NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568916308|ref|XP_006499235|]
View 

plakophilin-4 isoform X5 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 557-596 5.37e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.84  E-value: 5.37e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568916308   557 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 596
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 863-898 4.31e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.31e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 568916308    863 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 898
Cdd:smart00185    5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 601-642 4.35e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.35e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568916308    601 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 642
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
DUF5585 super family cl39316
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 71-357 6.81e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


The actual alignment was detected with superfamily member pfam17823:

Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 46.88  E-value: 6.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308    71 LGAESPSIASTSSTEKSFPWRSTDVPNPgVSKPRVSDTIHPNNYLIRTEpeqgtlYSPEQTSLHE---SEGSLGNSRSST 147
Cdd:pfam17823   42 ASGDAVPRADNKSSEQ*NFCAATAAPAP-VTLTKGTSAAHLNSTEVTAE------HTPHGTDLSEpatREGAADGAASRA 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308   148 QMNSYSDSGYQEAGSFHNSQTVNKADSRQHPFTGSTSNHVVRTSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVTSt 227
Cdd:pfam17823  115 LAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASS- 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308   228 gvSPSRGSLRTSlgsgfgsPSVTDSRPLNPSAYSSSTlPAqrAASPYSQRPASPTAVRRVGSVTSRQTSNPNGPVPQY-Q 306
Cdd:pfam17823  194 --APTTAASSAP-------ATLTPARGISTAATATGH-PA--AGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAaG 261

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568916308   307 TTTRVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGPSLQRTV 357
Cdd:pfam17823  262 TVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVST 312
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 846-967 1.22e-03

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.17  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308  846 GSLQNLSA---GNWkfAAYIRAAvrkekGLPILVELLRMDNDRVVSSVATALRNMAL---DVRNKeLIGKYAMRDLVNRL 919
Cdd:PLN03200  169 GALRNLCGstdGFW--SATLEAG-----GVDILVKLLSSGNSDAQANAASLLARLMMafeSSISK-VLDAGAVKQLLKLL 240

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568916308  920 PGGNGPSILsdetvAAICCALHEVTSKNMENAKALADSGGIEKLVNIT 967
Cdd:PLN03200  241 GQGNEVSVR-----AEAAGALEALSSQSKEAKQAIADAGGIPALINAT 283
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 947-991 3.63e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 3.63e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568916308    947 NMENAKALADSGGIEKLVNITKgrgdRSSLKVVKAAAQVLNTLWQ 991
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLSS 41
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 557-596 5.37e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.84  E-value: 5.37e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568916308   557 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 596
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 557-597 7.77e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.43  E-value: 7.77e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568916308    557 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLVF 597
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 863-898 4.31e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.31e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 568916308    863 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 898
Cdd:smart00185    5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 601-642 4.35e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.35e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568916308    601 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 642
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 601-642 2.14e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.52  E-value: 2.14e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568916308   601 TDENKIAMKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSS 642
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 71-357 6.81e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 46.88  E-value: 6.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308    71 LGAESPSIASTSSTEKSFPWRSTDVPNPgVSKPRVSDTIHPNNYLIRTEpeqgtlYSPEQTSLHE---SEGSLGNSRSST 147
Cdd:pfam17823   42 ASGDAVPRADNKSSEQ*NFCAATAAPAP-VTLTKGTSAAHLNSTEVTAE------HTPHGTDLSEpatREGAADGAASRA 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308   148 QMNSYSDSGYQEAGSFHNSQTVNKADSRQHPFTGSTSNHVVRTSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVTSt 227
Cdd:pfam17823  115 LAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASS- 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308   228 gvSPSRGSLRTSlgsgfgsPSVTDSRPLNPSAYSSSTlPAqrAASPYSQRPASPTAVRRVGSVTSRQTSNPNGPVPQY-Q 306
Cdd:pfam17823  194 --APTTAASSAP-------ATLTPARGISTAATATGH-PA--AGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAaG 261

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568916308   307 TTTRVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGPSLQRTV 357
Cdd:pfam17823  262 TVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVST 312
HEAT COG1413
HEAT repeat [General function prediction only];
524-646 1.98e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.69  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308  524 RDPE-LPEVIHMLQHQFPSVQANAAAYLQHLcfGDNKVkmevyrlggIKHLVDLLDHRVLEVQKNACGALRNLvfgkstd 602
Cdd:COG1413    13 GDPAaVPALIAALADEDPDVRAAAARALGRL--GDPRA---------VPALLEALKDPDPEVRAAAAEALGRI------- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 568916308  603 enkiamKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSSCDAV 646
Cdd:COG1413    75 ------GDPEAVPALIAAL-KDEDPEVRRAAAEALGRLGDPAAV 111
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 863-898 2.55e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 2.55e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568916308   863 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 898
Cdd:pfam00514    5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 846-967 1.22e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.17  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308  846 GSLQNLSA---GNWkfAAYIRAAvrkekGLPILVELLRMDNDRVVSSVATALRNMAL---DVRNKeLIGKYAMRDLVNRL 919
Cdd:PLN03200  169 GALRNLCGstdGFW--SATLEAG-----GVDILVKLLSSGNSDAQANAASLLARLMMafeSSISK-VLDAGAVKQLLKLL 240

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568916308  920 PGGNGPSILsdetvAAICCALHEVTSKNMENAKALADSGGIEKLVNIT 967
Cdd:PLN03200  241 GQGNEVSVR-----AEAAGALEALSSQSKEAKQAIADAGGIPALINAT 283
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 220-377 1.57e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 42.61  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308  220 SPSYVTSTGVSPSRGSLRTSlgsgfgspSVTDSRPLNPSAYSSSTLPA----------QRAASPY----------SQRPA 279
Cdd:PLN03209  385 SPIPTPPSSSPASSKSVDAV--------AKPAEPDVVPSPGSASNVPEvepaqveakkTRPLSPYaryedlkpptSPSPT 456

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308  280 SPTAVRRVGSVTSRQTSNPNGPVPQYQTTT--------RVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGP 351
Cdd:PLN03209  457 APTGVSPSVSSTSSVPAVPDTAPATAATDAaapppanmRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSA 536

                         170       180       190
                  ....*....|....*....|....*....|.
gi 568916308  352 SLQRTVHDMDQFGQQQ-----YDIYERMVPP 377
Cdd:PLN03209  537 PPTALADEQHHAQPKPrplspYTMYEDLKPP 567
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 947-991 3.63e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 3.63e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568916308    947 NMENAKALADSGGIEKLVNITKgrgdRSSLKVVKAAAQVLNTLWQ 991
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 528-642 6.35e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.86  E-value: 6.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308  528 LPEVIHMLQHQFPSVQANAAAYLQHLCfGDNKVKMEVYrLGG-IKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDEnkI 606
Cdd:PLN03200   60 MPLLVSLLRSGTLGAKVNAAAVLGVLC-KEEDLRVKVL-LGGcIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDH--V 135

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 568916308  607 AMK---NVGGIPALLRLL--RKSIDAEVRELVTGVLWNLSS 642
Cdd:PLN03200  136 GSKifsTEGVVPSLWDQLqpGNKQDKVVEGLLTGALRNLCG 176
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 557-596 5.37e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.84  E-value: 5.37e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568916308   557 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 596
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 557-597 7.77e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.43  E-value: 7.77e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 568916308    557 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLVF 597
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 863-898 4.31e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.31e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 568916308    863 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 898
Cdd:smart00185    5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 601-642 4.35e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.35e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 568916308    601 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 642
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 601-642 2.14e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.52  E-value: 2.14e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568916308   601 TDENKIAMKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSS 642
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 71-357 6.81e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 46.88  E-value: 6.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308    71 LGAESPSIASTSSTEKSFPWRSTDVPNPgVSKPRVSDTIHPNNYLIRTEpeqgtlYSPEQTSLHE---SEGSLGNSRSST 147
Cdd:pfam17823   42 ASGDAVPRADNKSSEQ*NFCAATAAPAP-VTLTKGTSAAHLNSTEVTAE------HTPHGTDLSEpatREGAADGAASRA 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308   148 QMNSYSDSGYQEAGSFHNSQTVNKADSRQHPFTGSTSNHVVRTSRAEGQTLVQPSVANRAMRRVSSVPSRAQSPSYVTSt 227
Cdd:pfam17823  115 LAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASS- 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308   228 gvSPSRGSLRTSlgsgfgsPSVTDSRPLNPSAYSSSTlPAqrAASPYSQRPASPTAVRRVGSVTSRQTSNPNGPVPQY-Q 306
Cdd:pfam17823  194 --APTTAASSAP-------ATLTPARGISTAATATGH-PA--AGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAaG 261

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568916308   307 TTTRVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGPSLQRTV 357
Cdd:pfam17823  262 TVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVST 312
HEAT COG1413
HEAT repeat [General function prediction only];
524-646 1.98e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.69  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308  524 RDPE-LPEVIHMLQHQFPSVQANAAAYLQHLcfGDNKVkmevyrlggIKHLVDLLDHRVLEVQKNACGALRNLvfgkstd 602
Cdd:COG1413    13 GDPAaVPALIAALADEDPDVRAAAARALGRL--GDPRA---------VPALLEALKDPDPEVRAAAAEALGRI------- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 568916308  603 enkiamKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSSCDAV 646
Cdd:COG1413    75 ------GDPEAVPALIAAL-KDEDPEVRRAAAEALGRLGDPAAV 111
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 72-382 2.23e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.53  E-value: 2.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308    72 GAESPSIASTSSTE-------KSFPWRSTDVPNPGVSKPR-----VSDTIHPNNYLIRTEPEQGtLYSPEQTSlhESEGS 139
Cdd:pfam03154   43 GRNSPSAASTSSNDskaesmkKSSKKIKEEAPSPLKSAKRqrekgASDTEEPERATAKKSKTQE-ISRPNSPS--EGEGE 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308   140 LGNSRsstqmnSYSDSGYQEAGSFHNSqtvNKADSRQHPftGSTSNHVVRTSRAEGQTL-VQPSVANRAMRRVSSVPSRA 218
Cdd:pfam03154  120 SSDGR------SVNDEGSSDPKDIDQD---NRSTSPSIP--SPQDNESDSDSSAQQQILqTQPPVLQAQSGAASPPSPPP 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308   219 QSPSYVTSTGVSPSRGSLRTSLGSGFGSPSVTDSRPLNPSAY--SSSTLPAQRAASPYSQ-RPASPTAVRRVGSVTSRQT 295
Cdd:pfam03154  189 PGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQRLPSPHPPlQPMTQPPPPSQVSPQPLPQ 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308   296 SNPNGPVPQYQTTTRVGSPLTLTDAQTR----VASPSQGQVG-SSSPKRSGMTAVPQHLGPSLQRTvhdmdqfgQQQYDI 370
Cdd:pfam03154  269 PSLHGQMPPMPHSLQTGPSHMQHPVPPQpfplTPQSSQSQVPpGPSPAAPGQSQQRIHTPPSQSQL--------QSQQPP 340

                          330
                   ....*....|..
gi 568916308   371 YERMVPPRPDSL 382
Cdd:pfam03154  341 REQPLPPAPLSM 352
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 863-898 2.55e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 2.55e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 568916308   863 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 898
Cdd:pfam00514    5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 846-967 1.22e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.17  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308  846 GSLQNLSA---GNWkfAAYIRAAvrkekGLPILVELLRMDNDRVVSSVATALRNMAL---DVRNKeLIGKYAMRDLVNRL 919
Cdd:PLN03200  169 GALRNLCGstdGFW--SATLEAG-----GVDILVKLLSSGNSDAQANAASLLARLMMafeSSISK-VLDAGAVKQLLKLL 240

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568916308  920 PGGNGPSILsdetvAAICCALHEVTSKNMENAKALADSGGIEKLVNIT 967
Cdd:PLN03200  241 GQGNEVSVR-----AEAAGALEALSSQSKEAKQAIADAGGIPALINAT 283
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 220-377 1.57e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 42.61  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308  220 SPSYVTSTGVSPSRGSLRTSlgsgfgspSVTDSRPLNPSAYSSSTLPA----------QRAASPY----------SQRPA 279
Cdd:PLN03209  385 SPIPTPPSSSPASSKSVDAV--------AKPAEPDVVPSPGSASNVPEvepaqveakkTRPLSPYaryedlkpptSPSPT 456

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308  280 SPTAVRRVGSVTSRQTSNPNGPVPQYQTTT--------RVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGP 351
Cdd:PLN03209  457 APTGVSPSVSSTSSVPAVPDTAPATAATDAaapppanmRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSA 536

                         170       180       190
                  ....*....|....*....|....*....|.
gi 568916308  352 SLQRTVHDMDQFGQQQ-----YDIYERMVPP 377
Cdd:PLN03209  537 PPTALADEQHHAQPKPrplspYTMYEDLKPP 567
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 947-991 3.63e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 3.63e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 568916308    947 NMENAKALADSGGIEKLVNITKgrgdRSSLKVVKAAAQVLNTLWQ 991
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 528-642 6.35e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.86  E-value: 6.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568916308  528 LPEVIHMLQHQFPSVQANAAAYLQHLCfGDNKVKMEVYrLGG-IKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDEnkI 606
Cdd:PLN03200   60 MPLLVSLLRSGTLGAKVNAAAVLGVLC-KEEDLRVKVL-LGGcIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDH--V 135

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 568916308  607 AMK---NVGGIPALLRLL--RKSIDAEVRELVTGVLWNLSS 642
Cdd:PLN03200  136 GSKifsTEGVVPSLWDQLqpGNKQDKVVEGLLTGALRNLCG 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH