ly6/PLAUR domain-containing protein 6B isoform X1 [Mus musculus]
UPAR_LY6_2 domain-containing protein( domain architecture ID 11246579)
UPAR_LY6_2 domain-containing protein
List of domain hits
Name | Accession | Description | Interval | E-value | |||
UPAR_LY6_2 | pfam16975 | Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic ... |
58-163 | 5.94e-57 | |||
Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic proteins expressed in neurons. It modulates nicotinic acetylcholine receptors by selectively increasing Ca2+-influx through this ion channel. The family carries an LU protein domain - about 80 amino acids long characterized by a conserved pattern of 10 cysteine residues. The family is a positive feedback regulator of Wnt/beta-catenin signalling, eg for patterning of the mesoderm and neuroectoderm in zebrafish gastrulation, where Lypd6 is GPI-anchored to the plasma-membrane and interacts with the Wnt receptor Frizzled8 and the co-receptor Lrp6. : Pssm-ID: 435685 Cd Length: 106 Bit Score: 174.84 E-value: 5.94e-57
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Name | Accession | Description | Interval | E-value | |||
UPAR_LY6_2 | pfam16975 | Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic ... |
58-163 | 5.94e-57 | |||
Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic proteins expressed in neurons. It modulates nicotinic acetylcholine receptors by selectively increasing Ca2+-influx through this ion channel. The family carries an LU protein domain - about 80 amino acids long characterized by a conserved pattern of 10 cysteine residues. The family is a positive feedback regulator of Wnt/beta-catenin signalling, eg for patterning of the mesoderm and neuroectoderm in zebrafish gastrulation, where Lypd6 is GPI-anchored to the plasma-membrane and interacts with the Wnt receptor Frizzled8 and the co-receptor Lrp6. Pssm-ID: 435685 Cd Length: 106 Bit Score: 174.84 E-value: 5.94e-57
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LU | smart00134 | Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ... |
67-151 | 6.31e-05 | |||
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins. Pssm-ID: 214530 Cd Length: 85 Bit Score: 39.83 E-value: 6.31e-05
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Name | Accession | Description | Interval | E-value | |||
UPAR_LY6_2 | pfam16975 | Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic ... |
58-163 | 5.94e-57 | |||
Ly6/PLAUR domain-containing protein 6, Lypd6; UPAR_LY6_2 is a family of higher eukaryotic proteins expressed in neurons. It modulates nicotinic acetylcholine receptors by selectively increasing Ca2+-influx through this ion channel. The family carries an LU protein domain - about 80 amino acids long characterized by a conserved pattern of 10 cysteine residues. The family is a positive feedback regulator of Wnt/beta-catenin signalling, eg for patterning of the mesoderm and neuroectoderm in zebrafish gastrulation, where Lypd6 is GPI-anchored to the plasma-membrane and interacts with the Wnt receptor Frizzled8 and the co-receptor Lrp6. Pssm-ID: 435685 Cd Length: 106 Bit Score: 174.84 E-value: 5.94e-57
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LU | smart00134 | Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ... |
67-151 | 6.31e-05 | |||
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins. Pssm-ID: 214530 Cd Length: 85 Bit Score: 39.83 E-value: 6.31e-05
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Blast search parameters | ||||
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