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Conserved domains on  [gi|568944148|ref|XP_006506991|]
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alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2 [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 1-263 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467717  Cd Length: 272  Bit Score: 554.83  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148   1 MEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGCGRQIDEANF 80
Cdd:cd23989   10 LEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGCGQQIDRADF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  81 VMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKD 160
Cdd:cd23989   90 VMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVYYTLAD 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 161 VGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLPFSGY 240
Cdd:cd23989  170 VGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLPDSGF 249

                        250       260
                 ....*....|....*....|...
gi 568944148 241 HAMPEEFLQLWYLHKIGALRMQL 263
Cdd:cd23989  250 HAMPEEFLQLWHLHKSGVLRMQL 272
 
Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 1-263 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 554.83  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148   1 MEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGCGRQIDEANF 80
Cdd:cd23989   10 LEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGCGQQIDRADF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  81 VMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKD 160
Cdd:cd23989   90 VMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVYYTLAD 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 161 VGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLPFSGY 240
Cdd:cd23989  170 VGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLPDSGF 249

                        250       260
                 ....*....|....*....|...
gi 568944148 241 HAMPEEFLQLWYLHKIGALRMQL 263
Cdd:cd23989  250 HAMPEEFLQLWHLHKSGVLRMQL 272
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 13-258 5.69e-103

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 300.29  E-value: 5.69e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148   13 MTKMNSPMGKSLWYdGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsS 91
Cdd:pfam00777   2 LTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT-K 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148   92 EYTRDVGSKTQLVTANP-SIIRQRFENLLWS--RKKFVDNMKIYNH--SYIYMPAFSMKTGTEPSLRVYYTLKDVGANQT 166
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  167 ---VLFANPNFLRNIGKFW-KSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFsvnMQGDPISHHYYDNVLP----FS 238
Cdd:pfam00777 160 pdkVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMkkggFY 236

                         250       260
                  ....*....|....*....|
gi 568944148  239 GYHAMPEEFLQLWYLHKIGA 258
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 1-263 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 554.83  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148   1 MEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGCGRQIDEANF 80
Cdd:cd23989   10 LEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGCGQQIDRADF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  81 VMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKD 160
Cdd:cd23989   90 VMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVYYTLAD 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 161 VGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLPFSGY 240
Cdd:cd23989  170 VGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLPDSGF 249

                        250       260
                 ....*....|....*....|...
gi 568944148 241 HAMPEEFLQLWYLHKIGALRMQL 263
Cdd:cd23989  250 HAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 1-263 9.50e-165

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 457.10  E-value: 9.50e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148   1 MEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEAN 79
Cdd:cd23971   10 LRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSnKPLKTCAVVGNGGILKNSSCGREIDSAD 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  80 FVMRCNLPPLSseYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLK 159
Cdd:cd23971   90 FVIRCNLPPLN--DSKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPSLRALYTLE 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 160 DVGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLPFSG 239
Cdd:cd23971  168 DFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHYYDNVLPKKG 247

                        250       260
                 ....*....|....*....|....
gi 568944148 240 YHAMPEEFLQLWYLHKIGALRMQL 263
Cdd:cd23971  248 VHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 4-263 7.99e-115

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 330.95  E-value: 7.99e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148   4 CCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVM 82
Cdd:cd23991   13 CCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRgYPYKQCAVVGNGGILKNSSCGAEIDQADFVF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  83 RCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKDVG 162
Cdd:cd23991   93 RCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALSFKVYYTLEDFK 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 163 ANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLPFSGYHA 242
Cdd:cd23991  173 AKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQLPKPGFHS 252

                        250       260
                 ....*....|....*....|.
gi 568944148 243 MPEEFLQLWYLHKIGALRMQL 263
Cdd:cd23991  253 MPKEFYQLLQLHSKGILKLQF 273
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 2-263 2.44e-106

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 309.58  E-value: 2.44e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148   2 EDCCDPAHLFAmTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPF-QLPLKKCAVVGNGGILKMSGCGRQIDEANF 80
Cdd:cd23963   11 ERLLNTRKLFL-TQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFsHKRYKTCAVVGNSGILLGSGCGKEIDSHDF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  81 VMRCNLPPLSsEYTRDVGSKTQLVTANPSIIRQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTL 158
Cdd:cd23963   90 VIRCNLPPIK-GFEKDVGRKTNLTTLNPSILKRRYNSLKknRDRDKFLNRLKEYNGSILWYPKFSFKSSTNLLLKAARAL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 159 KDVGANQTVLFANPNFLRNIGKFWKSRGIhAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLP-- 236
Cdd:cd23963  169 KKNGLNLTVVYSNPEHFLAVQKFWKRRGL-EKRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHYYDDLSPst 247

                        250       260
                 ....*....|....*....|....*..
gi 568944148 237 FSGYHAMPEEFLQLWYLHKIGALRMQL 263
Cdd:cd23963  248 KNKVHNMPEEFKLLRELHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 13-258 5.69e-103

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 300.29  E-value: 5.69e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148   13 MTKMNSPMGKSLWYdGELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsS 91
Cdd:pfam00777   2 LTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT-K 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148   92 EYTRDVGSKTQLVTANP-SIIRQRFENLLWS--RKKFVDNMKIYNH--SYIYMPAFSMKTGTEPSLRVYYTLKDVGANQT 166
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  167 ---VLFANPNFLRNIGKFW-KSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFsvnMQGDPISHHYYDNVLP----FS 238
Cdd:pfam00777 160 pdkVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMkkggFY 236

                         250       260
                  ....*....|....*....|
gi 568944148  239 GYHAMPEEFLQLWYLHKIGA 258
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 4-261 1.33e-96

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 284.81  E-value: 1.33e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148   4 CCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPF-QLPLKKCAVVGNGGILKMSGCGRQIDEANFVM 82
Cdd:cd23990   13 CCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYsRSQFKKCAVVGNGGILKNSKCGREIDSADFVF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  83 RCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKDVG 162
Cdd:cd23990   93 RCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVSIRVKYVLDDFE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 163 ANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLPFSGYHA 242
Cdd:cd23990  173 SQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYYDNVKPRPGFHA 252

                        250
                 ....*....|....*....
gi 568944148 243 MPEEFLQLWYLHKIGALRM 261
Cdd:cd23990  253 MPSEIFNFLHMHSRGILRV 271
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 6-263 3.46e-72

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 223.04  E-value: 3.46e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148   6 DPAHLFAMTKMNSPMGKSLWYD-GELLYSFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMR 83
Cdd:cd23970   18 DVIKNISLTKKDVRIGQLMHFDySSHKYVFSISPNLRSLLPEVSPFQnKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFR 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  84 CNLPPLSSeYTRDVGSKTQLVTANPSIIRQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKDV 161
Cdd:cd23970   98 CNFAPTEG-FEKDVGRKTNLTTFNPSILEKYYNNLLtiQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEH 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 162 GANQTVLFANP-NFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDN-----VL 235
Cdd:cd23970  177 RGQLKVQLAWPgNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGTPLPYHYYDKkgtkfTT 256

                        250       260
                 ....*....|....*....|....*...
gi 568944148 236 PFSGYHAMPEEFLQLWYLHKIGALRMQL 263
Cdd:cd23970  257 KWQESHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 6-262 1.14e-69

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 216.51  E-value: 1.14e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148   6 DPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPL-KKCAVVGNGGILKMSGCGRQIDEANFVMRC 84
Cdd:cd23969   15 DPEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHfRTCAVVGNSGILLNSGCGQEIDSHDFVIRC 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  85 NLPPLSsEYTRDVGSKTQLVTANPSIIRQRFENLLWS--RKKFVDNMKIYNHSYIYMPAFSMKTGTEpslRVYYTLKDV- 161
Cdd:cd23969   95 NLAPVE-GYEKDVGTKSNLTTMNPSVIPHAYGDLVNAtdKEKFVERLRQLGDSILWIPAFVSKGGEE---HVQWTNEIIl 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 162 --GANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNvLPFS- 238
Cdd:cd23969  171 khKLNVKTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHYYDN-RKYLt 249

                        250       260
                 ....*....|....*....|....*.
gi 568944148 239 --GYHAMPEEFLQLWYLHKIGALRMQ 262
Cdd:cd23969  250 taRPHKMPEEFRALRSLHQRGALRLH 275
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 33-261 1.27e-57

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 185.53  E-value: 1.27e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  33 SFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSsEYTRDVGSKTQLVTANPSII 111
Cdd:cd23987   42 TMNISQNLYELLPRTSPLKnKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVE-EYAKDVGTKTDLVTMNPSVV 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 112 RQRFENLL---WsRKKFVDNMKIYNHSYIYMPAFSMKTGTEpslRVYYTLKDV---GANQTVLFANPNFLRNIGKFWKSR 185
Cdd:cd23987  121 QRAFEDLVnetW-KEKFLQRLQSLNGSILWIPAFMAKGGEE---RVEWVNDLIlkhHINVRTAYPSLRLLHAVRGYWLTN 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 186 GIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNV----LPFSGYHAMPEEFLQLWYLHKIGALRM 261
Cdd:cd23987  197 KVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLkygyTSQASPHTMPLEFKALKNLHQQGALKL 276
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 33-261 3.00e-54

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 177.07  E-value: 3.00e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  33 SFTIDNSTYSLFPQATPFQ-LPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSsEYTRDVGSKTQLVTANPSII 111
Cdd:cd23988   42 TLNISQNLHSLLPEVSPMKnRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVV-EFAADVGTKSDFITMNPSVV 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 112 RQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMKTGTEpslRVYYTLKDVGANQ-TVLFANPNF--LRNIGKFWKSRG 186
Cdd:cd23988  121 QRAFGGFRneSDREKFVHRLSMLNDSVLWIPAFMVKGGEK---HVEWVNALILKNKlKVRTAYPSLrlIHAVRGYWLTNK 197

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568944148 187 IHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNV----LPFSGYHAMPEEFLQLWYLHKIGALRM 261
Cdd:cd23988  198 VNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLkyryFSNAGPHRMPLEFKTLNVLHNRGALKL 276
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 57-247 4.29e-28

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 106.68  E-value: 4.29e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  57 CAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYnhsY 136
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAP-TKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPLEEEVV---L 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 137 IYMPAFsmktgTEPSLRVYYTLKDVGANQT-VLFANPNF-------LRNIGKFWKSRGIHAkrlSTGLFLVSAALGLCEE 208
Cdd:cd19952   77 ILSRAA-----AADFKRLKRRKKRHDNAVLlLTDPAPDLlsyvrkrLEKLGLKSFFGGNAP---SSGLLAVLLALQLCDS 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 568944148 209 VSIYGFWPFSVNMQGDPisHHYYDNVLP--FSGYHAMPEEF 247
Cdd:cd19952  149 VDLYGFGVDSGHAPKVP--YHYYDLVEAeeGTAVHSFDLEA 187
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 56-260 1.17e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 102.34  E-value: 1.17e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  56 KCAVVGNGGILKMSGCGRQIDEANFVMRCNLpPLSSEYTRDVGSKTQLVTANP--SIIRQRFENLLWSRKKFVDNM-KIY 132
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNH-ALTKGFEKDVGTKTSFYTFFPesLHNSLLKHVPQDKDTKYLFIPfKIR 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 133 nhSYIYMPAFS----MKTGTEPSLRVYYTLKDVGANQTVLFANPNFLRNIGKFW-KSRGIHakRLSTGLFLVSAALGLCE 207
Cdd:cd23964  163 --DYDYLDAVLsgkpVPDGCDKGKRPPPLFGPKLNATNVRLLHPDFIRYLFNRWlNSSTSY--RPTTGALMLLTALHTCD 238

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568944148 208 EVSIYGF---WPFSVnmqgdpishHYYDN----VLPFSGYHAMPEEfLQLW-YLHKIGALR 260
Cdd:cd23964  239 QVSVYGFgydPRFSL---------HYYDKtfvkFTVFYANHDFTNE-RKLWrKLHEEGIIN 289
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 56-261 1.55e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 80.57  E-value: 1.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  56 KCAVVGNGGILKMSGCGRQIDEANFVMRCNlPPLSSEYTRDVGSKTQLVTANPSIIRQRFEN-----------LLWSRKK 124
Cdd:cd23974   86 RCAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTLMNSLRAyagvgfngppqSKETRYI 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 125 FVDNmkiYNHSYIYMPAFSMKT----GTEPSLR-VYYTLKDVGANQTVLFaNPNFLRNI-GKFWKSRGIHAK-----RLS 193
Cdd:cd23974  165 FLPD---HDRDYLLVKAALTHTpidrGRDKSKRpSKYFGKDVTAEKFKIY-HPDFIRYLrNRFLWSPILNTKqrdiyRPS 240

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568944148 194 TGLFLVSAALGLCEEVSIYGFwpfsvnMQGD--PISHHYYDNV---LPFSGYHAMPEEfLQLWY-LHKIGALRM 261
Cdd:cd23974  241 TGAVMLLAALHTCDQVSAYGF------MTPDygKYSDHYYDKTyhkVVFYANHDLRLE-MQLWQkLHKAGLIKL 307
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 56-261 1.15e-16

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 77.71  E-value: 1.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  56 KCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANPsiirQRFENLLWSRKKFVDNMKIYNHS 135
Cdd:cd23966   79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKG-FEKDVGSKTTHHFMYP----ESAVDLDPGVHLVLVPFKVLDLQ 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 136 YIyMPAFSMKTGTepslRVYYTLKD-VGANQT-VLFANPNFLRNIGKFWKSRgiHAKRLSTGLFLVSAALGLCEEVSIYG 213
Cdd:cd23966  154 WL-ISALTTGEIT----RTYTPVKRfIKADKDkVLVINPAFIKYVHDNWTEH--HGRYPSTGFLALIFALHICDEVSVFG 226

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 214 F-------WpfsvnmqgdpisHHYYDNVLPFS-----GYHAMPEEFLQLWYLHKIGALRM 261
Cdd:cd23966  227 FgadskgnW------------HHYWEKNRSAGafrktGVHDADFESDIIKKLAKEGKIRV 274
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 55-233 3.79e-15

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 73.38  E-value: 3.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  55 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLVTANPSIIRQRFEN--LLWSRKKFVDNMKIY 132
Cdd:cd23980   82 RRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADVGSKTTHHFVYPESFRELAQNvsMILVPFKTLDLEWVI 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 133 --------NHSYIYMPAfsmktgtepSLRVyytlkdvgANQTVLFANPNFLRNIGKFWKSRgiHAKRLSTGLFLVSAALG 204
Cdd:cd23980  161 satttgtiSHTYVPVPR---------KIKV--------KKEKILIYHPAFIKYVFDRWLQG--HGRYPSTGILSVIFSLH 221

                        170       180
                 ....*....|....*....|....*....
gi 568944148 205 LCEEVSIYGfwpFSVNMQGDpiSHHYYDN 233
Cdd:cd23980  222 VCDEVDLYG---FGADSKGN--WHHYWEN 245
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 37-261 1.98e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 71.78  E-value: 1.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  37 DNSTYSLFPqatPFQLPLK--KCAVVGNGGILKMSGCGRQIDEANFVMRCNlPPLSSEYTRDVGSKTQLV-----TANPS 109
Cdd:cd23972   66 DSANAKLFF---PRDTPGKciRCAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFYgftvnTMKNS 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 110 IIrqRFENLLWSRKKFVDNMKiynhsYIYMPAfsmktgtepSLRVYYTLK------------DVGANQTVLFA------- 170
Cdd:cd23972  142 LI--SYWNLGFTRTPQGQDLQ-----YIFIPS---------DIRDYVMLRsailgvpvpeglDKGDRPHKYFGpeasakk 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 171 ----NPNFLRNI-GKFWKSRGI-----HAKRLSTGLFLVSAALGLCEEVSIYGFwpfsVNMQGDPISHHYYDNV---LPF 237
Cdd:cd23972  206 fkllHPDFISYLtDRFLKSKLLnthygHLYMPSTGALMLLTALHTCDQVSAYGF----ITSNYWKFSDHYYERKkkpLVF 281

                        250       260
                 ....*....|....*....|....*
gi 568944148 238 SGYHAMPEEfLQLW-YLHKIGALRM 261
Cdd:cd23972  282 YANHDMLLE-AALWrRLHKAGILQL 305
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 53-256 2.65e-14

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 69.63  E-value: 2.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  53 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANP-SIIRQRFENllwsrkkfvdnmkI 131
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKG-YEKDVGSKTTFRMFYPeSAFRDPEEY-------------D 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 132 YNHSYIYMPAFSMK--------TGTEPSLRVYYTLK-----DVGANQTVLFaNPNFLR----NIGKFWKSRGIHAKRLST 194
Cdd:cd23967   67 SDWLLVLVPFKSMDllwlqaviKGKKPNGKGGFWKKiatsvPKPPKKIRIL-NPYILQeaafDLIGLPMNGKQGKNVPTT 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568944148 195 GLFLVSAALGLCEEVSIYGFwPFSVNMQGDPIshHYYDNVL----PFSGYHAMPEEFLqlwYLHKI 256
Cdd:cd23967  146 GIIAIVMALHYCDEVDIAGF-GYDPSDPNAPL--HYYDSLTmkaiKRSWTHNVTKEKK---YLKKL 205
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 55-233 7.67e-14

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 69.90  E-value: 7.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  55 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKT----------QLVTANPSIIRQRFE--NLLWsr 122
Cdd:cd23979   81 RRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVGSRTthhfmypesaKNLPANVSFVLVPFKtlDLLW-- 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 123 kkFVDNMKIYNHSYIYMPafsmktgTEPSLRVyytlkdvgANQTVLFANPNFLRNIGKFWKSRgiHAKRLSTGLFLVSAA 202
Cdd:cd23979  158 --ITSALSTGQIRFTYAP-------VKQFLRV--------DKDKVQIYNPAFFKYIHDRWTEH--HGRYPSTGMLVLFFA 218

                        170       180       190
                 ....*....|....*....|....*....|.
gi 568944148 203 LGLCEEVSIYGfwpFSVNMQGDpiSHHYYDN 233
Cdd:cd23979  219 LHVCDEVNVYG---FGADSRGN--WHHYWEN 244
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 56-261 4.11e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 67.85  E-value: 4.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  56 KCAVVGNGGILKMSGCGRQIDEANFVMRCNlPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLlwsRKKFVDNMKIYNH- 134
Cdd:cd23973   85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVN-GAVIKGYEEDVGTRTSFYVHTAHSITSSLMIL---QKRGFKNIPQDKDi 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 135 SYIYMPAfsmktgtepSLRVYYTLKDVGANQTV-----------------------LFANPNFLRNI-GKFWKSRGIHAK 190
Cdd:cd23973  161 KYILFPE---------GPRDYQWLEALLKNKTIpsgayygrrprsyfsgdftedkyLVLHPDFLRYVkNRFLRSKTLKGK 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 191 -----RLSTGLFLVSAALGLCEEVSIYGFwpfsvnMQGD--PISHHYYDNV---LPFSGYHAMPEEfLQLW-YLHKIGAL 259
Cdd:cd23973  232 ywaiyRPTTGAFLLLTALHLCDTVSAYGF------ITEDyrKYPDHYYDKKktkLVFYINHDFRLE-KKLWkRLHDEKII 304


                 ..
gi 568944148 260 RM 261
Cdd:cd23973  305 KL 306
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 49-236 6.20e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 66.82  E-value: 6.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  49 PFQLPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQL-VTANPS---IIRQRFENLLWSRKK 124
Cdd:cd23976   10 PLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLrVIAHSSiqrILRNRNELLNVSQGT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 125 FV------DNMK------IYNHsyiympaFSMKTGTEPSLRVYYTLKdvganQTVLFANPNFLRNIGKfwkSRGIHAKRL 192
Cdd:cd23976   89 VFifwgpsNYMRrdgkglVYNN-------LQLMNQILPKLKVYTITR-----HKMLQFDELFKRETGK---DRKISNTWL 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 568944148 193 STGLFLVSAALGLCEEVSIYGFWP--FSVNMQGDPISHHYYDNVLP 236
Cdd:cd23976  154 STGWFTMIIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPSGP 199
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 41-246 2.53e-12

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 65.37  E-value: 2.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  41 YSLFPQATPFQLPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsSEYTRDVGSKT-------QLVTAN-----P 108
Cdd:cd23968   32 YPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPT-KGFEKDVGSKTtlrlinsQILSKPefnflT 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 109 SIIRQRFENLLWSRKKFVDNMKI--YNHSYIYMPAFSMKTGTEPSLRVYytlkdvganqtvlFANPNFLRNIgkfWK--- 183
Cdd:cd23968  111 DPLYRNVTLLVWDPSSYNVNLEKwyKKPDFDFFPNYIKYRRRHPEEPFY-------------LIDPRFLWRL---WDilq 174

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 184 ---SRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPfsvNMQGDPIShHYYDNVL----PFSGYHAMPEE 246
Cdd:cd23968  175 eytPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVP---SVRQTDRC-HYYDVEKdlacTLGAWHPLAAE 240
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 55-232 1.29e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 62.57  E-value: 1.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  55 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLV----TANPSIIRQR---FEN------LLWS 121
Cdd:cd23977    2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLRvvshTSVPLLLRNQgyfFQQsrdtkyVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 122 RKKFVDNMKiynhSYIYMPAFSMKTGTEPSLRVYYTLKDVGANQTVLFANPNflrnigkfWKSRGIHAKRLSTGLFLVSA 201
Cdd:cd23977   81 PERNMDRDG----GGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNET--------GKNRMKSGSFLSTGWFTMIL 148

                        170       180       190
                 ....*....|....*....|....*....|...
gi 568944148 202 ALGLCEEVSIYGFWPFSV--NMQGDPISHHYYD 232
Cdd:cd23977  149 ALELCEEILVYGMVSDSYcrNKNHSSVPYHYYE 181
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 53-235 3.14e-11

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 61.22  E-value: 3.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  53 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLsSEYTRDVGSKTQL-------VTANPSIIRQRFENLLWSRKKF 125
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPV-RGFEKDVGSKTTIrlfypesAQFDPGIENDPDTLLVLVPFKP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 126 VDNMKIYNhsyiympafsMKTGTEPSLRVYYT----LKDVGANQT-VLfaNPNFLRNIG-KFWKSRGIHAK--RLSTGLF 197
Cdd:cd23982   80 LDFYWLYE----------ILSNEKRVRKGFWKqpprIWDANPKQIrIL--NPYYTYVAAtKLLQVPGQRKKkqKPTTGLL 147

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 568944148 198 LVSAALGLCEEVSIYGF-WPFSVNmQGDPIshHYYDNVL 235
Cdd:cd23982  148 AITLALHLCDEVHIAGFgYPDNGN-SNQPI--HYYNQIT 183
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 55-232 3.85e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 61.10  E-value: 3.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  55 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQL-VTANPSIIRQRFENLLWSRKKFVDNMKIyn 133
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRG-YEKDVGRRTTIrVVSHSSLPRLLRNAILLLAGTRAPTVVV-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 134 hsyIYMPAFSMKTGTEPSLRV------------YYTLKDVGanqtVLFANPNFLRNIGkfwKSRGIHAKRLSTGLFLVSA 201
Cdd:cd23965   79 ---FWGPETKMNKDGAGKYNLlrslskkypdveFYSLTPEK----MDYADELFEKETG---KSRIKSGTWLSTGWFTMLL 148

                        170       180       190
                 ....*....|....*....|....*....|...
gi 568944148 202 ALGLCEEVSIYGFWP--FSVNMQGDPISHHYYD 232
Cdd:cd23965  149 ALDVCDEIKVYGMVPenYCREHPNSKVPYHYYE 181
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 53-253 1.82e-10

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 58.99  E-value: 1.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  53 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANP-SIIRQ---------------RFE 116
Cdd:cd23984    1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIG-YENDVGKRTTFRLCYPeSIFSDpshydpnttvvlipfKPH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 117 NLLWSrkkfvdnMKIYNHSYIYMPAFSMKtgtePSLRVYYTLkdvgaNQTVLFaNPNFLR----NIGKFWKSRGIHAKRL 192
Cdd:cd23984   80 DLRWL-------LDLLMGKKVSAKGFWKK----PALNLIYKP-----NQIRIL-NPFILRiaayELLHFPKRFPKEKKPK 142

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568944148 193 --STGLFLVSAALGLCEEVSIYGF-WPFSvnmqgDPISH-HYYDN----VLPFSGYHAMPEEFLQLWYL 253
Cdd:cd23984  143 hpTTGIIAITLALHICNEVHIAGFkYDFS-----NLNSTlHYYGNetmsVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 53-234 1.01e-09

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 57.06  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  53 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANP-----SIIRQRFENL--------- 118
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQG-YSQDVGNKTTIRMTYPegapkSEQEYDPTSLfvavlfksv 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 119 ---------------LWSRKKF-----------VDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKDVganqtvlfanP 172
Cdd:cd23983   80 dfawlkamvkkeplsFWSRLFFwkevadsiplkPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNV----------P 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568944148 173 nflrnigkfwksrgihakrlSTGLFLVSAALGLCEEVSIYGFwPFSVNMQGDPIshHYYDNV 234
Cdd:cd23983  150 --------------------TLGVTAVVLATHLCDEVSLAGF-GYDLSQPHAPL--HYYDSV 188
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 55-234 1.26e-09

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 56.85  E-value: 1.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  55 KKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQLVTANPSIIRQRFEN-----------LLWSRK 123
Cdd:cd23981    3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKG-FEKDVGSKTTLRITYPEGAIQKPEQyekdslfvlagFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 124 KFVDNMkiynhsyIYMPAFSMKTGTEPSLRVYYTlkdvGANQTVLFANPNFLRN-----IGKFWKSRGIHAKRLST-GLF 197
Cdd:cd23981   82 KWLKYI-------VYKEKVSASDGFWKSVATRVP----REPHEIRILNPYFIQEaafsfIGLPFNNGLMGRGNIPTlGSV 150

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 568944148 198 LVSAALGLCEEVSIYGFwPFSVNMQGDPIshHYYDNV 234
Cdd:cd23981  151 AITMALHNCDEVAVAGF-GYDMNTPNAPL--HYYETI 184
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 53-105 3.09e-09

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 56.25  E-value: 3.09e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  53 PLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKT-------QLVT 105
Cdd:cd23985   44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAG-FQQDVGTKTtirlinsQLVT 102
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 54-248 3.75e-09

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 56.00  E-value: 3.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  54 LKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQLVTANPSII---RQRFEN---------LLWS 121
Cdd:cd23986   49 FRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILtnpNHHFIDsslykdvilVAWD 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 122 RKKFVDNMKIYNHSyiymPAFSMKTgtePSLRvyYTLKDvgANQTVLFANPNFlrnIGKFWK------SRGIHAKRLSTG 195
Cdd:cd23986  128 PAPYSANLHKWYKK----PDYNLFT---PYVQ--YRKRN--PNQPFYILHPKF---IWQLWDiiqentQEKIQPNPPSSG 193

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568944148 196 LFLVSAALGLCEEVSIYGFWPfSVNmQGDPISHH--YYDNVLPFSGYHAMPEEFL 248
Cdd:cd23986  194 FIGILIMMSMCREVHVYEYIP-SVR-QTDLCHYHerYYDAACTLGAYHPLLYEKL 246
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 56-232 4.23e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 55.63  E-value: 4.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  56 KCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSeYTRDVGSKTQL-VTANPSIIRqrfenLLWSRKKFVDnmKIYNH 134
Cdd:cd23978    3 QCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTG-YEKDVGNKTTLrVVAHSSVYR-----VLRRPQEFLN--RTPET 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 135 SYIYM-PAFSMKTGTEPSL-RVYYTLKDVGANQTVLFANPNFLRNIGKFW-----KSRGIHAKRLSTGLFLVSAALGLCE 207
Cdd:cd23978   75 TLIFWgPPNKMQKDGKSNLfRIIQRASMTFPNMSAFVVSPRRMRQFDDLFrgetgRDRKKSHSWLSTGWFTMVIAVELCD 154

                        170       180
                 ....*....|....*....|....*...
gi 568944148 208 EVSIYGFWPF---SVNMQGDPISHHYYD 232
Cdd:cd23978  155 NVHVYGMVPPnycSKRPTPKKMPYHYYE 182
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 57-213 1.80e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 41.84  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148  57 CAVVGNGGILKMSGCGRQIDEANFVMRCNLPPlSSEYTRDVGSKTQ----------LVTANPSIIRQRFENLLWSRKKFV 126
Cdd:cd23975    4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAP-TKGYEEDVGKRTTirvvshtsvpLLLKNPDYFFKETNETIYVIWGPF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568944148 127 DNMKIYNHSYIYmPAFSMKTGTEPSLRVYYTlkdvgANQTVLFANPNFLRNIGkfwKSRGIHAKRLSTGLFLVSAALGLC 206
Cdd:cd23975   83 RNMRKDGKGIVY-NMLKKAVESYPQAKIYVT-----TEKRMSYCDTVFKKETG---KDRVQSGSYLSTGWFTLILAMDAC 153


                 ....*..
gi 568944148 207 EEVSIYG 213
Cdd:cd23975  154 YGIHVYG 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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