
Cdd:cd04393   83 LQELPEGLIPASLQIRLMQlYQDYNgEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAVFGPD 162

                        170       180
                 ....*....|....*....|....*.
gi 564341870 400 LLWAKDAAITLKAINPINTFTKFLLD 425
Cdd:cd04393  163 VFHVYTDVEDMKEQEICSRIMAKLLE 188
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 240-432 6.59e-36

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 131.43  E-value: 6.59e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 240 QQFGVSLQ-HLREKNpnqEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMG---LPVDfDQYNELHLPA 315
Cdd:cd04386    3 PVFGTPLEeHLKRTG---REIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtfsLPLD-EFYSDPHAVA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 316 VILKTFLRELPEPLLTFDLYPHIVGFLDL-DDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAV 394
Cdd:cd04386   79 SALKSYLRELPDPLLTYNLYEDWVQAANKpDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAI 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 564341870 395 VFGPNLLWAK-DAAITLKAINP---INTFTKFLLDHQGELFP 432
Cdd:cd04386  159 VLAPNLLWAKnEGSLAEMAAGTsvhVVAIVELIISHADWFFP 200
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-431 4.28e-34

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 125.87  E-value: 4.28e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREKNPNQEPIpivlRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNeLHLPAVILKTF 321
Cdd:cd04402    2 FGQPLSNICEDDNLPKPI----LDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEP-VLLLASVLKDF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 322 LRELPEPLLTFDLYPHIVGFLDLDD-DQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPNL 400
Cdd:cd04402   77 LRNIPGSLLSSDLYEEWMSALDQENeEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSL 156

                        170       180       190
                 ....*....|....*....|....*....|...
gi 564341870 401 LWaKDAAITLKA--INPINTFTKFLLDHQGELF 431
Cdd:cd04402  157 LW-PPASSELQNedLKKVTSLVQFLIENCQEIF 188
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 242-420 6.51e-31

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 117.15  E-value: 6.51e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREknpNQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGL-PVDFDQYNeLHLPAVILKT 320
Cdd:cd04377    1 FGVSLSSLTS---EDRSVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPdSVNLEDYP-IHVITSVLKQ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 321 FLRELPEPLLTFDLYPHIVGFLDLDDDQ-RVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPN 399
Cdd:cd04377   77 WLRELPEPLMTFELYENFLRAMELEEKQeRVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFAPC 156

                        170       180
                 ....*....|....*....|.
gi 564341870 400 LLWAKDAAITLKAINPINTFT 420
Cdd:cd04377  157 ILRCPDTADPLQSLQDVSKTT 177
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 82-216 1.16e-30

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 115.12  E-value: 1.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870   82 GRKIIVFSACRMP--PSHQLDHSKLLGYLKHTLDQYVES-DYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKAL 158
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLSEKLKGkPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRAFKKNLKAV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564341870  159 YIVHPTMFIKTLL-ILFKPLISFKFGRKIFYVNYLSELSEHVKLEQL--GIPrQVLKYDDF 216
Cdd:pfam13716  81 YVVHPSTFLRTFLkTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLptELP-GVLSYDEE 140
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 253-401 5.52e-28

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 109.84  E-value: 5.52e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 253 NPNQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTF 332
Cdd:cd04376    3 NPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 333 DLYPHIVGFLDLDDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQ-----------NRMNNTNLAVVFGPNLL 401
Cdd:cd04376   83 ELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADsidedgqevsgNKMTSLNLATIFGPNLL 162
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 242-431 1.05e-26

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 106.37  E-value: 1.05e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQH--LREKNPNQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILK 319
Cdd:cd04390    3 FGQRLEDtvAYERKFGPRLVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLLK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 320 TFLRELPEPLLTFDLYPhivGFLD----LDDDQ---RVEVTQQVlQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNL 392
Cdd:cd04390   83 LYLRELPEPVIPWAQYE---DFLScaqlLSKDEekgLGELMKQV-SILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 564341870 393 AVVFGPNLLWAK--DAAITLKAINPINTFTKFLLDHQGELF 431
Cdd:cd04390  159 ATVFGPNILRPKveDPATIMEGTPQIQQLMTVMISKHEPLF 199
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 242-425 1.14e-25

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 103.21  E-value: 1.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSL-QHLREKNP--NQEPIPIVLRETVAYL-QAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNE---LHLP 314
Cdd:cd04400    2 FGSPLeEAVELSSHkyNGRDLPSVVYRCIEYLdKNRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSLypdVHTV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 315 AVILKTFLRELPEPLLTFDLYPHIVGFLDL--DDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNL 392
Cdd:cd04400   82 AGLLKLYLRELPTLILGGELHNDFKRLVEEnhDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRNV 161

                        170       180       190
                 ....*....|....*....|....*....|...
gi 564341870 393 AVVFGPNLlwakdaAItlkainPINTFTKFLLD 425
Cdd:cd04400  162 CIVFSPTL------NI------PAGIFVLFLTD 182
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-401 1.37e-25

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 103.32  E-value: 1.37e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREKN-PNQEPIPIVLRETVAYLQAHaLTAEGIFRRSANTQVVREVQQKYNMG-------LPVDFdqynelhl 313
Cdd:cd04394    2 FGVPLHSLPHSTvPEYGNVPKFLVDACTFLLDH-LSTEGLFRKSGSVVRQKELKAKLEGGeaclssaLPCDV-------- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 314 pAVILKTFLRELPEPLLTFDLYPHIVGFLDLD-DDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNL 392
Cdd:cd04394   73 -AGLLKQFFRELPEPLLPYDLHEALLKAQELPtDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNL 151


                 ....*....
gi 564341870 393 AVVFGPNLL 401
Cdd:cd04394  152 AVIFAPNLF 160
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 242-401 1.76e-25

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 102.47  E-value: 1.76e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHL--REKNPnqepIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFD--QYNELHLPAVI 317
Cdd:cd04403    1 FGCHLEALcqRENST----VPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLDdsKWEDIHVITGA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 318 LKTFLRELPEPLLTFDLYPHIVGFLDLDD-DQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVF 396
Cdd:cd04403   77 LKLFFRELPEPLFPYSLFNDFVAAIKLSDyEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVF 156


                 ....*
gi 564341870 397 GPNLL 401
Cdd:cd04403  157 GPTLL 161
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 242-424 3.58e-25

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 101.61  E-value: 3.58e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREknpNQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGlP--VDFDQYnELHLPAVILK 319
Cdd:cd04407    1 FGVRVGSLTS---NKTSVPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQAD-PenVKLENY-PIHAITGLLK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 320 TFLRELPEPLLTFDLYPHIVGFLDLDDDQ-RVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGP 398
Cdd:cd04407   76 QWLRELPEPLMTFAQYNDFLRAVELPEKQeQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAP 155

                        170       180
                 ....*....|....*....|....*....
gi 564341870 399 NLLWAKDAA---ITLKAINPINTFTKFLL 424
Cdd:cd04407  156 CLLRCPDSSdplTSMKDVAKTTTCVEMLI 184
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-401 6.05e-25

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 101.33  E-value: 6.05e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREKNpnQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQ-------KYNMGLPVDFDqyNELHLP 314
Cdd:cd04398    1 FGVPLEDLILRE--GDNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKElfdkdplNVLLISPEDYE--SDIHSV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 315 AVILKTFLRELPEPLLTFDLYPHIVGFLDLDDD-QRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLA 393
Cdd:cd04398   77 ASLLKLFFRELPEPLLTKALSREFIEAAKIEDEsRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLA 156


                 ....*...
gi 564341870 394 VVFGPNLL 401
Cdd:cd04398  157 IIWGPTLM 164
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 248-409 7.22e-25

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 100.85  E-value: 7.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 248 HLREKNPNQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKY-NMGLPVDFDQyNELHLPAV--ILKTFLRE 324
Cdd:cd04385    4 ALEDQQLTDNDIPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFrKDARSVQLRE-GEYTVHDVadVLKRFLRD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 325 LPEPLLTFDLYPHIVGFLDL-DDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPNLLWA 403
Cdd:cd04385   83 LPDPLLTSELHAEWIEAAELeNKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQT 162


                 ....*.
gi 564341870 404 KDAAIT 409
Cdd:cd04385  163 DEHSVG 168
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 66-215 1.05e-24

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 99.30  E-value: 1.05e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870    66 DIARHQIVEVAGDDKYGRKIIVFSACRMPPsHQLDHSKLLGYLKHTLDQYVES---DYTLLYLHHGLTSDNKPS----LS 138
Cdd:smart00516   3 ELLKAYIPGGRGYDKDGRPVLIERAGRFDL-KSVTLEELLRYLVYVLEKILQEekkTGGIEGFTVIFDLKGLSMsnpdLS 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564341870   139 WLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGRKIFYV--NYLSELSEHVKLEQLgiPRQVLKYDD 215
Cdd:smart00516  82 VLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVgnDSKEELLEYIDKEQL--PEELGGTLD 158
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-400 2.98e-24

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 99.40  E-value: 2.98e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREKNPNQEpIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMG---LPVDFDQYNELHLPAVIL 318
Cdd:cd04395    2 FGVPLDDCPPSSENPY-VPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGgfdIDLQDPRWRDVNVVSSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 319 KTFLRELPEPLLTFDLYPHivgFLDLD----DDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAV 394
Cdd:cd04395   81 KSFFRKLPEPLFTNELYPD---FIEANriedPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAI 157


                 ....*.
gi 564341870 395 VFGPNL 400
Cdd:cd04395  158 VFGPTL 163
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 242-401 1.34e-23

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 97.88  E-value: 1.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREKNPnqEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLP-VDFDQYNElHLPAVILKT 320
Cdd:cd04378    1 FGVDFSQVPRDFP--DEVPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDlVELSELSP-HDISSVLKL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 321 FLRELPEPLLTFDLYPHIVGFL-----DLDDDQRVEVTQQV----------LQTLPEENYRVLHFLTAFLVQVSAHSYQN 385
Cdd:cd04378   78 FLRQLPEPLILFRLYNDFIALAkeiqrDTEEDKAPNTPIEVnriirklkdlLRQLPASNYNTLQHLIAHLYRVAEQFEEN 157

                        170
                 ....*....|....*.
gi 564341870 386 RMNNTNLAVVFGPNLL 401
Cdd:cd04378  158 KMSPNNLGIVFGPTLI 173
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 257-400 2.63e-23

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 97.49  E-value: 2.63e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 257 EPIPIVLRETVAYLQAHALTAEGIFRRS---ANTQVVREVQQKYNMGlpVDFDQYnELHLPAVILKTFLRELPEPLLTFD 333
Cdd:cd04375   18 QPLPRSIQQAMRWLRNNALDQVGLFRKSgvkSRIQKLRSMIESSTDN--VNYDGQ-QAYDVADMLKQYFRDLPEPLLTNK 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 334 L---YPHIvgFLDLDDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPNL 400
Cdd:cd04375   95 LsetFIAI--FQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLAPSL 162
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-401 3.52e-23

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 95.99  E-value: 3.52e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLrekNPNQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKynmglpvdFDQYNEL---------H 312
Cdd:cd04373    1 FGVPLANV---VTSEKPIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQ--------FDQDHNLdlvskdftvN 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 313 LPAVILKTFLRELPEPLLTFDLYPHIV-GFLDLDDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTN 391
Cdd:cd04373   70 AVAGALKSFFSELPDPLIPYSMHLELVeAAKINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSEN 149

                        170
                 ....*....|
gi 564341870 392 LAVVFGPNLL 401
Cdd:cd04373  150 LSICFWPTLM 159
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 259-430 3.94e-23

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 97.10  E-value: 3.94e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 259 IPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYN----MGLPVDFDQYNeLHLPAVILKTFLRELPEPLLTFDL 334
Cdd:cd04396   32 IPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFStppdYGKSFDWDGYT-VHDAASVLRRYLNNLPEPLVPLDL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 335 Y----------PHIVGF--------LDLDDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVF 396
Cdd:cd04396  111 YeefrnplrkrPRILQYmkgrinepLNTDIDQAIKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIF 190

                        170       180       190
                 ....*....|....*....|....*....|....
gi 564341870 397 GPNLLWAKDAAITLKAINPINTFTKFLLDHQGEL 430
Cdd:cd04396  191 QPGILSHPDHEMDPKEYKLSRLVVEFLIEHQDKF 224
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-430 1.30e-22

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 95.12  E-value: 1.30e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREKN---------PNQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMG--LPVDFDQYNE 310
Cdd:cd04397    1 FGVPLEILVEKFgadstlgvgPGKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNptEVPDLSKENP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 311 LHLpAVILKTFLRELPEPLLTFDLYPHIVGFLDLDD-DQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSY-----Q 384
Cdd:cd04397   81 VQL-AALLKKFLRELPDPLLTFKLYRLWISSQKIEDeEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFSHideetG 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564341870 385 NRMNNTNLAVVFGPNLLWAKDAAITLK-----AINPINTftkfLLDHQGEL 430
Cdd:cd04397  160 SKMDIHNLATVITPNILYSKTDNPNTGdeyflAIEAVNY----LIENNEEF 206
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 77-204 1.82e-22

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 93.17  E-value: 1.82e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870  77 GDDKYGRKIIVFSAcRMPPSHQLDHSKLLGYLKHTLDQYVESDY------TLLYLHHGLTSDNKPSLSWLRDAYREFDRK 150
Cdd:cd00170   16 GRDKEGRPVLVFRA-GWDPPKLLDLEELLRYLVYLLEKALRELEeqvegfVVIIDLKGFSLSNLSDLSLLKKLLKILQDH 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564341870 151 YKKNIKALYIVHPTMFIKTLLILFKPLISFKFGRKIFYVNY-LSELSEHVKLEQL 204
Cdd:cd00170   95 YPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSdLEELLEYIDPDQL 149
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-424 2.98e-22

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 93.74  E-value: 2.98e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREKNPNQepIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNM-GLPVDFDQ--YNELHLPAVIL 318
Cdd:cd04372    1 YGCDLTTLVKAHNTQ--RPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRdGEKADISAtvYPDINVITGAL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 319 KTFLRELPEPLLTFDLYPHIVGFLDLDD-DQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFG 397
Cdd:cd04372   79 KLYFRDLPIPVITYDTYPKFIDAAKISNpDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFG 158

                        170       180
                 ....*....|....*....|....*..
gi 564341870 398 PNLLWAKDAAiTLKAINPInTFTKFLL 424
Cdd:cd04372  159 PTLMRPPEDS-ALTTLNDM-RYQILIV 183
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 242-420 8.07e-22

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 92.37  E-value: 8.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLrekNPNQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGL-PVDFDQYNeLHLPAVILKT 320
Cdd:cd04406    1 FGVELSRL---TSEDRSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAnSVNLDDYN-IHVIASVFKQ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 321 FLRELPEPLLTFDLYPHIVGFLDLDDDQR-VEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPN 399
Cdd:cd04406   77 WLRDLPNPLMTFELYEEFLRAMGLQERREtVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPC 156

                        170       180
                 ....*....|....*....|.
gi 564341870 400 LLWAKDAAITLKAINPINTFT 420
Cdd:cd04406  157 ILRCPDTTDPLQSVQDISKTT 177
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 241-404 2.51e-21

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 91.03  E-value: 2.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 241 QFGVSLQHLREkNPNQEpIPIVLRETVAYLQAHALTaEGIFRRSANTQVVREVQQKYNMGLPVDFDQYN---ELHLPAVI 317
Cdd:cd04384    2 VFGCDLTEHLL-NSGQD-VPQVLKSCTEFIEKHGIV-DGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVyiqDIHSVSSL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 318 LKTFLRELPEPLLTFDLYPHIVGFLDLD-DDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVF 396
Cdd:cd04384   79 CKLYFRELPNPLLTYQLYEKFSEAVSAAsDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVW 158


                 ....*...
gi 564341870 397 GPNLLWAK 404
Cdd:cd04384  159 APNLLRSK 166
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-413 1.09e-19

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 87.17  E-value: 1.09e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREKNPNQepIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLP-VDFDQYNElHLPAVILKT 320
Cdd:cd04409    1 FGADFAQVAKKSPDG--IPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDlVELSELSP-HDISNVLKL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 321 FLRELPEPLLTFDLYPHIVGFLDldDDQRVEVTQQ-------------------------VLQTLPEENYRVLHFLTAFL 375
Cdd:cd04409   78 YLRQLPEPLILFRLYNEFIGLAK--ESQHVNETQEakknsdkkwpnmctelnrillkskdLLRQLPAPNYNTLQFLIVHL 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 564341870 376 VQVSAHSYQNRMNNTNLAVVFGPNLLWAK--DAAITLKAI 413
Cdd:cd04409  156 HRVSEQAEENKMSASNLGIIFGPTLIRPRptDATVSLSSL 195
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 242-407 1.16e-19

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 86.75  E-value: 1.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREKNPNQEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKY---NMGLPVDFDQYNELHLPAVIL 318
Cdd:cd04379    1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFernSAAVELSEELYPDINVITGVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 319 KTFLRELPEPLLTFDLYPHIVGFL--DLDDD--QRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAV 394
Cdd:cd04379   81 KDYLRELPEPLITPQLYEMVLEALavALPNDvqTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAV 160

                        170
                 ....*....|...
gi 564341870 395 VFGPNLLWAKDAA 407
Cdd:cd04379  161 CFGPVLMFCSQEF 173
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 242-400 3.23e-19

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 84.79  E-value: 3.23e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREKNPNQEPI--PIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFDQYnELHLPAVILK 319
Cdd:cd04381    1 FGASLSLAVERSRCHDGIdlPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEY-EPPTVASLLK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 320 TFLRELPEPLLTFDLYPHivgFLD----LDDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVV 395
Cdd:cd04381   80 QYLRELPEPLLTKELMPR---FEEacgrPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIV 156


                 ....*
gi 564341870 396 FGPNL 400
Cdd:cd04381  157 LSPTV 161
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 263-408 4.38e-19

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 85.14  E-value: 4.38e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 263 LRETVAYLQAHALTAEGIFRrsaNTQVVREVQQKYNMGL------PVDFDQYN---ELHLPAVILKTFLRELPEPLLTFD 333
Cdd:cd04374   32 VRKCIEAVETRGINEQGLYR---VVGVNSKVQKLLSLGLdpktstPGDVDLDNsewEIKTITSALKTYLRNLPEPLMTYE 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564341870 334 LYPHIVGFLDLDD-DQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPNLLWAKD---AAI 408
Cdd:cd04374  109 LHNDFINAAKSENlESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQEetvAAI 187
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 257-401 2.98e-18

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 82.47  E-value: 2.98e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 257 EPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGL-PVDFDQYN-ELHLPAVILKTFLRELPEPLLTFDL 334
Cdd:cd04383   16 QAIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEdPLADDQNDhDINSVAGVLKLYFRGLENPLFPKER 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564341870 335 YPHIVGFLDLDDDQ-RVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPNLL 401
Cdd:cd04383   96 FEDLMSCVKLENPTeRVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGPTLM 163
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 267-431 9.12e-18

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 81.35  E-value: 9.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 267 VAYLQAHaLTAEGIFRRSANTQVVREVQQKYNMGLPVDFDQYN-ELHLPAVILKTFLRELPEPLLTFDLYPHIVGFLDL- 344
Cdd:cd04392   17 IEYLEKN-LRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGfHAHDCATVLKGFLGELPEPLLTHAHYPAHLQIADLc 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 345 ------------DDDQRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPNLLW-----AKDAA 407
Cdd:cd04392   96 qfdekgnktsapDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICprnltPEDLH 175

                        170       180
                 ....*....|....*....|....
gi 564341870 408 ITLKAINPINTftkFLLDHQGELF 431
Cdd:cd04392  176 ENAQKLNSIVT---FMIKHSQKLF 196
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 242-401 2.54e-17

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 79.86  E-value: 2.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREKNPnqEPIPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLP-VDFDQyNELHLPAVILKT 320
Cdd:cd04408    1 FGVDFSQLPRDFP--EEVPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFENGRDlVDLSG-HSPHDITSVLKH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 321 FLRELPEPLLTFDLYPHIVGF---LDLDDDQRVEVT----------QQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRM 387
Cdd:cd04408   78 FLKELPEPVLPFQLYDDFIALakeLQRDSEKAAESPsiveniirslKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKM 157

                        170
                 ....*....|....
gi 564341870 388 NNTNLAVVFGPNLL 401
Cdd:cd04408  158 SPNNLGIVFGPTLL 171
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-431 8.92e-17

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 78.93  E-value: 8.92e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREKNPNQEP---IPIVLRETVAYLQAHALTAEGIFRRSANTQVV----REVQQKYNMGlPVDFDQYNElHLP 314
Cdd:cd04391    2 FGVPLSTLLERDQKKVPgskVPLIFQKLINKLEERGLETEGILRIPGSAQRVkflcQELEAKFYEG-TFLWDQVKQ-HDA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 315 AVILKTFLRELPEPLLTFDLYPhivGFLDLDDDQRVEVTQQVLQ----TLPEENYRVLHFLTAFLVQVSAHSYQNRMNNT 390
Cdd:cd04391   80 ASLLKLFIRELPQPLLTVEYLP---AFYSVQGLPSKKDQLQALNllvlLLPEANRDTLKALLEFLQKVVDHEEKNKMNLW 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 564341870 391 NLAVVFGPNL-----LWAKDAAITLKAINPINT---FTKFLLDHQGELF 431
Cdd:cd04391  157 NVAMIMAPNLfpprgKHSKDNESLQEEVNMAAGcanIMRLLIRYQDLLW 205
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 259-401 1.23e-15

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 74.96  E-value: 1.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 259 IPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAV--ILKTFLRELPEPLLTFDLYP 336
Cdd:cd04387   16 VPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNKDVSVMLSEMDVNAIagTLKLYFRELPEPLFTDELYP 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564341870 337 HIVGFLDLDDD-QRVEVTQQVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVVFGPNLL 401
Cdd:cd04387   96 NFAEGIALSDPvAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGPTLL 161
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 242-426 2.30e-15

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 73.96  E-value: 2.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHL----REKNPNQEpIPIV---LRETVAYLQAHalTAEGIFRRSANTQVVREVQQKYNMGLpVDFDQYNELHLP 314
Cdd:cd04389    1 FGSSLEEImdrqKEKYPELK-LPWIltfLSEKVLALGGF--QTEGIFRVPGDIDEVNELKLRVDQWD-YPLSGLEDPHVP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 315 AVILKTFLRELPEPLLTFDLYPHIVGFLDlDDDQRVEvtqqVLQTLPEENYRVLHFLTAFLVQVSAHSY--QNRMNNTNL 392
Cdd:cd04389   77 ASLLKLWLRELEEPLIPDALYQQCISASE-DPDKAVE----IVQKLPIINRLVLCYLINFLQVFAQPENvaHTKMDVSNL 151

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 564341870 393 AVVFGPNLL--WAKDAAITLKAINPINTFTKFLLDH 426
Cdd:cd04389  152 AMVFAPNILrcTSDDPRVIFENTRKEMSFLRTLIEH 187
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 248-400 1.62e-13

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 68.86  E-value: 1.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 248 HLREKNPNQEP-IPIVLRETVAYLQAHALTAEGIFRRSANTQVVREVQQKYNMGLPV----DFDqyneLHLPAVILKTFL 322
Cdd:cd04382    5 ELADFDPSTSPmIPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVpnlsKVD----IHVICGCLKDFL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564341870 323 RELPEPLLTFDLYPHIVGFLDLDDDQRVEVT-QQVLQTLPEENYRVLHFLTAFLvQVSAHSYQNRMNNTNLAVVFGPNL 400
Cdd:cd04382   81 RSLKEPLITFALWKEFMEAAEILDEDNSRAAlYQAISELPQPNRDTLAFLILHL-QRVAQSPECKMDINNLARVFGPTI 158
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 242-419 2.02e-12

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 66.21  E-value: 2.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 242 FGVSLQHLREKNPNQEP--IPIVLRETVAYLQAHALTAEGIFR----RSANTQVVREVQQKYNMGLPvdFDQYNELHLPA 315
Cdd:cd04380   31 LIDQLELGDNPDYSEVPlsIPKEIWRLVDYLYTRGLAQEGLFEepglPSEPGELLAEIRDALDTGSP--FNSPGSAESVA 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 316 VILKTFLRELPEPLLTFDLYPHIVGFLDLDDDQRVEVtqqVLQTLPEENYRVLHFLTAFLVQVSAHSYQNRMNNTNLAVV 395
Cdd:cd04380  109 EALLLFLESLPDPIIPYSLYERLLEAVANNEEDKRQV---IRISLPPVHRNVFVYLCSFLRELLSESADRGLDENTLATI 185

                        170       180       190
                 ....*....|....*....|....*....|.
gi 564341870 396 FGPNLL-------WAKDAAITLKAINPINTF 419
Cdd:cd04380  186 FGRVLLrdppragGKERRAERDRKRAFIEQF 216
CRAL_TRIO pfam00650
CRAL/TRIO domain;
77-204 4.61e-04

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 40.32  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870   77 GDDKYGRKIIVFSACRMPPsHQLDHSKLLGYLKHTLDQ--------YVESdYTLLYLHHGLTSDNKPS---------LSW 139
Cdd:pfam00650   8 GRDKEGRPVLYLRLGRHDP-KKSSEEELVRFLVLVLERalllmpegQVEG-LTVIIDLKGLSLSNMDWwsisllkkiIKI 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564341870  140 LRDAYREfdrkykkNIKALYIVHPTMFIKTLLILFKPLISFKFGRKIFYVN--YLSELSEHVKLEQL 204
Cdd:pfam00650  86 LQDNYPE-------RLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKnsNEEELEKYIPPEQL 145
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 303-401 8.35e-03

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 37.55  E-value: 8.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564341870 303 VDFDQYnELHLPAVILKTFLRELPEPLLTFDLYPHIVGFLDldDDQRVEVTQQVLQ------TLPEENYRVLHFLTAFLV 376
Cdd:cd04388   59 VDLEQF-DVAALADALKRYLLDLPNPVIPAPVYSEMISRAQ--EVQSSDEYAQLLRklirspNLPHQYWLTLQYLLKHFF 135

                         90       100
                 ....*....|....*....|....*
gi 564341870 377 QVSAHSYQNRMNNTNLAVVFGPNLL 401
Cdd:cd04388  136 RLCQSSSKNLLSARALAEIFSPLLF 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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