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Conserved domains on  [gi|568910815|ref|XP_006496887|]
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pappalysin-2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 635-832 2.68e-51

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


:

Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 181.00  E-value: 2.68e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815  635 NMLNDF------DDGDCCDPEVTDVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNVYFASSVREDLAGSATWPWDKE 708
Cdd:cd04275    32 DVLNDDysglnaGVDLGIEFVLAGTTRTVNSAWPVFAGSGTEDAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLV 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815  709 A-LSHLGGVVLNPTYYGMLG-----HTNIMIHEVGHVLGLYHVFKGVSerescddpcretvPSMETGDLCADTAPTPKSk 782
Cdd:cd04275   112 SlAFITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHTFQGGS-------------PCCTTGDYVADTPAEASP- 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 568910815  783 LCRDPEPaNDTCGFTLFPgAPFNNYMSYTDDECTDNFTPNQVARMHCYLD 832
Cdd:cd04275   178 SYGCPAG-RDTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQVTRMRSYLD 225
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 283-440 6.67e-23

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


:

Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 96.68  E-value: 6.67e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815   283 IPREAFTVEAWVRPEGGQSNPAIIAGVFdncshtvNDKGWALGIRSGKdkgwrdaRFFFSLRTDRMKKATIVTGhSRYQP 362
Cdd:pfam13385   14 LPTSDFTVSAWVKPDSLPGWARAIISSS-------GGGGYSLGLDGDG-------RLRFAVNGGNGGWDTVTSG-ASVPL 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568910815   363 GMWTHVAATYDGQHTALYVDGTRVASSRDQFGPLNspfmASCRSLILGGDSSEDgHYFRGYLGTLVIWSTALSQTHLQ 440
Cdd:pfam13385   79 GQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPP----GTGGPLYIGRSPGGD-DYFNGLIDEVRIYDRALSAAEIA 151
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 1113-1152 1.23e-12

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


:

Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 63.55  E-value: 1.23e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568910815  1113 GPYCGDGKVERsiGEMCDDGDLLNGDGCSRACELEEGFNC 1152
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
1523-1586 1.69e-05

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.03  E-value: 1.69e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568910815  1523 CEAPPVIPNANLllpHFLEGNHDVGTICKYECKPGYYvkeTSGSqgknkfLKIQCLDDGSWEQG 1586
Cdd:pfam00084    1 CPPPPDIPNGKV---SATKNEYNYGASVSYECDPGYR---LVGS------PTITCQEDGTWSPP 52
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1720-1756 2.50e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 42.70  E-value: 2.50e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 568910815   1720 PDPSLVHC-IQSCEPFQADGWCDTINNRAYCNYDGGDC 1756
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Notch super family cl02419
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 586-613 2.54e-04

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


The actual alignment was detected with superfamily member smart00004:

Pssm-ID: 470573  Cd Length: 38  Bit Score: 40.00  E-value: 2.54e-04
                            10        20
                    ....*....|....*....|....*...
gi 568910815    586 NCEpSKIGNDHCDPECEHPLTGFDGGDC 613
Cdd:smart00004   12 QCW-DKFGDGVCDEECNNAECLWDGGDC 38
 
Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 635-832 2.68e-51

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 181.00  E-value: 2.68e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815  635 NMLNDF------DDGDCCDPEVTDVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNVYFASSVREDLAGSATWPWDKE 708
Cdd:cd04275    32 DVLNDDysglnaGVDLGIEFVLAGTTRTVNSAWPVFAGSGTEDAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLV 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815  709 A-LSHLGGVVLNPTYYGMLG-----HTNIMIHEVGHVLGLYHVFKGVSerescddpcretvPSMETGDLCADTAPTPKSk 782
Cdd:cd04275   112 SlAFITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHTFQGGS-------------PCCTTGDYVADTPAEASP- 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 568910815  783 LCRDPEPaNDTCGFTLFPgAPFNNYMSYTDDECTDNFTPNQVARMHCYLD 832
Cdd:cd04275   178 SYGCPAG-RDTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQVTRMRSYLD 225
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 283-440 6.67e-23

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 96.68  E-value: 6.67e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815   283 IPREAFTVEAWVRPEGGQSNPAIIAGVFdncshtvNDKGWALGIRSGKdkgwrdaRFFFSLRTDRMKKATIVTGhSRYQP 362
Cdd:pfam13385   14 LPTSDFTVSAWVKPDSLPGWARAIISSS-------GGGGYSLGLDGDG-------RLRFAVNGGNGGWDTVTSG-ASVPL 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568910815   363 GMWTHVAATYDGQHTALYVDGTRVASSRDQFGPLNspfmASCRSLILGGDSSEDgHYFRGYLGTLVIWSTALSQTHLQ 440
Cdd:pfam13385   79 GQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPP----GTGGPLYIGRSPGGD-DYFNGLIDEVRIYDRALSAAEIA 151
LamGL smart00560
LamG-like jellyroll fold domain;
287-437 5.22e-19

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 84.78  E-value: 5.22e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815    287 AFTVEAWVRPEGGQSNPAIIagvfdncshtvndKGWALGIRSGKDKgwrDARFFFSLRTDRmKKATIVTGHSRYQPGMWT 366
Cdd:smart00560    2 SFTLEAWVKLESAGGSQPII-------------TGAAVAQPTISEK---ALTFFLRAKSVQ-GWQTARTGATADWIGVWV 64

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568910815    367 HVAATYDGQHT--ALYVDGTRVASSRDQFGPLNSPFMASCRSLiLGGDSsedGHYFRGYLGTLVIWSTALSQT 437
Cdd:smart00560   65 HLAGVYDGGAGklSLYVNGVEVATSETQPSPSSGNLPQGGRIL-LGGAG---GENFSGRLDEVRVYNRALTAR 133
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 1113-1152 1.23e-12

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 63.55  E-value: 1.23e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568910815  1113 GPYCGDGKVERsiGEMCDDGDLLNGDGCSRACELEEGFNC 1152
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
Peptidase_M43 pfam05572
Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a ...
 680-832 1.57e-06

Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a metallo-protease belonging to Merops family M43. It cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II. Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system.


Pssm-ID: 368506  Cd Length: 152  Bit Score: 49.53  E-value: 1.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815   680 NSTHFLNVYFASSVREDL---AGSATWPWDKEALSHLGGVVLNPTY-YGMLGHTN---IMIHEVGHVLGLYHVFKGVSER 752
Cdd:pfam05572   13 DNEKYMNVYIQNDLADGLtnnSGVAWYPDSGMSADGTARVVFNGAYlAADPTSTNfssTLTHEFGHFLGLIHTFEGGCER 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815   753 escddpcretvpsmETGDLCADT-APTPKSKLCRDPEPANdtCGftlfpGAPFN--NYMSYTDdeCTDNFTPNQVARMHC 829
Cdd:pfam05572   93 --------------GEGDKVPDTpSYTGGEVSLRNKDLFN--CN-----GEPINsqNQMDYNG--CYAMFTQDQVDRMVE 149


                   ...
gi 568910815   830 YLD 832
Cdd:pfam05572  150 VLA 152
Sushi pfam00084
Sushi repeat (SCR repeat);
1523-1586 1.69e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.03  E-value: 1.69e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568910815  1523 CEAPPVIPNANLllpHFLEGNHDVGTICKYECKPGYYvkeTSGSqgknkfLKIQCLDDGSWEQG 1586
Cdd:pfam00084    1 CPPPPDIPNGKV---SATKNEYNYGASVSYECDPGYR---LVGS------PTITCQEDGTWSPP 52
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1523-1583 2.17e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.61  E-value: 2.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568910815 1523 CEAPPVIPNANLllpHFLEGNHDVGTICKYECKPGYYVKETSgsqgknkflKIQCLDDGSW 1583
Cdd:cd00033     1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSS---------TITCTENGGW 49
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1720-1756 2.50e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 42.70  E-value: 2.50e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 568910815   1720 PDPSLVHC-IQSCEPFQADGWCDTINNRAYCNYDGGDC 1756
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
MJ1470 COG5306
Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type ...
 264-388 3.87e-05

Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 444105 [Multi-domain]  Cd Length: 529  Bit Score: 48.36  E-value: 3.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815  264 LYFTGKRERLLLRPEVLAEIPREAFTVEAWVRPEGGQSNPAIiagvfdncshtVNDKGWALGIRSGKDkgwrdarfFFSL 343
Cdd:COG5306   175 AQFDGTSPLVVPASPSLALDAGGGFTFSAWIKPAQLDGNAVL-----------YSRRDGANGLDNGAP--------FVEV 235

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 568910815  344 RTDrmkKATIVTGHSRYQPGMWTHVAATYDGQHTALYVDGTRVAS 388
Cdd:COG5306   236 GGA---GGTRSAAGAPLAAGTWHHLAVVADAGKVTLYVNGVAAGS 277
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1523-1583 7.77e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 42.13  E-value: 7.77e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568910815   1523 CEAPPVIPNANLLLPHfleGNHDVGTICKYECKPGYYVKETSgsqgknkflKIQCLDDGSW 1583
Cdd:smart00032    1 CPPPPDIENGTVTSSS---GTYSYGDTVTYSCDPGYTLIGSS---------TITCLENGTW 49
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 586-613 2.54e-04

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 40.00  E-value: 2.54e-04
                            10        20
                    ....*....|....*....|....*...
gi 568910815    586 NCEpSKIGNDHCDPECEHPLTGFDGGDC 613
Cdd:smart00004   12 QCW-DKFGDGVCDEECNNAECLWDGGDC 38
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 323-430 8.21e-03

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 38.94  E-value: 8.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815  323 ALGIRSGKdkgwrdarffFSLRTDRMKKATIVTGHSRYQPGMWTHVAATYDGQHTALYVDGTRVASSRDqfgPLNSPFMA 402
Cdd:cd00110    50 ALELEDGR----------LVLRYDLGSGSLVLSSKTPLNDGQWHSVSVERNGRSVTLSVDGERVVESGS---PGGSALLN 116

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 568910815  403 SCRSLILGG--DSSED-----GHYFRGYLGTLVIW 430
Cdd:cd00110   117 LDGPLYLGGlpEDLKSpglpvSPGFVGCIRDLKVN 151
 
Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 635-832 2.68e-51

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 181.00  E-value: 2.68e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815  635 NMLNDF------DDGDCCDPEVTDVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNVYFASSVREDLAGSATWPWDKE 708
Cdd:cd04275    32 DVLNDDysglnaGVDLGIEFVLAGTTRTVNSAWPVFAGSGTEDAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLV 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815  709 A-LSHLGGVVLNPTYYGMLG-----HTNIMIHEVGHVLGLYHVFKGVSerescddpcretvPSMETGDLCADTAPTPKSk 782
Cdd:cd04275   112 SlAFITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHTFQGGS-------------PCCTTGDYVADTPAEASP- 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 568910815  783 LCRDPEPaNDTCGFTLFPgAPFNNYMSYTDDECTDNFTPNQVARMHCYLD 832
Cdd:cd04275   178 SYGCPAG-RDTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQVTRMRSYLD 225
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 283-440 6.67e-23

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 96.68  E-value: 6.67e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815   283 IPREAFTVEAWVRPEGGQSNPAIIAGVFdncshtvNDKGWALGIRSGKdkgwrdaRFFFSLRTDRMKKATIVTGhSRYQP 362
Cdd:pfam13385   14 LPTSDFTVSAWVKPDSLPGWARAIISSS-------GGGGYSLGLDGDG-------RLRFAVNGGNGGWDTVTSG-ASVPL 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568910815   363 GMWTHVAATYDGQHTALYVDGTRVASSRDQFGPLNspfmASCRSLILGGDSSEDgHYFRGYLGTLVIWSTALSQTHLQ 440
Cdd:pfam13385   79 GQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPP----GTGGPLYIGRSPGGD-DYFNGLIDEVRIYDRALSAAEIA 151
LamGL smart00560
LamG-like jellyroll fold domain;
287-437 5.22e-19

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 84.78  E-value: 5.22e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815    287 AFTVEAWVRPEGGQSNPAIIagvfdncshtvndKGWALGIRSGKDKgwrDARFFFSLRTDRmKKATIVTGHSRYQPGMWT 366
Cdd:smart00560    2 SFTLEAWVKLESAGGSQPII-------------TGAAVAQPTISEK---ALTFFLRAKSVQ-GWQTARTGATADWIGVWV 64

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568910815    367 HVAATYDGQHT--ALYVDGTRVASSRDQFGPLNSPFMASCRSLiLGGDSsedGHYFRGYLGTLVIWSTALSQT 437
Cdd:smart00560   65 HLAGVYDGGAGklSLYVNGVEVATSETQPSPSSGNLPQGGRIL-LGGAG---GENFSGRLDEVRVYNRALTAR 133
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 1113-1152 1.23e-12

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 63.55  E-value: 1.23e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568910815  1113 GPYCGDGKVERsiGEMCDDGDLLNGDGCSRACELEEGFNC 1152
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
Peptidase_M43 pfam05572
Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a ...
 680-832 1.57e-06

Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a metallo-protease belonging to Merops family M43. It cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II. Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system.


Pssm-ID: 368506  Cd Length: 152  Bit Score: 49.53  E-value: 1.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815   680 NSTHFLNVYFASSVREDL---AGSATWPWDKEALSHLGGVVLNPTY-YGMLGHTN---IMIHEVGHVLGLYHVFKGVSER 752
Cdd:pfam05572   13 DNEKYMNVYIQNDLADGLtnnSGVAWYPDSGMSADGTARVVFNGAYlAADPTSTNfssTLTHEFGHFLGLIHTFEGGCER 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815   753 escddpcretvpsmETGDLCADT-APTPKSKLCRDPEPANdtCGftlfpGAPFN--NYMSYTDdeCTDNFTPNQVARMHC 829
Cdd:pfam05572   93 --------------GEGDKVPDTpSYTGGEVSLRNKDLFN--CN-----GEPINsqNQMDYNG--CYAMFTQDQVDRMVE 149


                   ...
gi 568910815   830 YLD 832
Cdd:pfam05572  150 VLA 152
Sushi pfam00084
Sushi repeat (SCR repeat);
1523-1586 1.69e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.03  E-value: 1.69e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568910815  1523 CEAPPVIPNANLllpHFLEGNHDVGTICKYECKPGYYvkeTSGSqgknkfLKIQCLDDGSWEQG 1586
Cdd:pfam00084    1 CPPPPDIPNGKV---SATKNEYNYGASVSYECDPGYR---LVGS------PTITCQEDGTWSPP 52
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1523-1583 2.17e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.61  E-value: 2.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568910815 1523 CEAPPVIPNANLllpHFLEGNHDVGTICKYECKPGYYVKETSgsqgknkflKIQCLDDGSW 1583
Cdd:cd00033     1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSS---------TITCTENGGW 49
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1720-1756 2.50e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 42.70  E-value: 2.50e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 568910815   1720 PDPSLVHC-IQSCEPFQADGWCDTINNRAYCNYDGGDC 1756
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
MJ1470 COG5306
Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type ...
 264-388 3.87e-05

Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 444105 [Multi-domain]  Cd Length: 529  Bit Score: 48.36  E-value: 3.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815  264 LYFTGKRERLLLRPEVLAEIPREAFTVEAWVRPEGGQSNPAIiagvfdncshtVNDKGWALGIRSGKDkgwrdarfFFSL 343
Cdd:COG5306   175 AQFDGTSPLVVPASPSLALDAGGGFTFSAWIKPAQLDGNAVL-----------YSRRDGANGLDNGAP--------FVEV 235

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 568910815  344 RTDrmkKATIVTGHSRYQPGMWTHVAATYDGQHTALYVDGTRVAS 388
Cdd:COG5306   236 GGA---GGTRSAAGAPLAAGTWHHLAVVADAGKVTLYVNGVAAGS 277
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1523-1583 7.77e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 42.13  E-value: 7.77e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568910815   1523 CEAPPVIPNANLLLPHfleGNHDVGTICKYECKPGYYVKETSgsqgknkflKIQCLDDGSW 1583
Cdd:smart00032    1 CPPPPDIENGTVTSSS---GTYSYGDTVTYSCDPGYTLIGSS---------TITCLENGTW 49
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 586-613 2.54e-04

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 40.00  E-value: 2.54e-04
                            10        20
                    ....*....|....*....|....*...
gi 568910815    586 NCEpSKIGNDHCDPECEHPLTGFDGGDC 613
Cdd:smart00004   12 QCW-DKFGDGVCDEECNNAECLWDGGDC 38
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
 685-744 8.73e-04

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 42.40  E-value: 8.73e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568910815  685 LNVYFASSVREDLAGSATWPWDKEALSHLGGVVLNPTYYGMLG-----HTNIMIHEVGHVLGLYH 744
Cdd:cd04277    65 IRFGNSSDPDGNTAGYAYYPGSGSGTAYGGDIWFNSSYDTNSDspgsyGYQTIIHEIGHALGLEH 129
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 697-750 1.19e-03

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 41.71  E-value: 1.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568910815  697 LAGSATWPWDKEAlsHLGGVVLNPTYYGMLGH--TNIMIHEVGHVLGLYHVFKGVS 750
Cdd:cd04268    63 YGPSQVDPLTGEI--LLARVYLYSSFVEYSGArlRNTAEHELGHALGLRHNFAASD 116
LamG smart00282
Laminin G domain;
349-431 1.81e-03

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 40.40  E-value: 1.81e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815    349 KKATIVTGHSRYQPGMWTHVAATYDGQHTALYVDGTRVASSRDqfgPLNSPFMASCRSLILGG-------DSSEDGHYFR 421
Cdd:smart00282   45 GPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGGNRVSGES---PGGLTILNLDGPLYLGGlpedlklPPLPVTPGFR 121

                            90
                    ....*....|
gi 568910815    422 GYLGTLVIWS 431
Cdd:smart00282  122 GCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 323-430 8.21e-03

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 38.94  E-value: 8.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568910815  323 ALGIRSGKdkgwrdarffFSLRTDRMKKATIVTGHSRYQPGMWTHVAATYDGQHTALYVDGTRVASSRDqfgPLNSPFMA 402
Cdd:cd00110    50 ALELEDGR----------LVLRYDLGSGSLVLSSKTPLNDGQWHSVSVERNGRSVTLSVDGERVVESGS---PGGSALLN 116

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 568910815  403 SCRSLILGG--DSSED-----GHYFRGYLGTLVIW 430
Cdd:cd00110   117 LDGPLYLGGlpEDLKSpglpvSPGFVGCIRDLKVN 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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