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Conserved domains on  [gi|568941324|ref|XP_006505926|]
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substance-P receptor isoform X1 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
33-316 1.81e-170

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd16002:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 284  Bit Score: 477.82  E-value: 1.81e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd16002    1 ALWAVAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTY 192
Cdd:cd16002   81 IAAVFASIYSMTAIALDRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPEHEERKY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 193 EKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPY 272
Cdd:cd16002  161 ETVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQY 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568941324 273 INPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd16002  241 FHPELYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRVGF 284
 
Name Accession Description Interval E-value
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
33-316 1.81e-170

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 477.82  E-value: 1.81e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd16002    1 ALWAVAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTY 192
Cdd:cd16002   81 IAAVFASIYSMTAIALDRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPEHEERKY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 193 EKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPY 272
Cdd:cd16002  161 ETVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQY 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568941324 273 INPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd16002  241 FHPELYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRVGF 284
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
54-305 6.19e-65

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 207.92  E-value: 6.19e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324   54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAV-HNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:pfam00001   6 ILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLnHGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  133 AIIHPLQ--PRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMP--SRVVCMIEWPEHPnrTYEKAYHICVTVLIYFLP 208
Cdd:pfam00001  86 AIVHPLRykRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPegNVTVCFIDFPEDL--SKPVSYTLLISVLGFLLP 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  209 LLVIGYAYTVVGITLWASEIPGDSSDRYHeqvsAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYL 288
Cdd:pfam00001 164 LLVILVCYTLIIRTLRKSASKQKSSERTQ----RRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLDKALS 239
                         250
                  ....*....|....*..
gi 568941324  289 ASMWLAMSSTMYNPIIY 305
Cdd:pfam00001 240 VTLWLAYVNSCLNPIIY 256
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
54-321 1.67e-10

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 62.34  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMaafntVVNFTYAVHN---VWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:PHA02638 119 IIMILFCKKIKTITDIYIFNLAISDLIF-----VIDFPFIIYNefdQWIFGDFMCKVISASYYIGFFSNMFLITLMSIDR 193
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQPRLSATATKVVIFVI--WVLALLLAFPQGYY-----------STTETMPSRVVCMIEWPEHPNRTY-EKAY 196
Cdd:PHA02638 194 YFAILYPISFQKYRTFNIGIILCIisWILSLIITSPAYFIfeasniifsaqDSNETISNYQCTLIEDNEKNNISFlGRIL 273
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 197 HICVTVLIYFLPLLVIGYAYTVVGITLwaseipgdssdRYHEQVSAKRKVVKMMIVVVCTFaICWLPFHIFFLLPYINP- 275
Cdd:PHA02638 274 QFEINILGMFIPIIIFAFCYIKIILKL-----------KQLKKSKKTKSIIIVSIIIICSL-ICWIPLNIVILFATMYSf 341
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568941324 276 -------DLYLKKFIQQVYLASMWLAMSST--MYNPIIYCCLNDRFRLGFKHAFR 321
Cdd:PHA02638 342 kgfnsiiSEHICGFIKLGYAMMLAEAISLThcCINPLIYTLIGENFRMHLLMIFR 396
 
Name Accession Description Interval E-value
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
33-316 1.81e-170

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 477.82  E-value: 1.81e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd16002    1 ALWAVAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTY 192
Cdd:cd16002   81 IAAVFASIYSMTAIALDRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPEHEERKY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 193 EKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPY 272
Cdd:cd16002  161 ETVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQY 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568941324 273 INPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd16002  241 FHPELYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
33-316 9.26e-143

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 407.84  E-value: 9.26e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd15390    1 VLWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMP-----SRVVCMIEWPEH 187
Cdd:cd15390   81 ITTVAASVFTLMAISIDRYIAIVHPLRPRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETYYyytgsERTVCFIAWPDG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 188 PNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIF 267
Cdd:cd15390  161 PNSLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGENTPRQLESVRAKRKVVKMMIVVVVIFAICWLPYHLY 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 568941324 268 FLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15390  241 FILTYLYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-316 6.84e-139

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 397.76  E-value: 6.84e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  34 LWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPI 113
Cdd:cd16003    2 LWSLAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 114 AALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYe 193
Cdd:cd16003   82 TSVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVAWPGGPDQHF- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 194 kAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYI 273
Cdd:cd16003  161 -TYHIIVIVLVYCLPLLVMGITYTIVGITLWGGEIPGDTSDKYHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFIVTGL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568941324 274 NPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd16003  240 YQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
33-316 4.64e-132

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 380.70  E-value: 4.64e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd15202    1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETM-----PSRVVCMIEWPEH 187
Cdd:cd15202   81 YCSVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHAICSKLETFkysedIVRSLCLEDWPER 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 188 PnRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDS-SDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHI 266
Cdd:cd15202  161 A-DLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGDAtTERYFALRRKKKKVIKMLMVVVVLFALCWLPFNI 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 568941324 267 FFLLPYINPDlYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15202  240 YVLLLSSKPD-YLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-316 2.70e-129

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 373.41  E-value: 2.70e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  34 LWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPI 113
Cdd:cd16004    2 LWAIAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 114 AALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYE 193
Cdd:cd16004   82 TAMFVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAWPGDSGGKHQ 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 194 KAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDS-SDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPY 272
Cdd:cd16004  162 LTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQaHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFILGS 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568941324 273 INPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd16004  242 FNEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
33-316 4.03e-118

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 345.19  E-value: 4.03e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd14992    1 IILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQPR--LSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVC----MIEWPE 186
Cdd:cd14992   81 TVSVYASSLTLTAIAFDRYFAIIHPLKPRhrQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQekifCCQIPP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 187 HPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDS-SDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFH 265
Cdd:cd14992  161 VDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPGFSiKEVERKRLKCKRRVIKMLVCVVVLFVICWLPFH 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568941324 266 IFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd14992  241 LFFLLRDFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
38-316 5.97e-67

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 214.15  E-value: 5.97e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  38 AYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFntVVNFTYA---VHNVWYYGLFYCKFHNFFPIA 114
Cdd:cd15392    6 MYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVF--CVPFSFIallILQYWPFGEFMCPVVNYLQAV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 115 ALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMP----SRVVCMIEWPehpNR 190
Cdd:cd15392   84 SVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIAITSRLFEDSnascGQYICTESWP---SD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 191 TYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGD-SSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFL 269
Cdd:cd15392  161 TNRYIYSLVLMILQYFVPLAVLVFTYTRIGIVVWAKRTPGEaENNRDQRMAESKRKLVKMMITVVAIFALCWLPLNILNL 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568941324 270 LPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15392  241 VGDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
54-305 6.19e-65

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 207.92  E-value: 6.19e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324   54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAV-HNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:pfam00001   6 ILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLnHGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  133 AIIHPLQ--PRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMP--SRVVCMIEWPEHPnrTYEKAYHICVTVLIYFLP 208
Cdd:pfam00001  86 AIVHPLRykRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPegNVTVCFIDFPEDL--SKPVSYTLLISVLGFLLP 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  209 LLVIGYAYTVVGITLWASEIPGDSSDRYHeqvsAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYL 288
Cdd:pfam00001 164 LLVILVCYTLIIRTLRKSASKQKSSERTQ----RRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLDKALS 239
                         250
                  ....*....|....*..
gi 568941324  289 ASMWLAMSSTMYNPIIY 305
Cdd:pfam00001 240 VTLWLAYVNSCLNPIIY 256
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
54-316 2.76e-59

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 194.74  E-value: 2.76e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd14993   22 IAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGVSVSASVLTLVAISIDRYLA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPR--LSATATKVVIFVIWVLALLLAFPQGYYSTTETMPS-------RVVCMIEWpehPNRTYEKAYHICVTVLI 204
Cdd:cd14993  102 ICYPLKARrvSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISsepgtitIYICTEDW---PSPELRKAYNVALFVVL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 205 YFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVS----AKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINP--DLY 278
Cdd:cd14993  179 YVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRrilrSKKKVARMLIVVVVLFALSWLPYYVLSILLDFGPlsSEE 258
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568941324 279 LKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd14993  259 SDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
54-309 1.55e-57

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 189.42  E-value: 1.55e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd00637   20 ILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISVDRYLA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPR--LSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWpehPNRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd00637  100 IVHPLRYRrrFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCW---PDLTLSKAYTIFLFVLLFLLPLLV 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLWASEIPGD---SSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYlkKFIQQVYL 288
Cdd:cd00637  177 IIVCYVRIFRKLRRHRRRIRsssSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPS--PLPRILYF 254
                        250       260
                 ....*....|....*....|.
gi 568941324 289 ASMWLAMSSTMYNPIIYCCLN 309
Cdd:cd00637  255 LALLLAYLNSAINPIIYAFFN 275
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
33-316 4.67e-57

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 188.77  E-value: 4.67e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd15393    1 VLLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSR---VVCMIEWPEHPN 189
Cdd:cd15393   81 VLSVNVSVFTLTVIAVDRYRAVIHPLKARCSKKSAKIIILIIWILALLVALPVALALRVEELTDKtnnGVKPFCLPVGPS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 190 RTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSD-RYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFF 268
Cdd:cd15393  161 DDWWKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGNAQDvRDDEILKNKKKVIKMLIIVVALFALCWLPLQTYN 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568941324 269 LLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15393  241 LLNEIKPEINKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
33-313 1.53e-54

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 182.15  E-value: 1.53e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd15389    1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMP-----SRVVCMIEWPEh 187
Cdd:cd15389   81 YCSVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEysnerTRSRCLPSFPE- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 188 PNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDR-YHEQVSAKRKVVKMMIVVVCTFAICWLPFHI 266
Cdd:cd15389  160 PSDLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLWLRNAIGDVTTEqYVAQRRKKKKTIKMLMLVVLLFAICWLPLNC 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568941324 267 FFLLPYINPDLYlkkfIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15389  240 YHVLLSSHPIRS----NSALFFAFHWLAMSSTCYNPFIYCWLNDSFR 282
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
54-316 1.12e-53

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 180.11  E-value: 1.12e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15203   22 IYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQGVSIFVSTLTLTAIAIDRYQL 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMP------SRVVCMIEWpehPNRTYEKAYHICVTVLIYFL 207
Cdd:cd15203  102 IVYPTRPRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPieilpyCGYFCTESW---PSSSSRLIYTISVLVLQFVI 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 208 PLLVIGYAYTVVGITL-----WASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYL-KK 281
Cdd:cd15203  179 PLLIISFCYFRISLKLrkrvkKKRGKRTLSSRRRRSELRRKRRTNRLLIAMVVVFAVCWLPLNLFNLLRDFEPLPQIdGR 258
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568941324 282 FIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15203  259 HFYLIFLICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
54-313 1.27e-48

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 166.92  E-value: 1.27e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15391   22 IVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGIDRFFA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPS----RVVCMIEWPeHPNrTYEKAYHICVTVLIYFLPL 209
Cdd:cd15391  102 VIFPLRSRHTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYGQysegRVLCGESWP-GPD-TSRSAYTVFVMLLTYIIPL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVGITLWASEIPGDS-SDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKK--FIQQV 286
Cdd:cd15391  180 LILTSTYGYVGFRLWNRTAPGNAdKGRDDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFNLVQDFSTVFRNMPqhTTRLI 259
                        250       260
                 ....*....|....*....|....*..
gi 568941324 287 YLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15391  260 YGACHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
54-316 1.02e-44

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 156.63  E-value: 1.02e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFntVVNFTYaVHNV---WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15207   22 CLVVAKNPRMRTVTNYFILNLAVSDLLVGVF--CMPFTL-VDNIltgWPFGDVMCKLSPLVQGVSVAASVFTLVAIAVDR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRV-----VCMIEWPEHPNRtyeKAYHICVTVLIY 205
Cdd:cd15207   99 YRAVVHPTEPKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRgqtvhICVEFWPSDEYR---KAYTTSLFVLCY 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 206 FLPLLVIGYAYTVVGITLWASEIPGdSSDRYHEQ---VSAKRKVVKMMIVVVCT-FAICWLPFHIFFLL-PYINPDLYLK 280
Cdd:cd15207  176 VAPLLIIAVLYVRIGYRLWFKPVPG-GGSASREAqaaVSKKKVRVIKMLIVVVVlFALSWLPLHTVTMLdDFGNLSPNQR 254
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568941324 281 KFIQQ-VYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15207  255 EVLYVyIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
54-313 3.15e-43

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 152.59  E-value: 3.15e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAV-HNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd15394   22 IYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFePRGWVFGRFMCYFVFLMQPVTVYVSVFTLTAIAVDRYY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVI 212
Cdd:cd15394  102 VTVYPLRRRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKGLDFSICEEFWFGQEKQRLAYACSTLLITYVLPLLAI 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 213 GYAYTVVGITLWASEIPGDSSDRYHEQVSA-KRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLASM 291
Cdd:cd15394  182 SLSYLRISVKLRNRVVPGSMTQSQAEWDRArRRKTFRLLVVVVVAFAICWLPLHIFNVIRDIDIDLIDKQYFNLIQLLCH 261
                        250       260
                 ....*....|....*....|..
gi 568941324 292 WLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15394  262 WLAMSSACYNPFLYAWLHDSFR 283
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
57-316 5.00e-43

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 151.18  E-value: 5.00e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd14967   24 VYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNLCAISLDRYLAITR 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPRLSATATKV--VIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEwpehpnRTYEKAYHICVTVLIYFLPLLVIGY 214
Cdd:cd14967  104 PLRYRQLMTKKRAliMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECE------FTPNKIYVLVSSVISFFIPLLIMIV 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 215 AYTVVGITLwaseipgdssdrYHEQVSAKRkvvkmMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFiqqVYLASMWLA 294
Cdd:cd14967  178 LYARIFRVA------------RRELKAAKT-----LAIIVGAFLLCWLPFFIIYLVSAFCPPDCVPPI---LYAVFFWLG 237
                        250       260
                 ....*....|....*....|..
gi 568941324 295 MSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd14967  238 YLNSALNPIIYALFNRDFRRAF 259
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
63-316 1.70e-41

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 148.31  E-value: 1.70e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  63 MRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRL 142
Cdd:cd15208   31 MRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 143 SATATKVVIFVIWVLALLLAFPQGYYSTTET-MPSR------VVCMIEWPEHpnrTYEKAYHICVTVLIYFLPLLVIGYA 215
Cdd:cd15208  111 TAKRARVSILIIWIVSLLIMIPQAIVMECSRvVPLAnktillTVCDERWSDS---IYQKVYHICFFLVTYLLPLCLMILA 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 216 YTVVGITLWASEIPGDSSD--------------RYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINP-DLYLK 280
Cdd:cd15208  188 YFQIFRKLWCRQIPGTSSVvqrkwnkprksavaAEEKQLRSRRKTAKMLIVVVIMFAICYLPVHLLNILRYVFGlFTVDR 267
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568941324 281 KFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15208  268 ETIYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
54-313 3.55e-38

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 139.33  E-value: 3.55e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTY-AVHN-VWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRY 131
Cdd:cd15204   22 IAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYyVVRQrSWTHGDVLCAVVNYLRTVSLYVSTNALLVIAIDRY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 132 MAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSR--VVCMIEWPEHPNRTYeKAYHICVTVLIYFLPL 209
Cdd:cd15204  102 LVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYANQgkIFCGQIWPVDQQAYY-KAYYLFLFVLEFVLPV 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLK-KFIQQVYL 288
Cdd:cd15204  181 LIMTLCYLRIVRKVWFRRVPGQQTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYGYAIVRDFFPTLLSKeKLNTTIFY 260
                        250       260
                 ....*....|....*....|....*
gi 568941324 289 ASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15204  261 IVEALAMSNSMINTVVYVAFNNNIR 285
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
54-316 4.06e-35

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 130.66  E-value: 4.06e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFntVVNFTYAVHNV--WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRY 131
Cdd:cd14971   22 ILVVARNKPMRSTTNLFILNLAVADLTFLLF--CVPFTATIYPLpgWVFGDFMCKFVHYFQQVSMHASIFTLVAMSLDRF 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 132 MAIIHPLQPRLSATATK--VVIFVIWVLALLLAFPQGYYST--TETMPSRVVCmieWPEHPNRTYEKAYHICVTVLIYFL 207
Cdd:cd14971  100 LAVVYPLRSLHIRTPRNalAASGCIWVVSLAVAAPVLALHRlrNYTPGNRTVC---SEAWPSRAHRRAFALCTFLFGYLL 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 208 PLLVIGYAYTVVGITLWASEIPGDSSDRYHeqvSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYlkkfIQQVY 287
Cdd:cd14971  177 PLLLICVCYAAMLRHLWRVAVRPVLSEGSR---RAKRKVTRLVLVVVVLFAACWGPIHAILLLVALGPFPL----TYATY 249
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568941324 288 LASMW---LAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd14971  250 ALRIWahcLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
54-316 4.83e-35

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 130.49  E-value: 4.83e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACmaaFNTVVNFTYAVH--NVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRY 131
Cdd:cd14970   22 IYVILRYSKMKTVTNIYILNLAVADEL---FLLGLPFLATSYllGYWPFGEVMCKIVLSVDAYNMFTSIFCLTVMSVDRY 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 132 MAIIHPLQ-PRLSATA-TKVVIFVIWVLALLLAFPQGYYSTTETMPSRVV-CMIEWPEHPNrTYEKAYHICVTVLIYFLP 208
Cdd:cd14970   99 LAVVHPVKsLRFRTPRkAKLVSLCVWALSLVLGLPVIIFARTLQEEGGTIsCNLQWPDPPD-YWGRVFTIYTFVLGFAVP 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIGYAYTVVGITLWASEIPGDSSDRyhEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINpDLYLKKFIQQVYL 288
Cdd:cd14970  178 LLVITVCYSLIIRRLRSSRNLSTSGAR--EKRRARRKVTRLVLVVVAVFVVCWLPFHVFQIVRLLI-DPPETLTVVGVFL 254
                        250       260
                 ....*....|....*....|....*...
gi 568941324 289 ASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd14970  255 FCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
54-316 5.79e-35

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 130.49  E-value: 5.79e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEacMAAFNTVVNFT--YAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRY 131
Cdd:cd15096   22 ILVVLSNQQMRSTTNILILNLAVAD--LLFVVFCVPFTatDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMSLDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 132 MAIIHPLQPRLSATATKVVIFV--IWVLALLLAFP----QGYYSTTETMPSRVVCMIEWPEHPNrtyEKAYHICVTVLIY 205
Cdd:cd15096  100 LAVVHPITSMSIRTERNTLIAIvgIWIVILVANIPvlflHGVVSYGFSSEAYSYCTFLTEVGTA---AQTFFTSFFLFSY 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 206 FLPLLVIGYAYTVVGITLWASEIPGDSSDRyhEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYIN--PDLYLKKFI 283
Cdd:cd15096  177 LIPLTLICVLYMLMLRRLRRQKSPGGRRSA--ESQRGKRRVTRLVVVVVVVFAICWLPIHIILLLKYYGvlPETVLYVVI 254
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568941324 284 QqvyLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15096  255 Q---ILSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
54-313 1.49e-34

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 129.32  E-value: 1.49e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAE----ACMAAFNTVVnftYAVhNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFD 129
Cdd:cd15095   22 IYVVSRHREMRTVTNYYIVNLAVTDlaflVCCVPFTAAL---YAT-PSWVFGDFMCKFVNYMMQVTVQATCLTLTALSVD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 130 RYMAIIHPLQPRLSAT--ATKVVIFVIWVLALLLAFPQGYYSTTETMPS---RVVCMIEWPehpNRTYEKAYHICVTVLI 204
Cdd:cd15095   98 RYYAIVHPIRSLRFRTprVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWygpQTYCREVWP---SKAFQKAYMIYTVLLT 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 205 YFLPLLVIGYAYTVVGITLWASEIPGD--SSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKF 282
Cdd:cd15095  175 YVIPLAIIAVCYGLILRRLWRRSVDGNnqSEQLSERALRQKRKVTRMVIVVVVLFAICWLPNHVLNLWQRFDPNFPETYA 254
                        250       260       270
                 ....*....|....*....|....*....|.
gi 568941324 283 IQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15095  255 TYALKIAALCLSYANSAVNPFVYAFMGENFR 285
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
54-313 1.60e-33

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 126.55  E-value: 1.60e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd14969   22 IIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALAFERYLV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQP-RLSATATKVVIFVIWVLALLLAFP-----QGYysTTEtmPSRVVCMIEWPEHPNRTYekAYHICVTVLIYFL 207
Cdd:cd14969  102 IVRPLKAfRLSKRRALILIAFIWLYGLFWALPplfgwSSY--VPE--GGGTSCSVDWYSKDPNSL--SYIVSLFVFCFFL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 208 PLLVIGYAYTVVGITLWASEIPGD---SSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIq 284
Cdd:cd14969  176 PLAIIIFCYYKIYRTLRKMSKRAArrkNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTPYAVVSLYVSFGGESTIPPLL- 254
                        250       260
                 ....*....|....*....|....*....
gi 568941324 285 qVYLASMwLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd14969  255 -ATIPAL-FAKSSTIYNPIIYVFMNKQFR 281
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
54-313 1.78e-32

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 123.92  E-value: 1.78e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15927   22 ILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSIGVSVFTLTALSADRYFA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVI--FVIWVLALLLAFPQGYYSTTETM-----PSRVVCMIeWPEHPNRTYEKAyHICVTVLIYF 206
Cdd:cd15927  102 IVNPMRKHRSQATRRTLVtaASIWIVSILLAIPEAIFSHVVTFtltdnQTIQICYP-YPQELGPNYPKI-MVLLRFLVYY 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 207 L-PLLVIGYAYTVVGITLWAS--EIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLK--K 281
Cdd:cd15927  180 LiPLLIIGVFYVLMARHLIRStrNIGSGQNQAAQRQIEARKKVAKTVLAFVVLFAVCWLPRHVFMLWFHFAPNGLVDynA 259
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568941324 282 FIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15927  260 FWHVLKIVGFCLSFINSCVNPVALYLLSGSFR 291
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
38-316 2.53e-32

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 123.39  E-value: 2.53e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  38 AYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALF 117
Cdd:cd15399    6 AYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVH 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 118 ASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGY---YSTTETMP--SRVVCMIEWPEHPNRtY 192
Cdd:cd15399   86 VSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAIfreYSVIEISPdfKIQACSEKWPNGTLN-D 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 193 EKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQvsaKRKVVKMMIVVVCTFAICWLPFHIFFLLPY 272
Cdd:cd15399  165 GTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNDHYHQR---RRKTTKMLVCVVVVFAVSWLPFHAFQLASD 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568941324 273 INPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15399  242 IDSKVLDLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
56-316 1.20e-31

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 122.08  E-value: 1.20e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNV-WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAI 134
Cdd:cd14979   24 VIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYpWAFGDGGCKLYYFLFEACTYATVLTIVALSVERYVAI 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 135 IHPLQPRLSATA--TKVVIFVIWVLALLLAFPQGY--------YSTTETMPSRVVCMIEwpehPNRTYEKAYHICVTVLI 204
Cdd:cd14979  104 CHPLKAKTLVTKrrVKRFILAIWLVSILCAIPILFlmgiqylnGPLPGPVPDSAVCTLV----VDRSTFKYVFQVSTFIF 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 205 YFLPLLVIGYAYTVVGITLW------ASEIPGDSSDRYHEQ-VSAKRKVVKMMIVVVCTFAICWLPFHIFFLL-PYI-NP 275
Cdd:cd14979  180 FVLPMFVISILYFRIGVKLRsmrnikKGTRAQGTRNVELSLsQQARRQVVKMLGAVVIAFFVCWLPFHAQRLMfSYAsKE 259
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568941324 276 DLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd14979  260 DTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
30-316 1.25e-30

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 118.26  E-value: 1.25e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  30 WQIVLwaaaYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHN 109
Cdd:cd15206    2 LIIPL----YSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIP 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 110 FFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKV--VIFVIWVLALLLAFPQGYYSTTETM--PSRVVCMIEWp 185
Cdd:cd15206   78 YFQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAykVIAGIWLLSFLIMSPILVFSNLIPMsrPGGHKCREVW- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 186 ehPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWAseipgdssdryheqvsAKRKVVKMMIVVVCTFAICWLPFH 265
Cdd:cd15206  157 --PNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLLE----------------AKKRVIRMLFVIVVEFFICWTPLY 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568941324 266 IF-FLLPYINPDLYLKKF---IQQVYLasmwLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15206  219 VInTWKAFDPPSAARYVSsttISLIQL----LAYISSCVNPITYCFMNKRFRQAF 269
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
62-316 7.39e-30

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 116.75  E-value: 7.39e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  62 RMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL--- 138
Cdd:cd15098   32 KRRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRtss 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 139 QPRLSATATKVVIfVIWVLALLLAFPQGYYS---TTETMPSRVVCmieWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYA 215
Cdd:cd15098  112 SLRTRRNALLGVL-VIWVLSLAMASPVAVHQdlvHHWTASNQTFC---WENWPEKQQKPVYVVCTFVFGYLLPLLLITFC 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 216 YTVVGITLWASEIPGDSSDRyheqvSAKRKVVKMMIVVVCTFAICWLPFHI------FFLLPYINPDLYLKkfiqqvyLA 289
Cdd:cd15098  188 YAKVLNHLHKKLKNMSKKSE-----RSKKKTAQTVLVVVVVFGISWLPHHIihlwveFGDFPLTQASFVLR-------IT 255
                        250       260
                 ....*....|....*....|....*..
gi 568941324 290 SMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15098  256 AHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
33-316 8.17e-29

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 114.11  E-value: 8.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd15205    1 TAFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIF--VIWVLALLLAFPQGYYSTTETM-----PSRVVCMIEwp 185
Cdd:cd15205   81 STAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMlgLVWIVSVIVGSPMLFVQQLEVKydflyEKRHVCCLE-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 186 EHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQ-------VSAKRKVVKMMIVVVCTFA 258
Cdd:cd15205  159 RWYSPTQQKIYTTFILVILFLLPLTTMLFLYSRIGYELWIKKRVGDASVLQTIHgiemskiSRKKKRAVKMMVTVVLLFA 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 259 ICWLPFHIFFLL-PYIN-PDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15205  239 VCWAPFHVVHMMiEYSNlENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
54-313 4.85e-28

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 111.59  E-value: 4.85e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAE---ACMAAFNTVVnftYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd14982   22 LWVFLRKMKKRSPTTIYMINLALADllfVLTLPFRIYY---YLNGGWWPFGDFLCRLTGLLFYINMYGSILFLTCISVDR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQPRLSAT---ATKVVIFViWVLALLLAFPQ-GYYSTTETMPSRVVCMIEWPEHPNRTYekAYHICVTVLIYF 206
Cdd:cd14982   99 YLAVVHPLKSRRLRRkryAVGVCAGV-WILVLVASVPLlLLRSTIAKENNSTTCFEFLSEWLASAA--PIVLIALVVGFL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 207 LPLLVIGYAYTVVGITLWaseipgdSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLL-----PYINPDLYLKK 281
Cdd:cd14982  176 IPLLIILVCYSLIIRALR-------RRSKQSQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILyllvrLSFIADCSARN 248
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568941324 282 FIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd14982  249 SLYKAYRITLCLASLNSCLDPLIYYFLSKTFR 280
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
56-316 1.63e-27

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 110.46  E-value: 1.63e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAE-----ACMAAFNTVVNftyaVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd14997   24 VVWKNKDMRTPTNIFLVNLSVADllvllVCMPVALVETW----AREPWLLGEFMCKLVPFVELTVAHASVLTILAISFER 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQPRLSATA--TKVVIFVIWVLALLLAFP----QGYYSTTETMPSRV-VCMIewpeHPNRTYEKAYHICVTVL 203
Cdd:cd14997  100 YYAICHPLQAKYVCTKrrALVIIALIWLLALLTSSPvlfiTEFKEEDFNDGTPVaVCRT----PADTFWKVAYILSTIVV 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 204 IYFLPLLVIGYAYTVVGITL-WASEIP-GDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKK 281
Cdd:cd14997  176 FFVVPLAILSGLYSVICRRLvGHPALEsRRADAANRHTLRSRRQVVYMLITVVVLFFVCLLPFRVVTLWIIFAPDEDLQA 255
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568941324 282 FIQQVYLASMWLA-----MSSTMyNPIIYCCLNDRFRLGF 316
Cdd:cd14997  256 LGLEGYLNLLVFCrvmvyLNSAL-NPILYNLMSTKFRSAF 294
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
54-316 6.73e-27

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 108.13  E-value: 6.73e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15001   21 IFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICSVLTLTAISIERYYV 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATA--TKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEH--PNRTYEKAYHICVTVLIYFLPL 209
Cdd:cd15001  101 ILHPMKAKSFCTIgrARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQKawPSTLYSRLYVVYLAIVIFFIPL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVG----ITLWASEIpgdssdryheqvsakrkvvkmmivvvCTFAICWLPFHIFFLLpyINPDLYLKKFIQQ 285
Cdd:cd15001  181 IVMTFAYARDTrkqvIKMLISVV--------------------------VLFAVCWGPLLIDNLL--VSFDVISTLHTQA 232
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568941324 286 VYLASMW---LAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15001  233 LKYMRIAfhlLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
55-316 1.09e-26

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 108.44  E-value: 1.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  55 WIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAI 134
Cdd:cd15980   23 FIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSASVFTLVAIAVDRFRCI 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 135 IHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYS-TTETMPSRVV------------CMIEWpehPNRTYEKAYHICVT 201
Cdd:cd15980  103 VYPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLhVQEEKNYRVVlgsqnktspvywCREDW---PNQEMRKIYTTVLF 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 202 VLIYFLPLLVIGYAYTVVGITLWASEIPG---DSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLP-YIN-PD 276
Cdd:cd15980  180 ANIYLAPLSLIVIMYARIGITLFKTAMPHtgkHNQEQRHVVSRKKQKVIKMLLIVALLFILSWLPLWTLMMLSdYANlSP 259
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568941324 277 LYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15980  260 NQLQIINIYIYPFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
67-316 1.17e-26

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 107.99  E-value: 1.17e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  67 TNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATA 146
Cdd:cd15097   36 TNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTP 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 147 TKVV--IFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWpEHPNRtyeKAYHICVTVLIYFLPLLVIGYAYTVVGITLW 224
Cdd:cd15097  116 RNAVaaIALIWGLSLLFAGPYLSYYDLIDYANSTVCMPGW-EEARR---KAMDTCTFAFGYLIPVLVVSLSYTRTIKYLW 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 225 ASEIPGDSSDryhEQVSAKRKVVKMMIVVVCTFAICWLPFHIfFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPII 304
Cdd:cd15097  192 TAVDPLEAMS---ESKRAKRKVTKMIIIVTALFCLCWLPHHV-VILCYLYGDFPFNQATYAFRLLSHCMAYANSCLNPIV 267
                        250
                 ....*....|..
gi 568941324 305 YCCLNDRFRLGF 316
Cdd:cd15097  268 YALVSKHFRKGF 279
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
54-313 2.67e-26

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 106.91  E-value: 2.67e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAfnTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd14984   22 LLVLLYYRKLRSMTDVYLLNLALADLLFVL--TLPFWAVYAADGWVFGSFLCKLVSALYTINFYSGILFLACISIDRYLA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVI--FVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd14984  100 IVHAVSALRARTLLHGKLtcLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEDTATTWKTLLRLLQNILGFLLPLLV 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHI------FFLLPYINPDLYLKKFIQQ 285
Cdd:cd14984  180 MLFCYSRIIRTL------------LRARNHKKHRALRVIFAVVVVFFLCWLPYNIvllldtLQLLGIISRSCELSKSLDY 247
                        250       260
                 ....*....|....*....|....*...
gi 568941324 286 VYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd14984  248 ALQVTESLAFSHCCLNPVLYAFVGVKFR 275
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
54-313 3.36e-26

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 106.75  E-value: 3.36e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15397   22 ICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMSVTVSILSLVLIALERHQL 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSR------------VVCMIEWPEHPNRTyekAYHICVT 201
Cdd:cd15397  102 IINPTGWKPSVSQAYLAVVVIWMLACFISLPFLAFHILTDEPYKnlshffapladkAVCTESWPSEHHKL---AYTTWLL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 202 VLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKK 281
Cdd:cd15397  179 LFQYCLPLLFILVCYLRIYLRLRRRKDMLERRGEYNRRAGHSKRINVMLVSLVAAFALCWLPLNVFNAIADWNHEAIPHC 258
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568941324 282 FIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15397  259 QHNLIFSLCHLAAMASTCVNPIIYGFLNSNFK 290
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
54-316 9.34e-26

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 105.24  E-value: 9.34e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFA-EACMAAFNTVVNFTYAVHnvWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd15093   22 IYVVLRYAKMKTVTNIYILNLAIAdELFMLGLPFLAASNALRH--WPFGSVLCRLVLSVDGINMFTSIFCLTVMSVDRYL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPLQPR--LSATATKVVIFVIWVLALLLAFPQGYYS-TTETMPSRVVCMIEWPEhPNRTYEKAYHICVTVLIYFLPL 209
Cdd:cd15093  100 AVVHPIKSArwRRPRVAKVVNLAVWVASLLVILPVVVFAgTRENQDGSSACNMQWPE-PAAAWSAGFIIYTFVLGFLLPL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVGITLWASEIPGDSSDRYHeqvsAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPdLYLKKFIQQVYLA 289
Cdd:cd15093  179 LIICLCYLLIVIKVKSAGLRAGWQQRKR----SERKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQ-LPETPALVGVYHF 253
                        250       260
                 ....*....|....*....|....*..
gi 568941324 290 SMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15093  254 VVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
36-313 1.04e-25

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 105.67  E-value: 1.04e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  36 AAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAA 115
Cdd:cd15395    4 ALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 116 LFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYS------------TTETMPSRVVCMIE 183
Cdd:cd15395   84 ITVSIFSLVLIAIERHQLIINPRGWRPNNRHAYVGIAVIWVLAVLTSLPFLIFQvltdepfknvnvSLDAYKGKYVCLDQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 184 WPEhpnRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLP 263
Cdd:cd15395  164 FPS---DTIRLSYTTCLLVLQYFGPLCFIFICYLKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLISIVVAFAVCWLP 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 568941324 264 FHIFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15395  241 LNIFNAVFDWNHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQ 290
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
54-311 1.48e-25

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 105.20  E-value: 1.48e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15197   22 LFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVTYASTYVLVALSIDRYDA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIFVIWVLALLLAFPQG-YYSTTETMPSRVVCMIEWPEHpnrTYEKAYHICVTVLIYFLPLLVI 212
Cdd:cd15197  102 ICHPMNFSQSGRQARVLICVAWILSALFSIPMLiIFEKTGLSNGEVQCWILWPEP---WYWKVYMTIVAFLVFFIPATII 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 213 GYAYTVVGITLWA--SEIPGDSSDRYHEQVS-----------AKRKVVKMMIVVVCTFAICWLPFHIFFLL------PYI 273
Cdd:cd15197  179 SICYIIIVRTIWKksKIQVTINKAGLHDGSSrrsssrgiiprAKIKTIKMTFVIVTVFIICWSPYFVFDLLdvfgllPRS 258
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568941324 274 NPDLYLKKFIQQvylasmwLAMSSTMYNPIIYCCLNDR 311
Cdd:cd15197  259 KTKIAAATFIQS-------LAPLNSAINPLIYCLFSTH 289
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
54-313 2.79e-25

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 103.92  E-value: 2.79e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIilAHKRM-RTVTNYFLVNLAFAEACMAAFnTVVNFTY-AVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRY 131
Cdd:cd14974   22 IWV--AGFKMkRTVNTVWFLNLALADFLFCLF-LPFLIVYiAMGHHWPFGSVLCKLNSFVISLNMFASVFLLTAISLDRC 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 132 MAIIHPL--QPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHP--NRTYEKAYHICVTVLIYFL 207
Cdd:cd14974   99 LLVLHPVwaQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTCVEDYdlRRSRHKALTVIRFLCGFLL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 208 PLLVIGYAYTVVGITLwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPyINPDLYLKKFIQQVY 287
Cdd:cd14974  179 PLLIIAICYSVIAVKL------------RRKRLAKSSKPLRVLLAVVVAFFLCWLPYHVFALLE-LVAAAGLPEVVLLGL 245
                        250       260
                 ....*....|....*....|....*.
gi 568941324 288 LASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd14974  246 PLATGLAYFNSCLNPILYVFMGQDFR 271
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
56-316 4.30e-25

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 103.64  E-value: 4.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMR---TVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd15002   22 GILLNNARKgkpSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIAVLAKACYM 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPL-QPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEhPNRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15002  102 YVVNPTkQVTIKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYLCILCIPP-LAHEFMSAFVKLYPLFVFCLPLTF 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLWASEIPGDSS--DRYHEQVSakrkvvKMMIVVVCTFAICWLPFHIFFL----LPYINPDLYlkkfiQQ 285
Cdd:cd15002  181 ALFYFWRAYGQCQRRGTKTQNLrnQIRSRKLT------HMLLSVVLAFTILWLPEWVAWLwlihIKSSGSSPP-----QL 249
                        250       260       270
                 ....*....|....*....|....*....|.
gi 568941324 286 VYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15002  250 FNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
54-313 4.73e-25

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 103.61  E-value: 4.73e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd14986   22 ILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFASTYILVSMSLDRYQA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIFVIWVLALLLAFPQGY-YSTTETMPSRVVCmieWPEHPNRTYEKAYHICVTVLIYFLPLLVI 212
Cdd:cd14986  102 IVKPMSSLKPRKRARLMIVVAWVLSFLFSIPQLViFVERELGDGVHQC---WSSFYTPWQRKVYITWLATYVFVIPLIIL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 213 GYAYTVVGITLWA-----SEIPGDSSDRYHEQVS-----------AKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPD 276
Cdd:cd14986  179 SYCYGRILRTIWIrsrqkTDRPIAPTAMSCRSVScvssrvslisrAKIKTIKMTLVIILAFILCWTPYFIVQLLDVYAGM 258
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568941324 277 LYLKkfiQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd14986  259 QQLE---NDAYVVSETLASLNSALNPLIYGFFSSHLS 292
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
54-313 1.49e-24

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 102.07  E-value: 1.49e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd14985   22 VWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVISVNMFASIFLLTCMSVDRYLA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHP-----LQPRLSAtatKVVIFVIWVLALLLAFPQGYYSTTETMP--SRVVCMIEWPEHPnrtYEKAYHICVTVLIYF 206
Cdd:cd14985  102 IVHPvasrrLRRRRQA---RVTCALIWVVACLLSLPTFLLRSLQAIEnlNKTACIMLYPHEA---WHFGLSLELNILGFV 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 207 LPLLVIGYAYTVVGITLWASEipgdssDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIF-FL-----LPYINPDLYLk 280
Cdd:cd14985  176 LPLLIILTCYFHIARSLRKRY------ERTGKNGRKRRKSLKIIFALVVAFLVCWLPFHFFkFLdflaqLGAIRPCFWE- 248
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568941324 281 KFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd14985  249 LFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFR 281
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
54-316 6.76e-24

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 100.26  E-value: 6.76e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACmaaFNTVVNFtYAVHNV---WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15974   22 IYVVLRYAKMKTVTNIYILNLAVADEL---FMLGLPF-LATQNAisyWPFGSFLCRLVMTVDGVNQFTSIFCLTVMSIDR 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPL------QPRLSatatKVVIFVIWVLALLLAFPQGYYSttETMPSRVVCMIEWPEhPNRTYEKAYHICVTVLI 204
Cdd:cd15974   98 YLAVVHPIkstkwrRPRVA----KLINATVWTLSFLVVLPVIIFS--DVQPDLNTCNISWPE-PVSVWSTAFIIYTAVLG 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 205 YFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIvvvcTFAICWLPFHIF--FLLPYINPDlylKKF 282
Cdd:cd15974  171 FFGPLLVICLCYLLIVIKVKSSGLRVGSTKRRKSERKVTRMVVIIVV----VFVFCWLPFYMLniVNLIVILPE---EPA 243
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568941324 283 IQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15974  244 FVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
54-313 2.79e-23

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 98.29  E-value: 2.79e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15088   22 LYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALDANNQFTSTYILTAMSVDRYLA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSAT--ATKVVIFVIWVLALLLAFPQGYYSTTETMP-SRVVCMIEWPEhPNRTYekAYHICVTVLIYFLPLL 210
Cdd:cd15088  102 VVHPIRSTKYRTrfVAKLVNVGLWAASFLSILPVWVYSSLIYFPdGTTFCYVSLPS-PDDLY--WFTIYHFILGFAVPLV 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVvvctFAICWLPFHIFFLLpYINPDLYLKKFIqQVYLAS 290
Cdd:cd15088  179 VITVCYILILHRLARGVAPGNQSHGSSRTKRVTKMVILIVVV----FIVCWLPFHVVQLV-NLAMNRPTLAFE-VAYFLS 252
                        250       260
                 ....*....|....*....|...
gi 568941324 291 MWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15088  253 ICLGYANSCLNPFVYILVSENFR 275
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
54-313 3.06e-23

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 98.54  E-value: 3.06e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15168   22 LYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRFLFYFNLYGSILFLTCISVHRYLG 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPR--LSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMiEWPEHPNRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15168  102 ICHPLRSLgkLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCY-DTTSPEELNDYVIYSMVLTGLGFLLPLLI 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLWaseipgdSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHI---FFLLPYINPDLYLKKFIQQVYL 288
Cdd:cd15168  181 ILACYGLIVRALI-------RKLGEGVTSALRRKSIRLVIIVLALFAVCFLPFHVtrtINLAARLLSGTASCATLNGIYV 253
                        250       260
                 ....*....|....*....|....*...
gi 568941324 289 A---SMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15168  254 AykvTRPLASLNSCLNPLLYFLAGDKFR 281
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
54-313 3.84e-23

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 98.12  E-value: 3.84e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15074   22 LFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLTAISIYRYLK 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHP-LQPRLSATATKVVIFVIWVLALLLAFPQ----GYYsTTEtmPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLP 208
Cdd:cd15074  102 ICHPpYGPKLSRRHVCIVIVAIWLYALFWAVAPlvgwGSY-GPE--PFGTSCSIDWTGASASVGGMSYIISIFIFCYLLP 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIGYAYTVVGITLWAS--EIPGDSSDRYHEQvSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKkfIQQV 286
Cdd:cd15074  179 VLIIVFSYVKIIRKVKSSrkRVAGFDSRSKRQH-KIERKVTKVAVLICAGFLIAWTPYAVVSMWSAFGSPDSVP--ILAS 255
                        250       260
                 ....*....|....*....|....*..
gi 568941324 287 YLASMwLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15074  256 ILPAL-FAKSSCMYNPIIYLLFSSKFR 281
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
34-313 6.15e-23

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 97.51  E-value: 6.15e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  34 LWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPI 113
Cdd:cd15012    1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 114 AALFASIYSMTAVAFDRYMAIIHPLQPR--LSATATKVVIFVIWVLALLLAFPQGYYSTTETM--PSRVVCMIEWPEHPN 189
Cdd:cd15012   81 LSYTASIGILVVISVERYIAILHPLRCKqlLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEIlvTQDGQEEEICVLDRE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 190 RTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASeipgdssdryhEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFL 269
Cdd:cd15012  161 MFNSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKS-----------SSIEARRKVVRLLVAVVVSFALCNLPYHARKM 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 568941324 270 LPYI-NPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15012  230 WQYWsEPYRCDSNWNALLTPLTFLVLYFNSAVNPLLYAFLSKRFR 274
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
54-316 8.34e-23

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 97.16  E-value: 8.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNvWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15094   22 IYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKY-WPFGAAMCKIYMVLTSINQFTSSFTLTVMSADRYLA 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQ-PRL-SATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15094  101 VCHPIRsMRYrTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDSSAVNGQKAFTLYTFLLGFAIPLLL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLWASEIPGDSSdryhEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFL-LPYINPDLYLKKFIQQVYLAS 290
Cdd:cd15094  181 ISVFYTLVILRLRTVGPKNKSK----EKRRSHRKVTRLVLTVISVYIICWLPYWAFQVhLIFLPPGTDMPKWEILMFLLL 256
                        250       260
                 ....*....|....*....|....*.
gi 568941324 291 MWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15094  257 TVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
54-316 2.68e-22

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 95.68  E-value: 2.68e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFA-EACMAAFNTVVNFTYAVHnvWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd15971   22 IYVILRYAKMKTVTNIYILNLAIAdELFMLGLPFLAIQVALVH--WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPLQP---RLSATAtKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEhPNRTYEKAYHICVTVLIYFLPL 209
Cdd:cd15971  100 AVVHPIKSakwRKPRTA-KMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIWPG-ESSAWYTGFIIYTFILGFFVPL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIvvvcTFAICWLPFHIFFLLPY---INPDLYLKKFIQQV 286
Cdd:cd15971  178 TIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVA----VFVFCWLPFYIFNVSSVsvsISPTPGLKGMFDFV 253
                        250       260       270
                 ....*....|....*....|....*....|
gi 568941324 287 YLasmwLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15971  254 VV----LSYANSCANPILYAFLSDNFKKSF 279
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
54-316 2.71e-22

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 95.69  E-value: 2.71e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNvWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15973   22 IFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQH-WPFGSAMCRTVLSVDGINMFTSVFCLTVLSVDRYIA 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRL--SATATKVVIFVIWVLALLLAFPQGYYSTTETMPSR-VVCMIEWPeHPnrTYEKAYHICVTVLIYFLPLL 210
Cdd:cd15973  101 VVHPLRAARyrRPTVAKMINICVWILSLLVISPIIIFADTATRKGQaVACNLIWP-HP--AWSAAFVIYTFLLGFLLPVL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIvvvcTFAICWLPFHIFFLLpyinpDLYLKKFIQQVYLAS 290
Cdd:cd15973  178 AIGLCYILIIGKMRAVALKAGWQQRRKSEKKITRMVLMVVT----VFVICWMPFYVVQLL-----NLFLPRLDATVNHAS 248
                        250       260
                 ....*....|....*....|....*.
gi 568941324 291 MWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15973  249 LILSYANSCANPILYGFLSDNFRRSF 274
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
36-316 3.98e-22

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 95.31  E-value: 3.98e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  36 AAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNftyaVHNVW-----YYGLFYCKFHNF 110
Cdd:cd15357    4 SLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLE----VYEMWsnypfLFGPVGCYFKTA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 111 FPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKV--VIFVIWVLALLLAFP--------QGYYSTTETMPSRVVC 180
Cdd:cd15357   80 LFETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERAlkIIVVLWVLSVLFSIPntsihgikLQYFPNGTLIPDSATC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 181 MIewpEHPNRTYEKAYHIcVTVLIYFLPLLVIGYAYTVVGITLwaseiPGDSSDRYHE-----QVSAKRKVVKMMIVVVC 255
Cdd:cd15357  160 TV---VKPLWIYNLIIQI-TSLLFYVLPMGVISVLYYLMGLKL-----RGDKSLEADEmnvniQRPSRKSVTKMLFVLVL 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568941324 256 TFAICWLPFHI-----FFLLPYINPdlyLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15357  231 VFAICWAPFHVdrlffSFVVEWTEP---LANVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
36-316 4.67e-22

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 95.35  E-value: 4.67e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  36 AAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAA 115
Cdd:cd15124    4 PTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLTS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 116 LFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVI--FVIWVLALLLAFPQGYYS------TTETMPSRVVCMiEWPeH 187
Cdd:cd15124   84 VGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLkaALIWILSMLLAIPEAVFSdlhpfyDKSTNKTFVSCA-PYP-H 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 188 PNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLW--ASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFH 265
Cdd:cd15124  162 SNELHPKIHSMASFLIFYVIPLSIISVYYYFIAKNLIrsAYNLPVEGNVHVRRQIESRKRLAKTVLVFVGLFAFCWLPNH 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568941324 266 IFFLLP---YINPDLYLKKFIQQVylASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15124  242 IIYLYRsyhYSEVDTSMLHFVSSI--CARILAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
54-316 4.68e-22

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 94.35  E-value: 4.68e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILA---HKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15061   18 LLVILAvatTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLCTASILNLCCISLDR 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQ--PRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIewpehpnrTYEKAYHICVTVLIYFLP 208
Cdd:cd15061   98 YFAITYPLKyrTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCYY--------TYDKGYRIYSSMGSFFLP 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIGYAYTvvgitlwaseipgdssdRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPdlylKKFIQQVYL 288
Cdd:cd15061  170 LLLMLFVYL-----------------RIFRVIAKERKTAKTLAIVVGCFIVCWLPFFIMYLIEPFCD----CQFSEALST 228
                        250       260
                 ....*....|....*....|....*...
gi 568941324 289 ASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15061  229 AFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
33-316 5.16e-22

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 95.28  E-value: 5.16e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd15981    1 AMFILAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVV------------C 180
Cdd:cd15981   81 GMSVSASVFTLVAIAVERFRCIVHPFRQKLTLRKAIVTIVIIWVLALIIMCPSAVTLTVTREEHHFMvddynnsyplysC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 181 MIEWPEHPNRtyeKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIP--GDSSDRYHEQVSAKRKVVKMMIVVVCT-- 256
Cdd:cd15981  161 WEAWPDTEMR---KIYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPirGSQGEEEEGRRVSKRKIKVINMLIIVAlf 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568941324 257 FAICWLPFHIFFLLP-YINPDLY-LKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15981  238 FTLSWLPLWTLMLLTdYGHLSEDqLNLVTVYVFPFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
39-316 6.12e-22

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 94.59  E-value: 6.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  39 YTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFA-EACMAAFNTVVNFTYAVHnvWYYGLFYCKFHNFFPIAALF 117
Cdd:cd15970    7 YSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIAdELLMLSVPFLVTSTLLRH--WPFGSLLCRLVLSVDAINMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 118 ASIYSMTAVAFDRYMAIIHPLQPR--LSATATKVVIFVIWVLALLLAFPQGYYSTTETMPS-RVVCMIEWPEhPNRTYEK 194
Cdd:cd15970   85 TSIYCLTVLSIDRYIAVVHPIKAAryRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDgSVACNMQMPE-PSQRWLA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 195 AYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLpyin 274
Cdd:cd15970  164 VFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKAG----WQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLV---- 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568941324 275 pDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15970  236 -SVFVGQHDATVSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
39-316 9.75e-22

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 94.60  E-value: 9.75e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  39 YTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFA 118
Cdd:cd15123    7 YAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 119 SIYSMTAVAFDRYMAIIHPLQPRLSATATKVVI--FVIWVLALLLAFPQGYYSTTETM--PSRVVCMIEWPEHP--NRTY 192
Cdd:cd15123   87 SVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCkaGCVWIVSMLFAIPEAVFSDLYSFrdPEKNTTFEACAPYPvsEKIL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 193 EKAYHICVTVLIYFLPLLVIGYAYTVVGITLWAS--EIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLL 270
Cdd:cd15123  167 QEIHSLLCFLVFYIIPLSIISVYYFLIARTLYKStfNMPAEEHSHARKQIESRKRVAKTVLVLVALFAFCWLPNHILYLY 246
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568941324 271 ------PYINPDLYlkKFIQQVYlaSMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15123  247 rsftyhTSVDSSAF--HLIATIF--SRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
54-313 9.94e-22

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 94.15  E-value: 9.94e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15085   22 IAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWSLTLLAYERYNV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQP-RLSATATKVVIFVIWVLALLLAF-PQGYYSTTETMPSRVVCMIEWPEHPNRTYekAYHICVTVLIYFLPLLV 211
Cdd:cd15085  102 VCKPMGGlKLSTKRGYQGLLFIWLFCLFWAVaPLFGWSSYGPEGVQTSCSIGWEERSWSNY--SYLILYFLMCFVIPVAI 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLWA-----SEIPGDSSDRYHEQVsakrkvVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQV 286
Cdd:cd15085  180 IGFSYGNVLRSLHKlnkkiEQQGGKNCPEEEERA------VIMVLAMVIAFLICWLPYTVFALIVVVNPELSISPLAATM 253
                        250       260
                 ....*....|....*....|....*..
gi 568941324 287 ylaSMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15085  254 ---PTYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
56-316 1.60e-21

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 93.93  E-value: 1.60e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMaafnTVVNFTYAVHNVWYY-----GLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15134   24 VIARNRSMHTATNYYLFSLAVSDLLL----LILGLPFELYTIWQQypwvfGEVFCKLRAFLSEMSSYASVLTITAFSVER 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQPRLSATATKVV--IFVIWVLALLLAFPQGYYSTTEtmpsrvvcMIEWPEHPNRTYEKAYhICV-------- 200
Cdd:cd15134  100 YLAICHPLRSHTMSKLSRAIriIIAIWIIAFVCALPFAIQTRIV--------YLEYPPTSGEALEESA-FCAmlneippi 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 201 -------TVLIYFLPLLVIGYAYTVVGITLWASEI---PGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLL 270
Cdd:cd15134  171 tpvfqlsTFLFFIIPMIAIIVLYVLIGLQLRRSTLlrrGQRSVSGGRRSSQSRRTVLRMLVAVVVAFFICWAPFHAQRLL 250
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568941324 271 P-YI-NPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15134  251 TvYAkNMTPPYLFINRILFYISGVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
54-316 2.31e-21

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 93.26  E-value: 2.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15000   21 LYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVLALCAVSYDRLTA 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYST---------TETM--PSRVVCMIEWpehpnrtyekayHICVTV 202
Cdd:cd15000  101 IVLPSEARLTKRGAKIVIVITWIVGLLLALPLAIYRSyrerqwknfLETYcaENTQVLPIYW------------HVIITV 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 203 LIYfLPLLVIGYAYTVVGITLWASEiPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYIN-PDLYLKK 281
Cdd:cd15000  169 LVW-LPLGIMLICYSAIFWKLDKYE-RRVLRREHPSVVRYKKKAAKTLFIVLITFVVCRIPFTALIFYRYKLvPNDNTQN 246
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568941324 282 FIQQVYLaSMWLAMSSTMY-----NPIIYCCLNDRFRLGF 316
Cdd:cd15000  247 SVSGSFH-ILWFASKYLMFlnaavNPLIYGFTNENFRKAF 285
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
56-316 2.93e-21

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 92.98  E-value: 2.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNV-WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAI 134
Cdd:cd15133   24 VIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNYpFLLGSGGCYFKTFLFETVCLASILNVTALSVERYIAV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 135 IHPLQPRLSATATKV--VIFVIWVLALLLAFP----QGYYSTTETMPSRVVCMIEWPehpnrtyEKAYHICV---TVLIY 205
Cdd:cd15133  104 VHPLAARTCSTRPRVtrVLGCVWGVSMLCALPntslHGIKFLGSGVPASAQCTVRKP-------QAIYNMIPqhtGHLFF 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 206 FLPLLVIGYAYTVVGITL---------WASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPD 276
Cdd:cd15133  177 VLPMAVISVLYLLMALRLarergldatGAGSKIGTRTGQLLQHPRTRAQVTKMLFILVVVFAICWAPFHIDRLMWSFISD 256
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568941324 277 LY--LKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15133  257 WTdnLHEVFQYVHIISGVFFYLSSAVNPILYNLMSTRFREMF 298
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
63-313 3.37e-21

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 92.94  E-value: 3.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  63 MRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRL 142
Cdd:cd15928   31 MRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCTYASILHITALSVERYLAICHPLRAKV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 143 SATA--TKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCM-IEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVV 219
Cdd:cd15928  111 LVTRgrVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRgFECTVVNVSSGLLSVMLWVSTSFFFVPMVCLSLLYGLI 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 220 GITLWASEIPGDSSDRYHEQVSaKRKVVKMMIVVVCTFAICWLPFHIFFLLpYIN---PDLYLKKFIQQVYLASMWLAMS 296
Cdd:cd15928  191 GRALWDRRQRSRTAGASRRDNN-HRQTVRMLAVIVLAFVLCWLPFHVGRVI-FNHsraSTKHLHYVSQYFNLVSFVLFYL 268
                        250
                 ....*....|....*..
gi 568941324 297 STMYNPIIYCCLNDRFR 313
Cdd:cd15928  269 SAAINPILYNLMSKRYR 285
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
54-316 4.88e-21

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 92.66  E-value: 4.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15958   22 IVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTASIETLCVIAIDRYLA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPL--QPRLSATATKVVIFVIWVLALLLAF-PQGYYSTTETMPSRVVCMiEWPEHPNRTYEKAYHICVTVLIYFLPLL 210
Cdd:cd15958  102 ITSPFryQSLLTRARAKGIVCTVWAISALVSFlPIMMHWWRDEDDQALKCY-EDPGCCDFVTNRAYAIASSIISFYIPLL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVV---------------GITLWASEIPGDSSDRYHEQVSAKRKVVKMMI--VVVCTFAICWLPFHIFFLLPYI 273
Cdd:cd15958  181 IMIFVYLRVyreakkqikkidkceGRFHNTLTGLGRKCKRRPSRILALREQKALKTlgIIMGVFTLCWLPFFLVNVVNVF 260
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568941324 274 NPDLYLKKfiqqVYLASMWLAMSSTMYNPIIYCCLNDrFRLGF 316
Cdd:cd15958  261 NRELVPDW----LFVFFNWLGYANSAFNPIIYCRSPD-FRKAF 298
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
54-313 5.42e-21

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 92.17  E-value: 5.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15132   22 VLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYRLWKSRPWIFGEFLCRLYHYISEGCTYATILHITALSIERYLA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKV--VIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNrtyEKAYH-------ICVTVLI 204
Cdd:cd15132  102 ICFPLRAKVLVTRRRVkcVIAALWAFALLSAGPFLFLVGVEQDNNIHPDDFSRECKHT---PYAVSsgllgimIWVTTTY 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 205 YFLPLLVIGYAYTVVGITLWASE--IPGDSS---DRYHEQVsakrkvVKMMIVVVCTFAICWLPFHIFFLLpYINPDLY- 278
Cdd:cd15132  179 FFLPMLCLSFLYGFIGRKLWKSKndLRGPNAaarERSHRQT------VRILAVVVLAFIICWLPFHIGRIL-FANTEDYr 251
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568941324 279 LKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15132  252 TMMFSQYFNIVAMQLFYLSASINPILYNLISRKYR 286
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
33-316 5.44e-21

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 91.94  E-value: 5.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVhNVWYYGLFYCKFHNFFP 112
Cdd:cd15091    1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLM-NSWPFGDVLCKIVISID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQPRLSAT--ATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVV--CMIEWPEHP 188
Cdd:cd15091   80 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTplKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSteCSLQFPDDD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 189 NRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIpgdsSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFF 268
Cdd:cd15091  160 YSWWDTFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRL----LSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFI 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568941324 269 LLPYINpDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15091  236 LVEALG-SVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
56-316 6.08e-21

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 92.10  E-value: 6.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:cd14977   24 IVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSLGVTVFSLCALSIDRYRAAV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 --HPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSR-----VVCMIEWPEHPNRTYEKAyHICVTVLIYF-L 207
Cdd:cd14977  104 nsMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVARESSLdnsslTVCIMKPSTPFAETYPKA-RSWWLFGCYFcL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 208 PLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSaKRKVVKMMIVVVCtFAICWLPFHIFFLLPYINP---DLYLKKFIQ 284
Cdd:cd14977  183 PLAFTAVCYLLMARTLIRAAKEYTRGTKKHMKQR-RQLAKTVLCLVLV-FAFCWLPEHISNILRATLYnevLIDTRSTLD 260
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568941324 285 QVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd14977  261 ILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
56-313 7.73e-21

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 91.93  E-value: 7.73e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAE--ACMAAFNTVVNFTYAVHNVWYYG---LFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd14978   23 VVLTRKSMRSSTNVYLAALAVSDilVLLSALPLFLLPYIADYSSSFLSyfyAYFLPYIYPLANTFQTASVWLTVALTVER 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQPRLSATA--TKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPN-----RTYEKAYHICVTVL 203
Cdd:cd14978  103 YIAVCHPLKARTWCTPrrARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLlrqneTYLLKYYFWLYAIF 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 204 IYFLPLLVIGYAYTVVGITLWASE----IPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYL 279
Cdd:cd14978  183 VVLLPFILLLILNILLIRALRKSKkrrrLLRRRRRLLSRSQRRERRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFL 262
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568941324 280 KKFIQQ-VYLASMwLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd14978  263 SPIYQLlGDISNL-LVVLNSAVNFIIYCLFSSKFR 296
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
38-313 8.50e-21

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 91.82  E-value: 8.50e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  38 AYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALF 117
Cdd:cd15396    6 AYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 118 ASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFP------------QGYYSTTETMPSRVVCMIEWP 185
Cdd:cd15396   86 VSIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVLIWLFSLMISIPflifhqltdepfRNLSSHSDFYKDKVVCIEAWP 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 186 EHPNRTyekAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFH 265
Cdd:cd15396  166 SETERL---IFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNSKIDRMRENESRLSENKRINTMLISIVVTFAACWLPLN 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568941324 266 IFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15396  243 IFNVVFDWNHEVLMSCHHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQ 290
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
37-316 1.21e-20

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 91.17  E-value: 1.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  37 AAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYaVHNVWYYGLFYCKFHNFFPIAAL 116
Cdd:cd15089    5 ALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKY-LMETWPFGELLCKAVLSIDYYNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 117 FASIYSMTAVAFDRYMAIIHPLQP---RLSATAtKVVIFVIWVLALLLAFPQGYYSTTETMPS-RVVCMIEWPEhPNRTY 192
Cdd:cd15089   84 FTSIFTLTMMSVDRYIAVCHPVKAldfRTPAKA-KLINICIWVLSSGVGVPIMVMAVTKTPRDgAVVCMLQFPS-PSWYW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 193 EKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSsdryHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPY 272
Cdd:cd15089  162 DTVTKICVFIFAFVVPILVITVCYGLMILRLRSVRLLSGS----KEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIVWT 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568941324 273 INPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15089  238 LVDIDRRNPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
56-316 2.32e-20

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 90.60  E-value: 2.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMaafnTVVNFTYAVHNVWY-----YGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15358   24 VILRHKVMRTPTNYYLFSLAVSDLLV----LLLGMPLELYEMWSnypflLGAGGCYFKTLLFETVCFASILNVTALSVER 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQPRLSATAT--KVVIFVIWVLALLLAFP--------QGYYSTTETMPSRVVCMiewPEHPNRTYEKAYHIcV 200
Cdd:cd15358  100 YIAVVHPLKAKYVVTRThaKRVIGAVWVVSILCSIPntslhgifQLTVPCRGPVPDSATCM---LVKPRWMYNLIIQI-T 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 201 TVLIYFLPLLVIGYAYTVVGITL------------WASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFF 268
Cdd:cd15358  176 TLLFFFLPMGTISVLYLLIGLQLkrekmllvleakGSKAGDSYQHRRIQQEKRRRRQVTKMLFVLVVVFGICWAPFHTDR 255
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 568941324 269 LLPYI--NPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15358  256 LMWSFisQWTGELHLAFQYVHIISGVFFYLSSAANPVLYNLMSTRFREMF 305
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
57-316 2.93e-20

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 90.08  E-value: 2.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15051   25 VAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASILNLFAISLDRYLAITA 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PL--QPRLSATATKVVIFVIWVLALLLAF---PQGYYS---TTETMPSRVVCMIEWpehpNRTYEkayhICVTVLIYFLP 208
Cdd:cd15051  105 PLryPSRVTPRRVAIALAAIWVVSLAVSFlpiHLGWNTpdgRVQNGDTPNQCRFEL----NPPYV----LLVAIGTFYLP 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIGYAYTvvGITLWASE--------IPGDSSDRYHEQVSAK-RKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDlyl 279
Cdd:cd15051  177 LLIMCGVYL--RIFRIAREqakrinalTPASTANSSKSAATAReHKATVTLAAVLGAFIICWFPYFTYFTYRGLCGD--- 251
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568941324 280 kKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15051  252 -NINETALSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
37-313 4.44e-20

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 89.42  E-value: 4.44e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  37 AAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAAL 116
Cdd:cd15191    5 VLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLTLNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 117 FASIYSMTAVAFDRYMAIIHPL--QPRLSATATKVVIFViWVLALLLAFPQGYYSTTETMPSRVV--CMIEWPEHPNRTY 192
Cdd:cd15191   85 FASIFFITCMSVDRYLAVVYPLrsQRRRSWQARLVCLLV-WVLACLSSLPTFYFRDTYYIEELGVnaCIMAFPNEKYAQW 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 193 EKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRyHEQVsakrkvVKMMIVVVCTFAICWLPFHIFFLLP- 271
Cdd:cd15191  164 SAGLALMKNTLGFLIPLIVIATCYFGIGRHLLKTKGFGKNKQR-RDKV------LKMVAAVVLAFLICWFPFHVLTFLDa 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 568941324 272 ----YINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15191  237 larmGVINNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFR 282
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
54-313 4.80e-20

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 89.69  E-value: 4.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFN-----TVVNFtyavHNVWYYGLFYCKFHNFfpIAALFA--SIYSMTAV 126
Cdd:cd15337   22 IYLFSKTKSLRTPSNMFIINLAISDFGFSAVNgfplkTISSF----NKKWIWGKVACELYGF--AGGIFGfmSITTLAAI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 127 AFDRYMAIIHPLQPRLSATATK--VVIFVIWVLALLLAFP----------QGYYST------TETMPSRvvcmiewpehp 188
Cdd:cd15337   96 SIDRYLVIAKPLEAMKKMTFKRafIMIIIIWLWSLLWSIPpffgwgryvpEGFQTSctfdylSRDLNNR----------- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 189 nrtyekAYHICVTVLIYFLPLLVIGYAYtvVGI---------TLWASEIPGDSSDRYHEQVSAKR--KVVKMMIVVVCTF 257
Cdd:cd15337  165 ------LFILGLFIFGFLCPLLIIIFCY--VNIiravrnhekEMTQTAKSGMGKDTEKNDARKKAeiRIAKVAIILISLF 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568941324 258 AICWLPFHIFFLLPYINPDLYLKKFIQQVylaSMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15337  237 LLSWTPYAVVALLGQFGPAYWITPYVSEL---PVMFAKASAIYNPIIYALSHPKFR 289
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
54-313 6.96e-20

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 88.68  E-value: 6.96e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15209   22 ILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIFNITAIAINRYCY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQ-PRL-SATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIewpehpNRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15209  102 ICHSLQyDRLySLRNTCCYLCLTWLLTVLAVLPNFFIGSLQYDPRIYSCTF------AQTVSTVYTITVVVIHFLLPLLI 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVcTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLASM 291
Cdd:cd15209  176 VSFCYLRIWVLVLQVRQRVKPDQRPKLKPADVRNFLTMFVVFV-LFAVCWAPLNFIGLAVAINPKEMAPKIPEWLFVASY 254
                        250       260
                 ....*....|....*....|..
gi 568941324 292 WLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15209  255 FMAYFNSCLNAIIYGLLNQNFR 276
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
54-316 7.55e-20

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 88.71  E-value: 7.55e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEAC-------MAAFNTVvnftyavhNVWYYGLFYCKFHNFFPIAALFASIYSMTAV 126
Cdd:cd15972   22 IYVVLRYSASESVTNIYILNLALADELfmlglpfLAAQNAL--------SYWPFGSFMCRLVMTVDAINQFTSIFCLTVM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 127 AFDRYMAIIHPLQPR--LSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSrvVCMIEWPEhPNRTYEKAYHICVTVLI 204
Cdd:cd15972   94 SVDRYLAVVHPIRSSkwRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMG--TCHIAWPE-PAQVWRAGFIIYTATLG 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 205 YFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQvsAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPdLYLKKFIQ 284
Cdd:cd15972  171 FFCPLLVICLCYLLIVVKVRSSGRRVRATSTKRRG--SERKVTRMVVIVVAAFVLCWLPFYALNIVNLVCP-LPEEPSLF 247
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568941324 285 QVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15972  248 GLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
54-316 8.19e-20

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 88.99  E-value: 8.19e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15195   22 LIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLSSFMLVVIALDRVFA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSR---VVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLL 210
Cdd:cd15195  102 ILSPLSANQARKRVKIMLTVAWVLSALCSIPQSFIFSVLRKMPEqpgFHQCVDFGSAPTKKQERLYYFFTMILSFVIPLI 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLW-------ASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKkfI 283
Cdd:cd15195  182 ITVTCYLLILFEISkmakrarDTPISNRRRSRTNSLERARMRTLRMTALIVLTFIVCWGPYYVLGLWYWFDKESIKN--L 259
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568941324 284 QQVYLASMWLAM-SSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15195  260 PPALSHIMFLLGyLNPCLHPIIYGVFMKEIRNWI 293
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
37-316 9.28e-20

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 88.51  E-value: 9.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  37 AAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYaVHNVWYYGLFYCKFHNFFPIAAL 116
Cdd:cd15090    5 ALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNY-LMGTWPFGNILCKIVISIDYYNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 117 FASIYSMTAVAFDRYMAIIHPLQPRLSATA--TKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPeHPNRTYEK 194
Cdd:cd15090   84 FTSIFTLCTMSVDRYIAVCHPVKALDFRTPrnAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFS-HPSWYWEN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 195 AYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSsdryHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYIN 274
Cdd:cd15090  163 LLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGS----KEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALV 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568941324 275 --PDLYLKKFIQQVYLAsmwLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15090  239 tiPETTFQTVSWHFCIA---LGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
33-316 1.05e-19

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 88.71  E-value: 1.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTV--TNYFLVNLAFAE---ACMAAFNTVvnfTYAVHNVWYYGLFYCKF 107
Cdd:cd14976    1 NLVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQQseSNKFVFNLALTDlifVLTLPFWAV---EYALDFVWPFGTAMCKV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 108 HNFFPIAALFASIYSMTAVAFDRYMAIIHPLQP--RLSATATKVVIFVIWVLALLLAFPQGYYSTT--ETMPSRvVCMIE 183
Cdd:cd14976   78 VRYVTKLNMYSSIFFLTALSVTRYIAVARALKHgwIRKAFGAFATTIAIWAAAALAAIPEAIFSTDtwSSVNHT-LCLLR 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 184 WPEHPN----RTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLwaSEIPGDSSDRyheqvsaKRKVVKMMIVVVCTFAI 259
Cdd:cd14976  157 FPKNSSvtrwYNWLGMYQLQKVVLGFFLPLGIITLSYLLLLRFL--QRKRGGSKRR-------KSRVTKSVFIVVLSFFI 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568941324 260 CWLPFHIF--------FLLPYINPDLYLkkFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd14976  228 CWLPNQALslwsalikFDDVPFSDAFFA--FQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
62-316 1.52e-19

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 88.28  E-value: 1.52e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  62 RMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL--Q 139
Cdd:cd15058   30 RLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITRPLryQ 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 140 PRLSATATKVVIFVIWVLALLLAF-P--QGYYSTTEtmPSRVVCMiEWPE----HPNRtyekAYHICVTVLIYFLPLLVI 212
Cdd:cd15058  110 VLLTKRRARVIVCVVWIVSALVSFvPimNQWWRAND--PEANDCY-QDPTccdfRTNM----AYAIASSVVSFYIPLLIM 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 213 GYAYTVV-GITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVC-----------------------TFAICWLPFHIFF 268
Cdd:cd15058  183 IFVYARVfLIATRQLQLIDKRRLRFQSECPAPQTTSPEGKRSSGrrpsrltvvkehkalktlgiimgTFTLCWLPFFIAN 262
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568941324 269 LLPYINPDLylkkFIQQVYLASMWLAMSSTMYNPIIYCCLNDrFRLGF 316
Cdd:cd15058  263 IINVFNRNL----PPGEVFLLLNWLGYINSGLNPIIYCRSPE-FRTAF 305
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
54-316 1.62e-19

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 88.38  E-value: 1.62e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAfnTVVNF--TYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRY 131
Cdd:cd15957   22 ITAIAKFERLQTVTNYFITSLACADLVMGL--AVVPFgaAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 132 MAIIHPL--QPRLSATATKVVIFVIWVLALLLAF-PQGYYSTTETMPSRVVCMIEwPEHPNRTYEKAYHICVTVLIYFLP 208
Cdd:cd15957  100 FAITSPFkyQSLLTKNKARVIILMVWIVSGLTSFlPIQMHWYRATHQEAINCYAE-ETCCDFFTNQAYAIASSIVSFYVP 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIGYAYT-VVGITLWASEIPGDSSDRYHEQVSAKRKVV----KMMIVVVC---------------TFAICWLPFHIFF 268
Cdd:cd15957  179 LVIMVFVYSrVFQEAKRQLQKIDKSEGRFHNQNIDQNGSGggggNRRRSKFClkehkalktlgiimgTFTLCWLPFFIVN 258
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568941324 269 LLPYINPDLYLKKfiqqVYLASMWLAMSSTMYNPIIYCCLNDrFRLGF 316
Cdd:cd15957  259 IVHVIQDNLIRKE----VYILLNWIGYVNSGFNPLIYCRSPD-FRIAF 301
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
57-316 3.41e-19

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 86.64  E-value: 3.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFntVVNFT---YAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15067   24 VLRERYLRTVTNYFIVSLAVADLLVGSI--VMPFSilhEMTGGYWLFGRDWCDVWHSFDVLASTASILNLCVISLDRYWA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPL--QPRLSATATKVVIFVIWVLALLLAFPQ--GYYSTTETMPSRVVCMIewpehpnrTYEKAYHICVTVLIYFLPL 209
Cdd:cd15067  102 ITDPIsyPSRMTKRRALIMIALVWICSALISFPAiaWWRAVDPGPSPPNQCLF--------TDDSGYLIFSSCVSFYIPL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVGITlwASeipgdssdryHEQVSAKrkvvkMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFiQQVYLA 289
Cdd:cd15067  174 VVMLFTYYRIYRA--AA----------KEQKAAK-----TLGIVMGVFILCWLPFFVTNILIGFCPSNCVSNP-DILFPL 235
                        250       260
                 ....*....|....*....|....*..
gi 568941324 290 SMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15067  236 VTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
57-316 3.66e-19

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 86.33  E-value: 3.66e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15060   25 VFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCTASILNLCAIALDRYWAIHD 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPRLSATATKV--VIFVIWVLALLLAFPQgyysttetmpsrVVCMIEWPEHPNR------TYEKAYHICVTVLIYFLP 208
Cdd:cd15060  105 PINYAQKRTLKRVllMIVVVWALSALISVPP------------LIGWNDWPENFTEttpctlTEEKGYVIYSSSGSFFIP 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIGYAYTVVGITlwaseipgdssdryheqVSAKRKVVKMMIVVVCTFAICWLPFHIFF-LLPY---INPDLYLKKFIq 284
Cdd:cd15060  173 LLIMTIVYVKIFIA-----------------TSKERRAARTLGIIMGVFVVCWLPFFLMYvILPFcetCSPSAKVVNFI- 234
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568941324 285 qvylasMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15060  235 ------TWLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
39-316 3.88e-19

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 86.79  E-value: 3.88e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  39 YTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFA 118
Cdd:cd15979    7 YSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 119 SIYSMTAVAFDRYMAIIHPLQPRLSATATKV--VIFVIWVLALLLAFPQGYYSTTETMPSRV-----VCMIEWpehPNRT 191
Cdd:cd15979   87 STFSLVAIAIERYSAICNPLQSRVWQTRSHAyrVIAATWLLSGLIMIPYPVYSVTVPVPVGDrprghQCRHAW---PSAQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 192 YEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIpgdssdryheqvsAKRKVVKMMIVVVCTFAICWLPFHIFFLLP 271
Cdd:cd15979  164 VRQAWYVLLLLILFFIPGVVMIVAYGLISRELYRGLL-------------AKKRVIRMLVVIVAMFFLCWLPIFSANTWR 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 568941324 272 YINPDLYLKKF----IQQVYLasmwLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15979  231 AFDPLSAHRALsgapISFIHL----LSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
56-316 5.99e-19

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 86.54  E-value: 5.99e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:cd15125   24 IFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSVGVSVFTLTALSADRYKAIV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HPLQPRLSATA--TKVVIFVIWVLALLLAFPQGYYS----TTETMPSRVVCMIEWPEhPNRTYEKAYHICVTVLIYFLPL 209
Cdd:cd15125  104 NPMDIQTSSAVlrTCLKAIAIWVVSVLLAVPEAVFSevahIMPDDNTTFTACIPYPQ-TDEMHPKIHSVLIFLVYFLIPL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVGITLWAS--EIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFL---LPYINPDLYLKKFIq 284
Cdd:cd15125  183 AIISIYYYHIAKTLIKSahNIPGEYSEHSKRQMETRKRLAKIVLVFVGLFAFCWFPNHVLYMyrsFNYNEIDSSLGHMI- 261
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568941324 285 qVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15125  262 -VTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
56-313 6.53e-19

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 85.97  E-value: 6.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:cd15381   24 VFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYMNLYSSIYFLMMVSIDRYLALV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HPL---QPRLSATAtKVVIFVIWVLALLLAFPQGYYSTTETMPSRVV--CMIEWPehpNRTYEKAYHICVTVLIYFLPLL 210
Cdd:cd15381  104 KTMssgRMRRPACA-KLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNItaCVLDYP---SEGWHVALNILLNVVGFLIPLS 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLWASEIpgdssdRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPY-----INPDLYLKKFIQQ 285
Cdd:cd15381  180 IITFCSTQIIQVLRNNKM------QKFKEIQTERKATVLVLAVLLMFFICWLPFHIFTFLDTlhklgLISGCRWEDILDI 253
                        250       260
                 ....*....|....*....|....*...
gi 568941324 286 VYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15381  254 GTQIATFLAYSNSCLNPLLYVIVGKHFR 281
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
56-313 7.25e-19

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 85.94  E-value: 7.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:cd15073   24 TFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVVAVDRYLTIC 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HP-LQPRLSATATKVVIFVIWVLALLLA-FPQGYYSTTETMPSRVVCMIEWpEHPNRTYeKAYHICVTVLIYFLPLLVIG 213
Cdd:cd15073  104 RPdLGRKMTTNTYTVMILLAWTNAFFWAaMPLVGWASYALDPTGATCTINW-RKNDSSF-VSYTMSVIVVNFIVPLAVMF 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 214 YAYTVVGITL---WASEIPGDSSDRYHEQVSAKRkvvkMMIVVVCTFAICWLPFHIFFLLPYI-NPdlylKKFIQQVYLA 289
Cdd:cd15073  182 YCYYNVSRFVkkvLASDCLESVNIDWTDQNDVTK----MSVIMIVMFLVAWSPYSIVCLWASFgEP----KKIPPWMAII 253
                        250       260
                 ....*....|....*....|....
gi 568941324 290 SMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15073  254 PPLFAKSSTFYNPCIYVIANKKFR 277
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
54-313 9.09e-19

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 85.73  E-value: 9.09e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15402   22 ILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFNITGIAINRYCY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQ--PRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEwpehpnRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15402  102 ICHSLKydKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQYDPRIYSCTFA------QSVSSAYTIAVVFFHFILPIII 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLWA--SEIPGDSSDRYHEQvsaKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLA 289
Cdd:cd15402  176 VTFCYLRIWILVIQvrRRVKPDNKPKLKPH---DFRNFVTMFVVFVLFAVCWAPLNFIGLAVAVDPETIVPRIPEWLFVA 252
                        250       260
                 ....*....|....*....|....
gi 568941324 290 SMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15402  253 SYYMAYFNSCLNAIIYGLLNQNFR 276
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
54-316 1.28e-18

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 85.30  E-value: 1.28e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEAcMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15092   22 MYVILRHTKMKTATNIYIFNLALADT-LVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVA 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHP---LQPRLSATAtKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEhPNRTYEKAYHICVTVLIYFLPLL 210
Cdd:cd15092  101 ICHPikaLDVRTPHKA-KVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVEIPT-PQDYWDPVFGICVFLFSFIIPVL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLWASEIPGDSSdryhEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYI--NPDLYLKKFIQQVYL 288
Cdd:cd15092  179 IISVCYSLMIRRLRGVRLLSGSK----EKDRNLRRITRLVLVVVAVFVGCWTPIQIFVLAQGLgvQPSSETAVAILRFCT 254
                        250       260
                 ....*....|....*....|....*...
gi 568941324 289 AsmwLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15092  255 A---LGYVNSSLNPVLYAFLDENFKACF 279
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
54-315 1.95e-18

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 85.08  E-value: 1.95e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15083   22 IYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLAAIAVDRYLV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPL--QPRLSATATKVVIFVIWVLALLLAFPQgYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15083  102 ITRPMkaSVRISHRRALIVIAVVWLYSLLWVLPP-LFGWSRYVLEGLLTSCSFDYLSRDDANRSYVICLLIFGFVLPLLI 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLWASE-------IPGDSSDRYHEQVSAKRKVVKMMIVVVCT--FAICWLPFHIFFLLPYINPDLYLKKf 282
Cdd:cd15083  181 IIYCYSFIFRAVRRHEkamkemaKRFSKSELSSPKARRQAEVKTAKIALLLVllFCLAWTPYAVVALIGQFGYLEVLTP- 259
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568941324 283 iqqvyLASMW---LAMSSTMYNPIIYCCLNDRFRLG 315
Cdd:cd15083  260 -----LATAIpaaFAKTSAIYNPVIYAFSHPKFRRA 290
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
34-314 2.23e-18

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 84.55  E-value: 2.23e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  34 LWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVvnFTY-AVHNVWYYGLFYCKFHNFFP 112
Cdd:cd15079    2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPI--FIYnSFYEGWALGPLGCQIYAFLG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQP-RLSATATKVVIFVIWVLAL---LLAF--------PQGYYST------TETM 174
Cdd:cd15079   80 SLSGIGSIWTNAAIAYDRYNVIVKPLNGnPLTRGKALLLILFIWLYALpwaLLPLlfgwgryvPEGFLTScsfdylTRDW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 175 PSRVvcmiewpehpnrtyekaYHICVTVLIYFLPLLVIGYAYTVVGITLWASE---------IPGDSSDRYHEQ--VSAK 243
Cdd:cd15079  160 NTRS-----------------FVATIFVFAYVIPLIIIIYCYSFIVKAVFAHEkalreqakkMNVVSLRSNADAnkQSAE 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 244 RKVVKMMIVVVCTFAICWLPFH------IFFLLPYINPdlylkkfiqqvyLASMW---LAMSSTMYNPIIYCCLNDRFRL 314
Cdd:cd15079  223 IRIAKVALTNVFLWFIAWTPYAvvaligAFGNQSLLTP------------LVSMIpalFAKTAACYNPIVYAISHPKYRL 290
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
57-228 2.27e-18

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 84.21  E-value: 2.27e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15196   25 LYRRRRKLSRMHLFILHLSVADLLVALFNVLPQLIWDITYRFYGGDLLCRLVKYLQVVGMYASSYVLVATAIDRYIAICH 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQP-RLSATATKVVIFVIWVLALLLAFPQGY-YSTTETMPSRVVCmieWPEHPNRTYEKAYHICVTVLIYFLPLLVIGY 214
Cdd:cd15196  105 PLSShRWTSRRVHLMVAIAWVLSLLLSIPQLFiFSYQEVGSGVYDC---WATFEPPWGLRAYITWFTVAVFVVPLIILAF 181
                        170
                 ....*....|....
gi 568941324 215 AYTVVGITLWASEI 228
Cdd:cd15196  182 CYGRICYVVWRAKI 195
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
56-316 2.41e-18

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 84.41  E-value: 2.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:cd15192   24 VIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNLYASVFLLTCLSIDRYLAIV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HPLQPRLSATA--TKVVIFVIWVLALLLAFPQGYYSTTETMPS--RVVCMIEWPEHpNRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15192  104 HPMKSRLRRTLvvARVTCIVIWLLAGVASLPAIIHRDVFFIENtnITVCAFHYPSQ-NSTLLVGLGLMKNLLGFLIPFLI 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLWASeipgdssdrYHEQVSAKRK--VVKMMIVVVCTFAICWLPFHIFFLLPY-----INPDLYLKKFIQ 284
Cdd:cd15192  183 ILTCYTLIGKALKKA---------YEIQRNKPRNdeIFKMIMAVVLFFFFCWIPHQIFTFLDVliqlkVIQDCHIADIVD 253
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568941324 285 QVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15192  254 TAMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
54-313 2.43e-18

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 84.81  E-value: 2.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHK-RMRTVTNYFLVNLAFAEAcmaAFntVVNF----TYAVHNV-WYYGLFYCKFHNFFPIAALFASIYSMTAVA 127
Cdd:cd15190   32 LWTVFRSKrKRRRSADTFIANLALADL---TF--VVTLplwaVYTALGYhWPFGSFLCKLSSYLVFVNMYASVFCLTGLS 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 128 FDRYMAIIHPL-QPRL-SATATKVVIFVIWVLALLLAFPQGYYSTTETM--PSRVVCMIEWP----EHPNRTYEKAYHIC 199
Cdd:cd15190  107 FDRYLAIVRSLaSAKLrSRTSGIVALGVIWLLAALLALPALILRTTSDLegTNKVICDMDYSgvvsNESEWAWIAGLGLS 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 200 VTVLIYFLPLLVIGYAYTVVGITLwaseipgdsSDRYH----EQVSAKRKVVKMMIVVVCTFAICWLPFHI------FFL 269
Cdd:cd15190  187 STVLGFLLPFLIMLTCYFFIGRTV---------ARHFSklrrKEDKKKRRLLKIIITLVVTFALCWLPFHLvktlyaLMY 257
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568941324 270 LPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15190  258 LGILPFSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFR 301
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
57-316 4.44e-18

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 84.02  E-value: 4.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMR-TVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFyCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:cd15057   25 VLRFRHLRsKVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFGSF-CDVWVSFDIMCSTASILNLCVISVDRYWAIS 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HPL--QPRLSATATKVVIFVIWVLALLLAF---PQGYYSTTETMPSrvVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLL 210
Cdd:cd15057  104 SPFryERRMTRRRAFIMIAVAWTLSALISFipvQLGWHRADDTSEA--LALYADPCQCDSSLNRTYAISSSLISFYIPVA 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVV---------GITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVC--TFAICWLPFHIF-FLLPYINPDLY 278
Cdd:cd15057  182 IMIVTYTRIyriarrqirRIAALERAAQESTNPDSSLRSSLRRETKALKTLSIImgVFVCCWLPFFILnCVLPFCDLRTA 261
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568941324 279 LKKFI-QQVYLASMWLAMSSTMYNPIIYcCLNDRFRLGF 316
Cdd:cd15057  262 QFPCVpDTTFIVFVWLGWANSSLNPIIY-AFNADFRKAF 299
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
33-313 6.09e-18

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 83.31  E-value: 6.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd15374    1 ILLPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQP--RLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCM-IEWPEHPN 189
Cdd:cd15374   81 YANLYCSILFLTCISVHRYVGICHPIRAlrWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLCHdTTRPEEFD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 190 RTYEkaYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSsdryHEQVSAKRKVVKMMIVVVCTFAICWLPFHI--- 266
Cdd:cd15374  161 HYVH--YSSAVMVLLFGIPCLVIVVCYGLMARRLCKPRVGSSR----QQGPSSKKRSLKTIIMVLTVFAICFVPFHItrt 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568941324 267 -FFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15374  235 lYYVARLLKADCDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYR 282
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
57-316 6.77e-18

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 82.76  E-value: 6.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15064   25 ILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASILHLCVIALDRYWAITD 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPRLSATATK--VVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIewpehpnrTYEKAYHICVTVLIYFLPLLVIGY 214
Cdd:cd15064  105 AVEYAHKRTPKRaaVMIALVWTLSICISLPPLFGWRTPDSEDPSECLI--------SQDIGYTIFSTFGAFYIPLLLMLI 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 215 AYTvvgitlwaseipgdssdRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLasmWLA 294
Cdd:cd15064  177 LYW-----------------KIYRAAARERKAAKTLGIILGAFIVCWLPFFLVALIVPLCSHCWIPLALKSFFL---WLG 236
                        250       260
                 ....*....|....*....|..
gi 568941324 295 MSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15064  237 YFNSLINPLIYTFFNKDFRKAF 258
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
56-313 1.10e-17

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 82.52  E-value: 1.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMA------AFNTVVNFTyavhnvWYYGLFYCKFHNFFPIAALFASIYSMTAVAFD 129
Cdd:cd15189   24 VFLLHRRRLTVAEIYLGNLAAADLVFVsglpfwAMNILNQFN------WPFGELLCRVVNGVIKVNLYTSIYLLVMISQD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 130 RYMAIIHPLQPRL--SATATKVVIFVIWVLALLLAFPQGYYSTTETMPSR--VVCMIEWpehPNRTYEKAYHICVTVLIY 205
Cdd:cd15189   98 RYLALVKTMAARRlrRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDLniTACVLLY---PHEAWHFAHIVLLNIVGF 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 206 FLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAkrkvvkMMIVVVCTFAICWLPFHIFFLLPYINPDLYLK----- 280
Cdd:cd15189  175 LLPLLVITFCNYNILQALRTREESTRCEDRNDSKATA------LVLAVTLLFLVCWGPYHFFTFLDFLFDVGVLDecfwe 248
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568941324 281 KFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15189  249 HFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFR 281
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
54-313 1.56e-17

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 82.11  E-value: 1.56e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKF-HNFFPIaALFASIYSMTAVAFDRYM 132
Cdd:cd14987   22 VWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKItHLIFSI-NLFGSIFFLTCMSVDRYL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPLQP--RLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPS--RVVCMIEWPEHPNRTYEKAYHICVTVLIYFLP 208
Cdd:cd14987  101 SVTLFGNTssRRKKIVRRIICVLVWLLAFVASLPDTYFLKTVTSPSnnETYCRSFYPEESFKEWLIGMELVSIVLGFVIP 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIGYAYTVVGITLWAseipgdSSDRyheqvsAKRKVVKMMIVVVCTFAICWLPFH------IFFLLPYINPDLYLKKF 282
Cdd:cd14987  181 FPIIAVFYFLLARAISA------SSDQ------ERKSSRKIIFSYVVVFLVCWLPYHtvvlldILSFLHLIPFSCQLENF 248
                        250       260       270
                 ....*....|....*....|....*....|.
gi 568941324 283 IQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd14987  249 LYAALHVTQCFSLVHCCVNPILYSFINRNYR 279
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
38-315 2.12e-17

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 81.75  E-value: 2.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  38 AYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALF 117
Cdd:cd15968    6 CYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRFLFYFNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 118 ASIYSMTAVAFDRYMAIIHPLQPRLSAT--ATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCmieWPEHPNRTYEK- 194
Cdd:cd15968   86 GSILFLTCISVHRYLGICHPMRPWHKETrrAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVC---YDLAPPALFPHy 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 195 -AYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSdryheQVSAKRKVVKMMIVVVCTFAICWLPFHI---FFLL 270
Cdd:cd15968  163 vPYGMALTVSGFLLPFSIILWCYCLVVRTLCRTLGPAEPP-----AQARRRKSIRTIVTVTLLFALCFLPFHItrtIYLA 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568941324 271 PYINP--DLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLG 315
Cdd:cd15968  238 VRVTPgvPCHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKFGRR 284
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
56-313 2.30e-17

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 81.72  E-value: 2.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNY-FLVNLAFAEACMAAFNTVVNFTYAVHNvWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAI 134
Cdd:cd14999   22 VVMCLSMRPRASMYvYILNLALADLLYLLTIPFYVSTYFLKK-WYFGDVGCRLLFSLDFLTMHASIFTLTVMSTERYLAV 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 135 IHPLQP-RLSATATKVVIFVIWVLALLLAFPQGYYSTTET-----MPSRVVCMIEWPEHPNRTYekayhICVTVLIYFL- 207
Cdd:cd14999  101 VKPLDTvKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTvedksGGSKRICLPTWSEESYKVY-----LTLLFSTSIVi 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 208 PLLVIGYAYTVVGITLWASEIPGDSSDRyheQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYL-KKFIQQV 286
Cdd:cd14999  176 PGLVIGYLYIRLARKYWLSQAAASNSSR---KRLPKQKVLKMIFTIVLVFWACFLPFWIWQLLYLYSPSLSLsPRTTTYV 252
                        250       260
                 ....*....|....*....|....*..
gi 568941324 287 YLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd14999  253 NYLLTCLTYSNSCINPFLYTLLTKNYK 279
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
54-307 3.34e-17

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 81.02  E-value: 3.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEacMAAFNTVVNFTYAVHN-VWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd15121   22 VWSVLCRMKKRSVTCILVLNLALAD--AAVLLTAPFFLHFLSGgGWEFGSVVCKLCHYVCGVSMYASIFLITLMSMDRCL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPL--QPRLSATATKVVIFVIWVLALLLAFPQGYYSTTetMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLL 210
Cdd:cd15121  100 AVAKPFlsQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTV--LKKNINMKLCIPYHPSVGHEAFQYLFETITGFLLPFT 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLWASeipgdssdryheQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPY---INPDLYLKKFIQQVY 287
Cdd:cd15121  178 AIVTCYSTIGRRLRSA------------RFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVagaLQNQAGNASVLKAAK 245
                        250       260
                 ....*....|....*....|...
gi 568941324 288 LAS---MWLAMSSTMYNPIIYCC 307
Cdd:cd15121  246 LARpnvTALAFLSSSVNPVLYAF 268
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
54-316 3.71e-17

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 80.73  E-value: 3.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15327   22 ILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLCVISVDRYVG 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATK--VVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIewpehpnrTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15327  102 VKHSLKYPTIMTERKagVILVLLWVSSMVISIGPLLGWKEPPPPDESICSI--------TEEPGYALFSSLFSFYLPLMV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLWaseipgdssdryheQVSAKRKVVKMMIVVVCTFAICWLPFhiFFLLPY--INPDLylkKFIQQVYLA 289
Cdd:cd15327  174 ILVMYFRVYVVAL--------------KFSREKKAAKTLAIVVGVFILCWFPF--FFVLPLgsFFPAL---KPSEMVFKV 234
                        250       260
                 ....*....|....*....|....*..
gi 568941324 290 SMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15327  235 IFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
61-316 4.14e-17

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 80.44  E-value: 4.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAA----FNTVVNFTyavHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15052   29 KRLQNVTNYFLMSLAIADLLVGLlvmpLSILTELF---GGVWPLPLVLCLLWVTLDVLFCTASIMHLCTISLDRYMAIRY 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPRLSATATKVV--IFVIWVLALLLAFPQGYYS--TTETMPSRVVCMIEWPehpnrtyekAYHICVTVLIYFLPLLVI 212
Cdd:cd15052  106 PLRTRRNKSRTTVFlkIAIVWLISIGISSPIPVLGiiDTTNVLNNGTCVLFNP---------NFVIYGSIVAFFIPLLIM 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 213 GYAYTVVGITLwaseipgdssdryheqvSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINpDLYLKKFIQQVYLASMW 292
Cdd:cd15052  177 VVTYALTIRLL-----------------SNEQKASKVLGIVFAVFVICWCPFFITNILTGLC-EECNCRISPWLLSVFVW 238
                        250       260
                 ....*....|....*....|....
gi 568941324 293 LAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15052  239 LGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
39-316 4.29e-17

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 80.68  E-value: 4.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  39 YTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFA 118
Cdd:cd15978    7 YSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 119 SIYSMTAVAFDRYMAIIHPLQPRLSATATKV--VIFVIWVLALLLAFPQGYYS-----TTETMPSRVVCMIEWpehPNRT 191
Cdd:cd15978   87 STFNLVAISLERYSAICKPLKSRVWQTKSHAlkVIAATWCLSFTIMLPYPIYSnlvpfTRINNSTGNMCRLLW---PNDV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 192 YEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWaseipgdssdRYHEQVSAKRKVVKMMIVVVCTFAICWLPF---HIFF 268
Cdd:cd15978  164 TQQSWYIFLLLILFLIPGIVMMTAYGLISLELY----------RGIKFLMAKKRVIRMLIVIVILFFLCWTPIfsaNAWR 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 568941324 269 LLPYINPDLYLKKF-IQQVYLasmwLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15978  234 AFDTRSADRLLSGApISFIHL----LSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
53-316 4.61e-17

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 80.78  E-value: 4.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  53 VIWIILAHKRMRTVTNYFLVNLAFAEACMAAfnTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd15178   21 VVLVILYNRRSRSSTDVYLLHLAIADLLFAL--TLPFWAVSVVKGWIFGTFMCKLVSLLQEANFYSGILLLACISVDRYL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPLQPRLSATA-TKVVIFVIWVLALLLAFPQGYYSTTETMPS--RVVC--MIEwPEHPNRtYEKAYHICVTVLIYFL 207
Cdd:cd15178   99 AIVHATRALTQKRHlVKFVCAGVWLLSLLLSLPALLNRDAFKPPNsgRTVCyeNLG-NESADK-WRVVLRILRHTLGFLL 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 208 PLLVIGYAYTVVGITLwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHI------FFLLPYINPDLYLKK 281
Cdd:cd15178  177 PLVVMLFCYGFTIKTL------------LQTRSFQKHRAMRVIFAVVLAFLLCWLPYNVtvlidtLMRTKLITETCELRN 244
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568941324 282 FIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15178  245 HVDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
54-313 6.02e-17

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 80.53  E-value: 6.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFfpIAALF--ASIYSMTAVAFDRY 131
Cdd:cd15336   22 IYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAF--CGALFgiTSMITLLAISLDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 132 MAIIHPLQP--RLSATATKVVIFVIWVLALLLAFPQgYYSTTETMPSRVVCMIEW----PEHPNRTYekAYHICVTVliY 205
Cdd:cd15336  100 LVITKPLASirWVSKKRAMIIILLVWLYSLAWSLPP-LFGWSAYVPEGLLTSCTWdymtFTPSVRAY--TMLLFCFV--F 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 206 FLPLLVIGYAYTVVGITLWA---------SEIPGDSSDRYhEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPD 276
Cdd:cd15336  175 FIPLGIIIYCYLFIFLAIRStgrevqklgSQDRKEKAKQY-QRMKNEWKMAKIAFVVILLFVLSWSPYACVALIAWAGYA 253
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568941324 277 LYLKKFIQQVylaSMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15336  254 HLLTPYMKSV---PAVIAKASAIYNPIIYAITHPKYR 287
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
54-316 6.62e-17

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 79.94  E-value: 6.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15326   22 ILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAISIDRYIG 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIFV--IWVLALLLAFPQGYYSTTETMPSRVVCMIewpehpnrTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15326  102 VRHSLQYPTIVTRKRAILALlgVWVLSTVISIGPLLGWKEPAPPDDKVCEI--------TEEPFYALFSSLGSFYIPLIV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLWaseipgdssdryheQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLasm 291
Cdd:cd15326  174 ILVMYCRVYIVAL--------------KFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSHLKPPETLFKIIF--- 236
                        250       260
                 ....*....|....*....|....*
gi 568941324 292 WLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15326  237 WLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
57-316 6.96e-17

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 80.01  E-value: 6.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTV-VNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:cd15310   25 VLRERALQTTTNYLVVSLAVADLLVATLVMPwVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVV 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HPLQPRLSATATK-----VVIFVIWVLALLLAFPQGYYSTTETMPSrvVCMIEWPEhpnrtyekaYHICVTVLIYFLPLL 210
Cdd:cd15310  105 MPVHYQHGTGQSScrrvsLMITAVWVLAFAVSCPLLFGFNTTGDPT--VCSISNPD---------FVIYSSVVSFYLPFG 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLwaseipgdssdryheqvSAKRKVVKMMIVVVCTFAICWLPfhiFFLLPYINPDLYLKKFIQQVYLAS 290
Cdd:cd15310  174 VTLLVYVRIYVVL-----------------LREKKATQMLAIVLGAFIVCWLP---FFLTHILNTHCQACHVPPELYSAT 233
                        250       260
                 ....*....|....*....|....*.
gi 568941324 291 MWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15310  234 TWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
60-313 7.15e-17

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 80.20  E-value: 7.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  60 HKRMRTVTNYFLVNLAFAEACmaaFNTVVNFtYAVHNV--WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHP 137
Cdd:cd15179   28 QKKSRTMTDKYRLHLSVADLL---FVLTLPF-WAVDAAanWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHA 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 138 L---QPRlSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGY 214
Cdd:cd15179  104 TnsqRPR-KLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYPEDTFELWVVAFRFQHILVGLVLPGLVILT 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 215 AYTVVGITLwaseipgdSSDRYHEqvsaKRKVVKMMIVVVCTFAICWLPFHI------FFLLPYINPDLYLKKFIQQVYL 288
Cdd:cd15179  183 CYCIIISKL--------SHSKGHQ----KRKALKTTVILILAFFACWLPYYIgisidtFMLLEIIKQSCEMEQTVHKWIS 250
                        250       260
                 ....*....|....*....|....*
gi 568941324 289 ASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15179  251 ITEALAFFHCCLNPILYAFLGAKFK 275
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
61-316 8.88e-17

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 80.04  E-value: 8.88e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQP 140
Cdd:cd15048   29 KKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKY 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 141 RLSATATKVV--IFVIWVLALLLAFPQGYYSTTETMPSRV---VCMIEWPEHpnrtyeKAYHICVTVLIYFLPLLVIGYA 215
Cdd:cd15048  109 RAKQTKRRTVllMALVWILAFLLYGPAIIGWDLWTGYSIVptgDCEVEFFDH------FYFTFITSVLEFFIPFISVSFF 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 216 YTVVGITLWA-------SEIPGDSSDRYHEQVSAKRKVVKMM---------IVVVCTFAICWLPFHIFFLLPYINPDLYL 279
Cdd:cd15048  183 NLLIYLNIRKrsrrrplRSVPILPASQNPSRARSQREQVKLRrdrkaakslAILVLVFLICWAPYTILTIIRSFCSGSCV 262
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568941324 280 KKFiqqVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15048  263 DSY---LYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
30-322 1.01e-16

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 79.61  E-value: 1.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  30 WQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHN 109
Cdd:cd15299    1 WQVVLIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 110 FFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATK--VVIFVIWVLALLLAFPQ----GYYSTTETMPSRvVCMIE 183
Cdd:cd15299   81 SIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRagVMIGLAWVISFVLWAPAilfwQYFVGKRTVPPD-ECFIQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 184 WPEHPNRTYekayhiCVTVLIYFLPLlvigyayTVVGITLWaseipgdssdRYHEQVSAKRKVVKMMIVVVCTFAICWLP 263
Cdd:cd15299  160 FLSEPIITF------GTAIAAFYLPV-------TIMTILYW----------RIYKETIKEKKAAQTLSAILLAFIITWTP 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 264 FHIFFLLpyinpDLYLKKFIQQVYLA-SMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRC 322
Cdd:cd15299  217 YNIMVLV-----NTFCDSCIPKTYWNlGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLC 271
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
54-313 1.11e-16

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 79.57  E-value: 1.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15401   22 ILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIGSVFNITAIAINRYCY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQ--PRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEwpehpnRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15401  102 ICHSLRydKLYNMKKTCCYVCLTWVLTLAAIVPNFFVGSLQYDPRIYSCTFA------QTVSSSYTITVVVVHFIVPLSI 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYtvvgITLWASEIPGDSSDRYHEQVSAKRKVV---KMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYL 288
Cdd:cd15401  176 VTFCY----LRIWVLVIQVKHRVRQDSKQKLKANDIrnfLTMFVVFVLFAVCWGPLNFIGLAVAINPLKVAPKIPEWLFV 251
                        250       260
                 ....*....|....*....|....*
gi 568941324 289 ASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15401  252 LSYFMAYFNSCLNAVIYGVLNQNFR 276
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
54-313 1.35e-16

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 79.52  E-value: 1.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15084   32 IVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVGLWSLAILAFERYLV 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQP-RLSATATKVVIFVIWVLALLLAFPQGY-YSTTETMPSRVVCMIEWpeHPNRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15084  112 ICKPMGDfRFQQRHAVSGCAFTWGWSLLWTSPPLFgWSSYVPEGLRTSCGPNW--YTGGTNNNSYILALFVTCFALPLST 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLWASEIPGDSSDRYHEqvsAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLylkkfIQQVYLASM 291
Cdd:cd15084  190 IIFSYSNLLLTLRAVAAQQKESETTQR---AEKEVTRMVIAMVMAFLICWLPYATFAMVVATNKDV-----VIQPTLASL 261
                        250       260
                 ....*....|....*....|....
gi 568941324 292 --WLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15084  262 psYFSKTATVYNPIIYVFMNKQFR 285
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
54-313 1.47e-16

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 79.54  E-value: 1.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15131   22 MLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYSTILNITALSVERYFA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKV--VIFVIWVLALLLAFPqgyysttetmpsrvVCMIEWPEHPNRTYEKAYHIC------------ 199
Cdd:cd15131  102 ICFPLRAKVVVTKRRVklVILVLWAVSFLSAGP--------------IFVLVGVEHENGTNPIDTNECkateyavrsgll 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 200 -----VTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVcTFAICWLPFHI---FFLLP 271
Cdd:cd15131  168 timvwVSSVFFFLPVFCLTVLYSLIGRKLWRRRRENIGPNASHRDKNNRQTVKMLAVVVF-AFVLCWLPFHVgryLFSKS 246
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568941324 272 YINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15131  247 FEAGSLEIALISQYCNLVSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
61-316 1.80e-16

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 78.47  E-value: 1.80e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ- 139
Cdd:cd15329   29 KKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVLLCTASILNLCAISVDRYLVITRPLTy 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 140 -----PRLSATatkvVIFVIWVLALLLAFPQgyysttetmpsrvvcMIEWPEHPNRTY------EKAYHICVTVLIYFLP 208
Cdd:cd15329  109 avkrtPKRMAL----MIAIVWLLSALISIPP---------------LFGWKNKVNDPGvcqvsqDFGYQIYATFGAFYIP 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIgyayTVVGITLWASeipgdssdryheqVSAKRKVVKMMIVVVCTFAICWLPfhiFFLLPYINPDLYLKK---FIQQ 285
Cdd:cd15329  170 LIVM----LVLYYKIYRA-------------AKSERKAIKTLGIIMGAFTLCWLP---FFILALLRPFLKPIKcscIPLW 229
                        250       260       270
                 ....*....|....*....|....*....|.
gi 568941324 286 VYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15329  230 LSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
57-313 2.19e-16

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 78.74  E-value: 2.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15400   25 VFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITGIAINRYCYICH 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PL--QPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEwpehpnRTYEKAYHICVTVLIYFLPLLVIGY 214
Cdd:cd15400  105 SFayDKLYSRWNTLLYVCLIWALTVVAIVPNFFVGSLEYDPRIYSCTFV------QTASSSYTIAVVVIHFIVPITVVSF 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 215 AYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVcTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLASMWLA 294
Cdd:cd15400  179 CYLRIWVLVIQVRRKVKSESKPRLKPSDFRNFLTMFVVFV-IFAICWAPLNLIGLAVAINPQEMAPKVPEWLFVVSYFMA 257
                        250
                 ....*....|....*....
gi 568941324 295 MSSTMYNPIIYCCLNDRFR 313
Cdd:cd15400  258 YFNSCLNAIIYGLLNQNFR 276
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
60-316 2.57e-16

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 78.68  E-value: 2.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  60 HKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII-HPL 138
Cdd:cd15056   28 DRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTASIMHLCCIALDRYYAICcQPL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 139 QPRLSATATKVVIFVIWVLALLLAF-PQGYYSTTETMPSRVVCMiewpEHPNRTY-----EKAYHICVTVLIYFLPLLVI 212
Cdd:cd15056  108 VYKMTPLRVAVMLGGCWVIPTFISFlPIMQGWNHIGIEDLIAFN----CASGSTScvfmvNKPFAIICSTVAFYIPALLM 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 213 GYAYTVVGITLWAS-------EIPGDSSDRYHEQVSAKRKVVKMMIVVVCT----FAICWLPFHIFFLL-PYINpdlylK 280
Cdd:cd15056  184 VLAYYRIYVAAREQahqirslQRAGSSNHEADQHRNSRMRTETKAAKTLGIimgcFCVCWAPFFVTNIVdPFIG-----Y 258
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568941324 281 KFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15056  259 RVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
54-313 3.06e-16

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 78.62  E-value: 3.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIilAHKRM-RTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd15117   22 IWV--TGFRMtRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVVFNLFASVFLLTLISLDRCV 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPLQPRLSATATK--VVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMI------EWPEHPNRTYE------KAYHI 198
Cdd:cd15117  100 SVLWPVWARNHRTPARaaLVAVGAWLLALALSGPHLVFRDTRKENGCTHCYLnfdpwnETAEDPVLWLEtvvqrlSAQVI 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 199 CVTVLIYFLPLLVIGYAYTVVGITLWaseipgdssdryHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLP---YINP 275
Cdd:cd15117  180 TRFVLGFLVPLVIIGGCYGLIAARLW------------REGWVHSSRPFRVLTAVVAAFFLCWFPFHLVSLLElvvILNQ 247
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568941324 276 DLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15117  248 KEDLNPLLILLLPLSSSLACVNSCLNPLLYVFVGRDFR 285
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
54-307 3.18e-16

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 78.29  E-value: 3.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEacMAAFNTVVNFTYAV-HNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd14975   22 IWSILIKVKQRSVTMLLVLNLALAD--LAVLLTLPVWIYFLaTGTWDFGLAACKGCVYVCAVSMYASVFLITLMSLERFL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHP-LQPRLSATATKV-VIFVIWVLALLLAFPQGYYSTTETMPSRVVCMiewPEHPNRTYEKAYHICVTVLIYFLPLL 210
Cdd:cd14975  100 AVSRPfVSQGWRAKALAHkVLAIIWLLAVLLATPVIAFRHVEETVENGMCK---YRHYSDGQLVFHLLLETVVGFAVPFT 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLWASeipgdssdryheQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYI-------NPDLYLKKFI 283
Cdd:cd14975  177 AVVLCYSCLLRRLRRR------------RFRRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVseliggsKMAGTLGKVA 244
                        250       260
                 ....*....|....*....|....
gi 568941324 284 QQVYLASMWLAMSSTMYNPIIYCC 307
Cdd:cd14975  245 EAGRPIAGALAFLSSSINPLLYAF 268
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
54-316 3.44e-16

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 78.01  E-value: 3.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15325   22 ILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIISIDRYIG 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLqpRLSATATK----VVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIewpehpnrTYEKAYHICVTVLIYFLPL 209
Cdd:cd15325  102 VSYPL--RYPSIMTErrglLALLCVWVLSLVISIGPLFGWKEPAPEDETICQI--------TEEPGYALFSALGSFYLPL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVGITLWaseipgdssdryheQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLylkKFIQQVYLA 289
Cdd:cd15325  172 AIILVMYCRVYVVAL--------------KFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAY---KPSDTVFKI 234
                        250       260
                 ....*....|....*....|....*..
gi 568941324 290 SMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15325  235 TFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
57-310 4.13e-16

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 77.89  E-value: 4.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15398   25 LTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVMVSTLMLMSIAIVRYHMIKH 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTT---------ETMPSRVVCMIEWpehPNRTYEKAYHICVTVLIYFL 207
Cdd:cd15398  105 PLSNHLTANHGYFLLGTVWTLGFTICSPLPVFHKIvdlsetfnlESLKNKYLCIESW---PSDSYRIAFTISLLFVQYIL 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 208 PLLVIGYAYTVVGitlwaseipgdssdryhEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVY 287
Cdd:cd15398  182 PLVCLTVSHTSVC-----------------RSVKRSRSVFYRLTIVILAFAVSWMPLHLFHLVTDFNANLISNRHFKLVY 244
                        250       260
                 ....*....|....*....|...
gi 568941324 288 LASMWLAMSSTMYNPIIYCCLND 310
Cdd:cd15398  245 CICHLLGMLSCCLNPILYGFLNN 267
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
57-316 5.11e-16

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 77.42  E-value: 5.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15066   24 VMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFSTASILHLCCISVDRYYAIVQ 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPRLSATATKVVIF--VIWVLALLLAFP---QGYYSTTETMPSRVvcmiewpEHPNR---TYEKAYHICVTVLIYFLP 208
Cdd:cd15066  104 PLEYPSKMTKRRVAIMlaNVWISPALISFLpifLGWYTTEEHLQYRK-------THPDQcefVVNKIYALISSSVSFWIP 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIGYAYTvvgitlwaseipgdssdRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLL--------PYinPDLylk 280
Cdd:cd15066  177 CIVMIFTYY-----------------RIYLEAKREHKAAKTLGIIMGAFILCWLPFFLWYVTttlcgdacPY--PPI--- 234
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568941324 281 kfiqqVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15066  235 -----LVSILFWIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
57-316 9.21e-16

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 76.77  E-value: 9.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15063   25 VLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCAISLDRYLAITR 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPR--LSATATKVVIFVIWVLALLLAFPQ--GYYSTTET-MPSRVVCMIEWPEHPnrTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15063  105 PIRYPslMSTKRAKCLIAGVWVLSFVICFPPlvGWNDGKDGiMDYSGSSSLPCTCEL--TNGRGYVIYSALGSFYIPMLV 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTvvgitlwaseipgdssdRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLL-----PYINPDLYLKKFiqqv 286
Cdd:cd15063  183 MLFFYF-----------------RIYRAARMETKAAKTVAIIVGCFIFCWLPFFTVYLVrafceDCIPPLLFSVFF---- 241
                        250       260       270
                 ....*....|....*....|....*....|
gi 568941324 287 ylasmWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15063  242 -----WLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
92-316 9.50e-16

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 77.04  E-value: 9.50e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  92 YAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL-----QPRLSATatkVVIFVIWVLALLLAFPQG 166
Cdd:cd15375   60 YINGESWIFGEFMCKFIRFIFHFNLYGSILFLTCFSIFRYVVIVHPLrafqvQKRRWAI---VACAVVWVISLAEVSPMT 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 167 YYSTTETMPSRVVCMiEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLwaSEIPgdssdryHEQVSAKRKV 246
Cdd:cd15375  137 FLITTKEKNNRTICL-DFTSSDNLNTIWWYNWILTVLGFLLPLVIVTLCYTRIIYTL--AKGP-------HTGSASKQKA 206
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568941324 247 VKMMIVVVCTFAICWLPFHIF------FLLPYINPdlYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15375  207 RRLIILILLVFYVCFLPFHILrvvrieTRLPPVSC--CLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
54-316 1.14e-15

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 76.35  E-value: 1.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEacMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15173   22 IVIYIFYEKLRTLTDIFLVNLAVAD--LLFLCTLPFWAYSAAHEWIFGTVMCKITNGLYTINLYSSMLILTCITVDRFIV 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 II-----HPLQPRlSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHpnrtYEKAYHICVTVLIYFLP 208
Cdd:cd15173  100 IVqatkaHNCHAK-KMRWGKVVCTLVWVISLLLSLPQFIYSEVRNLSSKICSMVYPPDA----IEVVVNIIQMTVGFFLP 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIGYAYTVVGITLwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYL 288
Cdd:cd15173  175 LLAMIICYSVIIKTL------------LHAKGFQKHKSLKIIFVVVAVFILTQLPYNIMKLIRTLHIENTDSTNFKYAIL 242
                        250       260
                 ....*....|....*....|....*...
gi 568941324 289 ASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15173  243 ITEAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
54-314 1.14e-15

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 76.74  E-value: 1.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNftyAVHN-VWYY--GLFYCKFHNF----FPIAALFasiySMTAV 126
Cdd:cd15075   22 IIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLS---VVTNaVGYFnlGRVGCVLEGFavafFGIAALC----TVAVI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 127 AFDRYMAIIHPL-----QPR--LSATATKVVIFVIWVLALLLAFpqGYYSTTETMPSrvvCMIEWpeHPNRTYEKAYHIC 199
Cdd:cd15075   95 AVDRLFVVCKPLgtltfQTRhaLAGIASSWLWSLIWNTPPLFGW--GSYQLEGVMTS---CAPDW--YSRDPVNVSYILC 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 200 VTVLIYFLPLLVIGYAYTVVGITLW--ASEIPGDSSDRYHEQVSAKRKVVKMMIvvvcTFAICWLPFHIFFLLPYINPDL 277
Cdd:cd15075  168 YFSFCFAIPFAIILVSYGYLLWTLRqvAKLGVAEGGSTAKAEVQVARMVVVMVM----AFLLCWLPYAAFALTVVSKPDV 243
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568941324 278 YLKKFIQQVylaSMWLAMSSTMYNPIIYCCLNDRFRL 314
Cdd:cd15075  244 YINPLIATV---PMYLAKSSTVYNPIIYIFMNKQFRD 277
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
54-313 1.23e-15

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 76.35  E-value: 1.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIIlAHKRMRTVTNYFLVNLAFAE--ACMAAFNTVVNFtyAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRY 131
Cdd:cd15115   22 IWVA-GLKMKRTVNTIWFLNLAVADllCCLSLPFSIAHL--LLNGHWPYGRFLCKLLPSIIVLNMFASVFTLTAISLDRF 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 132 MAIIHPL--QPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEwpehpnrtYEKAYHICVTVLIYFLPL 209
Cdd:cd15115   99 LLVIKPVwaQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGYD--------FLVAITITRAVFGFLLPL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVGITLWASeipgdssdRYHEQVSAKRKVVKMMIVvvcTFAICWLPFHIFFLLPYINpDLYLKKFIQQVYLA 289
Cdd:cd15115  171 LIIAACYSFIAFRMQRG--------RFAKSQSKTFRVIIAVVV---AFFVCWAPYHIIGILSLYG-DPPLSKVLMSWDHL 238
                        250       260
                 ....*....|....*....|....
gi 568941324 290 SMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15115  239 SIALAYANSCLNPVLYVFMGKDFK 262
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
54-316 1.27e-15

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 76.23  E-value: 1.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15059   22 IVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCAISLDRYWS 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATAT--KVVIFVIWVLALLLAFPQ--GYYSTTETMPSRVVCMIewpehpnrTYEKAYHICVTVLIYFLPL 209
Cdd:cd15059  102 VTQAVEYNLKRTPRraKAMIAAVWIISAVISLPPlfGWKDEQPWHGAEPQCEL--------SDDPGYVLFSSIGSFYIPL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVgitlwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLylkKFIQQVYLA 289
Cdd:cd15059  174 LIMIIVYARI----------------YRAAKRKERRFTLVLGVVMGAFVLCWLPFFFTYPLVVVCKTC---GVPELLFKF 234
                        250       260
                 ....*....|....*....|....*..
gi 568941324 290 SMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15059  235 FFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
56-313 1.44e-15

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 76.33  E-value: 1.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMaafntVVNFTYAVHNV---WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd15181   24 ILLRRRRSRRTTENYLLHLALADLLL-----LLTFPFSVVESiagWVFGTFLCKLVGAIHKLNFYCSSLLLACISVDRYL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPLQPRLSATATKVVI--FVIWVLALLLAFPQGYY--STTETMPSRVVCMI-EWPEHPNR---TYEKAYHicvtVLI 204
Cdd:cd15181   99 AIVHAIHSYRHRRLRSVHLtcGSIWLVCFLLSLPNLVFleVETSTNANRTSCSFhQYGIHESNwwlTSRFLYH----VVG 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 205 YFLPLLVIGYAYTVVGITLWASEipgdssdRYHEQVSAKRKVVKMMIvvvcTFAICWLPFHI-FFL-----LPYINPDLY 278
Cdd:cd15181  175 FFLPLLIMGYCYATIVVTLCQSS-------RRLQKQKAIRVAILVTL----VFCLCWLPYNIvIFLdtlddLKAVVKNCK 243
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568941324 279 LKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15181  244 LNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFR 278
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
24-313 2.76e-15

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 75.60  E-value: 2.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  24 QFVQPtWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLF 103
Cdd:cd15082    6 KSIAP-WNFTVLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVW 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 104 YCKFHNF----FPIAALfasiYSMTAVAFDRYMAIIHPL-QPRLSATATKVVIFVIWVLALLLAFPQ--GYYSTTETMPS 176
Cdd:cd15082   85 ACVLEGFavtfFGIVAL----WSLAVLAFERFFVICRPLgNIRLQGKHAALGLLFVWTFSFIWTIPPvlGWSSYTVSKIG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 177 rVVCMIEWpeHPNRTYEKAYHICVTVLIYFLPLLVIGYAYtvvGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCT 256
Cdd:cd15082  161 -TTCEPNW--YSGNMHDHTYIITFFTTCFILPLGVIFVSY---GKLLQKLRKVSNTQGRLGNARKPERQVTRMVVVMIVA 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568941324 257 FAICWLPFHIFFLLPYINPDLYLKKFIQQVylaSMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15082  235 FMVCWTPYAAFSILVTAHPTIHLDPRLAAI---PAFFSKTAAVYNPIIYVFMNKQFR 288
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
54-313 4.46e-15

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 74.86  E-value: 4.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEacMAAFNTVVNFTYAVH-NVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd15185   22 VVILIKYRRLRIMTNIYLLNLAISD--LLFLFTLPFWIHYVRwNNWVFGHGMCKLLSGFYYLGLYSEIFFIILLTIDRYL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPLQPRLSATATKVVI--FVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLL 210
Cdd:cd15185  100 AIVHAVFALRARTVTFGIItsIITWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTEDSWKRFHALRMNIFGLALPLL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLWASeipgdSSDRYHEQVSakrkvvkMMIVVVCTFAICWLPFHIFFLLP-----YINPDLYLKKFIQQ 285
Cdd:cd15185  180 IMVICYTGIIKTLLRC-----PSKKKYKAIR-------LIFVIMVVFFIFWTPYNLVLLLSafqsiFFETDCERSKHLDL 247
                        250       260
                 ....*....|....*....|....*...
gi 568941324 286 VYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15185  248 AMQVTEVIAYTHCCINPVIYAFVGERFR 275
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
62-313 4.80e-15

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 74.89  E-value: 4.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  62 RMRTVTNYFLVNLAFAEacmaaFNTVVNFTYAVHN-----VWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15194   30 GVRRLIDIFISNLAASD-----FIFLVTLPLWVDKevvlgPWRSGSFLCKGSSYIISVNMYCSVFLLTCMSLDRYLAIVL 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPRLSATA--TKVVIFVIWVLALLLAFPqgyystteTMPSRVVCMIEWPEHPN----RTYEKAYHICVTVLIYFLPLL 210
Cdd:cd15194  105 PLVSRKFRTKhnAKVCCTCVWMLSCLLGLP--------TLLSRELKKYEEKEYCNedagTPSKVIFSLVSLIVAFFLPLL 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLWAseipgdSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINpDLYLKKFIQQVYLA- 289
Cdd:cd15194  177 SILTCYCTIIWKLCH------HYQKSGKHQKKLRKSIKIVFIVVAAFVFSWMPFNLFKALAIAS-GLQVEVTCLPYTLAq 249
                        250       260
                 ....*....|....*....|....*....
gi 568941324 290 -----SMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15194  250 lgmevSAPLAFANSCANPFIYYFFDRYIR 278
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
57-316 5.01e-15

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 74.45  E-value: 5.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15062   25 VACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCVISVDRYIGVRY 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPRLSATATK--VVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIewpehpnrTYEKAYHICVTVLIYFLPLLVIGY 214
Cdd:cd15062  105 PLNYPTIVTARRatVALLIVWVLSLVISIGPLLGWKEPAPADEQACGV--------NEEPGYVLFSSLGSFYLPLAIILV 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 215 AYTVVGITLWaseipgdssdryheQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLylkKFIQQVYLASMWLA 294
Cdd:cd15062  177 MYCRVYVVAF--------------KFSREKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLFSTL---KPPEPVFKVVFWLG 239
                        250       260
                 ....*....|....*....|..
gi 568941324 295 MSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15062  240 YFNSCLNPIIYPCSSREFKRAF 261
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
54-313 5.15e-15

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 74.87  E-value: 5.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15080   22 LYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQP-RLSATATKVVIFVIWVLALLLAFPQgYYSTTETMPS--RVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLL 210
Cdd:cd15080  102 VCKPMSNfRFGENHAIMGVAFTWVMALACAAPP-LVGWSRYIPEgmQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPLI 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLwaSEIPGDSSDRYHEQvSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVylaS 290
Cdd:cd15080  181 VIFFCYGRLVCTV--KEAAAQQQESATTQ-KAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSDFGPIFMTI---P 254
                        250       260
                 ....*....|....*....|...
gi 568941324 291 MWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15080  255 AFFAKSSAVYNPVIYILMNKQFR 277
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
50-316 5.50e-15

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 74.31  E-value: 5.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  50 NVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFD 129
Cdd:cd15331   18 NVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVLCCTASILHLVAIALD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 130 RYMAI--IHPLQPRlSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRV----VCMIewpehpnrTYEKAYHICVTVL 203
Cdd:cd15331   98 RYWAVtnIDYIRRR-TAKRILIMIAVVWFVSLIISIAPLFGWKDEDDLDRVlktgVCLI--------SQDYGYTIFSTVG 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 204 IYFLPLLVIGYAYtvVGITLWASeipgdssdryHEQVSAKrkvvkMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFI 283
Cdd:cd15331  169 AFYVPLLLMIIIY--WKIYQAAK----------RERKAAR-----TLAIITGAFVVCWLPFFLVALVMPFCGAWQISRFL 231
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568941324 284 QQVYLasmWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15331  232 ESFFL---WLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
64-313 1.30e-14

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 73.59  E-value: 1.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  64 RTVTNYFLVNLAFAE--ACMAAFNTVVNFtyAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL--Q 139
Cdd:cd15114   31 RSVNAVWFLNLAVADllCCLSLPILAVPI--AQDGHWPFGAAACKLLPSLILLNMYASVLLLTAISADRCLLVLRPVwcQ 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 140 PRLSATATKVVIFVIWVLALLLAFPQGYYSTT--ETMPSRVVCMIEWPEhpNRTYEKAYHICVTVLIYFLPLLVIGYAYT 217
Cdd:cd15114  109 NHRRARLAWIACGAAWLLALLLTVPSFIYRRIhqEHFPEKTVCVVDYGG--STGVEWAVAIIRFLLGFLGPLVVIASCHG 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 218 VVGITLWAseipgdssdryhEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYI---NPDLYLKKFIQQVYLASmwLA 294
Cdd:cd15114  187 VLLVRTWS------------RRRQKSRRTLKVVTAVVVGFFLCWTPYHVVGLIIAAsapNSRLLANALKADPLTVS--LA 252
                        250
                 ....*....|....*....
gi 568941324 295 MSSTMYNPIIYCCLNDRFR 313
Cdd:cd15114  253 YINSCLNPIIYVVAGRGFR 271
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
54-316 1.32e-14

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 73.57  E-value: 1.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEaCM---AAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd14995   22 VLVVLRTRHMRTPTNCYLVSLAVAD-LMvlvAAGLPNEIESLLGPDSWIYGYAGCLLITYLQYLGINASSLSITAFTIER 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQPRLSAT---ATKVVIFViWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFL 207
Cdd:cd14995  101 YIAICHPMKAQFICTvsrAKKIICFV-WIFTSLYCSPWLFLLDLSIKHYGDDIVVRCGYKVSRHYYLPIYLADFVLFYVI 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 208 PLLVIGYAYTVVGITLWASeipgdssdryheqvsaKRKVVKMMIVVVCTFAICWLPFHIFFLlpyinpdlyLKKFIQQVY 287
Cdd:cd14995  180 PLLLAIVLYGLIGRILFSS----------------RKQVTKMLAVVVVLFALLWMPYRTLVV---------YNSFASPPY 234
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568941324 288 LASMWLAMSSTM------YNPIIYCCLNDRFRLGF 316
Cdd:cd14995  235 LDLWFLLFCRTCiylnsaINPILYNLMSQKFRAAF 269
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
54-314 1.69e-14

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 73.24  E-value: 1.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIIlAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15119   22 IWVT-GFKWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAVLNMFASVLFLTVISLDRYIS 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPL--QPRLSATATKVVIFVIWVLALLLAFPQGYY-STTETMPSRVVCMIEWPEHPNRTYEKAYHICV---TVLIYFL 207
Cdd:cd15119  101 LAHPVwsHRYRTLKSALILCGIVWLSAAAISGPALYFrDTMELSINVTICFNNFHKHDGDLIVMRHTILVwvrFFFGFLF 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 208 PLLVIGYAYTVVGITLWASEIPGdsSDRYHEQVSAkrkvvkmmivVVCTFAICWLPFHIFFLLPY-INPDLYLKKFIQQV 286
Cdd:cd15119  181 PLLTMVVCYSLLAIKVKRRTLLI--SSKFFWTISA----------VIVAFFVCWTPYHIFSILELsIHHSSYLHNVLRAG 248
                        250       260
                 ....*....|....*....|....*...
gi 568941324 287 YLASMWLAMSSTMYNPIIYCCLNDRFRL 314
Cdd:cd15119  249 IPLATSLAFINSCLNPILYVLIGKKFKA 276
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
57-316 2.06e-14

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 72.70  E-value: 2.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15330   25 IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITD 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQ------PRLSAtatkVVIFVIWVLALLLAFPQGY-YSTTETMPSRVVCMIewpehpnrTYEKAYHICVTVLIYFLPL 209
Cdd:cd15330  105 PIDyvnkrtPRRAA----VLISLTWLIGFSISIPPMLgWRTPEDRSDPDACTI--------SKDPGYTIYSTFGAFYIPL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYtvvgitlwaseipgdssDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFL-LPYINPDLYLKKFIQQVYl 288
Cdd:cd15330  173 ILMLVLY-----------------GRIFKAAARERKTVKTLGIIMGTFILCWLPFFIVALvLPFCESTCHMPELLGAII- 234
                        250       260
                 ....*....|....*....|....*...
gi 568941324 289 asMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15330  235 --NWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
54-223 2.22e-14

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 72.86  E-value: 2.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEacMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15174   22 VLIYTYYRRRKTMTDVYLLNLAIAD--LLFLCTLPFWATAASSGWVFGTFLCKVVNSMYKINFYSCMLLLTCISVDRYIA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATA----TKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVC-MIEWPEHPNRTYEKAYHICVTVLiYFLP 208
Cdd:cd15174  100 IVQATKAHNSKNKrllySKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCtMVYPSNESNRFKVAVLALKVTVG-FFLP 178
                        170
                 ....*....|....*
gi 568941324 209 LLVIGYAYTVVGITL 223
Cdd:cd15174  179 FVVMVICYTLIIHTL 193
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
68-313 2.33e-14

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 73.01  E-value: 2.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  68 NYFLVNLAFAEacmaaFNTVVNFTY-AVHNV----WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL--QP 140
Cdd:cd15926   37 NLFVTSLAVTD-----FQFVLTLPFwAVENAldftWLFGKAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVASALksKR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 141 RLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPN--RTYEKAYHICVTVLIYFLPLLVIGYAYTV 218
Cdd:cd15926  112 RRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFPDNRGnaQFWLGLYHAQKVLLGFLIPLGIISLCYLL 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 219 VgITLWASEIPGDSSDRYHEQVSAKrkvvkmMIVVVCTFAICWLPFHIF----FLLPYINPDLYLKKFIQQVYL--ASMW 292
Cdd:cd15926  192 L-VRFITDKNITGSSTKRRSKVTKS------VTIVVLSFFLCWLPNQALttwgILIKLNVVHFSYEYFTTQVYIfpITVC 264
                        250       260
                 ....*....|....*....|.
gi 568941324 293 LAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15926  265 LAHSNSCLNPILYCLMRREFR 285
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
57-313 2.43e-14

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 72.86  E-value: 2.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15372   24 VLATQVKRLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVH 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPRLSATATKVVIF--VIWVLALLLAFPQGYYSTTETMPS--RVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVI 212
Cdd:cd15372  104 PFFARTLRSRRFALCMctAIWLIAAALTLPLTLQRQSYPLERlnITLCHDVLPLDEQDTYLFYYFACLAVLGFLLPLVVI 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 213 GYAYTVVGITLwaseipGDSSDRYHEQVSakrkvvkMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLASMW 292
Cdd:cd15372  184 LFCYGSVLHTL------LRSGQRYGHAMK-------LTVLVLVSFVLCFTPSNLLLLLHYSDPTLDDGGNLYIVYMVSLA 250
                        250       260
                 ....*....|....*....|.
gi 568941324 293 LAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15372  251 ISTLNSCVDPFIYYYVSEEFR 271
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
54-313 2.89e-14

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 72.67  E-value: 2.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFntVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd14968   22 IWAVKLNRALRTVTNYFIVSLAVADILVGAL--AIPLAILISLGLPTNFHGCLFMACLVLVLTQSSIFSLLAIAIDRYLA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKV--VIFVIWVLALLLAF-PQ-GYYSTTETMPSRVVCMIE--WPEHPNRTYEKAYHICVTVLIYFL 207
Cdd:cd14968  100 IKIPLRYKSLVTGRRAwgAIAVCWVLSFLVGLtPMfGWNNGAPLESGCGEGGIQclFEEVIPMDYMVYFNFFACVLVPLL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 208 PLLVI-GYAYTVVGITLWASEIP---GDSSDRYHEQVSAKRKVVKMMIVvvctFAICWLPFHIFFLLPYINPDLYLKKFI 283
Cdd:cd14968  180 IMLVIyLRIFRVIRKQLRQIESLlrsRRSRSTLQKEVKAAKSLAIILFL----FALCWLPLHIINCITLFCPECKVPKIL 255
                        250       260       270
                 ....*....|....*....|....*....|
gi 568941324 284 qqVYLASMWLAMSSTMyNPIIYCCLNDRFR 313
Cdd:cd14968  256 --TYIAILLSHANSAV-NPIVYAYRIRKFR 282
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
54-313 2.95e-14

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 72.49  E-value: 2.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIIlAHKRMRTVTNYFLVNLAFAEACMAAFnTVVNFTY-AVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd15116   22 IFIT-GFKMKKTVNTVWFLNLAVADFLFTFF-LPFSIAYtAMDFHWPFGRFMCKLNSFLLFLNMFTSVFLLTVISIDRCI 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPL--QPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMP--SRVVCM----------IEWPEHPNRTYEKAYHI 198
Cdd:cd15116  100 SVVFPVwsQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQnnNKIICFnnfslsgdnsSPEVNQLRNMRHQVMTI 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 199 CVTVLIYFLPLLVIGYAYTVVGITLwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLY 278
Cdd:cd15116  180 TRFLLGFLIPFTIIICCYAAIVLKL------------KRNRLAKSSKPFKIIAAVIVTFFLCWAPYHILNLLEMEATRSP 247
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568941324 279 LKKFIQQVYLASMwLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15116  248 ASVFKIGLPITSS-LAFINSCLNPILYVFMGQDFK 281
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
33-305 3.10e-14

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 72.49  E-value: 3.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd16001    1 ILLPVTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVI--FVIWVLALLLAFPQGYYSTTETMPSRVVCM-IEWPEHPN 189
Cdd:cd16001   81 YTNLYGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIgsAATWILVVLQLLPTLVYARTGSINNRTVCYdLTSPDNFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 190 RTYekAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSdryheqvSAKRKVVKMMIVVVCT-FAICWLPFHI-- 266
Cdd:cd16001  161 NYF--PYGMVLTVTGFLIPFLIILLCYCLMIKSLIRSEEAAGVG-------KAARAKSIRTILLVCGlFALCFVPFHItr 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568941324 267 ---FFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIY 305
Cdd:cd16001  232 tiyLFVRVYLVQDCPLLQFVSLAYKIWRPLVSFNSCINPLLY 273
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
33-313 4.20e-14

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 72.09  E-value: 4.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd15162    1 VFLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATK--VVIFVIWVLALLLAFPqgYYSTTETM----PSRVVCMIEWPE 186
Cdd:cd15162   81 YGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYalGTCLAIWLLALLVTLP--LYLVKQTIflpaLDITTCHDVLPE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 187 HPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLwaseipGDSSDRYHEqvSAKRKVVKMMIVVVCTFAICWLPFHI 266
Cdd:cd15162  159 QLLVGDWFYYFLSLAIVGFLIPFILTASCYVATIRTL------AALEDENSE--KKKKRAIKLAATVLAIFIICFAPSNL 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568941324 267 FFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15162  231 LLLAHYSLISSSGTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFR 277
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
54-313 4.74e-14

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 72.09  E-value: 4.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15193   22 IALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAVNRCSSILFLTGMSVDRYLA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIF--VIWVLALLLAFPQGYYsttETMPSRVVCMiewpEHPNRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15193  102 VVKLLDSRPLRTRRCALITccIIWAVSLVLGIPSLVY---RNLINESVCV----EDSSSRFFQGISLATLFLTFVLPLIV 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLWASEIPGDSSDRyheqvsAKRKVVKMMIVVVCTFAICWLPF------HIFFLLPYINPDLYLKKFIQQ 285
Cdd:cd15193  175 ILFCYCSILVRLRRHFHGAKRTGR------RRRNSLRIVFAIVTAFVLSWLPFntlkavRLLLELGGGVLPCHTTVAIRQ 248
                        250       260
                 ....*....|....*....|....*...
gi 568941324 286 VYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15193  249 GLTITACLAFVNSCVNPLIYSLLDRHFR 276
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
54-313 4.79e-14

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 72.14  E-value: 4.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMaafntVVNFTYAVHNV-----WYYGLFYCKFHNFFPIAALFASIYSMTAVAF 128
Cdd:cd15380   22 LFVFLLPRRRLTIAEIYLANLAASDLVF-----VLGLPFWAENIrnqfnWPFGNFLCRVISGVIKANLFISIFLVVAISQ 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 129 DRYMAIIHPLQPRL--SATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVV--CMIEWPeHPnrtyekAYHicvtvLI 204
Cdd:cd15380   97 DRYRTLVHTMTSRRqrSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVPDLNIsaCILLFP-HE------AWH-----FA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 205 YFLPLLVIGYAYTVVGITLWASEIPgdSSDRYHEQVSAKRK-------VVKMMIVVVCTFAICWLPFHIFFLLPYIN--- 274
Cdd:cd15380  165 RRVELNIVGFLLPLAAIVFFNFHII--ASLRERTEESRKRCgglkdtkATRLILTLVLMFLVCWTPYHFFAFLDFLFqve 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568941324 275 --PDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15380  243 viQGCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
61-316 4.84e-14

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 71.61  E-value: 4.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAAF-NTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ 139
Cdd:cd15053   29 RSLQTATNYFIVSLAVADLLVAILvMPFAVYVEVNGGKWYLGPILCDIYIAMDVMCSTASIFNLCAISIDRYIAVTQPIK 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 140 PRLSATATKVV--IFVIWVLALLLAFPqgyysttetmpsrVVCMIEWPEHPN----RTYEKAYHICVTVLIYFLPLLVIG 213
Cdd:cd15053  109 YARQKNSKRVLltIAIVWVVSAAIACP-------------LLFGLNNVPYRDpeecRFYNPDFIIYSSISSFYIPCIVML 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 214 YAYTVVGITLwaseipgdssdryheqvSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPdLYLKKFIQ---QVYLAS 290
Cdd:cd15053  176 LLYYRIFRAL-----------------RREKKATKTLAIVLGVFLFCWLPFFTLNILNAICP-KLQNQSCHvgpALFSLT 237
                        250       260
                 ....*....|....*....|....*..
gi 568941324 291 MWLA-MSSTMyNPIIYCCLNDRFRLGF 316
Cdd:cd15053  238 TWLGyVNSFL-NPIIYTIFNIEFRKAF 263
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
63-316 6.39e-14

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 71.15  E-value: 6.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  63 MRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRL 142
Cdd:cd17790   31 LKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNLLIISFDRYFSITRPLTYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 143 SATATKVVI---------FVIWVLALLlaFPQgYYSTTETMPSrVVCMIEWPEHPNRTYEKAyhicvtVLIYFLPLlvig 213
Cdd:cd17790  111 KRTPRRAAImiglawlisFVLWAPAIL--FWQ-YLVGERTVLA-GQCYIQFLSQPIITFGTA------IAAFYLPV---- 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 214 yayTVVGITLWaseipgdssdRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYlasmWL 293
Cdd:cd17790  177 ---TIMIILYW----------RIYRETIKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPKTLWELGY----WL 239
                        250       260
                 ....*....|....*....|...
gi 568941324 294 AMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd17790  240 CYVNSTVNPMCYALCNKSFRDTF 262
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
63-313 7.55e-14

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 70.86  E-value: 7.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  63 MRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPlQPRL 142
Cdd:cd15213   31 MRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLIIVQR-QDKL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 143 SATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVV-CMIEWPEHPNrtyEKAYHICVTVLIYFLPLLVIGYAYTVVGI 221
Cdd:cd15213  110 NPHRAKILIAVSWVLSFCVSFPPLVGWGKYEFPPRAPqCVLGYTESPA---DRIYVVLLLVAVFFIPFLIMLYSYFCILN 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 222 TLwaseipgdssdryheqVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLpyinpdLYLKKFIQQVYLAS---MWLAMSST 298
Cdd:cd15213  187 TV----------------RSFKTRAFTTILILFIGFSVCWLPYTVYSLL------SVFSRYSSSFYVIStclLWLSYLKS 244
                        250
                 ....*....|....*
gi 568941324 299 MYNPIIYCCLNDRFR 313
Cdd:cd15213  245 AFNPVIYCWRIKKFR 259
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
62-316 8.02e-14

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 71.48  E-value: 8.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  62 RMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLqpR 141
Cdd:cd15959   30 RLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASIETLCAIAVDRYLAITNPL--R 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 142 LSATATKV----VIFVIWVLALLLAF-PQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAY 216
Cdd:cd15959  108 YEALVTKRrartAVCLVWAISAAISFlPIMNQWWRDGADEEAQRCYDNPRCCDFVTNMPYAIVSSTVSFYVPLLVMIFVY 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 217 TVVGITL-------------WASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCT-------FAICWLPFHIFFLLPYINPD 276
Cdd:cd15959  188 VRVFVVAtrqvrlirkdkvrFPPEESPPAESRPACGRRPSRLLAIKEHKALKTlgiimgtFTLCWLPFFVANIIKVFCRS 267
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568941324 277 LylkkFIQQVYLASMWLAMSSTMYNPIIYCCLNDrFRLGF 316
Cdd:cd15959  268 L----VPDPAFLFLNWLGYANSAFNPIIYCRSPD-FRSAF 302
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
37-313 1.56e-13

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 70.71  E-value: 1.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  37 AAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAAL 116
Cdd:cd15377    5 AVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 117 FASIYSMTAVAFDRYMAIIHPLQP--RLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVV-CMIEWPEHPNRTYe 193
Cdd:cd15377   85 YGSILFLTCISVHRYTGVVHPLKSlgRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTItCYDTTSDEYLRSY- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 194 KAYHICVTVLIYFLPLLVIGYAYTVVGITLwaseIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIF------ 267
Cdd:cd15377  164 FIYSMCTTVAMFCVPFILILGCYGLIVRAL----IYKDMKYTEENNAPLRRKSIYLVIIVLTVFAVSYLPFHVMktlnlr 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568941324 268 FLLPYINPDL-YLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15377  240 ARLDFQTPAMcAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFR 286
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
54-305 1.62e-13

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 70.54  E-value: 1.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15384   22 IIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYLSTYITVLISLDRCVA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPsRVVCMIEWPEHPNRT---YEKAYHICVTVLIYFLPLL 210
Cdd:cd15384  102 ILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAVIFHVERGP-FVEDFHQCVTYGFYTaewQEQLYNMLSLVFMFPIPLV 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLWASEIPGDSSDRY---HEQV------SAKRKVVKMMIVVVCTFAICWLPFHIFFLL-PYINPdlylK 280
Cdd:cd15384  181 IMVTCYVLIFITLSKSSRDFQGLEIYtrnRGPNrqrlfhKAKVKSLRMSAVIVTAFILCWTPYYVIMIWfLFFNP----Y 256
                        250       260
                 ....*....|....*....|....*
gi 568941324 281 KFIQQVYLASMWLAMSSTMYNPIIY 305
Cdd:cd15384  257 PLNDILFDVIFFFGMSNSCVNPLIY 281
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
33-266 1.72e-13

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 70.29  E-value: 1.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd15379    1 VLLPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPLQP---RLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPN 189
Cdd:cd15379   81 YTNLHGSILFLTCISVQRYLGICHPLASwhkKKGKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVCYDLSPPARS 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941324 190 RTYeKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQvsaKRKVVKMMIVVVCTFAICWLPFHI 266
Cdd:cd15379  161 TAY-FPYGITLTRTGFLLPFAARLACYCSMATILCRVVIAVAVVAAPGEK---RGKAARMIIVVAAVFLISFLPFHY 233
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
56-313 1.73e-13

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 70.10  E-value: 1.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMR-TVTNYFLVNLAFAEACMaafntVVNF-TYAVHNV--WYYGLFYCKFhnffpIAALF-----ASIYSMTAV 126
Cdd:cd15180   23 AVLLQKRRNlSVTDTFILHLALADILL-----LVTLpFWAVQAVhgWIFGTGLCKL-----AGAVFkinfyCGIFLLACI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 127 AFDRYMAIIHPLQ--PRLSATATKVVIFVIWVLALLLAFPQGYY--STTETMPSRVVCMIEWPeHPNRTYEKAYHICVTV 202
Cdd:cd15180   93 SFDRYLSIVHAVQmySRKKPMLVHLSCLIVWLFCLLLSIPDFIFleATKDPRQNKTECVHNFP-QSDTYWWLALRLLYHI 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 203 LIYFLPLLVIGYAYTVVGITLWASEipgdssdryheQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKf 282
Cdd:cd15180  172 VGFLLPLAVMVYCYTSILLRLLRSS-----------QGFQKQRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVLDR- 239
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568941324 283 iQQVYLASMWLAMSST--------MYNPIIYCCLNDRFR 313
Cdd:cd15180  240 -NCGTESRLDIALSVTsslgyfhcCLNPLLYAFVGVKFR 277
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
33-305 1.75e-13

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 70.46  E-value: 1.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEA--CMAAFNTVVNFTYAVHnvWYYGLFYCKFHNF 110
Cdd:cd15159    1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDIlfTLALPGRIAYYALGFD--WPFGDWLCRLTAL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 111 FPIAALFASIYSMTAVAFDRYMAIIHPLQ-PRL-SATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMiewpEHP 188
Cdd:cd15159   79 LFYINTYAGVNFMTCLSVDRYIAVVHPLRrHRLrKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEMGGRITCM----EYP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 189 NrtYEKAYHICVTVLI-----YFLPLLVIGYAYTVVGITLWASEipgdSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLP 263
Cdd:cd15159  155 N--FEKIKRLPLILLGacvigFGVPVGIILFCYSQITLKLCRTA----KENPLTEKSGHHKKACNVILLVLLVFVVCFSP 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568941324 264 FHIFFLLPYINPDLY------LKKFIQQVYLASMWLAMSSTMyNPIIY 305
Cdd:cd15159  229 YHLNIIQFMIRKLLYqpscseLKAFKISLQITVCLMNLNCCL-DPFIY 275
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
54-305 1.95e-13

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 70.22  E-value: 1.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILA--HKRMRTVTNYFLVNLAFAEACMAAFnTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRY 131
Cdd:cd15122   22 IWSILWkmKARGRSVTCILILNLAVADGAVLLL-TPFFITFLTRKTWPFGQAVCKAVYYLCCLSMYASIFIIGLMSLDRC 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 132 MAIIHP-LQPRLSATATKV-VIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEwPEHPNRTYEKAYHICVTVLIYFLPL 209
Cdd:cd15122  101 LAVTRPyLAQSLRKKALVRkILLAIWLLALLLALPAFVYRHVWKDEGMNDRICE-PCHASRGHAIFHYTFETLVAFVLPF 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVGITLWASEipGDSSDRYHEQVSAkrkvvkmmivVVCTFAICWLPFHIFFLLPYI----NPDLY--LKKFI 283
Cdd:cd15122  180 GVILFSYSVILVRLKGAR--FRRRARVEKLIAA----------IVVAFALLWVPYHVVNLLQVVanlaPGEVLekLGGAA 247
                        250       260
                 ....*....|....*....|..
gi 568941324 284 QQVYLASMWLAMSSTMYNPIIY 305
Cdd:cd15122  248 KAARAGATALAFFSSSVNPLLY 269
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
57-305 2.75e-13

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 69.89  E-value: 2.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15055   25 ISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCD 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQ--PRLSATATKVVIFVIWVLALLLAFPQGY-YSTTETMPSRVVCMIEWPEHPNRTYEkayhICVTVLIYFLPLLVIG 213
Cdd:cd15055  105 PLLypTKITIRRVKICICLCWFVSALYSSVLLYdNLNQPGLIRYNSCYGECVVVVNFIWG----VVDLVLTFILPCTVMI 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 214 YAYTVV-------------GITLWASEIPGDSSDRYHEQVSAKrkvvkmmivvvcT-------FAICWLPFHIFFLL-PY 272
Cdd:cd15055  181 VLYMRIfvvarsqarairsHTAQVSLEGSSKKVSKKSERKAAK------------TlgivvgvFLLCWLPYYIVSLVdPY 248
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568941324 273 INPDLYLKKFIqqvylasMWLAMSSTMYNPIIY 305
Cdd:cd15055  249 ISTPSSVFDVL-------IWLGYFNSCLNPLIY 274
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
54-223 2.76e-13

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 69.77  E-value: 2.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAaFNTVVNFTYAVHNvWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15176   22 VAIYAYYKKLKTKTDVYILNLAVADLLLL-FTLPFWAADAVNG-WVLGTAMCKITSALYTMNFSCGMQFLACISVDRYVA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIG 213
Cdd:cd15176  100 ITKATSRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRCLPVFPPSLVTSAKATIQILEVLLGFVLPFLVMV 179
                        170
                 ....*....|
gi 568941324 214 YAYTVVGITL 223
Cdd:cd15176  180 FCYSRVARAL 189
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
33-316 2.79e-13

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 69.59  E-value: 2.79e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTN---YFLVNLAFAEACMAAFNTVV---NFTYaVHNVWYYGLFYCK 106
Cdd:cd15130    1 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQStvrYHLGSLALSDLLILLLAMPVelyNFIW-VHHPWAFGDAGCR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 107 FHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPR--LSATATKVVIFVIWVLALLLAFP------QGYYSTTETMPSRV 178
Cdd:cd15130   80 GYYFLRDACTYATALNVASLSVERYLAICHPFKAKtlMSRSRTKKFISAIWLASALLAIPmlftmgLQNESDDGTHPGGL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 179 VCMIewpeHPNRTYEKAYhICVTVLIYFL-PLLVIGYAYTVVGITLwaseipgdssdryheqVSAKRKVVKMMIVVVCTF 257
Cdd:cd15130  160 VCTP----IVDTATLKVV-IQVNTFMSFLfPMLVTSILNTVIANKL----------------VQALRRGVLVLRAVVIAF 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568941324 258 AICWLPFHIFFLLPYINPD----LYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15130  219 VVCWLPYHVRRLMFCYISDeqwtTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVF 281
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
33-313 2.94e-13

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 69.52  E-value: 2.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHK-RMRTVTNYFLVNLAFAEACMA------AFNTVVNFTyavhnvWYYGLFYC 105
Cdd:cd15925    1 ILVALAYGLVCAIGLLGNLAVMYLLRNCArRAPPPIDVFVFNLALADFGFAltlpfwAVESALDFH------WPFGGAMC 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 106 KFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQP--RLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIE 183
Cdd:cd15925   75 KMVLTATVLNVYASVFLLTAMSVTRYWVVASAAGPgtHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLLK 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 184 WPEhpnRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRyheqvsaKRKVVKMMIVVVCTFAICWLP 263
Cdd:cd15925  155 FPS---NYWLGAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQHKVNQNNRQR-------QSVIARSVRLVVASFFLCWFP 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568941324 264 FHI---------FFLLPYINPDLYLKKFIQQVYLAsmwLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15925  225 NHVvtfwgvlvkFRAVPWNSTFYFIHTYVFPVTTC---LAHSNSCLNPVLYCLMRREFR 280
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
54-322 4.42e-13

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 69.21  E-value: 4.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILA---HKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15307   19 ILVCLAiawERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIMHLCTISVDR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQPRLSATATKVV--IFVIWVLALLLAFPQGYYSTTETMPSRV--VCMIEWPehpnrtyekAYHICVTVLIYF 206
Cdd:cd15307   99 YLSLRYPMRFGRNKTRRRVTlkIVFVWLLSIAMSLPLSLMYSKDHASVLVngTCQIPDP---------VYKLVGSIVCFY 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 207 LPLLVIGYAYTVVGITLwaseipGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYlKKFIQQV 286
Cdd:cd15307  170 IPLGVMLLTYCLTVRLL------ARQRSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECE-ERISHWV 242
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568941324 287 YLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRC 322
Cdd:cd15307  243 FDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLC 278
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
56-313 4.80e-13

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 69.26  E-value: 4.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTV--TNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15382   23 LILLRNRRRKRsrVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRAFGLYLSSFVLVCISLDRYFA 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSrvvcmIEWPEH-------PNRTYEKAYHICVTVLIYF 206
Cdd:cd15382  103 ILKPLRLSDARRRGRIMLAVAWVISFLCSIPQSFIFHVESHPC-----VTWFSQcvtfnffPSHDHELAYNIFNMITMYA 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 207 LPLLVIGYAYTVVgitLWasEIPGDSS---DRYHEQVS--------------AKRKVVKMMIVVVCTFAICWLPFHIFFL 269
Cdd:cd15382  178 LPLIIIVFCYSLI---LC--EISRKSKekkEDVSEKSSsvrlrrssvgllerARSRTLKMTIVIVLVFIICWTPYFIMSL 252
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568941324 270 LPYINPDLYLK--KFIQQvylaSMWL-AMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15382  253 WYWFDRESASKvdPRIQK----GLFLfAVSNSCMNPIVYGYFSIDLR 295
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
54-316 4.83e-13

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 69.49  E-value: 4.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTV---TNYFLVNLAFAEACMAAFNTVV---NFTYaVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVA 127
Cdd:cd15355   22 LYTLARKKSLQHLqstVHYHLASLALSDLLILLLAMPVelyNFIW-VHHPWAFGDAACRGYYFLRDACTYATALNVASLS 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 128 FDRYMAIIHPLQPR--LSATATKVVIFVIWVLALLLAFP----QGYYSTTETMPSRVVCMIEWPEHPNRTYekayhICVT 201
Cdd:cd15355  101 VERYLAICHPFKAKslMSRSRTKKFISAIWLASALLAIPmlftMGEQNRSGTHPGGLICTPIVDTSTLKVV-----IQVN 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 202 VLIYFL-PLLVIGYAYTVVG-----------------------ITLWASEIPGdssdryheQVSAKRKVVKMMIVVVCTF 257
Cdd:cd15355  176 AFLSFLfPMLVISVLNTLIAnqltvmvnqaeqenqvctiggqrTVLSVSMEPG--------RVQSLRHGVLVLRAVVIAF 247
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568941324 258 AICWLPFHI----FFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15355  248 VVCWLPYHVrrlmFCYVSDEQWTTFLYDFYHYFYMLTNVLFYVSSAINPILYNLVSANFRQIF 310
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
39-316 5.15e-13

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 69.00  E-value: 5.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  39 YTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACmaaFNTVVNFTYAVH--NVWYYGLFYCKFHNFFPIAAL 116
Cdd:cd15087    7 YSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDL---FTLVLPINIAEHllQQWPFGELLCKLILSIDHYNI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 117 FASIYSMTAVAFDRYMAIIHPLQPRLSA----TATKVVIFVIWVLALLLAFP----QGYYSTTETMPSrvvCMIEWPeHP 188
Cdd:cd15087   84 FSSIYFLTVMSVDRYLVVLATVRSRRMPyrtyRAAKIVSLCVWLLVTIIVLPftvfAGVYSNELGRKS---CVLSFP-SP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 189 NRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWAseIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFaiCWLPFHIFF 268
Cdd:cd15087  160 ESLWFKASRIYTLVLGFAIPVSTICILYTMMLYKLRN--MRLNSNAKALDKAKKKVTLMVLVVLAVCLF--CWTPFHLST 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568941324 269 LLPyINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15087  236 VVA-LTTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
56-316 5.27e-13

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 68.92  E-value: 5.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAH-KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAI 134
Cdd:cd15312   23 ISISHfKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHLCFIAVDRYYAV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 135 IHPLQPRLSAT--ATKVVIFVIWVLALLLAF----PQGYYSTTETMPSRVVCMIEWPehpnRTYEKAYHICVTVLIYFLP 208
Cdd:cd15312  103 CDPLHYRTKITtpVIKVFLVISWSVPCLFAFgvvfSEVNLEGIEDYVALVSCTGSCV----LIFNKLWGVIASLIAFFIP 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIGYAYtvVGITLWA-------SEIPGDSSDRYHEQVSAKRKVVKMMIVVVC--TFAICWLPFHIFFLL-PYIN---P 275
Cdd:cd15312  179 GTVMIGIY--IKIFFVArkhakviNNRPSVTKGDSKNKLSKKKERKAAKTLSIVmgVFLLCWLPFFVATLIdPFLNfstP 256
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 568941324 276 DLylkkfiqqVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15312  257 VD--------LFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
54-313 8.44e-13

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 68.32  E-value: 8.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15077   22 IICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVSLWSLAVVAFERFLV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQpRLSATATKVVIFVI--WVLALLLAFPQgYYSTTETMPSRVVCMI--EWPEHPNRTYEKAYHICVTVLIYFLPL 209
Cdd:cd15077  102 ICKPLG-NFTFRGTHAIIGCIatWVFGLAASLPP-LFGWSRYIPEGLQCSCgpDWYTTNNKWNNESYVMFLFCFCFGVPL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVGITLWASEIPGDSSDRYHEqvsAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINpdlylKKFIQQVYLA 289
Cdd:cd15077  180 SIIVFSYGRLLLTLRAVAKQQEQSASTQK---AEREVTKMVVVMVLGFLVCWLPYASFALWVVTN-----RGEPFDLRLA 251
                        250       260
                 ....*....|....*....|....*.
gi 568941324 290 SM--WLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15077  252 SIpsVFSKASTVYNPVIYVFMNKQFR 277
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
62-313 8.88e-13

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 68.30  E-value: 8.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  62 RMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHP--LQ 139
Cdd:cd15339   29 RKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDTCNQFACSAIMTAMSLDRYIALVHPfrLT 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 140 PRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRV-VCMIEWpEHPNRTYekAYHICVTVLIYFLPLLVIGYAYTV 218
Cdd:cd15339  109 SLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLeSCAFNL-TSPDDVL--WYTLYQTITTFFFPLPLILICYIL 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 219 VGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCT--FAICWLPFHIFFLLPYINPDLYLKKFIQqvYLASMWLAMS 296
Cdd:cd15339  186 ILCYTWEMYRKNKKAGRYNTSIPRQRVMRLTKMVLVLVgvFLVSAAPYHVIQLVNLSVSQPTLAFYVS--YYLSICLSYA 263
                        250
                 ....*....|....*..
gi 568941324 297 STMYNPIIYCCLNDRFR 313
Cdd:cd15339  264 SSSINPFLYILLSGNFR 280
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
63-313 8.94e-13

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 67.94  E-value: 8.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  63 MRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPlQPRL 142
Cdd:cd15404   31 MRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFFWLFVMEGVAILLIISIDRFLIIVQK-QDKL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 143 SATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRV-VCMIEWPEHPNRtyeKAYHICVTVLIYFLPLLVIGYAYTVVGI 221
Cdd:cd15404  110 NPYRAKVLIAVSWAVSFCVAFPLAVGSPDLQIPSRApQCVFGYTTNPGY---QAYVILIMLIFFFIPFMVMLYSFMGILN 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 222 TLwaseipgdssdryheqVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYN 301
Cdd:cd15404  187 TV----------------RSFKTRAFTTILILFIVFTVCWAPFTTYSLVATFNSHFYHKHNFFEISTWLLWLCYLKSALN 250
                        250
                 ....*....|..
gi 568941324 302 PIIYCCLNDRFR 313
Cdd:cd15404  251 PLIYYWRIKKFR 262
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
36-316 1.04e-12

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 67.64  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  36 AAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAA 115
Cdd:cd15321   10 AAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 116 LFASIYSMTAVAFDRYMAIIHPLQ--PRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEhpnrtyE 193
Cdd:cd15321   90 CTSSIVHLCAISLDRYWSVSRAIEynSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLPQCKLNE------E 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 194 KAYHICVTVLIYFLPLLVIGYAYTVVgitlwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYI 273
Cdd:cd15321  164 AWYILSSSIGSFFAPCLIMILVYLRI----------------YLIAKNREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAI 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568941324 274 NPDLYlkKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15321  228 CPELC--KVPHSLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
54-313 1.15e-12

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 67.86  E-value: 1.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15373   22 LYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRFLFYTNLYCSILFLLCISVHRFLG 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPR--LSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCmiewpeHPNRTYEK-----AYHICVTVLIYF 206
Cdd:cd15373  102 VCYPVRSLrwLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITC------HDTSSPELfdqfvVYSSVMLVLLFC 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 207 LPLLVIGYAYTVVGITLWASEIPGDSSDRyheqvsAKRKVVKMMIVVVCTFAICWLPFHI----FFLLPYINPDLYLKKF 282
Cdd:cd15373  176 VPFVVILVCYALMVRKLLKPSAGTSTNSR------SKKKSVKMIIIVLAVFILCFLPFHVtrtlYYSFRSMDLSCGTLNA 249
                        250       260       270
                 ....*....|....*....|....*....|.
gi 568941324 283 IQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15373  250 INLAYKVTRPLASANSCLDPILYFLAGQSFR 280
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
54-309 1.31e-12

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 67.87  E-value: 1.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVH-NVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd15212   22 IGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSrPGWLFGDRLCLANGFFNACFGIVSTLTMTLISFDRYY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVV---CMIEWPEHPNRTyEKAYHICVTVLIYFLPL 209
Cdd:cd15212  102 AIVRQPQGKIGRRRALQLLAAAWLTALGFSLPWYLLASAPEYYEKLGfyhCLYVLHSGPSRL-GAAYSSVLIVLCYLLPF 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVGITLWASEI-------PGDSSDRYHEQVSAKRKVVKMMIvvvctFAICWLPFHIFFLLPYINPdlylKKF 282
Cdd:cd15212  181 ALMCFCHYNICKTVRLSESrvrpvttYAHLLRFYSEMRTATTVLIMIVF-----IICCWGPYCLLGLVAAAGG----YQF 251
                        250       260
                 ....*....|....*....|....*..
gi 568941324 283 IQQVYLASMWLAMSSTMYNPIIYCCLN 309
Cdd:cd15212  252 PPLMDTVAIWMAWANGAINPLIYAIRN 278
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
55-316 1.51e-12

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 67.65  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  55 WIILAHKRMRTVTNYFLVNLAFAEACMAAFntVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAI 134
Cdd:cd15069   23 AAVGTNSTLQTPTNYFLVSLAAADVAVGLF--AIPFAITISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 135 IHPLQPRLSATATKV--VIFVIWVLALLLAFPQ--GYYSTTETMPSrvvCMIEWPEHPNRT-------YEKAyhICVTVL 203
Cdd:cd15069  101 KVPLRYKSLVTGKRArgVIAVLWVLAFGIGLTPflGWNKAMSATNN---STNPADHGTNHScclisclFENV--VPMSYM 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 204 IYF-------LPLLVIGYAYTVVGIT----LWASEIPGDSSDRYHEQVSAKRKVVKMMIVvvctFAICWLPFHIFFLLPY 272
Cdd:cd15069  176 VYFnffgcvlPPLLIMLVIYIKIFLVacrqLQRTELMDHSRTTLQREIHAAKSLAIIVGI----FALCWLPVHILNCITL 251
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568941324 273 INPDLYLKKFIQQVYLASMwLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15069  252 FQPEFSKSKPKWAMNVAIL-LSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
56-313 1.57e-12

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 67.57  E-value: 1.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:cd15403   24 IVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYWFFVLEGVAILLIISVDRFLIIV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HPlQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRV-VCMIEWPEHPNrtyEKAYHICVTVLIYFLPLLVIGY 214
Cdd:cd15403  104 QR-QDKLNPHRAKVMIAISWVLSFCISFPSVVGWTLVEVPARApQCVLGYTESPA---DRVYAVLLVVAVFFVPFSIMLY 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 215 AYTVVGITLW--ASEIPGDSSDRYHEQVSA------------------KRKVVKMMIVVVCTFAICWLPFHIFFLLPYIN 274
Cdd:cd15403  180 SYLCILNTVRrnAVRIHNHADSLCLSQVSKlglmglqrphqmnvdmsfKTRAFTTILILFVGFSLCWLPHTVFSLLSVFS 259
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568941324 275 PDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15403  260 RRFYYSSSFYPISTCVLWLSYLKSVFNPVIYCWRIKKFR 298
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
57-305 1.62e-12

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 67.32  E-value: 1.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEaCMAAFNtvvnFTYAVHNVWYYGLFYCKFHNFFP----IAALFASIYSMTAVAFDRYM 132
Cdd:cd14972   23 IIKNRRLHKPMYILIANLAAAD-LLAGIA----FVFTFLSVLLVSLTPSPATWLLRkgslVLSLLASAYSLLAIAVDRYI 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPL--QPRLSATATKVVIFVIWVLALLLA--FPQGYYSTTETMPSrvvCMIEWPehpnrTYEKAYHICVTVlIYFLP 208
Cdd:cd14972   98 SIVHGLtyVNNVTNKRVKVLIALVWVWSVLLAllPVLGWNCVLCDQES---CSPLGP-----GLPKSYLVLILV-FFFIA 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIGYAYTVVGITLW--ASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDlylKKFIQQV 286
Cdd:cd14972  169 LVIIVFLYVRIFWCLWrhANAIAARQEAAVPAQPSTSRKLAKTVVIVLGVFLVCWLPLLILLVLDVLCPS---VCDIQAV 245
                        250
                 ....*....|....*....
gi 568941324 287 YLASMWLAMSSTMYNPIIY 305
Cdd:cd14972  246 FYYFLVLALLNSAINPIIY 264
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
39-313 1.86e-12

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 67.20  E-value: 1.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  39 YTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEaCMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFA 118
Cdd:cd15183    7 YSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISD-LVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 119 SIYSMTAVAFDRYMAIIHPLQPRLSATATKVVI--FVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAY 196
Cdd:cd15183   86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIItsIITWALAILASMPCLYFFKSQWEFTHHTCSAHFPRKSLIRWKRFQ 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 197 HICVTVLIYFLPLLVIGYAYTvvGITLWASEIPGDssdryhEQVSAKRKVVKMMIVvvctFAICWLPFHIFFLLPYINPD 276
Cdd:cd15183  166 ALKLNLLGLILPLLVMIICYT--GIINILLRRPNE------KKAKAVRLIFVITLL----FFLLWTPYNLAAFVSAFQDV 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 568941324 277 LYLKKFIQ--QVYLASM---WLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15183  234 LFTPSCEQsqQLDLALQvteVIAYTHCCVNPVIYVFVGERFR 275
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
54-305 2.43e-12

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 66.75  E-value: 2.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRmRTVTNYFLVNLAFAEacMAAFNTVVNFTY--AVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRY 131
Cdd:cd15118   22 LWVVGFRLR-RTVISIWILNLALSD--LLATLSLPFFTYylASGHTWELGTTFCRIHSSIFFLNMFVSGFLLAAISLDRC 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 132 MAIIHPL--QPRLSATATKVVIFVIWVLALLLAFPQGYY-STTETMPSRVVCMIEW----PEHPNR-----TYEKAYHIC 199
Cdd:cd15118   99 LLVVKPVwaQNHRNVAAAKKICGVIWAMALINTIPYFVFrDVIERKDGRKLCYYNFalfsPSPDNNhpickQRQEGLAIS 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 200 VTVLIYFLPLLVIGYAYTVVGITLwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLY- 278
Cdd:cd15118  179 KLLLAFLIPLVIIAVSYAVVSLII------------RHRCRRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEVMAHNQHs 246
                        250       260
                 ....*....|....*....|....*..
gi 568941324 279 LKKFIQQVYLASMWLAMSSTMYNPIIY 305
Cdd:cd15118  247 LRPLVIQGLPFATTLAFLNSVLNPVLY 273
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
54-313 4.58e-12

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 65.85  E-value: 4.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAE---ACMAAFNTVVNftyavHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15182   22 LWILVKYEKLKTLTNIFILNLAISDllfTFTLPFWASYH-----SSGWIFGEILCKAVTSIFYIGFYSSILFLTLMTIDR 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQPRLSATA--TKVVIFVIWVLALLLAFPqgYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHicvTVLIYFLP 208
Cdd:cd15182   97 YLAVVHPLSALRSRKLryASLVSVAVWVISILASLP--ELILSTVMKSDEDGSLCEYSSIKWKLGYYYQ---QNLFFLIP 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIGYAYTVVGITLWASEipgdsSDRYHEQVSakrkvvkMMIVVVCTFAICWLPFHIFFLL----PYINPDLYLKKFIQ 284
Cdd:cd15182  172 LGIIVYCYVRILQTLMRTR-----TMRKHRTVK-------LIFVIVLVFFLSWAPYNIVIFLrslkDLTIPICECSKQLD 239
                        250       260
                 ....*....|....*....|....*....
gi 568941324 285 QVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15182  240 YAFYICRNIAFSHCCLNPVFYVFVGVKFR 268
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
54-316 5.32e-12

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 65.74  E-value: 5.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15322   22 IIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWS 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKV--VIFVIWVLALLLAFPQGYYSTTET-MPSRVVCMIewpehpnrTYEKAYHICVTVLIYFLPLL 210
Cdd:cd15322  102 ITQAIEYNLKRTPRRIkcIIFIVWVISAVISFPPLITIEKKSgQPEGPICKI--------NDEKWYIISSCIGSFFAPCL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVgitlwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYIN----PDLYLKKFiqqv 286
Cdd:cd15322  174 IMVLVYIRI----------------YQIAKNREKRFTFVLAVVIGVFVICWFPFFFTYTLTAVCdcsvPETLFKFF---- 233
                        250       260       270
                 ....*....|....*....|....*....|
gi 568941324 287 ylasMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15322  234 ----FWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
54-316 8.76e-12

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 64.95  E-value: 8.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15335   22 IAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALDRYWA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATK--VVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIewpEHPNRTYEkayhICVTVLIYFLPLLV 211
Cdd:cd15335  102 ITDAIEYARKRTAKRagLMILTVWTISIFISIPPLFWRNHHDANIPSQCII---QHDHVIYT----IYSTFGAFYIPLTL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTvvgitlwaseipgdssdRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLpyinPDLYLKKFIQQVYLASM 291
Cdd:cd15335  175 ILILYY-----------------RIYHAASRERKAARILGLILGAFILSWLPFFIKELI----VGLSVMTVSPEVADFLT 233
                        250       260
                 ....*....|....*....|....*
gi 568941324 292 WLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15335  234 WLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
54-313 1.02e-11

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 64.95  E-value: 1.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACM-------AAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAV 126
Cdd:cd14980   23 IWHISSKKKKKKVPKLLIINLAIADFLMgiylliiAIADQYYRGRYAQYSEEWLRSPPCLLACFLVSLSSLMSVLMMLLI 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 127 AFDRYMAIIHPLQP-RLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRV-----VCMiewPEHPNRTYEKAYHICV 200
Cdd:cd14980  103 TLDRYICIVYPFSNkRLSYKSAKIILILGWLFSIIFAAIPILYSINQPGDNRLygyssICM---PSNVSNPYYRGWLIAY 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 201 TVLIyFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMivvvcTFAICWLPFHIFFLLPYINP---DL 277
Cdd:cd14980  180 LLLT-FIAWIIICILYILIFISVRKSRKSARRSSSKRDKRIAIRLALILI-----TDLICWLPYYIVIFSGLLTSteiDI 253
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568941324 278 YLKKFIqqVYLAsmwLAMSSTMyNPIIYCCLNDRFR 313
Cdd:cd14980  254 HVLQFI--AILA---LPLNSAI-NPYLYTLTTPTFK 283
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
54-313 1.10e-11

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 64.71  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAE---ACMAAFntVVNFTYAVHNvWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15160   22 LWVLYLQIKKENVLGVYLLNLSLSDllyILTLPL--WIDYTANHHN-WTFGPLSCKVVGFFFYTNIYASIGFLCCIAVDR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQP---RLSATATKVVIfVIWVLALLL-AFPQGYYSTTETMPSRVVCmieWPEHPNRTYEKAYHICVTVLIYF 206
Cdd:cd15160   99 YLAVVHPLRFrglRTRRFALKVSA-SIWVLELGThSVFLGHDELFRDEPNHTLC---YEKYPMEGWQASYNYARFLVGFL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 207 LPLLVIGYAYTVVGITLWASeiPGDSSDRyheqvsaKRKVVKMMIVVVCTFAICWLPFHIFFLLPYI-----NPDLYLKK 281
Cdd:cd15160  175 IPLSLILFFYRRVLRAVRQS--PSLEREE-------KRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVielvqNGLCGFEK 245
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568941324 282 FIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15160  246 RVFTAYQISLCLTSLNCVADPILYIFVTEDVR 277
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
41-316 1.18e-11

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 65.06  E-value: 1.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  41 VIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASI 120
Cdd:cd15065    8 LIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 121 YSMTAVAFDRYMAIIHPLQ--PRLSATATKVVIFVIWVLALLLAF---PQGYYSTTE--------TMPSRVVCMIEWPeh 187
Cdd:cd15065   88 LNLCAISLDRYIHIKKPLKyeRWMTTRRALVVIASVWILSALISFlpiHLGWHRLSQdeikglnhASNPKPSCALDLN-- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 188 pnrtyeKAYHICVTVLIYFLPLLVIGYAYT---------VVGI-TLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVC-- 255
Cdd:cd15065  166 ------PTYAVVSSLISFYIPCLVMLLIYSrlylyarkhVVNIkSQKLPSESGSKFQVPSLSSKHNNQGVSDHKAAVTlg 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941324 256 ----TFAICWLPFHIffllpyINPDLYLKK--FIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15065  240 iimgVFLICWLPFFI------INIIAAFCKtcIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
60-316 1.41e-11

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 64.78  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  60 HKRMRTVTNYFLVNLAFAEACMAAfnTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ 139
Cdd:cd15172   28 YKRTKSMTDVYLLNMAIADILFVL--TLPFWAVYEAHQWIFGNFSCKLLRGIYAINFYSGMLLLACISVDRYIAIVQATK 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 140 P-RLSATA---TKVVIFVIWVLALLLAFPQGYYSTT--ETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLI-YFLPLLVI 212
Cdd:cd15172  106 SfRLRSRTlaySKLICAAVWLLAILISLPTFIFSEVydFGLEEQYVCEPKYPKNSTAIMWKLLVLSLQVSLgFFIPLLVM 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 213 GYAYTVVGITLwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYL----KKFIQQVYL 288
Cdd:cd15172  186 IFCYSFIIKTL------------LQAQNSQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEAINLGEQQscssEKAVAYAKT 253
                        250       260
                 ....*....|....*....|....*...
gi 568941324 289 ASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15172  254 ITECLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
35-313 1.53e-11

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 64.38  E-value: 1.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  35 WAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAE---ACMAAFNTVvnftYAVHN-VWYYGLFYCKFHNF 110
Cdd:cd15158    3 YSTLYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDllcVCTLPLRVV----YYVHKgQWLFGDFLCRISSY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 111 FPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATK--VVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMiEWPEHP 188
Cdd:cd15158   79 ALYVNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKarIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKCF-EPPQSN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 189 -NRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWAseipgdSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHI- 266
Cdd:cd15158  158 qQLTKLLVLNYISLVVGFIIPFLVILICYAMIIRTLLK------NTMKARKQQSSRKKAIRMIIIVLLAFLVSFMPYHIq 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568941324 267 -----FFLLPYINPDLYlKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15158  232 rtihlHFLSRKDSTCEE-VLYMQKSVVITLCLAAANCCFDPLLYFFSGENFR 282
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
34-316 1.69e-11

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 64.56  E-value: 1.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  34 LWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEaCMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPI 113
Cdd:cd15155    2 LYGAVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSD-LLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 114 AALFASIYSMTAVAFDRYMAIIHPLQPRLSATA--TKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRT 191
Cdd:cd15155   81 TNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRrnSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKSIWKT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 192 YEKAYHICVTVLIYFLPLLVIGYAYTVVGITLwasEIPGDSSdryhEQVSAKRKVVKMMIVVVCTFAICWLPFH-IFFLL 270
Cdd:cd15155  161 YLSKITIFIEVVGFIIPLLLNLTCSSLVLRTL---RKPATLS----QIGTNKEKVLKMILVHVAIFVVCFVPYNsILFLY 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 568941324 271 PYIN----PDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15155  234 ALVRsqaiANCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
56-314 2.97e-11

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 63.65  E-value: 2.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAfnTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:cd15188   25 LLLYVPKKKKMTEVYLLNLAVSDLLFLV--TLPFWAMYVAWHWVFGSFLCKFVSTLYTINFYSGIFFVSCMSLDKYLEIV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HPLQPRLSATATK--VVIFVIWVLALLLAFPQGYYSTT-ETMPSRVVCMIEWPEHpNRTYEKAYHICVTVLIYFLPLLVI 212
Cdd:cd15188  103 HAQSPHRLRTRRKslLVLVAVWVLSIALSVPDMVFVQThHTNNGVWVCHADYGGH-HTIWKLVFQFQQNLLGFLFPLLAM 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 213 GYAYTVVGITLWASEIPGdssdryheqvsaKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINpDLYL------KKFIQQV 286
Cdd:cd15188  182 VFFYSRIACVLTRLRPPG------------QGRALRFVAALVVVFFVLWFPYNLTLFLHSLQ-DLHVigncerSRHLDYA 248
                        250       260
                 ....*....|....*....|....*...
gi 568941324 287 YLASMWLAMSSTMYNPIIYCCLNDRFRL 314
Cdd:cd15188  249 LQVTESLAFVHCCLNPLLYAFVSKRFRL 276
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
60-316 3.09e-11

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 63.51  E-value: 3.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  60 HKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ 139
Cdd:cd15300   28 NSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLT 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 140 PRLSATATK--VVIFVIWVLALLLAFPQ----GYYSTTETMPSRvVCMIEWPEHPNRTYEKAyhicvtVLIYFLPLLVIG 213
Cdd:cd15300  108 YRAKRTPKRagIMIGLAWLISFILWAPPilcwQYFVGKRTVPER-ECQIQFLSEPTITFGTA------IAAFYIPVSVMT 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 214 YAYTvvgitlwaseipgdssdRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYlasmWL 293
Cdd:cd15300  181 ILYC-----------------RIYKETIKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCSDCIPLTLWHLGY----WL 239
                        250       260
                 ....*....|....*....|...
gi 568941324 294 AMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15300  240 CYVNSTVNPMCYALCNKTFRKTF 262
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
54-313 3.24e-11

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 63.68  E-value: 3.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15076   22 LFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTGWSLAFLAFERYIV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQP-RLSATATKVVIFVIWVLALLLAFPQgYYSTTETMPS--RVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLL 210
Cdd:cd15076  102 ICKPFGNfRFGSKHALGAVVATWIIGIGVSLPP-FFGWSRYIPEglQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIVPLS 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLWASEIPGDSSDRYHEqvsAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKkfIQQVYLAS 290
Cdd:cd15076  181 IIIFSYSQLLGALRAVAAQQQESASTQK---AEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGLD--LRLVTIPA 255
                        250       260
                 ....*....|....*....|...
gi 568941324 291 mWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15076  256 -FFSKSSCVYNPIIYCFMNKQFR 277
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
54-273 3.34e-11

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 63.51  E-value: 3.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEacmaafnTVVNFT-----YAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAF 128
Cdd:cd15165   22 LWVFLFKIKKWTESTIYMINLALND-------LLLLLSlpfkmHSSKKQWPLGRTLCSFLESLYFVNMYGSILIIVCISV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 129 DRYMAIIHPLQ-PRL-SATATKVVIFVIWVLALLLAFPqgYYSTTETMPSRVVCmieWPEHPNRTYEKAYHICVTVLIYF 206
Cdd:cd15165   95 DRYIAIRHPFLaKRLrSPRKAAIVCLTIWVFVWAGSIP--IYSFHDKPTNNTRC---FHGFSNKTWSKKVIVVVEEFGFL 169
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941324 207 LPLLVIGYAYTVVGITLWASEIPGDSsdryHEQVSAKRKVVKMMIVvvcTFAICWLPFHIFFLLPYI 273
Cdd:cd15165  170 IPMAVMVFCSVQIIRTLLDMRRPEQP----KVKQNKSVKIVLSNLV---VFLVCFTPYHLGIFLQFL 229
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
61-320 4.00e-11

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 62.92  E-value: 4.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQP 140
Cdd:cd15295   29 KNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLCTASVYNIVLISYDRYQSVSNAVSY 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 141 RLSATAT-KVVIFV--IWVLALLLAFPQGYYSTTETmpsrvvcmIEWPEHPNRTYEKAYHI-CVTVLIYFLPLLVIGYAY 216
Cdd:cd15295  109 RNQQTATlRIVTQMvaVWVLAFLVHGPAILVSDSWK--------TEDGECEPEFFSNWYILaITSVLEFLVPVILVAYFN 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 217 TVVGITLWAseipgdssdRYHEQVSAKRKVVKMMivvvcTFAICWLPFHIFfllpYINPDLYLKKFIQQVYLASMWLAMS 296
Cdd:cd15295  181 TQIYWSLWK---------RLRDRKLAKSLAIILG-----TFAICWAPYSLF----TIIRAACEKHRGSPWYNFAFWLQWF 242
                        250       260
                 ....*....|....*....|....
gi 568941324 297 STMYNPIIYCCLNDRFRLGFKHAF 320
Cdd:cd15295  243 NSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
61-316 4.12e-11

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 62.83  E-value: 4.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ- 139
Cdd:cd15050   29 RKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKy 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 140 -PRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVcmiewpehPNRTYEKAYH------ICVTVLIYFLPLLVI 212
Cdd:cd15050  109 lKYRTKTRASLMISGAWLLSFLWVIPILGWHHFARGGERVV--------LEDKCETDFHdvtwfkVLTAILNFYIPSLLM 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 213 GYAYTVVgitlwaseipgdssdrYHEqVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLylkkFIQQVYLASMW 292
Cdd:cd15050  181 LWFYAKI----------------FKA-VNRERKAAKQLGFIMAAFILCWIPYFILFMVIAFCKNC----CNENLHMFTIW 239
                        250       260
                 ....*....|....*....|....
gi 568941324 293 LAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15050  240 LGYINSTLNPFIYPLCNENFKKTF 263
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
54-313 4.52e-11

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 63.23  E-value: 4.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd14991   22 LWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNLFMLSVNRSASIAFLTAVALDRYFK 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQP--RLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVC----MIEWPEHPNRTYEKAYhicvtVLIYFL 207
Cdd:cd14991  102 VVHPHHRvnRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSChsfsSYTKPSLSIRWHNALF-----LLEFFL 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 208 PLLVIGYAYTVVGITLWASEIPGdssdryhEQVSAKRKVVKMMIVVVcTFAICWLPFHIFFLLPYINPDLYLKK---FIQ 284
Cdd:cd14991  177 PLGLIVFCSVRIACNLRIRQSLG-------KQARVQRAIRLVFLVVI-VFVLCFLPSIIAGLLALVFKNLGSCRclnSVA 248
                        250       260
                 ....*....|....*....|....*....
gi 568941324 285 QVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd14991  249 QLFHISLAFTYLNSALDPVIYCFSSPWFR 277
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
58-313 4.88e-11

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 62.87  E-value: 4.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  58 LAHKRMRTVTNYFLVNLAFAEACMAAfnTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH- 136
Cdd:cd15177   26 TRYRRLRSMTDVYLLNLALADLLLLL--TLPFAAAETLQGWIFGNAMCKLIQGLYAINFYSGFLFLTCISVDRYVVIVRa 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPRLSATA---TKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIG 213
Cdd:cd15177  104 TSAHRLRPKTlfySVLTSLIVWLLSILFALPQLIYSRVENRSELSSCRMIFPEVVSRTVKGATALTQVVLGFAIPLIVMA 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 214 YAYTVVGITLwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQ------VY 287
Cdd:cd15177  184 VCYAAIGRTL------------LAARGWERHRALRVIAALVVAFVLFQLPYSVVLLLDTADLLATLELSCSQskrkdiAL 251
                        250       260
                 ....*....|....*....|....*.
gi 568941324 288 LASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15177  252 LVTSGLAYVRCCLNPLLYAFVGVRFR 277
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
30-316 5.19e-11

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 62.89  E-value: 5.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  30 WQIVLwAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHN 109
Cdd:cd15333    3 LKISL-AVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 110 FFPIAALFASIYSMTAVAFDRYMAIIHPLQ--PRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEwpeh 187
Cdd:cd15333   82 SSDITCCTASILHLCVIALDRYWAITDAVEysKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVN---- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 188 pnrTYEKAYHICVTVLIYFLPllvigyayTVVGITLWASeipgdssdRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIF 267
Cdd:cd15333  158 ---TDHILYTVYSTVGAFYIP--------TLLLIALYGR--------IYVEARARERKATKTLGIILGAFIVCWLPFFII 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 568941324 268 FLLPYINPDLYLKKFIQQVYLAsmWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15333  219 SLVLPICKDACWFHLAIFDFFT--WLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
57-313 7.21e-11

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 62.57  E-value: 7.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15316   25 ILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFCYASLFHLCFISVDRYIAVTD 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PL--QPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYhICVTVLIYFLPLLVIGY 214
Cdd:cd15316  105 PLvyPTKFTVSVSGICISVSWIFSLTYSFSVFYTGVNDDGLEELVNALNCVGGCQIILNQNW-VLVDFLLFFIPTFAMII 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 215 AYT---------VVGITLWASEIPgDSSDRYHEQVSAK-RKVVKMMIVVVCTFAICWLPFHIFFL----LPYINPDLylk 280
Cdd:cd15316  184 LYGkiflvakqqARKIEMTSSKAE-SSSESYKDRVARReRKAAKTLGITVIAFLVSWLPYLIDVLidafMNFITPPY--- 259
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568941324 281 kfiqqVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15316  260 -----IYEICCWCAYYNSAMNPLIYALFYPWFR 287
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
37-223 7.59e-11

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 62.48  E-value: 7.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  37 AAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAfnTVVNFTYAVHNVWYYGLFYCKFHNFFPIAAL 116
Cdd:cd15175    5 AMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLL--TLPFWAASAAKKWVFGEEMCKAVYCLYKMSF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 117 FASIYSMTAVAFDRYMAII-----HPLQPRlSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEwpEHPNRT 191
Cdd:cd15175   83 FSGMLLLMCISIDRYFAIVqaasaHRHRSR-AVFISKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTCSIF--TNNKQT 159
                        170       180       190
                 ....*....|....*....|....*....|..
gi 568941324 192 YEKAYHICVTVLIYFLPLLVIGYAYTVVGITL 223
Cdd:cd15175  160 LSVKIQISQMVLGFLVPLVVMSFCYSVIIKTL 191
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
57-316 1.18e-10

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 61.49  E-value: 1.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15323   25 VLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCAISLDRYWSVTQ 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPRLSATATKV--VIFVIWVLALLLAFPQgyysttetmpsrVVCMIEWPEHPNRTY-----EKAYHICVTVLIYFLPL 209
Cdd:cd15323  105 AVEYNLKRTPRRVkaIIVTVWLISAVISFPP------------LISMYRDPEGDVYPQcklndETWYILSSCIGSFFAPC 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVgitlwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLL------PYINPDLYLKKFi 283
Cdd:cd15323  173 LIMILVYIRI----------------YRVAKAREKRFTFVLAVVMGVFVVCWFPFFFSYSLygicreACEVPEPLFKFF- 235
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568941324 284 qqvylasMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15323  236 -------FWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
33-313 1.25e-10

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 61.80  E-value: 1.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTV---TNYFLVNLAFAEACMAAFNTVV---NFTYaVHNVWYYGLFYCK 106
Cdd:cd15356    1 VLFTAVYALIWALGAAGNALTIHLVLKKRSLRGLqgtVHYHLVSLALSDLLILLISVPIelyNFVW-FHYPWVFGDLVCR 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 107 FHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPR--LSATATKVVIFVIWVLALLLAFP------QGYYSTT---ETMP 175
Cdd:cd15356   80 GYYFVRDICSYATVLNIASLSAERYLAICQPLRAKrlLSKRRTKWLLALIWASSLGFALPmafimgQKYELETadgEPEP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 176 SRVVCMIewpeHPNRTYEKAYhICVTVLIYF-LPLLVIGYAYTVVGitlwaseipgdssdrYHEQVSAKRKVVKMMIVVV 254
Cdd:cd15356  160 SSRVCTV----LVSRATLKVF-IQVNAFVSFvLPLALIAFLNGVTV---------------SHLRIQSLQHSVQVLRAIV 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568941324 255 CTFAICWLPFHIFFLL-PYINPDLY---LKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15356  220 IAYVICWLPYHARRLMfCYVPDDAWtdsLYNFYHYFYMLTNTLFYVSSAVNPLLYNVVSSSFR 282
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
55-316 1.34e-10

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 61.88  E-value: 1.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  55 WIILAHKRMRTVTNYFLVNLAFAEACMAAFntVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAI 134
Cdd:cd15068   23 WAVWLNSNLQNVTNYFVVSLAAADIAVGVL--AIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 135 IHPLQ--PRLSATATKVVIFVIWVLALLLAF-----------PQGYYSTTETMPS-RVVCMIEWPEHPNRTYEKAYHICV 200
Cdd:cd15068  101 RIPLRynGLVTGTRAKGIIAICWVLSFAIGLtpmlgwnncgqPKEGKNHSQGCGEgQVACLFEDVVPMNYMVYFNFFACV 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 201 TVliyflPLLVIGYAYTVVGIT----LWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHI-----FFLLP 271
Cdd:cd15068  181 LV-----PLLLMLGVYLRIFLAarrqLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIincftFFCPD 255
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 568941324 272 YINPDLYLkkfiqqVYLASMwLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15068  256 CSHAPLWL------MYLAIV-LSHTNSVVNPFIYAYRIREFRQTF 293
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
54-321 1.67e-10

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 62.34  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMaafntVVNFTYAVHN---VWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:PHA02638 119 IIMILFCKKIKTITDIYIFNLAISDLIF-----VIDFPFIIYNefdQWIFGDFMCKVISASYYIGFFSNMFLITLMSIDR 193
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQPRLSATATKVVIFVI--WVLALLLAFPQGYY-----------STTETMPSRVVCMIEWPEHPNRTY-EKAY 196
Cdd:PHA02638 194 YFAILYPISFQKYRTFNIGIILCIisWILSLIITSPAYFIfeasniifsaqDSNETISNYQCTLIEDNEKNNISFlGRIL 273
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 197 HICVTVLIYFLPLLVIGYAYTVVGITLwaseipgdssdRYHEQVSAKRKVVKMMIVVVCTFaICWLPFHIFFLLPYINP- 275
Cdd:PHA02638 274 QFEINILGMFIPIIIFAFCYIKIILKL-----------KQLKKSKKTKSIIIVSIIIICSL-ICWIPLNIVILFATMYSf 341
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568941324 276 -------DLYLKKFIQQVYLASMWLAMSST--MYNPIIYCCLNDRFRLGFKHAFR 321
Cdd:PHA02638 342 kgfnsiiSEHICGFIKLGYAMMLAEAISLThcCINPLIYTLIGENFRMHLLMIFR 396
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
57-316 2.40e-10

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 60.92  E-value: 2.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15317   25 ISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTTSIFHLCFIAIDRYYAVCD 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQ--PRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMpsrvvcMIEWPEHPN-----RTYEKAYHICVTVLIYFLPL 209
Cdd:cd15317  105 PLRypSKITVQVAWRFIAIGWLVPGIYTFGLIYTGANDEG------LEEYSSEIScvggcQLLFNKIWVLLDFLTFFIPC 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYT---------VVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLL-PYINpdlyl 279
Cdd:cd15317  179 LIMIGLYAkiflvarrqARKIQNMEDKFRSSEENSSKASASRERKAAKTLAIVMGIFLFCWLPYFIDTIVdEYSN----- 253
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568941324 280 kkFIQQ--VYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15317  254 --FITPaiVFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
93-217 2.84e-10

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 60.84  E-value: 2.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  93 AVHNV---WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQG--Y 167
Cdd:cd15383   59 AAWNVtvqWYAGDLACRLLMFLKLFAMYSSAFVTVVISLDRHAAILNPLAIGSARRRNRIMLCAAWGLSALLALPQLflF 138
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568941324 168 YSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYT 217
Cdd:cd15383  139 HTVTATPPVNFTQCATHGSFPAHWQETLYNMFTFFCLFLLPLLIMIFCYT 188
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
54-313 4.59e-10

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 60.19  E-value: 4.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15199   22 LWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLFMLSLSRGVSIAFLTAVALDRYFR 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPR--LSATATKVVIFVIWVLALLLAFPqgyySTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15199  102 VVHPRGKKnsLSLQAAPYISFLVWLLLVGLTIP----TLLASQPKNFTECNSFSPKDDEDFSDTWQEAVFFLQFLLPFGL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IgyAYTVVGITLWASEIPGDSSDRYHEQVSakrkvVKMMIVVVCTFAICWLPFHIFFLLPYI--NPDL-YLKKFIQQVYL 288
Cdd:cd15199  178 I--VFCTVRIIRRLKKRLRDVGKQPKLQRA-----MALVTSVVVVFGFCFLPCFLARVLMLIfqNKEScNALNIAVHTYD 250
                        250       260
                 ....*....|....*....|....*
gi 568941324 289 ASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15199  251 VTMCLTYLNSVLDPIVYCFSSPTFR 275
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
70-267 5.50e-10

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 59.71  E-value: 5.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  70 FLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL--QPRLSATAT 147
Cdd:cd15376   39 FSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFTCNLYGSIFFITCISLNRYLGIVHPFftRSHVRPKHA 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 148 KVVIFVIWVLALLLAFPQGYYSTTETMP-SRVVCMIEWPEHPNRTYeKAYHICVTVLIYFLPLLVIGYAYTVVGITLWAS 226
Cdd:cd15376  119 KLVSLAVWLLVAALSAPVLSFSHLEVERhNKTECLGTAVDSRLPTY-LPYSLFLAVVGCGLPFLLTLASYLAIVWAVLRS 197
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 568941324 227 EipgdssdryHEQVSAKRKVVKMMIVVVCTFAICWLPFHIF 267
Cdd:cd15376  198 P---------GITTLEKRKVAALVAVVVALYAVSFVPYHIL 229
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
60-305 6.41e-10

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 59.83  E-value: 6.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  60 HKRMRtvtnYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ 139
Cdd:cd15387   32 HSRMY----FFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCRLVKYLQVVGMFASTYMLLLMSIDRCLAICQPLR 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 140 pRLSATATKVVIFVIWVLALLLAFPQGY-YSTTETMPSRVVCmieWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTV 218
Cdd:cd15387  108 -SLHRRSDRVYVLFSWLLSLVFSIPQVHiFSLREVGNGVYDC---WADFIQPWGPKAYITWITLSVYIIPVLILSVCYGL 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 219 VGITLW---------ASEIPGDSSDRYHEQVS----------AKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYL 279
Cdd:cd15387  184 ISFKIWqnvklktrrETKTPLSSAASGGAALArvssvkliskAKIRTVKMTFVIVLAYIVCWTPFFFVQMWSVWDPNAPK 263
                        250       260
                 ....*....|....*....|....*.
gi 568941324 280 KKFiqqVYLASMWLAMSSTMYNPIIY 305
Cdd:cd15387  264 EAS---PFIIAMLLASLNSCCNPWIY 286
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
54-313 7.39e-10

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 59.38  E-value: 7.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEacMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15184   22 VLILINCKKLKSMTDIYLLNLAISD--LLFLLTLPFWAHYAANEWVFGNAMCKLLTGLYHIGFFSGIFFIILLTIDRYLA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVI--FVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd15184  100 IVHAVFALKARTVTFGVVtsVVTWVVAVFASLPGIIFTKSQKEGSHYTCSPHFPPSQYQFWKNFQTLKMNILGLVLPLLV 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVVGITLWASEipgdSSDRYHEQVSakrkvvkMMIVVVCTFAICWLPFHIFFLLPYINP-----DLYLKKFIQQV 286
Cdd:cd15184  180 MIICYSGILKTLLRCR----NEKKRHKAVR-------LIFTIMIVYFLFWAPYNIVLLLNTFQEffglnNCSSSNRLDQA 248
                        250       260
                 ....*....|....*....|....*..
gi 568941324 287 YLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15184  249 MQVTETLGMTHCCINPVIYAFVGEKFR 275
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
60-219 8.93e-10

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 59.43  E-value: 8.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  60 HKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ 139
Cdd:cd15386   28 MRRKMSRMHLFVLHLALTDLVVALFQVLPQLIWEITYRFQGPDLLCRAVKYLQVLSMFASTYMLIMMTVDRYIAVCHPLR 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 140 P-RLSATATKVVIFVIWVLALLLAFPQGY-YSTTETMPSRVV--CmieWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYA 215
Cdd:cd15386  108 TlQQPSRQAYLMIGATWLLSCILSLPQVFiFSLREVDQGSGVldC---WADFGFPWGAKAYITWTTLSIFVLPVAILIVC 184

                 ....
gi 568941324 216 YTVV 219
Cdd:cd15386  185 YSLI 188
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
60-309 9.18e-10

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 59.44  E-value: 9.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  60 HKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYA-VHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL 138
Cdd:cd15198   28 GRRRKSRMNFLLLQLALADLLVIGGTALSQIIWElLGDRWMAGDVACRLLKLLQASARGASANLVVLLALDRHQAIRAPL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 139 QPRLSATAtkvVIFVIWVLALLLAFPQGYYSTTETMPSRVVcmiEWPEHP---------NRTYEKAYHICVTVLIYFLPL 209
Cdd:cd15198  108 GQPLRAWK---LAALGWLLALLLALPQAYVFRVDFPDDPAS---AWPGHTlcrgifaplPRWHLQVYATYEAVVGFVAPV 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVGITLW--ASEIPGDSSDRYHEQVS------------AKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINP 275
Cdd:cd15198  182 VILGVCYGRLLLKWWerANQAPGAKKPWKKPSKShlratapsalprAKVKTLKMTLVIALLFVGCSLPYFIAELAAAFGS 261
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568941324 276 DLYLKKfiqQVYLASMWLAMSSTMYNPIIYCCLN 309
Cdd:cd15198  262 GDWEPE---KVAAALGVMAVANSATNPFVFLFFN 292
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
60-316 1.01e-09

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 58.98  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  60 HKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ 139
Cdd:cd15086   28 YKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIVSLISLAVLSYERYCTLLRPTE 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 140 PRLSA-TATKVVIFVIWVLALLLAFPQGY-YSTTETMPSRVVCMIEWpeHPNRTYEKAYHICVTVLIYFLPLLVIGYAYt 217
Cdd:cd15086  108 ADVSDyRKAWLGVGGSWLYSLLWTLPPLLgWSSYGPEGPGTTCSVQW--TSRSANSISYIICLFIFCLLLPFLVMVYCY- 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 218 vvGITLWASEIPGD---SSDRYHEQvsakRKVVKMMIVVVCtFAICWLPFHIFFLLPYINPdlyLKKFIQQVYLASMWLA 294
Cdd:cd15086  185 --GRLLYAIKQVGKinkSTARKREQ----HVLLMVVTMVIC-YLLCWLPYGVMALLATFGK---PGLVTPVASIVPSILA 254
                        250       260
                 ....*....|....*....|..
gi 568941324 295 MSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15086  255 KSSTVVNPIIYVFMNKQFYRCF 276
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
98-316 1.06e-09

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 58.81  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  98 WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSA--TATKVVIFVIWVLALLLAFPQGYYSTTETMP 175
Cdd:cd15328   67 WQLGRSLCQVWISFDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTrrRISNVMIALTWALSAVISLAPLLFGWGETYS 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 176 SRVvcmiewpEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYtvvgitlWaseipgdssdRYHEQVSAKRKVVKMMIVVVC 255
Cdd:cd15328  147 EDS-------EECQVSQEPSYTVFSTFGAFYLPLCVVLFVY-------W----------KIYKAAQKEKRAALMVGILIG 202
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568941324 256 TFAICWLPfhiFFLLPYINP--DLYLKKFIQQVYLasmWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15328  203 VFVLCWIP---FFLTELISPlcSCDIPPIWKSIFL---WLGYSNSFFNPLIYTAFNKNYNNAF 259
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
56-331 1.27e-09

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 59.02  E-value: 1.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNvWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:PHA03087  63 YVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQ-WSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIV 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HPLQ--PRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWpeHPNRTYEKAY-HICVTVLIYFLPLLVI 212
Cdd:PHA03087 142 HPVKsnKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFY--NNKTMNWKLFiNFEINIIGMLIPLTIL 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 213 GYAYTVVGITLWASEIPgdssdryheqvSAKRKVVKMMIVVVCTFAICWLPFH--IFFLLPYINPDLYL---KKFIQQVY 287
Cdd:PHA03087 220 LYCYSKILITLKGINKS-----------KKNKKAIKLVLIIVILFVIFWLPFNvsVFVYSLHILHFKSGckaVKYIQYAL 288
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568941324 288 LASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDY 331
Cdd:PHA03087 289 HVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLKLMFTSSGKSI 332
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
68-313 1.33e-09

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 58.57  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  68 NYFLVNLAFAEACMAAFNTVVNFTYAvHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHP-----LQPRL 142
Cdd:cd15378   36 NIYLFNLSVSDLAFLCTLPMLVYSYS-NGQWLFGDFLCKSNRYLLHANLYSSILFLTFISIDRYLLIKYPfrehiLQKKR 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 143 SATAtkvVIFVIWVLALLLAFPQGYYSTTETMPSRVVCmIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYtvVGIT 222
Cdd:cd15378  115 SAVA---ISLAIWVLVTLELLPILTFIGPNLKDNVTKC-KDYASSGDATNSLIYSLFLTVTGFLIPLCVMCFFY--YKIA 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 223 LWASeipgdSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIF------FLLPYINPDLYLKKFIQQVYLASMWLAMS 296
Cdd:cd15378  189 LFLK-----NRNRQLANATSFEKPLTLVILAVVIFSVLFTPYHVMrnvriaSRLDSIGVSECTLIIIKSLYIVTRPIAFL 263
                        250
                 ....*....|....*..
gi 568941324 297 STMYNPIIYCCLNDRFR 313
Cdd:cd15378  264 NSVINPVFYFLMGDHFR 280
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
38-313 1.35e-09

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 58.67  E-value: 1.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  38 AYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEaCMAAFNTVVNFTYAVHNV-WYYGLFYCKFHNFFPIAAL 116
Cdd:cd15921    6 AYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISD-LLLVCTLPLRLTYYVLNShWPFGDIACRIILYVLYVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 117 FASIYSMTAVAFDRYMAIIHPLQpRLSATATKVVIFV---IWVLALLLAFPQGYYSTTETMPSRVVCMieWPEHPNRTYE 193
Cdd:cd15921   85 YSSIYFLTALSVFRYLALVWPYL-YLRVQTHSVAGIIcglIWILMGLASSPLLFAKSKQHDEGSTRCL--ELAHDAVDKL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 194 KAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHI-----FF 268
Cdd:cd15921  162 LLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPA------LGRTRPSRRKACALIIISLGIFLVCFLPYHIvrtihLI 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 568941324 269 LLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15921  236 TERQIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFR 280
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
33-164 1.55e-09

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 59.01  E-value: 1.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNV-WYYGLFYCKFHNFF 111
Cdd:cd15005    1 ALKLTTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSgWIYGALSCKVIAFL 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568941324 112 PIAALFASIYSMTAVAFDRYMAIIHP--LQPRLSATATKVVIFVIWVLALLLAFP 164
Cdd:cd15005   81 AVLFCFHSAFTLFCIAVTRYMAIAHHrfYAKRMTFWTCLAVICMAWTLSVAMAFP 135
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
54-305 1.61e-09

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 58.41  E-value: 1.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15314   22 IISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLCTASILNLCFISIDRYYA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPR--LSATATKVVIFVIWVLALLLAFpqgyysttetmpsrvvCMIEWPEHPNRTYEKAYH-------------- 197
Cdd:cd15314  102 VCQPLLYRskITVRVVLVMILISWSVSALVGF----------------GIIFLELNIKGIYYNHVAceggclvffskvss 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 198 ICVTVLIYFLPLLVIGYAYTvvGITLWASE----IPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLL-PY 272
Cdd:cd15314  166 VVGSVFSFYIPAVIMLCIYL--KIFLVAQRqarsIQSARTKSGASSSKMERKATKTLAIVMGVFLLCWTPFFLCNIIdPF 243
                        250       260       270
                 ....*....|....*....|....*....|...
gi 568941324 273 INPDLYLkkfiqQVYLASMWLAMSSTMYNPIIY 305
Cdd:cd15314  244 INYSIPP-----VLIEVLNWLGYSNSTLNPFIY 271
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
61-313 2.15e-09

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 57.92  E-value: 2.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHplQP 140
Cdd:cd15078   29 KRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFGIVSIMTLTVLAYERYIRVVH--AK 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 141 RLSATATKVVIFVIWVLALLLA-FPQGYYSTTETMPSRVVCMIEW-PEHPNRTyekAYHICVTVLIYFLPLLVIGYAYtv 218
Cdd:cd15078  107 VVNFSWSWRAITYIWLYSLAWTgAPLLGWNRYTLEVHGLGCSFDWkSKDPNDT---SFVLLFFLGCLVVPLGIMAYCY-- 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 219 vGITLWASEIPGDSSDRYHEQV----SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINpdlYLKKFIQQVYLASMWLA 294
Cdd:cd15078  182 -GHILYEIRMLRSVEDLQTFQVikilKYEKKVAKMCLLMISTFLICWMPYAVVSLLVTSG---YSKLVTPTIAIIPSLFA 257
                        250
                 ....*....|....*....
gi 568941324 295 MSSTMYNPIIYCCLNDRFR 313
Cdd:cd15078  258 KSSTAYNPVIYIFMIRKFR 276
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
61-316 2.22e-09

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 57.71  E-value: 2.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQP 140
Cdd:cd15049   29 RQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPLTY 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 141 RLSATATKVVIFVI--WVLALLLAFPQ----GYYSTTETMPSRvVCMIEWPEHPNRTYekayhicVTVLIYF-LPLLVIG 213
Cdd:cd15049  109 RAKRTPKRAILMIAlaWVISFVLWAPAilgwQYFVGERTVPDG-QCYIQFLDDPAITF-------GTAIAAFyLPVLVMT 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 214 YAYTVVgitlwaseipgdssdrYHEQVSAKRKVVKMMIVVVcTFAICWLPFHIFFLL-----PYINPDLylkkfiqqvYL 288
Cdd:cd15049  181 ILYWRI----------------YRETARERKAARTLSAILL-AFIITWTPYNILVLVstfcaKCIPDTL---------WS 234
                        250       260
                 ....*....|....*....|....*....
gi 568941324 289 ASMWLA-MSSTMyNPIIYCCLNDRFRLGF 316
Cdd:cd15049  235 FGYWLCyINSTI-NPFCYALCNKTFRKTF 262
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
57-313 2.59e-09

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 57.28  E-value: 2.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15210   25 LLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLITLNRYILIAH 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 P-LQPRLSATATKVV-IFVIWV--LALLLAFPQGYYSTTETMPSRVVCMIEWPEHpNRTYEKayhicVTVLIYF-LPLLV 211
Cdd:cd15210  105 PsLYPRIYTRRGLALmIAGTWIfsFGSFLPLWLGIWGRFGLDPKVCSCSILRDKK-GRSPKT-----FLFVFGFvLPCLV 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTvvgitlwaseipgdssdryheQVSAKRKVVKMMIVVVCtFAICWLPfhiFFLLpyinpDLYLKKFIQQV-YLAS 290
Cdd:cd15210  179 IIICYA---------------------RREDRRLTRMMLVIFLC-FLVCYLP---ITLV-----NVFDDEVAPPVlHIIA 228
                        250       260
                 ....*....|....*....|...
gi 568941324 291 MWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15210  229 YVLIWLSSCINPIIYVAMNRQYR 251
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
61-313 2.84e-09

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 57.56  E-value: 2.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQP 140
Cdd:cd15318   29 KALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFISIDRHCAICDPLLY 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 141 RLSATATKVVIFVI--WVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIG-YAYT 217
Cdd:cd15318  109 PSKFTIRVACIFIAagWLVPTVYTSVFLYTKAVEEGLAELLTSVPCVGSCQLLYNKLWGWLNFPVFFIPCLIMIGlYVKI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 218 VVGITLWASEIPGDSSD----RYHEQVSAKrkvvkMMIVVVCTFAICWLPFHI----FFLLPYINPDLYLKKFIqqvyla 289
Cdd:cd15318  189 FIVAKRQARAIASLLSDtngaSKRERKAAK-----TLGIAVGVYLLCWLPFTIdtmvDSLLNFITPPLLFDIII------ 257
                        250       260
                 ....*....|....*....|....
gi 568941324 290 smWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15318  258 --WFAYFNSACNPLIYVFSYPWFR 279
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
54-267 2.94e-09

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 57.78  E-value: 2.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15967   22 LKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKGRKWIFGQVFCKITRFCFNLNLYGSIGFLTCISVYRYLA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQP--RLSATATKVVIFVIWVLALLLAFPQGYYSttETMPSRVVCMIEWPEHPNRTYeKAYHICVTVLIYFLPLLV 211
Cdd:cd15967  102 IVHPMRVmgRITTTHSVVISALVWLLVVIQSLPDLFFS--KTNSNGTKCFDTTFNDYLESY-LTYSLGWTVTGFVIPLLI 178
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568941324 212 I--GYAYTVVGITLWASEIPGdssdryheqvsAKRKVVKMMIVVVCTFAICWLPFHIF 267
Cdd:cd15967  179 IlgCYGHVVVVLCRNNNVDKG-----------LKQRCLKLVIILIVLFSVCYIPYHVF 225
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
73-316 3.31e-09

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 57.41  E-value: 3.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  73 NLAFAEACM--AAFNTVVNFTYAVHnvWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ---PRLSATAT 147
Cdd:cd15922   41 NLALSDAIItpAAPLLIAYFSLGSH--WPFGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVHYNWkslWKKKSFMK 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 148 KVVIFViWVLALLLAFPQGYYSTTETMPSRVVCM-IEWPEHPNRTYekAYHICVTVLIYFLPLLVIGYAYTVVGITLwAS 226
Cdd:cd15922  119 KLCLGV-WLLLFVQGLPFFFVLKTSVIDGKTKCLsIHQSELSLLYF--VWNFVLLILGFLLPFGVSLTCYALLGASI-AK 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 227 EIPGDSSDRyheqvSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLY-----LKKFIQQVYLASMWLAMSSTMYN 301
Cdd:cd15922  195 MNSNNARGR-----AMKAKSLQMIGISLVIFIICFVPLHVTRTVGVVVKLFYpesctLLHKVEVAYYISWVLTGVNCCLD 269
                        250
                 ....*....|....*
gi 568941324 302 PIIYCCLNDRFRLGF 316
Cdd:cd15922  270 PLLYCFASEKFRKSF 284
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
36-216 4.25e-09

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 57.12  E-value: 4.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  36 AAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAA 115
Cdd:cd15054    4 AAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMC 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 116 LFASIYSMTAVAFDRYMAIIHPLQPRLSATATKV--VIFVIWVLALLLAFP--------QGYYSTTETMPSRVVcmiewP 185
Cdd:cd15054   84 CSASILNLCVISLDRYLLIISPLRYKLRMTPPRAlaLILAAWTLAALASFLpielgwheLGHERTLPNLTSGTV-----E 158
                        170       180       190
                 ....*....|....*....|....*....|.
gi 568941324 186 EHPNRTYEKAYHICVTVLIYFLPLLVIGYAY 216
Cdd:cd15054  159 GQCRLLVSLPYALVASCLTFFLPSGAICFTY 189
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
54-313 5.81e-09

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 56.71  E-value: 5.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd14988   22 IWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYFYFANMYSSIFFLTCLSVDRYLT 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQP--RLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRvVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLV 211
Cdd:cd14988  102 LTSSSPFwqQHQHRIRRALCAGIWVLSAIIPLPEVVHMQLLDGVEP-MCLFLAPFETYDEWALAVSLLTLIIGFLIPFSI 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IgyaytVVGITLWASEIpgdssdRYHEQVSAKRKVVKMMIVVVcTFAICWLPFHIFFLL-----PYINPDLYLKKFIQQV 286
Cdd:cd14988  181 I-----AVFNVLTARYI------RTAGRPESRRHCLLIYAYIL-VFVVCWLPYHVTLLLltlhgSHISLHCNLVHFLYFF 248
                        250       260
                 ....*....|....*....|....*..
gi 568941324 287 YLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd14988  249 YDVIDCFSLLHCVANPILYNFLSKSFR 275
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
52-306 6.80e-09

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 56.28  E-value: 6.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  52 VVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRY 131
Cdd:cd14964   18 LVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANLASIWTTLVLTYHRY 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 132 MAIIHPLQPRLSATA--TKVVIFVIWVLALLLAFPqgYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTvliYFLPL 209
Cdd:cd14964   98 FALCGPLKYTRLSSPgkTRVIILGCWGVSLLLSIP--PLVGKGAIPRYNTLTGSCYLICTTIYLTWGFLLVS---FLLPL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVvcTFAICWLPFHIFFLLPYINPDLYLKKfiqQVYLA 289
Cdd:cd14964  173 VAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVI--TFLLCWLPFSIVFILHALVAAGQGLN---LLSIL 247
                        250
                 ....*....|....*..
gi 568941324 290 SMWLAMSSTMYNPIIYC 306
Cdd:cd14964  248 ANLLAVLASTLNPFIYC 264
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
56-315 7.23e-09

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 56.38  E-value: 7.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:cd15008   23 VIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVLLSICVDRFYTIV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTetmpsrvvcmiEWPEHPN----RTYEKAYHICVTVLIYFL-PLL 210
Cdd:cd15008  103 YPLSFKVSREKAKKMIAASWLFDAAFVSPALFFYGS-----------NWGPHCNfflpDSWDGAAYAIIHLLVGFLvPSI 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLWASEIPGDSSDRYHEQV-SAKRKVVKMMIVVVCTFAICWLPFHIFFLLpyiNPDLYLKKFIQQVYLA 289
Cdd:cd15008  172 LIILFYQKVIKYIWRIGTDGRTVRRTMNIVpRTKVKTIKMFLMLNSMFLLSWLPFYVVQLW---HPRESDYRQSSLVFLA 248
                        250       260
                 ....*....|....*....|....*.
gi 568941324 290 SMWLAMSSTMYNPIIYCCLNDRFRLG 315
Cdd:cd15008  249 VTWISFSSSASKPTLYSVYNANFRRG 274
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
98-313 8.95e-09

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 56.30  E-value: 8.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  98 WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRL--SATATKVVIFVIWVLALLLAFPQGYYSTTETMP 175
Cdd:cd15924   65 WQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRYLKIVRPFKTSFpkSVSFAKILSVVVWALMFLLSLPNMILTNQQPRE 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 176 SRVV-CMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYaytvvgiTLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVV 254
Cdd:cd15924  145 KNVKkCSFLKSELGLKWHEIVNYICQVIFWIVFLLMIVCY-------TAITKKVYRSYRRVFRSSSSRRKKSNVKIFIIV 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568941324 255 CTFAICWLPFHiFFLLPYI------NPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15924  218 AVFFVCFVPYH-FARIPYTlsqtrdVFDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFR 281
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
34-313 1.03e-08

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 55.89  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  34 LWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEaCMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPI 113
Cdd:cd15152    2 IYAVTYTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIAD-LLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 114 AALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVI-WVLALL--LAFPQGYYSTTETmpsRVVCMIEWPEHPNR 190
Cdd:cd15152   81 VNMYASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYISIAgWLVVCVgcLPFPLLRQSQDTN---PTCCFADLPLRNVG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 191 TYEKAYHICVTVLIYF-LPLLVIGYAYtvvgitlWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFL 269
Cdd:cd15152  158 LTTSVIMLTIAELTGFvTPLLIVLYCS-------WKTVMSLREKTPVLQDLGEKKKALKMILTCAVVFLICFAPYHISFP 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 568941324 270 LPYI-----NPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15152  231 LDFLvksnkIKSCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFK 279
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
57-317 1.04e-08

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 55.73  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15334   25 IIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITD 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPRLSATATK--VVIFVIWVLALLLAFPQGYYSTtETMPSRVVCMIewpehpnrtyeKAYHICVTVL----IYFLPLL 210
Cdd:cd15334  105 AVEYARKRTPKHagIMIAVVWIISIFISMPPLFWRH-QTTSREDECII-----------KHDHIVFTIYstfgAFYIPLA 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTvvgitlwaseipgdssdRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQvYLAs 290
Cdd:cd15334  173 LILILYY-----------------KIYRAATRERKAATTLGLILGAFVICWLPFFVKEVIVNTCDSCYISEEMSN-FLT- 233
                        250       260
                 ....*....|....*....|....*..
gi 568941324 291 mWLAMSSTMYNPIIYCCLNDRFRLGFK 317
Cdd:cd15334  234 -WLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
61-316 1.07e-08

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 55.81  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQP 140
Cdd:cd15309   29 KALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLY 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 141 RLSATATK---VVIFVIWVLALLLAFPQ--GYYSTTETmpsrvVCMIEWPehpnrtyekAYHICVTVLIYFLPLLVIGYA 215
Cdd:cd15309  109 NTRYSSKRrvtVMISVVWVLSFAISCPLlfGLNNTDQN-----ECIIANP---------AFVVYSSIVSFYVPFIVTLLV 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 216 YTVVGITLwaseipgdssdryheqvSAKRKVVKMMIVVVCTFAICWLPFHIFFLLpyinpDLYLK-KFIQQVYLASMWLA 294
Cdd:cd15309  175 YVQIYIVL-----------------QKEKKATQMLAIVLGVFIICWLPFFITHIL-----NMHCDcNIPPALYSAFTWLG 232
                        250       260
                 ....*....|....*....|..
gi 568941324 295 MSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15309  233 YVNSAVNPIIYTTFNIEFRKAF 254
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
61-315 1.40e-08

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 55.44  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAE------ACMAAFNTVVNFtyavhnvWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAI 134
Cdd:cd15072   29 RELRTPSNLLVLSLAVADmgislnALVAASSSLLRR-------WPYGSEGCQAHGFQGFFTALASICSSAAIAWDRYHHY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 135 IHPLQpRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHpNRTYEkAYHICVTVLIYFLPLLVIGY 214
Cdd:cd15072  102 CTRSK-LQWSTAISLVLFVWLFSAFWAAMPLLGWGEYDYEPLGTCCTLDYSKG-DRNYV-SYLFTMAFFNFILPLFILLT 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 215 AYtvvgitlwaSEIPGDSSDRYHEQVSAkrkvvkmmIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVylaSMWLA 294
Cdd:cd15072  179 SY---------SSIEQKLKKEGHLRFNT--------GLPLLTLLICWGPYAILALYAAITDVTSISPKLRMV---PALLA 238
                        250       260
                 ....*....|....*....|.
gi 568941324 295 MSSTMYNPIIYCCLNDRFRLG 315
Cdd:cd15072  239 KTSPTINAILYALGNENYRGG 259
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
33-313 1.63e-08

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 55.19  E-value: 1.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEaCMAAFNTVVNFTYAVH-NVWYYGLFYCKFHNFF 111
Cdd:cd15370    1 VFLPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALAD-LLFVIWFPLKIAYHINgNNWIYGEALCKVLIGF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 112 PIAALFASIYSMTAVAFDRYMAIIHPL-QPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSR--VVCMIEWPEHP 188
Cdd:cd15370   80 FYGNMYCSILFMTCLSVQRYWVIVNPMsHSRKKANIAIGISLAIWLLILLVTIPLYLVKQTVFIPALdiTTCHDVLPEQL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 189 NRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEipgdsSDRYHEQvsAKRKVVKMMIVVVCTFAICWLPFHIFF 268
Cdd:cd15370  160 LVGDMFNYFLSLAIGVFLFPAFLTAVAYVLMIRALKSSI-----NDESIEK--KRKRAIKLIVTVLVMYLICFTPSNLLL 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 568941324 269 LLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15370  233 VVHYFLLKNQGQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
98-316 1.72e-08

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 55.57  E-value: 1.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  98 WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPR-LSATATKVVIFVIWVLALLLAFPQGYYSTTETmPS 176
Cdd:cd15135   71 TPSGNIACKIYNFLFEACSYATILNVATLSFERYIAICHPFKYKaLSGSRVRLLICFVWLTSALVALPLLFAMGTED-PL 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 177 RVVCMIEWPEHPNRTYEKAYHICVTV---------------LIYFLPLLVIGY------------AYTVVGITLWASEIP 229
Cdd:cd15135  150 EAFPSYRGTRHHCQDQKSNLTICTSLsskwtvfqasifsafVLYLLVLASVAFmcrrmmralmgsKKGAVAVKGPGGSVQ 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 230 GDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINP-----DLYLKKFIQQVYLASMWLAMSSTMyNPII 304
Cdd:cd15135  230 LLRKHESAEGKTARKQTILFLGLIVGTLAVCWMPNQIRRIMAAAKPkddwtRSYFRAYIILLPIADTFFYLSSVL-NPLL 308
                        250
                 ....*....|..
gi 568941324 305 YCCLNDRFRLGF 316
Cdd:cd15135  309 YNLSSQQFRSVF 320
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
54-305 1.95e-08

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 55.17  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15388   22 LLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVGMFASSYMIVAMTFDRHQA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATAT-KVVIFVIWVLALLLAFPQGY-YSTTETMPSRVVCMIEWPEHPNRtyeKAYHICVTVLIYFLPLLV 211
Cdd:cd15388  102 ICRPMVTFQKGRARwNGPVCVAWAISLILSLPQVFiFSKVEVAPGVYECWACFIEPWGL---KAYVTWITLVVFVLPTLI 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYTVV------GITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVV---------VCTFAICWLPFHIFFLLPYINPD 276
Cdd:cd15388  179 ITVCQVLIfkeihiNIYLKSQIIVAVVKKKQLLSSRASSVAEVSKAMIktvkmtlviVLVYVLCWAPFFLVQLWSVWDPK 258
                        250       260
                 ....*....|....*....|....*....
gi 568941324 277 LYLKKfiqQVYLASMWLAMSSTMYNPIIY 305
Cdd:cd15388  259 APTEG---ATFTILMLLASLNSCTNPWIY 284
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
54-316 2.27e-08

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 54.82  E-value: 2.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMR---TVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15338   22 IYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLITALDTNSQITSTYILTVMTLDR 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPL------QPRLSAtatkVVIFVIWVLALLLAFPQGYYSTTETMPSRVV-CMIEWPEHPNRTYekAYHICVTVL 203
Cdd:cd15338  102 YLATVHPIrstkirTPRVAV----AVICLVWILSLLSITPVWMYAGLMPLPDGSVgCALLLPNPETDTY--WFTLYQFFL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 204 IYFLPLLVIGYAYTVVGITLWASEIPgdsSDRYHEQVSAKRKVVKMMIVVVcTFAICWLPFHIFFL--LPYINPDLYLkk 281
Cdd:cd15338  176 AFALPLVVICVVYFKILQNMASTVAP---LPQRSLRVRTKKVTRMAVAICL-AFFICWAPFYILQLahLSIDRPSLAF-- 249
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568941324 282 fiQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15338  250 --LYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
100-314 2.32e-08

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 54.76  E-value: 2.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 100 YGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKV--VIFVIWVLALLLAFPQ--GYYSTTETMP 175
Cdd:cd15220   67 FGEAECRVYIFLSVCLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVaaVLVGVWVKALLLGLLPvlGWPSYGGPAP 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 176 SRVV-CMIEWPEHPNRtyeKAYHICVTVLIYFLPLLVIGYAYTVVGITLwaseiPGDSSdryheqvsakrkvVKMMIVVV 254
Cdd:cd15220  147 IAARhCSLHWSHSGHR---GVFVVLFALVCFLLPLLLILVVYCGVFKVF-----GGGKA-------------ALTLAAIV 205
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568941324 255 CTFAICWLPFHIFfllpyinpDLYLKKFIQQVYLASM-----WLAMSSTMYNPIIYCCLNDRFRL 314
Cdd:cd15220  206 GQFLCCWLPYFAF--------HLYSALAASPVSGGEAeevvtWLAYSCFAVNPFFYGLLNRQIRE 262
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
54-322 2.48e-08

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 54.91  E-value: 2.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILA---HKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHN-VWYYGLFYCKFHNFFPIAALFASIYSMTAVAFD 129
Cdd:cd15305   19 ILVIMAvslEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLFSTASIMHLCAISLD 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 130 RYMAIIHPLQPRLSATATKVV--IFVIWVLALLLAFPQGY--YSTTETMPSRVVCMIEwpehpnrtyEKAYHICVTVLIY 205
Cdd:cd15305   99 RYVAIRNPIEHSRFNSRTKAMmkIAAVWTISIGISMPIPVigLQDDEKVFVNGTCVLN---------DENFVLIGSFVAF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 206 FLPLLVIGYAYTVVGITLwaseipgdssdRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQ 285
Cdd:cd15305  170 FIPLIIMVITYCLTIQVL-----------QRQQAINNERRASKVLGIVFFLFLIMWCPFFITNILSVLCKEACDQKLMEE 238
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568941324 286 VYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRC 322
Cdd:cd15305  239 LLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIRC 275
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
54-322 2.48e-08

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 54.84  E-value: 2.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILA---HKRMRTVTNYFLVNLAFAEACMAAF-NTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFD 129
Cdd:cd15306   19 ILVILAvslEKKLQYATNYFLMSLAVADLLVGLFvMPIALLTILFEAMWPLPLVLCPIWLFLDVLFSTASIMHLCAISLD 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 130 RYMAIIHPLQPRL--SATATKVVIFVIWVLALLLAFP---QGyYSTTETMPSRVVCMIEwpehPNRTYEkaYHICVTVLI 204
Cdd:cd15306   99 RYIAIKKPIQASQynSRATAFIKITVVWLISIGIAIPvpiKG-IETDVDNPNNITCVLT----KERFGD--FILFGSLAA 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 205 YFLPLLVIGYAYTVVGITLWASEIPgdssdryHEQVSAKrkvvkMMIVVVCTFAICWLPFHIFFLLPYINpDLYLKKFIQ 284
Cdd:cd15306  172 FFTPLAIMIVTYFLTIHALRKQTIT-------NEQRASK-----VLGIVFFLFLLMWCPFFITNITSVLC-DSCNQTTLQ 238
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568941324 285 QVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRC 322
Cdd:cd15306  239 MLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 276
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
57-313 2.61e-08

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 54.84  E-value: 2.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAfnTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15186   25 LTNSGKSKSITDIYLLNLALSDLLFVA--TLPFWTHYLINEWGLHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVL 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPRLSATATKVVIFV--IWVLALLLAFPQGYYSTTETMPsrvvCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGY 214
Cdd:cd15186  103 AANSMNNRTVQHGVTISlgVWAAAILVAVPQFMFTKMKENE----CLGDYPEVLQEIWPVLRNVELNFLGFLLPLLIMSY 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 215 AYTVVGITLWaseipgdsSDRYHEQVSAKRKVVKMMIvvvcTFAICWLPFHIFFLLPYIN-----PDLYLKKFIQQVYLA 289
Cdd:cd15186  179 CYFRIIQTLF--------SCKNHKKARAIKLILLVVI----VFFLFWTPYNVMIFLETLKlydffPSCDMKKDLRLALSV 246
                        250       260
                 ....*....|....*....|....
gi 568941324 290 SMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15186  247 TETIAFSHCCLNPLIYAFAGEKFR 270
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
54-163 4.62e-08

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 53.76  E-value: 4.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMrTVTNYFLVNLAFAEACMA---AFNTVVN-------FTYAVhnVWYYGLfYCKFHNFFPIAALFASIYSM 123
Cdd:cd15136   23 LVLLTSRTKL-TVPRFLMCNLAFADFCMGiylGLLAIVDaktlgeyYNYAI--DWQTGA-GCKTAGFLAVFSSELSVFTL 98
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 568941324 124 TAVAFDRYMAIIHPLQ--PRLSATATKVVIFVIWVLALLLAF 163
Cdd:cd15136   99 TVITLERWYAITHAMHlnKRLSLRQAAIIMLGGWIFALIMAL 140
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
54-273 5.60e-08

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 53.61  E-value: 5.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHnvWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15923   22 LWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSYRRE--SAGLQKLCNFVLSLYYINMYVSIFTITAISVDRYVA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPR--LSATATKVVIFVIWVLALLLAFPqgyYSTTETMPSRVVCMiewpeHPNRTYEKAYHICVTVLIYF-LPLL 210
Cdd:cd15923  100 IRYPLRARelRSPRKAAVVCAVIWVLVVTISIP---YFLLDSSNEKTMCF-----QRTKQTESLKVFLLLEIFGFlLPLI 171
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568941324 211 VIGYAYTVVGITLwaseipgDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYI 273
Cdd:cd15923  172 IMTFCSARVIHTL-------QKRLDDVGSRSETKQCIRVIMANLIVFIVCFLPVHVGFFVKFI 227
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
57-316 6.22e-08

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 53.34  E-value: 6.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15324   25 VFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTK 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQPRLSATA--TKVVIFVIWVLALLLAFPQGYYSTTETMPsrvvCMIewpehpnrTYEKAYHICVTVLIYFLPLLVIGY 214
Cdd:cd15324  105 AVSYNLKRTPkrIKRMIAVVWVISAVISFPPLLMTKHDEWE----CLL--------NDETWYILSSCTVSFFAPGLIMIL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 215 AYTVVgitlwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYIN------PDLYLKKFiqqvyl 288
Cdd:cd15324  173 VYCKI----------------YRVAKMREKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVCrkrcgiPDALFNLF------ 230
                        250       260
                 ....*....|....*....|....*...
gi 568941324 289 asMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15324  231 --FWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
95-306 6.59e-08

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 53.63  E-value: 6.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  95 HNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ---PRLSATATkVVIFVIWVL-----ALLLAFPQG 166
Cdd:cd15365   63 GDNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKfmhLRTIRTAL-SVSVAIWLLeicfnAVILTWEDS 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 167 YYSTTetmpSRVVCMIEWPEHPNRTYEKAYHICVTvliYFLPLLVIGYAYTVVGITLWASEIPGDSSdryheqvsaKRKV 246
Cdd:cd15365  142 FHESS----SHTLCYDKFPLEDWQARLNLFRICLG---YLLPLLIILFCYWKIYQAVRSNQATEDQE---------KKKI 205
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568941324 247 VKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLASMWLAMSS--TMYNPIIYC 306
Cdd:cd15365  206 FKLLLLITVTFVICFTPYHVVLLIRSIVEPCDCRNAKWLYTLYKITVALTSlnCIADPFLYC 267
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
51-313 8.27e-08

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 53.36  E-value: 8.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  51 VVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVnftyAVHNVWYYGLF-----------YCKFHNFFPIAALFAS 119
Cdd:cd15137   19 LFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVYLLII----ASVDLYYRGVYikhdeewrsswLCTFAGFLATLSSEVS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 120 IYSMTAVAFDRYMAIIHPLQP-RLSATATKVVIFVIWVLALLLAF-P-------QGYYSttetmpSRVVCMiewPEHPNR 190
Cdd:cd15137   95 VLILTLITLDRFICIVFPFSGrRLGLRRAIIVLACIWLIGLLLAVlPllpwdyfGNFYG------RSGVCL---PLHITD 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 191 TYEKA--YHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMivvvcTFAICWLPFHIFF 268
Cdd:cd15137  166 ERPAGweYSVFVFLGLNFLAFVFILLSYIAMFISIRRTRKAAASRKSKRDMAVAKRFFLIVL-----TDFLCWIPIIVIG 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 568941324 269 LLPY----INPDLYlkkfiqqVYLASMWLAMSSTMyNPIIYCCLNDRFR 313
Cdd:cd15137  241 ILALsgvpIPGEVY-------AWVAVFVLPINSAL-NPILYTLSTPKFR 281
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
66-316 1.04e-07

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 53.08  E-value: 1.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  66 VTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFyCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL--QPRLS 143
Cdd:cd15320   36 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFryERKMT 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 144 ATATKVVIFVIWVLALLLAF-----------PQGYYSTTETMPSRVVcmiewpEHPNRTYEKAYHICVTVLIYFLPLLVI 212
Cdd:cd15320  115 PKVAFIMISVAWTLSVLISFipvqlnwhkakPTSFLDLNASLRDLTM------DNCDSSLNRTYAISSSLISFYIPVAIM 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 213 GYAYTVVgITLWASEI------------------------PGDSSDRYHE-QVSAKRKVVKMMIVVVC--TFAICWLPFH 265
Cdd:cd15320  189 IVTYTRI-YRIAQKQIrrisaleraavhakncqnstgnrgSGDCQQPESSfKMSFKRETKVLKTLSVImgVFVCCWLPFF 267
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568941324 266 IF-FLLPYINPDLYLKKFIQQ-VYLASMWLAMSSTMYNPIIYcCLNDRFRLGF 316
Cdd:cd15320  268 ILnCMVPFCKPTSTEPFCISStTFDVFVWFGWANSSLNPIIY-AFNADFRKAF 319
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
64-316 1.19e-07

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 52.76  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  64 RTVTNYFLVNLAFAE---ACMAAFNTVVNFTYAVHNVwyyGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLqp 140
Cdd:cd15104   32 DTKSNCFLLNLAIADflvGLAIPGLATDELLSDGENT---QKVLCLLRMCFVITSCAASVLSLAAIAFDRYLALKQPL-- 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 141 RLSATATKVVIF----VIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNrtyekaYHICVTVLIYFLPLLVIGYAY 216
Cdd:cd15104  107 RYKQIMTGKSAGaliaGLWLYSGLIGFLPLISPQFQQTSYKGKCSFFAAFHPR------VLLVLSCMVFFPALLLFVFCY 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 217 TVVGIT-------LWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCtFAICWLPFHIFFLLPYINPDLYLKKFIqQVYLA 289
Cdd:cd15104  181 CDILKIarvhsraIYKVEHALARQIHPRRTLSDFKAARTVAVLIGC-FLLSWLPFQITGLVQALCDECKLYDVL-EDYLW 258
                        250       260
                 ....*....|....*....|....*..
gi 568941324 290 smWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15104  259 --LLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
87-313 1.46e-07

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 52.10  E-value: 1.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  87 VVNFTYAVHNVWYYG---LFYCKF-HNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPR--LSATATKVVIFVIWVLALL 160
Cdd:cd15163   48 LVGLSLPTRIVMYYSagnCLTCSFvHIFSYFVNMYCSILFLTCICVDRYLAIVQVEASRrwRNPNYAKGICVFIWLFAIV 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 161 LAFpqGYYSTTETMPSRVVCMIewpehpnrtyekayhICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV 240
Cdd:cd15163  128 VTF--SILTTAIKFASCCLSKL---------------FALTVFEFFLPLLIITFFTIRIMCALSRPGLMHQSRERRMRAV 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568941324 241 SakrkvvkMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIqQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15163  191 Q-------LLITVLIIFMICFTPFHVRQVAVAFNPDIPHHTSL-IVYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
38-316 2.15e-07

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 52.08  E-value: 2.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  38 AYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALF 117
Cdd:cd15368    6 VYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVLFYANMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 118 ASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVI--WVLALLLAFPQGYYSTTETMPSR--VVC--MIEWPEHPNRT 191
Cdd:cd15368   86 SSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIgmWLLVLTALSPLERTDLTYYVKELniTTCfdVLKWTMLPNIA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 192 YEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWaseipgDSSDRYHEQvsAKRKVVKMMIVVVCTFAICWLPFHiFFLLP 271
Cdd:cd15368  166 AWAAFLFTLFILLFLIPFIITVYCYVLIILKLV------QTSERYGRE--QKRRAIYLALIVLLVFITCFAPNN-FILLA 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 568941324 272 YINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15368  237 HMVSRLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
34-313 2.34e-07

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 51.72  E-value: 2.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  34 LWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAaFNTVVNFTYAVHNVWYYGLFYCKFHNFFPI 113
Cdd:cd15153    2 LYATTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHV-LSLPLRIHYYIQHTWPFGRFLCLLCFYLKY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 114 AALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVI-FVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTY 192
Cdd:cd15153   81 LNMYASICFLTCISIQRCFFLLHPFKARDWKRRYDVGIsAAVWIVVGLACLPFPLLRSKSLSNNNRSCFADLGMKKLNFG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 193 EKAYHICVTVLIYFL-PLLVIGYAytvvgitLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLL- 270
Cdd:cd15153  161 AAIAMMTVAELFGFViPLFIIAWC-------TWKTENSLRQRNKQQQSTSEKQKALRMVRMCAAVFFICFAPYHINFLFy 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 568941324 271 ----PYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15153  234 lmvsESIITNCEVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
56-316 2.46e-07

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 51.78  E-value: 2.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:cd15976   24 IIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVA 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HplQPRLSATA----TKVVIFVIWVLALLLAFPQGYYSTTETMPSR----VVCMIewpeHPNRT------YEKAYHICVT 201
Cdd:cd15976  104 S--WSRIKGIGvpkwTAVEIVLIWVVSIILAVPEAIGFDMITMDYKgellRICLL----HPIQKtafmqfYKTAKDWWLF 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 202 VLIYFLPLLVIGYAYTVVGITLWASEipGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYInpdLYLKK 281
Cdd:cd15976  178 SFYFCLPLACTAVFYTLMTCEMLRKK--NGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLT---IYDEK 252
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 568941324 282 FIQQVYLASMWLAMS---------STMYNPIIYCCLNDRFRLGF 316
Cdd:cd15976  253 DPNRCELLSFFLVLDyiginmaslNSCINPIALYLVSKRFKNCF 296
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
61-313 3.02e-07

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 51.45  E-value: 3.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL-Q 139
Cdd:cd15081   41 KKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSVCGITGLWSLTIISWERWVVVCKPFgN 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 140 PRLSATATKVVIFVIWVL-ALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTV 218
Cdd:cd15081  121 IKFDGKLAIVGIIFSWVWsAVWCAPPIFGWSRYWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMITCCIIPLAIIILCYLQ 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 219 VGITLWASEIPGDSSDRYHEqvsAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVylaSMWLAMSST 298
Cdd:cd15081  201 VWLAIRAVAQQQKESESTQK---AEKEVSRMVVVMIFAYCFCWGPYTFFACFAAANPGYAFHPLAAAL---PAYFAKSAT 274
                        250
                 ....*....|....*
gi 568941324 299 MYNPIIYCCLNDRFR 313
Cdd:cd15081  275 IYNPIIYVFMNRQFR 289
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
57-316 3.39e-07

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 51.17  E-value: 3.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15298   25 IKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQ--PRLSATATKVVIFVIWVLALLLAFPQ----GYYSTTETMPSRvVCMIEWPEHPNRTYEKAyhicvtVLIYFLPLL 210
Cdd:cd15298  105 PLTypARRTTKMAGLMIAAAWVLSFVLWAPAilfwQFVVGKRTVPDN-QCFIQFLSNPAVTFGTA------IAAFYLPVV 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYtvVGITLWASEipgdssdryheqvsaKRKVVKMMIVVVCTFAICWLPFHIFFLLpyinpDLYLKKFI-QQVYLA 289
Cdd:cd15298  178 IMTVLY--IHISLASAR---------------ERKVTRTIFAILLAFILTWTPYNVMVLV-----NTFCQSCIpDTVWSI 235
                        250       260
                 ....*....|....*....|....*..
gi 568941324 290 SMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15298  236 GYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
54-313 3.51e-07

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 51.41  E-value: 3.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACmaAFNTVVNFTYAVHNV-----WYYGLFYCKFHNFFPIAALFASIYSMTAVAF 128
Cdd:cd15006   21 LWSTCRTSVFKSVTNRFIKNLACSGIC--ASLVCVPFDIVLSASphccwWIYTLLFCKVIKFLHKVFCSVTVLSFAAIAL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 129 DRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWpehPNRTYEKAYHICVTVLIYFLP 208
Cdd:cd15006   99 DRYYSVLYPLERKISDAKSRDLVIYIWAHAVVASVPVFAVTNVTDIYAMSTCTESW---GYSLGHLVYVIIYNITTVILP 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIGYAYTVVGITLWASE----------IPGDS-SDRYHEQVSAKrkVVKMMIVVVCTFAICWLPFHIFFLLPYInpdL 277
Cdd:cd15006  176 VAVVFLFMILIRRALSASQkkkviiaalrTPQNTiSIPYVSQREAE--LHAMLLSMVLVFILCSVPYATLVIYRTI---L 250
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568941324 278 YLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15006  251 NISDISVFLLLTAIWLPKVSLLANPLLFLTVNKSVR 286
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
54-216 3.55e-07

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 51.34  E-value: 3.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMaafntVVNFTYAVHNV---WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15187   22 IWVLVACKKLRSMTDVYLLNLAASDLLF-----VFSLPFQAYYLldqWVFGNAMCKIVSGAYYIGFYSSMFFITLMSIDR 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIH---PLQPRLSATATkVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRtYEKAYHICVTVLIYFL 207
Cdd:cd15187   97 YLAIVHavyALKVRTASHGT-ILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYPGQGNS-WKVFTNFEVNILGLLI 174

                 ....*....
gi 568941324 208 PLLVIGYAY 216
Cdd:cd15187  175 PFSILIFCY 183
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
54-223 3.55e-07

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 51.39  E-value: 3.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEaCMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15156   22 IYIFMCTLKVRNETTTYMINLAISD-LLFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMYGSILFLTCISVDRFLA 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATA--TKVVIFVIWVLALLLAFPQGYYSTTETMPS--RVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPL 209
Cdd:cd15156  101 IVYPFRSKTLRTKrnAKIVCAAVWLTVLAGSLPASFFQSTNNQLNnnSETCFENFSSKTWKTYLSKIVIFIEIVGFFIPL 180
                        170
                 ....*....|....
gi 568941324 210 LVIGYAYTVVGITL 223
Cdd:cd15156  181 ILNVTCSTMVLKTL 194
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
57-316 3.96e-07

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 51.12  E-value: 3.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIH 136
Cdd:cd15297   25 IKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTK 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 137 PLQ--PRLSATATKVVIFVIWVLALLLAFPQ----GYYSTTETMPsRVVCMIEWPEHPNRTYEKAyhicvtVLIYFLPLL 210
Cdd:cd15297  105 PLTypVKRTTKMAGMMIAAAWVLSFILWAPAilfwQFIVGGRTVP-EGECYIQFFSNAAVTFGTA------IAAFYLPVI 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYtvvgitlWaseipgdssdRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLylkkFIQQVYLAS 290
Cdd:cd15297  178 IMTVLY-------W----------QISRASSREKKVTRTILAILLAFIITWTPYNVMVLINTFCASC----IPNTVWTIG 236
                        250       260
                 ....*....|....*....|....*.
gi 568941324 291 MWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15297  237 YWLCYINSTINPACYALCNATFKKTF 262
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
61-313 4.03e-07

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 50.98  E-value: 4.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQP 140
Cdd:cd15301   29 KQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTRPLTY 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 141 RLSATATKVVIFV--IWVLALLLaFPQGYYSTTETMPSRVV----CMIEWPE-HPNRTYEKAyhicvtVLIYFLPLLVIG 213
Cdd:cd15301  109 RARRTTKKAAVMIasAWIISLLL-WPPWIYSWPYIEGKRTVpagtCYIQFLEtNPYVTFGTA------LAAFYVPVTIMC 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 214 YAYTVVgitLWASEipgdssdryHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPdlYLKKFIQQVYLASMWL 293
Cdd:cd15301  182 ILYWRI---WRETK---------KRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFFP--CSDTIPTELWDFSYYL 247
                        250       260
                 ....*....|....*....|
gi 568941324 294 AMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15301  248 CYINSTINPLCYALCNAAFR 267
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
56-270 4.90e-07

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 50.98  E-value: 4.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVW-----YYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15128   24 IIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWpfgdqPFGQFLCKLVPFIQKASVGITVLNLCALSVDR 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIH--PLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSR----VVCMIEWPEHPNRTYEKAYHICVTVLI 204
Cdd:cd15128  104 YRAVASwsRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIGFDMVRFNYKgvtlRTCLLRPETSFMKFYIDVKDWWLFGFY 183
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568941324 205 YFLPLLVIGYAYTVVGITLWASEiPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLL 270
Cdd:cd15128  184 FCLPLVCTAIFYTLMTCEMLRKR-NGMLRIALNEHLKQRREVAKTVFCLVVIFALCWLPLHLSRIL 248
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
61-224 5.78e-07

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 50.98  E-value: 5.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQP 140
Cdd:cd15385   29 KKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLGMFASTYMLVMMTADRYIAICHPLKT 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 141 -RLSATATKVVIFVIWVLALLLAFPQ-GYYSTTETMPSRVV--CmieWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAY 216
Cdd:cd15385  109 lQQPTKRSYLMIGSAWALSFILSTPQyFIFSLSEIENGSGVydC---WANFIVPWGIKAYITWITISIFVVPVIILLTCY 185

                 ....*...
gi 568941324 217 TVVGITLW 224
Cdd:cd15385  186 GFICYNIW 193
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
56-306 8.83e-07

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 50.15  E-value: 8.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEacmaaFNTVVNFTYAVH-----NVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15200   24 IFCFHRRPWKSNTMYLLSLVVAD-----FFLIINLPFRIDyylrnEVWRFGATACQVNLFMLSMNRTASIVFLTAIALNR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQ--PRLSATATKVVIFVIWVLALLLafpQGYYSTTETMPSRVVCMiEWPEHPNRTYEKAYHICVTVLIYFLP 208
Cdd:cd15200   99 YLKVVHPHHqlSKASVGCAAKVAAGLWILILLL---NIHLLLLDHVQSNSTCL-SYDHGTDPSASDRWHRILFFLEFFLP 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 209 LLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAkrkvvkmmiVVVCTFAICWLPFHIFFLLPYI-----NPDLYlkKFI 283
Cdd:cd15200  175 LGIILFCIFSIILTLKQRKLAKQAGPQRAVKVLA---------VIVLVYTVCFLPSILFALASLVafkvsQCRSL--DLC 243
                        250       260
                 ....*....|....*....|...
gi 568941324 284 QQVYLASMWLAMSSTMYNPIIYC 306
Cdd:cd15200  244 TQLFHGSLAFTYLNSALDPVLYC 266
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
61-316 1.09e-06

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 49.79  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQP 140
Cdd:cd15296   29 SSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDYLLCTASVFNIVLISYDRFLSVTRAVSY 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 141 RLSATATKVVIF---VIWVLALLLAFP---QGYYSTTETMPSRVVCMIEWpehpnrTYEKAYHICVTVLIYFLPLLVIGY 214
Cdd:cd15296  109 RAQKGMTRQAVLkmvLVWVLAFLLYGPaiiSWEYIAGGSIIPEGECYAEF------FYNWYFLMTASTLEFFTPFISVTY 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 215 AYTVVGITLwaseipgdssDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHiffLLPYINPDLYLKKFIQQVYLASMWLA 294
Cdd:cd15296  183 FNLSIYLNI----------QKRRFRLSRDKKVAKSLAIIVCVFGLCWAPYT---LLMIIRAACHGHCVPDYWYETSFWLL 249
                        250       260
                 ....*....|....*....|..
gi 568941324 295 MSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15296  250 WVNSAINPVLYPLCHMSFRRAF 271
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
56-316 1.22e-06

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 49.86  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYY-----GLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15975   24 IIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFddssfGVFLCKLVPFLQKASVGITVLNLCALSVDR 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIH--PLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSR----VVCMIEWPEHPNRTYEKAYHICVTVLI 204
Cdd:cd15975  104 YRAVASwsRVQGIGIPLITAIEIFSIWVLSFILAIPEAIGFVMVPFEYNgeqyRTCMLNATTKFMNFYVDAKDWWLFGFY 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 205 YFLPLLVIGYAYTVVGITLWASEipgDSSDR--YHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLP---YINPD--- 276
Cdd:cd15975  184 FCVPLACTAIFYTLMTCEMLNRR---KGSLRiaLSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKktvYNENDprr 260
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568941324 277 LYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15975  261 CELLSFLLVMDYISINLATMNSCINPIALYFVSKKFKNCF 300
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
57-313 1.41e-06

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 49.45  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMAAFN-TVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:cd15308   25 VCTERALKTTTNYFIVSLAVADLLLALLVlPLYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCAISVDRFIAVS 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HPLQPRLSATATK--VVIFVIWVLALLLAFPQ--GYYSTTETMPSrvVCMIEwpehpnrtyEKAYHICVTVLIYFLPLLV 211
Cdd:cd15308  105 VPLNYNRRQGSVRqlLLISATWILSFAVASPVifGLNNVPNRDPA--VCKLE---------DNNYVVYSSVCSFFIPCPV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 212 IGYAYtvvgitlWASeipgdssdryHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKkfiQQVYLASM 291
Cdd:cd15308  174 MLVLY-------CAM----------FRGLGRERKAMRVLPVVVGAFLFCWTPFFVVHITRALCESCSIP---PQLISIVT 233
                        250       260
                 ....*....|....*....|..
gi 568941324 292 WLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15308  234 WLGYVNSALNPVIYTVFNAEFR 255
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
57-313 2.54e-06

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 48.62  E-value: 2.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFaeaCMAAFNTVVNFtYAVH----NVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd15120   24 VLGFKMRRTVNTLWFLHLIL---SNLIFTLILPF-MAVHvlmdNHWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPLQPRLSATATKV--VIFVIWVLALLLAFPQ-GYYSTTETMPSRVVCMI------EWPEHPNRTYEKAYH----IC 199
Cdd:cd15120  100 LTLHPVWSRQHRTNRWAsaIVLGVWISAILLSIPYlAFRETRLDEKGKTICQNnyalstNWESAEVQASRQWIHvamfVF 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 200 VTVLIYFLPLLVIGYAYTVVGITLWASEIpGDSSDRYHEQVSAkrkvvkmmivvVCTFAICWLPFHIFFllpyinpDLYL 279
Cdd:cd15120  180 RFLLGFLLPFLIITFCYVRMALKMKERGL-ARSSKPFKVMFTA-----------VVSFFVCWLPYHLHS-------GLVL 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568941324 280 KKFIQQVYL-ASMWLAMSSTMYN----PIIYCCLNDRFR 313
Cdd:cd15120  241 TRGRPPSLTdITLLLTVGTTCFNtcftPVLYLFVGENFK 279
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
33-266 2.56e-06

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 48.55  E-value: 2.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  33 VLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFP 112
Cdd:cd15161    1 ILFALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPL------QPRLSatatKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPE 186
Cdd:cd15161   81 YLNMYASLYFLACISVDRFLAIVHPVksmkirKPLYA----HVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQLYRE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 187 HPNRtyekayHICVTVLIYFL-PLLVIGYAYTVVGITLWASEipgdssdryHEQVSAKRKVVKMMIVVVCTFAICWLPFH 265
Cdd:cd15161  157 KASR------GALVSLAVAFTiPFVTTVTCYLLIIRSLRTGK---------REEKPLKDKAIKMIILVLTIFLICFVPYH 221

                 .
gi 568941324 266 I 266
Cdd:cd15161  222 I 222
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
61-316 3.59e-06

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 48.20  E-value: 3.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  61 KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNV-WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ 139
Cdd:cd15302   29 RNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGDyWPLGWVLCDLWLSVDYTVCLVSIYTVLLITIDRYCSVKIPAK 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 140 PRLSATATKVVIFVI--WVLALLLAFPQ----GYYSTTETMPSRVVCMIEWPEHPnrtyekayhicvtvliYFLPLLVIG 213
Cdd:cd15302  109 YRNWRTPRKVLLIIAitWIIPALLFFISifgwQYFTGQGRSLPEGECYVQFMTDP----------------YFNMGMYIG 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 214 YAYT--VVGITLWASeipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLL-------PYINPDLylkkfiq 284
Cdd:cd15302  173 YYWTtlIVMLILYAG---------IYRAANRARKALRTITFILGAFVICWTPYHILATIygfceapPCVNETL------- 236
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568941324 285 qvYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15302  237 --YTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
39-305 4.22e-06

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 47.86  E-value: 4.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  39 YTVIVVTSVVGNVVVIWIILaHKRMRTVTNYFLVNLAFAEACMAafntvVNFTYAVHNV-----WYYGLFYCKFHNFFPI 113
Cdd:cd15969    7 YLIIFIGSILLNGLAVWIFF-HIRNKTSFIFYLKNIVIADLLMT-----LTFPFKIIQDsglgpWNFNFFLCRYTSVLFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 114 AALFASIYSMTAVAFDRYMAIIHPL-QPRL-SATATKVVIFVIWVLALLLAFPQGYYSTTE-TMPSRVVCMIEWPEHPNR 190
Cdd:cd15969   81 ASMYTSIVFLGLISLDRYLKVVKPFgDSRMySITFTKVLSACVWLIMAFLSLPNIILTNGQpTEDNIHDCSKLKSPLGVK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 191 TYEKAYHICVTVLIYFLPLLVIGYaytvvgitLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFH---IF 267
Cdd:cd15969  161 WHTAVSYINICIFVAVLVILIVCY--------ISISRYIYKSSKQFISSSSRTRKHNQSIRVVVAVFFVCFLPYHlcrIP 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568941324 268 FLLPYINP--DLYLKKFIQQVYLASMWLAMSSTMYNPIIY 305
Cdd:cd15969  233 FTFSQLDKilDCTIKTILYYCKEATLFLSACNVCLDPIIY 272
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
35-316 4.55e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 48.00  E-value: 4.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  35 WAAAYTVIVVTSVVGNVvvIWIILA---HKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNV-WYYGLFYCKFHNF 110
Cdd:cd15304    2 WPALLTVIVIILTIAGN--ILVIMAvslEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYrWPLPSKLCAVWIY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 111 FPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVV--IFVIWVLALLLAFPQGYYSTTETmpSRVvcmieWPEHP 188
Cdd:cd15304   80 LDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFlkIIAVWTISVGISMPIPVFGLQDD--SKV-----FKEGS 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 189 NRTYEKAYHICVTVLIYFLPL--LVIGYAYTVVGItlwaseipgdssdryHEQVSAKRKVVKMMIVVVCTFAICWLPFHI 266
Cdd:cd15304  153 CLLADENFVLIGSFVAFFIPLtiMVITYFLTIKSL---------------QQSISNEQKASKVLGIVFFLFVVMWCPFFI 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 568941324 267 FFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15304  218 TNVMAVICKESCNEVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
54-313 7.60e-06

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 47.08  E-value: 7.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFntVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15070   22 IWVVKLNPSLRTTTFYFIVSLALADIAVGVL--VIPLAIVVSLGVTIHFYSCLFMSCLLVVFTHASIMSLLAIAVDRYLR 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIFV--IWVLALLLAFpqgyysttetmpsrvVCMIEWPEHPNRTYEKA-YHIC-------VTVL 203
Cdd:cd15070  100 VKLTVRYRIVTTQRRIWLALglCWLVSFLVGL---------------TPMFGWNRKPSLESVNTtPLQCqftsvmrMDYM 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 204 IYF-------LPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVC-TFAICWLPFHIFFLLPYINP 275
Cdd:cd15070  165 VYFsfftwilIPLVIMCALYVDIFYIIRNKLSQNATGFRETGAFYGREFKTAKSLALVLfLFAVCWLPLSIINCVVYFNP 244
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568941324 276 dlylkKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15070  245 -----KVPKIALYLGILLSHANSMMNPIVYACKIKKFK 277
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
56-266 8.74e-06

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 47.21  E-value: 8.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:cd15977   24 IIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGITVLSLCALSIDRYRAVA 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HPLQPRLSATATK--VVIFVIWVLALLLAFPQGYYSTTETMPSR----VVCMIEwPEHPN---RTYEKAYHICVTVLIYF 206
Cdd:cd15977  104 SWSRIRGIGIPVWkaVEVTLIWAVAIIVAVPEAIAFDMVEIDYRgqtlLVCMLP-MEQTSsfmRFYQDVKDWWLFGFYFC 182
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 207 LPLLVIGYAYTVVGITLWAseIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHI 266
Cdd:cd15977  183 LPLACTGVFYTLMSCEMLS--IKNGMRIALNDHMKQRREVAKTVFCLVVIFALCWLPLHL 240
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
56-165 9.82e-06

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 47.16  E-value: 9.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA-- 133
Cdd:cd15127   24 IVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAat 103
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568941324 134 ---IIHPLQPRLSATATKVVifVIWVLALLLAFPQ 165
Cdd:cd15127  104 nvqMYYEMIENCTSTTAKLA--VIWVGALLLALPE 136
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
54-266 1.13e-05

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 46.63  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEaCMAAFNTVVNFTYAVHNV-WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd15157   22 IYVFLQPSKKKTSVNIFMLNLAVSD-LMFVSTLPFRADYYLMGShWVFGDIACRIMSYSLYVNMYCSIYFLTVLSIVRFL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPLQpRLSATATK---VVIFVIWVLALLLAFPQgYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIyfLPL 209
Cdd:cd15157  101 AIVHPFK-LWKVTSIKyarILCAVIWIFVMAASSPL-LSKGTSKYNSQTKCLDLHPSKIDKLLILNYIVLVVGFI--LPF 176
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568941324 210 LVIGYAYTVVGITLWASEIPgdssdRYHEQVSAKRkVVKMMIVVVCTFAICWLPFHI 266
Cdd:cd15157  177 CTLSICYILIIKALLKPRVP-----QSKLRVSHKK-ALLTIIITLILFLLCFLPYHI 227
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
92-313 1.24e-05

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 46.67  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  92 YAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVI--FVIWVLALLLAFPQGYYS 169
Cdd:cd15147   62 YHNEGNWILPKFLCNVAGCLFFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIisVAIWVIIVASASYFLFMD 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 170 TTETMPSRVVCMIEWPEHPNRTYEKAY---HICVtVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDryheqvSAKRKV 246
Cdd:cd15147  142 STNTVKIDSGNFTRCFEGYEKDNSKPVliiHFII-IGLFFLVFLLILVCNLVIARTLLSQPVQGQRNA------GVKRRA 214
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568941324 247 VKMMIVVVCTFAICWLPFHIfFLLPYINPDLYLKKF--------IQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15147  215 LWMVCTVLAVFVICFVPHHV-VQGPWTLAVLQQWRYwdcqfrqaLNDAHQITLCLMSTNCVLDPVIYCFLTKKFR 288
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
87-162 1.27e-05

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 46.47  E-value: 1.27e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568941324  87 VVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL--QPRLSATATKVVIFVIWVLALLLA 162
Cdd:cd14981   58 VVLAVYASNFEWDGGQPLCDYFGFMMSFFGLSSLLIVCAMAVERFLAITHPFfyNSHVKKRRARLMLGAVWAFALLIA 135
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
57-316 1.64e-05

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 46.49  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRT-VTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFyCKFHNFFPIAALFASIYSMTAVAFDRYMAII 135
Cdd:cd15319   25 VVRFRHLRSkVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAIS 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HPL--QPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEW--PEHP----NRTYEKAYHICVTVLIYFL 207
Cdd:cd15319  104 SPFryERKMTQRVALVMISVAWTLSVLISFIPVQLNWHKDSGDDWVGLHNSsiSRQVeencDSSLNRTYAISSSLISFYI 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 208 PLLVIGYAYT----VVGITL-----------WASEIPGDSSDRYHE---QVSAKRKVVKMMIVVVC--TFAICWLPFHI- 266
Cdd:cd15319  184 PVAIMIVTYTriyrIAQIQIrrissleraaeHAQSCRSNRIDCHHHtslRTSIKKETKVLKTLSVImgVFVCCWLPFFIl 263
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568941324 267 -----FFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYcCLNDRFRLGF 316
Cdd:cd15319  264 ncmvpFCDRPPADPDAGLPCVSETTFDVFVWFGWANSSLNPIIY-AFNADFRKVF 317
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
54-313 2.66e-05

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 45.56  E-value: 2.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEAC-MAAFNTVVNFtYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYM 132
Cdd:cd15366   22 LWAAYLQVRQRNELGVYLLNLSVSDLLyIATLPLWIDY-FLHRDNWIHGPESCKLFGFIFYTNIYISIAFLCCISVDRYL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 133 AIIHPLQ-PRLSATATKVVI-FVIWVLALLL-AFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLiyfLPL 209
Cdd:cd15366  101 AVAHPLRfAKVRRVKTAVAVsAVVWAIEIGAnSAPLFHDELFRDRYNHTFCFEKYPMEDWVAWMNLYRVFVGFL---FPW 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 LVIGYAYTvvGITlwaSEIPGDSSDRYHEQVSAKRkvvkMMIVVVCTFAICWLPFHIFFLLPYInpdLYLKK-----FIQ 284
Cdd:cd15366  178 VLMLFSYR--GIL---RAVRGNVSTEQQEKAKIKR----LALSLIAIVLLCFAPYHVLLLSRSV---VYLGKpcdcgFEE 245
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568941324 285 QV---YLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15366  246 RVftaYHVSLALTSLNCVADPILYCLVNEGAR 277
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
65-218 2.99e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 45.32  E-value: 2.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  65 TVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSA 144
Cdd:cd15214   32 TLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAIDRYYAVLYPMVYPMKI 111
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941324 145 TATKVVIFV--IWVLALLLAFPQGY-YSTTETMPSRVVCMIEWpeHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTV 218
Cdd:cd15214  112 TGNRAVLALvyIWLHSLIGCLPPLFgWSSLEFDRFKWMCVAAW--HKEAGYTAFWQVWCALLPFVVMLVCYGFIFRV 186
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
57-320 3.26e-05

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 45.67  E-value: 3.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACMaafntVVNFTYAVHN---VWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:PHA02834  52 VLIVKRFMFVVDVYLFNIAMSDLML-----VFSFPFIIHNdlnEWIFGEFMCKLVLGVYFVGFFSNMFFVTLISIDRYIL 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIFV-IWVLALLLAFPQGYYSTTETMPSRVVCMIEwPEHPNRTYEKAYHICVTVLIYFLPLLVI 212
Cdd:PHA02834 127 VVNATKIKNKSISLSVLLSVaAWVCSVILSMPAMVLYYVDNTDNLKQCIFN-DYHENFSWSAFFNFEINIFGIVIPLIIL 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 213 GYAYTVVGITLWASEipgdssdryheqvSAKRKVVKMMIVVVCTFA-ICWLPFHIFFLLP------YINPDLY-LKKFIQ 284
Cdd:PHA02834 206 IYCYSKILYTLKNCK-------------NKNKTRSIKIILTVVTFTvVFWVPFNIVLFINslqsvgLIDIGCYhFKKIVY 272
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568941324 285 QVYLASMwLAMSSTMYNPIIYCCLNDRFRLGFKHAF 320
Cdd:PHA02834 273 SIDIAEL-ISFVHCCVNPIIYAFVGKNFKKVFKNMF 307
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
39-313 3.97e-05

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 45.17  E-value: 3.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  39 YTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAafnTVVNFTYAVHNvWYYGLFYCKFHNFFPIAALFA 118
Cdd:cd15920    7 YSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLV---LCLPFRVAYQN-TAGPLSFCKIVGAFFYLNMYA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 119 SIYSMTAVAFDRYMAIIHPLQP------RLSATATKVVifviWVLALLLAFPQGYYSTTETmPSRVVCMiewpEHPNRTY 192
Cdd:cd15920   83 SILFLSLISLDRYLKIIKPLQQfkihtvPWSSAASGGV----WLLLLACMIPFLFESRNEG-PCDNKCF----HFRSKGL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 193 EKAYHICVTVLIYFLPLLVIGYAYTVVGITLWaseipGDSSDRYHEQV-SAKRKVVKMMIVVVCTFAICWLPFHIfFLLP 271
Cdd:cd15920  154 TAGGINLTAVVIFYILSLLFLYFYAKISHKLY-----KVSLGNAQQQIkKASKRAIIKTFIVLAIFIVCFVPYHI-VRVP 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568941324 272 YINPDLYLKKFI---QQVYLASMWLAMSSTM---YNPIIYCCLNDRFR 313
Cdd:cd15920  228 YVLAQIDVISSLpwkQTLHIANELVLCLSALnscLDPIIYFFLSSSFR 275
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
37-305 4.35e-05

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 44.79  E-value: 4.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  37 AAYTVIVVTSVVGNVVVIWIILAHKRmRTVTNYFLVNLAFAEAcmaAFNTVVNFTYAVH---NVWYYGLFYCKFHNFFPI 113
Cdd:cd15371    5 AVYIIVVVLGVPSNAIILWMLFFRLR-SVCTAIFYANLAISDL---LFCITLPFKIVYHlngNNWVFGETMCRIITITFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 114 AALFASIYSMTAVAFDRYMAIIHPLQPR--LSATATKVVIFVIWVLALLLAFP-----QGYYSTTetmPSRVVCMIEWPE 186
Cdd:cd15371   81 GNMYCSILLLTCISINRYLAIVHPFIYRslPKKTYAVLICALVWTIVFLYMLPffilkQTYYLKE---LNITTCHDVLPE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 187 HPNRTYEKAYH-ICVTVLIYFLPLLVIGYAYTVVGITLWASEipgdssdryHEQVSAKRKVVKMMIvvvcTFAICWLPFH 265
Cdd:cd15371  158 CEQNSNFQFYYfISMAVFGFLIPLVITIFCYISIIRTLNAYE---------HKWFWYVKITALVLI----IFTICFAPSN 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568941324 266 IFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIY 305
Cdd:cd15371  225 VILIIHHFNYYYFNNDNLYSIYLIALCLGSLNSCLDPFLY 264
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
66-219 5.35e-05

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 44.45  E-value: 5.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  66 VTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ--PRLS 143
Cdd:cd15215   33 VANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSypTKMT 112
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941324 144 ATATKVVIFVIWVLALLLAFPQGY-YSTTETMPSRVVCMIEWPEHPnrtyekAYHICVTVLIYFLPLLVIGYAYTVV 219
Cdd:cd15215  113 PRRGYLLIYGTWIVSVLQSTPPLYgWGQAAFDERNALCSVIWGSSY------SYTILSVVSSFVLPVIIMLACYSMV 183
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
58-313 7.86e-05

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 44.05  E-value: 7.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  58 LAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTyaVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAII-- 135
Cdd:cd14989   26 LSFREKMTIPDLYFVNLAVADLILVADSLIEVFN--LNEKYYDIAVLCTFMSLFLQINMYSSIFFLTWMSFDRYIALAkv 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 ---HPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRV--VCMIEWPEhpnrtyekayhicvTVLIYFLPLL 210
Cdd:cd14989  104 mksSPLRTMQHARLSCGLIWMASISATLLPFTAVQAQHTGEVHFCFadVREIQWLE--------------VTLGFIIPFS 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 211 VIGYAYTVVGITLWASEipgdssdrYHEQVSAKRKVVK-MMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLA 289
Cdd:cd14989  170 IIGLCYSLIVRVLVRAQ--------KHRRLRPRRQKALrMILVVVLVFFICWLPENVFISIQLLQGTQEPSESYDESFRH 241
                        250       260       270
                 ....*....|....*....|....*....|..
gi 568941324 290 SMWL--------AMSSTMYNPIIYCCLNDRFR 313
Cdd:cd14989  242 NHPLtghivnlaAFSNSCLNPLIYSFLGETFR 273
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
56-164 8.33e-05

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 44.17  E-value: 8.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAfntvVNFTYAVHNV-----WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15217   24 LVLKDRALHKAPYYFLLDLCLADTIRSA----VCFPFVLVSIrngsaWTYSVLSCKIVAFMAVLFCFHAAFMLFCISVTR 99
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568941324 131 YMAIIHP--LQPRLSATATKVVIFVIWVLALLLAFP 164
Cdd:cd15217  100 YMAIAHHrfYSKRMTFWTCIAVICMVWTLSVAMAFP 135
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
98-313 1.11e-04

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 43.62  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  98 WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRL--SATATKVVIFVIWVLALLLAFPQGYYSTTETMP 175
Cdd:cd15151   65 WQLRAFVCRFSAVVFYITMYISIILLGLISFDRYLKIVRPFGKSWvqRVRFAKILSGAVWLVMFLLSVPNMILSNKPATP 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 176 SRVV-CMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIgyAYTVVGITLWASEIPGDSSDRyheqvSAKRKVVKMMIVVV 254
Cdd:cd15151  145 ISVKkCASLKSPLGLKWHEVVNYICQFIFWGVFALMVL--FYTIISKKVYESYKKSRSKDN-----KASKKTKAKVFIIV 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568941324 255 CTFAICWLPFHiFFLLPYINPDLYLKKFIQ---QVYLA---SMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15151  218 AVFFVCFAPFH-FVRVPYTLSQTGKITDCQlqnLLYIAkeiTLWLAATNVCLDPLIYIFLCKSFR 281
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
54-138 1.22e-04

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 43.54  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMA---AFNTVVNFTYAVHNVWYYGlfyCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15412   22 ILLIRLDSRLHTPMYFFLSHLSFVDLCYSsnvTPKMLVNFLSEKKTISFAG---CFTQCYFFIALVITEYYMLAVMAYDR 98

                 ....*...
gi 568941324 131 YMAIIHPL 138
Cdd:cd15412   99 YMAICNPL 106
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
39-305 1.28e-04

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 43.60  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  39 YTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACmaaFNTVVNFTYAVH---NVWYYGLFYCKFHNFFPIAA 115
Cdd:cd15369    7 YTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLL---FVLLLPFKIAYHfsgNDWLFGEAMCRVVTAAFYCN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 116 LFASIYSMTAVAFDRYMAIIHPLQPRLSATATK--VVIFVIWVLALLLAFPQGYYSTTETMP--SRVVCMIEWPEHPNRT 191
Cdd:cd15369   84 MYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRasFTCAAIWLLSIAGVVPLLLSEQTIQIPdlGITTCHDVLNEQLLMG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 192 YEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAkrkvvkmmIVVVCTFAICWLPFHIFFLLP 271
Cdd:cd15369  164 YYVYYFSIFSCLFFFVPLIITTVCYVSIIRCLSSSSDVANSSKKTRALFMA--------VAVFCVFVICFGPTNVLLLAH 235
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568941324 272 YIN-PDLYLKKFIQQVYLASMWLAMSSTMYNPIIY 305
Cdd:cd15369  236 YVRfAYTSTNDASYFAYLLCVCVGSISCCLDPLIY 270
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
56-164 2.21e-04

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 43.10  E-value: 2.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAA------FNTVVNftyavHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFD 129
Cdd:cd15218   24 LLVKDKTLHRAPYYFLLDLCCSDILRSAicfpfvFTSVKN-----GSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVT 98
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568941324 130 RYMAIIHP--LQPRLSATATKVVIFVIWVLALLLAFP 164
Cdd:cd15218   99 RYLAIAHHrfYTKRLTFWTCLAVICMVWTLSVAMAFP 135
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
54-305 2.76e-04

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 42.35  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMA 133
Cdd:cd15201   22 LWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFRTDYYLRGKHWKFGDIPCRIVLFMLAMNRAGSIFFLTAVAVDRYFR 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 134 IIHPLQPRLSATATKVVIF--VIWVL-----ALLLAFPQGYYSTTETM-PSRVVCMieWPEHPNRTYEKAYhicvtVLIY 205
Cdd:cd15201  102 VVHPHHRINSISVRKAAIIacGLWLLtiamtVYLLTKKHLFPRGNATQcESFNICT--GTDSSSNWHEAMF-----LLEF 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 206 FLPLLVIgyAYTVVGITLwasEIPGDSSDRyHEQVsakRKVVKMMIVVVCTFAICWLP-----FHIFFLLPYINPDLYLK 280
Cdd:cd15201  175 FLPLAII--LYCSVRIIW---QLRGRQLDR-HAKI---KRAVQFIMVVAIVFIICFLPsnvtrIAIWILKHTSNEDCQYY 245
                        250       260
                 ....*....|....*....|....*
gi 568941324 281 KFIQQVYLASMWLAMSSTMYNPIIY 305
Cdd:cd15201  246 RSVDLAFYITISFTYFNSMLDPVVY 270
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
95-306 3.08e-04

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 42.06  E-value: 3.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  95 HNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPL---QPRLSATATKVVIfVIWVLALLLA---FPQGYY 168
Cdd:cd15367   63 HDNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFrfhAFRTMKAATLVST-VIWLKELMTCvffFLHGEI 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 169 STTETmpSRVVCMIEWPEHPNRTYEKAYHICVTVLiyfLPLLVIGYAYTVVGITLWASEipgdsSDRYHEQVSAKRKVVK 248
Cdd:cd15367  142 SKDKE--NHSVCFEHYPIKAWEHNINYYRFYAGFL---FPIFLLSFSYCRILRAVRKSH-----GTQKSQKIQIKRLVLS 211
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568941324 249 MMIvvvcTFAICWLPFHIFFLLPYI-NPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYC 306
Cdd:cd15367  212 TVV----IFLVCFGPYHILLLVRSVfERDCNFAEGIFNYYHFSLLLTSFNCVADPVLYC 266
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
62-273 3.22e-04

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 42.25  E-value: 3.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  62 RMR--TVTNYFLVNLAFAEACMAAFNTVVnfTYAVHNVWYYGLFyCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQ 139
Cdd:cd15164   28 KMKkwTETRVYMINLAVADCCLLFSLPFV--LYFLKHSWPDDEL-CLVLQSIYFINRYMSIYIITAIAVDRYIAIKYPLK 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 140 ------PRLSATATKVV-IFVIWVLALLLAFPQgyysttetmpsrvvcmiewpEHPNRTYEKAYH------ICVTVLIYF 206
Cdd:cd15164  105 akslrsPRKAALTCGLLwVLVIISVSLRLAWEE--------------------QEENFCFGKTSTrpskrtLIFSLLGFF 164
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941324 207 LPLLVIGYAYTVVGITLwaseIPGDSSDRYHEQVSAKrkVVKMMIVVVCTFAICWLPFHIFFLLPYI 273
Cdd:cd15164  165 IPLIILSFCSIQVIRSL----KKKKKTNPHEEKLIQK--AIYIVSANLIVFIVCFLPLHIGLLVRFV 225
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
38-164 3.74e-04

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 42.06  E-value: 3.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  38 AYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNvWYYGLFYCKFHNFFPIAALF 117
Cdd:cd15154    6 GYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHY-WPFGNFLCQFSGSIFQMNMY 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568941324 118 ASIYSMTAVAFDRYMAIIHPLQPR--LSATATKVVIFVIWVLALLLAFP 164
Cdd:cd15154   85 GSCLFLMCINVDRYLAIVHPLRFRhlRRPKVARLLCLAVWALILGGSVP 133
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
54-305 7.71e-04

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 40.98  E-value: 7.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNY-FLVNLAFAEACMAAFNTVVNFTYAV-HNVWYYGLFYCKFHNFfpIAALFASIYSMTAVAFDRY 131
Cdd:cd15099   22 LLTILSSTALRRRPSYlFIGSLALADMLASVIFTISFLDFHVfHQRDSRNLFLFKLGGV--TMAFTASVGSLLLTALDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 132 MAIIHPLQPRLSATATK--VVIFVIWVLALLLAFPQGYYSTTETMPSrvVCMIEWPeHPNRTYEKAYHICVTVLIYFlpl 209
Cdd:cd15099  100 LCIYQPSNYKLLVTRTRakVAILLMWCVTIIISFLPLMGWRCKTWDS--PCSRLFP-YIDRHYLASWTGLQLVLLFL--- 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 210 lvIGYAYtvvGITLW---------ASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPfhiffLLPYINPDLY-- 278
Cdd:cd15099  174 --IIYAY---PYILWkahrheanmGGPKLGRQQVKGQARMRMDIRLAKTLSLILLVLAICWLP-----VLAFMLVDVRvt 243
                        250       260
                 ....*....|....*....|....*..
gi 568941324 279 LKKFIQQVYLASMWLAMSSTMYNPIIY 305
Cdd:cd15099  244 LTNKQKRMFAFCSMLCLVNSCVNPIIY 270
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
57-162 8.56e-04

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 40.89  E-value: 8.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACM-AAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFasiySMTAVAFDRYMAII 135
Cdd:cd15905   23 IACNRKLHNTANYFFLSLLLADLLTgVALPFIPGMSNESRRGYHSCLFVYVAPNFLFLSFLA----NLLMVHYERYLCIV 98
                         90       100
                 ....*....|....*....|....*....
gi 568941324 136 HPLQPRLSAT--ATKVVIFVIWVLALLLA 162
Cdd:cd15905   99 YPLQYHNFWVhrWVPLALLLTWALPLLFA 127
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
53-138 1.09e-03

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 40.43  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  53 VIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNT---VVNFTYAVHNVWYYGlfyCKFHNFFPIAALFASIYSMTAVAFD 129
Cdd:cd15406   30 MILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITpkmLVNFVSEKNIISYPE---CMTQLFFFCVFAIAECYMLTAMAYD 106

                 ....*....
gi 568941324 130 RYMAIIHPL 138
Cdd:cd15406  107 RYVAICNPL 115
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
98-313 1.71e-03

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 39.83  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  98 WYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRL--SATATKVVIFVIWVLALLLAFPQGYYSTTETMP 175
Cdd:cd15149   65 WQLNVIVCRYSAVIFYLNMYVGIIFFGLIGFDRYYKIVKPLHTSFvqNVGYSKALSVVVWMLMAVLSVPNIILTNQSFHE 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 176 SRVVCMIEWPEHPNRTYEKAY-HICVTVLIYFLPLLVIgyAYTVVGITLWASEIPGDSSDryheqVSAKRKVVKMMIVVV 254
Cdd:cd15149  145 ANYTKCARLKSELGIQWHKASnYICVSIFWVVFLLLII--FYVAISRKIYKSNQKFRRNS-----TNMKAKSSRNIFSIL 217
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568941324 255 CTFAICWLPFHIfFLLPYINPDL------YLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFR 313
Cdd:cd15149  218 FVFFVCFVPYHA-LRIPYTLSQTgadyscQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFR 281
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
54-139 1.73e-03

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 40.08  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNT---VVNFTYAVHNVWYYGlfyCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15409   22 IALIWKDSHLHTPMYFFLGNLAFADACTSSSVTpkmLVNFLSKNKMISFSG---CAAQFFFFGFSATTECFLLAAMAYDR 98

                 ....*....
gi 568941324 131 YMAIIHPLQ 139
Cdd:cd15409   99 YVAICNPLL 107
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
41-316 2.34e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 39.45  E-value: 2.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  41 VIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFntVVNFTYAVhNVWYYGLFYCKFHNFFPIAALF-AS 119
Cdd:cd15071    9 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGAL--VIPLAIII-NIGPQTEFYSCLMVACPVLILTqSS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 120 IYSMTAVAFDRYMAIIHPLQPRLSATATK--VVIFVIWVLALLLAFP-----------QGYYSTTETMPSRVV-CMIEwp 185
Cdd:cd15071   86 ILALLAIAVDRYLRVKIPTRYKSVVTPRRaaVAIAGCWILSFLVGLTpmfgwnnlnavERAWAANSSMGELVIkCQFE-- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 186 ehpnRTYEKAYHICVTVLIYFLP---LLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWL 262
Cdd:cd15071  164 ----TVISMEYMVYFNFFVWVLPpllLMLLIYLEVFYLIRKQLNKKVSSSSSDPQKYYGKELKIAKSLALILFLFALSWL 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568941324 263 PFHIFFLLPYINPDLYLKKFIqqVYLAsMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15071  240 PLHILNCITLFCPSCKKPMIL--TYIA-IFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
113-305 2.36e-03

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 39.38  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 113 IAALFASIYSMTAVAFDRYMAIIHPL--QPRLSATATKVVIFVIWVLALLL-AFPQGYYSTtetMPSRVVCMIEWPEHPN 189
Cdd:cd15100   77 VAAFSASVCSLLAITVDRYLSLYNALtyYSERTLTFTYVMLALLWTLALGLgLLPVLGWNC---LREGSSCSVVRPLTKN 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 190 rtyekayHICVTVLIYFLPLLVIGYAYTVVGITLW--ASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIF 267
Cdd:cd15100  154 -------HLAVLAVAFLLVFALMLQLYAQICRIVLrhAHQIALQRHFLAPSHYVATRKGVSTLALILGTFAACWIPFAVY 226
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 568941324 268 FLL-PYINPDLYLkkfiqqvyLASMWLAMSSTMYNPIIY 305
Cdd:cd15100  227 CLLgDGSSPALYT--------YATLLPATYNSMINPIIY 257
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
93-216 2.56e-03

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 39.34  E-value: 2.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  93 AVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATA--TKVVIFVIWV-------LALLLAF 163
Cdd:cd14983   61 ALSSAWTLPAVLCPLYNLAHFSTLYASTCFLTAISAGRYLGVAFPIKYQLYKKPlySCLVCVAIWAlvifhvtLVFILET 140
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568941324 164 PQGYYSTTETMPSRVVCMIEW-PEHPNRTYEKAYHICvtVLIYFLPLLVIGYAY 216
Cdd:cd14983  141 SGGTLDINTPVGNSSTCYENFtPEQLALLAPVRLELS--LVLFFLPLAITAFCY 192
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
57-316 3.20e-03

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 38.99  E-value: 3.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  57 ILAHKRMRTVTNYFLVNLAFAEACM-AAFNTVVNFTYAVHNVWYYGLFYCKFHNFFpiAALFASIYSMTAVAFDRYMAII 135
Cdd:cd15102   25 IWRHMKFHRPMYYFLGNLALSDLLAgAAYLANILLSGARTLRLSPAQWFLREGSMF--VALSASVFSLLAIAIERHLTMA 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 136 HP-LQPRLSATATKVVIFVIWVLALLL-AFPQGYYSTTETMPSrvvCMIEWPehpnrTYEKAYHICVtVLIYFLPLLVIG 213
Cdd:cd15102  103 KMkPYGASKTSRVLLLIGACWLISLLLgGLPILGWNCLGALDA---CSTVLP-----LYSKHYVLFC-VTIFAGILAAIV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 214 YAYTVVGITLWASEIpgdsSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLpyinpDLYLKKFIQQVYLASMW- 292
Cdd:cd15102  174 ALYARIYCLVRASGR----KATRASASPRSLALLKTVLIVLLVFIACWGPLFILLLL-----DVACPVKTCPILYKADWf 244
                        250       260
                 ....*....|....*....|....*.
gi 568941324 293 --LAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15102  245 laLAVLNSALNPIIYTLRSRELRRAV 270
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
115-316 3.35e-03

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 39.09  E-value: 3.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 115 ALFASIYSMTAVAFDRYMAIIH-PLQPRLSATATKVVIFVIWVLALLLA-FPQGYYSTTETMPSrvvCMIEWPehpnrTY 192
Cdd:cd15346   82 ALSASVFSLLAIAIERYITMLKmKLHNGSNSFRSFLLISACWVISLILGgLPIMGWNCISALSS---CSTVLP-----LY 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 193 EKAYHI-CVTVLIYFLPLLVIGYA--YTVVGiTLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFL 269
Cdd:cd15346  154 HKHYILfCTTVFTLLLLSIVILYCriYSLVR-TRSRRLTFRKNIRKASRSSEKSMALLKTVIIVLSVFIACWAPLFILLL 232
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568941324 270 LpyinpDLYLKKFIQQVYLASMW---LAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15346  233 L-----DVGCKVKTCSILFKAEYflvLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
54-165 4.10e-03

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 38.62  E-value: 4.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACmaaFNTVV------NFTYAVHNVWYYGLF-YCKFHNFFPIAALFAsiysMTAV 126
Cdd:cd15912   22 ITITLVDHRLHTPMYFFLRNFSFLEIL---FTSVVipkmlaNLLSGKKTISFAGCFaQSFFYFFLGTTEFFL----LAVM 94
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568941324 127 AFDRYMAIIHPLQ------PRLSAtatkVVIFVIWVLALLLAFPQ 165
Cdd:cd15912   95 SFDRYVAICNPLHyptimnSRVCL----QLVLGSWVGGFLLILPP 135
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
54-138 4.52e-03

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 38.57  E-value: 4.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMAAFNT---VVNFTYAVHNVWYYGlfyCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15945   35 IILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGpkmLVDLLAKRKSIPFYG---CALQMFFFAAFADAECLLLAVMAYDR 111

                 ....*...
gi 568941324 131 YMAIIHPL 138
Cdd:cd15945  112 YVAICNPL 119
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
54-316 5.04e-03

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 38.59  E-value: 5.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACMA---AFNTVVNFTYAVhnvWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDR 130
Cdd:cd15167   22 LWAFIQKRSSRKCINIYLINLLTADFLLTlalPVKIAVDLGIAP---WKLKIFHCQVTACLIYINMYLSIIFLGFVSIDR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 131 YMAIIHPLQ-PRLSATA-TKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEK-AYHICVTVLIYFL 207
Cdd:cd15167   99 YLQLTHSSKlYRIQEPGfAKMISAVVWTLVLFIMVPNMAIPIKTIEEKPGVGCADFKTEFGRHWHVlTNFICMAIFLNFS 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 208 PLLVIGYAYTVVgiTLWASEIPGDSSDRYHEQVSakrkvvkmMIVVVCTFAICWLPFHIF---FLLPYINP--DLYLKKF 282
Cdd:cd15167  179 AIILISNFLVIR--KLYRNKDSEEYRNARQALVN--------ILLVTAGYVICFVPYHIVripYTLSQSEVitDCSLKRS 248
                        250       260       270
                 ....*....|....*....|....*....|....
gi 568941324 283 IQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGF 316
Cdd:cd15167  249 LFLAKESTLLLAVLNLCFDPILYFHLSKAFRSKI 282
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
39-313 5.56e-03

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 38.63  E-value: 5.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  39 YTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPI----A 114
Cdd:cd14996    7 YSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFYWKYQSTQCRIANFFGTlvihV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 115 ALFASIYSMTAVAFDRYMAII------------------HPLQPRLSATATKVVIFVIWVLALLLAFP-QGYYSTTE-TM 174
Cdd:cd14996   87 SMCVSILILSWIAISRYATLMkhdsatqkqscyekifygHFLKRFRQPKFARYLCIYIWGVVLCIIIPvVVYYSVREaDE 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 175 PSRVVCMIEWPEHPNRTYEKAYHICVTvLIYFLPLLVIGYAYTVVGiTLWASEIPGDSSDRYHEQVSAKRKVVKMMIVvv 254
Cdd:cd14996  167 DGESLCYNRQVELGAKGSQIAGLIATT-FFFLFFLVVLLSYYSFVN-HLRRIQKNTCISEKDLIYRSVKRNILIIQAL-- 242
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568941324 255 ctFAICWLPFHIFFLLPYInpdLYLKKFIQQV--------YLASMWLAMSSTmyNPIIYCCLNDRFR 313
Cdd:cd14996  243 --LVVCFLPYHIFKPVFYV---LHQREDCQQLnylietknILTCLASARSST--DPIMYLLLDKTFK 302
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
54-163 5.78e-03

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 38.35  E-value: 5.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACM-------AAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAV 126
Cdd:cd15964   22 LLILLTSHYKLTVPRFLMCNLAFADFCMgiyllliASVDLHTRSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVI 101
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568941324 127 AFDRYMAIIHPLQP--RLSATATKVVIFVIWVLALLLAF 163
Cdd:cd15964  102 TLERWYAITFAMRLdrKIRLRHASAIMLGGWVFCFLLAL 140
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
54-139 6.51e-03

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 38.01  E-value: 6.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFaeacMAAFNTVVNFTYAVHNVW-------YYGlfyCKFHNFFPIAALFASIYSMTAV 126
Cdd:cd15232   22 ILAISTSPKLHTPMYFFLVNLSL----VDIICTSTVVPKLLQNLLterktisFGG---CMAQLYFFTWSLGSELLLLTAM 94
                         90
                 ....*....|...
gi 568941324 127 AFDRYMAIIHPLQ 139
Cdd:cd15232   95 AYDRYVAICHPLH 107
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
56-234 6.76e-03

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 37.92  E-value: 6.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  56 IILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVN----------FTYAVHnvWYYGLfYCKFHNFFPIAALFASIYSMTA 125
Cdd:cd15360   24 ILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIAsvdirtksqyYNYAID--WQTGA-GCAAAGFFTVFASELSVYTLTV 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 126 VAFDRYMAIIHPLQ--PRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSrvVCMiewPEHPNRTYEKAYHICVTVL 203
Cdd:cd15360  101 ITLERWHTITYAMQldRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVS--ICL---PMDIESPLSQAYIIFILVL 175
                        170       180       190
                 ....*....|....*....|....*....|.
gi 568941324 204 iYFLPLLVIGYAYTVVGITLWASEIPGDSSD 234
Cdd:cd15360  176 -NVLAFLIICACYIKIYLTVRNPNFVSSNSD 205
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
54-162 7.30e-03

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 37.92  E-value: 7.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324  54 IWIILAHKRMRTVTNYFLVNLAFAEACM-------AAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAV 126
Cdd:cd15359   22 LFVLLTSRYKLTVPRFLMCNLSFADFCMglyllliASVDSQTKSQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVI 101
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568941324 127 AFDRYMAIIHPLQ--PRLSATATKVVIFVIWVLALLLA 162
Cdd:cd15359  102 TLERWHTITYAMQldRKLRLRHAILIMLGGWVFSLLIA 139
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
115-305 9.35e-03

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 37.46  E-value: 9.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 115 ALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVI--WVLALLLAFpqgyystTETMPSRVVCMIEWPEHPNRTY 192
Cdd:cd15349   82 ALAASTFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVlcWILAFLIGF-------LPLLGWNCLCDFRSCSSLLPLY 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941324 193 EKAYhICVTVLIYFLPLLVIGYAYTVVGITLWASeipGDSSDRYHEQVSAKRKVVKMMIVVVcTFAICWLPFHIFFLLpy 272
Cdd:cd15349  155 SKSY-ILFCLVIFFIILLTIIGLYFAIYCLVRAS---GQRVISARSRRRSLRLLKTVLMILG-AFMVCWGPLFILLLV-- 227
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 568941324 273 inpDLYLKKFIQQVYLASMW---LAMSSTMYNPIIY 305
Cdd:cd15349  228 ---DFFCSSRSCKPLFGMEWvlaLAVLNSAINPLIY 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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