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Conserved domains on  [gi|568958875|ref|XP_006510087|]
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interleukin-18 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_IL18 cd23298
beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called ...
 61-206 2.88e-50

beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


:

Pssm-ID: 466780  Cd Length: 149  Bit Score: 160.07  E-value: 2.88e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958875  61 HCTTAVIRNINDQVLFVDKR-QPVFEDMTDIDQSasEPQTRLIIYMYKDSEV-RGLAVTLSV-KDSKMSTLSCK-NKIIS 136
Cdd:cd23298    1 KSKTSIIRNKDNKFLVLDPDgQFVFEDLTDQELN--APDCKFTIQIYKDTSPpRGLPVALYVkKDGKTYVLCCEeNKEIR 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568958875 137 FEEMDPPENIDDIQSDLIFFQKRVP-GHNKMEFESSLYEGHFLACQKEDDAFKLILKKKDENGDKSVMFTL 206
Cdd:cd23298   79 FKEMDLPDDIEGTKSDAIFYQKKFPgGTNKYKFESSLYPGYFLAFEPENDLFKLVLKKKDDEVDETCEFTV 149
 
Name Accession Description Interval E-value
beta-trefoil_IL18 cd23298
beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called ...
 61-206 2.88e-50

beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466780  Cd Length: 149  Bit Score: 160.07  E-value: 2.88e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958875  61 HCTTAVIRNINDQVLFVDKR-QPVFEDMTDIDQSasEPQTRLIIYMYKDSEV-RGLAVTLSV-KDSKMSTLSCK-NKIIS 136
Cdd:cd23298    1 KSKTSIIRNKDNKFLVLDPDgQFVFEDLTDQELN--APDCKFTIQIYKDTSPpRGLPVALYVkKDGKTYVLCCEeNKEIR 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568958875 137 FEEMDPPENIDDIQSDLIFFQKRVP-GHNKMEFESSLYEGHFLACQKEDDAFKLILKKKDENGDKSVMFTL 206
Cdd:cd23298   79 FKEMDLPDDIEGTKSDAIFYQKKFPgGTNKYKFESSLYPGYFLAFEPENDLFKLVLKKKDDEVDETCEFTV 149
IL1 pfam00340
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.
 96-202 4.86e-25

Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.


Pssm-ID: 395269  Cd Length: 119  Bit Score: 94.44  E-value: 4.86e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958875   96 EPQTRLIIYMYK-DSEVRGLAVTLSVKDSKMsTLSCKNK---IISFEEMDPPENIDDIQSDLIF-FQKRVPGHNkMEFES 170
Cdd:pfam00340   7 NLEVKFDMSFYKgDSDDSKIPVTLGIKGKKL-YLSCVNKdepVLQLEEVNIPKLIKNKESDKRFfFIRSESKNY-VEFES 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 568958875  171 SLYEGHFLACQKEDDAFKLILK---KKDENGDKSV 202
Cdd:pfam00340  85 AAYPGWFIATKQEEDLPVFLVNtagGQDSITDFQI 119
IL1 smart00125
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ...
 114-185 3.05e-04

Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin.


Pssm-ID: 128430  Cd Length: 147  Bit Score: 39.67  E-value: 3.05e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568958875   114 LAVTLSVKDSKMsTLSCKNK----IISFEEMDPPENIDDiQSDLIFFQKRVPGHNKMEFESSLYEGHFLACQKEDD 185
Cdd:smart00125  54 IPVTLGISGTNL-YLSCVKKgdepTLQLEMVDPPKYPKK-EMEKRFVFEKHEIGNKVEFESAAHPNWFISTSQEED 127
 
Name Accession Description Interval E-value
beta-trefoil_IL18 cd23298
beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called ...
 61-206 2.88e-50

beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466780  Cd Length: 149  Bit Score: 160.07  E-value: 2.88e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958875  61 HCTTAVIRNINDQVLFVDKR-QPVFEDMTDIDQSasEPQTRLIIYMYKDSEV-RGLAVTLSV-KDSKMSTLSCK-NKIIS 136
Cdd:cd23298    1 KSKTSIIRNKDNKFLVLDPDgQFVFEDLTDQELN--APDCKFTIQIYKDTSPpRGLPVALYVkKDGKTYVLCCEeNKEIR 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568958875 137 FEEMDPPENIDDIQSDLIFFQKRVP-GHNKMEFESSLYEGHFLACQKEDDAFKLILKKKDENGDKSVMFTL 206
Cdd:cd23298   79 FKEMDLPDDIEGTKSDAIFYQKKFPgGTNKYKFESSLYPGYFLAFEPENDLFKLVLKKKDDEVDETCEFTV 149
IL1 pfam00340
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.
 96-202 4.86e-25

Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.


Pssm-ID: 395269  Cd Length: 119  Bit Score: 94.44  E-value: 4.86e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958875   96 EPQTRLIIYMYK-DSEVRGLAVTLSVKDSKMsTLSCKNK---IISFEEMDPPENIDDIQSDLIF-FQKRVPGHNkMEFES 170
Cdd:pfam00340   7 NLEVKFDMSFYKgDSDDSKIPVTLGIKGKKL-YLSCVNKdepVLQLEEVNIPKLIKNKESDKRFfFIRSESKNY-VEFES 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 568958875  171 SLYEGHFLACQKEDDAFKLILK---KKDENGDKSV 202
Cdd:pfam00340  85 AAYPGWFIATKQEEDLPVFLVNtagGQDSITDFQI 119
beta-trefoil_IL1 cd00100
beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of ...
 64-206 4.70e-18

beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of cytokines comprises 11 members, including 7 pro-inflammatory agonists (IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, IL-36gamma) and 4 defined or putative antagonists (IL-1R antagonist (IL-1Ra), IL-36Ra, IL-37, and IL-38) exerting anti-inflammatory activities. These members can have complimentary or distinct biological functions. All family members share a common structure at the C-terminus, which is comprised by of a typical beta-trefoil fold consisting of 12-beta-strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466776  Cd Length: 145  Bit Score: 76.98  E-value: 4.70e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958875  64 TAVIRNINDQVLFVD-KRQPVFEDMTDIDQSASepqtrLIIYMYKDSEV---RGLAVTLSVKDsKMSTLSC----KNKII 135
Cdd:cd00100    4 NFVIRDSNDKSLYLRgNNELVAEDLSDVEKSAK-----ITIYYYKSDSDedfKGIPVVLNFTG-TNCFLSCvkegDKPSL 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568958875 136 SFEEMDPPE--NIDDIQSDLIFFQKRVPGhNKMEFESSLYEGHFLACQKEDdafKLILKKKDENgDKSVMFTL 206
Cdd:cd00100   78 QLEECNKEElkNGDEEEWPFVFYMKASHD-NTCRFESAAHPGWFICTKKDQ---PVGLTKELGK-TEDTDFYF 145
beta-trefoil_IL1A cd23295
beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, ...
 103-185 6.99e-05

beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, also called hematopoietin-1, is a potent inflammatory cytokine that activates the inflammatory process. It is produced by activated macrophages. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 alpha contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466777  Cd Length: 145  Bit Score: 41.55  E-value: 6.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568958875 103 IYMYKDSE-VRGLAVTLSVKDSKMSTLSCK-NKIISFEEMDP-PENIDDIQSDLIFFQKRvpgHNKMEFESSLYEGHFLA 179
Cdd:cd23295   46 IGAYKSLDdDYKIPVTLRISNTQLFVSAQGeDEPVLLKEMPEtPKTITGSETNLLFFWEE---HGTKNFFSSAANPELFA 122


                 ....*.
gi 568958875 180 CQKEDD 185
Cdd:cd23295  123 ATKQDE 128
IL1 smart00125
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ...
 114-185 3.05e-04

Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin.


Pssm-ID: 128430  Cd Length: 147  Bit Score: 39.67  E-value: 3.05e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568958875   114 LAVTLSVKDSKMsTLSCKNK----IISFEEMDPPENIDDiQSDLIFFQKRVPGHNKMEFESSLYEGHFLACQKEDD 185
Cdd:smart00125  54 IPVTLGISGTNL-YLSCVKKgdepTLQLEMVDPPKYPKK-EMEKRFVFEKHEIGNKVEFESAAHPNWFISTSQEED 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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