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Conserved domains on  [gi|564368942|ref|XP_006245231|]
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angio-associated migratory cell protein isoform X3 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10078108)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; similar to Homo sapiens angio-associated migratory cell protein that plays a role in angiogenesis and cell migration

Gene Ontology:  GO:0005515
PubMed:  10322433

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-381 1.78e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 192.94  E-value: 1.78e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942  81 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVET 160
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 161 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 237
Cdd:cd00200   83 GECVRTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLtTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 238 DLKQGNPIHVLkgtEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 317
Cdd:cd00200  163 DLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG------------------ 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564368942 318 LGFCSVMP---LAAVGYLDGTLAIYDLSTQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGVVRLWD 381
Cdd:cd00200  222 VNSVAFSPdgyLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 384-422 1.37e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.37e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 564368942   384 TGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 422
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-381 1.78e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 192.94  E-value: 1.78e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942  81 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVET 160
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 161 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 237
Cdd:cd00200   83 GECVRTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLtTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 238 DLKQGNPIHVLkgtEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 317
Cdd:cd00200  163 DLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG------------------ 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564368942 318 LGFCSVMP---LAAVGYLDGTLAIYDLSTQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGVVRLWD 381
Cdd:cd00200  222 VNSVAFSPdgyLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
81-421 1.34e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.17  E-value: 1.34e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942  81 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVET 160
Cdd:COG2319   73 TLLGHTAAVLSVAFSPDGRLLA-SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 161 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 237
Cdd:COG2319  152 GKLLRTLTghSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 238 DLKQGNPIHVLKGtegHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 317
Cdd:COG2319  232 DLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG------------------ 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 318 lgfcsVMPLA--------AVGYLDGTLAIYDLSTQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGVVRLWDARTGRLL 388
Cdd:COG2319  291 -----VNSVAfspdgkllASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365

                        330       340       350
                 ....*....|....*....|....*....|...
gi 564368942 389 TDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 421
Cdd:COG2319  366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 118-156 4.87e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.87e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 564368942   118 DGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 156
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
119-156 3.59e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 3.59e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 564368942  119 GELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 156
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 384-422 1.37e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.37e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 564368942   384 TGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 422
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-381 1.78e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 192.94  E-value: 1.78e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942  81 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVET 160
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 161 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 237
Cdd:cd00200   83 GECVRTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLtTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 238 DLKQGNPIHVLkgtEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 317
Cdd:cd00200  163 DLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG------------------ 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564368942 318 LGFCSVMP---LAAVGYLDGTLAIYDLSTQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGVVRLWD 381
Cdd:cd00200  222 VNSVAFSPdgyLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
81-421 1.34e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.17  E-value: 1.34e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942  81 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVET 160
Cdd:COG2319   73 TLLGHTAAVLSVAFSPDGRLLA-SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 161 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 237
Cdd:COG2319  152 GKLLRTLTghSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 238 DLKQGNPIHVLKGtegHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 317
Cdd:COG2319  232 DLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG------------------ 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 318 lgfcsVMPLA--------AVGYLDGTLAIYDLSTQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGVVRLWDARTGRLL 388
Cdd:COG2319  291 -----VNSVAfspdgkllASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365

                        330       340       350
                 ....*....|....*....|....*....|...
gi 564368942 389 TDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 421
Cdd:COG2319  366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
81-421 1.94e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.30  E-value: 1.94e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942  81 TFALHSASVFCVSLDPkTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVET 160
Cdd:COG2319   31 LLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 161 KEEVWSFEA--GDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 237
Cdd:COG2319  110 GLLLRTLTGhtGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 238 DLKQGNPIHVLKgteGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETvasqpslgegeesesnsvES 317
Cdd:COG2319  190 DLATGKLLRTLT---GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS------------------GS 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 318 LGFCSVMP---LAAVGYLDGTLAIYDLSTQTLRHQCQHQSGIVqllweagTAVVY--------TCSLDGVVRLWDARTGR 386
Cdd:COG2319  249 VRSVAFSPdgrLLASGSADGTVRLWDLATGELLRTLTGHSGGV-------NSVAFspdgkllaSGSDDGTVRLWDLATGK 321

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 564368942 387 LLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 421
Cdd:COG2319  322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
101-422 2.65e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.35  E-value: 2.65e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 101 LAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVETKEEVWSFE--AGDLEWMEWH 178
Cdd:COG2319    8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLghTAAVLSVAFS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 179 PRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGNPIHVLKGtegHQGP 257
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLrTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG---HSGA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 258 LTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsveslgfcsVMPLA--------AV 329
Cdd:COG2319  165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-----------------------VRSVAfspdgkllAS 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 330 GYLDGTLAIYDLSTQTLRHQCQHQSGIVQ-LLWEAGTAVVYTCSLDGVVRLWDARTGRLLTDYRGHTAEILDFALSKDAS 408
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRsVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK 301

                        330
                 ....*....|....
gi 564368942 409 LVVTTSGDHKAKVF 422
Cdd:COG2319  302 LLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 320-425 2.27e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 2.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 320 FCSVMPLAAVGYLDGTLAIYDLST-QTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGVVRLWDARTGRLLTDYRGHTAEI 398
Cdd:cd00200   17 FSPDGKLLATGSGDGTIKVWDLETgELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYV 96

                         90       100
                 ....*....|....*....|....*..
gi 564368942 399 LDFALSKDASLVVTTSGDHKAKVFCVQ 425
Cdd:cd00200   97 SSVAFSPDGRILSSSSRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
217-425 4.70e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.33  E-value: 4.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 217 RVLPDGKRAVVGYEDGTIRIWDLKQGNPIHVLkgtEGHQGPLTCVATNQDGSLILTGSVDCQAKLVSATTGKVVGVFRPE 296
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLL---LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942 297 TVAsqpslgegeesesnsVESLGFCSVMPLAAVGYLDGTLAIYDLSTQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDG 375
Cdd:COG2319   78 TAA---------------VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADG 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 564368942 376 VVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQ 425
Cdd:COG2319  143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 118-156 4.87e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.87e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 564368942   118 DGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 156
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
119-156 3.59e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 3.59e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 564368942  119 GELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 156
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 175-261 5.30e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.88  E-value: 5.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564368942  175 MEWHPRAPVLLAGTADGNTWM--------WKVPNGdcktfqGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGNPIH 246
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLhrlnwqrvWTLSPD------KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVH 74

                          90
                  ....*....|....*
gi 564368942  247 VLKgteGHQGPLTCV 261
Cdd:pfam12894  75 HFS---AGSDLITCL 86
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 203-238 2.38e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.38e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 564368942   203 CKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWD 238
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 241-281 3.11e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.11e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 564368942   241 QGNPIHVLKGtegHQGPLTCVATNQDGSLILTGSVDCQAKL 281
Cdd:smart00320   1 SGELLKTLKG---HTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
242-281 5.86e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 5.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 564368942  242 GNPIHVLKGtegHQGPLTCVATNQDGSLILTGSVDCQAKL 281
Cdd:pfam00400   1 GKLLKTLEG---HTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 384-422 1.37e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.37e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 564368942   384 TGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 422
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
204-238 3.85e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 3.85e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 564368942  204 KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWD 238
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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