|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
19-455 |
0e+00 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 664.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 19 LAILAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKECAEHSAPIKVHHNHTGKKYKWDAETQGWILGSFFYGYIV 98
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPEHSSSPSVEHNETGKKYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 99 TQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTI 178
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 179 SYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVsdtpethktishyekeyivsslknqlssqkvvp 258
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV--------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 259 wgsilksLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTI 338
Cdd:cd17381 208 -------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFSTV 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 339 SVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGP 418
Cdd:cd17381 281 CVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMVGP 360
|
410 420 430
....*....|....*....|....*....|....*..
gi 568961401 419 IIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFA 455
Cdd:cd17381 361 VIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
20-455 |
3.34e-175 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 496.76 E-value: 3.34e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 20 AILAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKecaehsapIKVHHNHTGKKYKWDAETQGWILGSFFYGYIVT 99
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTST--------DKDTLPVEAPEFDWSEKTQGIILSSFFYGYILT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 100 QIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTIS 179
Cdd:cd17318 73 QIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 180 YAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVsdtpethktishyekeyivsslknqlssqkvvpw 259
Cdd:cd17318 153 YSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV---------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 260 gsilksLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTIS 339
Cdd:cd17318 199 ------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTT 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 340 VRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPI 419
Cdd:cd17318 273 VRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPL 352
|
410 420 430
....*....|....*....|....*....|....*..
gi 568961401 420 IAKSLTPDN-TIREWQTVFCIAAAINVFGAIFFTLFA 455
Cdd:cd17318 353 IVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
20-455 |
2.47e-120 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 356.65 E-value: 2.47e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 20 AILAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKECAEhsapikvhhnhtgkkYKWDAETQGWILGSFFYGYIVT 99
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIVHKAE---------------FNWTPETVGLIESSFFWGYLVT 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 100 QIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTIS 179
Cdd:cd17382 66 QIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 180 YAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIvsdtpethktishyekeyivsslknqlssqkvvpw 259
Cdd:cd17382 146 FCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV----------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 260 gsilkSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTIS 339
Cdd:cd17382 191 -----SMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTA 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 340 VRRIFSLVGMVGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPI 419
Cdd:cd17382 266 VRKIFNCGGFGMEATFLLVVAFSH-SPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPV 344
|
410 420 430
....*....|....*....|....*....|....*.
gi 568961401 420 IAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFA 455
Cdd:cd17382 345 IVGALTKHKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
10-468 |
1.54e-115 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 347.50 E-value: 1.54e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 10 PVCCSARYNLAILAFCGFFVLYALRVNLSVALVDMVDSnttltDNRTSKECAEHSAPIKVHHNhtgKKYKWDAETQGWIL 89
Cdd:TIGR00894 11 PYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNK-----ENSTDLACLSAENELDNIKN---PNFKWSGALQGLIL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 90 GSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPP 169
Cdd:TIGR00894 83 SSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 170 LERSKLLTISYAGAQLGTVISLPLSGIIC-YYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHYEKEYIVSSLK 248
Cdd:TIGR00894 163 KERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQ 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 249 NQ-LSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAAD 327
Cdd:TIGR00894 243 GQkGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLAD 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 328 YLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITN 407
Cdd:TIGR00894 323 FLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITG 402
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568961401 408 TFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFAKGEVQSWALSDHH 468
Cdd:TIGR00894 403 LPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKD 463
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
21-455 |
7.38e-103 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 311.41 E-value: 7.38e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 21 ILAFCGFFVLYALRVNLSVALVDMvdsnttltdnrtSKEcaehsapikvhhnhtgkkYKWDAETQGWILGSFFYGYIVTQ 100
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPM------------AKE------------------FGWSKTDQGLVLSSFFWGYALTQ 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 101 IPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISY 180
Cdd:cd17380 52 VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVT 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 181 AGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSdtpethktishyekeyivsslknqlssqkvvpwg 260
Cdd:cd17380 132 AGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP---------------------------------- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 261 silkslPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILrFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKwNFSTISV 340
Cdd:cd17380 178 ------PVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISR-GWTVTSV 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 341 RRIFSLVGMVGPAVFLVAAGFIgCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPII 420
Cdd:cd17380 250 RKLMQSIGFLGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYL 328
|
410 420 430
....*....|....*....|....*....|....*
gi 568961401 421 AKSLTpdNTIREWQTVFCIAAAINVFGAIFFTLFA 455
Cdd:cd17380 329 TGYIL--EATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
16-449 |
6.19e-45 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 160.43 E-value: 6.19e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 16 RYNLAILAFCGFFVLYALRVNLSVALVDMvdsnttltdnrtskecaehsapikvhhnhtGKKYKWDAETQGWILGSFFYG 95
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTI------------------------------MKDLGLSPTQYGLIASAFFLG 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 96 YIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAAdlGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 175
Cdd:cd17319 51 YALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT--SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRA 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 176 LTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDtpethktishyekeyivsslknqlssqk 255
Cdd:cd17319 129 TGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ---------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 256 vvpwgsilkslpLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKwnf 335
Cdd:cd17319 181 ------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG--- 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 336 stisVRRIFSLVGMVGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFASSGFSINHLDIAP-SYAGILLGITNTFATIPG 414
Cdd:cd17319 246 ----ARRLVIIIGLLLAAVGLLLAYLTT-SPVVAVILLSLAGFGIGAASPVFWSLPADLLPgEAAATAGGLINSGGNLGG 320
|
410 420 430
....*....|....*....|....*....|....*
gi 568961401 415 MTGPIIAKSLTpdNTIREWQTVFCIAAAINVFGAI 449
Cdd:cd17319 321 FVAPLLIGYLV--DATGSYTAAFLFLAAVALLAAL 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-456 |
1.43e-38 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 143.47 E-value: 1.43e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 16 RYNLAILAFCGFFVLYALRVNLSVALVDMVDSnttltdnrtskecaehsapikvhhnhtgkkYKWDAETQGWILGSFFYG 95
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQAD------------------------------LGLSAAQLGLLASAFFLG 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 96 YIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAAdlGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKL 175
Cdd:COG2271 58 YALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 176 LTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFIlwmwivsdtpethktishyekeyivsslknqlssqk 255
Cdd:COG2271 136 LGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL------------------------------------ 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 256 vvpwgsilksLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLrvkwnf 335
Cdd:COG2271 180 ----------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL------ 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 336 stISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGM 415
Cdd:COG2271 244 --GRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 568961401 416 TGPIIAKSLTpdnTIREWQTVFCIAAAINVFGAIFFTLFAK 456
Cdd:COG2271 322 LGPLLVGYLL---DATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
78-451 |
2.69e-36 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 137.94 E-value: 2.69e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 78 YKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGvvTLVVLRALEGLGEGVTFP 157
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW--LLLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 158 AMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYY--MNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKti 235
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVVPDPPESAR-- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 236 shyekeyivSSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGC 315
Cdd:cd06174 182 ---------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 316 WLCMILCGQAADYLRvkwnfstisVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIA 395
Cdd:cd06174 253 ALGSLLLGLLSDRLI---------GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 568961401 396 PSYAGILLGITNTFATIPGMTGPIIAKSLTPDNTIreWQTVFCIAAAINVFGAIFF 451
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG--LTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
75-418 |
6.09e-30 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 119.45 E-value: 6.09e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 75 GKKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAAdlGVVTLVVLRALEGLGEGV 154
Cdd:pfam07690 24 AEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 155 TFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILwmWIVSDTPETHKT 234
Cdd:pfam07690 102 LFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL--LLLPRPPPESKR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 235 ISHYEKEYIVSslknqlssqkVVPWGSILKSLPLWAIVVAhFSYNWSFYTLLTLLPTYMkEILRFNVQENGFLSALPYFG 314
Cdd:pfam07690 180 PKPAEEARLSL----------IVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 315 CWLCMILCGQAADYLRVKwnfstisVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDI 394
Cdd:pfam07690 248 GAIGRLLLGRLSDRLGRR-------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 568961401 395 APSYAGILLGITNTFATIPGMTGP 418
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
86-455 |
1.60e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 107.28 E-value: 1.60e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 86 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADlgVVTLVVLRALEGLGEGVTFPAMHAMWSS 165
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS--YWQLLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 166 WAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTishyekeyivs 245
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 246 slKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQA 325
Cdd:cd17325 181 --RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 326 ADYLRvkwnfstisvRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGI 405
Cdd:cd17325 259 SDRIG----------RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 568961401 406 TNTFATIPGMTGPIIAKSLTpdnTIREWQTVFCIAAAINVFGAIFFTLFA 455
Cdd:cd17325 329 FNTAFSLGMVLGPLLGGFLY---DAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
76-454 |
2.17e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 104.58 E-value: 2.17e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 76 KKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVT 155
Cdd:COG2223 33 EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWL--LLLLGLLLGIGGGGS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 156 FPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPEthkti 235
Cdd:COG2223 111 FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPA----- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 236 shyekeyivssLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGC 315
Cdd:COG2223 186 -----------GAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 316 WLCMILCGQAADYlrvkwnfstISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIA 395
Cdd:COG2223 255 ALGRPLGGWLSDR---------IGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFP 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 568961401 396 PSYAGILLGITNTFATIPGMTGPIIAKSLTpdNTIREWQTVFCIAAAINVFGAIFFTLF 454
Cdd:COG2223 326 TKNAGAVYGLVGAAGGLGGFLGPLLFGALL--DATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
80-412 |
9.95e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 98.89 E-value: 9.95e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 80 WDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAM 159
Cdd:COG2814 42 ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL--LLAARFLQGLGAGALFPAA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 160 HAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIV-WFILWMWIVSDTPETHKTISHy 238
Cdd:COG2814 120 LALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLaLLLLLRLLPESRPAARARLRG- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 239 ekeyivsslknqlssqkvvPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLC 318
Cdd:COG2814 199 -------------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLG 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 319 MILCGQAADYLRvkwnfstisvRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSY 398
Cdd:COG2814 260 ALLAGRLADRFG----------RRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329
|
330
....*....|....
gi 568961401 399 AGILLGITNTFATI 412
Cdd:COG2814 330 RGRASGLYNSAFFL 343
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
87-423 |
4.79e-15 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 76.90 E-value: 4.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 87 WILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGvvTLVVLRALEGLGEGVTFPAMHAMWSSW 166
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFG--GLIALRFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 167 APPLERSKLLTISYAGAQLGTVislpLSGII---CYYM-------NWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTIS 236
Cdd:cd17327 123 YKREEQAKRIAFFYAAAGLGSI----FGGLLaygVFKIlgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLT 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 237 HYEKEYIVSSLKNQ---LSSQKVVP--WGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALP 311
Cdd:cd17327 199 EEEKELAVERLRANqtgKGDQKFKWkqIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 312 YFGCwLCMILCGQAADYLRVKWNFSTisvrrIFSLVGMVGPAVflvaagFIGCDYSLAVAFLTISTTLGGFASSGFSINH 391
Cdd:cd17327 279 ALGA-VSLLIAALLSDRFKKRGLFAI-----FACVLALVGSII------LLAAPNPPGAYFAAYILGGGSYAGFPILLSW 346
|
330 340 350
....*....|....*....|....*....|....*
gi 568961401 392 L-DIAPSYAG--ILLGITNTFATIPGMTGPIIAKS 423
Cdd:cd17327 347 IsSNCAGYTKraTVLAIMLIFYNVGNIVAPQIFRA 381
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
72-424 |
1.64e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 75.09 E-value: 1.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 72 NHTGKKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADlgVVTLVVLRALEGLG 151
Cdd:TIGR00895 41 PAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATN--VTQLLILRFLAGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 152 EGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWM--------W 223
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMrflpesidF 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 224 IVSDTPETHKTISHYEKEYIVSSLKNQLSSQKVVP--WGSILK----------SLPLWaivVAHFSYNWSFYTLLTLLPT 291
Cdd:TIGR00895 199 LVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQgtKRSVFKalfqgktariTVLLW---LLYFMLLVGVYFLTNWLPK 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 292 YMKEiLRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKwnfstisVRRIFSLVGmvgpAVFLVAAGFigcDYSLAVA 371
Cdd:TIGR00895 276 LMVE-LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR-------VTALLLLLG----AVFAVLVGS---TLFSPTL 340
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568961401 372 FLTISTTLGGFASSGFSINHLDIAPSYA--------GILLGITNTFATIpgmtGPIIAKSL 424
Cdd:TIGR00895 341 LLLLGAIAGFFVNGGQSGLYALMALFYPtairatgvGWAIGIGRLGAII----GPILAGYL 397
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
86-420 |
2.98e-14 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 73.95 E-value: 2.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 86 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFtpLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSS 165
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 166 WAPPLERSKLLTISYAGAQLGTVISLPLSGI-ICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTIS-----HYE 239
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPaeempNEE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 240 KEYIVSSLKNQLSSQKVVPWgSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCM 319
Cdd:TIGR00881 191 PDGDAEKKEEELTKKQIFLQ-YVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGT 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 320 ILCGQAADYLrvkwnfstisVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGF----SINHLDIA 395
Cdd:TIGR00881 270 LLAGWLSDKL----------FNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPqmliGVIASELA 339
|
330 340
....*....|....*....|....*.
gi 568961401 396 PSYA-GILLGITNTFATIPGMTGPII 420
Cdd:TIGR00881 340 PKKAaGTAAGFVGFFAYLGGILAGLP 365
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
86-454 |
1.35e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.97 E-value: 1.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 86 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLgvVTLVVLRALEGLGEGVTFPAMHAMWSS 165
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF--ALLLAGRALQGIGAAGLGPLALTLIGD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 166 WAPPLERSKLLTISYAGAQLGTVISlPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPEThktishyekeyivs 245
Cdd:cd17474 115 LFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEK-------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 246 slKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGcwlcmilcGQA 325
Cdd:cd17474 180 --AKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVL--------LAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 326 ADYLRVKWNFSTISVRRIFsLVGMVGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYA-GILLG 404
Cdd:cd17474 250 GSLFVGRLLKKRFGARRIL-VIGLLLYALSLLLLGFVP-SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEErGTASS 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 568961401 405 ITNTFATIPGMTGPIIAKSLTpdnTIREWQTVFCIAAAINVFGAIFFTLF 454
Cdd:cd17474 328 LYNFVRFLGQAVGPLLFGLLL---EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
140-405 |
1.07e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 59.89 E-value: 1.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 140 TLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYyMNWTYVFYLFGiVGIVWFI 219
Cdd:cd17473 90 ALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLI 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 220 LWMWIVSDTPETHKTISHYEKEyivsslknqlsSQKVVPWGSIlkslplWAIVVAHFSYNWSFYTLLTLLPTYMKEILRF 299
Cdd:cd17473 168 LVLLFLPEPARKSKSAASPGAA-----------TAAALPWKRV------LPIYFLAFLAMLLFYVIPIQLPFLLQERGGG 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 300 NVQENGFLSAlpyfgcwlcmilcgqaadylrvkwnfstisvrrIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTL 379
Cdd:cd17473 231 SAALIGLALA---------------------------------IASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGF 277
|
250 260
....*....|....*....|....*.
gi 568961401 380 GGFAssgfsinhldIAPSYAGILLGI 405
Cdd:cd17473 278 LLLA----------LASGLWVVLLGA 293
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
86-452 |
2.29e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 59.10 E-value: 2.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 86 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMWSS 165
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--LLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 166 WAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTishyekeyivs 245
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG----------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 246 slknqlSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQA 325
Cdd:cd17324 184 ------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 326 ADylrvkwnfsTISVRRIFSLVGMVgpAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGI 405
Cdd:cd17324 258 AD---------RGGRRALLIALLLL--AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSL 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 568961401 406 TNTFATIPGMTGPIIAkSLTPDNTirEWQTVFCIAAAINVFGAIFFT 452
Cdd:cd17324 327 YLAAYNLGGALGAALG-GLVLDHG--GWAGVGWVGAALLLLALLLAL 370
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
81-220 |
9.55e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 56.36 E-value: 9.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 81 DAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAadLGVVTLVVLRALEGLGEGVTFPAMH 160
Cdd:COG0477 47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARALQGIGAGGLMPGAL 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 161 AMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFIL 220
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVL 184
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
171-454 |
3.69e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.29 E-value: 3.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 171 ERSKLLTISYAGAQLGTVISLPLSGIICYYM------NWTYVFYLFGIVGIVWFILWMWIVSDTPETHKtishyEKEYIV 244
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE-----EKVSLK 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 245 SSLKnqlssqkvvpwgSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQ 324
Cdd:COG2211 219 ESLK------------ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPR 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 325 AADYlrvkwnfstISVRRIFsLVGMVGPAVFLVAAGFIGcdySLAVAFLTISTTLGGFASSGFSINHL----DIAP---- 396
Cdd:COG2211 287 LAKR---------FGKKKAF-IIGLLLAALGLLLLFFLG---PGNLWLLLVLAALAGIGLGAILVLPWamlaDVVDydew 353
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568961401 397 ----SYAGILLGITNTFATIPGMTGPII-----------AKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLF 454
Cdd:COG2211 354 ktgrRREGLYFGIFTFAIKLGQALAGALaglllalfgyvAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLF 426
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
101-451 |
4.38e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 51.92 E-value: 4.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 101 IPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISY 180
Cdd:cd17371 52 ILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 181 AGAQLG----TVISLPLSGIICYYMNWTYVFYLfgivGIVWFILWMWIVSDTPEThktishyeKEYIVSSLKNQLSSQKV 256
Cdd:cd17371 130 SGWAVGwllaTLLAALLFPLLPPEIAWRVLFLL----GALPALLVLFIRRFVKEP--------PQWQAARAARRHFADRP 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 257 VPWG---SILKSLPLWAIVVAHFSYnWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKW 333
Cdd:cd17371 198 SLRElfsPPLLRTTLLASLLATGAL-GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRN 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 334 NFstisvrRIFSLVGmvgpAVFLVAAGFIGCDYSLavaFLTISTTLGGFASSGFSINHLDIAPSYA----GILLGITNTF 409
Cdd:cd17371 277 NF------ALFALGS----AISILLYFFLPLSPTL---ILILGFPLGFFASGPFSGMGAYLTELFPtavrATAQGFCYNV 343
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 568961401 410 ATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFF 451
Cdd:cd17371 344 GRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALL 385
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
86-420 |
8.05e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 51.08 E-value: 8.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 86 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLglgilgtSVFTLFTPLAADL-----GVVTLVVLRALEGLGEGVTFPAMH 160
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVL-------AVGLLLMGAAALLmalvgSYPVLLVLLFLVGAGYGSVQPGGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 161 AMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFIL-WMWIvsdtpethktishye 239
Cdd:cd17475 107 RAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLfWLFY--------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 240 KEYIVSSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCM 319
Cdd:cd17475 172 REPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGR 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 320 ILCGQAADYLRVKwnfstisvRRIFSLVGMVGPAVfLVAAGFIGCDYSLAVAFLTISTTLGGFASSGF-SINHLDIA--- 395
Cdd:cd17475 252 IGLGRVSDRVFGG--------RRRPVLVITAAIAA-AALLVLSLLSPGTPLWLLVLLLILLGLFAIGWnGLYLTLVAesa 322
|
330 340
....*....|....*....|....*.
gi 568961401 396 -PSYAGILLGITNTFATIPGMTGPII 420
Cdd:cd17475 323 gPEQAGTALGLANTINFIGIAIGPPL 348
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
73-420 |
1.35e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 50.30 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 73 HTGKKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADlgVVTLVVLRALEGLGE 152
Cdd:cd17329 25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--PWLFAIALVLTGFGG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 153 GVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISlPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETH 232
Cdd:cd17329 103 GLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIG-PLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 233 ktishyekeyivsslKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPy 312
Cdd:cd17329 182 ---------------RAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALN- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 313 fgcwLCMILCGQaadYLRVKWnFSTISVRRIFsLVGMVGPAVFLVAAGFIGCDYSL--AVAFLTISTTLGGFASSGFsIN 390
Cdd:cd17329 246 ----ALLIVLLQ---FPVARL-VERFRLRKIL-MIGILLFAIGFAVLAFANTLAVLilAMIVLTLGEMLVFPAVQTL-VA 315
|
330 340 350
....*....|....*....|....*....|
gi 568961401 391 HLdIAPSYAGILLGITNTFATIPGMTGPII 420
Cdd:cd17329 316 AL-APPDKRGSYMGFYALAWGLGRAIGPLV 344
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
137-461 |
1.65e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 50.26 E-value: 1.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 137 GVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPpLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIV 216
Cdd:COG2807 105 SVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALL 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 217 WFILWMWIVSDTPETHKtishyekeyivsslknqlSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEi 296
Cdd:COG2807 184 ALLLWLPLLRRRPAAAA------------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD- 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 297 LRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTisvrrIFSLVGMVGPAVFLVAAGFigcdySLAVAFLTIS 376
Cdd:COG2807 245 AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLL-----LLGLLGLAGLLGLLLAPGS-----LPWLWAVLLG 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 377 TTLGGFASSGFS-INHLDIAPSYAGILLGITNTFATIPGMTGPIIA---KSLTPDntireWQTVFCIAAAINVFGAIFFT 452
Cdd:COG2807 315 LGQGGLFPLALTlIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVgalHDATGS-----WTAALLLLAALAVLMLVAGL 389
|
....*....
gi 568961401 453 LFAKGEVQS 461
Cdd:COG2807 390 LAGRPYVED 398
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
84-375 |
2.35e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 49.54 E-value: 2.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 84 TQGWILGSFF-YGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAM 162
Cdd:cd17328 34 SLAGLLQTVFiISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--LLLFRALVGIGEASYSPIAPTI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 163 WSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIIC-YYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHYEKE 241
Cdd:cd17328 112 IADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 242 YIVSSLKNqlssqkvvpWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSAlpYFGCWLCM-- 319
Cdd:cd17328 192 TATSFLAD---------LKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGL--IFGAITCIag 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 320 ----ILCGQAADYLRVKwnfsTISVRRIFSLVGMVGPAVFLVAAgFIGCDYSLAVAFLTI 375
Cdd:cd17328 261 vlgvLLGGILADRLRRK----TPRADPLVCAVGLLAAAPFLFLA-LVLALSNLLLAWVLL 315
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
125-220 |
2.66e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 49.50 E-value: 2.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 125 VFTLFTPLAA---DLGVvtLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYM 201
Cdd:cd17503 70 LFTLGSLLCGlapNLAS--LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNL 147
|
90
....*....|....*....
gi 568961401 202 NWTYVFYLFGIVGIVWFIL 220
Cdd:cd17503 148 SWRWIFYINLPIGILALLL 166
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
86-420 |
3.09e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.08 E-value: 3.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 86 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMwSS 165
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPL--LLLALFLLGLGLGLLDVAANPY-VA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 166 WAPPLERSKLLTISYAGAQLGTVISlPLSGIICYYMN----WTYVFYLFGIVGIVWFILWMWivSDTPETHKTISHyeke 241
Cdd:COG0738 123 ALGPETAASRLNLLHAFFSLGALLG-PLLGGLLILLGlslsWHLPYLILAVLLLLLALLFLR--SKLPEIEEEEEE---- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 242 yivsslknqlSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQEngflSALPYFGCWLCMIL 321
Cdd:COG0738 196 ----------AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEAT----AALGLSLFWGGMTI 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 322 CGQAADYLRVKWNFSTisVRRIFSLVGMVGPAVFLVAAGFIgcdysLAVAFLTIsttLGGFASSGFS-INHL--DIAPSY 398
Cdd:COG0738 262 GRFLGGFLLKRFGPVR--LLRLSALLAAVGLLLALLAPGPW-----LALIGLAL---VGLGLSLMFPtIFSLalDGLGKR 331
|
330 340
....*....|....*....|..
gi 568961401 399 AGILLGITNTFATIPGMTGPII 420
Cdd:COG0738 332 TAAAVSAVLIMGIVGGAIGPPL 353
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
76-225 |
3.77e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.11 E-value: 3.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 76 KKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAAdlGVVTLVVLRALEGLGEGVT 155
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 156 FPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIV 225
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
271-454 |
3.98e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.57 E-value: 3.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 271 IVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRvkwnfstisvRRIFSLVGMV 350
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG----------RRRVLLIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 351 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTpdnTI 430
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA---SL 147
|
170 180
....*....|....*....|....
gi 568961401 431 REWQTVFCIAAAINVFGAIFFTLF 454
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLLLLP 171
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
86-454 |
5.40e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 48.39 E-value: 5.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 86 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLF--TPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMW 163
Cdd:cd17345 41 GLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILigFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTM 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 164 SSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYM---NWTYVFYLFGIVGIVWFILWMWIVSDTPET------HKT 234
Cdd:cd17345 121 VHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFgdgWWRGAFIFPAIIAIIVAVIVLFLGKDTPESeglppiEEY 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 235 ISHYEKEYIVSSLKNQLSSQKVVpWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFG 314
Cdd:cd17345 201 KGDYPEEADGEEEEQELSAWEIF-VKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 315 CWLCMILCGQAADYLrvkwnfstISVRRifSLVGMVgpAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSG----FSIN 390
Cdd:cd17345 280 AIPGTLLAGWLSDKL--------FKGRR--APTGII--FMILVIVALIVYWLAPNVLVDLIALIALGFLIYGpvmlIGLQ 347
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568961401 391 HLDIAPSYA-GILLGITNTFATIPGMTGPIIAKSLTPDNTirEWQTVFcIAAAINVFGAIFFTLF 454
Cdd:cd17345 348 ALELVPKKAaGTAAGLTGLFGYLGGSVLATALIGIIVDHF--GWNGGF-IVLLASCILAIIFLAL 409
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
86-454 |
9.59e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.61 E-value: 9.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 86 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVT---LVVLRALEGLGEGVTFPAMHAM 162
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSlwlLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 163 WSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPEThktishyekey 242
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAA----------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 243 ivSSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYT-LLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMIL 321
Cdd:cd06173 186 --PGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGaLTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 322 CGQAADYLRvkwnfstisvRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGI 401
Cdd:cd06173 264 LGRLSKRRR----------RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGR 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 568961401 402 LLGITNTFATIPGMTGPIIAKSLTPDNTIRewqTVFCIAAAINVFGAIFFTLF 454
Cdd:cd06173 334 VFSVYNALNSGAMPLGALLAGLLADALGLS---AVFLLAGALLLLAALLLLLL 383
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
86-454 |
1.21e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 47.27 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 86 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMWSS 165
Cdd:cd17312 41 GIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWF--FAVLWGLNGLFQSMGWPPCVKLLGN 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 166 WAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPEThktishyekeyivs 245
Cdd:cd17312 119 WFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPPY-------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 246 slknqlssqkvvpwgsilkslpLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQA 325
Cdd:cd17312 185 ----------------------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 326 ADYLrvkWNFSTISVRRIFSLVGMVGPAVFLVAAGFIgcdYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYA-GILLG 404
Cdd:cd17312 243 SDKL---FGGRRAPIAVIYMLLMTLSLALFWFFPHNK---LLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAaGTATG 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 568961401 405 ITNTFATIPGMTGPIIAKSLTPDNTireWQTVFCIAAAINVFGAIFFTLF 454
Cdd:cd17312 317 FVGLFGYLGASLAGLPLGYIIDHYG---WSTVFYFLISAALLSVLLLLSL 363
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
86-229 |
2.21e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 46.49 E-value: 2.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 86 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGvvTLVVLRALEGLGEGVTFPAMHAMWSS 165
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFP--SLLVARLLTGVGLGGALPNLIALTSE 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568961401 166 WAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTP 229
Cdd:PRK11551 131 AVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESR 194
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
76-230 |
2.73e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.02 E-value: 2.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 76 KKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVT 155
Cdd:COG2271 209 EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGA 288
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568961401 156 FPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPE 230
Cdd:COG2271 289 FGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
81-220 |
3.34e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.04 E-value: 3.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 81 DAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADlgVVTLVVLRALEGLGEGVTFPAMH 160
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--VLQLALLRFLTGLGLGAAMPNAI 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 161 AMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFIL 220
Cdd:cd17365 110 TLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL 169
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
126-229 |
5.21e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 45.33 E-value: 5.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 126 FTLFTPLAA-DLGVVTLVVLRALEGLGEGVTFP-AMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNW 203
Cdd:cd17476 73 FAIWSLIAGfSPNFIFFIICRALQGLGPAFLLPnAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWW 152
|
90 100
....*....|....*....|....*..
gi 568961401 204 TYVFYLFGIVGIVWFIL-WMWIVSDTP 229
Cdd:cd17476 153 PWIFWFLAILAAIVAVAaIFWTSPSFI 179
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
81-420 |
8.39e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.51 E-value: 8.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 81 DAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLgvVTLVVLRALEGLGEGVTFPAMH 160
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP--ILLLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 161 AMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYM----NWTYVFYLFGIVGIVWFILWMWIvsdtpethktis 236
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRILFLIGALPALLALLLRRRT------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 237 hyekeyivsslknqlssqkvvpwgsilkslplWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCW 316
Cdd:cd17316 180 --------------------------------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 317 LCMILCGQAADYLRvkwnfstisvRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTIstTLGGFASSGFSINHLDIAP 396
Cdd:cd17316 228 VGALIAGLLSDRIG----------RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLF--ILSFFVGGVWGALYAYLAE 295
|
330 340
....*....|....*....|....*...
gi 568961401 397 SYA----GILLGITNTFATIPGMTGPII 420
Cdd:cd17316 296 LFPtevrATGVGLSYNLGRLGGGGAPPL 323
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
137-450 |
1.61e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 43.70 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 137 GVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIV 216
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 217 WFILwmwivsdtpethktishyekeyivsslknqlssqkvvpwgsilkSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEI 296
Cdd:cd17321 163 ALLL--------------------------------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGV 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 297 LRFNVQENGFLSaLPYFgcwLCMILCGQAADYLRVKWNFstisvrRIFSLVGMVGPAVFLVAAGFIGCDYS---LAVAFL 373
Cdd:cd17321 199 LGYSPLQAGLAL-LPLA---LAMLVAAPLAGRLADRFGP------RLVLVAGLLLTAVGLLLLALLGADSSvwlLLPGLV 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 374 TISTTLGGFASSGFSINHLDIAPSYAGILLGITNT--------------------FATIPGMTGPIIAKSLTPDNTIREW 433
Cdd:cd17321 269 LLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTarqlggalgvallgalltagLSANLGDSGVAALLSAAAAAFAAGF 348
|
330
....*....|....*..
gi 568961401 434 QTVFCIAAAINVFGAIF 450
Cdd:cd17321 349 HLAFLVAAALALLAALL 365
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
98-422 |
1.19e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.00 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 98 VTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVlrALEGLGEGVTFPAMHAMWSSWAPPlERSKLLT 177
Cdd:cd17478 46 LLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV--ALAGIGSAAFHPEGARLASQAAGG-RRGLAMS 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 178 ISYAGAQLGTVISlPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTIshyekeyivsslKNQLSSQKVV 257
Cdd:cd17478 123 IFSVGGNLGFALG-PLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKK------------AAAKSSARST 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 258 PWGSILKSLPLWAIVvahFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALpYFGCWLCMILCGQAADYlrvkwnfst 337
Cdd:cd17478 190 LKGVWRALLLLLIIV---FLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLF-LFAGAIGTLIGGPLSDR--------- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 338 ISVRRIFsLVGMVGPAVFLVAAGFIGCDYSLAVAFLTisttlGGFASSGFSINHL---DIAPSYAGILLGITNTFA-TIP 413
Cdd:cd17478 257 FGRRRVI-IASLLLAAPFLLLFLLTPGIWSYILLVLA-----GFLLFASFPVTVVlaqELLPGNVGLASGLMMGLSfGLG 330
|
....*....
gi 568961401 414 GMTGPIIAK 422
Cdd:cd17478 331 GIGAPVLGA 339
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
140-451 |
1.28e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 41.08 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 140 TLVVLRALEGLGeGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVIS----LPLSGIICY---YMNWTYVFYLFGI 212
Cdd:cd17341 90 GLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSqllaPLIAGAIVFdggFVGWRNAFFVPGI 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 213 VGIVWFILwMWIVSDTPETHKtishyekEYIVSSLKNQLSsqkvvpwgsILKSLPLWAIVVAHFSYNWSFYTLLTLLPTY 292
Cdd:cd17341 169 LLAIAAVL-VLLFGDDLPTGK-------ASALEFLKVQLA---------VLKNYRTWILSLLYGVTFGSFVGFSNVLPTY 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 293 MKEILRFNVQENGFLSALPYFGCWLCMILCGQAADylrvKWNFStisVRRIFSLVGMVGPAVFLVAAGFIgcDYSLAVAF 372
Cdd:cd17341 232 FKTRFGLPLVTAGILAALFPLAGALARPAGGWLSD----RFGGR---RRLWWLFIVMTIGAALLSLSLPT--SGTNLVLF 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 373 LTISTTLGGFASSGF-SINHL--DIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAI 449
Cdd:cd17341 303 LALFVALGLGAGAGNgSVFRMvpFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLV 382
|
..
gi 568961401 450 FF 451
Cdd:cd17341 383 WL 384
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
86-453 |
1.63e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.77 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 86 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAM----HA 161
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYL--FVVLMFLAGLGAGILDTGAntfvGA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 162 MWSSwapplERSKLLTISYAGAQLGTVISLPLSG-IICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHktishyek 240
Cdd:cd17333 112 LFEE-----SSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSA-------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 241 eyivsSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSAlpyfGCWLCMI 320
Cdd:cd17333 179 -----RNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLS----GFWVGIT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 321 LCgqaadylrvKWNFSTISVRrifslvgmVGPAVFLVAAGFIGCDYSLAVAFLT------ISTTLGGFASSG----FSIN 390
Cdd:cd17333 250 IG---------RLLGGPISRR--------IKPHTLLVLSGSGALLGLLILLLAPtlvvglVATALLGLFMAAlfptILSL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568961401 391 HLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPDNTIrewQTVFCIaaaINVFGAIFFTL 453
Cdd:cd17333 313 GISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGI---QTAMLL---ITILYAIIFVL 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
264-454 |
1.84e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.34 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 264 KSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEiLRFNVQENGFLSALPYFGCWLCMILCGQAADylrvkwnfsTISVRRI 343
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLAD---------RFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 344 FsLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKS 423
Cdd:COG2814 78 L-LLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
170 180 190
....*....|....*....|....*....|.
gi 568961401 424 LTpdnTIREWQTVFCIAAAINVFGAIFFTLF 454
Cdd:COG2814 157 LA---DLFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
79-224 |
3.37e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.52 E-value: 3.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 79 KWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPA 158
Cdd:cd06173 240 GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWL--LLAALFLLGLAGGLFNVP 317
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568961401 159 MHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWI 224
Cdd:cd06173 318 LNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
271-454 |
4.56e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.33 E-value: 4.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 271 IVVAHFSYNWSFYTLLTLLPTYMKEiLRFNVQENGFLSALPYFGCWLCMILCGQAADYLRvkwnfstisvRRIFSLVGMV 350
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFG----------RRPVLLLGLL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 351 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAkSLTPDNTI 430
Cdd:cd06174 70 LFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLG-GILASSLG 148
|
170 180
....*....|....*....|....
gi 568961401 431 REWQTVFCIAAAINVFGAIFFTLF 454
Cdd:cd06174 149 FGWRAVFLIAAALALLAAILLLLV 172
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
80-317 |
6.73e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.82 E-value: 6.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 80 WDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAadLGVVTLVVLRALEGLGEGVTFPAM 159
Cdd:cd06180 31 LSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALT--SGFAALLALRFLAGAASAFVFVFG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 160 HAMWSSWAPPLERSKLLTISYAGAQLGTVIS-LPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTIShy 238
Cdd:cd06180 109 SNLVLHHATAAGRGHLIGLLFAGVGLGIALSgLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEAS-- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 239 ekeyivsslknqlSSQKVVPWGsilksLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSAL---PYFGC 315
Cdd:cd06180 187 -------------AAESAPGLN-----RPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFglaAVPSC 248
|
..
gi 568961401 316 WL 317
Cdd:cd06180 249 FL 250
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
86-454 |
8.14e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.34 E-value: 8.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 86 GWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMWSS 165
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVAL--LLVLRLIHGIGWGAFTTAAATLVAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 166 WAPPLERSKLLTISYAGAQLGTVISLPLSGIIcyYMNWTY--VFYLFGIVGIVWFILwMWIVSDTPETHKTISHYEKeyi 243
Cdd:cd17489 112 IIPPSRRGEGIGYYGLATTLAMALGPALGLFL--YQHLGFavLFIVAAVLALLALLL-VFLVKDPPPVAAEEAEAGT--- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 244 vsSLKNQLSSQKVVPWGSILkslplwaiVVAHFSYNwsfyTLLTLLPTYMKEILRFNVqenGFLSALPYFGCWLCMILCG 323
Cdd:cd17489 186 --RAFRRLVEKKVLPPALIL--------FLASIAYG----AISTFLPLYAAERGISNA---GLFFTVYAIALLLSRPFSG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 324 QAADYLRVKWnfsTISVRRIFSLVGMV------GPAVFLVAAGFIGCDYSLAVAFLTIST------TLGGFASSGFSINh 391
Cdd:cd17489 249 KLSDRKGPKT---VIIPGLLLLALGLLllsfagSPWMLLLAAVLYGLGFGLLFPALQALAvdlvppHRRGAANGTFFIF- 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568961401 392 LDIAPSYAGILLGITNTFATIPGMtgpiiaksltpdntirewqtvFCIAAAINVFGAIFFTLF 454
Cdd:cd17489 325 FDLGIGLGGLLLGLVAELFGYRAM---------------------FLLAAVVVLLALVLYIFL 366
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
132-225 |
9.87e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 37.96 E-value: 9.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961401 132 LAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFG 211
Cdd:cd17489 274 LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAA 353
|
90
....*....|....
gi 568961401 212 IVGIVWFILWMWIV 225
Cdd:cd17489 354 VVVLLALVLYIFLL 367
|
|
| |
