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Conserved domains on  [gi|568913237|ref|XP_006497889|]
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surfeit locus protein 1 isoform X4 [Mus musculus]

Protein Classification

SURF1 family protein( domain architecture ID 10160031)

SURF1 family protein similar to yeast cytochrome oxidase assembly protein SHY1, which is required for efficient assembly of cytochrome c oxidase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SURF1 cd06662
SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the ...
 113-208 1.06e-25

SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.


:

Pssm-ID: 119401  Cd Length: 202  Bit Score: 99.34  E-value: 1.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913237 113 FGLGTWQVQRRKWKLKLIAELESRVMAEPIPLPAD-PMELKNLEYRPVKVRGHFDHSKELYIMPRTMvdpvreardAGRl 191
Cdd:cd06662    2 VGLGFWQLQRAEWKEALIARIEARLAAPPVPLPELlAPPLEDLEYRRVTVTGTFLPEKEVLLDNRTR---------DGR- 71

                         90
                 ....*....|....*..
gi 568913237 192 ssteSGAHVVTPFHCSD 208
Cdd:cd06662   72 ----PGYEVLTPFRLDD 84
 
Name Accession Description Interval E-value
SURF1 cd06662
SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the ...
 113-208 1.06e-25

SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.


Pssm-ID: 119401  Cd Length: 202  Bit Score: 99.34  E-value: 1.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913237 113 FGLGTWQVQRRKWKLKLIAELESRVMAEPIPLPAD-PMELKNLEYRPVKVRGHFDHSKELYIMPRTMvdpvreardAGRl 191
Cdd:cd06662    2 VGLGFWQLQRAEWKEALIARIEARLAAPPVPLPELlAPPLEDLEYRRVTVTGTFLPEKEVLLDNRTR---------DGR- 71

                         90
                 ....*....|....*..
gi 568913237 192 ssteSGAHVVTPFHCSD 208
Cdd:cd06662   72 ----PGYEVLTPFRLDD 84
SURF1 pfam02104
SURF1 family;
106-211 8.72e-25

SURF1 family;


Pssm-ID: 460447  Cd Length: 195  Bit Score: 96.70  E-value: 8.72e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913237  106 LLIPATAFGLGTWQVQRRKWKLKLIAELESRVMAEPIPLPADPME--LKNLEYRPVKVRGHFDhSKELYIMPRtmvdpVR 183
Cdd:pfam02104   1 LLPAAVFFALGTWQLQRLEWKEALIAALEARVAAPPLPLPLPPDDavPADLEYRRVTVTGRFD-DKEVLVGNR-----VG 74

                          90       100
                  ....*....|....*....|....*...
gi 568913237  184 EARdagrlsstesGAHVVTPFHCSDLGQ 211
Cdd:pfam02104  75 RPR----------GYHVLTPLRLTDDGR 92
Shy1 COG3346
Cytochrome oxidase assembly protein ShyY1 [Posttranslational modification, protein turnover, ...
 105-208 3.44e-18

Cytochrome oxidase assembly protein ShyY1 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442575  Cd Length: 245  Bit Score: 80.36  E-value: 3.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913237 105 LLLIPATAfGLGTWQVQRRKWKLKLIAELESRVMAEPIPLPA----DPMELKNLEYRPVKVRGHFDHSKELYIMPRTMvd 180
Cdd:COG3346   17 LVLAAVLV-ALGFWQLQRAEEKEALIARIEARLAAPPVPLPEllawPAAFPADDEYRRVTVTGRYLPDHQVLLDNRTL-- 93

                         90       100
                 ....*....|....*....|....*...
gi 568913237 181 pvreardAGRlssteSGAHVVTPFHCSD 208
Cdd:COG3346   94 -------DGR-----PGYEVLTPLRLDD 109
 
Name Accession Description Interval E-value
SURF1 cd06662
SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the ...
 113-208 1.06e-25

SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.


Pssm-ID: 119401  Cd Length: 202  Bit Score: 99.34  E-value: 1.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913237 113 FGLGTWQVQRRKWKLKLIAELESRVMAEPIPLPAD-PMELKNLEYRPVKVRGHFDHSKELYIMPRTMvdpvreardAGRl 191
Cdd:cd06662    2 VGLGFWQLQRAEWKEALIARIEARLAAPPVPLPELlAPPLEDLEYRRVTVTGTFLPEKEVLLDNRTR---------DGR- 71

                         90
                 ....*....|....*..
gi 568913237 192 ssteSGAHVVTPFHCSD 208
Cdd:cd06662   72 ----PGYEVLTPFRLDD 84
SURF1 pfam02104
SURF1 family;
106-211 8.72e-25

SURF1 family;


Pssm-ID: 460447  Cd Length: 195  Bit Score: 96.70  E-value: 8.72e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913237  106 LLIPATAFGLGTWQVQRRKWKLKLIAELESRVMAEPIPLPADPME--LKNLEYRPVKVRGHFDhSKELYIMPRtmvdpVR 183
Cdd:pfam02104   1 LLPAAVFFALGTWQLQRLEWKEALIAALEARVAAPPLPLPLPPDDavPADLEYRRVTVTGRFD-DKEVLVGNR-----VG 74

                          90       100
                  ....*....|....*....|....*...
gi 568913237  184 EARdagrlsstesGAHVVTPFHCSDLGQ 211
Cdd:pfam02104  75 RPR----------GYHVLTPLRLTDDGR 92
Shy1 COG3346
Cytochrome oxidase assembly protein ShyY1 [Posttranslational modification, protein turnover, ...
 105-208 3.44e-18

Cytochrome oxidase assembly protein ShyY1 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442575  Cd Length: 245  Bit Score: 80.36  E-value: 3.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568913237 105 LLLIPATAfGLGTWQVQRRKWKLKLIAELESRVMAEPIPLPA----DPMELKNLEYRPVKVRGHFDHSKELYIMPRTMvd 180
Cdd:COG3346   17 LVLAAVLV-ALGFWQLQRAEEKEALIARIEARLAAPPVPLPEllawPAAFPADDEYRRVTVTGRYLPDHQVLLDNRTL-- 93

                         90       100
                 ....*....|....*....|....*...
gi 568913237 181 pvreardAGRlssteSGAHVVTPFHCSD 208
Cdd:COG3346   94 -------DGR-----PGYEVLTPLRLDD 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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