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Conserved domains on  [gi|568959674|ref|XP_006510480|]
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protein PTHB1 isoform X1 [Mus musculus]

Protein Classification

protein PTHB1( domain architecture ID 11236376)

protein PTHB1 is part of the BBSome complex that may function as a coat complex required for sorting of specific membrane proteins to the primary cilia

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PHTB1_N pfam14727
PTHB1 N-terminus; This family includes the N-terminus of PTHB1 protein. This protein forms a ...
1-417 0e+00

PTHB1 N-terminus; This family includes the N-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis.


:

Pssm-ID: 464284  Cd Length: 416  Bit Score: 666.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674    1 MSLFKARDWWSTVLGEKEEFDQGCLCLADVDNSGNGHDKIIVGSFMGYLRIFSPHSvkaGGGPQAEDLLLEVHLRDPVLQ 80
Cdd:pfam14727   1 MSLFKAREWWSTTCGEGEEFDQGSLLVGNLDNEGQGSDKIIVGSLSGVLRIYSPSS---RGGFQPEDLLLETQLKEPILQ 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674   81 VEVGKFVSGTEMLHLAVLHSRKLCVYSV--SGTLGNVEHGNQYQIKLMYEHHLQRTACNMTYGPFGGVKGRDLICIQSLD 158
Cdd:pfam14727  78 VEVGKFVSGSRNLHLAVLHPRKLVVYTVeaLGSQGNVEHGNQYQLELIYEHNLQRTAYNMCVGPFGGVKGRDFICVQSMD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  159 GMLMVFEQESYAFGRFLPGFLLPGPLAYSPRTDSFITVSSCRQVESYKYQVLAFATDADKKQEMEQqkLGSGKRLVVDWT 238
Cdd:pfam14727 158 GALSFFEQDSFAFGRFLPGFLLPGPLAYCQRTDSFVTANSSWELECYKYQALASASESDSKGSDEN--KSSGKKLTPDWS 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  239 LNIGEQALDICIFPLNQSASSVFVLGERNFFCLKDNGQIRFMKKLGYNPSCFLPYCSV----SEGTINTLIGNHNHMLHI 314
Cdd:pfam14727 236 FNLGEQALDINVVSFSESSSSIIVLGERSLFCLKDNGQLRFQKRLDYVPSCFAPYRSLqknnPEGSINLLVATHTGTLLV 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  315 YQDVTLKWATQLPHVPVAVRVGCFHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDVELKELQKIIKD 394
Cdd:pfam14727 316 YEDTTLKWAAQLPFVPVALAVANFNDLKGLIVSLSEDGTLSVSYLGTDPSLFQVPPLESREINYEEADEELKELQKIIKE 395
                         410       420
                  ....*....|....*....|...
gi 568959674  395 VKLQGvwPLTEQEDDLKVSASVS 417
Cdd:pfam14727 396 ASASG--DAIEAKEELTINVSIS 416
PHTB1_C pfam14728
PTHB1 C-terminus; This family includes the C-terminus of PTHB1 protein. This protein forms a ...
440-818 0e+00

PTHB1 C-terminus; This family includes the C-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis.


:

Pssm-ID: 464285  Cd Length: 376  Bit Score: 598.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  440 TVKITLQNRVVLQKVKLSIYVQPPLQLTCDQFTFDFTVPDMTSSVAFSVYLKRNYTPSELEGNAVVSYSRPTdrnpdGIP 519
Cdd:pfam14728   1 TVKVTIKSRTTLENVQLSVQVPPPLVATPSTFVIENLDPSSSTELITSIFLSGLYIPSSLEVVVVASYTTPT-----GVP 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  520 RVVQCKFRLPLKLICLPGQPSKTASHKLTIDTNKSPVSLLGLFPDFANPSDDDQVNVMGFRLLGGARVTLLASRTSQRYR 599
Cdd:pfam14728  76 RVVQCSANLPLKLVCRPCQPVKTATHKLTIDTNKSPVSLSELFPDFLPDEEGSTGNALGFQYLNGSVVTILASKTSQRYR 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  600 IQSEQFEDLWLITNELILRLQEHFEKQGTKD-FSCSFSGCVPLQEYFELIDHHFELRINGKKLEELLSERAVQFRAIQRR 678
Cdd:pfam14728 156 IQSDSFEALWLVLKELVRRLQAHFSKQGNKDaFKISFSGPLPLQEYFELIDTHFELRLEAEKLQELLSERASQFRAIQKR 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  679 LLTRFRDKTPAPLQHLDTLLDGTYKQVIALADAIEENQDRLLQSFSGLKSATHLLILLIRLWQRLSADQTAILEAAFLPL 758
Cdd:pfam14728 236 LLTRFKDKTPAPLQNLDTLLEGTYRQLIALADALEEAEAALRQAFNRLNSATQLLLLLLKLWQNLNEDQANILEAAFSPL 315
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568959674  759 QEDTQELGWEETVDAAIAYLLKTCLSKSSKEQALNLS-SQLNIPKDTSRLKKHITLLCDRL 818
Cdd:pfam14728 316 VSDSLDQGWEESTDAALSHLLRTCLSKSSKDQALPPNlSQLEIPKDTSKLKKHITLLCDRL 376
 
Name Accession Description Interval E-value
PHTB1_N pfam14727
PTHB1 N-terminus; This family includes the N-terminus of PTHB1 protein. This protein forms a ...
1-417 0e+00

PTHB1 N-terminus; This family includes the N-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis.


Pssm-ID: 464284  Cd Length: 416  Bit Score: 666.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674    1 MSLFKARDWWSTVLGEKEEFDQGCLCLADVDNSGNGHDKIIVGSFMGYLRIFSPHSvkaGGGPQAEDLLLEVHLRDPVLQ 80
Cdd:pfam14727   1 MSLFKAREWWSTTCGEGEEFDQGSLLVGNLDNEGQGSDKIIVGSLSGVLRIYSPSS---RGGFQPEDLLLETQLKEPILQ 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674   81 VEVGKFVSGTEMLHLAVLHSRKLCVYSV--SGTLGNVEHGNQYQIKLMYEHHLQRTACNMTYGPFGGVKGRDLICIQSLD 158
Cdd:pfam14727  78 VEVGKFVSGSRNLHLAVLHPRKLVVYTVeaLGSQGNVEHGNQYQLELIYEHNLQRTAYNMCVGPFGGVKGRDFICVQSMD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  159 GMLMVFEQESYAFGRFLPGFLLPGPLAYSPRTDSFITVSSCRQVESYKYQVLAFATDADKKQEMEQqkLGSGKRLVVDWT 238
Cdd:pfam14727 158 GALSFFEQDSFAFGRFLPGFLLPGPLAYCQRTDSFVTANSSWELECYKYQALASASESDSKGSDEN--KSSGKKLTPDWS 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  239 LNIGEQALDICIFPLNQSASSVFVLGERNFFCLKDNGQIRFMKKLGYNPSCFLPYCSV----SEGTINTLIGNHNHMLHI 314
Cdd:pfam14727 236 FNLGEQALDINVVSFSESSSSIIVLGERSLFCLKDNGQLRFQKRLDYVPSCFAPYRSLqknnPEGSINLLVATHTGTLLV 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  315 YQDVTLKWATQLPHVPVAVRVGCFHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDVELKELQKIIKD 394
Cdd:pfam14727 316 YEDTTLKWAAQLPFVPVALAVANFNDLKGLIVSLSEDGTLSVSYLGTDPSLFQVPPLESREINYEEADEELKELQKIIKE 395
                         410       420
                  ....*....|....*....|...
gi 568959674  395 VKLQGvwPLTEQEDDLKVSASVS 417
Cdd:pfam14727 396 ASASG--DAIEAKEELTINVSIS 416
PHTB1_C pfam14728
PTHB1 C-terminus; This family includes the C-terminus of PTHB1 protein. This protein forms a ...
440-818 0e+00

PTHB1 C-terminus; This family includes the C-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis.


Pssm-ID: 464285  Cd Length: 376  Bit Score: 598.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  440 TVKITLQNRVVLQKVKLSIYVQPPLQLTCDQFTFDFTVPDMTSSVAFSVYLKRNYTPSELEGNAVVSYSRPTdrnpdGIP 519
Cdd:pfam14728   1 TVKVTIKSRTTLENVQLSVQVPPPLVATPSTFVIENLDPSSSTELITSIFLSGLYIPSSLEVVVVASYTTPT-----GVP 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  520 RVVQCKFRLPLKLICLPGQPSKTASHKLTIDTNKSPVSLLGLFPDFANPSDDDQVNVMGFRLLGGARVTLLASRTSQRYR 599
Cdd:pfam14728  76 RVVQCSANLPLKLVCRPCQPVKTATHKLTIDTNKSPVSLSELFPDFLPDEEGSTGNALGFQYLNGSVVTILASKTSQRYR 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  600 IQSEQFEDLWLITNELILRLQEHFEKQGTKD-FSCSFSGCVPLQEYFELIDHHFELRINGKKLEELLSERAVQFRAIQRR 678
Cdd:pfam14728 156 IQSDSFEALWLVLKELVRRLQAHFSKQGNKDaFKISFSGPLPLQEYFELIDTHFELRLEAEKLQELLSERASQFRAIQKR 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  679 LLTRFRDKTPAPLQHLDTLLDGTYKQVIALADAIEENQDRLLQSFSGLKSATHLLILLIRLWQRLSADQTAILEAAFLPL 758
Cdd:pfam14728 236 LLTRFKDKTPAPLQNLDTLLEGTYRQLIALADALEEAEAALRQAFNRLNSATQLLLLLLKLWQNLNEDQANILEAAFSPL 315
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568959674  759 QEDTQELGWEETVDAAIAYLLKTCLSKSSKEQALNLS-SQLNIPKDTSRLKKHITLLCDRL 818
Cdd:pfam14728 316 VSDSLDQGWEESTDAALSHLLRTCLSKSSKDQALPPNlSQLEIPKDTSKLKKHITLLCDRL 376
 
Name Accession Description Interval E-value
PHTB1_N pfam14727
PTHB1 N-terminus; This family includes the N-terminus of PTHB1 protein. This protein forms a ...
1-417 0e+00

PTHB1 N-terminus; This family includes the N-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis.


Pssm-ID: 464284  Cd Length: 416  Bit Score: 666.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674    1 MSLFKARDWWSTVLGEKEEFDQGCLCLADVDNSGNGHDKIIVGSFMGYLRIFSPHSvkaGGGPQAEDLLLEVHLRDPVLQ 80
Cdd:pfam14727   1 MSLFKAREWWSTTCGEGEEFDQGSLLVGNLDNEGQGSDKIIVGSLSGVLRIYSPSS---RGGFQPEDLLLETQLKEPILQ 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674   81 VEVGKFVSGTEMLHLAVLHSRKLCVYSV--SGTLGNVEHGNQYQIKLMYEHHLQRTACNMTYGPFGGVKGRDLICIQSLD 158
Cdd:pfam14727  78 VEVGKFVSGSRNLHLAVLHPRKLVVYTVeaLGSQGNVEHGNQYQLELIYEHNLQRTAYNMCVGPFGGVKGRDFICVQSMD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  159 GMLMVFEQESYAFGRFLPGFLLPGPLAYSPRTDSFITVSSCRQVESYKYQVLAFATDADKKQEMEQqkLGSGKRLVVDWT 238
Cdd:pfam14727 158 GALSFFEQDSFAFGRFLPGFLLPGPLAYCQRTDSFVTANSSWELECYKYQALASASESDSKGSDEN--KSSGKKLTPDWS 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  239 LNIGEQALDICIFPLNQSASSVFVLGERNFFCLKDNGQIRFMKKLGYNPSCFLPYCSV----SEGTINTLIGNHNHMLHI 314
Cdd:pfam14727 236 FNLGEQALDINVVSFSESSSSIIVLGERSLFCLKDNGQLRFQKRLDYVPSCFAPYRSLqknnPEGSINLLVATHTGTLLV 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  315 YQDVTLKWATQLPHVPVAVRVGCFHDLKGVIVTLSDDGHLQCSYLGTDPSLFQAPKVESRELNYDELDVELKELQKIIKD 394
Cdd:pfam14727 316 YEDTTLKWAAQLPFVPVALAVANFNDLKGLIVSLSEDGTLSVSYLGTDPSLFQVPPLESREINYEEADEELKELQKIIKE 395
                         410       420
                  ....*....|....*....|...
gi 568959674  395 VKLQGvwPLTEQEDDLKVSASVS 417
Cdd:pfam14727 396 ASASG--DAIEAKEELTINVSIS 416
PHTB1_C pfam14728
PTHB1 C-terminus; This family includes the C-terminus of PTHB1 protein. This protein forms a ...
440-818 0e+00

PTHB1 C-terminus; This family includes the C-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis.


Pssm-ID: 464285  Cd Length: 376  Bit Score: 598.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  440 TVKITLQNRVVLQKVKLSIYVQPPLQLTCDQFTFDFTVPDMTSSVAFSVYLKRNYTPSELEGNAVVSYSRPTdrnpdGIP 519
Cdd:pfam14728   1 TVKVTIKSRTTLENVQLSVQVPPPLVATPSTFVIENLDPSSSTELITSIFLSGLYIPSSLEVVVVASYTTPT-----GVP 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  520 RVVQCKFRLPLKLICLPGQPSKTASHKLTIDTNKSPVSLLGLFPDFANPSDDDQVNVMGFRLLGGARVTLLASRTSQRYR 599
Cdd:pfam14728  76 RVVQCSANLPLKLVCRPCQPVKTATHKLTIDTNKSPVSLSELFPDFLPDEEGSTGNALGFQYLNGSVVTILASKTSQRYR 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  600 IQSEQFEDLWLITNELILRLQEHFEKQGTKD-FSCSFSGCVPLQEYFELIDHHFELRINGKKLEELLSERAVQFRAIQRR 678
Cdd:pfam14728 156 IQSDSFEALWLVLKELVRRLQAHFSKQGNKDaFKISFSGPLPLQEYFELIDTHFELRLEAEKLQELLSERASQFRAIQKR 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568959674  679 LLTRFRDKTPAPLQHLDTLLDGTYKQVIALADAIEENQDRLLQSFSGLKSATHLLILLIRLWQRLSADQTAILEAAFLPL 758
Cdd:pfam14728 236 LLTRFKDKTPAPLQNLDTLLEGTYRQLIALADALEEAEAALRQAFNRLNSATQLLLLLLKLWQNLNEDQANILEAAFSPL 315
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568959674  759 QEDTQELGWEETVDAAIAYLLKTCLSKSSKEQALNLS-SQLNIPKDTSRLKKHITLLCDRL 818
Cdd:pfam14728 316 VSDSLDQGWEESTDAALSHLLRTCLSKSSKDQALPPNlSQLEIPKDTSKLKKHITLLCDRL 376
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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