NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568922797|ref|XP_006501546|]
View 

B-cell scaffold protein with ankyrin repeats isoform X1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TIR_3 pfam18567
Toll/interleukin-1 receptor domain; This is a Toll/interleukin-1 receptor (TIR) domain found ...
 28-153 3.73e-41

Toll/interleukin-1 receptor domain; This is a Toll/interleukin-1 receptor (TIR) domain found in the N-terminal region of B-cell adaptor for phosphoinositide 3-kinase (BCAP). BCAP functions in linking the B-cell receptor (BCR) and the co-receptor CD19 to the activation of PI3K via interaction with the SH2 domains on the regulatory p85 subunit. BCAP TIR associates with the MAL/TIRAP adaptor and the TIR domains of Toll-like receptors (TLRs).


:

Pssm-ID: 436583  Cd Length: 128  Bit Score: 146.60  E-value: 3.73e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922797   28 DILLLYEEDAEEWALYLREIFMRVVEREAILLYPLHSFSSSHLEMLNFYAYKCKLLIISNSLLKDLTPKKCQFLEKILHS 107
Cdd:pfam18567   1 DILIVYEEEAEEWATYLQSLFVSSVRELGILLYNLEDTSLEHLDLLSFKSYKCILLLLSAGLLECLKPKVLEFLQRVLHP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 568922797  108 TGNVVTLLCGMESSDPFYQLLSIPRKRW-EISTEQDPDGYISVIRQI 153
Cdd:pfam18567  81 PHRVVVLLCGVHESYELLEEFFSDWEIWqEISCDDEPEEYISAVRKI 127
DBB super family cl20562
Dof, BCAP, and BANK (DBB) motif,; The DBB domain is named from the Drosophila (Downstream of ...
 198-327 6.05e-27

Dof, BCAP, and BANK (DBB) motif,; The DBB domain is named from the Drosophila (Downstream of FGFR - Dof, also known as Heartbroken or Stumps) protein, the BANKS and BCAP, both signalling in B-cell pathway, proteins. This domain defines a minimal region required for mediating Dof dimerization. Since this domain can interact both with itself and with a region in the C-terminal part of the molecule, it may mediate either intermolecular or intramolecular interactions. Mutants lacking this domain disrupt FGFR signal transduction and fibroblast growth-factor signalling. The DBB domain of BCAP mediates BCAP TIR dimerization and negatively regulates TLR signalling.


The actual alignment was detected with superfamily member pfam14545:

Pssm-ID: 464205  Cd Length: 139  Bit Score: 106.53  E-value: 6.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922797  198 LVLPGEIPCEKPGEIFILLKDELIGEI-LEVEFISTN-KRLRARPARWNKSVWHMKAADFPAGSVTVNIHCDGIIKATTE 275
Cdd:pfam14545   1 LVQPSRIKCGSQNKVFILLKEPLDKEDsVEVEFSGNNeQIKRVNAKLENPYTLQFNAPDFPSGLVSVTVYSGGLSLGTRQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568922797  276 IKYCSAAKATESPFR-VSDPGKSLCQ------KSIEELDNVLASIFKREIPYYEFKHLQ 327
Cdd:pfam14545  81 VKYYSRMEEIEQLLKsVADPVEFMCQafgissNDTEKLDQLLTSSLKKNMPPSGFHLLG 139
 
Name Accession Description Interval E-value
TIR_3 pfam18567
Toll/interleukin-1 receptor domain; This is a Toll/interleukin-1 receptor (TIR) domain found ...
 28-153 3.73e-41

Toll/interleukin-1 receptor domain; This is a Toll/interleukin-1 receptor (TIR) domain found in the N-terminal region of B-cell adaptor for phosphoinositide 3-kinase (BCAP). BCAP functions in linking the B-cell receptor (BCR) and the co-receptor CD19 to the activation of PI3K via interaction with the SH2 domains on the regulatory p85 subunit. BCAP TIR associates with the MAL/TIRAP adaptor and the TIR domains of Toll-like receptors (TLRs).


Pssm-ID: 436583  Cd Length: 128  Bit Score: 146.60  E-value: 3.73e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922797   28 DILLLYEEDAEEWALYLREIFMRVVEREAILLYPLHSFSSSHLEMLNFYAYKCKLLIISNSLLKDLTPKKCQFLEKILHS 107
Cdd:pfam18567   1 DILIVYEEEAEEWATYLQSLFVSSVRELGILLYNLEDTSLEHLDLLSFKSYKCILLLLSAGLLECLKPKVLEFLQRVLHP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 568922797  108 TGNVVTLLCGMESSDPFYQLLSIPRKRW-EISTEQDPDGYISVIRQI 153
Cdd:pfam18567  81 PHRVVVLLCGVHESYELLEEFFSDWEIWqEISCDDEPEEYISAVRKI 127
DBB pfam14545
Dof, BCAP, and BANK (DBB) motif,; The DBB domain is named from the Drosophila (Downstream of ...
 198-327 6.05e-27

Dof, BCAP, and BANK (DBB) motif,; The DBB domain is named from the Drosophila (Downstream of FGFR - Dof, also known as Heartbroken or Stumps) protein, the BANKS and BCAP, both signalling in B-cell pathway, proteins. This domain defines a minimal region required for mediating Dof dimerization. Since this domain can interact both with itself and with a region in the C-terminal part of the molecule, it may mediate either intermolecular or intramolecular interactions. Mutants lacking this domain disrupt FGFR signal transduction and fibroblast growth-factor signalling. The DBB domain of BCAP mediates BCAP TIR dimerization and negatively regulates TLR signalling.


Pssm-ID: 464205  Cd Length: 139  Bit Score: 106.53  E-value: 6.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922797  198 LVLPGEIPCEKPGEIFILLKDELIGEI-LEVEFISTN-KRLRARPARWNKSVWHMKAADFPAGSVTVNIHCDGIIKATTE 275
Cdd:pfam14545   1 LVQPSRIKCGSQNKVFILLKEPLDKEDsVEVEFSGNNeQIKRVNAKLENPYTLQFNAPDFPSGLVSVTVYSGGLSLGTRQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568922797  276 IKYCSAAKATESPFR-VSDPGKSLCQ------KSIEELDNVLASIFKREIPYYEFKHLQ 327
Cdd:pfam14545  81 VKYYSRMEEIEQLLKsVADPVEFMCQafgissNDTEKLDQLLTSSLKKNMPPSGFHLLG 139
 
Name Accession Description Interval E-value
TIR_3 pfam18567
Toll/interleukin-1 receptor domain; This is a Toll/interleukin-1 receptor (TIR) domain found ...
 28-153 3.73e-41

Toll/interleukin-1 receptor domain; This is a Toll/interleukin-1 receptor (TIR) domain found in the N-terminal region of B-cell adaptor for phosphoinositide 3-kinase (BCAP). BCAP functions in linking the B-cell receptor (BCR) and the co-receptor CD19 to the activation of PI3K via interaction with the SH2 domains on the regulatory p85 subunit. BCAP TIR associates with the MAL/TIRAP adaptor and the TIR domains of Toll-like receptors (TLRs).


Pssm-ID: 436583  Cd Length: 128  Bit Score: 146.60  E-value: 3.73e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922797   28 DILLLYEEDAEEWALYLREIFMRVVEREAILLYPLHSFSSSHLEMLNFYAYKCKLLIISNSLLKDLTPKKCQFLEKILHS 107
Cdd:pfam18567   1 DILIVYEEEAEEWATYLQSLFVSSVRELGILLYNLEDTSLEHLDLLSFKSYKCILLLLSAGLLECLKPKVLEFLQRVLHP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 568922797  108 TGNVVTLLCGMESSDPFYQLLSIPRKRW-EISTEQDPDGYISVIRQI 153
Cdd:pfam18567  81 PHRVVVLLCGVHESYELLEEFFSDWEIWqEISCDDEPEEYISAVRKI 127
DBB pfam14545
Dof, BCAP, and BANK (DBB) motif,; The DBB domain is named from the Drosophila (Downstream of ...
 198-327 6.05e-27

Dof, BCAP, and BANK (DBB) motif,; The DBB domain is named from the Drosophila (Downstream of FGFR - Dof, also known as Heartbroken or Stumps) protein, the BANKS and BCAP, both signalling in B-cell pathway, proteins. This domain defines a minimal region required for mediating Dof dimerization. Since this domain can interact both with itself and with a region in the C-terminal part of the molecule, it may mediate either intermolecular or intramolecular interactions. Mutants lacking this domain disrupt FGFR signal transduction and fibroblast growth-factor signalling. The DBB domain of BCAP mediates BCAP TIR dimerization and negatively regulates TLR signalling.


Pssm-ID: 464205  Cd Length: 139  Bit Score: 106.53  E-value: 6.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922797  198 LVLPGEIPCEKPGEIFILLKDELIGEI-LEVEFISTN-KRLRARPARWNKSVWHMKAADFPAGSVTVNIHCDGIIKATTE 275
Cdd:pfam14545   1 LVQPSRIKCGSQNKVFILLKEPLDKEDsVEVEFSGNNeQIKRVNAKLENPYTLQFNAPDFPSGLVSVTVYSGGLSLGTRQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568922797  276 IKYCSAAKATESPFR-VSDPGKSLCQ------KSIEELDNVLASIFKREIPYYEFKHLQ 327
Cdd:pfam14545  81 VKYYSRMEEIEQLLKsVADPVEFMCQafgissNDTEKLDQLLTSSLKKNMPPSGFHLLG 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH