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Conserved domains on  [gi|564379611|ref|XP_006249488|]
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calcineurin B homologous protein 3 isoform X1 [Rattus norvegicus]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 12144950)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494
SCOP:  3001983

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EFh super family cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 147-175 2.31e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


The actual alignment was detected with superfamily member cd00051:

Pssm-ID: 415501 [Multi-domain]  Cd Length: 63  Bit Score: 38.30  E-value: 2.31e-04
                         10        20
                 ....*....|....*....|....*....
gi 564379611 147 KLKFLFHMYDSDSDGRITLEEYRNVVEEL 175
Cdd:cd00051    1 ELREAFRLFDKDGDGTISADELKAALKSL 29
EF-hand_7 pfam13499
EF-hand domain pair;
145-225 4.26e-04

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 37.62  E-value: 4.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564379611  145 KEKLKFLFHMYDSDSDGRITLEEYRNVVEELLSGNPhIEKESARSIADgammeaasvcvgQMEPDQvyEG-ITFEDFLKI 223
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEP-LSDEEVEELFK------------EFDLDK--DGrISFEEFLEL 65


                  ..
gi 564379611  224 WQ 225
Cdd:pfam13499  66 YS 67
EF-hand_7 pfam13499
EF-hand domain pair;
92-172 8.54e-03

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 34.15  E-value: 8.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564379611   92 RSKIVRAF--FDNRNlrkgsSGLadeINFEDFltiMSYFRPIdttlgEEQVELSRKEkLKFLFHMYDSDSDGRITLEEYR 169
Cdd:pfam13499   1 EEKLKEAFklLDSDG-----DGY---LDVEEL---KKLLRKL-----EEGEPLSDEE-VEELFKEFDLDKDGRISFEEFL 63


                  ...
gi 564379611  170 NVV 172
Cdd:pfam13499  64 ELY 66
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 147-175 2.31e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 38.30  E-value: 2.31e-04
                         10        20
                 ....*....|....*....|....*....
gi 564379611 147 KLKFLFHMYDSDSDGRITLEEYRNVVEEL 175
Cdd:cd00051    1 ELREAFRLFDKDGDGTISADELKAALKSL 29
EF-hand_7 pfam13499
EF-hand domain pair;
145-225 4.26e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 37.62  E-value: 4.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564379611  145 KEKLKFLFHMYDSDSDGRITLEEYRNVVEELLSGNPhIEKESARSIADgammeaasvcvgQMEPDQvyEG-ITFEDFLKI 223
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEP-LSDEEVEELFK------------EFDLDK--DGrISFEEFLEL 65


                  ..
gi 564379611  224 WQ 225
Cdd:pfam13499  66 YS 67
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
114-183 6.12e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.00  E-value: 6.12e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564379611 114 DEINFEDFLTIMsyfrpidttlgEEQVELSRKEKLKFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIE 183
Cdd:COG5126   48 GRISREEFVAGM-----------ESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGVSEEEAD 106
PTZ00183 PTZ00183
centrin; Provisional
 86-223 1.07e-03

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 38.52  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564379611  86 LELNPIRSKIVRAFFDnrnLRKGSSGladEINFEDFLTIMSyfrpidTTLGEEQvelSRKEKLKfLFHMYDSDSDGRITL 165
Cdd:PTZ00183  46 LGFEPKKEEIKQMIAD---VDKDGSG---KIDFEEFLDIMT------KKLGERD---PREEILK-AFRLFDDDKTGKISL 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564379611 166 EEYRNVVEELlsgNPHIEKESARSIADgammeaasvcvgqmEPDQVYEG-ITFEDFLKI 223
Cdd:PTZ00183 110 KNLKRVAKEL---GETITDEELQEMID--------------EADRNGDGeISEEEFYRI 151
EF-hand_6 pfam13405
EF-hand domain;
147-175 1.75e-03

EF-hand domain;


Pssm-ID: 463869 [Multi-domain]  Cd Length: 30  Bit Score: 34.84  E-value: 1.75e-03
                          10        20
                  ....*....|....*....|....*....
gi 564379611  147 KLKFLFHMYDSDSDGRITLEEYRNVVEEL 175
Cdd:pfam13405   1 ELREAFKLFDKDGDGKISLEELRKALRSL 29
EFh smart00054
EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in ...
 147-175 3.67e-03

EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in pairs. Links between disease states and genes encoding EF-hands, particularly the S100 subclass, are emerging. Each motif consists of a 12 residue loop flanked on either side by a 12 residue alpha-helix. EF-hands undergo a conformational change unpon binding calcium ions.


Pssm-ID: 197492 [Multi-domain]  Cd Length: 29  Bit Score: 33.89  E-value: 3.67e-03
                           10        20
                   ....*....|....*....|....*....
gi 564379611   147 KLKFLFHMYDSDSDGRITLEEYRNVVEEL 175
Cdd:smart00054   1 ELKEAFRLFDKDGDGKIDFEEFKDLLKAL 29
EF-hand_7 pfam13499
EF-hand domain pair;
92-172 8.54e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 34.15  E-value: 8.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564379611   92 RSKIVRAF--FDNRNlrkgsSGLadeINFEDFltiMSYFRPIdttlgEEQVELSRKEkLKFLFHMYDSDSDGRITLEEYR 169
Cdd:pfam13499   1 EEKLKEAFklLDSDG-----DGY---LDVEEL---KKLLRKL-----EEGEPLSDEE-VEELFKEFDLDKDGRISFEEFL 63


                  ...
gi 564379611  170 NVV 172
Cdd:pfam13499  64 ELY 66
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 147-175 2.31e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 38.30  E-value: 2.31e-04
                         10        20
                 ....*....|....*....|....*....
gi 564379611 147 KLKFLFHMYDSDSDGRITLEEYRNVVEEL 175
Cdd:cd00051    1 ELREAFRLFDKDGDGTISADELKAALKSL 29
EF-hand_7 pfam13499
EF-hand domain pair;
145-225 4.26e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 37.62  E-value: 4.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564379611  145 KEKLKFLFHMYDSDSDGRITLEEYRNVVEELLSGNPhIEKESARSIADgammeaasvcvgQMEPDQvyEG-ITFEDFLKI 223
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEP-LSDEEVEELFK------------EFDLDK--DGrISFEEFLEL 65


                  ..
gi 564379611  224 WQ 225
Cdd:pfam13499  66 YS 67
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
114-183 6.12e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.00  E-value: 6.12e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564379611 114 DEINFEDFLTIMsyfrpidttlgEEQVELSRKEKLKFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIE 183
Cdd:COG5126   48 GRISREEFVAGM-----------ESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGVSEEEAD 106
PTZ00183 PTZ00183
centrin; Provisional
 86-223 1.07e-03

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 38.52  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564379611  86 LELNPIRSKIVRAFFDnrnLRKGSSGladEINFEDFLTIMSyfrpidTTLGEEQvelSRKEKLKfLFHMYDSDSDGRITL 165
Cdd:PTZ00183  46 LGFEPKKEEIKQMIAD---VDKDGSG---KIDFEEFLDIMT------KKLGERD---PREEILK-AFRLFDDDKTGKISL 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 564379611 166 EEYRNVVEELlsgNPHIEKESARSIADgammeaasvcvgqmEPDQVYEG-ITFEDFLKI 223
Cdd:PTZ00183 110 KNLKRVAKEL---GETITDEELQEMID--------------EADRNGDGeISEEEFYRI 151
EF-hand_6 pfam13405
EF-hand domain;
147-175 1.75e-03

EF-hand domain;


Pssm-ID: 463869 [Multi-domain]  Cd Length: 30  Bit Score: 34.84  E-value: 1.75e-03
                          10        20
                  ....*....|....*....|....*....
gi 564379611  147 KLKFLFHMYDSDSDGRITLEEYRNVVEEL 175
Cdd:pfam13405   1 ELREAFKLFDKDGDGKISLEELRKALRSL 29
EF-hand_1 pfam00036
EF hand; The EF-hands can be divided into two classes: signalling proteins and buffering ...
 147-175 2.17e-03

EF hand; The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.


Pssm-ID: 425435 [Multi-domain]  Cd Length: 29  Bit Score: 34.68  E-value: 2.17e-03
                          10        20
                  ....*....|....*....|....*....
gi 564379611  147 KLKFLFHMYDSDSDGRITLEEYRNVVEEL 175
Cdd:pfam00036   1 ELKEIFRLFDKDGDGKIDFEEFKELLKKL 29
EFh smart00054
EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in ...
 147-175 3.67e-03

EF-hand, calcium binding motif; EF-hands are calcium-binding motifs that occur at least in pairs. Links between disease states and genes encoding EF-hands, particularly the S100 subclass, are emerging. Each motif consists of a 12 residue loop flanked on either side by a 12 residue alpha-helix. EF-hands undergo a conformational change unpon binding calcium ions.


Pssm-ID: 197492 [Multi-domain]  Cd Length: 29  Bit Score: 33.89  E-value: 3.67e-03
                           10        20
                   ....*....|....*....|....*....
gi 564379611   147 KLKFLFHMYDSDSDGRITLEEYRNVVEEL 175
Cdd:smart00054   1 ELKEAFRLFDKDGDGKIDFEEFKDLLKAL 29
EF-hand_7 pfam13499
EF-hand domain pair;
92-172 8.54e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 34.15  E-value: 8.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564379611   92 RSKIVRAF--FDNRNlrkgsSGLadeINFEDFltiMSYFRPIdttlgEEQVELSRKEkLKFLFHMYDSDSDGRITLEEYR 169
Cdd:pfam13499   1 EEKLKEAFklLDSDG-----DGY---LDVEEL---KKLLRKL-----EEGEPLSDEE-VEELFKEFDLDKDGRISFEEFL 63


                  ...
gi 564379611  170 NVV 172
Cdd:pfam13499  64 ELY 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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