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Conserved domains on  [gi|568934211|ref|XP_006504012|]
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PGAP2-interacting protein isoform X2 [Mus musculus]

Protein Classification

endonuclease/exonuclease/phosphatase family protein; endonuclease/exonuclease/phosphatase family protein; reverse transcriptase family protein; reverse transcriptase family protein( domain architecture ID 10007571)

endonuclease/exonuclease/phosphatase (EEP) family protein ration; endonuclease/exonuclease/phosphatase (EEP) family protein similar to PGAP2-interacting protein, which is involved in lipid remodeling during glycosylphosphatidylinositol (GPI)-anchor maturation; endonuclease/exonuclease/phosphatase (EEP) family protein ration; endonuclease/exonuclease/phosphatase (EEP) family protein similar to PGAP2-interacting protein, which is involved in lipid remodeling during glycosylphosphatidylinositol (GPI)-anchor maturation; reverse transcriptase (RT) family protein containing an exonuclease-endonuclease phosphatase (EEP) domain; RT catalyzes the conversion of single-stranded RNA into double-stranded DNA for integration into host chromosomes; may be a fragment of a retrovirus-related Pol polyprotein; reverse transcriptase (RT) family protein containing an exonuclease-endonuclease phosphatase (EEP) domain; RT catalyzes the conversion of single-stranded RNA into double-stranded DNA for integration into host chromosomes; may be a fragment of a retrovirus-related Pol polyprotein

Gene Ontology:  GO:0003824

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ElsH COG3568
Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function ...
 400-476 8.41e-10

Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function prediction only];


:

Pssm-ID: 442789 [Multi-domain]  Cd Length: 167  Bit Score: 58.00  E-value: 8.41e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568934211 400 IMVLSRYPIVRSEHHLLPSPEGEIAPAITMTVNVSNRLVDFVVTHFGnHEDDLDRKLQAIAVSKLLKNCSNQ--VIFLG 476
Cdd:COG3568   47 NAILSRYPIVSSGTFDLPDPGGEPRGALWADVDVPGKPLRVVNTHLD-LRSAAARRRQARALAELLAELPAGapVILAG 124
 
Name Accession Description Interval E-value
ElsH COG3568
Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function ...
 400-476 8.41e-10

Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function prediction only];


Pssm-ID: 442789 [Multi-domain]  Cd Length: 167  Bit Score: 58.00  E-value: 8.41e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568934211 400 IMVLSRYPIVRSEHHLLPSPEGEIAPAITMTVNVSNRLVDFVVTHFGnHEDDLDRKLQAIAVSKLLKNCSNQ--VIFLG 476
Cdd:COG3568   47 NAILSRYPIVSSGTFDLPDPGGEPRGALWADVDVPGKPLRVVNTHLD-LRSAAARRRQARALAELLAELPAGapVILAG 124
Exo_endo_phos pfam03372
Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium ...
 354-476 7.33e-03

Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.


Pssm-ID: 460902 [Multi-domain]  Cd Length: 183  Bit Score: 37.97  E-value: 7.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934211  354 GADFITILESDASkpyiGNNDLTMWLGEKLGFYTDFGPSTRDHTWGIMVLSRYPIVRSEHHLLPS---PEGEIAPAITMT 430
Cdd:pfam03372  30 DPDVVALQETDDD----DASRLLLALLAYGGFLSYGGPGGGGGGGGVAILSRYPLSSVILVDLGEfgdPALRGAIAPFAG 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 568934211  431 VNVSNRLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKNCSNQVIFLG 476
Cdd:pfam03372 106 VLVVPLVLTLAPHASPRLARDEQRADLLLLLLALLAPRSEPVILAG 151
 
Name Accession Description Interval E-value
ElsH COG3568
Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function ...
 400-476 8.41e-10

Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function prediction only];


Pssm-ID: 442789 [Multi-domain]  Cd Length: 167  Bit Score: 58.00  E-value: 8.41e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568934211 400 IMVLSRYPIVRSEHHLLPSPEGEIAPAITMTVNVSNRLVDFVVTHFGnHEDDLDRKLQAIAVSKLLKNCSNQ--VIFLG 476
Cdd:COG3568   47 NAILSRYPIVSSGTFDLPDPGGEPRGALWADVDVPGKPLRVVNTHLD-LRSAAARRRQARALAELLAELPAGapVILAG 124
Exo_endo_phos pfam03372
Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium ...
 354-476 7.33e-03

Endonuclease/Exonuclease/phosphatase family; This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.


Pssm-ID: 460902 [Multi-domain]  Cd Length: 183  Bit Score: 37.97  E-value: 7.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568934211  354 GADFITILESDASkpyiGNNDLTMWLGEKLGFYTDFGPSTRDHTWGIMVLSRYPIVRSEHHLLPS---PEGEIAPAITMT 430
Cdd:pfam03372  30 DPDVVALQETDDD----DASRLLLALLAYGGFLSYGGPGGGGGGGGVAILSRYPLSSVILVDLGEfgdPALRGAIAPFAG 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 568934211  431 VNVSNRLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKNCSNQVIFLG 476
Cdd:pfam03372 106 VLVVPLVLTLAPHASPRLARDEQRADLLLLLLALLAPRSEPVILAG 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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