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Conserved domains on  [gi|564387870|ref|XP_006252659|]
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voltage-dependent L-type calcium channel subunit alpha-1D isoform X16 [Rattus norvegicus]

Protein Classification

Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type calcium channel subunit alpha-1; voltage-dependent L-type calcium channel subunit alpha-1( domain architecture ID 11999372)

Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-417 6.46e-69

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 232.16  E-value: 6.46e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   125 WKPFDIFILLAIFANCVALAIYIPFPEDDSnsTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHpnaYVRNGWNLLDFVI 204
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   205 VIVGLFSVILeqltketeggnhsSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Cdd:pfam00520   76 VLPSLISLVL-------------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   285 YAIIGLELFIGKMHKtcffadsdivaeedpapcafsgngrqcaangtecrsgWVGPNGGITNFDNFAFAMLTVFQCITME 364
Cdd:pfam00520  143 FAIIGYQLFGGKLKT-------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTE 185
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 564387870   365 GWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 417
Cdd:pfam00520  186 GWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1204-1460 1.52e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 225.22  E-value: 1.52e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1204 SSPFEYMMFVLIMLNTLCLAMQHYEQSKM-FNDAMDILNMVFTGVFTVEMVLKVIAFKPKG-YFSDAWNTFDSLIVIGSI 1281
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1282 IDVALSEAdnseeSNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVA 1361
Cdd:pfam00520   81 ISLVLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1362 MRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKlcdpdsdynpgeeytcGSNFAIVYFISFYMLCAFLII 1441
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLL 219
                          250
                   ....*....|....*....
gi 564387870  1442 NLFVAVIMDNFDYLTRDWS 1460
Cdd:pfam00520  220 NLFIAVIIDNFQELTERTE 238
CAC1F_C super family cl25181
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1627-2134 3.20e-55

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


The actual alignment was detected with superfamily member pfam16885:

Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 197.15  E-value: 3.20e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1627 AGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNgallgnyvnhvnsDRRESLQQTNTTHRPLHVQRPsippas 1706
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEEEEDSK-------------DPKAPIGSQPPSRSRISVSLP------ 61
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1707 dtekplfppagnsvchnhhnhnsIGKQVPTSTNAnlnnanmskaahgkRPSIGDlehvsenghysykhdrelqRRSSIKR 1786
Cdd:pfam16885   62 -----------------------VGDRLPDSLSL--------------GPSDDD-------------------GGAPNSR 85
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1787 SESGDEQLPTICREDPEIhgyfrdpRCFGEQEYFSS--------EECCEDDSSPTWsRQNYSYYNRYPGSSMDFERPRGY 1858
Cdd:pfam16885   86 QPSVPQTGSHTHRRSSGV-------LMFTIPEEGSSqpkgtkgqDKQDEEEEVPDQ-LSYLDEQAGTPSRPVLLPPHRPQ 157
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1859 HHPQGFLEDDDS---PIgydsrrsprrrllpptpPSHRRSSFNFECLRRQNSQDDvLPSPALPHRAalplhlmqqqimav 1935
Cdd:pfam16885  158 HYPLREPVDRRRllpPT-----------------PAGRKPSFNIQCLRRQGSCED-LPIPGTYHRG-------------- 205
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1936 agldsskaQKYSPSHSTRSWATPPatppyRDWTPCYTPLIQVDRSESMDQVNGSLPSlhrsswytdepdiSYRTFTpaSL 2015
Cdd:pfam16885  206 --------RNSGPSRAQGSWATPP-----QRGRLLYAPLLLVEEGAAGEGYLGKSPG-------------PLRTFT--CL 257
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  2016 TVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNgsvcprangdmgp 2095
Cdd:pfam16885  258 RVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLA------------- 324
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 564387870  2096 ishrqdyelQDFGPGYSDEEPD-PGREEEDLADEMICITT 2134
Cdd:pfam16885  325 ---------QGTSSLYSDEESIlSSFDEEDLGDEMACVHA 355
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
885-1162 2.85e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.47  E-value: 2.85e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   885 HHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHkgaFCRNYFNLLDMLVVG 964
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   965 VSLVSFGIQS-SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYR 1043
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1044 CTDEaksnpeecrglfilykdgdvdspvvreriwQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVY- 1122
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIYf 207
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 564387870  1123 -------NYrveisiffiiyiiivafFMMNIFVGFVIVTFQEQGEKE 1162
Cdd:pfam00520  208 vsfiilgGF-----------------LLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
525-760 4.05e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 180.93  E-value: 4.05e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   525 FYWLVIVLVFLNTLTISSEHYNQPDW-LTQIQDIANKVLLALFTCEMLVKMYSLGL-QAYFVSLFNRFDCFVVCGGITEt 602
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLIS- 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   603 iLVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-NFDET 681
Cdd:pfam00520   83 -LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTWENP 161
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564387870   682 QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGgpsssGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 760
Cdd:pfam00520  162 DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1532-1606 3.50e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


:

Pssm-ID: 462591  Cd Length: 77  Bit Score: 135.03  E-value: 3.50e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564387870  1532 NATLFALVRTALKIKTE--GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKK 1606
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1469-1522 8.83e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 115.83  E-value: 8.83e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 564387870  1469 EFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMP 1522
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-417 6.46e-69

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 232.16  E-value: 6.46e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   125 WKPFDIFILLAIFANCVALAIYIPFPEDDSnsTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHpnaYVRNGWNLLDFVI 204
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   205 VIVGLFSVILeqltketeggnhsSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Cdd:pfam00520   76 VLPSLISLVL-------------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   285 YAIIGLELFIGKMHKtcffadsdivaeedpapcafsgngrqcaangtecrsgWVGPNGGITNFDNFAFAMLTVFQCITME 364
Cdd:pfam00520  143 FAIIGYQLFGGKLKT-------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTE 185
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 564387870   365 GWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 417
Cdd:pfam00520  186 GWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1204-1460 1.52e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 225.22  E-value: 1.52e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1204 SSPFEYMMFVLIMLNTLCLAMQHYEQSKM-FNDAMDILNMVFTGVFTVEMVLKVIAFKPKG-YFSDAWNTFDSLIVIGSI 1281
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1282 IDVALSEAdnseeSNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVA 1361
Cdd:pfam00520   81 ISLVLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1362 MRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKlcdpdsdynpgeeytcGSNFAIVYFISFYMLCAFLII 1441
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLL 219
                          250
                   ....*....|....*....
gi 564387870  1442 NLFVAVIMDNFDYLTRDWS 1460
Cdd:pfam00520  220 NLFIAVIIDNFQELTERTE 238
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1627-2134 3.20e-55

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 197.15  E-value: 3.20e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1627 AGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNgallgnyvnhvnsDRRESLQQTNTTHRPLHVQRPsippas 1706
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEEEEDSK-------------DPKAPIGSQPPSRSRISVSLP------ 61
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1707 dtekplfppagnsvchnhhnhnsIGKQVPTSTNAnlnnanmskaahgkRPSIGDlehvsenghysykhdrelqRRSSIKR 1786
Cdd:pfam16885   62 -----------------------VGDRLPDSLSL--------------GPSDDD-------------------GGAPNSR 85
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1787 SESGDEQLPTICREDPEIhgyfrdpRCFGEQEYFSS--------EECCEDDSSPTWsRQNYSYYNRYPGSSMDFERPRGY 1858
Cdd:pfam16885   86 QPSVPQTGSHTHRRSSGV-------LMFTIPEEGSSqpkgtkgqDKQDEEEEVPDQ-LSYLDEQAGTPSRPVLLPPHRPQ 157
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1859 HHPQGFLEDDDS---PIgydsrrsprrrllpptpPSHRRSSFNFECLRRQNSQDDvLPSPALPHRAalplhlmqqqimav 1935
Cdd:pfam16885  158 HYPLREPVDRRRllpPT-----------------PAGRKPSFNIQCLRRQGSCED-LPIPGTYHRG-------------- 205
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1936 agldsskaQKYSPSHSTRSWATPPatppyRDWTPCYTPLIQVDRSESMDQVNGSLPSlhrsswytdepdiSYRTFTpaSL 2015
Cdd:pfam16885  206 --------RNSGPSRAQGSWATPP-----QRGRLLYAPLLLVEEGAAGEGYLGKSPG-------------PLRTFT--CL 257
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  2016 TVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNgsvcprangdmgp 2095
Cdd:pfam16885  258 RVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLA------------- 324
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 564387870  2096 ishrqdyelQDFGPGYSDEEPD-PGREEEDLADEMICITT 2134
Cdd:pfam16885  325 ---------QGTSSLYSDEESIlSSFDEEDLGDEMACVHA 355
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
885-1162 2.85e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.47  E-value: 2.85e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   885 HHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHkgaFCRNYFNLLDMLVVG 964
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   965 VSLVSFGIQS-SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYR 1043
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1044 CTDEaksnpeecrglfilykdgdvdspvvreriwQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVY- 1122
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIYf 207
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 564387870  1123 -------NYrveisiffiiyiiivafFMMNIFVGFVIVTFQEQGEKE 1162
Cdd:pfam00520  208 vsfiilgGF-----------------LLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
525-760 4.05e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 180.93  E-value: 4.05e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   525 FYWLVIVLVFLNTLTISSEHYNQPDW-LTQIQDIANKVLLALFTCEMLVKMYSLGL-QAYFVSLFNRFDCFVVCGGITEt 602
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLIS- 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   603 iLVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-NFDET 681
Cdd:pfam00520   83 -LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTWENP 161
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564387870   682 QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGgpsssGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 760
Cdd:pfam00520  162 DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1532-1606 3.50e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 135.03  E-value: 3.50e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564387870  1532 NATLFALVRTALKIKTE--GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKK 1606
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1469-1522 8.83e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 115.83  E-value: 8.83e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 564387870  1469 EFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMP 1522
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1584-1614 1.61e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 66.09  E-value: 1.61e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 564387870   1584 DEVTVGKFYATFLIQDYFRKFKKRKEQGLVG 1614
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-417 6.46e-69

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 232.16  E-value: 6.46e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   125 WKPFDIFILLAIFANCVALAIYIPFPEDDSnsTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHpnaYVRNGWNLLDFVI 204
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   205 VIVGLFSVILeqltketeggnhsSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Cdd:pfam00520   76 VLPSLISLVL-------------SSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   285 YAIIGLELFIGKMHKtcffadsdivaeedpapcafsgngrqcaangtecrsgWVGPNGGITNFDNFAFAMLTVFQCITME 364
Cdd:pfam00520  143 FAIIGYQLFGGKLKT-------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTE 185
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 564387870   365 GWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 417
Cdd:pfam00520  186 GWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1204-1460 1.52e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 225.22  E-value: 1.52e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1204 SSPFEYMMFVLIMLNTLCLAMQHYEQSKM-FNDAMDILNMVFTGVFTVEMVLKVIAFKPKG-YFSDAWNTFDSLIVIGSI 1281
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1282 IDVALSEAdnseeSNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVA 1361
Cdd:pfam00520   81 ISLVLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1362 MRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKlcdpdsdynpgeeytcGSNFAIVYFISFYMLCAFLII 1441
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLL 219
                          250
                   ....*....|....*....
gi 564387870  1442 NLFVAVIMDNFDYLTRDWS 1460
Cdd:pfam00520  220 NLFIAVIIDNFQELTERTE 238
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1627-2134 3.20e-55

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 197.15  E-value: 3.20e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1627 AGLRTLHDIGPEIRRAISCDLQDDEPEDSKPEEEDVFKRNgallgnyvnhvnsDRRESLQQTNTTHRPLHVQRPsippas 1706
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEEEEDSK-------------DPKAPIGSQPPSRSRISVSLP------ 61
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1707 dtekplfppagnsvchnhhnhnsIGKQVPTSTNAnlnnanmskaahgkRPSIGDlehvsenghysykhdrelqRRSSIKR 1786
Cdd:pfam16885   62 -----------------------VGDRLPDSLSL--------------GPSDDD-------------------GGAPNSR 85
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1787 SESGDEQLPTICREDPEIhgyfrdpRCFGEQEYFSS--------EECCEDDSSPTWsRQNYSYYNRYPGSSMDFERPRGY 1858
Cdd:pfam16885   86 QPSVPQTGSHTHRRSSGV-------LMFTIPEEGSSqpkgtkgqDKQDEEEEVPDQ-LSYLDEQAGTPSRPVLLPPHRPQ 157
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1859 HHPQGFLEDDDS---PIgydsrrsprrrllpptpPSHRRSSFNFECLRRQNSQDDvLPSPALPHRAalplhlmqqqimav 1935
Cdd:pfam16885  158 HYPLREPVDRRRllpPT-----------------PAGRKPSFNIQCLRRQGSCED-LPIPGTYHRG-------------- 205
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1936 agldsskaQKYSPSHSTRSWATPPatppyRDWTPCYTPLIQVDRSESMDQVNGSLPSlhrsswytdepdiSYRTFTpaSL 2015
Cdd:pfam16885  206 --------RNSGPSRAQGSWATPP-----QRGRLLYAPLLLVEEGAAGEGYLGKSPG-------------PLRTFT--CL 257
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  2016 TVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNgsvcprangdmgp 2095
Cdd:pfam16885  258 RVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLA------------- 324
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 564387870  2096 ishrqdyelQDFGPGYSDEEPD-PGREEEDLADEMICITT 2134
Cdd:pfam16885  325 ---------QGTSSLYSDEESIlSSFDEEDLGDEMACVHA 355
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
885-1162 2.85e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.47  E-value: 2.85e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   885 HHIFTNLILVFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHkgaFCRNYFNLLDMLVVG 964
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   965 VSLVSFGIQS-SAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYR 1043
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1044 CTDEaksnpeecrglfilykdgdvdspvvreriwQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVY- 1122
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIYf 207
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 564387870  1123 -------NYrveisiffiiyiiivafFMMNIFVGFVIVTFQEQGEKE 1162
Cdd:pfam00520  208 vsfiilgGF-----------------LLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
525-760 4.05e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 180.93  E-value: 4.05e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   525 FYWLVIVLVFLNTLTISSEHYNQPDW-LTQIQDIANKVLLALFTCEMLVKMYSLGL-QAYFVSLFNRFDCFVVCGGITEt 602
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLIS- 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   603 iLVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF-NFDET 681
Cdd:pfam00520   83 -LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTWENP 161
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564387870   682 QTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGgpsssGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAES 760
Cdd:pfam00520  162 DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1532-1606 3.50e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 135.03  E-value: 3.50e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564387870  1532 NATLFALVRTALKIKTE--GNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKK 1606
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1469-1522 8.83e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 115.83  E-value: 8.83e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 564387870  1469 EFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMP 1522
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1584-1614 1.61e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 66.09  E-value: 1.61e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 564387870   1584 DEVTVGKFYATFLIQDYFRKFKKRKEQGLVG 1614
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1228-1453 2.86e-06

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 50.74  E-value: 2.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1228 EQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKgYFSDAWNTFDSLIVIGSIIDVAL-----SEADN----------- 1291
Cdd:pfam08016    4 TNRSLFILLCEIVFVVFFLYFVVEEILKIRKHRPS-YLRSVWNLLDLAIVILSVVLIVLniyrdFLADRliksveaspvt 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1292 ---------SEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAm 1362
Cdd:pfam08016   83 fidfdrvaqLDNLYRIILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQA- 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870  1363 rdnnqinrnNNFQTFPQAVLLLFRcatgeawqeimlaclpgkLCDPDSDYNpgEEYTCGSNFAIVYFISFYMLCAFLIIN 1442
Cdd:pfam08016  162 ---------PNFSNFVKSILTLFR------------------TILGDFGYN--EIFSGNRVLGPLLFLTFVFLVIFILLN 212
                          250
                   ....*....|.
gi 564387870  1443 LFVAVIMDNFD 1453
Cdd:pfam08016  213 LFLAIINDSYV 223
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
168-293 4.01e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 41.11  E-value: 4.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564387870   168 FLIIFTVETFLKIiayglLLHPNAYVRNGWNLLDFVIVIVGLFSVIL--------EQLTKETEggnHSSGKSGGFD---- 235
Cdd:pfam08016   20 FFLYFVVEEILKI-----RKHRPSYLRSVWNLLDLAIVILSVVLIVLniyrdflaDRLIKSVE---ASPVTFIDFDrvaq 91
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564387870   236 -------VKALRAFRV-LRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELF 293
Cdd:pfam08016   92 ldnlyriILAFLVFLTwLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLF 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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