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Conserved domains on  [gi|568954949|ref|XP_006509546|]
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LRP2-binding protein isoform X1 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Gene Ontology:  GO:0005515
PubMed:  10517866|30708253

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
18-214 6.18e-29

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 108.86  E-value: 6.18e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954949  18 AAAYNLGRAYFEGKGVKRSDEEAERLWLLAADNGNPKAsvkaQSILGLFYSMKE--PKELEKAFFWHSEACGNGSLESQG 95
Cdd:COG0790   64 EAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEA----QYNLGLMYEEGLgvPQDYAKALEWYEKAAEQGDADAQY 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954949  96 ALGLMYFYGQGIRQDTDAALHCLREAAERGNVYAQGTLVEYYYKMKF----FTKCVSFSKRIADydevhdipmiahvtdc 171
Cdd:COG0790  140 NLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGvpkdPAKALEWYRKAAE---------------- 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 568954949 172 lpefiiKGMAMAAFYHGRCLQLGLGIMKDEESAKHYYSKACRL 214
Cdd:COG0790  204 ------QGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
18-214 6.18e-29

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 108.86  E-value: 6.18e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954949  18 AAAYNLGRAYFEGKGVKRSDEEAERLWLLAADNGNPKAsvkaQSILGLFYSMKE--PKELEKAFFWHSEACGNGSLESQG 95
Cdd:COG0790   64 EAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEA----QYNLGLMYEEGLgvPQDYAKALEWYEKAAEQGDADAQY 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954949  96 ALGLMYFYGQGIRQDTDAALHCLREAAERGNVYAQGTLVEYYYKMKF----FTKCVSFSKRIADydevhdipmiahvtdc 171
Cdd:COG0790  140 NLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGvpkdPAKALEWYRKAAE---------------- 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 568954949 172 lpefiiKGMAMAAFYHGRCLQLGLGIMKDEESAKHYYSKACRL 214
Cdd:COG0790  204 ------QGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 92-126 9.98e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 41.39  E-value: 9.98e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568954949    92 ESQGALGLMYFYGQGIRQDTDAALHCLREAAERGN 126
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 18-51 2.39e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.20  E-value: 2.39e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568954949   18 AAAYNLGRAYFEGKGVKRSDEEAERLWLLAADNG 51
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
18-214 6.18e-29

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 108.86  E-value: 6.18e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954949  18 AAAYNLGRAYFEGKGVKRSDEEAERLWLLAADNGNPKAsvkaQSILGLFYSMKE--PKELEKAFFWHSEACGNGSLESQG 95
Cdd:COG0790   64 EAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEA----QYNLGLMYEEGLgvPQDYAKALEWYEKAAEQGDADAQY 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954949  96 ALGLMYFYGQGIRQDTDAALHCLREAAERGNVYAQGTLVEYYYKMKF----FTKCVSFSKRIADydevhdipmiahvtdc 171
Cdd:COG0790  140 NLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGvpkdPAKALEWYRKAAE---------------- 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 568954949 172 lpefiiKGMAMAAFYHGRCLQLGLGIMKDEESAKHYYSKACRL 214
Cdd:COG0790  204 ------QGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
18-215 1.05e-18

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 81.51  E-value: 1.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954949  18 AAAYNLGRAYFEGKGVKRSDEEAERLWLLAADNGNPKASVKAQSILGLFYSMKE--PKELEKAFFWHSEACGNGSLESQG 95
Cdd:COG0790   24 AAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRgvPKDYEKALEWFEKAAEQGDAEAQY 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954949  96 ALGLMYFYGQGIRQDTDAALHCLREAAERGNVYAQGTLVEYYYKMKFFTKcvSFSKRIADYDEVHDipmiahvtdclpef 175
Cdd:COG0790  104 NLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPK--DPAKAAEWYRKAAE-------------- 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 568954949 176 iiKGMAMAAFYHGRCLQLGLGIMKDEESAKHYYSKACRLN 215
Cdd:COG0790  168 --QGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQG 205
TPR COG0790
TPR repeat [General function prediction only];
40-215 2.03e-11

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 61.48  E-value: 2.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954949  40 AERLWLLAADNGNPKASVKAQSILGLFYSMKEPKELEKAFFWHSEACGNGSLESQGALGLMYFYGQGIRQDTDAALHCLR 119
Cdd:COG0790   12 AAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568954949 120 EAAERGNVYAQGTLVEYYYK----MKFFTKCVSFSKRIADydevhdipmiahvtdclpefiiKGMAMAAFYHGRCLQLGL 195
Cdd:COG0790   92 KAAEQGDAEAQYNLGLMYEEglgvPQDYAKALEWYEKAAE----------------------QGDADAQYNLGLLYLNGE 149

                        170       180
                 ....*....|....*....|
gi 568954949 196 GIMKDEESAKHYYSKACRLN 215
Cdd:COG0790  150 GVPKDPAKAAEWYRKAAEQG 169
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 92-126 9.98e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 41.39  E-value: 9.98e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568954949    92 ESQGALGLMYFYGQGIRQDTDAALHCLREAAERGN 126
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 19-52 1.17e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 41.01  E-value: 1.17e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568954949    19 AAYNLGRAYFEGKGVKRSDEEAERLWLLAADNGN 52
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 18-51 2.39e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.20  E-value: 2.39e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568954949   18 AAAYNLGRAYFEGKGVKRSDEEAERLWLLAADNG 51
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 92-125 2.83e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.20  E-value: 2.83e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568954949   92 ESQGALGLMYFYGQGIRQDTDAALHCLREAAERG 125
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 181-215 2.40e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.54  E-value: 2.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 568954949   181 AMAAFYHGRCLQLGLGIMKDEESAKHYYSKACRLN 215
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 181-215 3.89e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 36.73  E-value: 3.89e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568954949  181 AMAAFYHGRCLQLGLGIMKDEESAKHYYSKACRLN 215
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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