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Conserved domains on  [gi|568912259|ref|XP_006497468|]
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ras suppressor protein 1 isoform X1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-185 1.98e-33

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.43  E-value: 1.98e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  36 LSVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLNehSLPGNFFY 115
Cdd:COG4886  103 LSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLT--DLPEELGN 180

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259 116 LTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLpPELGNL 185
Cdd:COG4886  181 LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL-PELGNL 249
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-185 1.98e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.43  E-value: 1.98e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  36 LSVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLNehSLPGNFFY 115
Cdd:COG4886  103 LSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLT--DLPEELGN 180

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259 116 LTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLpPELGNL 185
Cdd:COG4886  181 LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL-PELGNL 249
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 20-185 1.89e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.80  E-value: 1.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  20 VDMSDRGISSmldvnglSVPPNVAELKNLEVLNFFNNQIE-ELPTQISSL-QKLKHLNLGMNRLN-TLPRGFgsLPALEV 96
Cdd:PLN00113  74 IDLSGKNISG-------KISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTgSIPRGS--IPNLET 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  97 LDLTyNNLNEHSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI---------------------- 153
Cdd:PLN00113 145 LDLS-NNMLSGEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynn 223

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 568912259 154 ---SLPKEIGELTQLKELHIQGNRLT-VLPPELGNL 185
Cdd:PLN00113 224 lsgEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNL 259
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 22-189 8.97e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 8.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  22 MSDRGISSMldvnglsvpPNVAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTLPrGFGSLPALEVLDLTY 101
Cdd:cd21340    9 LNDKNITKI---------DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259 102 NNLNEHSlpgNFFYLTTLRALYLSDNDfeiLPPDiGKLTK-----------LQILSLRDNDLISLpKEIGELTQLKELHI 170
Cdd:cd21340   78 NRISVVE---GLENLTNLEELHIENQR---LPPG-EKLTFdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDA 149

                        170       180
                 ....*....|....*....|....*...
gi 568912259 171 QGNRLTVLP---------PELGNLDLTG 189
Cdd:cd21340  150 SNNQISDLEelldllsswPSLRELDLTG 177
LRR_8 pfam13855
Leucine rich repeat;
69-129 3.16e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 3.16e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568912259   69 QKLKHLNLGMNRLNTLPRG-FGSLPALEVLDLTYNNLNeHSLPGNFFYLTTLRALYLSDNDF 129
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-185 1.98e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 125.43  E-value: 1.98e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  36 LSVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLNehSLPGNFFY 115
Cdd:COG4886  103 LSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLT--DLPEELGN 180

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259 116 LTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLpPELGNL 185
Cdd:COG4886  181 LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL-PELGNL 249
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-185 1.05e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.02  E-value: 1.05e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  27 ISSMLDVNGLSVPPNVAELKNLEVLNFFNNQieelptQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLNe 106
Cdd:COG4886   77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLT- 149

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568912259 107 hSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 185
Cdd:COG4886  150 -DLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANL 227
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-185 1.09e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 1.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  32 DVNGLSVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRlntlprGFGSLPALEVLDLTYNNLNehSLPG 111
Cdd:COG4886   59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLT--DLPE 130

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568912259 112 NFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 185
Cdd:COG4886  131 ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNL 204
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-185 2.10e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 2.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  36 LSVPPNVAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNlnehslpgNFFY 115
Cdd:COG4886   40 LSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--------ELSN 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259 116 LTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 185
Cdd:COG4886  112 LTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNL 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 20-185 1.89e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.80  E-value: 1.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  20 VDMSDRGISSmldvnglSVPPNVAELKNLEVLNFFNNQIE-ELPTQISSL-QKLKHLNLGMNRLN-TLPRGFgsLPALEV 96
Cdd:PLN00113  74 IDLSGKNISG-------KISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTgSIPRGS--IPNLET 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  97 LDLTyNNLNEHSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI---------------------- 153
Cdd:PLN00113 145 LDLS-NNMLSGEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynn 223

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 568912259 154 ---SLPKEIGELTQLKELHIQGNRLT-VLPPELGNL 185
Cdd:PLN00113 224 lsgEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNL 259
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-183 5.20e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.64  E-value: 5.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  38 VPPNVAELKNLEVLNF-FNNQIEELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLtYNNLNEHSLPGNFFY 115
Cdd:PLN00113 204 IPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFL-YQNKLSGPIPPSIFS 282

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568912259 116 LTTLRALYLSDNDF--EIlPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT-VLPPELG 183
Cdd:PLN00113 283 LQKLISLDLSDNSLsgEI-PELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLG 353
PLN03150 PLN03150
hypothetical protein; Provisional
 61-127 4.24e-11

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 62.53  E-value: 4.24e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568912259  61 LPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLNeHSLPGNFFYLTTLRALYLSDN 127
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFN-GSIPESLGQLTSLRILNLNGN 500
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 27-176 2.21e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 2.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  27 ISSMLDVNGLS--VPPNVAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYN 102
Cdd:PLN00113 287 ISLDLSDNSLSgeIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTN 366

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568912259 103 NLNeHSLPGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT 176
Cdd:PLN00113 367 NLT-GEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQ 441
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
27-200 2.68e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.48  E-value: 2.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  27 ISSMLDVNGL-SVPPNVAelKNLEVLNFFNNQIEELPTQISSlqKLKHLNLGMNRLNTLPRGFGSlpALEVLDLTYNNLN 105
Cdd:PRK15370 202 TTLILDNNELkSLPENLQ--GNIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERLPS--ALQSLDLFHNKIS 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259 106 --EHSLPGNFFYL-------TTLRA--------LYLSDNDFEILPPDIGklTKLQILSLRDNDLISLPKEIGelTQLKEL 168
Cdd:PRK15370 276 clPENLPEELRYLsvydnsiRTLPAhlpsgithLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVL 351

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 568912259 169 HIQGNRLTV----LPPELGNLDLTGQKQVFKAENNP 200
Cdd:PRK15370 352 DVSKNQITVlpetLPPTITTLDVSRNALTNLPENLP 387
PLN03150 PLN03150
hypothetical protein; Provisional
 41-200 4.31e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.44  E-value: 4.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  41 NVAELKNLEVLNFFNNQIEELPTQISSLQKLKH-----LNLGMNRLNTLPR---------GFGSLPALEVLDLTynNLNE 106
Cdd:PLN03150 350 THAIINAIEVFEIITAESKTLLEEVSALQTLKSslglpLRFGWNGDPCVPQqhpwsgadcQFDSTKGKWFIDGL--GLDN 427

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259 107 HSL----PGNFFYLTTLRALYLSDNDFE-ILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT-VLP 179
Cdd:PLN03150 428 QGLrgfiPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVP 507

                        170       180
                 ....*....|....*....|.
gi 568912259 180 PELGNLDLTGQKqvFKAENNP 200
Cdd:PLN03150 508 AALGGRLLHRAS--FNFTDNA 526
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 22-189 8.97e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 8.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  22 MSDRGISSMldvnglsvpPNVAELKNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNTLPrGFGSLPALEVLDLTY 101
Cdd:cd21340    9 LNDKNITKI---------DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259 102 NNLNEHSlpgNFFYLTTLRALYLSDNDfeiLPPDiGKLTK-----------LQILSLRDNDLISLpKEIGELTQLKELHI 170
Cdd:cd21340   78 NRISVVE---GLENLTNLEELHIENQR---LPPG-EKLTFdprslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDA 149

                        170       180
                 ....*....|....*....|....*...
gi 568912259 171 QGNRLTVLP---------PELGNLDLTG 189
Cdd:cd21340  150 SNNQISDLEelldllsswPSLRELDLTG 177
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 31-191 1.48e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 1.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  31 LDVNGLS--VPPNVAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLnE 106
Cdd:PLN00113 363 LSTNNLTgeIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL-Q 441

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259 107 HSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI-SLPKEIGELTQLKELHIQGNRLT-VLPPELG- 183
Cdd:PLN00113 442 GRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSs 521

                        170
                 ....*....|...
gi 568912259 184 -----NLDLTGQK 191
Cdd:PLN00113 522 ckklvSLDLSHNQ 534
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-183 6.57e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.31  E-value: 6.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  37 SVPPNVAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLPRGFGSLPALEVLDLTYNNLNeHSLPGNFF 114
Cdd:PLN00113 251 PIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFT-GKIPVALT 329

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568912259 115 YLTTLRALYLSDNDF--EIlPPDIGKLTKLQILSLRDNDLIS-LPKEIGELTQLKELHIQGNRL-TVLPPELG 183
Cdd:PLN00113 330 SLPRLQVLQLWSNKFsgEI-PKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLeGEIPKSLG 401
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
32-179 1.65e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 51.70  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  32 DVNGLSVPPNVAELKNLEV-----------------LNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGF------ 88
Cdd:PRK15387 231 DNNLTSLPALPPELRTLEVsgnqltslpvlppglleLSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLqelsvs 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  89 ----GSLPAL--EVLDLTYNNLNEHSLPGnffYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGEL 162
Cdd:PRK15387 311 dnqlASLPALpsELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKEL 387

                        170       180       190
                 ....*....|....*....|....*....|.
gi 568912259 163 --------------TQLKELHIQGNRLTVLP 179
Cdd:PRK15387 388 ivsgnrltslpvlpSELKELMVSGNRLTSLP 418
LRR_8 pfam13855
Leucine rich repeat;
69-129 3.16e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 3.16e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568912259   69 QKLKHLNLGMNRLNTLPRG-FGSLPALEVLDLTYNNLNeHSLPGNFFYLTTLRALYLSDNDF 129
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 8-153 6.05e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 6.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259   8 LVEESREKNQPEVDMSDRGISSMldvnglsVPPNVAELKNLEVLNFFNNQIE-ELPTQISSLQKLKHLNLGMNRLN-TLP 85
Cdd:PLN00113 468 LPDSFGSKRLENLDLSRNQFSGA-------VPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIP 540

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568912259  86 RGFGSLPALEVLDLTYNNLNeHSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI 153
Cdd:PLN00113 541 ASFSEMPVLSQLDLSQNQLS-GEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAGNIDL 607
LRR_8 pfam13855
Leucine rich repeat;
47-104 7.01e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 7.01e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259   47 NLEVLNFFNNQIEEL-PTQISSLQKLKHLNLGMNRLNTL-PRGFGSLPALEVLDLTYNNL 104
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
31-207 3.91e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 3.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  31 LDVNGLSVPPNVAELKNLEVLNFFNNQIEELPTqISSLQKLKHLNLGMNRLNTLP-RGFGSLPALEVLDLTYNNLNEHSL 109
Cdd:COG4886  235 LSNNQLTDLPELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLEL 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259 110 PGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTG 189
Cdd:COG4886  314 LILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393

                        170
                 ....*....|....*...
gi 568912259 190 QKQVFKAENNPWVTPIAD 207
Cdd:COG4886  394 LTTTAGVLLLTLALLDAV 411
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 63-176 6.06e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 6.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  63 TQISSLQKLKHLN--LGMNRLNTLPRGFGSL-PALEVLDLTYNNLNEHS---LPGNFFYLTTLRALYLSDND-----FEI 131
Cdd:cd00116  105 LRSSSLQELKLNNngLGDRGLRLLAKGLKDLpPALEKLVLGRNRLEGASceaLAKALRANRDLKELNLANNGigdagIRA 184

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568912259 132 LPPDIGKLTKLQILSLRDNDL-----ISLPKEIGELTQLKELHIQGNRLT 176
Cdd:cd00116  185 LAEGLKANCNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLT 234
LRR_8 pfam13855
Leucine rich repeat;
92-152 7.82e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 7.82e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568912259   92 PALEVLDLTYNNLneHSL-PGNFFYLTTLRALYLSDNDFEILPPD-IGKLTKLQILSLRDNDL 152
Cdd:pfam13855   1 PNLRSLDLSNNRL--TSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
48-176 7.50e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.53  E-value: 7.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259  48 LEVLNFFNNQIEELPTQISSLQKLKHLNlgmNRLNTLPrgfgSLPA-LEVLDLTYNNLNehSLPgnfFYLTTLRALYLSD 126
Cdd:PRK15387 344 LQELSVSDNQLASLPTLPSELYKLWAYN---NRLTSLP----ALPSgLKELIVSGNRLT--SLP---VLPSELKELMVSG 411

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568912259 127 NDFEILP--PdigklTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLT 176
Cdd:PRK15387 412 NRLTSLPmlP-----SGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLS 458
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 2-193 6.97e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 37.55  E-value: 6.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259    2 SKSLKKLVEESREKNQPEVDMSDrgISSMLDVnglsvPPNVAELKNLEVLNF-FNNQIEELPTQISsLQKLKHLNL-GMN 79
Cdd:PLN03210  644 SKNLKEIPDLSMATNLETLKLSD--CSSLVEL-----PSSIQYLNKLEDLDMsRCENLEILPTGIN-LKSLYRLNLsGCS 715

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259   80 RLNTLPrgfgSLPA-LEVLDLTYNNLNEhsLPGNFfYLTTLRALYLSDNDFEILPPDIGKLTKLQI--------LSLRDN 150
Cdd:PLN03210  716 RLKSFP----DISTnISWLDLDETAIEE--FPSNL-RLENLDELILCEMKSEKLWERVQPLTPLMTmlspsltrLFLSDI 788

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 568912259  151 -DLISLPKEIGELTQLKELHIQGNR-LTVLP-----PELGNLDLTGQKQV 193
Cdd:PLN03210  789 pSLVELPSSIQNLHKLEHLEIENCInLETLPtginlESLESLDLSGCSRL 838
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 46-83 8.62e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.37  E-value: 8.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568912259   46 KNLEVLNFFNNQIEELPtQISSLQKLKHLNLGMNRLNT 83
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNNKIT 37
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 48-165 8.93e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 37.16  E-value: 8.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568912259   48 LEVLNFFNNQ-IEELPTQISSLQKLKHLNLgMN--RLNTLPRGFgSLPALEVLDL-------TYNNLNehslpgnffylT 117
Cdd:PLN03210  780 LTRLFLSDIPsLVELPSSIQNLHKLEHLEI-ENciNLETLPTGI-NLESLESLDLsgcsrlrTFPDIS-----------T 846

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 568912259  118 TLRALYLSDNDFEILPPDIGKLTKLQILSLRD-NDLISLPKEIGELTQL 165
Cdd:PLN03210  847 NISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHL 895
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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