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Conserved domains on  [gi|568960943|ref|XP_006510969|]
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thrombospondin type-1 domain-containing protein 4 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 413-528 1.27e-34

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 128.08  E-value: 1.27e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960943   413 VVSGVFKHALtSLGYHRVVEIPQGATKINITEMHKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpnevS 491
Cdd:pfam05986    1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 568960943   492 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 528
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 317-411 2.85e-13

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 67.04  E-value: 2.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960943   317 QCASYNNKPFM-----GRFYEW-EPFAEVKGNRKCELNCQATGYRFYVRQAEKVIDGTPCDQNGT------AICVSGQCK 384
Cdd:pfam19236    9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPredgtlSLCVLGSCR 88

                           90       100
                   ....*....|....*....|....*..
gi 568960943   385 SIGCDDFLGSDKVLDKCGVCGGDNTGC 411
Cdd:pfam19236   89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 856-912 6.06e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.40  E-value: 6.06e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568960943   856 WFTGSWSQCSIECGSGTQQREVICVRKnaDTFEVLDPYECSFLEKPPSQQACHLKPC 912
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 680-736 6.37e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 6.37e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568960943   680 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRslTVQPYRCQHLEKPETTSTCQLKIC 736
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 975-1005 6.97e-11

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


:

Pssm-ID: 462560  Cd Length: 31  Bit Score: 57.55  E-value: 6.97e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568960943   975 CKDKYYNCNVVVQARLCVYNYYKTACCASCT 1005
Cdd:pfam08686    1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 916-967 7.35e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.23  E-value: 7.35e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568960943   916 WFSTEWSMCSKSCQGGFRVREVRC---LSDDMTPSSLCDPQLKPEERESCNTQDC 967
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 739-793 8.94e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.23  E-value: 8.94e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568960943   739 WQIrTDWTSCSVPCGVGQRTRDVKCV-SNIGDMVHDEECNMKLRPNDIENCDMGPC 793
Cdd:pfam19030    1 WVA-GPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 627-676 2.23e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 2.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 568960943   627 TECSTTCGKGSQYPIFRCVHRNTHEEVPESYCDSSMKPtPEEEPCNLFPC 676
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 797-850 2.94e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 45.14  E-value: 2.94e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568960943   797 WFLTEWSErCSAECGAGVRTRSVVCMTNHVSSL-PLEGCGNN-RPVEATPCDNGPC 850
Cdd:pfam19030    1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQkKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 57-81 1.61e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.26  E-value: 1.61e-04
                            10        20
                    ....*....|....*....|....*
gi 568960943     57 WGSWGPWSACSRSCSGGVMEQTRPC 81
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSC 25
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 413-528 1.27e-34

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 128.08  E-value: 1.27e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960943   413 VVSGVFKHALtSLGYHRVVEIPQGATKINITEMHKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpnevS 491
Cdd:pfam05986    1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 568960943   492 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 528
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 317-411 2.85e-13

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 67.04  E-value: 2.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960943   317 QCASYNNKPFM-----GRFYEW-EPFAEVKGNRKCELNCQATGYRFYVRQAEKVIDGTPCDQNGT------AICVSGQCK 384
Cdd:pfam19236    9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPredgtlSLCVLGSCR 88

                           90       100
                   ....*....|....*....|....*..
gi 568960943   385 SIGCDDFLGSDKVLDKCGVCGGDNTGC 411
Cdd:pfam19236   89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 856-912 6.06e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.40  E-value: 6.06e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568960943   856 WFTGSWSQCSIECGSGTQQREVICVRKnaDTFEVLDPYECSFLEKPPSQQACHLKPC 912
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 680-736 6.37e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 6.37e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568960943   680 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRslTVQPYRCQHLEKPETTSTCQLKIC 736
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 975-1005 6.97e-11

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 57.55  E-value: 6.97e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568960943   975 CKDKYYNCNVVVQARLCVYNYYKTACCASCT 1005
Cdd:pfam08686    1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 916-967 7.35e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.23  E-value: 7.35e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568960943   916 WFSTEWSMCSKSCQGGFRVREVRC---LSDDMTPSSLCDPQLKPEERESCNTQDC 967
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 739-793 8.94e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.23  E-value: 8.94e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568960943   739 WQIrTDWTSCSVPCGVGQRTRDVKCV-SNIGDMVHDEECNMKLRPNDIENCDMGPC 793
Cdd:pfam19030    1 WVA-GPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 627-676 2.23e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 2.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 568960943   627 TECSTTCGKGSQYPIFRCVHRNTHEEVPESYCDSSMKPtPEEEPCNLFPC 676
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 797-850 2.94e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 45.14  E-value: 2.94e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568960943   797 WFLTEWSErCSAECGAGVRTRSVVCMTNHVSSL-PLEGCGNN-RPVEATPCDNGPC 850
Cdd:pfam19030    1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQkKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 919-967 5.57e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.80  E-value: 5.57e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 568960943    919 TEWSMCSKSCQGGFRVREVRCLSDDMT-PSSLCDPQLKpeERESCNTQDC 967
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQnGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 736-793 1.32e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.65  E-value: 1.32e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 568960943    736 CSEWqirTDWTSCSVPCGVGQRTRDVKCVSNIGDmVHDEECNMKLRpnDIENCDMGPC 793
Cdd:smart00209    1 WSEW---SEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 57-81 1.61e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.26  E-value: 1.61e-04
                            10        20
                    ....*....|....*....|....*
gi 568960943     57 WGSWGPWSACSRSCSGGVMEQTRPC 81
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSC 25
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 680-703 4.03e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 4.03e-04
                            10        20
                    ....*....|....*....|....
gi 568960943    680 WDIGEWSECSKTCGLGMQHRQVLC 703
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSC 25
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 856-912 5.01e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 5.01e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 568960943    856 WFTGSWSQCSIECGSGTQQREVICVRKNADtfevLDPYECSflEKPPSQQACHLKPC 912
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ----NGGGPCT--GEDVETRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 58-79 5.99e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 35.72  E-value: 5.99e-03
                           10        20
                   ....*....|....*....|..
gi 568960943    58 GSWGPWSACSRSCSGGVMEQTR 79
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTR 25
 
Name Accession Description Interval E-value
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 413-528 1.27e-34

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 128.08  E-value: 1.27e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960943   413 VVSGVFKHALtSLGYHRVVEIPQGATKINITEMHKSNNYLALRSRSGRSIINGNWAID-RPGKYEGGGTMFTYKRpnevS 491
Cdd:pfam05986    1 TVSGSFTEGR-AKGYVTFVTIPAGATHIHIVNRKPSFTHLAVKNVQGKYILNGKGSISlNPTYPSLLGTVLEYRR----S 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 568960943   492 STAGESFLAEGPTNEILDVYMIHQ---QPNPGVHYEYVIM 528
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQygkGTNPGITYEYFIP 115
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 317-411 2.85e-13

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 67.04  E-value: 2.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568960943   317 QCASYNNKPFM-----GRFYEW-EPFAEVKGNRKCELNCQATGYRFYVRQAEKVIDGTPCDQNGT------AICVSGQCK 384
Cdd:pfam19236    9 QCARTDGQPLRsspggASFYHWgAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPredgtlSLCVLGSCR 88

                           90       100
                   ....*....|....*....|....*..
gi 568960943   385 SIGCDDFLGSDKVLDKCGVCGGDNTGC 411
Cdd:pfam19236   89 TFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 856-912 6.06e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.40  E-value: 6.06e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568960943   856 WFTGSWSQCSIECGSGTQQREVICVRKnaDTFEVLDPYECSFLEKPPSQQACHLKPC 912
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQK--GGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 680-736 6.37e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.01  E-value: 6.37e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568960943   680 WDIGEWSECSKTCGLGMQHRQVLCRQVYANRslTVQPYRCQHLEKPETTSTCQLKIC 736
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGS--IVPDSECSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 975-1005 6.97e-11

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 57.55  E-value: 6.97e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568960943   975 CKDKYYNCNVVVQARLCVYNYYKTACCASCT 1005
Cdd:pfam08686    1 CKDKFANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 916-967 7.35e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.23  E-value: 7.35e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568960943   916 WFSTEWSMCSKSCQGGFRVREVRC---LSDDMTPSSLCDPQLKPEERESCNTQDC 967
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 739-793 8.94e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 58.23  E-value: 8.94e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568960943   739 WQIrTDWTSCSVPCGVGQRTRDVKCV-SNIGDMVHDEECNMKLRPNDIENCDMGPC 793
Cdd:pfam19030    1 WVA-GPWGECSVTCGGGVQTRLVQCVqKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 627-676 2.23e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 54.00  E-value: 2.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 568960943   627 TECSTTCGKGSQYPIFRCVHRNTHEEVPESYCDSSMKPtPEEEPCNLFPC 676
Cdd:pfam19030    7 GECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 797-850 2.94e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 45.14  E-value: 2.94e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568960943   797 WFLTEWSErCSAECGAGVRTRSVVCMTNHVSSL-PLEGCGNN-RPVEATPCDNGPC 850
Cdd:pfam19030    1 WVAGPWGE-CSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQkKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 919-967 5.57e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.80  E-value: 5.57e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 568960943    919 TEWSMCSKSCQGGFRVREVRCLSDDMT-PSSLCDPQLKpeERESCNTQDC 967
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQnGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 736-793 1.32e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.65  E-value: 1.32e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 568960943    736 CSEWqirTDWTSCSVPCGVGQRTRDVKCVSNIGDmVHDEECNMKLRpnDIENCDMGPC 793
Cdd:smart00209    1 WSEW---SEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 57-81 1.61e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 40.26  E-value: 1.61e-04
                            10        20
                    ....*....|....*....|....*
gi 568960943     57 WGSWGPWSACSRSCSGGVMEQTRPC 81
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSC 25
TSP_1 pfam00090
Thrombospondin type 1 domain;
737-793 3.27e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 39.32  E-value: 3.27e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568960943   737 SEWqirTDWTSCSVPCGVGQRTRDVKCVSNIGDmvhDEECNMKLRPNDIenCDMGPC 793
Cdd:pfam00090    1 SPW---SPWSPCSVTCGKGIQVRQRTCKSPFPG---GEPCTGDDIETQA--CKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 680-703 4.03e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 4.03e-04
                            10        20
                    ....*....|....*....|....
gi 568960943    680 WDIGEWSECSKTCGLGMQHRQVLC 703
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSC 25
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 683-716 1.11e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 38.03  E-value: 1.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568960943   683 GEWSECSKTCGLGMQHRQvlcrqvyanRSLTVQP 716
Cdd:pfam19028    7 SEWSECSVTCGGGVQTRT---------RTVIVEP 31
TSP_1 pfam00090
Thrombospondin type 1 domain;
683-703 1.50e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.40  E-value: 1.50e-03
                           10        20
                   ....*....|....*....|.
gi 568960943   683 GEWSECSKTCGLGMQHRQVLC 703
Cdd:pfam00090    4 SPWSPCSVTCGKGIQVRQRTC 24
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 856-912 5.01e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 5.01e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 568960943    856 WFTGSWSQCSIECGSGTQQREVICVRKNADtfevLDPYECSflEKPPSQQACHLKPC 912
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ----NGGGPCT--GEDVETRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 58-79 5.99e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 35.72  E-value: 5.99e-03
                           10        20
                   ....*....|....*....|..
gi 568960943    58 GSWGPWSACSRSCSGGVMEQTR 79
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTR 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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