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Conserved domains on  [gi|568951523|ref|XP_006508324|]
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uncharacterized protein LOC74466 isoform X1 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
12-449 6.12e-43

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17481:

Pssm-ID: 475125  Cd Length: 429  Bit Score: 156.72  E-value: 6.12e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523  12 VYSLITLGTEMLSSFFSFYYVKLFLEVYKISKSAFCQAQVILMIWNILTD-LSGY-----FHMSSQYDCCLSYRCSLLGA 85
Cdd:cd17481    2 AYGSLAFFLSILHNVFLLYYVDVFVSVYKIDKASFWIGETIFLIWNSLNDpLFGWlsdrkFLSSSSSGAHISSPAVVLKR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523  86 L--------LHAVAFLLPWFPWKHyresdwlIGLQLVASLCAFDSTHAWVQQAQWRLFAETSPRQESRLQLTRINQVASL 157
Cdd:cd17481   82 LralsingpLFALSFLAFWVPWAP-------PGLQFVVCLCLYDGFLTMVDLNHNALLADLAVSAEDRTRLNSYCSVFSA 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 158 VGSVSiLFCGLISHNMEILPNFQATSVAIAFLASLSFYsgmfnvrqfefkrnpeenvlseseqelaRTSVILlmrqilsq 237
Cdd:cd17481  155 IGSLS-VFLSYAVWDKENLGSFRIFCACLAIISAVGFF----------------------------LSSALL-------- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 238 rNFYLFLIMNFFQVFHLTIFSNFMMIFVDNLIpTEALSSSVRSIMYGAGFICPQCLVLLGQSWLKKYGYYKVILISFYLE 317
Cdd:cd17481  198 -NFLWFVVMNLVQVFHCHFNSNFFPLFLEHLL-GDHISPSTGSVLLGISFVAPHLNNLYFLSLCRRYGVYNVVRGLFLIK 275
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 318 GAAALVMLLLGQEHYYCLAVYLTVIMVIVHTSLCLFNLPVADMVEADLPKFNRQPPFSLMVAVISALFTRPAQSLAPML- 396
Cdd:cd17481  276 LGLSLAMLLAGPDLLWLLCLFIASNRVFTEGTCKLLNLVISDLVDEDYVLNHRKQAISALVFGTAALLSKPGQTLAPLIg 355
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568951523 397 -------------------ILSKLNQHEHGEANNRrllDLQDSMFNSVCVVSLGIATVQILTWSSFSVRNRR 449
Cdd:cd17481  356 twllcvqtgsdlfqtgaepGSIKQQQSSADEASTQ---TLRQGCFYLLVYVPIVCALIQLLAWSQFTLHGRR 424
 
Name Accession Description Interval E-value
MFS_MFSD13A cd17481
Major facilitator superfamily domain containing 13A; Human major facilitator superfamily ...
12-449 6.12e-43

Major facilitator superfamily domain containing 13A; Human major facilitator superfamily domain containing 13A (MFSD1A) protein is also called transmembrane protein 180. Its function is still unknown. MFSD13A belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement


Pssm-ID: 341034  Cd Length: 429  Bit Score: 156.72  E-value: 6.12e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523  12 VYSLITLGTEMLSSFFSFYYVKLFLEVYKISKSAFCQAQVILMIWNILTD-LSGY-----FHMSSQYDCCLSYRCSLLGA 85
Cdd:cd17481    2 AYGSLAFFLSILHNVFLLYYVDVFVSVYKIDKASFWIGETIFLIWNSLNDpLFGWlsdrkFLSSSSSGAHISSPAVVLKR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523  86 L--------LHAVAFLLPWFPWKHyresdwlIGLQLVASLCAFDSTHAWVQQAQWRLFAETSPRQESRLQLTRINQVASL 157
Cdd:cd17481   82 LralsingpLFALSFLAFWVPWAP-------PGLQFVVCLCLYDGFLTMVDLNHNALLADLAVSAEDRTRLNSYCSVFSA 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 158 VGSVSiLFCGLISHNMEILPNFQATSVAIAFLASLSFYsgmfnvrqfefkrnpeenvlseseqelaRTSVILlmrqilsq 237
Cdd:cd17481  155 IGSLS-VFLSYAVWDKENLGSFRIFCACLAIISAVGFF----------------------------LSSALL-------- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 238 rNFYLFLIMNFFQVFHLTIFSNFMMIFVDNLIpTEALSSSVRSIMYGAGFICPQCLVLLGQSWLKKYGYYKVILISFYLE 317
Cdd:cd17481  198 -NFLWFVVMNLVQVFHCHFNSNFFPLFLEHLL-GDHISPSTGSVLLGISFVAPHLNNLYFLSLCRRYGVYNVVRGLFLIK 275
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 318 GAAALVMLLLGQEHYYCLAVYLTVIMVIVHTSLCLFNLPVADMVEADLPKFNRQPPFSLMVAVISALFTRPAQSLAPML- 396
Cdd:cd17481  276 LGLSLAMLLAGPDLLWLLCLFIASNRVFTEGTCKLLNLVISDLVDEDYVLNHRKQAISALVFGTAALLSKPGQTLAPLIg 355
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568951523 397 -------------------ILSKLNQHEHGEANNRrllDLQDSMFNSVCVVSLGIATVQILTWSSFSVRNRR 449
Cdd:cd17481  356 twllcvqtgsdlfqtgaepGSIKQQQSSADEASTQ---TLRQGCFYLLVYVPIVCALIQLLAWSQFTLHGRR 424
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
8-398 1.98e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 68.78  E-value: 1.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523   8 SEVWVYSLITLGTEMLSSFFSFYYVKLFLEVYKISKSAFCQAQVILMIWNILTD-LSGYfhmssqydccLSYRCS----- 81
Cdd:COG2211   10 KEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDpLIGA----------LSDRTRtrwgr 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523  82 -----LLGALLHAVAFLLPWFPwkhYRESDWLIGLQLVASLCAFDSTHAWVQQAQWRLFAETSPRQESRLQLTRINQVAS 156
Cdd:COG2211   80 rrpwiLIGAIPLALSFVLLFTA---PDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 157 LVGSVSILFCGLI---SHNMEILPNFQATSVAIAFLASLSFYSGMFNVRqfefkrnpeENVLSESEqelaRTSVILLMRQ 233
Cdd:COG2211  157 GLGGLLASVLPPPlvaAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTK---------ERPVPEEE----KVSLKESLKA 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 234 ILSQRNFYLFLIMNFFQVFHLTIFSNFMMIFVDNLIpteALSSSVRSIMYGAGFICPQCLVLLGQSWLKKYGYYKVILIS 313
Cdd:COG2211  224 LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL---GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIG 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 314 FYLEGAAALVMLLLGQEHYYCLAVyLTVIMVIVHTSLCLFNLP-VADMVEADLPKFNRQPP---FSLMVAVISAlftrpA 389
Cdd:COG2211  301 LLLAALGLLLLFFLGPGNLWLLLV-LAALAGIGLGAILVLPWAmLADVVDYDEWKTGRRREglyFGIFTFAIKL-----G 374

                 ....*....
gi 568951523 390 QSLAPMLIL 398
Cdd:COG2211  375 QALAGALAG 383
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
13-364 8.33e-07

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 51.16  E-value: 8.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523   13 YSLITLGTEMLSSFFSFYYVKLFLEVYKISKSAFCQAQVILMIWNILTD-LSGYF--HMSSQYDCCLSYrcSLLGALLHA 89
Cdd:pfam13347   2 YGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDpIVGHIidRTRTRWGRRRPW--LLLSAIILA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523   90 VAFLLPWFPWKHYRESD--WLIglqlvASLCAFDSTHAWVQQAQWRLFAETSPRQESRLQLTRINQVASLVGSVSilfcG 167
Cdd:pfam13347  80 VSFILLFTPPELGRAPLfiWLL-----ATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLL----A 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523  168 LISHNMEILPNFQATSVAIAFLASLSFYSGMFN---VRQFEFKRNPEENVLSESEQELARTSVILLMRQILSQRNFYLFL 244
Cdd:pfam13347 151 AALAFPLVLILGGTGLERKGYRIFALIGAVLMLlgvIITAAGTKERVSMRSKEDTGQKEAGSLLDMLKEVFRNRAFLILL 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523  245 IMNFFQVFHLTIFSNFMMIFVDNLIPTEALSssvrSIMYGAGFIcPQCLVLLGQSWL-KKYGYYKVILISFYLEGAAALV 323
Cdd:pfam13347 231 ASFLLAALAMGVLNGLLLYYFRYVLGNGFAA----SAFPLVFTI-GALLGIPLWPPLaKRIGKKNTYILGALITIAGFAL 305
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 568951523  324 MLLLGQEHYYCLAVYLTVIMVIVHTSLCLFNLPVADMVEAD 364
Cdd:pfam13347 306 ALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYG 346
 
Name Accession Description Interval E-value
MFS_MFSD13A cd17481
Major facilitator superfamily domain containing 13A; Human major facilitator superfamily ...
12-449 6.12e-43

Major facilitator superfamily domain containing 13A; Human major facilitator superfamily domain containing 13A (MFSD1A) protein is also called transmembrane protein 180. Its function is still unknown. MFSD13A belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement


Pssm-ID: 341034  Cd Length: 429  Bit Score: 156.72  E-value: 6.12e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523  12 VYSLITLGTEMLSSFFSFYYVKLFLEVYKISKSAFCQAQVILMIWNILTD-LSGY-----FHMSSQYDCCLSYRCSLLGA 85
Cdd:cd17481    2 AYGSLAFFLSILHNVFLLYYVDVFVSVYKIDKASFWIGETIFLIWNSLNDpLFGWlsdrkFLSSSSSGAHISSPAVVLKR 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523  86 L--------LHAVAFLLPWFPWKHyresdwlIGLQLVASLCAFDSTHAWVQQAQWRLFAETSPRQESRLQLTRINQVASL 157
Cdd:cd17481   82 LralsingpLFALSFLAFWVPWAP-------PGLQFVVCLCLYDGFLTMVDLNHNALLADLAVSAEDRTRLNSYCSVFSA 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 158 VGSVSiLFCGLISHNMEILPNFQATSVAIAFLASLSFYsgmfnvrqfefkrnpeenvlseseqelaRTSVILlmrqilsq 237
Cdd:cd17481  155 IGSLS-VFLSYAVWDKENLGSFRIFCACLAIISAVGFF----------------------------LSSALL-------- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 238 rNFYLFLIMNFFQVFHLTIFSNFMMIFVDNLIpTEALSSSVRSIMYGAGFICPQCLVLLGQSWLKKYGYYKVILISFYLE 317
Cdd:cd17481  198 -NFLWFVVMNLVQVFHCHFNSNFFPLFLEHLL-GDHISPSTGSVLLGISFVAPHLNNLYFLSLCRRYGVYNVVRGLFLIK 275
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 318 GAAALVMLLLGQEHYYCLAVYLTVIMVIVHTSLCLFNLPVADMVEADLPKFNRQPPFSLMVAVISALFTRPAQSLAPML- 396
Cdd:cd17481  276 LGLSLAMLLAGPDLLWLLCLFIASNRVFTEGTCKLLNLVISDLVDEDYVLNHRKQAISALVFGTAALLSKPGQTLAPLIg 355
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568951523 397 -------------------ILSKLNQHEHGEANNRrllDLQDSMFNSVCVVSLGIATVQILTWSSFSVRNRR 449
Cdd:cd17481  356 twllcvqtgsdlfqtgaepGSIKQQQSSADEASTQ---TLRQGCFYLLVYVPIVCALIQLLAWSQFTLHGRR 424
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
8-398 1.98e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 68.78  E-value: 1.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523   8 SEVWVYSLITLGTEMLSSFFSFYYVKLFLEVYKISKSAFCQAQVILMIWNILTD-LSGYfhmssqydccLSYRCS----- 81
Cdd:COG2211   10 KEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDpLIGA----------LSDRTRtrwgr 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523  82 -----LLGALLHAVAFLLPWFPwkhYRESDWLIGLQLVASLCAFDSTHAWVQQAQWRLFAETSPRQESRLQLTRINQVAS 156
Cdd:COG2211   80 rrpwiLIGAIPLALSFVLLFTA---PDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFA 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 157 LVGSVSILFCGLI---SHNMEILPNFQATSVAIAFLASLSFYSGMFNVRqfefkrnpeENVLSESEqelaRTSVILLMRQ 233
Cdd:COG2211  157 GLGGLLASVLPPPlvaAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTK---------ERPVPEEE----KVSLKESLKA 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 234 ILSQRNFYLFLIMNFFQVFHLTIFSNFMMIFVDNLIpteALSSSVRSIMYGAGFICPQCLVLLGQSWLKKYGYYKVILIS 313
Cdd:COG2211  224 LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL---GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIG 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 314 FYLEGAAALVMLLLGQEHYYCLAVyLTVIMVIVHTSLCLFNLP-VADMVEADLPKFNRQPP---FSLMVAVISAlftrpA 389
Cdd:COG2211  301 LLLAALGLLLLFFLGPGNLWLLLV-LAALAGIGLGAILVLPWAmLADVVDYDEWKTGRRREglyFGIFTFAIKL-----G 374

                 ....*....
gi 568951523 390 QSLAPMLIL 398
Cdd:COG2211  375 QALAGALAG 383
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
13-364 8.33e-07

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 51.16  E-value: 8.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523   13 YSLITLGTEMLSSFFSFYYVKLFLEVYKISKSAFCQAQVILMIWNILTD-LSGYF--HMSSQYDCCLSYrcSLLGALLHA 89
Cdd:pfam13347   2 YGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDpIVGHIidRTRTRWGRRRPW--LLLSAIILA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523   90 VAFLLPWFPWKHYRESD--WLIglqlvASLCAFDSTHAWVQQAQWRLFAETSPRQESRLQLTRINQVASLVGSVSilfcG 167
Cdd:pfam13347  80 VSFILLFTPPELGRAPLfiWLL-----ATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLL----A 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523  168 LISHNMEILPNFQATSVAIAFLASLSFYSGMFN---VRQFEFKRNPEENVLSESEQELARTSVILLMRQILSQRNFYLFL 244
Cdd:pfam13347 151 AALAFPLVLILGGTGLERKGYRIFALIGAVLMLlgvIITAAGTKERVSMRSKEDTGQKEAGSLLDMLKEVFRNRAFLILL 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523  245 IMNFFQVFHLTIFSNFMMIFVDNLIPTEALSssvrSIMYGAGFIcPQCLVLLGQSWL-KKYGYYKVILISFYLEGAAALV 323
Cdd:pfam13347 231 ASFLLAALAMGVLNGLLLYYFRYVLGNGFAA----SAFPLVFTI-GALLGIPLWPPLaKRIGKKNTYILGALITIAGFAL 305
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 568951523  324 MLLLGQEHYYCLAVYLTVIMVIVHTSLCLFNLPVADMVEAD 364
Cdd:pfam13347 306 ALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYG 346
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
82-364 1.11e-05

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 47.60  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523  82 LLGALLHAVAFLLPWFPwkhYRESDWLIGLQLVASLCAFDSTHAWVQQAQWRLFAETSPRQESRLQLTRINQVASLVGSV 161
Cdd:cd17332   74 LWGAIPLALLFVLLFTT---PDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGL 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 162 SILFCGLI----SHNMEILPNFQATSVAIAFLASLSFYSGMFNVRqfefkrnpEENVLSESEQELARTSVILlmRQILSQ 237
Cdd:cd17332  151 LVTVLPPPlvayFGGGNASRGYFLTALIIGIIGIILLLICFFGTR--------ERVVPPEEEKSKLPLLKSL--KALLKN 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568951523 238 RNFYLFLIMNFFQVFHLTIFSNFMMIFVD-NLIPTEALSSSVRSIMYGAGFICPqclvllGQSWLKKYGYYKVILISFYL 316
Cdd:cd17332  221 RPFLILLLAYLLYFLAFNIVNTVLVYYFKyVLGGRAELVLLLLLILSGALLALL------PWPPLKKRFGKKKAFFIGLL 294
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 568951523 317 EGAAALVMLLLGQEHYYCLAVYLTVIMVIVHTSLCLFNLP-VADMVEAD 364
Cdd:cd17332  295 LAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAmLADVIDYG 343
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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