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Conserved domains on  [gi|568950405|ref|XP_006507785|]
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ataxin-2-like protein isoform X3 [Mus musculus]

Protein Classification

SM-ATX and LsmAD domain-containing protein( domain architecture ID 13860551)

SM-ATX and LsmAD domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 121-194 3.34e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 82.99  E-value: 3.34e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568950405   121 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVLLVHFR 194
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 262-324 1.57e-17

LsmAD domain; This domain is found associated with Lsm domain.


:

Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.57e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568950405   262 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 324
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 755-974 1.05e-10

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 65.83  E-value: 1.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   755 PPQRSDQHQPASAPPMMQAAAAAAGPPLVAATPYSSyiPYNPQQFPGQPAMMQPMA--------------HYPSQPVFAP 820
Cdd:pfam09770  107 PAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRT--GYEKYKEPEPIPDLQVDAslwgvapkkaaapaPAPQPAAQPA 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   821 MLQSNPRMLTS--------------------GSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSYPHHATQL--HGHQPQ 878
Cdd:pfam09770  185 SLPAPSRKMMSleeveaamraqakkpaqqpaPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVT 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   879 PATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPqssfPQPAavyaiHPHQQL 958
Cdd:pfam09770  265 ILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQ----PAPA-----HQAHRQ 335

                          250
                   ....*....|....*.
gi 568950405   959 PHGFTNMAHVTQAHVQ 974
Cdd:pfam09770  336 QGSFGRQAPIITHPQQ 351
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 401-946 4.34e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 4.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  401 GGPSRMSPKAQRPLRGAKTL--SSPSNRPSGEA--------SVPPTSAAlPFLPVGRMYPPRSPKSAAPAPVSASCPEPP 470
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPDRSVppPRPAPRPSEPAvtsrarrpDAPPQSAR-PRAPVDDRGDPRGPAPPSPLPPDTHAPDPP 2627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  471 I--GSAVASSASIPVTSSVVDPGAGSISPASPKLSLtptdvkelptkePSRnleAQELARIAGKVPGLQNEQKRfqleel 548
Cdd:PHA03247 2628 PpsPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSR------------PRR---ARRLGRAAQASSPPQRPRRR------ 2686

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  549 rkfgaqfKLQPSSSPETGL-DPFPsrilkeeakgkekevdglltsdPMGSPVSSktesildkedkvPMAGVGGTEGPeql 627
Cdd:PHA03247 2687 -------AARPTVGSLTSLaDPPP----------------------PPPTPEPA------------PHALVSATPLP--- 2722

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  628 PAPCPSQTGSPPVGLikgdekeeGPVTEQVKKSTLNPNAKEFNPTKPLlsvnksTSTPTSPGPrthstPSIPVlTAGQSG 707
Cdd:PHA03247 2723 PGPAAARQASPALPA--------APAPPAVPAGPATPGGPARPARPPT------TAGPPAPAP-----PAAPA-AGPPRR 2782

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  708 LYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPmmqaaaaaagpplvaatP 787
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG-----------------P 2845

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  788 YSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLTSGSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSY 865
Cdd:PHA03247 2846 PPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQ 2922

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  866 PHHATqlhghQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLP-PGPSAQSPQSSFP 944
Cdd:PHA03247 2923 PPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqPAPSREAPASSTP 2994


                  ..
gi 568950405  945 QP 946
Cdd:PHA03247 2995 PL 2996
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 121-194 3.34e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 82.99  E-value: 3.34e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568950405   121 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVLLVHFR 194
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 262-324 1.57e-17

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.57e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568950405   262 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 324
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 755-974 1.05e-10

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 65.83  E-value: 1.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   755 PPQRSDQHQPASAPPMMQAAAAAAGPPLVAATPYSSyiPYNPQQFPGQPAMMQPMA--------------HYPSQPVFAP 820
Cdd:pfam09770  107 PAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRT--GYEKYKEPEPIPDLQVDAslwgvapkkaaapaPAPQPAAQPA 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   821 MLQSNPRMLTS--------------------GSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSYPHHATQL--HGHQPQ 878
Cdd:pfam09770  185 SLPAPSRKMMSleeveaamraqakkpaqqpaPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVT 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   879 PATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPqssfPQPAavyaiHPHQQL 958
Cdd:pfam09770  265 ILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQ----PAPA-----HQAHRQ 335

                          250
                   ....*....|....*.
gi 568950405   959 PHGFTNMAHVTQAHVQ 974
Cdd:pfam09770  336 QGSFGRQAPIITHPQQ 351
PHA03247 PHA03247
large tegument protein UL36; Provisional
 401-946 4.34e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 4.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  401 GGPSRMSPKAQRPLRGAKTL--SSPSNRPSGEA--------SVPPTSAAlPFLPVGRMYPPRSPKSAAPAPVSASCPEPP 470
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPDRSVppPRPAPRPSEPAvtsrarrpDAPPQSAR-PRAPVDDRGDPRGPAPPSPLPPDTHAPDPP 2627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  471 I--GSAVASSASIPVTSSVVDPGAGSISPASPKLSLtptdvkelptkePSRnleAQELARIAGKVPGLQNEQKRfqleel 548
Cdd:PHA03247 2628 PpsPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSR------------PRR---ARRLGRAAQASSPPQRPRRR------ 2686

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  549 rkfgaqfKLQPSSSPETGL-DPFPsrilkeeakgkekevdglltsdPMGSPVSSktesildkedkvPMAGVGGTEGPeql 627
Cdd:PHA03247 2687 -------AARPTVGSLTSLaDPPP----------------------PPPTPEPA------------PHALVSATPLP--- 2722

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  628 PAPCPSQTGSPPVGLikgdekeeGPVTEQVKKSTLNPNAKEFNPTKPLlsvnksTSTPTSPGPrthstPSIPVlTAGQSG 707
Cdd:PHA03247 2723 PGPAAARQASPALPA--------APAPPAVPAGPATPGGPARPARPPT------TAGPPAPAP-----PAAPA-AGPPRR 2782

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  708 LYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPmmqaaaaaagpplvaatP 787
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG-----------------P 2845

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  788 YSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLTSGSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSY 865
Cdd:PHA03247 2846 PPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQ 2922

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  866 PHHATqlhghQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLP-PGPSAQSPQSSFP 944
Cdd:PHA03247 2923 PPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqPAPSREAPASSTP 2994


                  ..
gi 568950405  945 QP 946
Cdd:PHA03247 2995 PL 2996
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
874-949 1.42e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 45.92  E-value: 1.42e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568950405  874 GHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAphlgSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAV 949
Cdd:PRK14971  389 APQPSAAAAASPSPSQSSAAAQPSAPQSATQP----AGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPV 460
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 121-194 3.34e-19

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 82.99  E-value: 3.34e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568950405   121 MLHFLTAVVGSTCDVKVKNGTTYEGIFKTLS--SKFELAVDAVHRKASE--PAGGPRREDIVDTMVFKPSDVLLVHFR 194
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASleKDFGVVLKMARRIKKSngSGLNPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 262-324 1.57e-17

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 77.61  E-value: 1.57e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568950405   262 YGVKTTYDSSLssYTVPLEKdNSEEFRQRELRAAQLAREIESSPQYRLRIAMEN-----DDGRTEEEK 324
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERgldvdDSGLDEEDK 65
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 755-974 1.05e-10

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 65.83  E-value: 1.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   755 PPQRSDQHQPASAPPMMQAAAAAAGPPLVAATPYSSyiPYNPQQFPGQPAMMQPMA--------------HYPSQPVFAP 820
Cdd:pfam09770  107 PAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRT--GYEKYKEPEPIPDLQVDAslwgvapkkaaapaPAPQPAAQPA 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   821 MLQSNPRMLTS--------------------GSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSYPHHATQL--HGHQPQ 878
Cdd:pfam09770  185 SLPAPSRKMMSleeveaamraqakkpaqqpaPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHpgQGHPVT 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   879 PATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPqssfPQPAavyaiHPHQQL 958
Cdd:pfam09770  265 ILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQ----PAPA-----HQAHRQ 335

                          250
                   ....*....|....*.
gi 568950405   959 PHGFTNMAHVTQAHVQ 974
Cdd:pfam09770  336 QGSFGRQAPIITHPQQ 351
PHA03247 PHA03247
large tegument protein UL36; Provisional
 401-946 4.34e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 4.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  401 GGPSRMSPKAQRPLRGAKTL--SSPSNRPSGEA--------SVPPTSAAlPFLPVGRMYPPRSPKSAAPAPVSASCPEPP 470
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPDRSVppPRPAPRPSEPAvtsrarrpDAPPQSAR-PRAPVDDRGDPRGPAPPSPLPPDTHAPDPP 2627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  471 I--GSAVASSASIPVTSSVVDPGAGSISPASPKLSLtptdvkelptkePSRnleAQELARIAGKVPGLQNEQKRfqleel 548
Cdd:PHA03247 2628 PpsPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSR------------PRR---ARRLGRAAQASSPPQRPRRR------ 2686

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  549 rkfgaqfKLQPSSSPETGL-DPFPsrilkeeakgkekevdglltsdPMGSPVSSktesildkedkvPMAGVGGTEGPeql 627
Cdd:PHA03247 2687 -------AARPTVGSLTSLaDPPP----------------------PPPTPEPA------------PHALVSATPLP--- 2722

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  628 PAPCPSQTGSPPVGLikgdekeeGPVTEQVKKSTLNPNAKEFNPTKPLlsvnksTSTPTSPGPrthstPSIPVlTAGQSG 707
Cdd:PHA03247 2723 PGPAAARQASPALPA--------APAPPAVPAGPATPGGPARPARPPT------TAGPPAPAP-----PAAPA-AGPPRR 2782

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  708 LYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPmmqaaaaaagpplvaatP 787
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG-----------------P 2845

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  788 YSSYIPYNPQQFPGQPAMMQPMahyPSQPVFAPMLQSNP--RMLTSGSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSY 865
Cdd:PHA03247 2846 PPPSLPLGGSVAPGGDVRRRPP---SRSPAAKPAAPARPpvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQ 2922

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  866 PHHATqlhghQPQPATTPtgsQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLP-PGPSAQSPQSSFP 944
Cdd:PHA03247 2923 PPPPP-----QPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPqPAPSREAPASSTP 2994


                  ..
gi 568950405  945 QP 946
Cdd:PHA03247 2995 PL 2996
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 795-1033 1.81e-06

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 52.35  E-value: 1.81e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   795 NPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSG----SHPQAI----VSSS------TPQYPAAEQPTPQALYAT 860
Cdd:pfam09770  106 QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGyekyKEPEPIpdlqVDASlwgvapKKAAAPAPAPQPAAQPAS 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   861 VHQSYPHHAT------QLHGHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGP 934
Cdd:pfam09770  186 LPAPSRKMMSleeveaAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTI 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   935 SaQSPQSSFPQPAAVYA-IHPHQQLPHGFTNMAHVTQAHVQTGVtaappphpgaphppQVMLLHPPQGHGGPPQGAVPPS 1013
Cdd:pfam09770  266 L-QRPQSPQPDPAQPSIqPQAQQFHQQPPPVPVQPTQILQNPNR--------------LSAARVGYPQNPQPGVQPAPAH 330

                          250       260
                   ....*....|....*....|
gi 568950405  1014 GVPALSASTPSPYPYIGHPQ 1033
Cdd:pfam09770  331 QAHRQQGSFGRQAPIITHPQ 350
PHA03247 PHA03247
large tegument protein UL36; Provisional
 338-733 3.50e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  338 PSLVSREGKYIPLPQRVRegPRGGVRCSSSRGGRPGLSSLPPrGPHHLDNSSPGPGSEARGINGGPSRMSPKAQRPLRG- 416
Cdd:PHA03247 2580 PAVTSRARRPDAPPQSAR--PRAPVDDRGDPRGPAPPSPLPP-DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDp 2656

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  417 ----------------AKTLSSPSNRPSGEASVPP----TSAALPFLPVGRMYP------PRSPKSAAPAPVSASCPEPP 470
Cdd:PHA03247 2657 apgrvsrprrarrlgrAAQASSPPQRPRRRAARPTvgslTSLADPPPPPPTPEPaphalvSATPLPPGPAAARQASPALP 2736

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  471 IGSAVASSASIPVTSSVVDPGAGSISPASPKLSLTPTDvkelPTKEPSRNLEAQELARIAGKVPGLQNEQKRFQLEELRK 550
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA----PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL 2812

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  551 fGAQFKLQPSSSPETGLDPFPSrilkeeakgkekevdGLLTSDPMGSPVSSKTESIldkEDKVPMAGVGGTEGPEQLPAP 630
Cdd:PHA03247 2813 -APAAALPPAASPAGPLPPPTS---------------AQPTAPPPPPGPPPPSLPL---GGSVAPGGDVRRRPPSRSPAA 2873

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  631 CPSQTGSPPVGLIKGDEKEEGPVTEQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVL----TAGQS 706
Cdd:PHA03247 2874 KPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLApttdPAGAG 2953

                         410       420       430
                  ....*....|....*....|....*....|.
gi 568950405  707 ----GLYSPQYISYIPQIHMGPAVQAPQMYP 733
Cdd:PHA03247 2954 epsgAVPQPWLGALVPGRVAVPRFRVPQPAP 2984
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 372-699 6.30e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.38  E-value: 6.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  372 PGLSSLPPRGPHHlDNSSPGPGSEARGINGGPSRMSPKAQRPLRGAKtlsSPSNRPSGEASVPPTSAALPFLPVGRMYP- 450
Cdd:PTZ00449  514 PEASGLPPKAPGD-KEGEEGEHEDSKESDEPKEGGKPGETKEGEVGK---KPGPAKEHKPSKIPTLSKKPEFPKDPKHPk 589

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  451 -PRSPKSAApAPVSASCPEPPIGSAVASSASIPVTSSVVDPGAGSISPASPKLSLT---PTDVKELPTKEPSRnleaqel 526
Cdd:PTZ00449  590 dPEEPKKPK-RPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSperPEGPKIIKSPKPPK------- 661

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  527 ariAGKVPglqneqkrFQLEELRKFGAQFKLQPSSSPETGLDPFPSRILKEEAKGKEKEVDGLLTSDPMG-SPVSSKTES 605
Cdd:PTZ00449  662 ---SPKPP--------FDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPlPPKLPRDEE 730

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  606 ILDKEDKVPMAgvggtegpeqlPAPCPSQTGSPPVGL------IKGDEKEEGPVTEQVKKSTLNPNAKEfnPTKPLLSVN 679
Cdd:PTZ00449  731 FPFEPIGDPDA-----------EQPDDIEFFTPPEEErtffheTPADTPLPDILAEEFKEEDIHAETGE--PDEAMKRPD 797

                         330       340
                  ....*....|....*....|.
gi 568950405  680 KSTS-TPTSPGprTHstPSIP 699
Cdd:PTZ00449  798 SPSEhEDKPPG--DH--PSLP 814
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
874-949 1.42e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 45.92  E-value: 1.42e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568950405  874 GHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAphlgSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAV 949
Cdd:PRK14971  389 APQPSAAAAASPSPSQSSAAAQPSAPQSATQP----AGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPV 460
PRK10927 PRK10927
cell division protein FtsN;
845-948 3.12e-04

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 44.29  E-value: 3.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  845 QYPAAEQPTPQalyatvHQSYPHHATQLHGHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALT 924
Cdd:PRK10927  144 QTPEQRQQTLQ------RQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQPYQDLLQTPAHT 217

                          90       100
                  ....*....|....*....|....*
gi 568950405  925 GTPPSLP-PGPSAQSPQSsfPQPAA 948
Cdd:PRK10927  218 TAQSKPQqAAPVTRAADA--PKPTA 240
PHA03247 PHA03247
large tegument protein UL36; Provisional
 553-1079 3.19e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 3.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  553 AQFKLQPSSSPETGLDPFPSrilKEEAKGKEKEVDGLLTSDPMGSPVSSKTESILDKEDKVPMAGVGGTEG--PEQLPAP 630
Cdd:PHA03247 2486 ARFPFAAGAAPDPGGGGPPD---PDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPplPPAAPPA 2562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  631 CPSQTGSPPvglikgdEKEEGPVTEQVKKSTLNPNAKEfNPTKPLLSVNKSTSTPTSPGPrTHSTPSIPVLTAGQSGLYS 710
Cdd:PHA03247 2563 APDRSVPPP-------RPAPRPSEPAVTSRARRPDAPP-QSARPRAPVDDRGDPRGPAPP-SPLPPDTHAPDPPPPSPSP 2633

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  711 PQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQ-QGKYRGAKGSLPPQRSDQHQ---PASAPPMMQAAAAAAGPPLVAAT 786
Cdd:PHA03247 2634 AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRaRRLGRAAQASSPPQRPRRRAarpTVGSLTSLADPPPPPPTPEPAPH 2713

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  787 PYSSYIPYNP-QQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPAAeQPTPQALYATVhqsy 865
Cdd:PHA03247 2714 ALVSATPLPPgPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAA-GPPRRLTRPAV---- 2788

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  866 phhatqlhghqpQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQS------- 938
Cdd:PHA03247 2789 ------------ASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSlplggsv 2856

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  939 -----------PQSSFPQPAAVYAIhPHQQLPHGFTNMAHVTQAHVQTGVTAAPPPHPGAPHPPQVMLLHPPQGHGGPPQ 1007
Cdd:PHA03247 2857 apggdvrrrppSRSPAAKPAAPARP-PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP 2935

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568950405 1008 GAVPPSGVPALSASTPSPYPYIGHPqvcrvgrshSRRRQGLAPGSVLCfpPSSLSCDPAAPLPTASPALSDP 1079
Cdd:PHA03247 2936 PPRPQPPLAPTTDPAGAGEPSGAVP---------QPWLGALVPGRVAV--PRFRVPQPAPSREAPASSTPPL 2996
Herpes_TAF50 pfam03326
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 ...
 624-920 4.48e-04

Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.


Pssm-ID: 308764 [Multi-domain]  Cd Length: 568  Bit Score: 44.30  E-value: 4.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   624 PEQLPAPCPSQTGSPP----VGLIKGDEKEEGPVTEQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIP 699
Cdd:pfam03326  269 PQRLQAPGFSRSTSRPargqTAQYFLAAQQHGVVSLFPSTATLVPIAGSTGVTEVVSYGHNSTSPSSTPCPSTAVTEADH 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   700 VLTAGQSGLYSPQYISYipQIHMGPAVQAPQMYPYPvsnsvpgqqGKYRGAKGsLPPQRSDQHQPAsappmmqAAAAAAG 779
Cdd:pfam03326  349 QTEPEVPWIATAHQESD--QRPIGPGPEKPTFLPPV---------GGKQFFQG-LRDSRSTSFLTA-------PEATSAI 409

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   780 PPLVAATPYSSYIPYNPQQFPGQPammqpmahypsqpvfapmlqSNPRMLTSGSHPQAIVSSSTPQYPAAEQPTPQALYA 859
Cdd:pfam03326  410 SDVFQGTEVCQPKRIRALHPPGSP--------------------SANRPLPSSLAPTPTGPVHEPGSSLTPATVPQPLDA 469

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568950405   860 T--VHQSYPHHATQLHGHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHP 920
Cdd:pfam03326  470 ApvATPEASHELQPPDEETPQPLDEDQALCGQQDASHPPPRGQLDELTTTLESMTEDLNLDSP 532
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 797-954 5.51e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.31  E-value: 5.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  797 QQFPG-QPAMMQPMAHypSQPVFAPMlqsnPRMLTSGSHPQAIVSSSTPQYPAAEQPTPQALYATVHQSYPHHATQLHGH 875
Cdd:PRK10263  709 QRYSGeQPAGANPFSL--DDFEFSPM----KALLDDGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQ 782

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568950405  876 QPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQnlyhpgaltgtpPSLPPGPSAQSPQSSFPQPAAVYaIHP 954
Cdd:PRK10263  783 QPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQ------------PVAPQPQYQQPQQPVAPQPQDTL-LHP 848
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 845-1051 1.04e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.10  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   845 QYPAAEQPTPQALYATVHQSYPHHATQLHGHQPQPATT---------------------PTGSQPQSQHAAPSPVQHQAG 903
Cdd:pfam09770  105 QQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTgyekykepepipdlqvdaslwGVAPKKAAAPAPAPQPAAQPA 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   904 QAPHLG-------------SGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIHPHQQLPHGFTNMAHVTQ 970
Cdd:pfam09770  185 SLPAPSrkmmsleeveaamRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVT 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   971 AHVQTGVTAAPPPHPGAPHPPQVMLLHPPQGHGGPPQGAVPPSGVPALSASTPSPYPYIGHPQvcrvGRSHSRRRQGLAP 1050
Cdd:pfam09770  265 ILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPA----PAHQAHRQQGSFG 340


                   .
gi 568950405  1051 G 1051
Cdd:pfam09770  341 R 341
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 333-518 3.17e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.60  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  333 SGRESPSLVSREGKYIPLPQRVREGPRGGvRCSSSRGGRPglSSLP-----PRGP----HHLDNSSPGPGSEARGINGGP 403
Cdd:PTZ00449  531 EGEHEDSKESDEPKEGGKPGETKEGEVGK-KPGPAKEHKP--SKIPtlskkPEFPkdpkHPKDPEEPKKPKRPRSAQRPT 607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  404 SRMSPKAQRPLRGAKTLSSPSNRPSGEASVPPTSAALPFLPVGrmypPRSPKSAAPaPVSascPEPPIG----------- 472
Cdd:PTZ00449  608 RPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEG----PKIIKSPKP-PKS---PKPPFDpkfkekfyddy 679

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 568950405  473 SAVASSASIPVTSSVVDPGAGSISPAS-PKLSLTP-TDVKELPTKEPS 518
Cdd:PTZ00449  680 LDAAAKSKETKTTVVLDESFESILKETlPETPGTPfTTPRPLPPKLPR 727
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
413-555 4.63e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.91  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  413 PLRGAKTLSSPSNrpSGEASVPPTSAAlpflPVGRMYPPRS---PKSAAPAPVSASCPEPPIGSaVASSASIPVTSSVVD 489
Cdd:PRK14971  371 GGRGPKQHIKPVF--TQPAAAPQPSAA----AAASPSPSQSsaaAQPSAPQSATQPAGTPPTVS-VDPPAAVPVNPPSTA 443

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568950405  490 PGAGSISPASPKLSLTPTDV--KELPTKEPSRNLEAQELARIAGKVPGLQNEQkrFQLEELRKFGAQF 555
Cdd:PRK14971  444 PQAVRPAQFKEEKKIPVSKVssLGPSTLRPIQEKAEQATGNIKEAPTGTQKEI--FTEEDLQYYWQEF 509
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 793-1076 6.68e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 40.38  E-value: 6.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   793 PYNPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSHPqaIVSSSTPQYPAAEQPTPQALYATVHQSYPHHATQl 872
Cdd:pfam09606  168 SGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMGVPGMP--GPADAGAQMGQQAQANGGMNPQQMGGAPNQVAMQ- 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   873 hghqpQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGAltgTPPSLPPGPSAQSPQSSFPQPAavyai 952
Cdd:pfam09606  245 -----QQQPQQQGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPGQ---QPGAMPNVMSIGDQNNYQQQQT----- 311

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   953 HPHQQLPHGFTNMAHVTQAHVQTGvtaapPPHPGAPHPPQVMLLHPPQGHGGpPQGAVPPSGVPALSASTPSPYPyigHP 1032
Cdd:pfam09606  312 RQQQQQQGGNHPAAHQQQMNQSVG-----QGGQVVALGGLNHLETWNPGNFG-GLGANPMQRGQPGMMSSPSPVP---GQ 382

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 568950405  1033 QVCRVGRSHSRRRQGlAPGSVLCFPPSSLSCDPAAPLPTASPAL 1076
Cdd:pfam09606  383 QVRQVTPNQFMRQSP-QPSVPSPQGPGSQPPQSHPGGMIPSPAL 425
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
755-948 8.58e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 8.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  755 PPQRSDQHQPASAPPMMQAAAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSH 834
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  835 PQAIVSSSTP-------QYPAAEQPTPQALYATVHQSYPHHATQlhgHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPH 907
Cdd:PRK12323  445 GGAPAPAPAPaaapaaaARPAAAGPRPVAAAAAAAPARAAPAAA---PAPADDDPPPWEELPPEFASPAPAQPDAAPAGW 521

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 568950405  908 LGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAA 948
Cdd:PRK12323  522 VAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVA 562
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
387-527 8.73e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 8.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  387 NSSPGPGSEARGINGGPSRMSPKAQRPLRGAKTLSSPSNRPSGEASVPPTSA------ALPFLPVGRMYPPRSPKSA-AP 459
Cdd:PRK12323  371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAparrspAPEALAAARQASARGPGGApAP 450

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568950405  460 APVSASCPEPPIGSAVASSASIPVTSSVVDPGAGSISPASPKLSLTPTdVKELPTKEPSRNLEAQELA 527
Cdd:PRK12323  451 APAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPP-WEELPPEFASPAPAQPDAA 517
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 737-1077 9.69e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 9.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   737 SNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAAGPPLVAATPYSSYIPYNPQQFP-GQPAMMQPMAHYPSQ 815
Cdd:pfam03154  145 SPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPqGSPATSQPPNQTQST 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   816 PVFAPMLQSNPRMltsgsHPQAIVSSSTPQYPAAEQPTPQALYATVHQSYPHHatqlhghqpqpatTPTGSQPQSQHAAP 895
Cdd:pfam03154  225 AAPHTLIQQTPTL-----HPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLH-------------GQMPPMPHSLQTGP 286

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   896 SPVQHQAGQAPHLGSGQPQQNLYHPGALTG----------TPPSLPPGPSAQSPQSSFPQPAAVYAIH----PHQQLPHG 961
Cdd:pfam03154  287 SHMQHPVPPQPFPLTPQSSQSQVPPGPSPAapgqsqqrihTPPSQSQLQSQQPPREQPLPPAPLSMPHikppPTTPIPQL 366

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405   962 FTNMAHVTQAHVQT----GVTAAPPPHPGAPHPPQVMLLHPPQGHGGP----PQG---AVPPSGVPALSASTPSPYPYIG 1030
Cdd:pfam03154  367 PNPQSHKHPPHLSGpspfQMNSNLPPPPALKPLSSLSTHHPPSAHPPPlqlmPQSqqlPPPPAQPPVLTQSQSLPPPAAS 446

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 568950405  1031 HPQvcrVGRSHSRRRQGLAPGSVLCFPPSSLSCDPAAPLPTASPALS 1077
Cdd:pfam03154  447 HPP---TSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMP 490
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 392-558 9.99e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.70  E-value: 9.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  392 PGSEARGINGGPSRMSPKAQRPLRGAKTLSSPsnRPSGEASVPPTSAAlPFLPVGRMYPPRSPKSAAPAPVSASCPEPPI 471
Cdd:PRK14951  374 APAEKKTPARPEAAAPAAAPVAQAAAAPAPAA--APAAAASAPAAPPA-AAPPAPVAAPAAAAPAAAPAAAPAAVALAPA 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950405  472 GSAVASS--ASIPVTSSV---VDPGAGSISPASPKLSLTPTD--------VKELPTKEPSRNLeAQELAriagkvpgLQN 538
Cdd:PRK14951  451 PPAQAAPetVAIPVRVAPepaVASAAPAPAAAPAAARLTPTEegdvwhatVQQLAAAEAITAL-ARELA--------LQS 521

                         170       180
                  ....*....|....*....|....*....
gi 568950405  539 E---------QKRFQLEELRKFGAQFKLQ 558
Cdd:PRK14951  522 ElvardgdqwLLRVERESLNQPGARERLR 550
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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