transcription factor IIIB 50 kDa subunit isoform X1 [Mus musculus]
Protein Classification
cyclin family protein( domain architecture ID 1750054)
cyclin family protein may associate with and activate its cognate cyclin-dependent kinase
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| CYCLIN_SF super family | cl40454 | Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ... |
1-28 | 6.64e-04 | ||
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box. The actual alignment was detected with superfamily member cd20555: Pssm-ID: 477360 [Multi-domain] Cd Length: 97 Bit Score: 38.03 E-value: 6.64e-04
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| Name | Accession | Description | Interval | E-value | ||
| CYCLIN_BRF2 | cd20555 | cyclin box found in B-related factor 2 (BRF-2) and similar proteins; BRF-2, also called ... |
1-28 | 6.64e-04 | ||
cyclin box found in B-related factor 2 (BRF-2) and similar proteins; BRF-2, also called transcription factor IIIB 50 kDa subunit (TFIIIB50), or BRFU, is a general activator of RNA polymerase (Pol) III transcription and is required for Pol III transcription of genes with promoter elements upstream of the initiation sites. It recruits Pol III to type III gene-external promoters, including the U6 spliceosomal RNA and selenocysteine tRNA genes. BRF-2 contains one cyclin box. The cyclin box fold is generally a protein binding domain, but binds DNA in BRF-2. Pssm-ID: 410258 [Multi-domain] Cd Length: 97 Bit Score: 38.03 E-value: 6.64e-04
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| Name | Accession | Description | Interval | E-value | ||
| CYCLIN_BRF2 | cd20555 | cyclin box found in B-related factor 2 (BRF-2) and similar proteins; BRF-2, also called ... |
1-28 | 6.64e-04 | ||
cyclin box found in B-related factor 2 (BRF-2) and similar proteins; BRF-2, also called transcription factor IIIB 50 kDa subunit (TFIIIB50), or BRFU, is a general activator of RNA polymerase (Pol) III transcription and is required for Pol III transcription of genes with promoter elements upstream of the initiation sites. It recruits Pol III to type III gene-external promoters, including the U6 spliceosomal RNA and selenocysteine tRNA genes. BRF-2 contains one cyclin box. The cyclin box fold is generally a protein binding domain, but binds DNA in BRF-2. Pssm-ID: 410258 [Multi-domain] Cd Length: 97 Bit Score: 38.03 E-value: 6.64e-04
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