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Conserved domains on  [gi|564376350|ref|XP_006248217|]
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immunoglobulin superfamily member 5 isoform X1 [Rattus norvegicus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12209963)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 31-126 2.60e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 50.58  E-value: 2.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564376350    31 PRNVTALKGSEARFNCTVTHGWKLIMWalngiveLSLTSQKPIITSNRFTSasynSTDSFISEMIIHNVQLNDSGPVQCS 110
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVT-------WYKQGGKLLAESGRFSV----SRSGSTSTLTISNVTPEDSGTYTCA 69

                           90
                   ....*....|....*.
gi 564376350   111 LQNSNVFGFAFLSVQV 126
Cdd:smart00410  70 ATNSSGSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 129-204 6.77e-07

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 46.40  E-value: 6.77e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564376350  129 TLNIPSSNLIVTEGEPCNVTCYAVGwTPLPNISWELEVPVSHSSYYSFLEPGNSLRVLSVLDLTPLGNGTLTCVAE 204
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATG-SPPPTITWYKNGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 31-126 2.60e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 50.58  E-value: 2.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564376350    31 PRNVTALKGSEARFNCTVTHGWKLIMWalngiveLSLTSQKPIITSNRFTSasynSTDSFISEMIIHNVQLNDSGPVQCS 110
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVT-------WYKQGGKLLAESGRFSV----SRSGSTSTLTISNVTPEDSGTYTCA 69

                           90
                   ....*....|....*.
gi 564376350   111 LQNSNVFGFAFLSVQV 126
Cdd:smart00410  70 ATNSSGSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 129-204 6.77e-07

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 46.40  E-value: 6.77e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564376350  129 TLNIPSSNLIVTEGEPCNVTCYAVGwTPLPNISWELEVPVSHSSYYSFLEPGNSLRVLSVLDLTPLGNGTLTCVAE 204
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATG-SPPPTITWYKNGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77
I-set pfam07679
Immunoglobulin I-set domain;
26-114 7.15e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 43.79  E-value: 7.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564376350   26 QIIEGPRNVTALKGSEARFNCTVThGWKL--IMWALNGivelsltsqKPIITSNRFtSASYnstDSFISEMIIHNVQLND 103
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCTVT-GTPDpeVSWFKDG---------QPLRSSDRF-KVTY---EGGTYTLTISNVQPDD 67

                          90
                  ....*....|.
gi 564376350  104 SGPVQCSLQNS 114
Cdd:pfam07679  68 SGKYTCVATNS 78
IgI_2_Palladin_C cd20990
Second C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig ...
 136-214 1.00e-04

Second C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the C-terminal immunoglobulin (Ig)-like domain of palladin. Palladin belongs to the palladin-myotilin-myopalladin family. Proteins belonging to this family contain multiple Ig-like domains and function as scaffolds, modulating actin cytoskeleton. Palladin binds to alpha-actinin ezrin, vasodilator-stimulated phosphoprotein VASP, SPIN90 (also known as DIP or mDia interacting protein), and Src. Palladin also binds F-actin directly, via its Ig3 domain. Palladin is expressed as several alternatively spliced isoforms, having various combinations of Ig-like domains, in a cell-type-specific manner. It has been suggested that palladin's different Ig-like domains may be specialized for distinct functions. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409582  Cd Length: 91  Bit Score: 40.85  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564376350 136 NLIVTEGEPCNVTCYAVGwTPLPNISWELE-VPVSHSSYYSFLEPGNSLRVLSVLDLTPLGNGTLTCVAEMKDLQASESL 214
Cdd:cd20990    9 DLTVQEGKLCRMDCKVSG-LPTPDLSWQLDgKPIRPDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFNL 87
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 31-126 2.60e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 50.58  E-value: 2.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564376350    31 PRNVTALKGSEARFNCTVTHGWKLIMWalngiveLSLTSQKPIITSNRFTSasynSTDSFISEMIIHNVQLNDSGPVQCS 110
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVT-------WYKQGGKLLAESGRFSV----SRSGSTSTLTISNVTPEDSGTYTCA 69

                           90
                   ....*....|....*.
gi 564376350   111 LQNSNVFGFAFLSVQV 126
Cdd:smart00410  70 ATNSSGSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 129-204 6.77e-07

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 46.40  E-value: 6.77e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564376350  129 TLNIPSSNLIVTEGEPCNVTCYAVGwTPLPNISWELEVPVSHSSYYSFLEPGNSLRVLSVLDLTPLGNGTLTCVAE 204
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATG-SPPPTITWYKNGEPISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77
I-set pfam07679
Immunoglobulin I-set domain;
26-114 7.15e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 43.79  E-value: 7.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564376350   26 QIIEGPRNVTALKGSEARFNCTVThGWKL--IMWALNGivelsltsqKPIITSNRFtSASYnstDSFISEMIIHNVQLND 103
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCTVT-GTPDpeVSWFKDG---------QPLRSSDRF-KVTY---EGGTYTLTISNVQPDD 67

                          90
                  ....*....|.
gi 564376350  104 SGPVQCSLQNS 114
Cdd:pfam07679  68 SGKYTCVATNS 78
I-set pfam07679
Immunoglobulin I-set domain;
132-220 6.08e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 41.47  E-value: 6.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564376350  132 IPSSNLIVTEGEPCNVTCYAVGwTPLPNISWEL-EVPVSHSSYYSFLEPGNSLRvLSVLDLTPLGNGTLTCVAEMKDLQA 210
Cdd:pfam07679   5 QKPKDVEVQEGESARFTCTVTG-TPDPEVSWFKdGQPLRSSDRFKVTYEGGTYT-LTISNVQPDDSGKYTCVATNSAGEA 82

                          90
                  ....*....|
gi 564376350  211 SEslTVNLTV 220
Cdd:pfam07679  83 EA--SAELTV 90
IgI_2_Palladin_C cd20990
Second C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig ...
 136-214 1.00e-04

Second C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the C-terminal immunoglobulin (Ig)-like domain of palladin. Palladin belongs to the palladin-myotilin-myopalladin family. Proteins belonging to this family contain multiple Ig-like domains and function as scaffolds, modulating actin cytoskeleton. Palladin binds to alpha-actinin ezrin, vasodilator-stimulated phosphoprotein VASP, SPIN90 (also known as DIP or mDia interacting protein), and Src. Palladin also binds F-actin directly, via its Ig3 domain. Palladin is expressed as several alternatively spliced isoforms, having various combinations of Ig-like domains, in a cell-type-specific manner. It has been suggested that palladin's different Ig-like domains may be specialized for distinct functions. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409582  Cd Length: 91  Bit Score: 40.85  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564376350 136 NLIVTEGEPCNVTCYAVGwTPLPNISWELE-VPVSHSSYYSFLEPGNSLRVLSVLDLTPLGNGTLTCVAEMKDLQASESL 214
Cdd:cd20990    9 DLTVQEGKLCRMDCKVSG-LPTPDLSWQLDgKPIRPDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFNL 87
IgI_3_Robo cd05725
Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 133-216 1.78e-04

Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409390 [Multi-domain]  Cd Length: 83  Bit Score: 39.69  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564376350 133 PSSNLIVTEGEPCNVTCyAVGWTPLPNISW---ELEVPVSHssyYSFLEpGNSLRVLSVldlTPLGNGTLTCVAE--MKD 207
Cdd:cd05725    3 RPQNQVVLVDDSAEFQC-EVGGDPVPTVRWrkeDGELPKGR---YEILD-DHSLKIRKV---TAGDMGSYTCVAEnmVGK 74


                 ....*....
gi 564376350 208 LQASESLTV 216
Cdd:cd05725   75 IEASATLTV 83
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 26-113 3.41e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 38.70  E-value: 3.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564376350   26 QIIEGPRNVTALKGSEARFNCTVTHGWK-LIMWALNGIVELSltsqkpiitsnrfTSASYNSTDSFISEMIIHNVQLNDS 104
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPpTITWYKNGEPISS-------------GSTRSRSLSGSNSTLTISNVTRSDA 69


                  ....*....
gi 564376350  105 GPVQCSLQN 113
Cdd:pfam13927  70 GTYTCVASN 78
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 132-211 5.16e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 35.63  E-value: 5.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564376350  132 IPSSNLIVTEGEPCNVTCYAVGWTPLPNISWELEVPVSHSSYYSFLEPGNSLR-VLSVLDLTPLGNGTLTCVAEMKDLQA 210
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTWSKEGGTLIESLKVKHDNGRTTQsSLLISNVTKEDAGTYTCVVNNPGGSA 80


                  .
gi 564376350  211 S 211
Cdd:pfam00047  81 T 81
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 132-220 6.96e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 35.06  E-value: 6.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564376350  132 IPSSNLIVTEGEPCNVTCYAVGWtPLPNISW---ELEVPVSHSSYYSFLEPGNSlrvlsvldltplgnGTLTCVAEMKDL 208
Cdd:pfam13895   4 LTPSPTVVTEGEPVTLTCSAPGN-PPPSYTWykdGSAISSSPNFFTLSVSAEDS--------------GTYTCVARNGRG 68

                          90
                  ....*....|..
gi 564376350  209 QASeSLTVNLTV 220
Cdd:pfam13895  69 GKV-SNPVELTV 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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