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Conserved domains on  [gi|564348849|ref|XP_006237376|]
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C3a anaphylatoxin chemotactic receptor isoform X1 [Rattus norvegicus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
24-434 2.18e-109

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15115:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 265  Bit Score: 324.41  E-value: 2.18e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15115    1 ILSLVVLSLTFLLGVPGNGLVIWVAGLKMKRTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFdssrayd 183
Cdd:cd15115   81 LNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGYDF------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 184 ywdymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliati 263
Cdd:cd15115      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 264 pggfpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhawtpQVAITISRLVVGFLVPFFIMITC 343
Cdd:cd15115  154 ---------------------------------------------------------LVAITITRAVFGFLLPLLIIAAC 176
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 344 YSLIVFRMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESAlrEVVLPWDHMSIALASANSCFNPFLY 423
Cdd:cd15115  177 YSFIAFRMQRGRFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGILSLYGDPPLS--KVLMSWDHLSIALAYANSCLNPVLY 254
                        410
                 ....*....|.
gi 564348849 424 ALLGKDFRKKA 434
Cdd:cd15115  255 VFMGKDFKKKA 265
 
Name Accession Description Interval E-value
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
24-434 2.18e-109

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 324.41  E-value: 2.18e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15115    1 ILSLVVLSLTFLLGVPGNGLVIWVAGLKMKRTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFdssrayd 183
Cdd:cd15115   81 LNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGYDF------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 184 ywdymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliati 263
Cdd:cd15115      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 264 pggfpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhawtpQVAITISRLVVGFLVPFFIMITC 343
Cdd:cd15115  154 ---------------------------------------------------------LVAITITRAVFGFLLPLLIIAAC 176
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 344 YSLIVFRMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESAlrEVVLPWDHMSIALASANSCFNPFLY 423
Cdd:cd15115  177 YSFIAFRMQRGRFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGILSLYGDPPLS--KVLMSWDHLSIALAYANSCLNPVLY 254
                        410
                 ....*....|.
gi 564348849 424 ALLGKDFRKKA 434
Cdd:cd15115  255 VFMGKDFKKKA 265
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
40-423 1.03e-34

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 130.11  E-value: 1.03e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849   40 GNGLVLWV-AGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLLTAIS 117
Cdd:pfam00001   1 GNLLVILViLRNKKLRTPTNIFLLNLAVADLLfSLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  118 LDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRdllvvddysvcgynfdssraydywdymynshlpein 197
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFG------------------------------------ 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  198 ppdnstghvddrtapssvpardlWTATTALQSQTFHTspedpfsqdsasqqphyggkpptvliatipggfpvedhksntl 277
Cdd:pfam00001 125 -----------------------WTLTVPEGNVTVCF------------------------------------------- 138
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  278 ntgaflsahtepsltasssplyahdfpddyfdqLMYGNHAWTPqVAITISRLVVGFLVPFFIMITCYSLIVFRMRKTNLT 357
Cdd:pfam00001 139 ---------------------------------IDFPEDLSKP-VSYTLLISVLGFLLPLLVILVCYTLIIRTLRKSASK 184
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564348849  358 KSRN-------KTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLpWDHMSIALASANSCFNPFLY 423
Cdd:pfam00001 185 QKSSertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLDK-ALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
17-439 1.76e-16

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 80.21  E-value: 1.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  17 PLFKPQDIASMVILSLTCL---LGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRgHWPYGLF 93
Cdd:PHA03087  31 DLNIGYDTNSTILIVVYSTiffFGLVGNIIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILF-QWSFGEF 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  94 LCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCg 173
Cdd:PHA03087 110 ACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLIC- 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 174 ynfdssraydywdYMYnshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphygg 253
Cdd:PHA03087 189 -------------CMF---------------------------------------------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 254 kpptvliatipggfpvedhksntlntgaflsahtepsltasssplyahdfpddYFDQLMYgnhaWTPQVAITISrlVVGF 333
Cdd:PHA03087 192 -----------------------------------------------------YNNKTMN----WKLFINFEIN--IIGM 212
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 334 LVPFFIMITCYSLIVFRMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGI-----LLVITDQESALREVVLPWdHMS 408
Cdd:PHA03087 213 LIPLTILLYCYSKILITLKGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFvyslhILHFKSGCKAVKYIQYAL-HVT 291
                        410       420       430
                 ....*....|....*....|....*....|.
gi 564348849 409 IALASANSCFNPFLYALLGKDFRKKARQSVK 439
Cdd:PHA03087 292 EIISLSHCCINPLIYAFVSEFFNKHKKKSLK 322
 
Name Accession Description Interval E-value
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
24-434 2.18e-109

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 324.41  E-value: 2.18e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15115    1 ILSLVVLSLTFLLGVPGNGLVIWVAGLKMKRTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFdssrayd 183
Cdd:cd15115   81 LNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGYDF------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 184 ywdymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliati 263
Cdd:cd15115      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 264 pggfpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhawtpQVAITISRLVVGFLVPFFIMITC 343
Cdd:cd15115  154 ---------------------------------------------------------LVAITITRAVFGFLLPLLIIAAC 176
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 344 YSLIVFRMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESAlrEVVLPWDHMSIALASANSCFNPFLY 423
Cdd:cd15115  177 YSFIAFRMQRGRFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGILSLYGDPPLS--KVLMSWDHLSIALAYANSCLNPVLY 254
                        410
                 ....*....|.
gi 564348849 424 ALLGKDFRKKA 434
Cdd:cd15115  255 VFMGKDFKKKA 265
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
24-433 2.20e-94

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 286.50  E-value: 2.20e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd14974    1 IVSLVLYALIFLLGLPGNGLVIWVAGFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSFVIS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCgynfdssrayd 183
Cdd:cd14974   81 LNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSC----------- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 184 ywdymynshlpeinppdNSTGHVDDRTAPSsvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliati 263
Cdd:cd14974  150 -----------------NLTCVEDYDLRRS-------------------------------------------------- 162
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 264 pggfpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhawtPQVAITISRLVVGFLVPFFIMITC 343
Cdd:cd14974  163 --------------------------------------------------------RHKALTVIRFLCGFLLPLLIIAIC 186
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 344 YSLIVFRMRKTNLTKSRnKTLRVAVAVVTVFFVCWIPYHIVGILLviTDQESALREVVLPWDHMSIALASANSCFNPFLY 423
Cdd:cd14974  187 YSVIAVKLRRKRLAKSS-KPLRVLLAVVVAFFLCWLPYHVFALLE--LVAAAGLPEVVLLGLPLATGLAYFNSCLNPILY 263
                        410
                 ....*....|
gi 564348849 424 ALLGKDFRKK 433
Cdd:cd14974  264 VFMGQDFRKR 273
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
24-432 2.94e-74

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 234.61  E-value: 2.94e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15114    1 VVALVLYAVVFLVGVPGNALVAWVTGFEAKRSVNAVWFLNLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSLIL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLlvvddysvcgynfdssrayd 183
Cdd:cd15114   81 LNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRI-------------------- 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 184 ywdymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqQPHYggkpptvliati 263
Cdd:cd15114  141 ----------------------------------------------------------------HQEH------------ 144
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 264 pggfpvedhksntlntgaflsahtepsltasssplyahdFPDDYFDQLMYGnHAWTPQVAITISRLVVGFLVPFFIMITC 343
Cdd:cd15114  145 ---------------------------------------FPEKTVCVVDYG-GSTGVEWAVAIIRFLLGFLGPLVVIASC 184
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 344 YSLIVFRMRKTNLTKSRnKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLPWDHMSIALASANSCFNPFLY 423
Cdd:cd15114  185 HGVLLVRTWSRRRQKSR-RTLKVVTAVVVGFFLCWTPYHVVGLIIAASAPNSRLLANALKADPLTVSLAYINSCLNPIIY 263

                 ....*....
gi 564348849 424 ALLGKDFRK 432
Cdd:cd15114  264 VVAGRGFRK 272
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
24-433 1.00e-67

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 218.45  E-value: 1.00e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15117    1 ILSLVIYSSAFVLGTLGNGLVIWVTGFRMTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFDssrayd 183
Cdd:cd15117   81 FNLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRKENGCTHCYLNFD------ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 184 ywdymynshlpeinpPDNSTGHVddrtapssvpaRDLWTATTalqsqtfhtspedpfsqdsasqqphyggkpptvliati 263
Cdd:cd15117  155 ---------------PWNETAED-----------PVLWLETV-------------------------------------- 170
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 264 pggfpVEDHKsntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhawtpqvAITISRLVVGFLVPFFIMITC 343
Cdd:cd15117  171 -----VQRLS-------------------------------------------------AQVITRFVLGFLVPLVIIGGC 196
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 344 YSLIVFRMRKTNLTKSRnKTLRVAVAVVTVFFVCWIPYHIVGI--LLVITDQESALREVVLPWDHMSIALASANSCFNPF 421
Cdd:cd15117  197 YGLIAARLWREGWVHSS-RPFRVLTAVVAAFFLCWFPFHLVSLleLVVILNQKEDLNPLLILLLPLSSSLACVNSCLNPL 275
                        410
                 ....*....|..
gi 564348849 422 LYALLGKDFRKK 433
Cdd:cd15117  276 LYVFVGRDFRER 287
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
24-433 3.05e-66

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 214.24  E-value: 3.05e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15116    1 ILSMVIYSVVFVLGVLGNGLVIFITGFKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNSFLLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDL--LVVDDYSVCGYNFDSSRA 181
Cdd:cd15116   81 LNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTapSQNNNKIICFNNFSLSGD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 182 YDYwdymynshlPEINPPDNSTghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvlia 261
Cdd:cd15116  161 NSS---------PEVNQLRNMR---------------------------------------------------------- 173
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 262 tipggfpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhawtpQVAITISRLVVGFLVPFFIMI 341
Cdd:cd15116  174 -----------------------------------------------------------HQVMTITRFLLGFLIPFTIII 194
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 342 TCYSLIVFRMRKTNLTKSRnKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALR-EVVLPwdhMSIALASANSCFNP 420
Cdd:cd15116  195 CCYAAIVLKLKRNRLAKSS-KPFKIIAAVIVTFFLCWAPYHILNLLEMEATRSPASVfKIGLP---ITSSLAFINSCLNP 270
                        410
                 ....*....|...
gi 564348849 421 FLYALLGKDFRKK 433
Cdd:cd15116  271 ILYVFMGQDFKKF 283
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
24-431 1.22e-51

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 176.09  E-value: 1.22e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15119    1 IVSIVIYIVAFVLGVPGNAIVIWVTGFKWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVV-DDYSVCGYNFdssray 182
Cdd:cd15119   81 LNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMELsINVTICFNNF------ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 183 dywdymynshlpeinppdnstgHVDDRtapssvpardlwtaTTALQSQTFhtspedpfsqdsasqqphyggkpptvliat 262
Cdd:cd15119  155 ----------------------HKHDG--------------DLIVMRHTI------------------------------ 168
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 263 ipggfpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhawtpqvaITISRLVVGFLVPFFIMIT 342
Cdd:cd15119  169 -------------------------------------------------------------LVWVRFFFGFLFPLLTMVV 187
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 343 CYSLIVFRMRKTNLTKSrNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLPWDHMSIALASANSCFNPFL 422
Cdd:cd15119  188 CYSLLAIKVKRRTLLIS-SKFFWTISAVIVAFFVCWTPYHIFSILELSIHHSSYLHNVLRAGIPLATSLAFINSCLNPIL 266

                 ....*....
gi 564348849 423 YALLGKDFR 431
Cdd:cd15119  267 YVLIGKKFK 275
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
24-432 1.28e-50

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 173.43  E-value: 1.28e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15120    1 VLIAVALFVTFLVGLVVNGLYLWVLGFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNSTLS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNfdssrayd 183
Cdd:cd15120   81 VGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRLDEKGKTICQN-------- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 184 ywDYMYNShlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfSQDSASQQphyggkpptvliati 263
Cdd:cd15120  153 --NYALST-------------------------------------------------NWESAEVQ--------------- 166
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 264 pggfpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmyGNHAWTpQVAITISRLVVGFLVPFFIMITC 343
Cdd:cd15120  167 --------------------------------------------------ASRQWI-HVAMFVFRFLLGFLLPFLIITFC 195
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 344 YSLIVFRMRKTNLTKSRnKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLPwdhMSIALASANSCFNPFLY 423
Cdd:cd15120  196 YVRMALKMKERGLARSS-KPFKVMFTAVVSFFVCWLPYHLHSGLVLTRGRPPSLTDITLL---LTVGTTCFNTCFTPVLY 271

                 ....*....
gi 564348849 424 ALLGKDFRK 432
Cdd:cd15120  272 LFVGENFKK 280
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
24-176 4.43e-42

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 151.11  E-value: 4.43e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15118    1 VATICLHGIVSTLGIVENLLILWVVGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFF 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLL-VVDDYSVCGYNF 176
Cdd:cd15118   81 LNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIeRKDGRKLCYYNF 154
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
24-432 2.79e-39

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 143.20  E-value: 2.79e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVA--GVKMKrTVNTVWFLHLTLADFLCCLSLPFSVAHLILrGHWPYGLFLCKLIPSV 101
Cdd:cd14970    1 IVIPAVYSVVCVVGLTGNSLVIYVIlrYSKMK-TVTNIYILNLAVADELFLLGLPFLATSYLL-GYWPFGEVMCKIVLSV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYrdllvvddysvcgynfdssra 181
Cdd:cd14970   79 DAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIF--------------------- 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 182 ydywdymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsASQQPHYGGKPPTVLia 261
Cdd:cd14970  138 ---------------------------------------------------------------ARTLQEEGGTISCNL-- 152
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 262 tipggfpvedhksntlntgaflsahtepsltasssplyahDFPDDYfdqlMYGNHAWtpqvaiTISRLVVGFLVPFFIMI 341
Cdd:cd14970  153 ----------------------------------------QWPDPP----DYWGRVF------TIYTFVLGFAVPLLVIT 182
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 342 TCYSLIVFRMRKTNL---------TKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLPwdHMSIALA 412
Cdd:cd14970  183 VCYSLIIRRLRSSRNlstsgarekRRARRKVTRLVLVVVAVFVVCWLPFHVFQIVRLLIDPPETLTVVGVF--LFCIALS 260
                        410       420
                 ....*....|....*....|
gi 564348849 413 SANSCFNPFLYALLGKDFRK 432
Cdd:cd14970  261 YANSCLNPILYAFLDENFRK 280
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
24-433 2.98e-39

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 143.17  E-value: 2.98e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVI 102
Cdd:cd14982    1 TLFPIVYSLIFILGLLGNILALWVFLRKMKkRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 103 ILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRdllvvddysvcgynfdssray 182
Cdd:cd14982   81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLR--------------------- 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 183 dywdymynshlpeinppdnSTGHVDDRTapssvpardlwtattalqSQTFHTSPEdpfsqdsasqqphyggkpptvliat 262
Cdd:cd14982  140 -------------------STIAKENNS------------------TTCFEFLSE------------------------- 157
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 263 ipggfpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhAWTPQVAITISRLVVGFLVPFFIMIT 342
Cdd:cd14982  158 ------------------------------------------------------WLASAAPIVLIALVVGFLIPLLIILV 183
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 343 CYSLIV--FRMRKTNLTKSRNKT--LRVAVAVVTVFFVCWIPYHIVGILLVI----TDQESALREVVLPWDHMSIALASA 414
Cdd:cd14982  184 CYSLIIraLRRRSKQSQKSVRKRkaLRMILIVLAVFLVCFLPYHVTRILYLLvrlsFIADCSARNSLYKAYRITLCLASL 263
                        410
                 ....*....|....*....
gi 564348849 415 NSCFNPFLYALLGKDFRKK 433
Cdd:cd14982  264 NSCLDPLIYYFLSKTFRKR 282
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
40-423 1.03e-34

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 130.11  E-value: 1.03e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849   40 GNGLVLWV-AGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLLTAIS 117
Cdd:pfam00001   1 GNLLVILViLRNKKLRTPTNIFLLNLAVADLLfSLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  118 LDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRdllvvddysvcgynfdssraydywdymynshlpein 197
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFG------------------------------------ 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  198 ppdnstghvddrtapssvpardlWTATTALQSQTFHTspedpfsqdsasqqphyggkpptvliatipggfpvedhksntl 277
Cdd:pfam00001 125 -----------------------WTLTVPEGNVTVCF------------------------------------------- 138
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  278 ntgaflsahtepsltasssplyahdfpddyfdqLMYGNHAWTPqVAITISRLVVGFLVPFFIMITCYSLIVFRMRKTNLT 357
Cdd:pfam00001 139 ---------------------------------IDFPEDLSKP-VSYTLLISVLGFLLPLLVILVCYTLIIRTLRKSASK 184
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564348849  358 KSRN-------KTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLpWDHMSIALASANSCFNPFLY 423
Cdd:pfam00001 185 QKSSertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLDK-ALSVTLWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
27-426 4.21e-34

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 128.95  E-value: 4.21e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLILrGHWPYGLFLCKLIPSVIIL 104
Cdd:cd00637    2 AVLYILIFVVGLVGNLLVILViLRNRRLRTVTNYFILNLAVADLLvGLLVIPFSLVSLLL-GRWWFGDALCKLLGFLQSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFDSsraydy 184
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPD------ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 185 wdymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliatip 264
Cdd:cd00637      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 265 ggfpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhaWTPQVAITISRLVVGFLVPFFIMITCY 344
Cdd:cd00637  155 -----------------------------------------------------LTLSKAYTIFLFVLLFLLPLLVIIVCY 181
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 345 SLIVFRMRKTNLTKSRNKTLRVAVAVVTVFF--------------VCWIPYHIVGILLVITDQESALREVVLpwdHMSIA 410
Cdd:cd00637  182 VRIFRKLRRHRRRIRSSSSNSSRRRRRRRERkvtktllivvvvflLCWLPYFILLLLDVFGPDPSPLPRILY---FLALL 258
                        410
                 ....*....|....*.
gi 564348849 411 LASANSCFNPFLYALL 426
Cdd:cd00637  259 LAYLNSAINPIIYAFF 274
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
28-434 4.73e-34

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 129.42  E-value: 4.73e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd14985    5 ALYIAIFLVGLLGNLFVVWVFLFPRGpKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVISVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVV--DDYSVCGYNFDSsraydy 184
Cdd:cd14985   85 FASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIenLNKTACIMLYPH------ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 185 wdymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliatip 264
Cdd:cd14985      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 265 ggfpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhaWTPQVAITISRLVVGFLVPFFIMITCY 344
Cdd:cd14985  159 -----------------------------------------------------EAWHFGLSLELNILGFVLPLLIILTCY 185
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 345 SLIVFRMRKTNLT-----KSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITdQESALR----EVVLPWD-HMSIALASA 414
Cdd:cd14985  186 FHIARSLRKRYERtgkngRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLA-QLGAIRpcfwELFLDLGlPIATCLAFT 264
                        410       420
                 ....*....|....*....|
gi 564348849 415 NSCFNPFLYALLGKDFRKKA 434
Cdd:cd14985  265 NSCLNPFIYVFVDRRFRQKV 284
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
28-429 2.37e-31

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 121.82  E-value: 2.37e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVaHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd14975    5 TLLSLAFAIGLPGNSFVIWSILIKVKqRSVTMLLVLNLALADLAVLLTLPVWI-YFLATGTWDFGLAACKGCVYVCAVSM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNfdssraydywd 186
Cdd:cd14975   84 YASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMCKYR----------- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 187 ymynshlpeinppDNSTGHvddrtapssvpardlwtattalqsQTFHtspedpfsqdsasqqphyggkpptvliatipgg 266
Cdd:cd14975  153 -------------HYSDGQ------------------------LVFH--------------------------------- 162
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 267 fpvedhksNTLNTgaflsahtepsltasssplyahdfpddyfdqlmygnhawtpqvaitisrlVVGFLVPFFIMITCYSL 346
Cdd:cd14975  163 --------LLLET--------------------------------------------------VVGFAVPFTAVVLCYSC 184
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 347 IVFRMRKTNLtKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQES------ALREVVLPWDHMSIALASANSCFNP 420
Cdd:cd14975  185 LLRRLRRRRF-RRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVSELIGgskmagTLGKVAEAGRPIAGALAFLSSSINP 263

                 ....*....
gi 564348849 421 FLYALLGKD 429
Cdd:cd14975  264 LLYAFAARG 272
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
28-431 9.88e-31

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 120.11  E-value: 9.88e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15168    5 IVYGVVFLVGLLLNSVVLYRFIFHLKPwNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRFLFYFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCgynfdssraydyWD 186
Cdd:cd15168   85 YGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTC------------YD 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 187 ymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliatipgg 266
Cdd:cd15168      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 267 fpvedhksntlntgaflsahtepsltassspLYAHDFPDDYfdqLMYGnhawtpqVAITISrlvvGFLVPFFIMITCYSL 346
Cdd:cd15168  153 -------------------------------TTSPEELNDY---VIYS-------MVLTGL----GFLLPLLIILACYGL 187
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 347 IVFRMRKTN----LTKSRNKTLRVAVAVVTVFFVCWIPYHI---VGILLVITDQES--ALREVVLPWDHMSIALASANSC 417
Cdd:cd15168  188 IVRALIRKLgegvTSALRRKSIRLVIIVLALFAVCFLPFHVtrtINLAARLLSGTAscATLNGIYVAYKVTRPLASLNSC 267
                        410
                 ....*....|....
gi 564348849 418 FNPFLYALLGKDFR 431
Cdd:cd15168  268 LNPLLYFLAGDKFR 281
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
28-432 7.13e-29

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 115.00  E-value: 7.13e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLIlrGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd14984    5 VLYSLVFLLGLVGNSLVLLVLLYYRKlRSMTDVYLLNLALADLLFVLTLPFWAVYAA--DGWVFGSFLCKLVSALYTINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFDSSRAYDYWd 186
Cdd:cd14984   83 YSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEDTATTWK- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 187 ymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliatipgg 266
Cdd:cd14984      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 267 fpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhawtpqVAITISRLVVGFLVPFFIMITCYSL 346
Cdd:cd14984  162 -------------------------------------------------------TLLRLLQNILGFLLPLLVMLFCYSR 186
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 347 IV---FRMRKtnltKSRNKTLRVAVAVVTVFFVCWIPYHIVGIL-----LVITDQESALREVVLPWDHMSIALASANSCF 418
Cdd:cd14984  187 IIrtlLRARN----HKKHRALRVIFAVVVVFFLCWLPYNIVLLLdtlqlLGIISRSCELSKSLDYALQVTESLAFSHCCL 262
                        410
                 ....*....|....
gi 564348849 419 NPFLYALLGKDFRK 432
Cdd:cd14984  263 NPVLYAFVGVKFRK 276
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
27-164 3.02e-28

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 112.99  E-value: 3.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVLWVAGVKM-KRTVNTVWFLHLTLADFLCCLSLPFSVaHLILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15121    4 IAILSLAFILGFPGNLFVVWSVLCRMkKRSVTCILVLNLALADAAVLLTAPFFL-HFLSGGGWEFGSVVCKLCHYVCGVS 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLL 164
Cdd:cd15121   83 MYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVL 141
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
29-432 3.42e-28

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 112.94  E-value: 3.42e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVA--GVKMKrTVNTVWFLHLTLADFLCCLSLPFSVAHLILRgHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15093    6 IYAVVCLVGLCGNSLVIYVVlrYAKMK-TVTNIYILNLAIADELFMLGLPFLAASNALR-HWPFGSVLCRLVLSVDGINM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVV-DDYSVCgynfdssraydyw 185
Cdd:cd15093   84 FTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENqDGSSAC------------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 186 dymyNSHLPEinppdnstghvddrtaPSSvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliatipg 265
Cdd:cd15093  151 ----NMQWPE----------------PAA--------------------------------------------------- 159
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 266 gfpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhAWTpqVAITISRLVVGFLVPFFIMITCYS 345
Cdd:cd15093  160 ---------------------------------------------------AWS--AGFIIYTFVLGFLLPLLIICLCYL 186
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 346 LIVFRMRKTNL-------TKSRNKTLRVAVAVVTVFFVCWIPYHIVGI--LLVITDQESALREVvlpwDHMSIALASANS 416
Cdd:cd15093  187 LIVIKVKSAGLragwqqrKRSERKVTRMVVMVVVVFVICWLPFYVLQLvnVFVQLPETPALVGV----YHFVVILSYANS 262
                        410
                 ....*....|....*.
gi 564348849 417 CFNPFLYALLGKDFRK 432
Cdd:cd15093  263 CANPILYGFLSDNFKK 278
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
28-433 7.10e-28

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 112.14  E-value: 7.10e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15192    5 TVYSIIFVVGIFGNSLVVIVIYCYMKlKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDY--SVCGYNFDSSRaydy 184
Cdd:cd15192   85 YASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIENTniTVCAFHYPSQN---- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 185 wdymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliatip 264
Cdd:cd15192      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 265 ggfpvedhksntlntgaflsahtepsltasssplyahdfpddyfDQLMYGnhawtpqvaITISRLVVGFLVPFFIMITCY 344
Cdd:cd15192  161 --------------------------------------------STLLVG---------LGLMKNLLGFLIPFLIILTCY 187
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 345 SLI---VFRMRKTNLTKSRN-KTLRVAVAVVTVFFVCWIPYHIVGILLVITD----QESALREVVLPWDHMSIALASANS 416
Cdd:cd15192  188 TLIgkaLKKAYEIQRNKPRNdEIFKMIMAVVLFFFFCWIPHQIFTFLDVLIQlkviQDCHIADIVDTAMPFTICIAYFNS 267
                        410
                 ....*....|....*..
gi 564348849 417 CFNPFLYALLGKDFRKK 433
Cdd:cd15192  268 CLNPILYGFVGKNFRKK 284
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
24-184 2.67e-27

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 110.44  E-value: 2.67e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAG-VKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLIlrGHWPYGLFLCKLIPSVI 102
Cdd:cd15178    1 LALCVIYVLVFLLSLPGNSLVVLVILyNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVV--KGWIFGTFMCKLVSLLQ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 103 ILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFaVCGCVWVVAFVMCIPVFVYRDLLVVDDYS--VCGYNFDSSR 180
Cdd:cd15178   79 EANFYSGILLLACISVDRYLAIVHATRALTQKRHLVKF-VCAGVWLLSLLLSLPALLNRDAFKPPNSGrtVCYENLGNES 157

                 ....
gi 564348849 181 AYDY 184
Cdd:cd15178  158 ADKW 161
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
32-172 6.32e-27

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 109.27  E-value: 6.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  32 LTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADF--LCCLSLpFSVAHLiLRGHWPYGlFLCKLIPSVIILNMFAS 109
Cdd:cd14973    9 LLSLCGLVGNGLVLWLLGFRIKRNPFSVYILNLAAADFlfLSCQAI-QSLEDL-LGGSLPGF-ALCRLLATLMFFSYTVG 85
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564348849 110 VFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVV-DDYSVC 172
Cdd:cd14973   86 LSLLAAISTERCLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSVLESYFCGFLFWkFNESAC 149
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
28-433 6.24e-26

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 106.77  E-value: 6.24e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15088    5 SVFGCICVVGLVGNGIVLYVLVRCSKlRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALDANNQ 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLlvvddysvcgynfdssraydywd 186
Cdd:cd15088   85 FTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSL----------------------- 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 187 ymynshlpeINPPDNSTGHVDDRTAPSSVpardLWtattalqsqtfhtspedpfsqdsasqqphyggkpptvliatipgg 266
Cdd:cd15088  142 ---------IYFPDGTTFCYVSLPSPDDL----YW--------------------------------------------- 163
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 267 fpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhawtpqvaITISRLVVGFLVPFFIMITCYSL 346
Cdd:cd15088  164 ---------------------------------------------------------FTIYHFILGFAVPLVVITVCYIL 186
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 347 IVFRM-------RKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLpwdHMSIALASANSCFN 419
Cdd:cd15088  187 ILHRLargvapgNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLVNLAMNRPTLAFEVAY---FLSICLGYANSCLN 263
                        410
                 ....*....|....
gi 564348849 420 PFLYALLGKDFRKK 433
Cdd:cd15088  264 PFVYILVSENFRKR 277
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
24-163 6.89e-26

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 106.43  E-value: 6.89e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMK---RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGhWPYGLFLCKLIPS 100
Cdd:cd15122    1 ATGTIFLLLAALLGLPGNGFIIWSILWKMKargRSVTCILILNLAVADGAVLLLTPFFITFLTRKT-WPFGQAVCKAVYY 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564348849 101 VIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDL 163
Cdd:cd15122   80 LCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHV 142
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-433 8.11e-26

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 106.77  E-value: 8.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVA--GVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15190   15 VIYMLVFVLGLSGNGLVLWTVfrSKRKRRRSADTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYLVFVN 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFDSSraydyw 185
Cdd:cd15190   95 MYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVICDMDYS------ 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 186 dymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliatipg 265
Cdd:cd15190      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 266 gfpvedhksntlntgaflsahtepSLTASSSplyahdfpddyfdqlmygNHAWTpqVAITISRLVVGFLVPFFIMITCYS 345
Cdd:cd15190  169 ------------------------GVVSNES------------------EWAWI--AGLGLSSTVLGFLLPFLIMLTCYF 204
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 346 LI--VFRMRKTNLT----KSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQEsalrevVLPW----DHM-------S 408
Cdd:cd15190  205 FIgrTVARHFSKLRrkedKKKRRLLKIIITLVVTFALCWLPFHLVKTLYALMYLG------ILPFscgfDLFlmnahpyA 278
                        410       420
                 ....*....|....*....|....*
gi 564348849 409 IALASANSCFNPFLYALLGKDFRKK 433
Cdd:cd15190  279 TCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
28-161 1.02e-25

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 105.99  E-value: 1.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMF 107
Cdd:cd15372    5 SLYTLVFLVGLPANGLALWVLATQVKRLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNMY 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564348849 108 ASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYR 161
Cdd:cd15372   85 CSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQR 138
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
28-181 8.26e-25

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 103.84  E-value: 8.26e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLW-VAGVKMKRTVNTVWFLHLTLAD-FLCCLSLPFSVaHLILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15203    5 LLYGLIIVLGVVGNLLVIYvVLRNKSMQTVTNIFILNLAVSDlLLCLVSLPFTL-IYTLTKNWPFGSILCKLVPSLQGVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIwcQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVD------DYSVCGYNFDSS 179
Cdd:cd15203   84 IFVSTLTLTAIAIDRYQLIVYPT--RPRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPieilpyCGYFCTESWPSS 161

                 ..
gi 564348849 180 RA 181
Cdd:cd15203  162 SS 163
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
24-160 2.52e-24

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 102.17  E-value: 2.52e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVA--GVKMKrTVNTVWFLHLTLADFLCCLSLPFSVAHLILrGHWPYGLFLCKLIPSV 101
Cdd:cd15094    1 LISAVLYGLICIVGLVGNGLVIYVVlrYAKMK-TVTNLYILNLAVADECFLIGLPFLIVTMIL-KYWPFGAAMCKIYMVL 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY 160
Cdd:cd15094   79 TSINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILY 137
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
28-187 6.96e-24

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 101.04  E-value: 6.96e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV----AGVKMKRTVNTVWFlHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd14976    5 VVYMVVFTVGLLGNLLVLYLlksnKKLRQQSESNKFVF-NLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTK 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY-RDLLVVDDYSVCGYNFDSSRAY 182
Cdd:cd14976   84 LNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFsTDTWSSVNHTLCLLRFPKNSSV 163

                 ....*
gi 564348849 183 DYWDY 187
Cdd:cd14976  164 TRWYN 168
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
29-432 8.47e-24

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 100.76  E-value: 8.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVA--GVKMKRTVNtVWFLHLTLADFLCCLSLPFSVAHLILRgHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15970    6 IYSVVCLVGLCGNSMVIYVIlrYAKMKTATN-IYILNLAIADELLMLSVPFLVTSTLLR-HWPFGSLLCRLVLSVDAINM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYrdllvvddysvcgynfdssraydywd 186
Cdd:cd15970   84 FTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIF-------------------------- 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 187 ymynshlpeinppdnstghvdDRTAPSSvpardlwTATTALQSQTfhtspedpfsqdsasqqphyggkpptvliatipgg 266
Cdd:cd15970  138 ---------------------SNTAPNS-------DGSVACNMQM----------------------------------- 154
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 267 fpvedhksntlntgaflsahTEPSltasssplyahdfpddyfdqlmygnHAWTpqVAITISRLVVGFLVPFFIMITCYSL 346
Cdd:cd15970  155 --------------------PEPS-------------------------QRWL--AVFVVYTFLMGFLLPVIAICLCYIL 187
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 347 IVFRMRKTNLT-------KSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESAlrevvlPWDHMSIALASANSCFN 419
Cdd:cd15970  188 IIVKMRVVALKagwqqrkRSERKITLMVMMVVTVFVICWMPFYVVQLVSVFVGQHDA------TVSQLSVILGYANSCAN 261
                        410
                 ....*....|...
gi 564348849 420 PFLYALLGKDFRK 432
Cdd:cd15970  262 PILYGFLSDNFKR 274
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
29-432 1.09e-23

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 100.32  E-value: 1.09e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVA--GVKMKRTVNtVWFLHLTLADFLCCLSLPFSVAHLILRgHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15973    6 IYALVCLVGLIGNSMVIFVIlrYAKMKTATN-IYILNLAIADELFMLSVPFLAASAALQ-HWPFGSAMCRTVLSVDGINM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGynfdssraydywd 186
Cdd:cd15973   84 FTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVAC------------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 187 ymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliatipgg 266
Cdd:cd15973      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 267 fpvedhksntlntgaflsahtepsltasssplyahdfpddyfdQLMYGNHAWTpqVAITISRLVVGFLVPFFIMITCYSL 346
Cdd:cd15973  151 -------------------------------------------NLIWPHPAWS--AAFVIYTFLLGFLLPVLAIGLCYIL 185
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 347 IVFRMRKTNLT-------KSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESAlrevvlPWDHMSIALASANSCFN 419
Cdd:cd15973  186 IIGKMRAVALKagwqqrrKSEKKITRMVLMVVTVFVICWMPFYVVQLLNLFLPRLDA------TVNHASLILSYANSCAN 259
                        410
                 ....*....|...
gi 564348849 420 PFLYALLGKDFRK 432
Cdd:cd15973  260 PILYGFLSDNFRR 272
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
35-179 4.40e-23

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 98.67  E-value: 4.40e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWVAGVK--MKRTVNTvWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFL 112
Cdd:cd15193   12 FTGLLGNLFVIALMSKRstTKRLVDT-FVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAVNRCSSILF 90
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 113 LTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLvvdDYSVCGYNFDSS 179
Cdd:cd15193   91 LTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLI---NESVCVEDSSSR 154
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
24-432 4.48e-23

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 98.83  E-value: 4.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLILRGhWPYGLFLCKLIPSV 101
Cdd:cd14993    1 IVLIVLYVVVFLLALVGNSLVIAVvLRNKHMRTVTNYFLVNLAVADLLvSLFCMPLTLLENVYRP-WVFGEVLCKAVPYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDysvcgynfdssra 181
Cdd:cd14993   80 QGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIIS------------- 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 182 ydywdymynshlpeiNPPDNSTGHVddrtapssvpARDLWTATTalqsqtfhtspedpfsqdsasqqphyggkpptvlia 261
Cdd:cd14993  147 ---------------SEPGTITIYI----------CTEDWPSPE------------------------------------ 165
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 262 tipggfpvedhksntlntgaflsahtepsltasssplyahdfpddyfDQLMYgnhawtpQVAItisrLVVGFLVPFFIMI 341
Cdd:cd14993  166 -----------------------------------------------LRKAY-------NVAL----FVVLYVLPLLIIS 187
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 342 TCYSLIVFRMR---------------KTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLPWDH 406
Cdd:cd14993  188 VAYSLIGRRLWrrkppgdrgsanstsSRRILRSKKKVARMLIVVVVLFALSWLPYYVLSILLDFGPLSSEESDENFLLIL 267
                        410       420
                 ....*....|....*....|....*..
gi 564348849 407 MSIA-LASANSCFNPFLYALLGKDFRK 432
Cdd:cd14993  268 PFAQlLGYSNSAINPIIYCFMSKKFRR 294
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
31-157 1.11e-22

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 97.42  E-value: 1.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  31 SLTCLLGLPGNGLVLWVAGVKMKRTVNT-VWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFAS 109
Cdd:cd15159    8 SLILVFGLLGNTLALHVICQKRKKINSTtLYLINLAVSDILFTLALPGRIAYYALGFDWPFGDWLCRLTALLFYINTYAG 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564348849 110 VFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPV 157
Cdd:cd15159   88 VNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPL 135
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
28-432 2.05e-22

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 96.09  E-value: 2.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLC-CLSLPFSVAHLILrGHWPYGLFLCKLIPSVIILN 105
Cdd:cd14967    4 VFLSLIILVTVFGNLLViLAVYRNRRLRTVTNYFIVSLAVADLLVaLLVMPFSAVYTLL-GYWPFGPVLCRFWIALDVLC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFDSSRAYdyw 185
Cdd:cd14967   83 CTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKIY--- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 186 dymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliatipg 265
Cdd:cd14967      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 266 gfpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhawtpqvaiTISRLVVGFLVPFFIMITCYS 345
Cdd:cd14967  160 -----------------------------------------------------------VLVSSVISFFIPLLIMIVLYA 180
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 346 LIVFRMRKtnltksRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLpwdhMSIALASANSCFNPFLYAL 425
Cdd:cd14967  181 RIFRVARR------ELKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDCVPPILYA----VFFWLGYLNSALNPIIYAL 250

                 ....*..
gi 564348849 426 LGKDFRK 432
Cdd:cd14967  251 FNRDFRR 257
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
24-186 2.38e-22

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 96.47  E-value: 2.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVA--GVKMKRTVNtVWFLHLTLADFLCCLSLPFSVAHLILrGHWPYGLFLCKLIPSV 101
Cdd:cd15092    1 VTIVVVYLIVCVVGLVGNCLVMYVIlrHTKMKTATN-IYIFNLALADTLVLLTLPFQGTDIFL-GFWPFGNALCKTVIAI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFDSSRa 181
Cdd:cd15092   79 DYYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVEIPTPQ- 157

                 ....*
gi 564348849 182 yDYWD 186
Cdd:cd15092  158 -DYWD 161
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
28-161 5.16e-22

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 95.59  E-value: 5.16e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15162    5 AVYTLVFVVGLPANGMALWVLLFRTKKkAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFYGNM 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYR 161
Cdd:cd15162   85 YCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVK 139
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
31-188 5.55e-22

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 95.61  E-value: 5.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  31 SLTCLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFAS 109
Cdd:cd15968    8 SFVFLLGLPLNSVVLTRCCRHTKAwTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRFLFYFNLYGS 87
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 110 VFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCgynFDSSRAYDYWDYM 188
Cdd:cd15968   88 ILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVC---YDLAPPALFPHYV 163
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
28-176 8.97e-22

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 94.87  E-value: 8.97e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVA--GVKMKrTVNTVWFLHLTLADFLCCLSLPFSVAHLILrGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15974    5 VIYLLVCAIGLSGNTLVIYVVlrYAKMK-TVTNIYILNLAVADELFMLGLPFLATQNAI-SYWPFGSFLCRLVMTVDGVN 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDllVVDDYSVCGYNF 176
Cdd:cd15974   83 QFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSD--VQPDLNTCNISW 151
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
28-185 1.32e-21

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 94.43  E-value: 1.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGV-KMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15191    5 VLYSIIFILGFLGNSLVVCVFCHqSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLTLNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFaVCGCVWVVAFVMCIPVFVYRDLLVVDDYSV--CGYNFDSSRaYDY 184
Cdd:cd15191   85 FASIFFITCMSVDRYLAVVYPLRSQRRRSWQARL-VCLLVWVLACLSSLPTFYFRDTYYIEELGVnaCIMAFPNEK-YAQ 162

                 .
gi 564348849 185 W 185
Cdd:cd15191  163 W 163
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
24-176 2.49e-21

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 93.65  E-value: 2.49e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWV--AGVKMKrTVNTVWFLHLTLADFLCCLSLPFSVAHLILRgHWPYGLFLCKLIPSV 101
Cdd:cd15087    1 VALPVIYSVICAVGLTGNTAVIYVilRAPKMK-TVTNVFILNLAIADDLFTLVLPINIAEHLLQ-QWPFGELLCKLILSI 78
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIW--CQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVD-DYSVCGYNF 176
Cdd:cd15087   79 DHYNIFSSIYFLTVMSVDRYLVVLATVRsrRMPYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVYSNElGRKSCVLSF 156
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
28-434 2.89e-21

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 93.29  E-value: 2.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGV-KMKRTVNTVWFLHLTLADFLCCLSLPF-SVAHLIlrgHWPYGLFLCKLIPSVIILN 105
Cdd:cd15179    5 TVYSIIFLLGIVGNGLVILVMGYqKKSRTMTDKYRLHLSVADLLFVLTLPFwAVDAAA---NWYFGNFLCKAVHVIYTVN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCgynfdssraydyw 185
Cdd:cd15179   82 LYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYIC------------- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 186 dymynshlpeinppdnstghvdDRTAPSSvpARDLWTattalqsqtfhtspedpfsqdsasqqphyggkpptvliatipg 265
Cdd:cd15179  149 ----------------------DRIYPED--TFELWV------------------------------------------- 161
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 266 gfpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhawtpqVAITISRLVVGFLVPFFIMITCYS 345
Cdd:cd15179  162 --------------------------------------------------------VAFRFQHILVGLVLPGLVILTCYC 185
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 346 LIVFRMRKTNLTKSRnKTLRVAVAVVTVFFVCWIPYHIVG-----ILLVITDQESALREVVLPWDHMSIALASANSCFNP 420
Cdd:cd15179  186 IIISKLSHSKGHQKR-KALKTTVILILAFFACWLPYYIGIsidtfMLLEIIKQSCEMEQTVHKWISITEALAFFHCCLNP 264
                        410
                 ....*....|....
gi 564348849 421 FLYALLGKDFRKKA 434
Cdd:cd15179  265 ILYAFLGAKFKTSA 278
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
28-188 6.52e-21

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 92.73  E-value: 6.52e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAG--VKMkRTVNTVWFLHLTLAD--FL-CCLslPFSvAHLILRGHWPYGLFLCKLIPSVI 102
Cdd:cd15095    5 LIFAIIFLVGLAGNSLVIYVVSrhREM-RTVTNYYIVNLAVTDlaFLvCCV--PFT-AALYATPSWVFGDFMCKFVNYMM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 103 ILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDY---SVCGYNFDSS 179
Cdd:cd15095   81 QVTVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYgpqTYCREVWPSK 160
                        170
                 ....*....|
gi 564348849 180 RAYD-YWDYM 188
Cdd:cd15095  161 AFQKaYMIYT 170
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
28-431 1.20e-20

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 91.73  E-value: 1.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILrgHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15181    5 LAYSLVFLLGVVGNGLVLTIlLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIA--GWVFGTFLCKLVGAIHKLNF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLlvvddysvcgynfdssraydywd 186
Cdd:cd15181   83 YCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLEV----------------------- 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 187 ymynshlpeinppdnSTGHVDDRTapssvpardlwtattalqSQTFHTspedpfsqdsasqqphyggkpptvliatipGG 266
Cdd:cd15181  140 ---------------ETSTNANRT------------------SCSFHQ------------------------------YG 156
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 267 FpvedHKSNTLNTGAFLsahtepsltasssplyahdfpddyfdqlmygNHawtpqvaitisrlVVGFLVPFFIMITCYSL 346
Cdd:cd15181  157 I----HESNWWLTSRFL-------------------------------YH-------------VVGFFLPLLIMGYCYAT 188
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 347 IVFRMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLPwDHMSIA------LASANSCFNP 420
Cdd:cd15181  189 IVVTLCQSSRRLQKQKAIRVAILVTLVFCLCWLPYNIVIFLDTLDDLKAVVKNCKLN-DLLDAAitvtesLGFSHCCLNP 267
                        410
                 ....*....|.
gi 564348849 421 FLYALLGKDFR 431
Cdd:cd15181  268 ILYAFIGVKFR 278
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
28-172 1.29e-20

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 91.74  E-value: 1.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd14991    5 PLLILEFVLGLPGNVVALWIFCFHSRtWKANTVYLFNLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNLFMLSVNR 84
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd14991   85 SASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSC 150
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
34-171 1.58e-20

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 91.40  E-value: 1.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  34 CLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFL 112
Cdd:cd15380   11 CFFGLLGNLFVLFVFLLPRRRlTIAEIYLANLAASDLVFVLGLPFWAENIRNQFNWPFGNFLCRVISGVIKANLFISIFL 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 113 LTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSV 171
Cdd:cd15380   91 VVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVPDLNI 149
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
35-172 2.79e-20

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 90.54  E-value: 2.79e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLL 113
Cdd:cd15161   12 ILAFPGNTLALWLFIHDRKsGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLFYLNMYASLYFL 91
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 114 TAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd15161   92 ACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVC 150
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
28-182 2.88e-20

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 90.59  E-value: 2.88e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd16001    5 VTYSVVFVLGLPLNGTVLWLSWCRTKRwTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLFYTNL 84
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCgYNFDSSRAY 182
Cdd:cd16001   85 YGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRTVC-YDLTSPDNF 159
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
24-432 2.97e-20

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 90.39  E-value: 2.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLW--VAGVKMKRTVNtVWFLHLTLADFLCCLSLPFSVAHLILrGHWPYGLFLCKLIPSV 101
Cdd:cd15089    1 IAITALYSVVCVVGLLGNVLVMYgiVRYTKMKTATN-IYIFNLALADALATSTLPFQSAKYLM-ETWPFGELLCKAVLSI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVyrdllvvddysvcgynfdssra 181
Cdd:cd15089   79 DYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMV---------------------- 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 182 ydywdymynshlpeinppdnstghvddrtapssvpardlwTATTalqsqtfhtspedpfsqdsasqqphyggkpptvlia 261
Cdd:cd15089  137 ----------------------------------------MAVT------------------------------------ 140
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 262 tipggfpvedhksNTLNTGAFLSAHTEPSltasssplyahdfPDDYFDQLMygnhawtpqvaiTISRLVVGFLVPFFIMI 341
Cdd:cd15089  141 -------------KTPRDGAVVCMLQFPS-------------PSWYWDTVT------------KICVFIFAFVVPILVIT 182
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 342 TCYSLIVFRMRKTNL-----TKSRN--KTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLPWdHMSIALASA 414
Cdd:cd15089  183 VCYGLMILRLRSVRLlsgskEKDRNlrRITRMVLVVVAAFIICWTPIHIFVIVWTLVDIDRRNPLVVAAL-HLCIALGYA 261
                        410
                 ....*....|....*...
gi 564348849 415 NSCFNPFLYALLGKDFRK 432
Cdd:cd15089  262 NSSLNPVLYAFLDENFKR 279
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
30-171 3.40e-20

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 90.60  E-value: 3.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  30 LSLTCLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFA 108
Cdd:cd15381    7 LWIIFVLGTIENAFVLIVFCLHKSScTVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYMNLYS 86
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564348849 109 SVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSV 171
Cdd:cd15381   87 SIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNI 149
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
29-191 5.60e-20

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 89.87  E-value: 5.60e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFA 108
Cdd:cd15339    6 FIGILCSTGLVGNILVLFTIIRSRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDTCNQFA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 109 SVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVV-DDYSVCGYNFDSSRAYdYWDY 187
Cdd:cd15339   86 CSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFrDGLESCAFNLTSPDDV-LWYT 164

                 ....
gi 564348849 188 MYNS 191
Cdd:cd15339  165 LYQT 168
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
29-172 6.28e-20

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 89.52  E-value: 6.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVA--GVKMKrTVNTVWFLHLTLADFLCCLSLPFSVAHLILrGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15971    6 IYFVVCIIGLCGNTLVIYVIlrYAKMK-TVTNIYILNLAIADELFMLGLPFLAIQVAL-VHWPFGKAICRVVMTVDGINQ 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd15971   84 FTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSC 149
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
34-171 1.80e-19

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 88.29  E-value: 1.80e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  34 CLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFL 112
Cdd:cd15189   11 CLFGLLGNLFVLLVFLLHRRRlTVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNGVIKVNLYTSIYL 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 113 LTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSV 171
Cdd:cd15189   91 LVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDLNI 149
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
28-433 3.92e-19

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 87.44  E-value: 3.92e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRghWPYGLFLCKLIPSVIILNM 106
Cdd:cd15180    5 VLYSLVFLLGLLGNGLVLAVLLQKRRNlSVTDTFILHLALADILLLVTLPFWAVQAVHG--WIFGTGLCKLAGAVFKINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCL-MVHKpiwCQNHRSVRTAFAVCGC--VWVVAFVMCIPVFVyrdllvvddysvcgynfdssrayd 183
Cdd:cd15180   83 YCGIFLLACISFDRYLsIVHA---VQMYSRKKPMLVHLSCliVWLFCLLLSIPDFI------------------------ 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 184 ywdymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliati 263
Cdd:cd15180      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 264 pggfpvedhksntlntgaFLSAHTEPSLTASsspLYAHDFPDDYFDqlmygnhaWtpQVAITISRLVVGFLVPFFIMITC 343
Cdd:cd15180  136 ------------------FLEATKDPRQNKT---ECVHNFPQSDTY--------W--WLALRLLYHIVGFLLPLAVMVYC 184
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 344 YSLIVFRMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLPWdHMSIALASANS------C 417
Cdd:cd15180  185 YTSILLRLLRSSQGFQKQRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVLDRNCGTES-RLDIALSVTSSlgyfhcC 263
                        410
                 ....*....|....*.
gi 564348849 418 FNPFLYALLGKDFRKK 433
Cdd:cd15180  264 LNPLLYAFVGVKFRRK 279
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
28-181 4.19e-19

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 87.06  E-value: 4.19e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15160    5 VVYSFVFVVGLPANCLALWVLYLQIKkENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVGFFFYTNI 84
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFvYRDLLVVD--DYSVC--GYNFDSSRA 181
Cdd:cd15160   85 YASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFL-GHDELFRDepNHTLCyeKYPMEGWQA 162
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
31-161 5.94e-19

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 86.79  E-value: 5.94e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  31 SLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFAS 109
Cdd:cd15921    8 ILIFILGLTGNSISVYVfLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVLYVNMYSS 87
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564348849 110 VFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYR 161
Cdd:cd15921   88 IYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAK 139
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
31-433 6.04e-19

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 86.72  E-value: 6.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  31 SLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFAS 109
Cdd:cd15158    8 SVITVFGLVGNGFALYVlIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYALYVNLYCS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 110 VFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFvyrdllvvddysvcgynfdssraydywdyMY 189
Cdd:cd15158   88 IYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFL-----------------------------MS 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 190 NSHLPEINppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliatipggfpv 269
Cdd:cd15158  139 GSHDTETN------------------------------------------------------------------------ 146
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 270 edhksntlNTGAFlsahtEPSLTASSsplyahdfpddyFDQLMYGNHawtpqvaitISrLVVGFLVPFFIMITCYSLIVF 349
Cdd:cd15158  147 --------KTKCF-----EPPQSNQQ------------LTKLLVLNY---------IS-LVVGFIIPFLVILICYAMIIR 191
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 350 RMRKTNLTK-----SRNKTLRVAVAVVTVFFVCWIPYHIV-GILLVITDQESALREVVLpwdHM------SIALASANSC 417
Cdd:cd15158  192 TLLKNTMKArkqqsSRKKAIRMIIIVLLAFLVSFMPYHIQrTIHLHFLSRKDSTCEEVL---YMqksvviTLCLAAANCC 268
                        410
                 ....*....|....*.
gi 564348849 418 FNPFLYALLGKDFRKK 433
Cdd:cd15158  269 FDPLLYFFSGENFRRR 284
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
24-432 6.71e-19

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 86.59  E-value: 6.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVA--GVKMKRTVNtVWFLHLTLADFLCCLSLPF-SVAHLIlrGHWPYGLFLCKLIPS 100
Cdd:cd15090    1 ITIMALYSIVCVVGLFGNFLVMYVIvrYTKMKTATN-IYIFNLALADALATSTLPFqSVNYLM--GTWPFGNILCKIVIS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 101 VIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVfvyrdllvvddysvcgynfdssr 180
Cdd:cd15090   78 IDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPV----------------------- 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 181 aydywdymynshlpeinppdnstghvddrtapssvpardLWTATTALQSQtfhtspedpfSQDSASQQPHyggkpptvli 260
Cdd:cd15090  135 ---------------------------------------MFMATTKYRQG----------SIDCTLTFSH---------- 155
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 261 atipggfpvedhksntlntgaflsahtepsltasssplyahdfPDDYFDQLMygnhawtpqvaiTISRLVVGFLVPFFIM 340
Cdd:cd15090  156 -------------------------------------------PSWYWENLL------------KICVFIFAFIMPVLII 180
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 341 ITCYSLIVFRMRKTNL-----TKSRN--KTLRVAVAVVTVFFVCWIPYHI-VGILLVITDQESALREVVlpWdHMSIALA 412
Cdd:cd15090  181 TVCYGLMILRLKSVRMlsgskEKDRNlrRITRMVLVVVAVFIVCWTPIHIyVIIKALVTIPETTFQTVS--W-HFCIALG 257
                        410       420
                 ....*....|....*....|
gi 564348849 413 SANSCFNPFLYALLGKDFRK 432
Cdd:cd15090  258 YTNSCLNPVLYAFLDENFKR 277
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
28-172 1.40e-18

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 85.59  E-value: 1.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLwVAGVKMKR--TVNTVWFLHLTLADFLCCLSLPFSVAHLilRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15175    5 AMYSVICFLGLLGNGLVI-LTYIYFKRlkTMTDIYLLNLALADILFLLTLPFWAASA--AKKWVFGEEMCKAVYCLYKMS 81
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSvRTAF---AVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd15175   82 FFSGMLLLMCISIDRYFAIVQAASAHRHRS-RAVFiskVSSLGVWVLAFILSIPELLYSGVNNNDGNGTC 150
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
28-170 1.40e-18

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 85.55  E-value: 1.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV-AGVKMKRTVNT--VWFLHLTLADFLCCL-SLPFSVAHLILRGhWPYGLFLCKLIPSVII 103
Cdd:cd15098    5 VVFGLIFCLGVLGNSLVITVlARVKPGKRRSTtnVFILNLSIADLFFLLfCVPFQATIYSLPE-WVFGAFMCKFVHYFFT 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYS 170
Cdd:cd15098   84 VSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTAS 150
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
28-194 2.25e-18

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 85.21  E-value: 2.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADF---LCCLslPFSVAHLILRgHWPYGLFLCKLIPSVII 103
Cdd:cd14971    5 LFFALIFLLGLVGNSLVILVvARNKPMRSTTNLFILNLAVADLtflLFCV--PFTATIYPLP-GWVFGDFMCKFVHYFQQ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDL--LVVDDYSVCGYNF---DS 178
Cdd:cd14971   82 VSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLrnYTPGNRTVCSEAWpsrAH 161
                        170
                 ....*....|....*.
gi 564348849 179 SRAYDYWDYMYNSHLP 194
Cdd:cd14971  162 RRAFALCTFLFGYLLP 177
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
34-163 2.42e-18

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 84.85  E-value: 2.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  34 CLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILrGHWPYGLFLCKLIPSVIILNMFASVFL 112
Cdd:cd15972   11 CVVGLGGNTLVIYVVLRYSAsESVTNIYILNLALADELFMLGLPFLAAQNAL-SYWPFGSFMCRLVMTVDAINQFTSIFC 89
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564348849 113 LTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDL 163
Cdd:cd15972   90 LTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGV 140
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
25-153 2.98e-18

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 84.76  E-value: 2.98e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  25 ASMVIlsltCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFlcclSLPFSVAHLILRGHWPYGLFLCK---LIPSV 101
Cdd:cd15110    6 VSLII----CLLGLVGNGIVLWFLGFRIRRNPFTVYILHLAIADF----TFLLCIFILSIMYIGPFNFSHSRdyvAMLIF 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 102 IILNMFA---SVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVM 153
Cdd:cd15110   78 IILFLFGyntGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWALSVLM 132
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-168 3.74e-18

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 84.41  E-value: 3.74e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMKRTVN-TVWFLHLTLADFLCCLSLPFSVAHLILRGhWPYGLFLCKLIPSVIILNM 106
Cdd:cd14999    4 TVLSLMCVVGVAGNVYTLVVMCLSMRPRASmYVYILNLALADLLYLLTIPFYVSTYFLKK-WYFGDVGCRLLFSLDFLTM 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIwCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDD 168
Cdd:cd14999   83 HASIFTLTVMSTERYLAVVKPL-DTVKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVED 143
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
28-172 4.40e-18

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 84.38  E-value: 4.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLV---LWVAGVKMKRTVNTVWFLHLTLADFLCCL-SLPFSVAHlILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15002    4 ILLGVICLLGFAGNLMVigiLLNNARKGKPSLIDSLILNLSAADLLLLLfSVPFRAAA-YSKGSWPLGWFVCKTADWFGH 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWcQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd15002   83 ACMAAKSFTIAVLAKACYMYVVNPTK-QVTIKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYLC 150
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
28-159 4.79e-18

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 84.08  E-value: 4.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLIlrghWPYGLFLCKLIPSVIILNM 106
Cdd:cd15920    5 VMYSIICIVGLLSNTLALWVfFLRQQRETSISVYMRNLALADLLLVLCLPFRVAYQN----TAGPLSFCKIVGAFFYLNM 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15920   81 YASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLF 133
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
29-172 5.60e-18

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 83.95  E-value: 5.60e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMF 107
Cdd:cd15201    6 VLILEFVLGLLGNGLALWIFCFHLKSwKSSTVYLFNLAVADFLLIICLPFRTDYYLRGKHWKFGDIPCRIVLFMLAMNRA 85
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849 108 ASVFLLTAISLDRCLMV---HKPIwcqNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd15201   86 GSIFFLTAVAVDRYFRVvhpHHRI---NSISVRKAAIIACGLWLLTIAMTVYLLTKKHLFPRGNATQC 150
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
28-159 5.70e-18

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 83.66  E-value: 5.70e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVaHLIlRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15923    5 AIYIPTFVLGLLLNILALWVFCWRLKkWTETNIYMTNLAVADLLLLISLPFKM-HSY-RRESAGLQKLCNFVLSLYYINM 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15923   83 YVSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFL 135
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
28-159 7.34e-18

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 83.59  E-value: 7.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15148    5 VFYSLIFLFGLVGNLLALWVfLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNNQWTLGPLLCKVVGNLFYMNM 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 107 FASVFLLTAISLDRCLMVHKPI----WCQNHRSVrtafAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15148   85 YISIILLGFISLDRYLKINRSSrrqkFLTRKWSI----VACGVLWAVALVGFVPMIV 137
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
33-176 8.68e-18

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 83.15  E-value: 8.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  33 TCLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRghWPYGLFLCKLIPSVIILNMFASVF 111
Cdd:cd15165   10 TFVLGLLLNLMALWVFLFKIKKwTESTIYMINLALNDLLLLLSLPFKMHSSKKQ--WPLGRTLCSFLESLYFVNMYGSIL 87
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 112 LLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDllVVDDYSVCGYNF 176
Cdd:cd15165   88 IIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHD--KPTNNTRCFHGF 150
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
29-187 1.42e-17

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 83.00  E-value: 1.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVL---WVAGVKMKRTvnTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15379    6 VYSVVFLLGLPLNAVVIgqiWATRQALSRT--TIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQFYTN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVR-TAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCgynFDSS---RA 181
Cdd:cd15379   84 LHGSILFLTCISVQRYLGICHPLASWHKKKGKkLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVC---YDLSppaRS 160

                 ....*.
gi 564348849 182 YDYWDY 187
Cdd:cd15379  161 TAYFPY 166
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
28-182 1.59e-17

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 82.73  E-value: 1.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15096    5 VIFGLIFIVGLIGNSLVILVvLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDD----YSVCGYN---FDSS 179
Cdd:cd15096   85 YASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFsseaYSYCTFLtevGTAA 164

                 ...
gi 564348849 180 RAY 182
Cdd:cd15096  165 QTF 167
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
32-172 1.86e-17

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 82.11  E-value: 1.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  32 LTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLAD--FLCCLSLPFSVAHLILRGHWPYGLflcKLIPSVIILNMFAS 109
Cdd:cd15108    9 FTCVCGMAGNGLVVWLLSCRGRRTPFCVYVLHLAVADllFLLCMASTLSLETSPLVITHDLAY---EVVRRVKYFAYTAS 85
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564348849 110 VFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd15108   86 LSLLTAISTQRCLSVLFPIWYKCHQPRHLSAVVCALLWALSLLMNVLASFFCSEFWHPDEWQC 148
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
29-188 2.61e-17

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 81.92  E-value: 2.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVA--GVKMKRTVNtVWFLHLTLADFLCCLSLPFSVAHLILRGhWPYGLFLCKLIPSVIILNM 106
Cdd:cd15091    6 VYSVVFVVGLVGNSLVMFVIirYTKMKTATN-IYIFNLALADALVTTTMPFQSTVYLMNS-WPFGDVLCKIVISIDYYNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSV--CGYNFdSSRAYDY 184
Cdd:cd15091   84 FTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSteCSLQF-PDDDYSW 162

                 ....
gi 564348849 185 WDYM 188
Cdd:cd15091  163 WDTF 166
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
28-172 3.08e-17

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 81.83  E-value: 3.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVK--MKRTVNtVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15194    5 ILYCLVFLVGAVGNAILMGALVFKrgVRRLID-IFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYIISVN 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd15194   84 MYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYC 150
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
29-187 5.19e-17

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 81.28  E-value: 5.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVAGVKMKRTVNT--VWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15376    6 ILGVEFLVAVLGNGLALWLFVTRERRPWHTgvVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFTCNL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDL-LVVDDYSVCGYNFDSSRAYDYW 185
Cdd:cd15376   86 YGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLeVERHNKTECLGTAVDSRLPTYL 165

                 ..
gi 564348849 186 DY 187
Cdd:cd15376  166 PY 167
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
32-177 9.62e-17

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 80.18  E-value: 9.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  32 LTC---LLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCclsLPFSVAHLILRGHWPYGLF-LCKLIPSVIILNMF 107
Cdd:cd15106    6 LTCiisLVGLTGNAVVLWLLGFRMRRNAFSVYILNLAAADFLF---LCCHIIDSLLRLINIFHIIsIPKILTNVMTFPYF 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 108 ASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFD 177
Cdd:cd15106   83 AGLSMLSAISTERCLSVLWPIWYRCHRPRHLSAVVCVLLWALSLLLSILEWKFCGFLFSGADSHWCQTFD 152
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
28-194 9.66e-17

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 80.25  E-value: 9.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMKRTVNT--VWFLHLTLADF---LCCLslPFSVAHLILRGhWPYGLFLCKLIPSVI 102
Cdd:cd15097    5 VVFSLIFLLGTVGNSLVLAVLLRSGQSGHNTtnLFILNLSVADLcfiLFCV--PFQATIYSLEG-WVFGSFLCKAVHFFI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 103 ILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC--GYNFDSSR 180
Cdd:cd15097   82 YLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYANSTVCmpGWEEARRK 161
                        170
                 ....*....|....
gi 564348849 181 AYDYWDYMYNSHLP 194
Cdd:cd15097  162 AMDTCTFAFGYLIP 175
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
29-180 9.89e-17

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 80.30  E-value: 9.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVAGVKMKR--TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15925    6 AYGLVCAIGLLGNLAVMYLLRNCARRapPPIDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTATVLNV 85
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFDSSR 180
Cdd:cd15925   86 YASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLLKFPSNY 159
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
32-160 1.27e-16

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 79.80  E-value: 1.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  32 LTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILrgHWPYGLFLCKLIPSVIILNMFASV 110
Cdd:cd15174    9 LIFLVGAVGNSLVVLIyTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAASS--GWVFGTFLCKVVNSMYKINFYSCM 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564348849 111 FLLTAISLDRCLMVHKPIWCQNHRSVRTAFA--VCGCVWVVAFVMCIPVFVY 160
Cdd:cd15174   87 LLLTCISVDRYIAIVQATKAHNSKNKRLLYSklVCFFVWLLSTILSLPEILF 138
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
28-163 1.30e-16

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 80.00  E-value: 1.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNG-LVLWVAGVKMKRTVNTVWFLHLTLADFLCCL-SLPFSVAHLILRGhWPYGLFLCKLIPSVIILN 105
Cdd:cd15927    5 ILFALIFLVGVLGNGtLILIFLRNKSMRNVPNIFILSLALGDLLLLLtCVPFTSTIYTLDS-WPFGEFLCKLSEFLKDTS 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDL 163
Cdd:cd15927   84 IGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHV 141
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
28-192 1.38e-16

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 79.94  E-value: 1.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKM--KRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15926    5 IVYSVVCALGLVGNLLVLYLMKSKQgwKKSSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYVTAMN 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNF-DSSRAYDY 184
Cdd:cd15926   85 MYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFpDNRGNAQF 164

                 ....*...
gi 564348849 185 WDYMYNSH 192
Cdd:cd15926  165 WLGLYHAQ 172
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
17-439 1.76e-16

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 80.21  E-value: 1.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  17 PLFKPQDIASMVILSLTCL---LGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRgHWPYGLF 93
Cdd:PHA03087  31 DLNIGYDTNSTILIVVYSTiffFGLVGNIIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILF-QWSFGEF 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  94 LCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCg 173
Cdd:PHA03087 110 ACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLIC- 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 174 ynfdssraydywdYMYnshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphygg 253
Cdd:PHA03087 189 -------------CMF---------------------------------------------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 254 kpptvliatipggfpvedhksntlntgaflsahtepsltasssplyahdfpddYFDQLMYgnhaWTPQVAITISrlVVGF 333
Cdd:PHA03087 192 -----------------------------------------------------YNNKTMN----WKLFINFEIN--IIGM 212
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 334 LVPFFIMITCYSLIVFRMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGI-----LLVITDQESALREVVLPWdHMS 408
Cdd:PHA03087 213 LIPLTILLYCYSKILITLKGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFvyslhILHFKSGCKAVKYIQYAL-HVT 291
                        410       420       430
                 ....*....|....*....|....*....|.
gi 564348849 409 IALASANSCFNPFLYALLGKDFRKKARQSVK 439
Cdd:PHA03087 292 EIISLSHCCINPLIYAFVSEFFNKHKKKSLK 322
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
35-161 2.31e-16

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 79.07  E-value: 2.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLLT 114
Cdd:cd15371   12 VLGVPSNAIILWMLFFRLRSVCTAIFYANLAISDLLFCITLPFKIVYHLNGNNWVFGETMCRIITITFYGNMYCSILLLT 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 564348849 115 AISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYR 161
Cdd:cd15371   92 CISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPFFILK 138
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
27-160 3.29e-16

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 78.88  E-value: 3.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTcllglpGNGLVLW-VAGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLiLRGHWPYGLFLCKLIPSVIIL 104
Cdd:cd15390   10 MVLVAIG------GNLIVIWiVLAHKRMRTVTNYFLVNLAVADLLiSAFNTVFNFTYL-LYNDWPFGLFYCKFSNFVAIT 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIwcQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY 160
Cdd:cd15390   83 TVAASVFTLMAISIDRYIAIVHPL--RPRLSRRTTKIAIAVIWLASFLLALPQLLY 136
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
28-156 3.55e-16

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 78.66  E-value: 3.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15368    5 VVYSLVALISIPGNLFSLWLLCFHTKpKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVLFYANM 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15368   85 YSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSP 134
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
29-179 3.83e-16

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 78.17  E-value: 3.83e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLC-CLSLPFSVAHLILrGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15061    5 FLILAIIFTIFGNLLViLAVATTRRLRTITNCYIVSLATADLLVgVLVLPLAIIRQLL-GYWPLGSHLCDFWISLDVLLC 83
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFDSS 179
Cdd:cd15061   84 TASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCYYTYDKG 156
7tmA_MrgprA cd15105
mas-related G protein-coupled receptor subtype A, member of the class A family of ...
35-172 4.58e-16

mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320233  Cd Length: 276  Bit Score: 78.25  E-value: 4.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLcKLIPSVIILNMFASVFLLT 114
Cdd:cd15105   12 LVGLTGNAIVFWLLGFRLHRNAFSVYILNLALADFLFLLCHIIDSTLLLLKVFYPNIIFL-PCFYTIMMVLYITGLSMLS 90
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 115 AISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLL--VVDDYSVC 172
Cdd:cd15105   91 AISTERCLSVLCPIWYRCRRPEHTSTVMCAVIWVLSLLICILNRYFCGFLdtKYENDSVC 150
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
28-160 8.75e-16

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 77.49  E-value: 8.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15373    5 VSYGIVFVVGLVLNILALYVFLFRTKPwNASTTYMFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRFLFYTNL 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY 160
Cdd:cd15373   85 YCSILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYF 138
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
29-189 1.01e-15

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 77.16  E-value: 1.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVAGVKMK----RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIIL 104
Cdd:cd15338    6 VFGVICFLGIIGNSIVIYTIVKKSKfrcqQTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLITALDTN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSV-CGYNFDSSRAYD 183
Cdd:cd15338   86 SQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDGSVgCALLLPNPETDT 165

                 ....*.
gi 564348849 184 YWDYMY 189
Cdd:cd15338  166 YWFTLY 171
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
28-191 1.02e-15

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 77.54  E-value: 1.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15374    5 VSYGLVFVVGLPLNATALWLFIKRMRpWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLFYANL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCgynFDSSRAYDYWD 186
Cdd:cd15374   85 YCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLC---HDTTRPEEFDH 161

                 ....*
gi 564348849 187 YMYNS 191
Cdd:cd15374  162 YVHYS 166
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
28-172 1.02e-15

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 77.42  E-value: 1.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15375    5 VMYSIIFIVGFPGNIIAIFVYLFKMRPwKSSTIIMLNLALTDLLYVTSLPFLIYYYINGESWIFGEFMCKFIRFIFHFNL 84
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd15375   85 YGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEKNNRTIC 150
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
35-156 1.14e-15

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 77.11  E-value: 1.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWVaGVKMKRT--VNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFL 112
Cdd:cd14987   12 VIGLLANSVVVWV-NLQAKRTgyETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIFSINLFGSIFF 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564348849 113 LTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd14987   91 LTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLP 134
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
24-153 1.26e-15

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 76.99  E-value: 1.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLC-CLSLPFSvAHLILRGHWPYGLFLCKLIPSV 101
Cdd:cd15051    1 IVLGVVLAVIILLTVIGNVLVcLAVAVNRRLRNLTNYFIVSLAVTDLLLgLLVLPFS-AIYELRGEWPLGPVFCNIYISL 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVM 153
Cdd:cd15051   80 DVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAV 131
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
24-172 1.46e-15

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 76.53  E-value: 1.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNT-VWFLHLTLADflCCL--SLPFsVAHLILRGHWPYglFLCKLIPS 100
Cdd:cd15164    1 LIQLIIYIPILFFGLLFNVLALWVFCCKMKKWTETrVYMINLAVAD--CCLlfSLPF-VLYFLKHSWPDD--ELCLVLQS 75
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564348849 101 VIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAfvmcIPVFVYRDLLVVDDYSVC 172
Cdd:cd15164   76 IYFINRYMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVLV----IISVSLRLAWEEQEENFC 143
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
28-179 1.62e-15

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 76.88  E-value: 1.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRgHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15155    5 AVYSVVFILGLITNCASLFVFCFRMKmRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNR-HWPFGDSLCKISGTAFLTNI 83
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFDSS 179
Cdd:cd15155   84 YGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKS 156
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
28-172 1.76e-15

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 76.32  E-value: 1.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILrgHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15176    5 VFYTIALVVGLAGNSLVVAIyAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAVN--GWVLGTAMCKITSALYTMNF 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRtaFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd15176   83 SCGMQFLACISVDRYVAITKATSRQFTGKHC--WIVCLCVWLLAILLSIPDLVFSTVRENSDRYRC 146
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
27-162 2.42e-15

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 75.97  E-value: 2.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15364    4 VVVYSVVFALGFPANCLTLWLTLLQVRRkNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYIFFCN 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRD 162
Cdd:cd15364   84 IYISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFIMRE 140
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
28-159 3.44e-15

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 75.71  E-value: 3.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLiLRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd14969    5 VYLSLIGVLGVVLNGLVIIVfLKKKKLRTPLNLFLLNLALADLLmSVVGYPLSFYSN-LSGRWSFGDPGCVIYGFAVTFL 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPiwCQNHR-SVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd14969   84 GLVSISTLAALAFERYLVIVRP--LKAFRlSKRRALILIAFIWLYGLFWALPPLF 136
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
28-188 4.25e-15

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 75.47  E-value: 4.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLW-VAGVKMKRTVNTVWFLHLTLADFLCCL-SLPFS-VAHLILRgHWPYGLFLCKLIPSVIIL 104
Cdd:cd15392    5 LMYSTIFVLAVGGNGLVCYiVVSYPRMRTVTNYFIVNLALSDILMAVfCVPFSfIALLILQ-YWPFGEFMCPVVNYLQAV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIwcQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY----RDLLVVDDYSVCGYNFDSSR 180
Cdd:cd15392   84 SVFVSAFTLVAISIDRYVAIMWPL--RPRMTKRQALLLIAVIWIFALATALPIAITsrlfEDSNASCGQYICTESWPSDT 161

                 ....*...
gi 564348849 181 AYDYWDYM 188
Cdd:cd15392  162 NRYIYSLV 169
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
28-164 4.25e-15

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 75.80  E-value: 4.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLwVAGVKMK--RTVNTVWFLHLTLADFLCCL-SLPFSVAHlILRGHWPYGLFLCKLIPSVIIL 104
Cdd:cd15048    5 VLISVLILVTVIGNLLVI-LAFIKDKklRTVSNFFLLNLAVADFLVGLvSMPFYIPY-TLTGKWPFGKVFCKAWLVVDYT 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLL 164
Cdd:cd15048   83 LCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLW 142
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
32-159 7.11e-15

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 74.60  E-value: 7.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  32 LTCLLGLPGNGLVLWVAGVKMKR--TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFAS 109
Cdd:cd15170    9 ITFLIGLPANLLAFYTFIRKVRRkpTPIDILLLNLTVSDLIFLLFLPFKMAEAASGMIWPLPYFLCPLSSFIFFSTIYIS 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564348849 110 VFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15170   89 TLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAFSHCSIVYI 138
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
29-189 8.14e-15

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 74.42  E-value: 8.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMF 107
Cdd:cd15369    6 VYTIVFVISLPLNILALVVFLRKMRvKKPAVIYMLNLACADLLFVLLLPFKIAYHFSGNDWLFGEAMCRVVTAAFYCNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 108 ASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSV--CGYNFDSSRAYDYW 185
Cdd:cd15369   86 CSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPDLGIttCHDVLNEQLLMGYY 165

                 ....
gi 564348849 186 DYMY 189
Cdd:cd15369  166 VYYF 169
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
31-159 1.37e-14

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 74.19  E-value: 1.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  31 SLTCLLGLPGNGLVLWVAgVKMK--RTVNTVWFLHLTLADFL---CCLslPFS-VAHLILRghWPYGLFLCKLIPSVIIL 104
Cdd:cd15207    8 SLIFLLCVVGNVLVCLVV-AKNPrmRTVTNYFILNLAVSDLLvgvFCM--PFTlVDNILTG--WPFGDVMCKLSPLVQGV 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 105 NMFASVFLLTAISLDR-CLMVHKPiwcQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15207   83 SVAASVFTLVAIAVDRyRAVVHPT---EPKLTNRQAFVIIVAIWVLALAIMIPQAL 135
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
31-178 1.91e-14

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 73.27  E-value: 1.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  31 SLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPF---SVAHlilrgHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15173    8 SVMFVTGLVGNSLVIVIYIFYEKlRTLTDIFLVNLAVADLLFLCTLPFwaySAAH-----EWIFGTVMCKITNGLYTINL 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFA--VCGCVWVVAFVMCIPVFVYRDLLVVDDySVCGYNFDS 178
Cdd:cd15173   83 YSSMLILTCITVDRFIVIVQATKAHNCHAKKMRWGkvVCTLVWVISLLLSLPQFIYSEVRNLSS-KICSMVYPP 155
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
28-172 2.01e-14

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 73.29  E-value: 2.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLIlrGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15187    5 VLYCLLFVFGLLGNSLVIWVlVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLL--DQWVFGNAMCKIVSGAYYIGF 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd15187   83 YSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQC 148
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
28-167 2.02e-14

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 73.08  E-value: 2.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLW-VAGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLILrGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15001    4 IVYVITFVLGLIGNSLVIFvVARFRRMRSVTNVFLASLATADLLlLVFCVPLKTAEYFS-PTWSLGAFLCKAVAYLQLLS 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 106 MFASVFLLTAISLDRCLMVHKP----IWCQNHRSVRTAfavcGCVWVVAFVMCIPVFVYRDLLVVD 167
Cdd:cd15001   83 FICSVLTLTAISIERYYVILHPmkakSFCTIGRARKVA----LLIWILSAILASPVLFGQGLVRYE 144
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
27-162 2.12e-14

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 73.26  E-value: 2.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILrGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15154    4 LVGYSLLFPVGLLLNAVALWVFVRYLRlHSVVSIYMCNLALSDLLFTLSLPLRIYYYAN-HYWPFGNFLCQFSGSIFQMN 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRD 162
Cdd:cd15154   83 MYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHS 139
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
29-156 3.46e-14

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 72.96  E-value: 3.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRgHWPYGLFLCKLIPSVIILNMF 107
Cdd:cd15156    6 VFSMVFVLGLIANCVAIYIFMCTLKvRNETTTYMINLAISDLLFVFTLPFRIFYFVQR-NWPFGDLLCKISVTLFYTNMY 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564348849 108 ASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15156   85 GSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLP 133
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
24-159 3.77e-14

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 72.52  E-value: 3.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVI 102
Cdd:cd15199    1 IAYASLLILEFGLGLPGNAIALWTFIFRLKVwKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLFML 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 103 ILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15199   81 SLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLL 137
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
24-184 3.78e-14

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 72.39  E-value: 3.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAgVKMK--RTVNTVWFLHLTLADFLCCLSLPFSVAHLIlrGHWPYGLFLCKLIPSV 101
Cdd:cd15182    1 AFLPVFYYLVFLLSLLGNGLVLWIL-VKYEklKTLTNIFILNLAISDLLFTFTLPFWASYHS--SGWIFGEILCKAVTSI 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVD-DYSVCGYNFDSSR 180
Cdd:cd15182   78 FYIGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSDeDGSLCEYSSIKWK 157

                 ....
gi 564348849 181 AYDY 184
Cdd:cd15182  158 LGYY 161
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
37-156 3.88e-14

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 72.45  E-value: 3.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  37 GLPGNGLVLWVAGVKMKRTVNTVWFL-HLTLADFLCCLSLPFSVAHLiLRGHWPYGLFLCKLIPSVIILNMFASVFLLTA 115
Cdd:cd15152   14 GLIGNVLALWVFYAYVKETKRAVIFMiNLAIADLLQVLSLPLRIFYY-LNKSWPFGKFLCMFCFYLKYVNMYASIYFLVC 92
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 564348849 116 ISLDRCLMVHKPI-WCQNHRSVRTAFAVCGcvWVVAFVMCIP 156
Cdd:cd15152   93 ISVRRCLYLIYPFrYNDCKRKCDVYISIAG--WLVVCVGCLP 132
7tmA_MrgprF cd15109
mas-related G protein-coupled receptor subtype F, member of the class A family of ...
29-155 4.06e-14

mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320237  Cd Length: 274  Bit Score: 72.25  E-value: 4.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLpfSVAHLILRGHW--PYGLFLCKLIPSVIILNM 106
Cdd:cd15109    6 IFLLLCLCGLVGNGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSK--AVFSILNTGGFlgTFADYIRSVSRILGLCTF 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAF-VMCI 155
Cdd:cd15109   84 LTGVSLLPAISIERCVSVIFPTWYWRRRPKRLSAVVCALLWMLSLlVTCI 133
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
35-161 4.47e-14

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 72.52  E-value: 4.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVaHLILRGHWPYGLFLCKLIPSVIILNMFASVFLL 113
Cdd:cd15153   12 IPGLLANSAALWVlCRFISKKNKAIIFMINLAVADLAHVLSLPLRI-HYYIQHTWPFGRFLCLLCFYLKYLNMYASICFL 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564348849 114 TAISLDRCLMVHKPIWCQNHRSvRTAFAVCGCVWVVAFVMCIPVFVYR 161
Cdd:cd15153   91 TCISIQRCFFLLHPFKARDWKR-RYDVGISAAVWIVVGLACLPFPLLR 137
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
28-182 6.71e-14

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 71.98  E-value: 6.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLiLRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15083    5 IFILIIGLIGVVGNGLVIYAfCRFKSLRTPANYLIINLAISDFLmCILNCPLMVISS-FSGRWIFGKTGCDMYGFSGGLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSV-CGYNF----DSSR 180
Cdd:cd15083   84 GIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGLLTsCSFDYlsrdDANR 163

                 ..
gi 564348849 181 AY 182
Cdd:cd15083  164 SY 165
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
28-432 7.22e-14

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 71.67  E-value: 7.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLipSVIIL-- 104
Cdd:cd15922    5 VFLSLVFLGGFLLNSFSLWIFWFRIKQwSSGTILQFNLALSDAIITPAAPLLIAYFSLGSHWPFGQFLCQL--KVFLLst 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWcqNHRSVRTAF--AVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCgynfdssray 182
Cdd:cd15922   83 HMYGSIYFLMLISIHRYVTVVHYNW--KSLWKKKSFmkKLCLGVWLLLFVQGLPFFFVLKTSVIDGKTKC---------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 183 dywdymynshlpeinppdnstghvddrtapssvpardlwtattalqsqtfhtspedpfsqdsasqqphyggkpptvliat 262
Cdd:cd15922      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 263 ipggfpvedhksntlntgafLSAHTepsltasssplyaHDFPDDYFdqlmygnhawtpqvAITISRLVVGFLVPFFIMIT 342
Cdd:cd15922  151 --------------------LSIHQ-------------SELSLLYF--------------VWNFVLLILGFLLPFGVSLT 183
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 343 CYSLI---VFRMRKTNLTK--SRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLPWD----HMSIALAS 413
Cdd:cd15922  184 CYALLgasIAKMNSNNARGraMKAKSLQMIGISLVIFIICFVPLHVTRTVGVVVKLFYPESCTLLHKVevayYISWVLTG 263
                        410
                 ....*....|....*....
gi 564348849 414 ANSCFNPFLYALLGKDFRK 432
Cdd:cd15922  264 VNCCLDPLLYCFASEKFRK 282
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
35-164 9.60e-14

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 71.34  E-value: 9.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWVaGVKMKRTVNTVWF--LHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFL 112
Cdd:cd14988   12 VVGLVENVLVIWV-NWHRWGSKNLVNLyiLNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYFYFANMYSSIFF 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564348849 113 LTAISLDR--CLMVHKPIWCQNHRSVRtaFAVCGCVWVVAFVMCIPVFVYRDLL 164
Cdd:cd14988   91 LTCLSVDRylTLTSSSPFWQQHQHRIR--RALCAGIWVLSAIIPLPEVVHMQLL 142
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
28-160 1.78e-13

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 70.58  E-value: 1.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV--AGVKMKRTVNTVWFLHLTLADFLCCLSLPF---SVAHlilrgHWPYGLFLCKLIPSVI 102
Cdd:cd15188    5 VFYTLVFLLGLAGNLLLFVVllLYVPKKKKMTEVYLLNLAVSDLLFLVTLPFwamYVAW-----HWVFGSFLCKFVSTLY 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849 103 ILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY 160
Cdd:cd15188   80 TINFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVF 137
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
29-172 2.54e-13

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 70.19  E-value: 2.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLiLRGhWPYGLFLCKLIPSVIILNMF 107
Cdd:cd15177    6 VYLVVFVLGLVGNGLVLAThTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAET-LQG-WIFGNAMCKLIQGLYAINFY 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 108 ASVFLLTAISLDRCL-MVHKPIWCQ-NHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd15177   84 SGFLFLTCISVDRYVvIVRATSAHRlRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSSC 150
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
29-188 2.59e-13

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 70.18  E-value: 2.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVAGVKMKR-TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMF 107
Cdd:cd15200    6 VLGIEFVLGLVGNGIALFIFCFHRRPwKSNTMYLLSLVVADFFLIINLPFRIDYYLRNEVWRFGATACQVNLFMLSMNRT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 108 ASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVyrdLLVVDDYSVC-GYNFDS-SRAYDYW 185
Cdd:cd15200   86 ASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLLL---LDHVQSNSTClSYDHGTdPSASDRW 162

                 ...
gi 564348849 186 DYM 188
Cdd:cd15200  163 HRI 165
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
26-160 3.19e-13

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 69.65  E-value: 3.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  26 SMVILSLTCLLGLPGNGLVLwVAGVKMKRTVN-TVWFL-HLTLADFL-CCLSLPFSVAHLILRGHWPYGLFLCKLIPSVI 102
Cdd:cd15052    3 AALLLLLLVIATIGGNILVC-LAISLEKRLQNvTNYFLmSLAIADLLvGLLVMPLSILTELFGGVWPLPLVLCLLWVTLD 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849 103 ILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY 160
Cdd:cd15052   82 VLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVL 139
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
24-171 3.42e-13

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 70.01  E-value: 3.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVA-GVKMKRTVNTVWFLHLTLADFLC-CLSLPFSVAHLILRGHWPYGLFLCKLIPSV 101
Cdd:cd14997    1 VLVSVVYGVIFVVGVLGNVLVGIVVwKNKDMRTPTNIFLVNLSVADLLVlLVCMPVALVETWAREPWLLGEFMCKLVPFV 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVF---VYRDLLVVDDYSV 171
Cdd:cd14997   81 ELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLfitEFKEEDFNDGTPV 153
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
27-153 3.62e-13

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 69.73  E-value: 3.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLT-CLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLILRGHWPYGLFLCKLIpsVIIL 104
Cdd:cd15107    3 MNFLSIIiALVGLAGNAIVLWLLGFHMHRNAFSVYILNLAGADFLfLCTQIVFSLEIVLQFHSIDIHIPLFLLT--VTMF 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVM 153
Cdd:cd15107   81 AYLAGLSMITAISIERCLSVMWPIWYHCQRPRHTSAVICTLLWVLSLLL 129
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
18-149 3.87e-13

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 69.44  E-value: 3.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  18 LFKPqdiaSMVILSLTclLGLPGNGLVLWVAGVKM-KRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCK 96
Cdd:cd15366    1 LFPP----TLYIIVIV--LGLPTNCLALWAAYLQVrQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCK 74
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564348849  97 LIPSVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVV 149
Cdd:cd15366   75 LFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAI 127
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
36-153 4.57e-13

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 69.36  E-value: 4.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  36 LGLPGNGLVLWV--AGVKMKRTVNtVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLL 113
Cdd:cd15157   13 LGVVGNGLSIYVflQPSKKKTSVN-IFMLNLAVSDLMFVSTLPFRADYYLMGSHWVFGDIACRIMSYSLYVNMYCSIYFL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 564348849 114 TAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVvaFVM 153
Cdd:cd15157   92 TVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWI--FVM 129
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
35-171 6.63e-13

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 69.06  E-value: 6.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWVAGVKMKRTVNTVWFL-HLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLL 113
Cdd:cd15370   12 VVGLPSNAMALWVFLFRTKKKHPAVIYMaNLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFFYGNMYCSILFM 91
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849 114 TAISLDRCLMVHKPIwCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSV 171
Cdd:cd15370   92 TCLSVQRYWVIVNPM-SHSRKKANIAIGISLAIWLLILLVTIPLYLVKQTVFIPALDI 148
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
30-163 7.69e-13

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 68.94  E-value: 7.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  30 LSLTCLLGLPGNGLV---LWVAGVKMKRtVNTvWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd14986    7 LGVLFVFTLVGNGLVilvLRRKRKKRSR-VNI-FILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGL 84
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRsvRTAFAVCGCVWVVAFVMCIP---VFVYRDL 163
Cdd:cd14986   85 FASTYILVSMSLDRYQAIVKPMSSLKPR--KRARLMIVVAWVLSFLFSIPqlvIFVEREL 142
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
24-172 1.07e-12

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 68.31  E-value: 1.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLIlRGHWPYGLFLCKLIPSVI 102
Cdd:cd15166    1 IAALVFYSFIFIIGLFVNITALWVfSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYA-KDEWPFGDYFCRILGALT 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564348849 103 ILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP-VFVYRDLLVVDDYSVC 172
Cdd:cd15166   80 VFYPSIALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPlLFLYEDPDKASNFTTC 150
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
24-176 1.63e-12

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 67.84  E-value: 1.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCL-SLPFSVAHLILRgHWPYGLFLCKLIPSV 101
Cdd:cd14992    1 IILGVALVVIILVSVVGNFIVIAAlARHKNLRGATNYFIASLAISDLLMALfCTPFNFTYVVSL-SWEYGHFLCKIVNYL 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNF 176
Cdd:cd14992   80 RTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIF 154
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
32-156 2.08e-12

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 67.41  E-value: 2.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  32 LTCLLGLPGNGLVLWVAGVKMKRTVN-TVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASV 110
Cdd:cd15967    9 LVFVVGLVGNVWGLKSLLANWKKLGNiNVFVLNLGLADLLYLLTLPFLVVYYLKGRKWIFGQVFCKITRFCFNLNLYGSI 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564348849 111 FLLTAISLDRCLMVHKPIW----CQNHRSVRTAFAvcgcVWVVAFVMCIP 156
Cdd:cd15967   89 GFLTCISVYRYLAIVHPMRvmgrITTTHSVVISAL----VWLLVVIQSLP 134
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
28-160 3.37e-12

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 66.70  E-value: 3.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPF-SVAHlilRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15172    5 VIYSLICVVGLIGNSLVVITyAFYKRTKSMTDVYLLNMAIADILFVLTLPFwAVYE---AHQWIFGNFSCKLLRGIYAIN 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFA--VCGCVWVVAFVMCIPVFVY 160
Cdd:cd15172   82 FYSGMLLLACISVDRYIAIVQATKSFRLRSRTLAYSklICAAVWLLAILISLPTFIF 138
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
35-158 4.42e-12

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 67.73  E-value: 4.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLIlrGHWPYGLFLCKLIPSVIILNMFASVFLLT 114
Cdd:PHA02638 110 ILGLFGNAAIIMILFCKKIKTITDIYIFNLAISDLIFVIDFPFIIYNEF--DQWIFGDFMCKVISASYYIGFFSNMFLIT 187
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564348849 115 AISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVF 158
Cdd:PHA02638 188 LMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAY 231
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
28-163 5.08e-12

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 66.33  E-value: 5.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15367    5 VVYILVLVVGLPANCLSLYYGYLQIKaKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHDNWTYSELLCKICGILLYENI 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDL 163
Cdd:cd15367   85 YISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTCVFFFLHGEI 141
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
24-156 9.68e-12

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 64.98  E-value: 9.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLwVAGVKMK--RTVNTVWFLHLTLADFL-CCLSLPFSVAhLILRGHWPYGLFLCKLIPS 100
Cdd:cd15210    1 YFAAVWGIVFMVVGVPGNLLTV-LALLRSKklRTRTNAFIINLSISDLLfCAFNLPLAAS-TFLHQAWIHGETLCRVFPL 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 101 VIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15210   79 LRYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLP 134
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
32-160 1.52e-11

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 64.93  E-value: 1.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  32 LTCLLGLPGNGLVLWVAGVKMKRTVN-TVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASV 110
Cdd:cd15377    9 LVFITGFLGNSVAIWMFVFHMKPWSGiSVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSI 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564348849 111 FLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY 160
Cdd:cd15377   89 LFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFY 138
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
28-158 1.52e-11

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 64.67  E-value: 1.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCC-LSLPFSVAHLILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15053    5 LFLLLLPLLTVFGNVLViMSVFRERSLQTATNYFIVSLAVADLLVAiLVMPFAVYVEVNGGKWYLGPILCDIYIAMDVMC 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVF 158
Cdd:cd15053   85 STASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLL 137
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
28-160 1.55e-11

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 64.85  E-value: 1.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLIlrGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15186    5 IFYSLVFAFGLVGNLLVvLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLI--NEWGLHNAMCKLTTAFFFIGF 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY 160
Cdd:cd15186   83 FGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMF 136
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
31-172 2.31e-11

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 64.38  E-value: 2.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  31 SLTCLLGLPGNGLVLWVAGvKMKRTVNTVWFL--HLTLADFLCCLS-LPFSVAHLILRGHWPYGLFLCKLIPSVIILNMF 107
Cdd:cd15394    8 SLVVLVGVVGNYLLIYVIC-RTKKMHNVTNFLigNLAFSDMLMCATcVPLTLAYAFEPRGWVFGRFMCYFVFLMQPVTVY 86
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 108 ASVFLLTAISLDRCLMVHKPIwcQNHRSVRTAFAVCGCVWVVAFVMCIPVFV--YRDLLVVDDYSVC 172
Cdd:cd15394   87 VSVFTLTAIAVDRYYVTVYPL--RRRISRRTCAYIVAAIWLLSCGLALPAAAhtYYVEFKGLDFSIC 151
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
35-163 2.39e-11

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 64.45  E-value: 2.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLW-VAGVKMKRTVNTVWFLHLTLADFLCCL-SLPFSVAHLILRgHWPYGLFLCKLIPSVIILNMFASVFL 112
Cdd:cd15202   12 VFSLFGNVLVCWiIFKNQRMRTVTNYFIVNLAVADIMITLfNTPFTFVRAVNN-TWIFGLFMCHFSNFAQYCSVHVSAYT 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564348849 113 LTAISLDRCLMVHKPIWCQNHRSvRTAFAVCGcVWVVAFVMCIPVFVYRDL 163
Cdd:cd15202   91 LTAIAVDRYQAIMHPLKPRISKT-KAKFIIAV-IWTLALAFALPHAICSKL 139
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
26-159 2.41e-11

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 64.05  E-value: 2.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  26 SMVILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLC-CLSLPFSVAHLILRgHWPYGLFLCKLIPSVII 103
Cdd:cd15063    3 SLLVLTFLNVLVVLGNLLVIAAVLCSRKlRTVTNLFIVSLACADLLVgTLVLPFSAVNEVLD-VWIFGHTWCQIWLAVDV 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15063   82 WMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLV 137
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
28-159 2.61e-11

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 64.39  E-value: 2.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTV--WFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIIL 104
Cdd:cd15147    5 IVYSIIFVLGLIANCYVLWVfARLYPSKKLNEIkiFMVNLTIADLLFLITLPFWIVYYHNEGNWILPKFLCNVAGCLFFI 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15147   85 NTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLF 139
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
26-178 2.66e-11

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 63.99  E-value: 2.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  26 SMVILSLTCLLGLPGNGLVLW--VAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHlILRGHWPYGLFLCKLIPSVII 103
Cdd:cd14983    3 SLMVYVLTILLGLPSNLLALYafVNRARLRLTPNVIYMINLCLSDLVFILSLPIKIVE-ALSSAWTLPAVLCPLYNLAHF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLV-------VDDYSVCGYNF 176
Cdd:cd14983   82 STLYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVIFHVTLVFILETSGGtldintpVGNSSTCYENF 161

                 ..
gi 564348849 177 DS 178
Cdd:cd14983  162 TP 163
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
35-168 2.85e-11

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 63.97  E-value: 2.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCL-SLPFSVAHLILRgHWPYGLFLCKLIPSVIILNMFASVFL 112
Cdd:cd15393   12 LVAVVGNFLVIWVvAKNRRMRTVTNIFIANLAVADIIIGLfSIPFQFQAALLQ-RWVLPRFMCPFCPFVQVLSVNVSVFT 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 113 LTAISLDRCLMVHKPIwCQNHRSVRTAFAVCGcVWVVAFVMCIPV-FVYRDLLVVDD 168
Cdd:cd15393   91 LTVIAVDRYRAVIHPL-KARCSKKSAKIIILI-IWILALLVALPVaLALRVEELTDK 145
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
25-163 3.17e-11

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 63.56  E-value: 3.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  25 ASMVILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLILRgHWPYGLFLCKLIPSVI 102
Cdd:cd15206    2 LIIPLYSVIFLLAVVGNILVIVTlVQNKRMRTVTNVFLLNLAVSDLLlAVFCMPFTLVGQLLR-NFIFGEVMCKLIPYFQ 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564348849 103 ILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDL 163
Cdd:cd15206   81 AVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNL 141
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
31-167 3.31e-11

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 64.07  E-value: 3.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  31 SLTCLLGLPGNGLVLWVAgVKMK--RTVNTVWFLHLTLADFLC-CLSLPFSVAHLILrGHWPYGLFLCKLIPSVIILNMF 107
Cdd:cd15399    8 CSIILLGVVGNSLVIYVV-IKFKnmRTVTNFFIANLAVADLMVnTLCLPFTLVYTLL-DEWKFGAVLCHLVPYAQALAVH 85
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564348849 108 ASVFLLTAISLD--RCLMVHkpiwCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVD 167
Cdd:cd15399   86 VSTVTLTVIALDrhRCIVYH----LESKISKKISFLIIGLTWAASALLASPLAIFREYSVIE 143
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
27-167 3.73e-11

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 63.90  E-value: 3.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVLWVAgVKMKR--TVNTVWFLHLTLAD-FLCCLSLPFSVAHLILrGHWPYGLFLCKLIPSVII 103
Cdd:cd15389    4 IVAYSIIIVISLFGNSLVCHVI-FKNKRmhTATNLFIVNLAVSDiLITLLNTPFTLVRFVN-STWVFGKIMCHLSRFAQY 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIwcQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVD 167
Cdd:cd15389   82 CSVYVSTLTLTAIALDRHRVILHPL--KPRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFE 143
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
31-172 3.89e-11

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 63.58  E-value: 3.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  31 SLTCLLGLPGNGLVL--WVAGVKMKRTVNtVWFLHLTLAD--FLCCL-SLPFSVAHlilrGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15378    8 SIEFVLGFIGNTIVIlgYIFCLKNWKSSN-IYLFNLSVSDlaFLCTLpMLVYSYSN----GQWLFGDFLCKSNRYLLHAN 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPI---WCQNHRSvrtAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd15378   83 LYSSILFLTFISIDRYLLIKYPFrehILQKKRS---AVAISLAIWVLVTLELLPILTFIGPNLKDNVTKC 149
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
28-156 4.23e-11

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 63.62  E-value: 4.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMF 107
Cdd:cd15924    5 VLYTVIFFAGILLNGLAMWIFFHIPSKSSFIIYLKNTVVADLLMILTFPFKILSDAGLGPWQLRTFVCRVTSVLFYFTMY 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564348849 108 ASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15924   85 TSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLP 133
7tmA_MrgprG cd15111
mas-related G protein-coupled receptor subtype G, member of the class A family of ...
35-148 5.29e-11

mas-related G protein-coupled receptor subtype G, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320239  Cd Length: 263  Bit Score: 62.88  E-value: 5.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLAD--FLCClSLPFSVAHLILrGHWPYGLFlcklipSVIILNMFASVFL 112
Cdd:cd15111   12 LAGLVGNGLVLWHLGFHIKKGPFSNYLLHLAAADflFLSC-QVGFSIAQAAL-GSEDTLYF------VVTFLWFAAGLWL 83
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 564348849 113 LTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWV 148
Cdd:cd15111   84 LAAFSVERCLSYLFPACCQGCRPRWTSAVLCAVVWV 119
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
28-189 1.70e-10

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 61.88  E-value: 1.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVwFLHLTLADFLCCLS-LPFSVAHLI-----LRGHWPYGLFLCKLIPS 100
Cdd:cd14978    5 YVLPVICIFGIIGNILNLVVlTRKSMRSSTNVY-LAALAVSDILVLLSaLPLFLLPYIadyssSFLSYFYAYFLPYIYPL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 101 VIILNMfASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDD------YSVCGY 174
Cdd:cd14978   84 ANTFQT-ASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENcnnnsyYYVIPT 162
                        170
                 ....*....|....*
gi 564348849 175 NFDSSRAYdYWDYMY 189
Cdd:cd14978  163 LLRQNETY-LLKYYF 176
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
27-185 1.80e-10

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 61.48  E-value: 1.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWF-LHLTLADFLCCLslpFSV-AHLILR-GHWPYG-LFLCKLIPSVI 102
Cdd:cd15196    4 IAVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFiLHLSVADLLVAL---FNVlPQLIWDiTYRFYGgDLLCRLVKYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 103 ILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGcVWVVAFVMCIP-VFVYRDLLVVDDYSVCGYNFDSS-- 179
Cdd:cd15196   81 VVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAI-AWVLSLLLSIPqLFIFSYQEVGSGVYDCWATFEPPwg 159

                 ....*..
gi 564348849 180 -RAYDYW 185
Cdd:cd15196  160 lRAYITW 166
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
32-163 1.84e-10

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 61.64  E-value: 1.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  32 LTCLLGLPGNGLVLwVAGVKMK--RTVNTVWFLHLTLADFLCCL-SLPFSVAHLILRGhWPYGLFLCKLIPSVIILNMFA 108
Cdd:cd15208    9 LVFIVGLVGNVLVC-FAVWRNHhmRTVTNYFIVNLSLADFLVIIiCLPATLLVDVTET-WFFGQVLCKIIPYLQTVSVSV 86
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 109 SVFLLTAISLDRCLMVHKPI-WCQNHRSVRTAFAVcgcVWVVAFVMCIPVFVYRDL 163
Cdd:cd15208   87 SVLTLSCIALDRWYAICHPLmFKSTAKRARVSILI---IWIVSLLIMIPQAIVMEC 139
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
24-167 2.55e-10

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 61.36  E-value: 2.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKM-KRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPS-- 100
Cdd:cd14996    1 VALPIIYSFLFVTGVFGNLLSLWVFLTKIsKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFYWKYQSTQCRIANFfg 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 101 --VIILNMFASVFLLTAISLDR--CLMVH------KPIW--------CQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRD 162
Cdd:cd14996   81 tlVIHVSMCVSILILSWIAISRyaTLMKHdsatqkQSCYekifyghfLKRFRQPKFARYLCIYIWGVVLCIIIPVVVYYS 160

                 ....*
gi 564348849 163 LLVVD 167
Cdd:cd14996  161 VREAD 165
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
28-172 2.76e-10

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 60.81  E-value: 2.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLwvAGVKMKRTVNTV---WFLHLTLADFL-CCLSLPFSVAHlILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15064    5 VLLSLIILATILGNALVI--AAILLTRKLHTPanyLIASLAVADLLvAVLVMPLSAVY-ELTGRWILGQVLCDIWISLDV 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd15064   82 TCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSEDPSEC 150
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
28-156 2.91e-10

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 60.75  E-value: 2.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCCLS-LPFSVAHLiLRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15329    5 IVLLIIILGTVVGNALViIAVCLVKKLRTPSNYLIVSLAVSDLLVALLvMPLAIIYE-LSGYWPFGEILCDVWISFDVLL 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15329   84 CTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIP 134
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
41-156 2.98e-10

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 60.96  E-value: 2.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  41 NGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLLTAISLDR 120
Cdd:cd15969   18 NGLAVWIFFHIRNKTSFIFYLKNIVIADLLMTLTFPFKIIQDSGLGPWNFNFFLCRYTSVLFYASMYTSIVFLGLISLDR 97
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 564348849 121 CLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15969   98 YLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLP 133
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
24-175 3.43e-10

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 60.43  E-value: 3.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVlwVAGVKMKRTVNTV--WFL-HLTLADFLC-CLSLPFSVAHLILrGHWPYGLFLCKLIP 99
Cdd:cd15059    1 VAISSIVSVVILLIIVGNVLV--IVAVLTSRKLRAPqnWFLvSLAVADILVgLLIMPFSLVNELM-GYWYFGSVWCEIWL 77
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849 100 SVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFV--YRDLLVVDDYSVCGYN 175
Cdd:cd15059   78 ALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFgwKDEQPWHGAEPQCELS 155
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
27-162 3.54e-10

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 60.54  E-value: 3.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVLWVAGV-KMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15012    3 IILYTLVFCCCFFGNLLVILVVTShRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLS 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRD 162
Cdd:cd15012   83 YTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQ 139
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
29-157 3.70e-10

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 60.91  E-value: 3.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLwvAGV----KMKRTVNTVWFLHLTLAD-FLCCLSLPFSVAHLILrGHWPYGLFlCKLIPSVII 103
Cdd:cd15057    6 ILYLLVLLTLLGNALVI--AAVlrfrHLRSKVTNYFIVSLAVSDlLVAILVMPWAAVNEVA-GYWPFGSF-CDVWVSFDI 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMC-IPV 157
Cdd:cd15057   82 MCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISfIPV 136
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
24-156 4.21e-10

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 60.14  E-value: 4.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADF-LCCLSLPFSVAHLILrGHWPYGLFLCKLIPSV 101
Cdd:cd15060    1 VVTTILLSVIIAFTIVGNILViLSVFTYRPLRIVQNFFIVSLAVADLaVAIFVLPLNVAYFLL-GKWLFGIHLCQMWLTC 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15060   80 DILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVP 134
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
326-433 4.49e-10

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 60.49  E-value: 4.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 326 ISRLVVGFLVPFFIMITCYSLIVF------------------RMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGIL 387
Cdd:cd15195  169 FFTMILSFVIPLIITVTCYLLILFeiskmakrardtpisnrrRSRTNSLERARMRTLRMTALIVLTFIVCWGPYYVLGLW 248
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 564348849 388 LVItDQESALRevVLPW-DHMSIALASANSCFNPFLYALLGKDFRKK 433
Cdd:cd15195  249 YWF-DKESIKN--LPPAlSHIMFLLGYLNPCLHPIIYGVFMKEIRNW 292
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
27-159 5.66e-10

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 60.69  E-value: 5.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLIlrGHWPYGLFLCKLIPSVIILNM 106
Cdd:PHA02834  32 IVFYILLFIFGLIGNVLVIAVLIVKRFMFVVDVYLFNIAMSDLMLVFSFPFIIHNDL--NEWIFGEFMCKLVLGVYFVGF 109
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNhRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:PHA02834 110 FSNMFFVTLISIDRYILVVNATKIKN-KSISLSVLLSVAAWVCSVILSMPAMV 161
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
29-157 5.92e-10

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 60.31  E-value: 5.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLwVAGVKMKR--TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15959    6 LLSLAILVIVGGNLLVI-VAIAKTPRlqTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCV 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVV-AFVMCIPV 157
Cdd:cd15959   85 TASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAIsAAISFLPI 136
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
28-160 6.03e-10

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 59.68  E-value: 6.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVlwVAGVKMKRTVNTV--WFL-HLTLADFLC-CLSLPFSVAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15067    4 VVLSLFCLVTVAGNLLV--ILAVLRERYLRTVtnYFIvSLAVADLLVgSIVMPFSILHEMTGGYWLFGRDWCDVWHSFDV 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY 160
Cdd:cd15067   82 LASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAW 138
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
36-163 6.99e-10

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 59.94  E-value: 6.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  36 LGLPGNGLVLWVA-GVKMKRTVNTVWFLHLTLADFLCCLS-LPFSVAHLILRGhWPYGLFLCKLIPSVIILNMFASVFLL 113
Cdd:cd15123   13 VGILGNAILIKVFfKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIADT-WLFGRIGCKLLSFIQLTSVGVSVFTL 91
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564348849 114 TAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDL 163
Cdd:cd15123   92 TVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDL 141
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
24-155 7.22e-10

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 59.95  E-value: 7.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWV---AGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLILRGHWPYGLFLCKLIP 99
Cdd:cd14981    1 GESPAPPALMFVFGVLGNLLALIVlarSSKSHKWSVFYRLVAGLAITDLLgILLTSPVVLAVYASNFEWDGGQPLCDYFG 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 100 SVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCI 155
Cdd:cd14981   81 FMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIAS 136
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
27-149 1.23e-09

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 59.02  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVLWVAGVKMKRTVN-TVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15365    4 PFVYIFVIVISIPSNCISLYVSCLQIRKKNElGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLLYTN 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVV 149
Cdd:cd15365   84 FYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLL 127
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
26-157 1.47e-09

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 59.00  E-value: 1.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  26 SMVILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLC-CLSLPFSvAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15058    3 LLLLLALIILAIVVGNLLVIIAIARTSRlQTMTNIFITSLACADLVMgLLVVPLG-ATIVVTGKWQLGNFWCELWTSVDV 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIwcqNHRSV----RTAFAVCgCVWVV-AFVMCIPV 157
Cdd:cd15058   82 LCVTASIETLCVIAVDRYIAITRPL---RYQVLltkrRARVIVC-VVWIVsALVSFVPI 136
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
24-159 1.50e-09

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 58.99  E-value: 1.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWvAGVKMKRTVNTVW--FLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSV 101
Cdd:cd15384    1 LLKIVVLAVMFVISFIGNLLTII-QIYRLRRSRRTIYslLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYL 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIwCQNH--RSVRTAFAVCgcvWVVAFVMCIPVFV 159
Cdd:cd15384   80 QVFGLYLSTYITVLISLDRCVAILYPM-KRNQapERVRRMVTVA---WILSPIFSIPQAV 135
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
28-175 1.53e-09

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 58.65  E-value: 1.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCC-LSLPFSVAHLILrGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15062    5 VALGAFILFAIGGNLLViLSVACNRHLRTPTHYFIVNLAVADLLLSfTVLPFSATLEVL-GYWAFGRIFCDVWAAVDVLC 83
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCI-PVFVYRDLLVVDDySVCGYN 175
Cdd:cd15062   84 CTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIgPLLGWKEPAPADE-QACGVN 153
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
29-163 3.03e-09

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 57.99  E-value: 3.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGN-GLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMF 107
Cdd:cd15124    6 VYGIIILIGLIGNiTLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLTSVG 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 108 ASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDL 163
Cdd:cd15124   86 VSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDL 141
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
28-160 3.69e-09

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 57.67  E-value: 3.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFL---CCLslPFSVAHLILR-GHWPYGLFLCKLIPSVI 102
Cdd:cd15204    5 VVYVLIMLVCGVGNLLLIAVlARYKKLRTLTNLLIANLALSDFLvavFCL--PFEMDYYVVRqRSWTHGDVLCAVVNYLR 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849 103 ILNMFASVFLLTAISLDRCLMVHKPIWCQNHRsvRTAFAVCGCVWVVAFVMCIPVFVY 160
Cdd:cd15204   83 TVSLYVSTNALLVIAIDRYLVIVHPLKPRMKR--RTACVVIALVWVVSLLLAIPSAVY 138
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
29-165 3.75e-09

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 57.29  E-value: 3.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGlpgNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLC-CLSLPFSVAHLILrGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd17790    9 ILSLVTVTG---NLLVLISFKVNSElKTVNNYFLLSLACADLIIgAFSMNLYTTYILM-GHWALGTVACDLWLALDYVAS 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLV 165
Cdd:cd17790   85 NASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLV 143
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
28-172 4.06e-09

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 57.21  E-value: 4.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLILrGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15325    5 VILGGFILFGVLGNILViLSVACHRHLQTVTHYFIVNLAVADLLlTSTVLPFSAIFEIL-GYWAFGRVFCNIWAAVDVLC 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCI-PVFVYRDLLVVDDySVC 172
Cdd:cd15325   84 CTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIgPLFGWKEPAPEDE-TIC 150
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
31-156 4.45e-09

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 57.44  E-value: 4.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  31 SLTCLLGLPGNG-LVLWVAGVKMKRTVNTVWFLHLTLADFLCCL-SLPFSVAHLILrGHWPYGLFLCKLIPSVIILNMFA 108
Cdd:cd15397    8 SLVMAVGLLGNIcLICVIARQKEKTNVTNILIANLSFSDILVCLvCLPFTVVYTLM-DYWIFGEVLCKMTPFIQCMSVTV 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564348849 109 SVFLLTAISLDR-CLMVHKPIWcqnHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15397   87 SILSLVLIALERhQLIINPTGW---KPSVSQAYLAVVVIWMLACFISLP 132
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
24-154 4.50e-09

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 57.59  E-value: 4.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGlpgNGLVLW-VAGVKMKRTVNTVWFLHLTLADFLC-CLSLPFSVAHLILRGhWPYGLFLCKLIPSV 101
Cdd:cd15980    4 IASYLLIFLLCMMG---NGVVCFiVLRSKHMRTVTNLFILNLAISDLLVgIFCMPTTLLDNIIAG-WPFGSTVCKMSGMV 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIwcQNHRSVRTAFAVCGCVWVVAF-VMC 154
Cdd:cd15980   80 QGISVSASVFTLVAIAVDRFRCIVYPF--KQKLTISTAVVIIVIIWVLAIaIMC 131
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
36-154 6.76e-09

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 56.94  E-value: 6.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  36 LGLPGNGLVL--WVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLL 113
Cdd:cd15169   13 LGFPLNVLAIrgATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFAPLYAGGGFL 92
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564348849 114 TAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWvvAFVMC 154
Cdd:cd15169   93 AALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIW--ALVLC 131
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
24-158 1.01e-08

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 56.49  E-value: 1.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVagVKMKRTVNTVWF---LHLTLADFLC-CLSLPFSVahLILRGhWPYGLFLCKLIP 99
Cdd:cd14968    1 AVYIVLEVLIAVLSVLGNVLVIWA--VKLNRALRTVTNyfiVSLAVADILVgALAIPLAI--LISLG-LPTNFHGCLFMA 75
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 100 SVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVM-CIPVF 158
Cdd:cd14968   76 CLVLVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVgLTPMF 135
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
35-159 1.08e-08

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 56.34  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLL 113
Cdd:cd15928   12 LVGASGNLLTVLVIGRSRDmRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCTYASILHI 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 564348849 114 TAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15928   92 TALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALV 137
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
27-160 1.54e-08

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 55.72  E-value: 1.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLP---GNGLVLWVAGV-KMKRTVNTVWFLHLTLADFLC-CLSLPFSVAHLILrGHWPYGLFLCKLIPSV 101
Cdd:cd15299    4 VLIAFLTGILALVtiiGNILVIVSFKVnKQLKTVNNYFLLSLACADLIIgVISMNLFTTYIIM-NRWALGNLACDLWLSI 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY 160
Cdd:cd15299   83 DYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILF 141
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
29-153 1.64e-08

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 55.82  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLAD-FLCCLSLPFSVAHLILrGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15065    5 FLSLIIVLAIFGNVLVcLAIFTDRRLRKKSNLFIVSLAVADlLVALLVMTFAVVNDLL-GYWLFGETFCNIWISFDVMCS 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVM 153
Cdd:cd15065   84 TASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALI 130
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-163 1.79e-08

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 55.59  E-value: 1.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLwVAGVKMKRTVNTVWFL--HLTLADFLCCL--SLPFSVAHLILRGHWPYglFLCKLIPSVIIL 104
Cdd:cd15387    6 VLALILFLALTGNICVL-LAIHTTRHKHSRMYFFmkHLSIADLVVAVfqVLPQLIWDITFRFYGPD--FLCRLVKYLQVV 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVcgcVWVVAFVMCIP---VFVYRDL 163
Cdd:cd15387   83 GMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVYVLF---SWLLSLVFSIPqvhIFSLREV 141
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-172 1.92e-08

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 55.32  E-value: 1.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  40 GNGLVLWVA-GVKMKRTVNTVWFLHLTLADflCCLSLPFSVAHLI--LRGHWPYGLFLCKLIPSVIILNMFASVFLLTAI 116
Cdd:cd16003   17 GNLIVIWIIlAHKRMRTVTNYFLVNLAFSD--ASMAAFNTLINFIyaLHSEWYFGEAYCRFHNFFPITSVFASIYSMTAI 94
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 117 SLDRCLMVHKPIwcQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd16003   95 AVDRYMAIIDPL--KPRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTLC 148
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
31-156 2.07e-08

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 55.26  E-value: 2.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  31 SLTCLLGLPGNGLVLWVAgVKMKRTVN--TVWFLHLTLADFLCCLSLPFSVAHlILRGHWPYGLFLCKLIPSVIILNMFA 108
Cdd:cd15183    8 SLVFIIGVVGNVLVVLVL-IQHKRLRNmtSIYLFNLAISDLVFLFTLPFWIDY-KLKDDWIFGDAMCKFLSGFYYLGLYS 85
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564348849 109 SVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15183   86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMP 133
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
31-185 2.08e-08

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 55.14  E-value: 2.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  31 SLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPF---SVAHlilrgHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15184    8 SLVFIFGFVGNMLVvLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFwahYAAN-----EWVFGNAMCKLLTGLYHIGF 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFDSSRaYDYW 185
Cdd:cd15184   83 FSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGSHYTCSPHFPPSQ-YQFW 160
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
27-165 2.99e-08

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 54.59  E-value: 2.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVLwvAGVKMKR---TVNTVWFLHLTLADF---LCCLSLpFSVahLILRGHWPYGLFLCKLIPS 100
Cdd:cd15297    4 VLVAGSLSLVTIIGNILVM--VSIKVNRhlqTVNNYFLFSLACADLiigVFSMNL-YTL--YTVIGYWPLGPVVCDLWLA 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 101 VIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLV 165
Cdd:cd15297   79 LDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV 143
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-184 4.92e-08

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 54.10  E-value: 4.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVA-GVKMKRTVNTVWFLHLTLAD-----FLCCLSLPFSVahlilRGHWPYGLFLCKLIPSV 101
Cdd:cd16002    5 VAYSVIVVVSVVGNIIVMWIIlAHKRMRTVTNYFLVNLAFAEasmsaFNTVINFTYAI-----HNEWYYGLEYCKFHNFF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIwcQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFDSSRA 181
Cdd:cd16002   80 PIAAVFASIYSMTAIALDRYMAIIHPL--QPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPEHEE 157

                 ...
gi 564348849 182 YDY 184
Cdd:cd16002  158 RKY 160
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
32-156 6.03e-08

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 54.00  E-value: 6.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  32 LTCLLGLPGNGLVLW--VAGVKMKRTVNtVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFAS 109
Cdd:cd15167    9 LIFLIGFIGSCFALWafIQKRSSRKCIN-IYLINLLTADFLLTLALPVKIAVDLGIAPWKLKIFHCQVTACLIYINMYLS 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564348849 110 VFLLTAISLDRCLMVHKPiwCQNHRSVRTAFA--VCGCVWVVAFVMCIP 156
Cdd:cd15167   88 IIFLGFVSIDRYLQLTHS--SKLYRIQEPGFAkmISAVVWTLVLFIMVP 134
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
329-433 6.21e-08

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 54.06  E-value: 6.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 329 LVVGFLVPFFIMITCYSLIV---FRMRKTN-LTKSRNKTLRVAVAVVTVFFVCWIPYHI-VGILLVITDQESALREVVLP 403
Cdd:cd14989  160 VTLGFIIPFSIIGLCYSLIVrvlVRAQKHRrLRPRRQKALRMILVVVLVFFICWLPENVfISIQLLQGTQEPSESYDESF 239
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 564348849 404 W------DHMSIALASANSCFNPFLYALLGKDFRKK 433
Cdd:cd14989  240 RhnhpltGHIVNLAAFSNSCLNPLIYSFLGETFRDK 275
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
31-188 6.41e-08

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 54.39  E-value: 6.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  31 SLTCLL--GLPGNGLVLWVagVKMKRTVNTVWF---LHLTLADFLCCLS-LPFSVAHLILRGHWPYGLFLCKLIPSVIIL 104
Cdd:cd15005    6 TLGLILcvSLAGNLLFSVL--IVRDRSLHRAPYyflLDLCLADGLRSLAcFPFVMASVRHGSGWIYGALSCKVIAFLAVL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCI-PVFVYRDLLVVDDYSVCGYNFDSSRAYD 183
Cdd:cd15005   84 FCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFpPVFDVGTYTFIREEDQCTFEHRSYKAND 163

                 ....*
gi 564348849 184 YWDYM 188
Cdd:cd15005  164 TLGFM 168
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
28-156 6.97e-08

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 53.63  E-value: 6.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAgVKMKRTVNTVWFLHLTL-ADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15151    5 VLYTVLFLVGLILNSVAAWIF-FHIPSTSTFIVYLKNTLvADLIMTLMLPFKILSDSGLGPWQLRAFVCRFSAVVFYITM 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15151   84 YISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVP 133
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
29-160 7.35e-08

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 53.68  E-value: 7.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVAgVKMKR--TVNTVWFLHLTLADFLCCLSLPFSVaHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15185    6 LYSLVFIVGLLGNVVVVVIL-IKYRRlrIMTNIYLLNLAISDLLFLFTLPFWI-HYVRWNNWVFGHGMCKLLSGFYYLGL 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY 160
Cdd:cd15185   84 YSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIF 137
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
322-432 7.87e-08

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 53.85  E-value: 7.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 322 VAITISRLVVGFLVPFFIMITCYSLIVFRMRK-----------------------TNLTKSRNKTLRVAVAVVTVFFVCW 378
Cdd:cd15382  165 LAYNIFNMITMYALPLIIIVFCYSLILCEISRkskekkedvseksssvrlrrssvGLLERARSRTLKMTIVIVLVFIICW 244
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 379 IPYHIVGILLVItDQESALRevVLPWDHMSI-ALASANSCFNPFLYALLGKDFRK 432
Cdd:cd15382  245 TPYFIMSLWYWF-DRESASK--VDPRIQKGLfLFAVSNSCMNPIVYGYFSIDLRR 296
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
28-156 8.92e-08

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 53.66  E-value: 8.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAgVKMKRTVNTVWFL-HLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15150    5 LLYTVLFIVGLTMNGLAMRVF-FQIPSKSNFIIFLkNTVISDLLMILTFPFKILSDAKLGSWPLRGFVCQVTSVIFYFTM 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15150   84 YISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLP 133
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
54-156 9.54e-08

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 53.09  E-value: 9.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  54 RTVNTVWFLHLTLADFLCCL-SLPFSVAHLILrGHWPYGLFLCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPIWCQN 132
Cdd:cd15049   32 RTVNNYFLLSLACADLIIGLvSMNLYTVYLVM-GYWPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPLTYRA 110
                         90       100
                 ....*....|....*....|....
gi 564348849 133 HRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15049  111 KRTPKRAILMIALAWVISFVLWAP 134
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
28-152 1.01e-07

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 53.15  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLwVAGVKMKR---TVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIIL 104
Cdd:cd15104    4 VILAVLSPLIITGNLLVI-VALLKLIRkkdTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVIT 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFV 152
Cdd:cd15104   83 SCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGL 130
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
28-156 1.11e-07

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 53.31  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMF 107
Cdd:cd15149    5 VFYSLVFIVGILLNGVNFWIFFYVPSNKSFIVYLKNIVFADLLMSLTFPFKILSDVELGPWQLNVIVCRYSAVIFYLNMY 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564348849 108 ASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15149   85 VGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVP 133
7tmA_MrgprE cd15112
mas-related G protein-coupled receptor subtype E, member of the class A family of ...
27-153 1.26e-07

mas-related G protein-coupled receptor subtype E, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320240  Cd Length: 272  Bit Score: 52.91  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLL---GLPGNGLVLWVAGVKMKRTVNTVWFLHLTLAD--FLCClslpfsvaHLI------LRGHWPYGLFLC 95
Cdd:cd15112    1 LFILSLTELLglgGLLGNGLVLWLLSSNVYRNPFSIYLLDVACADliFLCC--------HMVaiipelLQNHLSFPHFVY 72
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849  96 KLIPSVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVM 153
Cdd:cd15112   73 DSLLALRFFCYIVGLSLLAAISAEQCLATLFPAWYQCRRPRHLTTCVCALLWALCLLL 130
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
24-156 1.55e-07

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 52.52  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGV-KMKRTVNTVWFLHLTLADF-LCCLSLPFSVAHLILrGHWPYGLFLCKLIPSV 101
Cdd:cd15301    1 VLIVIVAAVLSLVTVGGNVMVMISFKIdKQLQTISNYFLFSLAVADFaIGVISMPLFTVYTAL-GYWPLGYEVCDTWLAI 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15301   80 DYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPP 134
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
29-164 1.58e-07

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 52.46  E-value: 1.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLwVAGVKMKRTVNTVWFL--HLTLADFLCCL-SLPFSVAHLILrGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15398    6 LYTFISLLGFLGNLLIL-TALTKKWKQKTIINFLigNLAFSDILVVLfCSPFTLTCVLL-DQWIFGEVMCHIVPFLQCVS 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIwcQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLL 164
Cdd:cd15398   84 VMVSTLMLMSIAIVRYHMIKHPL--SNHLTANHGYFLLGTVWTLGFTICSPLPVFHKIV 140
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
28-157 1.68e-07

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 52.43  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLW-VAGVKMKRTVNTVWFLHLTLADFLC-CLSLPFSVAHLiLRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15050    5 IALSTISLITVILNLLVLYaVRTERKLHTVGNLYIVSLSVADLIVgAVVMPLNIVYL-LESKWILGRPVCLFWLSMDYVA 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPV 157
Cdd:cd15050   84 STASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPI 135
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
27-164 1.69e-07

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 52.57  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCL-SLPFSVAHLILRgHWPYGLFLCKLIPSVIIL 104
Cdd:cd15978    4 ILLYSLIFLLSVLGNSLIIAVlIRNKRMRTVTNIFLLSLAVSDLMLCLfCMPFTLIPNLLK-DFIFGSAVCKTATYFMGI 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLL 164
Cdd:cd15978   83 SVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLV 142
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
28-182 1.73e-07

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 52.60  E-value: 1.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLC-CLSLPFSvAHLILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15958    5 LLMALIVLLIVAGNVLVIVAIGRTQRlQTLTNLFITSLACADLVMgLLVVPFG-ATLVVRGRWLYGSFFCELWTSVDVLC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVV-AFVMCIPVFVY-------RDLLVVDDYSVCgyNFD 177
Cdd:cd15958   84 VTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAIsALVSFLPIMMHwwrdeddQALKCYEDPGCC--DFV 161

                 ....*
gi 564348849 178 SSRAY 182
Cdd:cd15958  162 TNRAY 166
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
28-173 1.78e-07

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 52.20  E-value: 1.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCCLS-LPFSVAHLILrGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15326    5 LVLGAFILFAIVGNILViLSVVCNRHLRIPTNYFIVNLAIADLLLSFTvLPFSATLEIL-GYWVFGRIFCDIWAAVDVLC 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCI-PVFVYRDLLVVDDYsVCG 173
Cdd:cd15326   84 CTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIgPLLGWKEPAPPDDK-VCE 151
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
28-161 2.11e-07

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 52.20  E-value: 2.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLlglpGNGLVL-WVAGVKMKRTVNTVWFLHLTLADFLCCLSLpFSVA--HLILRGHwpYGLF--------LCK 96
Cdd:cd15137    9 VVGIIALL----GNLFVLiWRLKYKEENKVHSFLIKNLAIADFLMGVYL-LIIAsvDLYYRGV--YIKHdeewrsswLCT 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849  97 LIPSVIILNMFASVFLLTAISLDRCLMVHKPIwcQNHR-SVRTAFAVCGCVWVVAFVMC-IPVFVYR 161
Cdd:cd15137   82 FAGFLATLSSEVSVLILTLITLDRFICIVFPF--SGRRlGLRRAIIVLACIWLIGLLLAvLPLLPWD 146
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
28-173 2.13e-07

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 52.22  E-value: 2.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCCLS-LPFSvAHLILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15327    5 VFLAIFILMAIVGNILViLSVACNRHLQTVTNYFIVNLAIADLLLSTTvLPFS-ATLEVLGFWAFGRVFCDIWAAVDVLC 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCI-PVFVYRDLLVVDDySVCG 173
Cdd:cd15327   84 CTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIgPLLGWKEPPPPDE-SICS 151
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
27-158 2.35e-07

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 52.19  E-value: 2.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGlpgNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGhWPYGLFLCKLIPSVIILN 105
Cdd:cd15079    7 YIFLGIVSLLG---NGLVIYIfSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEG-WALGPLGCQIYAFLGSLS 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIwcQNHRSVRT-AFAVCGCVWVVAFVMCIPVF 158
Cdd:cd15079   83 GIGSIWTNAAIAYDRYNVIVKPL--NGNPLTRGkALLLILFIWLYALPWALLPL 134
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
24-432 2.93e-07

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 52.09  E-value: 2.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCL-SLPFSVAHLILRgHWPYGLFLCKLIPSV 101
Cdd:cd15205    1 TAFVITYVLIFVLALFGNSLVIYVvTRKRAMRTATNIFICSLALSDLLITFfCIPFTLLQNISS-NWLGGAFMCKMVPFV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVddysvcgynfdssra 181
Cdd:cd15205   80 QSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLEVK--------------- 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 182 ydyWDYMYNSHLpeinppdnstghvddrtapssVPARDLWTattalqsqtfhtspedpfsqdSASQQPHYggkpptvlia 261
Cdd:cd15205  145 ---YDFLYEKRH---------------------VCCLERWY---------------------SPTQQKIY---------- 169
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 262 tipggfpvedhksntlntgaflsahtepsltasssplyahdfpddyfdqlmygnhawtpqvaiTISRLVVGFLVPFFIMI 341
Cdd:cd15205  170 ---------------------------------------------------------------TTFILVILFLLPLTTML 186
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 342 TCYSLIVFRM--RK----------------TNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLp 403
Cdd:cd15205  187 FLYSRIGYELwiKKrvgdasvlqtihgiemSKISRKKKRAVKMMVTVVLLFAVCWAPFHVVHMMIEYSNLENKYDGVTI- 265
                        410       420       430
                 ....*....|....*....|....*....|...
gi 564348849 404 wdHMSIALASA----NSCFNPFLYALLGKDFRK 432
Cdd:cd15205  266 --KLIFAIVQLigfsNSFNNPIVYAFMNENFKK 296
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
29-179 2.96e-07

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 52.11  E-value: 2.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCC-LSLPFSVAHLIlRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15056    6 FLSLVILLTILGNLLViVAVCTDRQLRKKTNYFVVSLAVADLLVAvLVMPFGAIELV-NNRWIYGETFCLVRTSLDVLLT 84
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFDSS 179
Cdd:cd15056   85 TASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIPTFISFLPIMQGWNHIGIEDLIAFNCASGST 157
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
325-432 3.13e-07

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 51.68  E-value: 3.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 325 TISRLVVGFLVPFFIMITCYSLIVFRMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVgiLLVITDQESALREVVLPW 404
Cdd:cd15184  165 TLKMNILGLVLPLLVMIICYSGILKTLLRCRNEKKRHKAVRLIFTIMIVYFLFWAPYNIV--LLLNTFQEFFGLNNCSSS 242
                         90       100       110
                 ....*....|....*....|....*....|....
gi 564348849 405 DHMSIA------LASANSCFNPFLYALLGKDFRK 432
Cdd:cd15184  243 NRLDQAmqvtetLGMTHCCINPVIYAFVGEKFRS 276
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
24-168 4.36e-07

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 51.49  E-value: 4.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTclLGLPGN-GLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVI 102
Cdd:cd15125    3 IPSLYLLIIT--VGLLGNiTLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQ 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 103 ILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDD 168
Cdd:cd15125   81 LTSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMP 146
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
24-159 4.66e-07

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 51.18  E-value: 4.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVI 102
Cdd:cd15300    1 ITIAAVTAVVSLITIVGNVLVMISFKVNSQlKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALD 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 103 ILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15300   81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPIL 137
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
26-162 4.98e-07

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 51.09  E-value: 4.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  26 SMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFL-HLTLADFLC-CLSLPFSVAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15304    3 PALLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLmSLAIADMLLgFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDV 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWV--VAFVMCIPVFVYRD 162
Cdd:cd15304   83 LFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTisVGISMPIPVFGLQD 143
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
40-157 5.27e-07

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 50.99  E-value: 5.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  40 GNGLVLWVAGVKMKRTVNTVWFL-HLTLADFLCCL-SLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLLTAIS 117
Cdd:cd15306   17 GNILVILAVSLEKKLQYATNYFLmSLAVADLLVGLfVMPIALLTILFEAMWPLPLVLCPIWLFLDVLFSTASIMHLCAIS 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 564348849 118 LDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPV 157
Cdd:cd15306   97 LDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPV 136
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
28-159 5.86e-07

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 50.94  E-value: 5.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGV-KMKRTVNTVWFLHLTLADFLC-CLSLPFSVAHlILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15296    5 VLMALLVVATVLGNALVILAFVVdSSLRTQGNFFFLNLAISDFLVgGFCIPLYIPY-VLTGRWKFGRGLCKLWLVVDYLL 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSV-RTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15296   84 CTASVFNIVLISYDRFLSVTRAVSYRAQKGMtRQAVLKMVLVWVLAFLLYGPAII 138
7tmA_MAS1L cd15113
mas-related G protein-coupled receptor 1-like (MAS1L), member of the class A family of ...
32-151 6.25e-07

mas-related G protein-coupled receptor 1-like (MAS1L), member of the class A family of seven-transmembrane G protein-coupled receptors; MAS1L is also called MAS1 oncogene-like (MAS1-like) or mas-related G-protein coupled receptor MRG. MAS1L is a G protein-coupled receptor that only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L. The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320241  Cd Length: 265  Bit Score: 50.60  E-value: 6.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  32 LTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLAD--FLCCLSLPFSVAHLILrgHWPYGLFLCKLIPSVIILNMFAS 109
Cdd:cd15113    9 LVSLCGLVGNGVVFWLLCCGVRSNPYMVYILNLAAADviNLSCSAVILLEVTLLL--YHGVTLFVADFLEPVSYFSDTVG 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 564348849 110 VFLLTAISLDRCLMVHKPIWCqNHRSVRTAFAVCGCVWVVAF 151
Cdd:cd15113   87 LCLLVAISTESCLCVLFPIWC-CHRPKYTSAVVSTLSWGLPL 127
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
28-161 6.31e-07

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 50.89  E-value: 6.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWvAGVKMKRTVNTVWFLHLTLA--DFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd14964    3 IILSLLTCLGLLGNLLVLL-SLVRLRKRPRSTRLLLASLAacDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGA 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYR 161
Cdd:cd14964   82 NLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGK 137
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
301-423 8.38e-07

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 50.51  E-value: 8.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 301 HDFPDDYFDQLMYGNH--AWTPQVAITISrLVVGFLVPFFIMITCYSLIVFRMRKTN--------------------LTK 358
Cdd:cd15384  142 GPFVEDFHQCVTYGFYtaEWQEQLYNMLS-LVFMFPIPLVIMVTCYVLIFITLSKSSrdfqgleiytrnrgpnrqrlFHK 220
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 359 SRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITdQESALREVVLPWDHMsiaLASANSCFNPFLY 423
Cdd:cd15384  221 AKVKSLRMSAVIVTAFILCWTPYYVIMIWFLFF-NPYPLNDILFDVIFF---FGMSNSCVNPLIY 281
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
333-432 8.50e-07

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 50.44  E-value: 8.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 333 FLVPFFIMITCYSLIVF----RMRKT---------------NLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVItdQ 393
Cdd:cd15383  176 FLLPLLIMIFCYTRILLeisrRMKEKkdsaknevalrsssdNIPKARMRTLKMTIVIVSSFIVCWTPYYLLGLWYWF--S 253
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 564348849 394 ESALREVVLPW-DHMSIALASANSCFNPFLYALLGKDFRK 432
Cdd:cd15383  254 PEMLEQTVPESlSHILFLFGLLNACLDPLIYGLFTISFRR 293
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
19-161 9.99e-07

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 50.31  E-value: 9.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  19 FKPQDIASMV-ILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCC-LSLPFSVAHLILrGHWPYGLFLC 95
Cdd:cd15321    1 YSVQATAAIAaAITFLILFTIFGNVLViIAVLTSRSLRAPQNLFLVSLAAADILVAtLIIPFSLANELM-GYWYFRKTWC 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849  96 KLIPSVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYR 161
Cdd:cd15321   80 EIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYK 145
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
24-156 1.27e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 49.59  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVlwVAGVKMKRTVNTV---WFLHLTLADFLC-CLSLPFSVAHLILrGHWPYGLFLCKLIP 99
Cdd:cd15330    1 IITSLFLGTLILCAIFGNACV--VAAIALERSLQNVanyLIGSLAVTDLMVsVLVLPMAALYQVL-NKWTLGQVTCDLFI 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 100 SVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15330   78 ALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIP 134
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
35-175 1.41e-06

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 49.90  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWVAGVKMKRTVNTVWFL-HLTLADFLC-CLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFL 112
Cdd:cd15305   12 ILTIGGNILVIMAVSLEKKLQNATNFFLmSLAVADMLVgILVMPVSLIAILYDYAWPLPRYLCPIWISLDVLFSTASIMH 91
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 113 LTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAF--VMCIPVFVYRDLLVVDDYSVCGYN 175
Cdd:cd15305   92 LCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIgiSMPIPVIGLQDDEKVFVNGTCVLN 156
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
304-432 1.53e-06

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 49.73  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 304 PDDYFDQLMYGNHAWTpqvaitisRLVVGFLVPFFIMITCYSLIVFRMRKTNLT---------KSRNKTLRVAVAVVTVF 374
Cdd:cd14977  159 PSTPFAETYPKARSWW--------LFGCYFCLPLAFTAVCYLLMARTLIRAAKEytrgtkkhmKQRRQLAKTVLCLVLVF 230
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 375 FVCWIPYHIVGILLVITDQESA--LREVVLPWDHMSIALASANSCFNPFLYALLGKDFRK 432
Cdd:cd14977  231 AFCWLPEHISNILRATLYNEVLidTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRR 290
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
35-165 2.11e-06

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 49.25  E-value: 2.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLL 113
Cdd:cd15298   12 LVTVVGNILVMLSIKVNRQlQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNL 91
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564348849 114 TAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLV 165
Cdd:cd15298   92 LIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVV 143
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
29-178 2.16e-06

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 49.16  E-value: 2.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLILrGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15323    6 VVGFLIVFTIVGNVLVvIAVLTSRALRAPQNLFLVSLASADILvATLVMPFSLANELM-GYWYFGQVWCNIYLALDVLFC 84
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDD-YSVCGYNFDS 178
Cdd:cd15323   85 TSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEGDvYPQCKLNDET 157
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
29-185 2.59e-06

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 49.05  E-value: 2.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLwVAGVKMKRTVNTVWFL--HLTLADFLCCL--SLPFSVAHLILRGHWPYglFLCKLIPSVIIL 104
Cdd:cd15385    6 VLAVIFAVAVIGNSSVL-LALYKTKKKASRMHLFikHLSLADLVVAFfqVLPQLCWDITYRFYGPD--FLCRIVKHLQVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQnHRSVRTAFAVCGCVWVVAFVMCIP---VFVYRDLLVVDDYSVCGYNFDS--- 178
Cdd:cd15385   83 GMFASTYMLVMMTADRYIAICHPLKTL-QQPTKRSYLMIGSAWALSFILSTPqyfIFSLSEIENGSGVYDCWANFIVpwg 161

                 ....*..
gi 564348849 179 SRAYDYW 185
Cdd:cd15385  162 IKAYITW 168
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
28-159 2.88e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 48.89  E-value: 2.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLL----GLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLC-CLSLPFSVAHLILRGHWPYGLFLCKLIPSV 101
Cdd:cd14979    1 VLVTAIYVAifvvGIVGNLLTCIViARHKSLRTTTNYYLFSLAVSDLLIlLVGLPVELYNFWWQYPWAFGDGGCKLYYFL 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd14979   81 FEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILF 138
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
28-159 3.10e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 48.81  E-value: 3.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAgVKMKRTVNTVWFLHLTLA--DFLCCLSL-PFSVAHlILRGHWPYGLFLCKLIPSVIIL 104
Cdd:cd15074    5 IYLTVIGILSTLGNGTVLFVL-YRRRSKLKPAELLTVNLAvsDLGISVFGyPLAIIS-AFAHRWLFGDIGCVFYGFCGFL 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWcQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15074   83 FGCCSINTLTAISIYRYLKICHPPY-GPKLSRRHVCIVIVAIWLYALFWAVAPLV 136
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
28-150 3.27e-06

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 48.71  E-value: 3.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLwVAGVKMKR--TVNTVWFLHLTLADFLCCLSL-PFSVAHLILRgHWPYGLFLCKLIPSVIIL 104
Cdd:cd15957    5 IVMSLIVLAIVFGNVLVI-TAIAKFERlqTVTNYFITSLACADLVMGLAVvPFGAAHILLK-TWTFGNFWCEFWTSIDVL 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVA 150
Cdd:cd15957   83 CVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVS 128
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
24-151 3.34e-06

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 48.67  E-value: 3.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLAD-FLCCLSLPFSVAHLILrGHWPYGLFLCKLIPSV 101
Cdd:cd15391    1 PHLINLYQSTIFLSVGGNYSVIVVfYDGRRSRTDLNYYLINLAVSDlIMALFCMPFTFTQIML-GHWVFPAPMCPIVLYV 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIwcQNHRSVRTAFAVCGCVWVVAF 151
Cdd:cd15391   80 QLVSVTASVLTNTAIGIDRFFAVIFPL--RSRHTKSRTKCIIASIWAISF 127
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
35-163 3.37e-06

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 48.66  E-value: 3.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGN-GLVLWVAGVKMKRTVNTVWFLHLTLADFLCCL-SLPFSVAHlILRGHWPYGLFLCKLIPSVIILNMFASVFL 112
Cdd:cd15395   12 ILGVSGNlALIIIILKQKEMHNVTNILIVNLSFSDLLMTImCLPFTFVY-TLMDHWVFGEAMCKLNSMVQCISITVSIFS 90
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564348849 113 LTAISLDR-CLMVHKPIWCQNHRSVRTAFAVcgcVWVVAFVMCIPVFVYRDL 163
Cdd:cd15395   91 LVLIAIERhQLIINPRGWRPNNRHAYVGIAV---IWVLAVLTSLPFLIFQVL 139
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
27-161 3.92e-06

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 48.65  E-value: 3.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVL-WV-AGVKMKRTVNTVwFLHLTLADFL-CCLSLPFSVAHLILRGHWPYGLFLCKLIPSVII 103
Cdd:cd15198    4 LIFLGVILVAGVAGNTTVLcWLcGGRRRKSRMNFL-LLQLALADLLvIGGTALSQIIWELLGDRWMAGDVACRLLKLLQA 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPiwcqnHRSVRTAFAVCGCVWVVAFVMCIP-VFVYR 161
Cdd:cd15198   83 SARGASANLVVLLALDRHQAIRAP-----LGQPLRAWKLAALGWLLALLLALPqAYVFR 136
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
31-172 4.71e-06

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 48.30  E-value: 4.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  31 SLTCLLGLPGNGLVLWV--AGVKMkRTVNTVWFLHLTLADFlcCLSLPFSVAHLILRGH--WPYGLFLCKLIPSVIILNM 106
Cdd:cd16004    8 SLIVLVAVTGNATVIWIilAHRRM-RTVTNYFIVNLALADL--SMAAFNTAFNFVYASHndWYFGLEFCRFQNFFPITAM 84
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIwcQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd16004   85 FVSIYSMTAIAADRYMAIIHPF--KPRLSAGSTKVVIAGIWLVALALAFPQCFYSTVTMDQGRTKC 148
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
24-186 5.67e-06

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 47.80  E-value: 5.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLW-VAGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLILRGhWPYGLFLCKLIPSV 101
Cdd:cd14977    1 YVIMSLSLVIFAVGIIGNLMVLCiVCTNYYMRSVPNILIASLALGDLLlLLLCVPLNAYNLLTKD-WLFGDVMCKLVPFI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDY-----SVCGYNF 176
Cdd:cd14977   80 QVTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVARESSLdnsslTVCIMKP 159
                        170
                 ....*....|
gi 564348849 177 DSSRAYDYWD 186
Cdd:cd14977  160 STPFAETYPK 169
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
333-431 5.75e-06

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 47.74  E-value: 5.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 333 FLVPFFIMITCYSLIVFRMRKTN----LTKSRNKTLrvavavvtvfFVCWIPYHIVGILLVITDQESalrevVLPWDHMS 408
Cdd:cd15072  169 FILPLFILLTSYSSIEQKLKKEGhlrfNTGLPLLTL----------LICWGPYAILALYAAITDVTS-----ISPKLRMV 233
                         90       100
                 ....*....|....*....|....
gi 564348849 409 IALASANSC-FNPFLYALLGKDFR 431
Cdd:cd15072  234 PALLAKTSPtINAILYALGNENYR 257
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
25-156 5.78e-06

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 47.84  E-value: 5.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  25 ASMVILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCC-LSLPFSVAHLILRGHWPYGLFLCklIPSVI 102
Cdd:cd15212    2 AQALVLLAIFLLSSLGNCAVIGVIVKHRQlRTVTNAFILSLSLSDLLTAlLCLPFAFLTLFSRPGWLFGDRLC--LANGF 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 103 ILNMFA--SVFLLTAISLDR-CLMVHKPiwcQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15212   80 FNACFGivSTLTMTLISFDRyYAIVRQP---QGKIGRRRALQLLAAAWLTALGFSLP 133
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
29-188 6.15e-06

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 47.87  E-value: 6.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVAG-VKMKRTVNTVWFLHLTLADFLCCL--SLPFSVAHLILRGHWPYglFLCKLIPSVIILN 105
Cdd:cd15386    6 VLAAILVVATAGNLAVLLAMYrMRRKMSRMHLFVLHLALTDLVVALfqVLPQLIWEITYRFQGPD--LLCRAVKYLQVLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQnHRSVRTAFAVCGCVWVVAFVMCIP---VFVYRDLL----VVDDYSVCGYNFdS 178
Cdd:cd15386   84 MFASTYMLIMMTVDRYIAVCHPLRTL-QQPSRQAYLMIGATWLLSCILSLPqvfIFSLREVDqgsgVLDCWADFGFPW-G 161
                        170
                 ....*....|
gi 564348849 179 SRAYDYWDYM 188
Cdd:cd15386  162 AKAYITWTTL 171
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
30-159 6.70e-06

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 47.96  E-value: 6.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  30 LSLTCLL----GLPGNGL-VLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIIL 104
Cdd:cd15131    3 ITVTCVLlfvvGVTGNLMtMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSES 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15131   83 CTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFV 137
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
24-157 7.07e-06

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 47.48  E-value: 7.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGhwpyGLFLCKLIPSV- 101
Cdd:cd15163    1 LALMVINTLIFLVGIVLNSLALYVFCFRTKtKTTSVIYTINLVVTDLLVGLSLPTRIVMYYSAG----NCLTCSFVHIFs 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPV 157
Cdd:cd15163   77 YFVNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSI 132
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
27-160 7.81e-06

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 47.50  E-value: 7.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVLWVAGV-KMKRTVNTVWFLHLTLADFL---CCLslPFSvahLI--LRGHWPYGLFLCKLIPS 100
Cdd:cd15979    4 ILLYSVIFLLSVFGNMLIIVVLGLnKRLRTVTNSFLLSLALSDLMlavFCM--PFT---LIpnLMGTFIFGEVICKAVAY 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 101 VIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY 160
Cdd:cd15979   79 LMGVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVY 138
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
29-158 8.74e-06

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 47.37  E-value: 8.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCCL-SLPFSvAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15066    5 AMTLIILAAIFGNLLViISVMRHRKLRVITNYFVVSLAMADMLVALcAMTFN-ASVEITGRWMFGYFMCDVWNSLDVYFS 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVV-AFVMCIPVF 158
Cdd:cd15066   84 TASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISpALISFLPIF 136
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
34-161 8.95e-06

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 47.36  E-value: 8.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  34 CLLGLPGNGLVLWVAGVKMKRTVNTV--WFLHLTLADFL-CCLSLPFSVAHLILRGhWPYGLFLCKLIPSVIILNMFASV 110
Cdd:cd15383   11 FVLSACSNLAVLWSATRNRRRKLSHVriLILHLAAADLLvTFVVMPLDAAWNVTVQ-WYAGDLACRLLMFLKLFAMYSSA 89
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 111 FLLTAISLDRCLMVHKPI-----WCQNHRSVRTAfavcgcvWVVAFVMCIP-VFVYR 161
Cdd:cd15383   90 FVTVVISLDRHAAILNPLaigsaRRRNRIMLCAA-------WGLSALLALPqLFLFH 139
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
24-157 9.78e-06

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 47.14  E-value: 9.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLILRGHWPYGLFLCKLIPSV 101
Cdd:cd15308    1 AAALVGGVLLILAIIAGNVLVcLSVCTERALKTTTNYFIVSLAVADLLlALLVLPLYVYSEFQGGVWTLSPVLCDALMTM 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPI-WCQNHRSVRTAFAVcGCVWVVAFVMCIPV 157
Cdd:cd15308   81 DVMLCTASIFNLCAISVDRFIAVSVPLnYNRRQGSVRQLLLI-SATWILSFAVASPV 136
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
40-172 1.08e-05

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 46.89  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  40 GNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCC-LSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLLTAIS 117
Cdd:cd15310   17 GNVLVcMAVLRERALQTTTNYLVVSLAVADLLVAtLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAIS 96
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849 118 LDRCLMVHKPIWCQ---NHRSVRTAFAVCGCVWVVAFVMCIPVFVyrDLLVVDDYSVC 172
Cdd:cd15310   97 IDRYTAVVMPVHYQhgtGQSSCRRVSLMITAVWVLAFAVSCPLLF--GFNTTGDPTVC 152
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
25-185 1.37e-05

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 46.69  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  25 ASMVILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCL--SLPFSVAHLILRGHWPYglFLCKLIPSV 101
Cdd:cd15388    2 VEIAVLAIIFACALLSNSLVLLVlWRRRKQLARMHVFMLHLCIADLVVAFfqVLPQLVWDITDRFRGPD--VLCRLVKYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCgCVWVVAFVMCIP-VFVYRDLLVVDDYSVCGYNFDSS- 179
Cdd:cd15388   80 QVVGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVC-VAWAISLILSLPqVFIFSKVEVAPGVYECWACFIEPw 158

                 ....*...
gi 564348849 180 --RAYDYW 185
Cdd:cd15388  159 glKAYVTW 166
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
36-191 1.63e-05

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 46.46  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  36 LGLPGNGLVLWV--AGVKMKRTVNTVWFLHLTLADFLCCLSLPF-SVAHLILRGHwpYGLF--------LCKLIPSVIIL 104
Cdd:cd14980   13 LALIGNILVIIWhiSSKKKKKKVPKLLIINLAIADFLMGIYLLIiAIADQYYRGR--YAQYseewlrspPCLLACFLVSL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIwcQNHR-SVRTAFAVCGCVWVVAFVMC-IPVFvyrdllvvddysvcgynFDSSRAY 182
Cdd:cd14980   91 SSLMSVLMMLLITLDRYICIVYPF--SNKRlSYKSAKIILILGWLFSIIFAaIPIL-----------------YSINQPG 151

                 ....*....
gi 564348849 183 DYWDYMYNS 191
Cdd:cd14980  152 DNRLYGYSS 160
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
30-159 1.74e-05

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 46.09  E-value: 1.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  30 LSLTCLLGLP------GNGLVL-WVAGVKMKRTVNTVWFLHLTLADFLCC-LSLPFSVAHLILrGHWPYGLFLCKLIPSV 101
Cdd:cd15322    1 LTLIILVGLLmlltvfGNVLVIiAVFTSRALKAPQNLFLVSLASADILVAtLVIPFSLANEVM-GYWYFGKVWCEIYLAL 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15322   80 DVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI 137
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
326-434 1.77e-05

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 46.46  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 326 ISRLVVGFLVpFFIMITCYSLIVFRMRKTNLTKSRNKTLRVAVAVVTVFF------VCWIPYHIVGILLVITDQEsaLRE 399
Cdd:cd14980  177 IAYLLLTFIA-WIIICILYILIFISVRKSRKSARRSSSKRDKRIAIRLALilitdlICWLPYYIVIFSGLLTSTE--IDI 253
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 564348849 400 VVLPWdhmsIALAS--ANSCFNPFLYALLGKDFRKKA 434
Cdd:cd14980  254 HVLQF----IAILAlpLNSAINPYLYTLTTPTFKRDF 286
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
35-151 1.82e-05

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 46.27  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLwVAGVKMK--RTVNTVWFLHLTLADF-LCCLSLPFSVAhLILRGHWPYGLFLCKLIPSVIILNMFASVF 111
Cdd:cd15073   12 IISTISNGIVL-VTFVKFRelRTPTNALIINLAVTDLgVSIIGYPFSAA-SDLHGSWKFGYAGCQWYAFLNIFFGMASIG 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564348849 112 LLTAISLDRCLMVHKP-IWCQnhRSVRTAFAVCGCVWVVAF 151
Cdd:cd15073   90 LLTVVAVDRYLTICRPdLGRK--MTTNTYTVMILLAWTNAF 128
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
28-149 2.28e-05

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 46.29  E-value: 2.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLW-VAGVKMKRTVNTVWFLHLTLADFLCCLS-LPFSVAHLIlRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15317    5 IVLVLAMLITVSGNLVVIIsISHFKQLHSPTNMLVLSLATADFLLGLCvMPFSMIRTV-ETCWYFGDLFCKFHTGLDLLL 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVV 149
Cdd:cd15317   84 CTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLV 127
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
64-160 2.95e-05

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 45.78  E-value: 2.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  64 LTLADFLCCLS-LPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAV 142
Cdd:cd15134   42 LAVSDLLLLILgLPFELYTIWQQYPWVFGEVFCKLRAFLSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRI 121
                         90
                 ....*....|....*...
gi 564348849 143 CGCVWVVAFVMCIPVFVY 160
Cdd:cd15134  122 IIAIWIIAFVCALPFAIQ 139
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-158 3.64e-05

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 45.56  E-value: 3.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGL-VLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15132    5 IVCLILFVVGVTGNTMtVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYRLWKSRPWIFGEFLCRLYHYISEGCT 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564348849 107 FASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVF 158
Cdd:cd15132   85 YATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFL 136
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
21-159 5.42e-05

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 45.11  E-value: 5.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  21 PQDIASMVILSLTCLlglpGNGLVLWVAGVKMKRTVNTVWF-LHLTLADFlcCLSLPFSVAHLILR--GHWPYGLFLCKL 97
Cdd:cd15197    2 EQLATLWVLFVFIVV----GNSSVLFALWMRKAKKSRMNFFiTQLAIADL--CVGLINVLTDIIWRitVEWRAGDFACKV 75
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564348849  98 IPSVIILNMFASVFLLTAISLDRCLMVHKPIwcQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15197   76 IRYLQVVVTYASTYVLVALSIDRYDAICHPM--NFSQSGRQARVLICVAWILSALFSIPMLI 135
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
24-162 5.44e-05

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 44.65  E-value: 5.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVlwVAGVKMKRTVNTV---WFLHLTLADFL-CCLSLPFSVAHLIlRGHWPYGLFLCKLIP 99
Cdd:cd15331    1 VLTSIILGLLILATIIGNVFV--IAAILLERSLQGVsnyLILSLAVADLMvAVLVMPLSAVYEV-SQHWFLGPEVCDMWI 77
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564348849 100 SVIILNMFASVFLLTAISLDRCLMVHKPIWCQNhRSVRTAFAVCGCVWVVAFVMCI-PVFVYRD 162
Cdd:cd15331   78 SMDVLCCTASILHLVAIALDRYWAVTNIDYIRR-RTAKRILIMIAVVWFVSLIISIaPLFGWKD 140
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
313-432 5.75e-05

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 44.96  E-value: 5.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 313 YGNHAWTPQVAITISRLVVGFLVPFFIMITCYSLIVFRMRK------------TNLTKSRNKTLRVAVAVVTVFFVCWIP 380
Cdd:cd15074  155 TGASASVGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSsrkrvagfdsrsKRQHKIERKVTKVAVLICAGFLIAWTP 234
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564348849 381 YHIVGILLVITDQESALREV-VLPwdhmsIALASANSCFNPFLYALLGKDFRK 432
Cdd:cd15074  235 YAVVSMWSAFGSPDSVPILAsILP-----ALFAKSSCMYNPIIYLLFSSKFRQ 282
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
27-163 6.63e-05

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 44.82  E-value: 6.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGN-GLVLWVAGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHlILRGHWPYGLFLCKLIPSVIIL 104
Cdd:cd15396    4 IIAYSVVTIVGLFGNlCLITIIKKQKEEHNVTNILIANLSLSDVLvCVMCIPFTAVY-TLMDHWIFGETMCKLTSFVQSV 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 105 NMFASVFLLTAISLDRC-LMVHKPIWcqnHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDL 163
Cdd:cd15396   83 SVSVSIFSLVLIAIERYqLIVNPRGW---KPSASHAYWGIVLIWLFSLMISIPFLIFHQL 139
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
321-432 7.08e-05

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 44.23  E-value: 7.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 321 QVAITISRLVVGFLVPFFIMITCYSLIvFRMrktnlTKSRNKTLRVAVAVVTVFFVCWIPYHIvgILLVITDQESALREV 400
Cdd:cd15049  160 DPAITFGTAIAAFYLPVLVMTILYWRI-YRE-----TARERKAARTLSAILLAFIITWTPYNI--LVLVSTFCAKCIPDT 231
                         90       100       110
                 ....*....|....*....|....*....|..
gi 564348849 401 VlpWDhMSIALASANSCFNPFLYALLGKDFRK 432
Cdd:cd15049  232 L--WS-FGYWLCYINSTINPFCYALCNKTFRK 260
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
325-433 7.17e-05

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 44.46  E-value: 7.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 325 TISRLVVGFLVPFFIMITCYSLI---VFRMR-------KTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQE 394
Cdd:cd15400  161 TIAVVVIHFIVPITVVSFCYLRIwvlVIQVRrkvksesKPRLKPSDFRNFLTMFVVFVIFAICWAPLNLIGLAVAINPQE 240
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 564348849 395 SALRevVLPWDH-MSIALASANSCFNPFLYALLGKDFRKK 433
Cdd:cd15400  241 MAPK--VPEWLFvVSYFMAYFNSCLNAIIYGLLNQNFRKE 278
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
27-156 7.72e-05

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 44.09  E-value: 7.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLILrGHWPYGLFLCKLIPSVIIL 104
Cdd:cd15324    4 VLVVVVIILVTIVGNVLVvVAVFTSRALRAPQNLFLVSLASADILvATLVIPFSLANEVM-GYWYFGSTWCAFYLALDVL 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15324   83 FCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFP 134
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
35-158 7.96e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 44.62  E-value: 7.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLIL-RGHWPYGLFLCKLIPSVIILNMFASVFL 112
Cdd:cd15337   12 ILGVIGNLLVIYLfSKTKSLRTPSNMFIINLAISDFGFSAVNGFPLKTISSfNKKWIWGKVACELYGFAGGIFGFMSITT 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 564348849 113 LTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVF 158
Cdd:cd15337   92 LAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPF 137
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
333-431 9.12e-05

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 44.46  E-value: 9.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 333 FLVPFFIMITCYSLIVFRM-RKTN--------LTKSRNKTLRVAVAVVTVFFVCWIPYHIVGIL-LVITDQESALR---- 398
Cdd:cd15976  181 FCLPLACTAVFYTLMTCEMlRKKNgmqialndHLKQRREVAKTVFCLVLVFALCWLPLHLSRILkLTIYDEKDPNRcell 260
                         90       100       110
                 ....*....|....*....|....*....|...
gi 564348849 399 EVVLPWDHMSIALASANSCFNPFLYALLGKDFR 431
Cdd:cd15976  261 SFFLVLDYIGINMASLNSCINPIALYLVSKRFK 293
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
34-172 1.01e-04

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 44.13  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  34 CLLGLPGNGLVL-WVAGVKMKRTVNTVWFLHLTLADFLCCLSLPF-SVAHLILRGH-------WPYGLfLCKLIPSVIIL 104
Cdd:cd15136   11 FLLALVGNIIVLlVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLlAIVDAKTLGEyynyaidWQTGA-GCKTAGFLAVF 89
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVM-CIPvfvyrdLLVVDDY---SVC 172
Cdd:cd15136   90 SSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMaLLP------LVGVSSYsktSIC 155
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
29-161 1.06e-04

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 44.01  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLIlRGHWPYGLFLCKLIPSVIILNMFA 108
Cdd:cd14994    7 LYSVVLIGGVIGVILMSFLLVKMNTRSVTTTAVINLIVVHSLFLLTVPFRIYYYA-SKTWKFGMPLCKMVSAMIHIHMHL 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 109 SVFLLTAISLDRCLMVHKpiWCQNHRSVRT--AFAVCGCVWVVAFVMCIPVFVYR 161
Cdd:cd14994   86 TFLFYVIILVIRYLIFFQ--RKDKMEFYRKlhAVAASAVVWVLVLLIVVPVFVKE 138
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
27-162 1.13e-04

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 43.66  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVLWVAGV-KMKRTVNTVWFLHLTLADFLC-CLSLPFSVAHlILRGHWPYGLFLCKLIPSVIIL 104
Cdd:cd15295    4 LFLMSLLALVIVLGNALVIIAFVVdKNLRHRSNYFFLNLAISDFFVgAISIPLYIPY-TLTNRWDFGRGLCVFWLVIDYL 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQN-HRSVRTAFAVCGCVWVVAFVMCIPVFVYRD 162
Cdd:cd15295   83 LCTASVYNIVLISYDRYQSVSNAVSYRNqQTATLRIVTQMVAVWVLAFLVHGPAILVSD 141
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
24-177 1.20e-04

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 43.63  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVlwVAGVKMKRTVNT-VWFLHLTLA--DFLCC-LSLPFSVAHLIlRGHWPYGLFLCKLIP 99
Cdd:cd15333    5 ISLAVLLALITLATTLSNAFV--IATIYLTRKLHTpANYLIASLAvtDLLVSiLVMPISIVYTV-TGTWTLGQVVCDIWL 81
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849 100 SVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVCGYNFD 177
Cdd:cd15333   82 SSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVNTD 159
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
24-156 1.21e-04

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 44.04  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGlpgNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLC-CLSLPFSVAHLILRGhWPYGLFLCKLIPSV 101
Cdd:cd15981    4 ILAYLFIFLLCMVG---NGLVcFIVLKNRQMRTVTNMFILNLAVSDLLVgIFCMPTTLVDNLITG-WPFDNAMCKMSGLV 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIwcQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15981   80 QGMSVSASVFTLVAIAVERFRCIVHPF--RQKLTLRKAIVTIVIIWVLALIIMCP 132
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
32-157 1.22e-04

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 43.79  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  32 LTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCC-LSLPFSVAHLILrGHWPYGLFLCKLIPSVIILNMFAS 109
Cdd:cd15307    9 VLVLGTAAGNILVcLAIAWERRLQNVTNYFLMSLAITDLMVAvLVMPLGILTLVK-GHFPLSSEHCLTWICLDVLFCTAS 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564348849 110 VFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPV 157
Cdd:cd15307   88 IMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPL 135
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
28-159 1.63e-04

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 43.55  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLlGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCL--SLPFSVAHLILRghWPYGLFLCKLIPSVIIL 104
Cdd:cd15336    6 VILIIGIT-GMLGNALVIYAfCRSKKLRTPANYFIINLAVSDFLMSLtqSPIFFVNSLHKR--WIFGEKGCELYAFCGAL 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFV 159
Cdd:cd15336   83 FGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLF 137
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
333-433 2.08e-04

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 43.30  E-value: 2.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 333 FLVPFFIMITCYSLIVFRMRKTNLTKSRN------KTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESAL----REVVL 402
Cdd:cd15149  173 FWVVFLLLIIFYVAISRKIYKSNQKFRRNstnmkaKSSRNIFSILFVFFVCFVPYHALRIPYTLSQTGADYscqsKTILY 252
                         90       100       110
                 ....*....|....*....|....*....|.
gi 564348849 403 PWDHMSIALASANSCFNPFLYALLGKDFRKK 433
Cdd:cd15149  253 YMKEFTLLLSAANVCLDPIIYFFLCQPFREM 283
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
329-432 2.90e-04

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 42.54  E-value: 2.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 329 LVVGFLVPFFIMITCYSLIVF-------------------RMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLV 389
Cdd:cd15055  168 LVLTFILPCTVMIVLYMRIFVvarsqarairshtaqvsleGSSKKVSKKSERKAAKTLGIVVGVFLLCWLPYYIVSLVDP 247
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 564348849 390 ITDQESALREVVLpWdhmsiaLASANSCFNPFLYALLGKDFRK 432
Cdd:cd15055  248 YISTPSSVFDVLI-W------LGYFNSCLNPLIYALFYPWFRK 283
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
25-156 2.93e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 43.01  E-value: 2.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  25 ASMVILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLILRGHWPYGLFLCKLIPSVI 102
Cdd:cd15217    2 VKLVLLGLIICVSLAGNLIVsLLVLKDRALHKAPYYFLLDLCLADTIrSAVCFPFVLVSIRNGSAWTYSVLSCKIVAFMA 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 103 ILNMFASVFLLTAISLDRCLMV-HKPIWCQnHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15217   82 VLFCFHAAFMLFCISVTRYMAIaHHRFYSK-RMTFWTCIAVICMVWTLSVAMAFP 135
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
317-433 3.43e-04

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 42.46  E-value: 3.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 317 AWTPQVAITISRLVVGFLVPFFIMITCYSLI----------VFRMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGI 386
Cdd:cd15209  153 AQTVSTVYTITVVVIHFLLPLLIVSFCYLRIwvlvlqvrqrVKPDQRPKLKPADVRNFLTMFVVFVLFAVCWAPLNFIGL 232
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564348849 387 LLVITDQESALRevVLPWDHM-SIALASANSCFNPFLYALLGKDFRKK 433
Cdd:cd15209  233 AVAINPKEMAPK--IPEWLFVaSYFMAYFNSCLNAIIYGLLNQNFRKE 278
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-167 3.76e-04

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 42.53  E-value: 3.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVA-GVKMKRTVNTVWFLHLTLADFL-CCLSLPFSVAHLiLRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15976    5 VVSCLVFVLGIIGNSTLLRIIyKNKCMRNGPNILIASLALGDLLhIIIDIPINVYKL-LAEDWPFGVEMCKLVPFIQKAS 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 106 MFASVFLLTAISLDRCLMVH-----KPIWCQNHRSVRTAFavcgcVWVVAFVMCIPVFVYRDLLVVD 167
Cdd:cd15976   84 VGITVLSLCALSIDRYRAVAswsriKGIGVPKWTAVEIVL-----IWVVSIILAVPEAIGFDMITMD 145
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
324-432 3.78e-04

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 42.12  E-value: 3.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 324 ITISRLVVGFLVPFFIMITCYslivFRMRKTNLTKSRNKTL-RVAVAVVTVFFVCWIPYHIVGILLVITDQESaLREVVL 402
Cdd:cd15171  168 LTLKMNIVVLVFPLLVFIICC----VQLRKTQRFRERQRDLsKLVFAIMVVFLLMWAPYNIALFLSAFKEHFS-LRDCKS 242
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564348849 403 PWD-----HMSIALASANSCFNPFLYALLGKDFRK 432
Cdd:cd15171  243 SYHldasvQVTKLIATTHCCVNPLLYALLDPAFRR 277
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
64-162 3.99e-04

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 42.22  E-value: 3.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  64 LTLADFLCC-LSLPFSVAHLILRgHWPYGLFLCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAV 142
Cdd:cd15335   42 LAVTDFLVAvLVMPLSITYIVMD-TWTLGYFICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLM 120
                         90       100
                 ....*....|....*....|
gi 564348849 143 CGCVWVVAFVMCIPVFVYRD 162
Cdd:cd15335  121 ILTVWTISIFISIPPLFWRN 140
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
330-432 4.43e-04

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 42.12  E-value: 4.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 330 VVGFLVPFFIMITCYSLIVfrmrKTNL---TKSRNKTLRVAVAVVTVFFVCWIPYHIV-------GILLVITDQESALRE 399
Cdd:cd15185  171 IFGLALPLLIMVICYTGII----KTLLrcpSKKKYKAIRLIFVIMVVFFIFWTPYNLVlllsafqSIFFETDCERSKHLD 246
                         90       100       110
                 ....*....|....*....|....*....|...
gi 564348849 400 VVLpwdHMSIALASANSCFNPFLYALLGKDFRK 432
Cdd:cd15185  247 LAM---QVTEVIAYTHCCINPVIYAFVGERFRK 276
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
35-160 4.77e-04

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 42.12  E-value: 4.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWVAgVKMK--RTVNTVWFLHLTLADFLCCLSLPFSvAHLILRGHWPyGLFLCKLIPSVIILNMFASVF- 111
Cdd:cd15171   12 LVGLLDNGLVVFIL-VKYKglKHVENIYFLNLAVSNLCFLLTLPFW-AHAAWHGGSL-GNPTCKVLVALSSVGLHSEALf 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564348849 112 --LLTAISLDRCLmvHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY 160
Cdd:cd15171   89 nvLLTVQASRVFF--HGRLASSARRVAPCGIIASVLAWLTAFLVTLPEFVF 137
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
30-157 5.43e-04

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 41.91  E-value: 5.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  30 LSLTCLLGLPGNGLVlwVAGV----KMKRTVNTVWFLHLTLADFLCC-LSLPFSVAHLIlRGHWPYGLFlCKLIPSVIIL 104
Cdd:cd15320    8 LSVLILSTLLGNTLV--CAAVirfrHLRSKVTNFFVISLAVSDLLVAvLVMPWKAVAEI-AGFWPFGSF-CNIWVAFDIM 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMC-IPV 157
Cdd:cd15320   84 CSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISfIPV 137
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
325-431 5.66e-04

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 41.50  E-value: 5.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 325 TISRLVVGFLVPFFIMITCYSLIvFRMrktnlTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREV---V 401
Cdd:cd15330  160 TIYSTFGAFYIPLILMLVLYGRI-FKA-----AARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESTCHMPELlgaI 233
                         90       100       110
                 ....*....|....*....|....*....|
gi 564348849 402 LPWdhmsiaLASANSCFNPFLYALLGKDFR 431
Cdd:cd15330  234 INW------LGYSNSLLNPIIYAYFNKDFQ 257
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
24-157 6.09e-04

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 41.87  E-value: 6.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  24 IASMVILSLTCLLGLPGNGLVLW--VAGVKMKRTVNTVWFLHLTLAD-FLCCLSLPF-SVAHLIlrGHWPYGLFlCKLIP 99
Cdd:cd15319    1 VVTGCLLSLLILWTLLGNILVCAavVRFRHLRSKVTNIFIVSLAVSDlFVALLVMPWkAVAEVA--GYWPFGAF-CDVWV 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 100 SVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMC-IPV 157
Cdd:cd15319   78 AFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISfIPV 136
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
28-162 6.29e-04

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 41.77  E-value: 6.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLP----GNGLVLW-VAGVKMKRTVNTVWFLHLTLADFLCCLS-LPFSVAHLIlRGHWPYGLFLCKLIPSV 101
Cdd:cd15318    1 LVIYLACAIGMLiivlGNLFVVVtVSHFKALHTPTNFLLLSLALADMLLGLTvLPFSTIRSV-ESCWYFGDSFCRLHTCL 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCiPVFVYRD 162
Cdd:cd15318   80 DTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYT-SVFLYTK 139
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
32-172 6.52e-04

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 41.35  E-value: 6.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  32 LTCL-------LGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRgHWPYGLfLCKLIPSVII 103
Cdd:cd14989    2 LSCLytiflfpIGFIGNILILVVnLSFREKMTIPDLYFVNLAVADLILVADSLIEVFNLNEK-YYDIAV-LCTFMSLFLQ 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564348849 104 LNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd14989   80 INMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATLLPFTAVQAQHTGEVHFC 148
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
64-161 7.74e-04

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 41.09  E-value: 7.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  64 LTLADFLCC-LSLPFSVAHlILRGHWPYGLFLCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAV 142
Cdd:cd15334   42 LAVTDFLVAvLVMPFSIMY-IVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIM 120
                         90
                 ....*....|....*....
gi 564348849 143 CGCVWVVAFVMCIPVFVYR 161
Cdd:cd15334  121 IAVVWIISIFISMPPLFWR 139
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
317-433 8.43e-04

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 41.05  E-value: 8.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 317 AWTPQVAITISRLVVGFLVPFFIMITCYSLIVF-------RMRKTNLTKSRNKTLR---VAVAVVTVFFVCWIPYHIVGI 386
Cdd:cd15401  153 AQTVSSSYTITVVVVHFIVPLSIVTFCYLRIWVlviqvkhRVRQDSKQKLKANDIRnflTMFVVFVLFAVCWGPLNFIGL 232
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 564348849 387 LLVITDQESALRevVLPWDH-MSIALASANSCFNPFLYALLGKDFRKK 433
Cdd:cd15401  233 AVAINPLKVAPK--IPEWLFvLSYFMAYFNSCLNAVIYGVLNQNFRKE 278
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
35-156 8.68e-04

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 41.36  E-value: 8.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCCL-SLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFL 112
Cdd:cd15133   12 VVGVVGNVLTcLVIARHKAMRTPTNYYLFSLAVSDLLVLLlGMPLELYELWQNYPFLLGSGGCYFKTFLFETVCLASILN 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564348849 113 LTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15133   92 VTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALP 135
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
27-153 9.18e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 41.08  E-value: 9.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGLPGNGLVLWVAGVKMK-RTVNTVWFLHLTLADFLC-CLSLPFSVAhliLRGHWPYGLFLCKLIPSVIIL 104
Cdd:cd15068    4 ITVELAIAVLAILGNVLVCWAVWLNSNlQNVTNYFVVSLAAADIAVgVLAIPFAIT---ISTGFCAACHGCLFIACFVLV 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564348849 105 NMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVM 153
Cdd:cd15068   81 LTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAI 129
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
323-433 9.95e-04

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 41.04  E-value: 9.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 323 AITISRLVVGFLVPFFIMITCYS---LIVFRMR-------KTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGiLLVITD 392
Cdd:cd15402  159 AYTIAVVFFHFILPIIIVTFCYLriwILVIQVRrrvkpdnKPKLKPHDFRNFVTMFVVFVLFAVCWAPLNFIG-LAVAVD 237
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564348849 393 QESALREVVLPWDHMSIALASANSCFNPFLYALLGKDFRKK 433
Cdd:cd15402  238 PETIVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRRE 278
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
321-431 1.02e-03

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 41.19  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 321 QVAITISrlvvgFLVPFFIMITCYSLIVFRMRK-TNLTKSRNKTLRVAVAVVTVFFV-----------------CWIPYH 382
Cdd:cd14979  173 QVSTFIF-----FVLPMFVISILYFRIGVKLRSmRNIKKGTRAQGTRNVELSLSQQArrqvvkmlgavviaffvCWLPFH 247
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 564348849 383 IVGIL-LVITDQESALREVVLPWDHMSIALASANSCFNPFLYALLGKDFR 431
Cdd:cd14979  248 AQRLMfSYASKEDTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFR 297
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
332-432 1.08e-03

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 40.77  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 332 GFLVPFFIMITCYSLIVFRMRK--------------------TNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVIt 391
Cdd:cd15337  174 GFLCPLLIIIFCYVNIIRAVRNhekemtqtaksgmgkdteknDARKKAEIRIAKVAIILISLFLLSWTPYAVVALLGQF- 252
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 564348849 392 dqesALREVVLPW-DHMSIALASANSCFNPFLYALLGKDFRK 432
Cdd:cd15337  253 ----GPAYWITPYvSELPVMFAKASAIYNPIIYALSHPKFRA 290
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
330-432 1.10e-03

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 41.01  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 330 VVGFLVPFFIMITCYSLIV-FRMRKTNLTKSrnKTLRVAVAVVTVFFVCWIPYHIVGILLVITD---QESALREVVLPWD 405
Cdd:cd15183  171 LLGLILPLLVMIICYTGIInILLRRPNEKKA--KAVRLIFVITLLFFLLWTPYNLAAFVSAFQDvlfTPSCEQSQQLDLA 248
                         90       100
                 ....*....|....*....|....*...
gi 564348849 406 HM-SIALASANSCFNPFLYALLGKDFRK 432
Cdd:cd15183  249 LQvTEVIAYTHCCVNPVIYVFVGERFRK 276
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
25-163 1.16e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 40.99  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  25 ASMVILSLTCLLGLPGNGLVLWvaGVKMKRTVNTVWF---LHLTLADfLCCLSLPFSVAHLILRGHWPYgLFLCKLIPSV 101
Cdd:cd15071    2 AYIGIEVLIALVSVPGNVLVIW--AVKVNQALRDATFcfiVSLAVAD-VAVGALVIPLAIIINIGPQTE-FYSCLMVACP 77
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564348849 102 IILNMFASVFLLTAISLDRCLMVHKPIwcqNHRSV----RTAFAVCGCvWVVAFVM-CIPVFVYRDL 163
Cdd:cd15071   78 VLILTQSSILALLAIAVDRYLRVKIPT---RYKSVvtprRAAVAIAGC-WILSFLVgLTPMFGWNNL 140
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
334-432 1.16e-03

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 40.70  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 334 LVPFFIMITCYSLIvFRMRKTNLTKSRN---------------KTLRVAVAVVTVFFVCWIPYHIVG-ILLVITDQEsal 397
Cdd:cd14968  175 LVPLLIMLVIYLRI-FRVIRKQLRQIESllrsrrsrstlqkevKAAKSLAIILFLFALCWLPLHIINcITLFCPECK--- 250
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564348849 398 reVVLPWDHMSIALASANSCFNPFLYALLGKDFRK 432
Cdd:cd14968  251 --VPKILTYIAILLSHANSAVNPIVYAYRIRKFRQ 283
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
318-432 1.46e-03

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 40.49  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 318 WTPQVAITISRLVVGF----LVPFFIMITCYSLIVFRMR---KTNLTKSR---NKTLRVAVAVVTVFFVCWIPYHIVGIL 387
Cdd:cd15086  154 WTSRSANSISYIICLFifclLLPFLVMVYCYGRLLYAIKqvgKINKSTARkreQHVLLMVVTMVICYLLCWLPYGVMALL 233
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564348849 388 L------VITDQESALREVvlpwdhmsiaLASANSCFNPFLYALLGKDFRK 432
Cdd:cd15086  234 AtfgkpgLVTPVASIVPSI----------LAKSSTVVNPIIYVFMNKQFYR 274
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
60-188 2.13e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 40.02  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  60 WFLHLTLADFL-CCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRT 138
Cdd:cd15218   38 FLLDLCCSDILrSAICFPFVFTSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWT 117
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564348849 139 AFAVCGCVWVVAFVMCI-PVFVYRDLLVVDDYSVCGYNFDSSRAYDYWDYM 188
Cdd:cd15218  118 CLAVICMVWTLSVAMAFpPVLDVGTYSFIREEDQCTFQHRSFRANDSLGFM 168
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
333-432 2.14e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 40.01  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 333 FLVPFFIMITCYSLIVFRMRKTNL--------------TKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLV-ITDQESAL 397
Cdd:cd15134  182 FIIPMIAIIVLYVLIGLQLRRSTLlrrgqrsvsggrrsSQSRRTVLRMLVAVVVAFFICWAPFHAQRLLTVyAKNMTPPY 261
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 564348849 398 REVVLPWDHMSIALASANSCFNPFLYALLGKDFRK 432
Cdd:cd15134  262 LFINRILFYISGVLYYVSSTVNPILYNVMSAKYRQ 296
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
28-160 2.34e-03

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 39.73  E-value: 2.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLVLWVAGV-KMKRTVNTVWFLHLTLADFLCCL-SLPFSVAHLILRGHWPYGLFLCKLIPSVIILN 105
Cdd:cd15302    5 LITAILSIITVIGNILVLLSFYVdRNIRQPSNYFIASLAVSDLLIGLeSMPFYTVYVLNGDYWPLGWVLCDLWLSVDYTV 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 106 MFASVFLLTAISLDRCLMVHKPiwcQNHRSVRTAFAVcgcVWVVAFVMCIPVFVY 160
Cdd:cd15302   85 CLVSIYTVLLITIDRYCSVKIP---AKYRNWRTPRKV---LLIIAITWIIPALLF 133
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
330-432 2.96e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 39.33  E-value: 2.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 330 VVGFLVPFFIMITCYSLIVFRMRKtnltksRNKTLRVAVAVVTVFFVCWIPYHIvgILLVITDQESALREVVlpwdHM-S 408
Cdd:cd15050  170 ILNFYIPSLLMLWFYAKIFKAVNR------ERKAAKQLGFIMAAFILCWIPYFI--LFMVIAFCKNCCNENL----HMfT 237
                         90       100
                 ....*....|....*....|....
gi 564348849 409 IALASANSCFNPFLYALLGKDFRK 432
Cdd:cd15050  238 IWLGYINSTLNPFIYPLCNENFKK 261
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
333-432 3.39e-03

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 39.34  E-value: 3.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 333 FLVPFFIMITCYSLIVFRMRKtnltksRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVV--LPWdhmsia 410
Cdd:cd15060  169 FFIPLLIMTIVYVKIFIATSK------ERRAARTLGIIMGVFVVCWLPFFLMYVILPFCETCSPSAKVVnfITW------ 236
                         90       100
                 ....*....|....*....|..
gi 564348849 411 LASANSCFNPFLYALLGKDFRK 432
Cdd:cd15060  237 LGYVNSALNPVIYTIFNLDFRR 258
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
331-432 3.86e-03

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 38.96  E-value: 3.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 331 VGFLV-PFF--IMITCY---SLIVFRMRKTNLTKSRN---KTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVV 401
Cdd:cd15302  157 VQFMTdPYFnmGMYIGYywtTLIVMLILYAGIYRAANrarKALRTITFILGAFVICWTPYHILATIYGFCEAPPCVNETL 236
                         90       100       110
                 ....*....|....*....|....*....|.
gi 564348849 402 LpwdHMSIALASANSCFNPFLYALLGKDFRK 432
Cdd:cd15302  237 Y---TISYYLCYMNSPINPFCYALANQQFKK 264
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
310-431 4.02e-03

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 38.89  E-value: 4.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 310 QLMYGNHAWTPQVAITISRLVVGFLVPFFIMITCYSLIVFRMRKTnltKSRNKTlrVAVAVVTVFFVCWIPYHIVGILLV 389
Cdd:cd15213  147 QCVLGYTESPADRIYVVLLLVAVFFIPFLIMLYSYFCILNTVRSF---KTRAFT--TILILFIGFSVCWLPYTVYSLLSV 221
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564348849 390 ITD--QESALREVVLPWdhmsiaLASANSCFNPFLYALLGKDFR 431
Cdd:cd15213  222 FSRysSSFYVISTCLLW------LSYLKSAFNPVIYCWRIKKFR 259
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
29-161 4.71e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 38.95  E-value: 4.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLVLWV-AGVKMKRTVNTVWFLHLTLADFLCCLSLP-FSVAHLILRgHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15000    5 MFLPVVLFGIFGNFVLLYIlASNRSLRTPTNLLIGNMALADLLTLLVCPwMFLVHDFFQ-NYVLGSVGCKLEGFLEGSLL 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564348849 107 FASVFLLTAISLDRCLMVHKPiwCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVYR 161
Cdd:cd15000   84 LASVLALCAVSYDRLTAIVLP--SEARLTKRGAKIVIVITWIVGLLLALPLAIYR 136
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
27-158 4.74e-03

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 38.97  E-value: 4.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  27 MVILSLTCLLGlpgNGLVLwVAGVKMKRTVNTVWFLHLTLADFLCCLSL-PFS-VAHLILRGHWPYGLFLCKLipsVIIL 104
Cdd:cd15220    6 MVLLDLTALVG---NTAVM-VVIAKTPHLRKFAFVCHLCVVDLLAALLLmPLGiLSSSPFFLGVVFGEAECRV---YIFL 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849 105 NMF---ASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCI-PVF 158
Cdd:cd15220   79 SVClvsASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLlPVL 136
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
29-158 4.90e-03

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 38.68  E-value: 4.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMF 107
Cdd:cd15400    6 VLIFTTVVDILGNLLViISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVI 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 564348849 108 ASVFLLTAISLDR-CLMVHKPIWCQNHRSVRTAFAVCgCVWVVAFVMCIPVF 158
Cdd:cd15400   86 GSIFNITGIAINRyCYICHSFAYDKLYSRWNTLLYVC-LIWALTVVAIVPNF 136
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
377-431 4.91e-03

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 39.04  E-value: 4.91e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 377 CWIPYHIVGIL-LVITDQESALR----EVVLPWDHMSIALASANSCFNPFLYALLGKDFR 431
Cdd:cd15128  238 CWLPLHLSRILkLTVYDQNDPNRcellSFLLVLDYFGINLATLNSCINPIALYFVSRKFK 297
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
337-431 5.02e-03

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 38.69  E-value: 5.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 337 FFIMITCYSLivfRMRKTNLT-------KSRNKTLRVAVAVVTVFFVCWIPYHIVGIL-----LVITDQESALREVVLPW 404
Cdd:cd15975  194 FYTLMTCEML---NRRKGSLRialsehlKQRREVAKTVFCLVVIFALCWFPLHLSRILkktvyNENDPRRCELLSFLLVM 270
                         90       100
                 ....*....|....*....|....*..
gi 564348849 405 DHMSIALASANSCFNPFLYALLGKDFR 431
Cdd:cd15975  271 DYISINLATMNSCINPIALYFVSKKFK 297
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
35-158 5.71e-03

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 38.65  E-value: 5.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  35 LLGLPGNGLVLWVA--GVKMKRTVNTVwFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFL 112
Cdd:cd15076   12 IVGTPLNAIVLFVTikYKKLRQPLNYI-LVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTGWS 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 564348849 113 LTAISLDRCLMVHKPIwcQNHR-SVRTAFAVCGCVWVVAFVMCIPVF 158
Cdd:cd15076   91 LAFLAFERYIVICKPF--GNFRfGSKHALGAVVATWIIGIGVSLPPF 135
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
54-167 5.98e-03

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 38.68  E-value: 5.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  54 RTVNTVWFLHLTLADFLCC-LSLPFSVAHLiLRGHWPYGLFLCKLIPSVIILNMFASVFLLTAISLDR------CLMVHK 126
Cdd:cd15127   32 RSISNSLLANLAFWDFLIIfFCLPLVIFHE-LTKKWLLGDFSCKIVPYIEVASLGVTTFTLCALCIDRfraatnVQMYYE 110
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 564348849 127 PIwcQNHRSVRTAFAVcgcVWVVAFVMCIPVFVYRDLLVVD 167
Cdd:cd15127  111 MI--ENCTSTTAKLAV---IWVGALLLALPEVVLRQLSKED 146
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
22-156 6.01e-03

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 38.38  E-value: 6.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  22 QDIASMVILSLTCLlglpGNgLVLWVAGVKMKR--TVNTVWFLHLTLADFL-CCLSLPFSVAHLILRgHWPYGLFLCKLI 98
Cdd:cd15214    2 ESIAIIIIAILICL----GN-LVIVVTLYKKSYllTLSNKFVFSLTLSNLLlSVLVLPFVVTSSIRR-EWIFGVVWCNFS 75
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564348849  99 PSVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIP 156
Cdd:cd15214   76 ALLYLLISSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLP 133
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
316-431 6.23e-03

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 38.65  E-value: 6.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 316 HAWTPQVAITISRLVVGFLVPFFIMITCYSLIVFRM------------RKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHI 383
Cdd:cd15391  158 GPDTSRSAYTVFVMLLTYIIPLLILTSTYGYVGFRLwnrtapgnadkgRDDMQIKSKRKVIKMLVFVVLMFGICWLPLHL 237
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564348849 384 VGILLVITD-----QESALREVVLpwdhMSIALASANSCFNPFLYALLGKDFR 431
Cdd:cd15391  238 FNLVQDFSTvfrnmPQHTTRLIYG----ACHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
41-158 6.35e-03

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 38.43  E-value: 6.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  41 NGLVLwvAGVKMKRTVNTVWFL---HLTLADFLCCLslpFSVAHLILRGHWPYGL--FLCKLIPSVIILNMFASVFLLTA 115
Cdd:cd14972   16 NSLVL--AAIIKNRRLHKPMYIliaNLAAADLLAGI---AFVFTFLSVLLVSLTPspATWLLRKGSLVLSLLASAYSLLA 90
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 564348849 116 ISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMC-IPVF 158
Cdd:cd14972   91 IAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAlLPVL 134
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
377-433 7.08e-03

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 38.20  E-value: 7.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564348849 377 CWIPYHIVGILLVITDQE----SALREVVLPWDHMSIALASANSCFNPFLYALLGKDFRKK 433
Cdd:cd15167  221 CFVPYHIVRIPYTLSQSEvitdCSLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFRSK 281
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
331-432 7.54e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 38.35  E-value: 7.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 331 VGFLVPFFIMITCYSLIVFRMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITdQESALREVVLPWDHMSIA 410
Cdd:cd15305  167 VAFFIPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLIMWCPFFITNILSVLC-KEACDQKLMEELLNVFVW 245
                         90       100
                 ....*....|....*....|..
gi 564348849 411 LASANSCFNPFLYALLGKDFRK 432
Cdd:cd15305  246 VGYVSSGINPLVYTLFNKTYRR 267
7tmA_PGD2 cd15140
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
26-154 8.28e-03

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor (also called prostanoid DP receptor, DP1, or PGD2R1) is a G-protein coupled receptor whose endogenous ligand is prostaglandin D2 (PGD2). PGD2, the major cyclooxygenase metabolite of arachidonic acid produced by mast cells, mediates inflammatory reactions in response to allergen challenge and causes peripheral vasodilation. PGD2 exerts its biological effects by binding to two types of cell surface receptors: a DP1 receptor that belongs to the prostanoid receptor family and a chemoattractant receptor-homologous molecule expressed on the T-helper type 2 cells (CRTH2 or PD2R2).


Pssm-ID: 320268 [Multi-domain]  Cd Length: 312  Bit Score: 38.34  E-value: 8.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  26 SMVILSLTCLLGLPGNGL---VLWVAGVKMK-----RTVNTVWFL---HLTLADFL--CCLSLPFSVAHL---ILRGHWP 89
Cdd:cd15140    3 SVVSSSLLFAAGLLGNLLalgLLWLHKLHAKkqrggRPRTSVFYVlvtVLTVTDLLgkCLLSPVVLAAYAqnrSLVGLTP 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564348849  90 YG-LFLCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMC 154
Cdd:cd15140   83 AGnLNLCQVFAFLMIFFGLASTFILLAMALECWLSLGHPFFYQRHINKRLGALVSLILYAFCLGFC 148
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
28-158 9.27e-03

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 37.71  E-value: 9.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  28 VILSLTCLLGLPGNGLV-LWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNM 106
Cdd:cd15309    5 MLLTLLIFVIVFGNVLVcMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMC 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564348849 107 FASVFLLTAISLDRCLMVHKP-IWCQNHRSVRTAFAVCGCVWVVAFVMCIPVF 158
Cdd:cd15309   85 TASILNLCAISIDRYTAVAMPmLYNTRYSSKRRVTVMISVVWVLSFAISCPLL 137
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
29-120 9.37e-03

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 37.72  E-value: 9.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  29 ILSLTCLLGLPGNGL-VLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRgHWPYGLFLCKLIPSVIILNMF 107
Cdd:cd15072    6 ILLVEALVGFSLNGLtILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASSSLLR-RWPYGSEGCQAHGFQGFFTAL 84
                         90
                 ....*....|...
gi 564348849 108 ASVFLLTAISLDR 120
Cdd:cd15072   85 ASICSSAAIAWDR 97
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
334-431 9.53e-03

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 37.99  E-value: 9.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 334 LVPFFIMITCYSLIVF----RMRKTNLTKSRNKTL-------RVAVAVVTVFFVCWIPYHIVGillVITDQESALREVVL 402
Cdd:cd15069  185 LPPLLIMLVIYIKIFLvacrQLQRTELMDHSRTTLqreihaaKSLAIIVGIFALCWLPVHILN---CITLFQPEFSKSKP 261
                         90       100       110
                 ....*....|....*....|....*....|
gi 564348849 403 PWD-HMSIALASANSCFNPFLYALLGKDFR 431
Cdd:cd15069  262 KWAmNVAILLSHANSVVNPIVYAYRNRDFR 291
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
62-172 9.68e-03

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 37.92  E-value: 9.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849  62 LHLTLADFLC-CLSLPFSVAHLIlRGHWPYGLFLCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPI-WCQNHRSVRTA 139
Cdd:cd15055   40 LSLAVADFLVgLLVMPFSMIRSI-ETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLlYPTKITIRRVK 118
                         90       100       110
                 ....*....|....*....|....*....|....
gi 564348849 140 FAVCGCvWVV-AFVMCIPVFVYRDLLVVDDYSVC 172
Cdd:cd15055  119 ICICLC-WFVsALYSSVLLYDNLNQPGLIRYNSC 151
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
333-423 9.86e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 37.88  E-value: 9.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348849 333 FLVPFFIMITCYSLIVFRMRK---------------------------TNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVG 385
Cdd:cd15385  174 FVVPVIILLTCYGFICYNIWRnikcktrrglsdnalknillavcvssvKTISRAKIRTVKMTFVIVLAYIVCWAPFFTIQ 253
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 564348849 386 ILLViTDQESALREVVLPWDHMSIALASANSCFNPFLY 423
Cdd:cd15385  254 MWSV-WDQNFPWDESENTAVTITALLASLNSCCNPWIY 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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