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Conserved domains on  [gi|568939356|ref|XP_006505018|]
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protection of telomeres protein 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pot1C cd20374
Protection Of Telomeres Protein 1 (POT1) C-terminal region; POT1 is part of shelterin, a ...
 290-576 1.38e-163

Protection Of Telomeres Protein 1 (POT1) C-terminal region; POT1 is part of shelterin, a hexameric nucleoprotein complex (comprising TRF1, TRF2, TIN2, RAP1, POT1 and TPP1 in humans) that protects telomeres, the physical ends of chromosomes. Shelterin protects against these ends being recognized as double-stranded DNA breaks, as well as against degradation of the telomeric overhang by endonucleases. It also helps control access of telomerase to the telomeric overhang, thereby affecting telomore length. This C-terminal region has an OB-fold domain and a holiday junction resolvase (HJR) domain which make dimer contacts with TPP1.


:

Pssm-ID: 380669  Cd Length: 286  Bit Score: 467.53  E-value: 1.38e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356 290 LEKTPLCAILTQKAPQQYRVRAKLRSYLPRRLSQSVKLLCPKCHSVQEVPHGDSLDKILQDAATEAPdiklkaTSLYYSK 369
Cdd:cd20374    1 LEQTPLSEVKKSTPPQQYHVRAKLRSYQPQRLYQSVKLFCPKCKSLQEVPDEEALANIFQEAATDSP------TSWYSSE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356 370 VWTTED-----QGGRQVAVHFVKNN-GILPASseCLILIEGGRLCEVSKLSSKFHSVMPVRSGPESLELLTLSAPFLIQG 443
Cdd:cd20374   75 VWTLTGsldsgQGGRKVAVHFVKNMmLQSPEK--ELIFIEGGTLEEICKLSKKFKNIIPVRSSEEDLTLLDLSAPFLFQG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356 444 KVHHYGCKQCSSLKPIQNLNSRFHKGPWTPSSVAEALGVVPLQYVFVMVFTLDDGTGVLEAYL-KDSEHFFKIPASEVLT 522
Cdd:cd20374  153 KKRYYGCKQCSSPKSIENLSSLVEKESWDESSVAEALGIQLLQYVFLMKFTLDDGTGTLEALLwLDAEKFFQISASEVLT 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568939356 523 DDDLQRSLETIMDMICPPGIKVDAYPWLECLLKSYNVTIGTERRICYQIFDTTV 576
Cdd:cd20374  233 DQELQEKIQMIMDTLCPPGISIDERPWLECCIKSYNVEDGGRNQVCYQIFDTTV 286
POT1PC pfam16686
ssDNA-binding domain of telomere protection protein; POT1PC is the ssDNA-binding domain on a ...
 94-236 6.28e-44

ssDNA-binding domain of telomere protection protein; POT1PC is the ssDNA-binding domain on a family of fungal telomere protection protein 1 proteins. POT1PC is able to accommodate heterogeneous ssDNA ligands. Pot1 proteins are the proteins responsible for binding to and protecting the 3' single-stranded DNA (ssDNA) overhang at most eukaryotic telomeres.


:

Pssm-ID: 435514  Cd Length: 152  Bit Score: 153.58  E-value: 6.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356   94 LCDAQPMQYYDLTCQLLGKAQVDSTAFLLKVWDGTQTVLPSWRVSTQDLTFEGDL--------SHIERLQSLVVDILVYD 165
Cdd:pfam16686   1 LKDVQPGQFFDLIVQVVKKAYDDGGKVLLYVWDYTENPPLFLYVSPEDGDFRGDDddfkprigKWIGPFGKLTLQITLYD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568939356  166 NHVQVARS-IEVGCFLRLYSLHTKLQPGNsetsssesLRLEFHLHGGTSYGRGIRVL---PDTSPCVDQLKKALE 236
Cdd:pfam16686  81 PHASFAREnLKPGDFVRLRNVHIKYGRNG--------LNLEGVLHGDRGYGRGIIVLvidDNNDPRLKELKRRKR 147
Telo_bind smart00976
Telomeric single stranded DNA binding POT1/CDC13; The telomere-binding protein forms a ...
 1-82 1.06e-22

Telomeric single stranded DNA binding POT1/CDC13; The telomere-binding protein forms a heterodimer in ciliates consisting of an alpha and a beta subunit. This complex may function as a protective cap for the single-stranded telomeric overhang. Alpha subunit consists of 3 structural domains, all with the same beta-barrel OB fold.


:

Pssm-ID: 214949  Cd Length: 137  Bit Score: 93.92  E-value: 1.06e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356     1 MLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINCSGFASLTFEGTVGMPVTARTSSKVFSFTPQDQKM-VEALRV 79
Cdd:smart00976  55 KLFSPTLESLPVIKYVGDIILLHRVKIQDFNNRIQGLCSFGTSSWAVFGPLNGVVRERESSPPSTFTPEDEKQyVEELRN 134


                   ...
gi 568939356    80 WAS 82
Cdd:smart00976 135 WAF 137
 
Name Accession Description Interval E-value
Pot1C cd20374
Protection Of Telomeres Protein 1 (POT1) C-terminal region; POT1 is part of shelterin, a ...
 290-576 1.38e-163

Protection Of Telomeres Protein 1 (POT1) C-terminal region; POT1 is part of shelterin, a hexameric nucleoprotein complex (comprising TRF1, TRF2, TIN2, RAP1, POT1 and TPP1 in humans) that protects telomeres, the physical ends of chromosomes. Shelterin protects against these ends being recognized as double-stranded DNA breaks, as well as against degradation of the telomeric overhang by endonucleases. It also helps control access of telomerase to the telomeric overhang, thereby affecting telomore length. This C-terminal region has an OB-fold domain and a holiday junction resolvase (HJR) domain which make dimer contacts with TPP1.


Pssm-ID: 380669  Cd Length: 286  Bit Score: 467.53  E-value: 1.38e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356 290 LEKTPLCAILTQKAPQQYRVRAKLRSYLPRRLSQSVKLLCPKCHSVQEVPHGDSLDKILQDAATEAPdiklkaTSLYYSK 369
Cdd:cd20374    1 LEQTPLSEVKKSTPPQQYHVRAKLRSYQPQRLYQSVKLFCPKCKSLQEVPDEEALANIFQEAATDSP------TSWYSSE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356 370 VWTTED-----QGGRQVAVHFVKNN-GILPASseCLILIEGGRLCEVSKLSSKFHSVMPVRSGPESLELLTLSAPFLIQG 443
Cdd:cd20374   75 VWTLTGsldsgQGGRKVAVHFVKNMmLQSPEK--ELIFIEGGTLEEICKLSKKFKNIIPVRSSEEDLTLLDLSAPFLFQG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356 444 KVHHYGCKQCSSLKPIQNLNSRFHKGPWTPSSVAEALGVVPLQYVFVMVFTLDDGTGVLEAYL-KDSEHFFKIPASEVLT 522
Cdd:cd20374  153 KKRYYGCKQCSSPKSIENLSSLVEKESWDESSVAEALGIQLLQYVFLMKFTLDDGTGTLEALLwLDAEKFFQISASEVLT 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568939356 523 DDDLQRSLETIMDMICPPGIKVDAYPWLECLLKSYNVTIGTERRICYQIFDTTV 576
Cdd:cd20374  233 DQELQEKIQMIMDTLCPPGISIDERPWLECCIKSYNVEDGGRNQVCYQIFDTTV 286
POT1PC pfam16686
ssDNA-binding domain of telomere protection protein; POT1PC is the ssDNA-binding domain on a ...
 94-236 6.28e-44

ssDNA-binding domain of telomere protection protein; POT1PC is the ssDNA-binding domain on a family of fungal telomere protection protein 1 proteins. POT1PC is able to accommodate heterogeneous ssDNA ligands. Pot1 proteins are the proteins responsible for binding to and protecting the 3' single-stranded DNA (ssDNA) overhang at most eukaryotic telomeres.


Pssm-ID: 435514  Cd Length: 152  Bit Score: 153.58  E-value: 6.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356   94 LCDAQPMQYYDLTCQLLGKAQVDSTAFLLKVWDGTQTVLPSWRVSTQDLTFEGDL--------SHIERLQSLVVDILVYD 165
Cdd:pfam16686   1 LKDVQPGQFFDLIVQVVKKAYDDGGKVLLYVWDYTENPPLFLYVSPEDGDFRGDDddfkprigKWIGPFGKLTLQITLYD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568939356  166 NHVQVARS-IEVGCFLRLYSLHTKLQPGNsetsssesLRLEFHLHGGTSYGRGIRVL---PDTSPCVDQLKKALE 236
Cdd:pfam16686  81 PHASFAREnLKPGDFVRLRNVHIKYGRNG--------LNLEGVLHGDRGYGRGIIVLvidDNNDPRLKELKRRKR 147
hPOT1_OB2 cd04498
hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of ...
 102-221 1.67e-37

hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with the sequence GGTTAG. The hPOT1 monomer consists of two closely connected OB folds (OB1-OB2) which cooperate to bind telomeric ssDNA. OB1 makes more extensive contact with the ssDNA than OB2. OB2 protects the 3' end of the ssDNA. hPOT1 is implicated in telomere length regulation.


Pssm-ID: 239944  Cd Length: 123  Bit Score: 134.85  E-value: 1.67e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356 102 YYDLTCQLLGKAQVDSTAFLLKVWDGTQTVLPSWRVSTQDLTF-EGDLSHIERLQS---LVVDILVYDNHVQVARSIEVG 177
Cdd:cd04498    1 YFDLLCQLLSVVETDSSSTLLKVWDGTKFPPPLRKVKVEDDVVlEGDRSLKHREEGgkqLTIDILVYDNHVELAKSLKPG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568939356 178 CFLRLYSLHTKlqPGNSETSSSESLRLEFHL-HGGTSYGRGIRVL 221
Cdd:cd04498   81 DFVRIYNVHAK--SYSSKNEHDENDHLHFHLvHGGTEYGRGIRVL 123
Telo_bind smart00976
Telomeric single stranded DNA binding POT1/CDC13; The telomere-binding protein forms a ...
 1-82 1.06e-22

Telomeric single stranded DNA binding POT1/CDC13; The telomere-binding protein forms a heterodimer in ciliates consisting of an alpha and a beta subunit. This complex may function as a protective cap for the single-stranded telomeric overhang. Alpha subunit consists of 3 structural domains, all with the same beta-barrel OB fold.


Pssm-ID: 214949  Cd Length: 137  Bit Score: 93.92  E-value: 1.06e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356     1 MLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINCSGFASLTFEGTVGMPVTARTSSKVFSFTPQDQKM-VEALRV 79
Cdd:smart00976  55 KLFSPTLESLPVIKYVGDIILLHRVKIQDFNNRIQGLCSFGTSSWAVFGPLNGVVRERESSPPSTFTPEDEKQyVEELRN 134


                   ...
gi 568939356    80 WAS 82
Cdd:smart00976 135 WAF 137
hPOT1_OB1_like cd04497
hPOT1_OB1_like: A subfamily of OB folds similar to the first OB fold (OB1) of human protection ...
 1-82 1.57e-19

hPOT1_OB1_like: A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal domain of the alpha subunit (OB1Nalpha) of Oxytricha nova telomere end binding protein (OnTEBP). POT1 proteins recognize single-stranded (ss) 3-prime ends of the telomere. A 3-prime ss overhang is conserved in ciliated protozoa, yeast, and mammals. SpPOT1 is essential for telomere maintenance. It binds specifically to the ss G-rich telomeric sequence (GGTTAC) of S. pombe. hPOT1 binds specifically to ss telomeric DNA repeats ending with the sequence GGTTAG. Deletion of the S. pombe pot1+ gene results in a rapid loss of telomere sequences, chromosome mis-segregation and chromosome circularization. hPOT1 is implicated in telomere length regulation. The hPOT1 monomer consists of two closely connected OB folds (OB1-OB2) which cooperate to bind telomeric ssDNA. OB1 makes more extensive contact with the ssDNA than OB2. OB2 protects the 3' end of the ssDNA. A second OB fold has not been predicted in S. pombe POT1. OnTEBP binds the extreme 3-prime end of telomeric DNA. It is heterodimeric and contains four OB folds - three in the alpha subunit (two in the N-terminal domain and one in the C-terminal domain) and one in the beta subunit. OB1Nalpha, together with the second OB fold of the N-terminal domain of OnTEBP alpha subunit and the beta subunit OB fold, forms a deep cleft that binds ssDNA.


Pssm-ID: 239943  Cd Length: 138  Bit Score: 85.02  E-value: 1.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356   1 MLFSGNYEALPIIyKVGDIVRFHRLKIQVYKNELQGI-NCSGFASLTFEGTVGMPVTARTSSKVFSFTPQDQKMVEALRV 79
Cdd:cd04497   57 KLFRPNEESLPIV-KVGDIILLRRVKIQSYNGKPQGIsNDRGSSWAVFRGDDGVVPIPQQSSKPVEFGPEEEPSVEELRK 135


                 ...
gi 568939356  80 WAS 82
Cdd:cd04497  136 WAS 138
POT1 pfam02765
Telomeric single stranded DNA binding POT1/CDC13; This domain binds single stranded telomeric ...
 1-82 7.61e-18

Telomeric single stranded DNA binding POT1/CDC13; This domain binds single stranded telomeric DNA and adopts an OB fold. It includes the proteins POT1 and CDC13 which have been shown to regulate telomere length, replication and capping. POT1 is one component of the shelterin complex that protects telomere-ends from attack by DNA-repair mechanisms.


Pssm-ID: 397060  Cd Length: 140  Bit Score: 80.09  E-value: 7.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356    1 MLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINCSGFAS--LTFEGTVGMPVTA-RTSSKVFSFTPQDQKMVEAL 77
Cdd:pfam02765  56 VFFRKNFEDLPIVKKVGDIILLHRVKIQSFNGEPQGLANIGFSSswALFNGKLNRLYTPpILGSNFFEFSAEEKKYLESL 135


                  ....*
gi 568939356   78 RVWAS 82
Cdd:pfam02765 136 RKWAE 140
 
Name Accession Description Interval E-value
Pot1C cd20374
Protection Of Telomeres Protein 1 (POT1) C-terminal region; POT1 is part of shelterin, a ...
 290-576 1.38e-163

Protection Of Telomeres Protein 1 (POT1) C-terminal region; POT1 is part of shelterin, a hexameric nucleoprotein complex (comprising TRF1, TRF2, TIN2, RAP1, POT1 and TPP1 in humans) that protects telomeres, the physical ends of chromosomes. Shelterin protects against these ends being recognized as double-stranded DNA breaks, as well as against degradation of the telomeric overhang by endonucleases. It also helps control access of telomerase to the telomeric overhang, thereby affecting telomore length. This C-terminal region has an OB-fold domain and a holiday junction resolvase (HJR) domain which make dimer contacts with TPP1.


Pssm-ID: 380669  Cd Length: 286  Bit Score: 467.53  E-value: 1.38e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356 290 LEKTPLCAILTQKAPQQYRVRAKLRSYLPRRLSQSVKLLCPKCHSVQEVPHGDSLDKILQDAATEAPdiklkaTSLYYSK 369
Cdd:cd20374    1 LEQTPLSEVKKSTPPQQYHVRAKLRSYQPQRLYQSVKLFCPKCKSLQEVPDEEALANIFQEAATDSP------TSWYSSE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356 370 VWTTED-----QGGRQVAVHFVKNN-GILPASseCLILIEGGRLCEVSKLSSKFHSVMPVRSGPESLELLTLSAPFLIQG 443
Cdd:cd20374   75 VWTLTGsldsgQGGRKVAVHFVKNMmLQSPEK--ELIFIEGGTLEEICKLSKKFKNIIPVRSSEEDLTLLDLSAPFLFQG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356 444 KVHHYGCKQCSSLKPIQNLNSRFHKGPWTPSSVAEALGVVPLQYVFVMVFTLDDGTGVLEAYL-KDSEHFFKIPASEVLT 522
Cdd:cd20374  153 KKRYYGCKQCSSPKSIENLSSLVEKESWDESSVAEALGIQLLQYVFLMKFTLDDGTGTLEALLwLDAEKFFQISASEVLT 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568939356 523 DDDLQRSLETIMDMICPPGIKVDAYPWLECLLKSYNVTIGTERRICYQIFDTTV 576
Cdd:cd20374  233 DQELQEKIQMIMDTLCPPGISIDERPWLECCIKSYNVEDGGRNQVCYQIFDTTV 286
POT1PC pfam16686
ssDNA-binding domain of telomere protection protein; POT1PC is the ssDNA-binding domain on a ...
 94-236 6.28e-44

ssDNA-binding domain of telomere protection protein; POT1PC is the ssDNA-binding domain on a family of fungal telomere protection protein 1 proteins. POT1PC is able to accommodate heterogeneous ssDNA ligands. Pot1 proteins are the proteins responsible for binding to and protecting the 3' single-stranded DNA (ssDNA) overhang at most eukaryotic telomeres.


Pssm-ID: 435514  Cd Length: 152  Bit Score: 153.58  E-value: 6.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356   94 LCDAQPMQYYDLTCQLLGKAQVDSTAFLLKVWDGTQTVLPSWRVSTQDLTFEGDL--------SHIERLQSLVVDILVYD 165
Cdd:pfam16686   1 LKDVQPGQFFDLIVQVVKKAYDDGGKVLLYVWDYTENPPLFLYVSPEDGDFRGDDddfkprigKWIGPFGKLTLQITLYD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568939356  166 NHVQVARS-IEVGCFLRLYSLHTKLQPGNsetsssesLRLEFHLHGGTSYGRGIRVL---PDTSPCVDQLKKALE 236
Cdd:pfam16686  81 PHASFAREnLKPGDFVRLRNVHIKYGRNG--------LNLEGVLHGDRGYGRGIIVLvidDNNDPRLKELKRRKR 147
hPOT1_OB2 cd04498
hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of ...
 102-221 1.67e-37

hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with the sequence GGTTAG. The hPOT1 monomer consists of two closely connected OB folds (OB1-OB2) which cooperate to bind telomeric ssDNA. OB1 makes more extensive contact with the ssDNA than OB2. OB2 protects the 3' end of the ssDNA. hPOT1 is implicated in telomere length regulation.


Pssm-ID: 239944  Cd Length: 123  Bit Score: 134.85  E-value: 1.67e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356 102 YYDLTCQLLGKAQVDSTAFLLKVWDGTQTVLPSWRVSTQDLTF-EGDLSHIERLQS---LVVDILVYDNHVQVARSIEVG 177
Cdd:cd04498    1 YFDLLCQLLSVVETDSSSTLLKVWDGTKFPPPLRKVKVEDDVVlEGDRSLKHREEGgkqLTIDILVYDNHVELAKSLKPG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568939356 178 CFLRLYSLHTKlqPGNSETSSSESLRLEFHL-HGGTSYGRGIRVL 221
Cdd:cd04498   81 DFVRIYNVHAK--SYSSKNEHDENDHLHFHLvHGGTEYGRGIRVL 123
Telo_bind smart00976
Telomeric single stranded DNA binding POT1/CDC13; The telomere-binding protein forms a ...
 1-82 1.06e-22

Telomeric single stranded DNA binding POT1/CDC13; The telomere-binding protein forms a heterodimer in ciliates consisting of an alpha and a beta subunit. This complex may function as a protective cap for the single-stranded telomeric overhang. Alpha subunit consists of 3 structural domains, all with the same beta-barrel OB fold.


Pssm-ID: 214949  Cd Length: 137  Bit Score: 93.92  E-value: 1.06e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356     1 MLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINCSGFASLTFEGTVGMPVTARTSSKVFSFTPQDQKM-VEALRV 79
Cdd:smart00976  55 KLFSPTLESLPVIKYVGDIILLHRVKIQDFNNRIQGLCSFGTSSWAVFGPLNGVVRERESSPPSTFTPEDEKQyVEELRN 134


                   ...
gi 568939356    80 WAS 82
Cdd:smart00976 135 WAF 137
hPOT1_OB1_like cd04497
hPOT1_OB1_like: A subfamily of OB folds similar to the first OB fold (OB1) of human protection ...
 1-82 1.57e-19

hPOT1_OB1_like: A subfamily of OB folds similar to the first OB fold (OB1) of human protection of telomeres 1 protein (hPOT1), the single OB fold of the N-terminal domain of Schizosaccharomyces pombe POT1 (SpPOT1), and the first OB fold of the N-terminal domain of the alpha subunit (OB1Nalpha) of Oxytricha nova telomere end binding protein (OnTEBP). POT1 proteins recognize single-stranded (ss) 3-prime ends of the telomere. A 3-prime ss overhang is conserved in ciliated protozoa, yeast, and mammals. SpPOT1 is essential for telomere maintenance. It binds specifically to the ss G-rich telomeric sequence (GGTTAC) of S. pombe. hPOT1 binds specifically to ss telomeric DNA repeats ending with the sequence GGTTAG. Deletion of the S. pombe pot1+ gene results in a rapid loss of telomere sequences, chromosome mis-segregation and chromosome circularization. hPOT1 is implicated in telomere length regulation. The hPOT1 monomer consists of two closely connected OB folds (OB1-OB2) which cooperate to bind telomeric ssDNA. OB1 makes more extensive contact with the ssDNA than OB2. OB2 protects the 3' end of the ssDNA. A second OB fold has not been predicted in S. pombe POT1. OnTEBP binds the extreme 3-prime end of telomeric DNA. It is heterodimeric and contains four OB folds - three in the alpha subunit (two in the N-terminal domain and one in the C-terminal domain) and one in the beta subunit. OB1Nalpha, together with the second OB fold of the N-terminal domain of OnTEBP alpha subunit and the beta subunit OB fold, forms a deep cleft that binds ssDNA.


Pssm-ID: 239943  Cd Length: 138  Bit Score: 85.02  E-value: 1.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356   1 MLFSGNYEALPIIyKVGDIVRFHRLKIQVYKNELQGI-NCSGFASLTFEGTVGMPVTARTSSKVFSFTPQDQKMVEALRV 79
Cdd:cd04497   57 KLFRPNEESLPIV-KVGDIILLRRVKIQSYNGKPQGIsNDRGSSWAVFRGDDGVVPIPQQSSKPVEFGPEEEPSVEELRK 135


                 ...
gi 568939356  80 WAS 82
Cdd:cd04497  136 WAS 138
POT1 pfam02765
Telomeric single stranded DNA binding POT1/CDC13; This domain binds single stranded telomeric ...
 1-82 7.61e-18

Telomeric single stranded DNA binding POT1/CDC13; This domain binds single stranded telomeric DNA and adopts an OB fold. It includes the proteins POT1 and CDC13 which have been shown to regulate telomere length, replication and capping. POT1 is one component of the shelterin complex that protects telomere-ends from attack by DNA-repair mechanisms.


Pssm-ID: 397060  Cd Length: 140  Bit Score: 80.09  E-value: 7.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568939356    1 MLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINCSGFAS--LTFEGTVGMPVTA-RTSSKVFSFTPQDQKMVEAL 77
Cdd:pfam02765  56 VFFRKNFEDLPIVKKVGDIILLHRVKIQSFNGEPQGLANIGFSSswALFNGKLNRLYTPpILGSNFFEFSAEEKKYLESL 135


                  ....*
gi 568939356   78 RVWAS 82
Cdd:pfam02765 136 RKWAE 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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